Fungicidal combinations, mixtures and compositions and uses thereof

Abstract

To provide fungicides and combinations of fungicides that are safer, have better performance, are effective over long periods of time, require lower dosages, are easier to use, and cost less, and also provide a method for treating a plant or a locus of the plant against fungal infection.SOLUTION: The present invention provides fungicidal combination comprising: (i) a predetermined amount of a compound of Formula I and (ii) a predetermined amount of at least one fungicide (A) selected from the group consisting of fluindapyr, pydiflumetofen, mefentrifluconazole, and fenpicoxamid.SELECTED DRAWING: None

Description

[Technical field]

[0001] This application is the benefit of U.S. Provisional Patent Application No. 62 / 877,180, filed July 22, 2019. No. 6,399,433, filed on Dec. 13, 2003, the entire contents of which are incorporated herein by reference.

[0002] Throughout this application, various publications are referenced. The disclosures of these publications in their entireties are set forth at: No. 6,393,635, which is incorporated herein by reference in order to more fully describe the state of the art to which this invention pertains. do.

[0003] The present disclosure provides a method for treating a chronic inflammatory condition comprising administering to a patient a therapeutically effective amount of a compound of formula I, comprising administering to said patient a therapeutically effective amount of said compound of formula I, and ndapyr), pydiflumetofen, mefentrifluconazole ntrifluconazole, inpyrfluxam, isofetamide ), and at least one fungicide (A) selected from the group consisting of Qi inhibitors. The present disclosure also relates to compositions comprising the combinations described herein, and The present invention also relates to methods of using the combinations described herein. [Background technology]

[0004] Fungicides are natural compounds that act to protect plants from damage caused by fungi. or compounds of synthetic origin. Current agricultural practices rely heavily on the use of fungicides. In fact, some crops cannot be profitably grown without the use of fungicides. The use of pesticides allows growers to improve yields and crop quality, thereby increasing the value of their crops. In most situations, increased crop value will offset the cost of using fungicides. It is worth at least three times as much.

[0005] 5-Fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidine 2(1H)-ones include, but are not limited to, Zymoseptoria tritici, the pathogen of wheat leaf spot. tici (SEPTTR) and economically important crops, including fungi of the Ascomycota and Basidiomycota classes. It is a compound that provides control of various pathogens that adversely affect the

[0006] 5-Fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidine 2(1H)-ones have both prophylactic and therapeutic effects.

[0007] Use of N3-substituted-N1-sulfonyl-5-fluoropyrimidinone derivatives as fungicides This use is described in U.S. Patent No. 8,263,603, issued September 11, 2012. , the entire contents of which are incorporated herein by reference. The preparation of 1-tosyl-3,4-dihydropyrimidin-2(1H)-one is U.S. Patent No. 9,850,215 issued December 26, 2007 and U.S. Patent No. 9,850,215 issued December 12, 2017 No. 9,840,476, the entire contents of each of which are incorporated herein by reference. It is incorporated by reference in the notes.

[0008] U.S. Patent No. 8,263,603 also describes N3-substituted cyclic amines for the control or prevention of fungal infestation. -N1-sulfonyl-5-fluoropyrimidinone derivatives and phytologically acceptable carriers Microbicidal compositions containing the materials, as well as methods of use thereof, have been described.

[0009] 5-Fluoro-4-imino-3-(4-methylphenyl)-2-propanediol as a seed treatment to prevent or control plant diseases (Alkyl / Substituted Alkyl)-1-(Arylsulfonyl)-3,4-dihydropyrimidinyl The use of 1H-one is disclosed in U.S. Patent Application Publication No. 2018-011362, published on January 4, 2018. This is described in specification No. 2008 / 0000082.

[0010] 5-Fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidine Synergistic mixtures containing 2(1H)-ones and at least one fungicidal sterol biosynthesis inhibitor The compound is disclosed in U.S. Patent No. 9,526,245 issued on December 27, 2016 and This is described in U.S. Patent No. 10,045,533, issued August 14, 2018.

[0011] 5-Fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidine Synergistic combinations comprising a 2(1H)-one and at least one succinate dehydrogenase inhibitor The mixture is disclosed in U.S. Patent No. 9,532,570 issued on January 3, 2017 and U.S. Patent No. This was described in U.S. Patent No. 10,045,534, issued August 14, 2018.

[0012] Many fungicides are not useful in all situations, and repeated use of a single fungicide is not recommended. This often leads to the development of resistance to the relevant fungicides. They have better performance, are effective for longer periods, require smaller dosages, and are easier to use Research is being conducted to produce fungicides and fungicide combinations that are low in cost and There are.

[0013] Synergistic combinations, including mixtures, comprising a compound of formula I and at least one additional fungicide It is an object of the present disclosure to provide a composition, and to provide a mixture comprising the composition. It is a further object of the present disclosure to provide uses of these synergistic combinations. Summary of the Invention

[0014] The present invention relates to (i) an amount of a compound of formula I;

[0015] [ka] And (ii) a predetermined amount of fluindapyr, pydiflumetofen, ofen, mefentrifluconazole, inpirfluxam npyrfluxam, isofetamide, and Qi inhibitors. At least one fungicide (A) The present invention provides a disinfectant combination comprising:

[0016] The present invention also provides mixtures comprising the combinations described herein.

[0017] The present invention also provides compositions comprising the combinations described herein.

[0018] The present invention also relates to a method of treating a plant or the locus in which the plant is located against a fungal infection. (i) an amount of a compound of formula I;

[0019] [ka] And

[0020] (ii) a predetermined amount of fluindapyr, pydiflumetofen, ofen, mefentrifluconazole, inpirfluxam npyrfluxam, isofetamide, and Qi inhibitors. At least one fungicide (A) applying to the plant or the locus where the plant is located, thereby treating the plant against fungal infection. Also provided is a method comprising:

[0021] The present invention also relates to a method of treating a plant or the locus in which the plant is located against a fungal infection. an effective amount of any one of the combinations, mixtures or compositions described herein, Apply to the plant or the area where the plant is located, thereby Methods including treating a fungal infection are also provided.

[0022] The present invention also provides a method for controlling a plant disease caused by a plant pathogenic fungus, comprising the steps of: 2. Treating the plant or the locus in which the plant is located with an effective amount of a combination, mixture or composition described herein. and contacting the plant with any one of the above-mentioned compounds, thereby controlling the plant disease. Provide.

[0023] The present invention also provides a method for controlling fungal infestation in a plant, seed or seedling, comprising the steps of: Any one of the combinations, mixtures or compositions described may be applied to plants, seeds, seedlings, and / or or to the location where the plants are present, thereby treating the fungal infestation of the plants, seeds or seedlings. Also provided are methods for treating or preventing the disease.

[0024] The present invention also provides a method for controlling fungal infestation in a plant, seed or seedling, comprising the steps of: Any one of the combinations, mixtures or compositions described may be applied to plants, seeds, seedlings, and / or or where plants are present, thereby controlling fungal infestation of the plants, seeds or seedlings. Also provided is a method including controlling

[0025] The present invention also relates to treating plants, seeds or seedlings to produce plants that are resistant to fungal infestation. A method comprising administering to a subject a subject a composition comprising any one of the combinations, mixtures or compositions described herein. Plants, seeds adapted to produce said plants, seedlings adapted to produce said plants or to the location where said plant is present, thereby rendering the plant resistant to fungal infestation. Also provided is a method including producing the same.

[0026] The present invention also relates to a method for protecting a plant from fungal infestation, comprising administering to said plant a combination as described herein. applying any one of the mixtures or compositions to the plant, the locus where the plant is located, or is applied to a seed or seedling adapted to produce said plant, thereby producing the plant. Also provided are methods comprising protecting against fungal infestation.

[0027] The present invention also provides plants resistant to fungal infestation and a method adapted to produce said plants. The seed, seedling adapted to produce said plant, or the locus on which said plant is present, Treated with any one of the combinations, mixtures or compositions described herein There are.

[0028] The present invention also relates to a plant seed or a plant adapted to produce a plant resistant to fungal infestation. Also provided are seedlings, the plant seeds or seedlings being capable of growing in the presence of the combinations, mixtures or compositions described herein. The patients were treated with one of these drugs.

[0029] The present invention also provides a method for controlling fungal infestation in plants, comprising administering to a subject a combination as described herein. , mixture or composition may be applied to the location where the plant is present, to the plant, roots, leaves, seeds, Apply to areas where fungi are present and / or where you wish to prevent infestation, Thus, methods involving controlling fungal infestation in plants are also provided.

[0030] The present invention relates to a method for controlling fungal diseases of plants and / or soil, comprising the steps of: Any one of the combinations, mixtures or compositions may be applied to soil, plants, roots, leaves, seeds, fungal presence, where they are present and / or where you wish to prevent their infestation, thereby preventing plants and and / or controlling fungal diseases in the soil.

[0031] The present invention also provides a method for controlling a plant disease caused by a plant pathogenic fungus, comprising the steps of: The plant, plant propagation material, or locus in which the plant is present is treated with (i) a predetermined amount of a compound of formula I,

[0032] [ka] And (ii) a predetermined amount of fluindapyr, pydiflumetofen, ofen, mefentrifluconazole, inpirfluxam npyrfluxam, isofetamide, and Qi inhibitors. At least one fungicide (A) thereby controlling the plant disease.

[0033] The present invention also provides a method for controlling fungal infestation in a plant, seed or seedling, comprising the steps of: applying to the location of the seedling, and / or plant (i) a predetermined amount of a compound of formula I;

[0034] [ka] And (ii) a predetermined amount of fluindapyr, pydiflumetofen, ofen, mefentrifluconazole, inpirfluxam npyrfluxam, isofetamide, and Qi inhibitors. At least one fungicide (A) and thereby controlling fungal infestation of the plant, seed or seedling. Provide.

[0035] The present invention also provides a method for protecting a plant, seed or seedling from fungal infestation, comprising the steps of: , to the location of the seedlings and / or plants, (i) a predetermined amount of a compound of formula I,

[0036] [ka] And (ii) a predetermined amount of fluindapyr, pydiflumetofen, ofen, mefentrifluconazole, inpirfluxam npyrfluxam, isofetamide, and Qi inhibitors. At least one fungicide (A) and thereby protecting the plant, seed or seedling from fungal infection. Provide.

[0037] The present invention also relates to a method for treating a plant or the locus where a plant is present against a fungal infection, comprising the steps of: There is also provided the use of any one of the combinations, mixtures or compositions described herein.

[0038] The present invention also provides a method for treating a plant or the locus where the plant is located against a fungal infection. The present invention also provides any one of the combinations, mixtures or compositions described herein, [Brief description of the drawings]

[0039] [Figure 1] Comparison of area under the disease progress curve (AUDPC) from infection of the first leaves of wheat seedlings cultivar Alixan with Zymoseptoria tritici strain Mg Tri-R6 at 21 and 28 dpi intensities after treatment with untreated controls and with 5 or 10 g ai / ha of the compound of formula I, 0.39 g ai / ha of mefentrifluconazole, a mixture of 0.39 g ai / ha of mefentrifluconazole and 5 g ai / ha of the compound of formula I, or a mixture of 0.39 g ai / ha of mefentrifluconazole and 10 g ai / ha of the compound of formula I. Values ​​followed by the same letter are not significantly different (p<0.05) by the Newman-Keuls test. [Diagram 2] Comparison of area under the disease progress curve (AUDPC) from infection of the first leaves of wheat seedling cultivar Alixan with Zymoseptoria tritici strain Mg Tri-R6 at 21 and 28 dpi intensities after treatment with untreated controls and with 5 or 10 g ai / ha of the compound of formula I, 0.39 g ai / ha of fenpicoxamid, a mixture of 0.39 g ai / ha of fenpicoxamid and 5 g ai / ha of the compound of formula I, or a mixture of 0.39 g ai / ha of fenpicoxamid and 10 g ai / ha of the compound of formula I. Values ​​followed by the same letter are not significantly different (p<0.05) by the Newman-Keuls test. [Diagram 3]Comparison of area under the disease progress curve (AUDPC) from infection of wheat seedling cultivar Alixan with Zymoseptoria tritici strain Mg Tri-R6 at 21 and 28 dpi intensity on the first leaves after treatment with untreated control and with 5 or 10 g ai / ha of the compound of formula I, 0.39 g ai / ha of fluindapyr, a mixture of 0.39 g ai / ha of fluindapyr and 5 g ai / ha of the compound of formula I, or a mixture of 0.39 g ai / ha of fluindapyr and 10 g ai / ha of the compound of formula I. Values ​​followed by the same letter are not significantly different (p<0.05) by Newman-Keuls test. [Figure 4] Figure 1. Reaction rates of Zymoseptoria tritici strain Mg at 21 and 28 dpi intensities on the first leaves of wheat seedling cultivar Alixan after treatment with untreated controls and with 5 or 10 g ai / ha of the compound of formula I, 0.00032 g ai / ha, 0.0016 g ai / ha and 0.006 g ai / ha of pydiflumetofen, a mixture of 0.00032 g ai / ha of pydiflumetofen and 5 g ai / ha of the compound of formula I, a mixture of 0.0016 g ai / ha of pydiflumetofen and 5 g ai / ha of the compound of formula I, or a mixture of 0.008 g ai / ha of pydiflumetofen and 5 g ai / ha of the compound of formula I. Comparison of area under the disease progression curve (AUDPC) from infection with Tri-R6. Values ​​followed by the same letter are not significantly different (p<0.05) according to the Newman-Keuls test. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0040] definition Unless otherwise defined, all technical and scientific terms used herein are It has the meaning commonly understood by those skilled in the art to which this subject matter pertains.

[0041] As used herein, the term "compound of Formula I" includes, but is not limited to, all solid forms thereof. The compounds of formula I may be in the form of, but not limited to, amorphous, crystalline, solvated, or hydrated. The crystal form is described in PCT International Application Publication No. 2019 / 038583, published on February 28, 2019. The term " "Compounds of formula I" also include salts and optical isomers thereof.

[0042] As used herein, the term "combination" refers to simultaneous or contemporaneous "emporaneous" refers to an assemblage of pesticides applied by either do.

[0043] As used herein, the term "simultaneous" when used in connection with the application of a pesticide means that the pesticide is applied in a mixture. In a simultaneous application, the combination is a mixture. or in separate containers each containing the pesticides that are to be combined prior to application. It is possible.

[0044] As used herein, the term "contemporaneous" when used in relation to the application of a pesticide refers to the application of an individual pesticide. The effect of either pesticide alone, either simultaneously or at the same dose, from another pesticide or premixture An additive, greater than additive, or synergistic effect is achieved compared to This means that they are applied separately and close enough in time that they are mutually exclusive.

[0045] As used herein, the term "mixture" refers to, but is not limited to, a combination of any physical forms. , for example, blends, solutions, suspensions, dispersions, emulsions, alloys, and the like.

[0046] As used herein, the term "tank mix" refers to the mixture of the present invention with the fertilizer at the time of or prior to spray application. adding one or more components of the disclosed combination, mixture or composition to a spray tank; It means to mix.

[0047] As used herein, the term "composition" refers to at least one agriculturally acceptable carrier. This includes combinations or mixtures of the present invention.

[0048] As used herein, the term "effective" refers to the amount of an active ingredient, combination, mixture or composition. When used in conjunction with other substances, it is applied to plants, plant propagation material, soil or the area where plants are present. An activity that achieves an agriculturally beneficial level of control of fungi, pathogens and / or diseases when "Quantity of active ingredient, combination, mixture or composition."

[0049] As used herein, the term "fungicidal effective amount" refers to the amount of fungi or fungi that is commercially recommended for use in controlling fungi. The commercially recommended amount of each active ingredient is often In most cases, the dosage is specified as the dosage for commercially available products and is written on the label attached to the commercially available product. Commercially recommended application rates for commercial formulations vary depending on the plant species and the area to be controlled. The number of times the concentration of the fungus is increased may vary depending on factors such as the fungus being treated.

[0050] As used herein, the term "effective" refers to treating a plant or the locus in which the plant resides against fungal infection. When used in connection with the method of treating, the method significantly inhibits normal growth and development of plants. Provides an agriculturally beneficial level of treatment without interfering.

[0051] As used herein, the term "treating a plant or the locus in which a plant is present against a fungal infection" refers to Examples of such methods include, but are not limited to, treating plants or the area in which they reside against fungal infection. To protect and / or control fungal infections of plants or the areas in which they occur. The following are some of the reasons:

[0052] As used herein, the term "protecting a plant or the locus in which the plant resides against fungal infection" means Examples of such measures include, but are not limited to, protecting the plant or the area in which it resides from fungal infestation. to protect the plant or the area in which it is located from fungal diseases; and / or or to prevent fungal infection of the plant or the locus in which the plant resides.

[0053] As used herein, the term "controlling fungal infection in a plant or in the locus where the plant is located" means , including but not limited to, controlling fungal diseases that infect plants or the area in which they are present. to control plant or soil diseases caused by plant pathogenic fungi; To control fungal infestations on objects or vegetative sites; to reduce fungal infections in areas where the fungi are present and / or to prevent the development of diseases caused by plant pathogenic fungi; Treating plant or soil diseases.

[0054] As used herein, the term "a compound useful in protecting plants or the locus in which they occur against fungal infestation" refers to a compound that is useful in protecting plants or the locus in which they occur against fungal infestation. "More effective" includes, but is not limited to, protection against fungal infestation after application. and increasing the duration of protection against fungal infestation.

[0055] As used herein, the term "more effective in controlling fungal diseases" includes, but is not limited to, However, the effectiveness of fungal disease control is increased and the number of steps required to achieve a given level of fungal control is also increased. One advantage of this method is that it reduces the time required.

[0056] As used herein, the term "protective application" refers to the treatment of fungal infections of plants or the locus in which the plants are present. and the term "bactericidal combination, mixture or composition" refers to the application of one or more bactericides to prevent infection with the sensitizing agent. It is applied before infection occurs, before any symptoms are present, or when the disease is at a low level. The severity of the disease is based on spore concentration and certain environmental conditions that are associated with disease development. It can be evaluated based on the above.

[0057] As used herein, the term "therapeutic application" refers to the treatment of fungal infections in plants or in the locus where the plants reside. and the fungicide combination, mixture or composition refers to the application of one or more fungicides to control the It is applied after infection or after symptoms are present.

[0058] As used herein, the term "agriculturally acceptable carrier" refers to a composition for agricultural or horticultural use. By carrier is meant a carrier known and accepted in the art for the formulation of the product.

[0059] As used herein, the term "adjuvant" refers to an ingredient that is not an active ingredient itself, but is used to Adjuvants are any substances that enhance or are intended to enhance the effectiveness of fungicides. Adjuvants are broadly defined as spreading agents, penetrating agents, compatibilizers, and drift retardants. It can be understood to include.

[0060] As used herein, the term "agriculturally acceptable inert additive" refers to an ingredient that is not itself an active ingredient. However, any substances added to the composition, such as adhesives, surfactants, synergists, buffers, etc. , acidifier, antioxidant, antifoaming agent and thickener.

[0061] As used herein, the term "plant" refers to the entire plant, plant organs (e.g., leaves, stems, twigs, roots, trunks, , branches, shoots, fruits, etc.), plant cells, and plant reproductive material.

[0062] As used herein, the term "plant" refers to field crops (such as soybean, maize, wheat, rice, etc.), veggies, and the like. References to crops including vegetables (potatoes, cabbage, etc.), and fruits (peaches, etc.) include.

[0063] As used herein, the term "propagation material" refers to any material, such as seeds and spores. All reproductive parts of plants, including seedlings, as well as bulbs, corms, tubers, rhizomes, roots, stems, shoots, basals It should be understood that this refers to growth structures such as shoots, stolon, and buds.

[0064] As used herein, the term "location" refers to the area where a fungal infection may already be present, as well as the area where a fungal infection may already be present. This includes areas where contamination has not yet been demonstrated and areas under cultivation. Examples of suitable growing media include, but are not limited to, soil and other plant growth media.

[0065] As used herein, the term "ha" refers to hectare.

[0066] As used herein, the term "excipient" refers to a significant additive such as a surfactant, solvent, or adjuvant. The term "pesticide" refers to any chemical substance that does not have significant insecticidal activity. The composition may be added to any combination, mixture or composition comprising:

[0067] As used herein, the term "stabilizing surfactant" refers to a liquid combination, mixture, or mixture that includes a compound of formula I. The physical and / or chemical stability of the compound of formula I when added to a product or composition. In some embodiments, a stabilizing surfactant is defined as any surfactant that improves The agent is effective in inhibiting crystal growth.

[0068] The terms "a" or "an" are not specifically defined herein. Thus, the terms "a," "an," "the," and "the )" or "at least one" may be used interchangeably in this application.

[0069] Throughout this application, descriptions of various embodiments use the term "comprising." Although the present disclosure uses the term "constituting a part" in its entirety, in some particular circumstances, an embodiment may "consist essentially of" "consisting of" or "essentially of" It will be understood by those skilled in the art that this may be achieved.

[0070] The term "about" is used specifically herein to include ±10% of the value indicated in the range. In addition, all ranges herein directed to the same component or property are inclusive and are independently combinable and include all intermediate points and ranges.

[0071] If a parameter range is provided, all integers within that range and their decimal points are returned. The decimal places are also used as if integers and their decimal places were expressly set forth herein. For example, the present invention provides "5 g / ha to 120 g / ha ” is 5.0g / ha, 5.1g / ha, 5.2g / ha, 5.3g / ha, 5.4g / ha ha etc. up to a maximum of 120g / ha.

[0072] All publications, patents, and patent applications mentioned herein are hereby incorporated by reference as if each was individually incorporated by reference. Has each publication, patent, or patent application been specifically and individually incorporated by reference? No. 6,393,945, which are incorporated by reference in their entireties to the same extent as if fully set forth herein.

[0073] The following examples illustrate the practice of the present subject matter in some embodiments, but are not intended to limit the scope of the present subject matter. and should not be construed as limiting within the spirit and scope of the appended claims. The specification and examples are considered part of the present invention and other embodiments will be apparent to those skilled in the art. The present specification, including the examples, is not intended to limit the scope and spirit of the present invention. are intended to be illustrative only.

[0074] Aspects and embodiments of the present invention are now described.

[0075] Sterilizing combinations, mixtures, and compositions The present invention relates to a method for producing a compound comprising: (i) an amount of a compound of formula I;

[0076] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from The present invention provides a disinfectant combination comprising:

[0077] The present invention relates to a method for producing a compound comprising: (i) an amount of a compound of formula I;

[0078] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from The present invention provides a synergistic bactericidal combination comprising:

[0079] The present invention relates to a method for producing a compound comprising: (i) an amount of a compound of formula I;

[0080] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from A disinfectant combination comprising: The combination is preferably used in treating plants or the locus where the plants are present against fungal infections, is more effective than the equivalent amount applied alone, A disinfectant combination is provided.

[0081] The present invention relates to a method for producing a compound comprising: (i) an amount of a compound of formula I;

[0082] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from A disinfectant combination comprising: The amount of the compound of formula I and the amount of the fungicide (A), when applied together, In treating plants or plant sites against fungal infections, equal amounts of each fungicide should be used alone. more effective when applied, A disinfectant combination is provided.

[0083] The present invention relates to a method for producing a compound comprising: (i) an amount of a compound of formula I;

[0084] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from A disinfectant combination comprising: The amount of the compound of formula I used is preferably 0.01 to 0.15 times the bactericidal activity of the compound of formula I when used alone. Less than effective and / or The amount of fungicide (A) used is the same as the bactericidal effect of fungicide (A) when it is used alone. Less effective than A disinfectant combination is provided.

[0085] In some embodiments, the combination is synergistic.

[0086] In some embodiments, the combination is a mixture. In some embodiments, the mixture is a tank. A mix. In some embodiments, the mixture is synergistic.

[0087] The present invention relates to a method for producing a compound comprising: (i) an amount of a compound of formula I;

[0088] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from The present invention provides a disinfectant combination comprising:

[0089] The present invention relates to a method for producing a compound comprising: (i) an amount of a compound of formula I;

[0090] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from The present invention provides a synergistic bactericidal combination comprising:

[0091] The present invention relates to a method for producing a compound comprising: (i) an amount of a compound of formula I;

[0092] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from A disinfectant combination comprising: The mixture is intended to treat plants or plant sites against fungal infections, and each fungicide more effective than the same amount applied alone, A fungicide mixture is provided.

[0093] The present invention relates to a method for producing a compound comprising: (i) an amount of a compound of formula I;

[0094] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from A disinfectant combination comprising: A given amount of a compound of formula I and a given amount of a fungicide (A), when applied together, reduces the fungal infection In treating plants or plant sites against each other, the same amount of each fungicide was applied alone. It is more effective if A fungicide mixture is provided.

[0095] The present invention relates to a method for producing a compound comprising: (i) an amount of a compound of formula I;

[0096] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from A disinfectant combination comprising: The amount of the compound of formula I used is preferably 0.01 to 0.15 times the bactericidal activity of the compound of formula I when used alone. Less than effective and / or The amount of fungicide (A) used is the same as the bactericidal effect of fungicide (A) when it is used alone. Less effective than A fungicide mixture is provided.

[0097] The present invention also relates to a sterilizing agent comprising any one of the combinations or mixtures disclosed herein. Pharmaceutical compositions are also provided.

[0098] As used herein, the compound of formula I is 5-fluoro-4-imino-3-methyl-1-tosyl -3,4-dihydropyrimidin-2(1H)-one, which has the structure:

[0099] [ka]

[0100] As used herein, fluindapyr refers to 3-(difluoromethyl)-N-( 7-Fluoro-2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl )-1-methyl-1H-pyrazole-4-carboxamide, which has the following structure: Has:

[0101] [ka]

[0102] Fluindapyr is a succinate dehydrogenase inhibitor (SDHI). do.

[0103] As used herein, pydiflumetofen refers to 3-(difluoromethyl) -N-Methoxy-1-methyl-N-[(2S)-1-(2,4,6-trichlorophenyl )propan-2-yl]-1H-pyrazole-4-carboxamide, It has the structure:

[0104] [ka]

[0105] Pydiflumetofen is a succinate dehydrogenase inhibitor (SDH I) A fungicide that is effective against soybeans, grains, vegetables, corn, peanuts, and currants. s), potatoes, top fruit, grapes, melons, and yams, Powdery mildew (Uncinula necator), Septoria leaf spot ), Cercospora leaf spot, Alternaria leaf spot, Scab Venturia inaequalis, and grey mold It is used to protect against Botrytis cinerea.

[0106] As used herein, mefentrifluconazole refers to the 2-[4- (4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1,2,4 -triazol-1-yl)propan-2-ol, which has the following structure: :

[0107] [ka]

[0108] Mefentrifluconazole is a sterol biosynthesis inhibitor ( Demethylation inhibitor) fungicide, effective against Septoria tritici for cereals Used against

[0109] As used herein, fenpicoxamid refers to the (3S,6S,7R,8R) -8-Benzyl-3-{3-[(isobutyryloxy)methoxy]-4-methoxypyridin {6-methyl-4,9-dioxo-1,5-dioxonane-7-yl}-2-carboxamide is the common name for -yl-isobutyrate and has the following structure:

[0110] [ka]

[0111] Fenpicoxamid is a Qi inhibitor fungicide that inhibits wheat pathogens (Zy Used against moseptoria tritici.

[0112] As used herein, inpyrfluxam refers to 3-(difluoromethyl)- N-[(R)-2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl ]-1-methyl-1H-pyrazole-4-carboxamide, which has the following structure: Has:

[0113] [ka]

[0114] Inpyrfluxam is a succinate dehydrogenase inhibitor (SDHI) ).

[0115] As used herein, isofetamide is N-[1,1-dimethyl-2-(4 -isopropoxy-o-tolyl)-2-oxoethyl]-3-methylthiophene-2-carboxylate It is the generic name for ruboxamide and has the following structure:

[0116] [ka]

[0117] Isofetamide is a succinate dehydrogenase inhibitor (SDHI). do.

[0118] In some embodiments, the compound of formula I may be, but is not limited to, amorphous, crystalline, solvated, or crystalline. The crystalline forms of the compounds of formula I are referred to by reference herein as crystalline forms, including solvates or hydrates. PCT International Publication No. 2019-02-28, published on February 28, 2019, the entire contents of which are incorporated by reference. This is described in Patent Publication No. 019 / 038583.

[0119] In some embodiments, the fungicide (A) is fluindapyr.

[0120] In some embodiments, the fungicide (A) is pydiflumetofen.

[0121] In some embodiments, the fungicide (A) is mefentrifluconazole.

[0122] In some embodiments, the fungicide (A) is isofetamide.

[0123] In some embodiments, the fungicide (A) is impirfluxam.

[0124] In some embodiments, the fungicide (A) is a Qi inhibitor.

[0125] In some embodiments, the Qi inhibitor is cyazoimidazole. Cyazoimidazole is cyazofamid.

[0126] In some embodiments, the Qi inhibitor is a sulfamoyltriazole. In one embodiment, the sulfamoyltriazole is amisulfurbrom.

[0127] In some embodiments, the Qi inhibitor is a picolinamide. The phosphorus amide is fenpicoxamid.

[0128] In some embodiments, the compound of formula I and the fungicide (A) in the combination, mixture or composition In some embodiments, the weight ratio of the combination, mixture, Or the weight ratio of the compound of formula I to the fungicide (A) in the composition is 200:1 to 1:100. In some embodiments, the compound of formula I and a fungicide ( A) is 50:1 to 1:50 by weight. Or the weight ratio of the compound of formula I to the fungicide (A) in the composition is 10:1 to 1:10. In some embodiments, the compound of formula I and the fungicide (A) in the combination, mixture or composition In some embodiments, the weight ratio of the combination, mixture or composition is 5:1 to 1:5. The weight ratio of the compound of formula I to the fungicide (A) in the composition is 2:1 to 1:2. In the form, the weight ratio of the compound of formula I to the fungicide (A) in the combination, mixture or composition is In some embodiments, the combination, mixture or composition has the formula The weight ratio of the compound of formula I to the fungicide (A) is 10:1 to 30:1. The weight ratio of the compound of formula I to the fungicide (A) in the combination, mixture or composition is 25 In some embodiments, the combination, mixture or composition has the formula The weight ratio of the compound of formula I to the fungicide (A) is 25:1. The weight ratio of the compound of formula I to the fungicide (A) in the product, mixture or composition is 12.5:1. In some embodiments, the compound of formula I and a fungicide ( The weight ratio of A) is 1:1.

[0129] In some embodiments, the combination, mixture, or composition is synergistic. In the form, the combination, mixture, or composition may be used to treat a plant or plant that is present against fungal infection. In some embodiments, the combination, mixture, or combination In some embodiments, the combination, mixture, or composition has a synergistic therapeutic effect. The substances have a synergistic protective effect.

[0130] In some embodiments of the combinations, mixtures, or compositions described herein, the bactericidal effect Synergistic with SEPTTR in protective and / or therapeutic applications The weight ratio of the compound of formula I to the fungicide (A) is in the range of about 200:1 to 1:200. do.

[0131] In some embodiments of the combinations, mixtures, or compositions described herein, the bactericidal effect Synergistic with SEPTTR in protective and / or therapeutic applications The weight ratio of the compound of formula I to the fungicide (A) is in the range of about 100:1 to 1:100. do.

[0132] In some embodiments of the combinations, mixtures, or compositions described herein, the bactericidal effect Synergistic with SEPTTR in protective and / or therapeutic applications The weight ratio of the compound of formula I to the fungicide (A) is within the range of about 50:1 to 1:50.

[0133] In some embodiments of the combinations, mixtures, or compositions described herein, the bactericidal effect Synergistic with SEPTTR in protective and / or therapeutic applications The weight ratio of the compound of formula I to the fungicide (A) is within the range of about 10:1 to 1:10.

[0134] In some embodiments of the combinations, mixtures, or compositions described herein, the bactericidal effect Synergistic with SEPTTR in protective and / or therapeutic applications The weight ratio of the compound of formula I to the fungicide (A) is within the range of about 5:1 to 1:1.

[0135] In some embodiments, the SEPTTR is a wheat pathogen (Zymoseptoria tritici).

[0136] In some embodiments, the compounds of formula I, whose germicidal effects are synergistic in protective applications, The weight ratio of the disinfectant (A) to the disinfectant (B) is in the range of about 400:1 to 1:400. In this embodiment, the fungicidal effects of the compound of formula I and the fungicide (A) are synergistic in protective applications. In some embodiments, the weight ratio of the antibacterial agent to the antiseptic agent is in the range of about 200:1 to 1:200. The weight ratio of the compound of formula I to the fungicide (A), in which the effect is synergistic in protective applications, is In some embodiments, the germicidal effect is in the range of about 100:1 to 1:100. The weight ratio of the compound of formula I to the fungicide (A) which is synergistic in application is about 50:1 to 1. In some embodiments, the germicidal effect is in the range of 0.5 to 50. The weight ratio of the compound of formula I which is synergistic with (A) is within the range of about 10:1 to 1:10. In some embodiments, the fungicidal effects of the compounds of formula I and The weight ratio of the fungicide (A) is in the range of about 5:1 to 1:5. The weight ratio of the compound of formula I to the fungicide (A) in which the fungicidal effect is synergistic in protective applications. In some embodiments, the germicidal effect is in the range of about 2:1 to 1:2. The weight ratio of the compound of formula I to the fungicide (A) which is synergistic in the present invention is about 25:1. In some embodiments, the fungicidal effects of the compounds of formula I and The weight ratio of the bactericide (A) is about 12.5:1. In some embodiments, the bactericidal effect is maintained. The weight ratio of the compound of formula I to the fungicide (A) which is synergistic in protective applications is about 1: The answer is 1.

[0137] In some embodiments, the bactericidal effects of the compounds of formula I are synergistic in therapeutic applications. The weight ratio of the disinfectant (A) to the disinfectant (B) is in the range of about 400:1 to 1:400. In this embodiment, the fungicidal effects of the compound of formula I and the fungicide (A) are synergistic in therapeutic applications. In some embodiments, the weight ratio of the antibacterial agent to the antiseptic agent is in the range of about 200:1 to 1:200. The weight ratio of the compound of formula I to the fungicide (A) in which the results are synergistic in therapeutic applications is: In some embodiments, the bactericidal effect is in the range of about 100:1 to 1:100. The weight ratio of the compound of formula I to the fungicide (A) which is synergistic in application is about 50:1 to 1. In some embodiments, the bactericidal effects are synergistic in therapeutic applications. The weight ratio of the compound of formula I to the fungicide (A) is in the range of about 10:1 to 1:10. In some embodiments, the compounds of formula I, whose bactericidal effects are synergistic in therapeutic applications, are The weight ratio of the substance to the fungicide (A) is within the range of about 5:1 to 1:5. The compound of formula I and the fungicide (A) are synergistic in their fungicidal effects in therapeutic applications. The ratio is in the range of about 2:1 to 1:2. In some embodiments, the bactericidal effect is greater than the therapeutic effect. The weight ratio of the compound of formula I to the fungicide (A) which is synergistic in application is about 25:1. In some embodiments, the compounds of formula I, whose bactericidal effects are synergistic in therapeutic applications, are The weight ratio of the product to the germicide (A) is about 12.5:1. In some embodiments, the germicidal effect The weight ratio of the compound of formula I to the fungicide (A) which is synergistic in therapeutic applications is about It's 1:1.

[0138] In some embodiments, the combination, mixture, or composition comprises at least one insecticide. Further includes:

[0139] In some embodiments, the combination, mixture, or composition comprises at least one stabilizing domain. In some embodiments, the combination, mixture, or composition comprises at least In some embodiments, the combination, mixture, or composition comprises two stabilizing surfactants. In some embodiments, the combination, mixture, or composition includes two stabilizing surfactants. The composition includes a stabilizing system.

[0140] In some embodiments, one of the stabilizing surfactants is a non-ionic stabilizing surfactant. In some embodiments, the non-ionic stabilizing surfactant is a polymeric, alkoxylated diene esters of diethylethanolamine, polyalkylene oxide alcohol ethers, and alcohols.

[0141] In some embodiments, the polymer is a block polymer of a random polymer. In some embodiments, the polymer is a triblock polymer. The block polymer is an ABA block polymer. In some embodiments, the polymer is , and has a low HLB (hydrophilic-lipophilic balance) value, preferably an HLB value of 5. In an embodiment, the polymer is Atlox™ 4912 (manufactured and sold by Croda). (which is currently being sold).

[0142] In some embodiments, the ester of an alkoxylated amine is Atlox™ 491 5 Alkoxylated diethylethanolamine, diethylethanolamine monotrimer or Altox® 4915 (manufactured and sold by Croda) It is.

[0143] In some embodiments, the alkoxylated fatty alcohol is Genapol X080 ( (manufactured and sold by Clariant), Genapol X050 (Cl (manufactured and sold by Ariant Corporation), tridecyl alcohol polyglycol Ether, Rhodasurf LA30 (manufactured and sold by Solvay) Aerosol OT-SE or Aerosol OT-100 (Solvay Rhodacal 70 / B (manufactured and sold by Solvay) Arlatone TV (manufactured and sold by Croda) Alkamuls A (manufactured and sold by Solvay) ), or Alkamuls BR (manufactured and sold by Solvay) be.

[0144] In some embodiments, the alcohol has a short carbon chain of C1 to C6. In the case of alcohols, the alcohols have long carbon chains of C7 to C20.

[0145] In some embodiments, the non-ionic stabilizing surfactant is a polyalkylene oxide polya It is a non-ionic derivative of aryl ether.

[0146] In some embodiments, one of the stabilizing surfactants is an ionic surfactant. In an embodiment, the ionic stabilizing surfactant is an anionic stabilizing surfactant. Stabilizing surfactants are compounds with anionic groups such as phosphonates and sulfonates. An example of an ionic surfactant that can be used is Aerosol® OT-SE Dioctyl sodium sulfosuccinate, manufactured and sold by Solvay as It is.

[0147] In some embodiments, the anionic stabilizing surfactant is a polyalkylene oxide polyaryl. It is an anionic derivative of diphenyl ether.

[0148] In some embodiments, the combination, mixture, or composition comprises at least one nonionic In some embodiments, the surfactant comprises at least one ionic stabilizing surfactant and at least one anionic stabilizing surfactant. In an embodiment, the stabilizing system comprises at least one non-ionic stabilizing surfactant and at least Also included is one anionic stabilizing surfactant.

[0149] In some embodiments, a non-ionic stabilizing surfactant and an anionic stabilizing surfactant are used. In some embodiments, the combination, mixture, or composition comprising the non-ionic surfactant is a SC composition. A combination, mixture, or mixture comprising anionic stabilizing surfactants and anionic stabilizing surfactants. The composition is an SE composition.

[0150] In some embodiments, one of the stabilizing surfactants is a polyalkylene oxide polyaryl In some embodiments, the polyalkylene oxide polyaryl ether derivatives are The ether derivatives are non-ionic derivatives of polyalkylene oxide polyaryl ethers. In some embodiments, the polyalkylene oxide polyaryl ether surfactant are anionic derivatives of polyalkylene oxide polyaryl ethers.

[0151] In some embodiments, the combination, mixture, or composition comprises at least two stabilizing domains. In some embodiments, the two stabilizing surfactants are polyalkyleneoxy In some embodiments, the two stabilizing boundaries are two derivatives of isopropyl polyaryl ether. The surfactants are non-ionic derivatives of polyalkylene oxide polyaryl ethers and poly Includes anionic derivatives of real alkylene oxide polyaryl ethers.

[0152] In some embodiments, the non-ionic derivatives of polyalkylene oxide polyaryl ethers The entities are compounds having an aryl group substituted with at least two aromatic groups.

[0153] In some embodiments, the non-ionic derivatives of polyalkylene oxide polyaryl ethers The body has the following structures:

[0154] [ka] has.

[0155] In some embodiments, the non-ionic derivatives of polyalkylene oxide polyaryl ethers The body has the following structures:

[0156] [ka] has.

[0157] In some embodiments, anionic derivatives of polyalkylene oxide polyaryl ethers is a compound having an aryl group substituted with at least two aromatic groups.

[0158] In some embodiments, anionic derivatives of polyalkylene oxide polyaryl ethers The anion group of is phosphate (PO 4 ), phosphonates (PO 3 ), sulfonates (S O 3 ), and sulfate (SO 4 ) an anionic group selected from

[0159] Polyalkylene oxides include, but are not limited to, polyethylene oxide groups, poly may include propylene oxide, polybutylene oxide, and any combination thereof In some embodiments, the polyalkylene oxide group is polyethylene oxide. In an embodiment, the polyalkylene oxide group is polypropylene oxide.

[0160] Polyalkylene oxides include, but are not limited to, copolymers and homopolymers. Copolymers may include, but are not limited to, random polymers and block polymers. In some embodiments, the polyalkylene oxide group may include a dibromoalkylene oxide polymer. In some embodiments, the polyalkylene oxide group is a triblock copolymer. It is a copolymer.

[0161] In some embodiments, the polyalkylene oxide polyaryl ether is In some embodiments, the polyalkylene oxide is a styryl phenyl ether. The silyl polyaryl ether is a polyalkylene oxide benzyl phenyl ether. In some embodiments, the polyalkylene oxide polyaryl ether is In some embodiments, the polyalkylene oxide is a polyalkylene oxide bisphenyl ether. The polyaryl ether is a polyalkylene oxide tristyryl phenyl ether. In some embodiments, the polyalkylene oxide polyaryl ether is In some embodiments, the polyalkylene oxide is distyryl phenyl ether. Polyoxyethylene distyryl phenyl ether is a It is.

[0162] In some embodiments, the polyalkylene oxide polyaryl ether is anionically stabilized. Anionic stabilizing surfactants include phosphonates and sulfonates. This refers to a compound having an anionic group.

[0163] In some embodiments, the salt comprises a cation. In some embodiments, the cation is sodium. calcium, potassium, ammonium, calcium, magnesium and combinations thereof The compound is selected from the group consisting of:

[0164] In some embodiments, anionic derivatives of polyalkylene oxide polyaryl ethers has the following structure:

[0165] [ka] has.

[0166] In some embodiments, anionic derivatives of polyalkylene oxide polyaryl ethers is a tristyrylphenol ethoxylate phosphate ester.

[0167] In some embodiments, the polyalkylene oxide polyaryl ether is a tristyryl Phenol ethoxylate phosphate ester. Preferably, tristyrylphenol Ethoxylate phosphate esters are a class of esters manufactured and sold by Solvay. The product is oprophor® 3D33.

[0168] In some embodiments, the polyalkylene oxide polyaryl ether has 54EO. 2,4,6-tri-(1-phenylethyl)phenol polyglycol ether Preferably, 2,4,6-tri-(1-phenylethyl)phenol having 54EO is used. Polyglycol Ether is an EPO manufactured and sold by Clariant. mulsogen(registered trademark) TS540.

[0169] In some embodiments, the polyalkylene oxide polyaryl ether is an ethoxylated Preferably, the ethoxylated tristyrylphenol is Soprophor® TS / 5 manufactured and sold by Solvay The answer is 4.

[0170] In some embodiments, the salt is sodium, potassium, ammonium, calcium, magnesium The cations are selected from the group consisting of nesium and combinations thereof.

[0171] Polyalkylene oxide polyaryl ether surfactants include, but are not limited to, , polyphenylethylphenol and tristyrylphenol.

[0172] Polyalkylene oxide polyaryl ether surfactants include, but are not limited to, , non-capped surfactants, end-capped surfactants, or combinations thereof. Good too.

[0173] In some embodiments, the combination, mixture, or composition comprises two or more stabilizing surfactants. The two stabilizing surfactants are a non-ionic polyalkylene oxide polyaryl ether Polyaryl ether surfactants and anionic polyalkylene oxide polyaryl ether surfactants In some embodiments, the nonionic surfactant is tristyrylphenol ethoxylate. In some embodiments, the anionic surfactant is a tristyrylphenol ethoxylate. It is a sylate phosphate ether.

[0174] In some embodiments, the combination, mixture, or composition comprises a tristyrylphenol ester. Contains tristyrylphenol ethoxylate and tristyrylphenol ethoxylate phosphate ether .

[0175] In some embodiments, the nonionic polyalkylene oxide polyaryl ether is It is a compound having an ether group substituted with at least two groups containing an aromatic ring.

[0176] In some embodiments, the polyalkylene oxide group is polyoxyethylene. In embodiments, the polyalkylene oxide group is polyoxypropylene. In one embodiment, the polyalkylene oxide group is a block copolymer of polyoxyethylene. In some embodiments, the polyalkylene oxide group is a block of polyoxypropylene. It is a copolymer.

[0177] Polyalkylene oxides include, but are not limited to, polyethoxylated groups, polypro The copolymer may include polyoxylated groups, polybutoxylated groups, and any combination thereof.

[0178] Polyalkylene oxides include, but are not limited to, copolymers and homopolymers. may include:

[0179] Copolymers include, but are not limited to, random polymers and block polymers. It may include.

[0180] In some embodiments, the polyalkylene oxide polyaryl ether is In some embodiments, the polyalkylene oxide is tristyryl phenyl ether. Oxidotristyrylphenyl ether is a polyoxyethylene tristyrylphenyl ether. In some embodiments, the polyalkylene oxide is a tristyrylphenyl ether. ether is polyoxyethylene polyoxypropylene tristyryl phenyl ether .

[0181] In some embodiments, the polyalkylene oxide polyaryl ether is In some embodiments, the polyalkylene oxide is distyryl phenyl ether. Polyoxyethylene distyryl phenyl ether is a It is.

[0182] In some embodiments, the non-ionic derivatives of polyalkylene oxide polyaryl ethers The body is a tristyrylphenol ethoxylate phosphate ester.

[0183] In some embodiments, the stabilizing surfactant is tristyrylphenol polyethylene glycol. It is a derivative of cholesteryl.

[0184] In some embodiments, the stabilizing surfactant is tristyrylphenol polyethylene glycol. It is an anionic derivative of cholesteryl ether.

[0185] In some embodiments, the stabilizing surfactant is tristyrylphenol polyethylene glycol. It is a non-ionic derivative of cholesteryl ether.

[0186] In some embodiments, the combination, mixture, or composition comprises two stabilizing surfactants. The two stabilizing surfactants were Soprophor 3D33 and Sopropho r TS / 54 (TSP54).

[0187] In some embodiments, the combination, mixture, or composition comprises two stabilizing surfactants. Both stabilizing surfactants are derivatives of polyalkylene oxide polyaryl ethers. In some embodiments, the combination, mixture, or composition comprises two stabilizing surfactants. The stabilizing surfactant is a non-isopropyl ether of polyalkylene oxide polyaryl ether. One stabilizing surfactant is a polyalkylene oxide polyaryl ether. It is an anionic derivative of

[0188] In some embodiments, the combination, mixture, or composition comprises at least two stabilizing interfaces. The at least one stabilizing surfactant is a polyalkylene oxide polyaryl and at least one stabilizing surfactant is a nonionic derivative of a diphenyl ether. It is an anionic derivative of olefin oxide polyaryl ether.

[0189] In some embodiments, the combination, mixture, or composition comprises two stabilizing surfactants. The stabilizing surfactant is a nonionic derivative of polyalkylene oxide polyaryl ether. One stabilizing surfactant is an anionic surfactant of polyalkylene oxide polyaryl ether. It is an on derivative.

[0190] In some embodiments, the stabilizing surfactant is Soprophor 3D33.

[0191] In some embodiments, the stabilizing surfactant is tristyrylphenol ethoxylate phosphorus. It is an acid ester.

[0192] In some embodiments, the polyalkylene oxide polyaryl ether is available from Solvay The camera is the Soprophor 3D33 manufactured by the company.

[0193] In some embodiments, the polyalkylene oxide polyaryl ether is Claria The product is Emulsogen TS540 manufactured by nt.

[0194] In some embodiments, the polyalkylene oxide polyaryl ether is available from Solvay The model is the Soprophor TS / 54.

[0195] In some embodiments, the salt containing a cation is sodium, potassium, ammonium, or calcium. The inorganic filler is selected from the group consisting of calcium, magnesium and combinations thereof.

[0196] Polyaryls include, but are not limited to, polyphenylethylphenols and triphenylphenylphenols. It may refer to styrylphenol.

[0197] Polyalkylene oxide polyaryl ether surfactants are non-capped surfactants , end-capped surfactants, or combinations thereof.

[0198] In some embodiments, the surfactant combination comprises a non-ionic polyalkylene oxide poly Aryl ether surfactants and the anionic polyalkylene oxide polyaryl ether world. In some embodiments, the non-ionic surfactant is a mixture of tristilbene and a surfactant. In some embodiments, the anionic surfactant is a triphenylphenol ethoxylate. It is a styrylphenol ethoxylate phosphate ether.

[0199] In some embodiments, the surfactant combination comprises a tristyrylphenol ethoxylate and tristyrylphenol ethoxylate phosphate ether.

[0200] In some embodiments, the nonionic polyalkylene oxide polyaryl ether is It is a compound having an ether group substituted with at least two groups containing an aromatic ring.

[0201] In some embodiments, the polyalkylene oxide group is polyoxyethylene. In embodiments, the polyalkylene oxide group is polyoxypropylene. In one embodiment, the polyalkylene oxide group is a block copolymer of polyoxyethylene. In some embodiments, the polyalkylene oxide group is a block of polyoxypropylene. It is a copolymer.

[0202] Polyalkylene oxides include, but are not limited to, polyethoxylated groups, polypro The copolymer may include polyoxylated groups, polybutoxylated groups, and any combination thereof.

[0203] Polyalkylene oxides include, but are not limited to, copolymers and homopolymers. may include:

[0204] Copolymers include, but are not limited to, random polymers and block polymers. It may include.

[0205] In some embodiments, the polyalkylene oxide polyaryl ether is In some embodiments, the polyalkylene oxide is tristyryl phenyl ether. Oxidotristyrylphenyl ether is a polyoxyethylene tristyrylphenyl ether. In some embodiments, the polyalkylene oxide is a tristyrylphenyl ether. ether is polyoxyethylene polyoxypropylene tristyryl phenyl ether .

[0206] In some embodiments, the polyalkylene oxide polyaryl ether is In some embodiments, the polyalkylene oxide is distyryl phenyl ether. Polyoxyethylene distyryl phenyl ether is a It is.

[0207] In some embodiments, the non-ionic derivatives of polyalkylene oxide polyaryl ethers The body is a tristyrylphenol ethoxylate phosphate ester.

[0208] In some embodiments, the stabilizing surfactant is Emulsogen TS540.

[0209] In some embodiments, the non-ionic derivative of the surfactant is Emulsogen TS5 It is 40.

[0210] In some embodiments, the stabilizing surfactant is Soprophor TS / 54.

[0211] In some embodiments, the non-ionic derivatives of polyalkylene oxide polyaryl ethers The body is Soprophor TS / 54.

[0212] In some embodiments, the stabilizing surfactant is tristyrylphenol polyethylene glycol. It is an anionic derivative of cholesteryl ether.

[0213] In some embodiments, the stabilizing surfactant is tristyrylphenol polyethylene glycol. It is a non-ionic derivative of cholesteryl ether.

[0214] In some embodiments, the combination, mixture, or composition comprises a stabilization system.

[0215] In some embodiments, the compound of Formula I and the polyalkylene oxide polyaryl ether The weight ratio of the non-ionic derivative is from 25:1 to 10:1. The weight ratio of the compound to the anionic derivative of polyalkylene oxide polyaryl ether is , 25:1 to 10:1.

[0216] In some embodiments, the combination, mixture, or composition contains a botanically acceptable azidophyte. It further includes hubant.

[0217] In some embodiments, the botanically acceptable adjuvant is (i) polyalkylene oxide alkyl ethers, (ii) siloxane polyalkylene oxide copolymers, (iii) esters of fatty acids, (iv) Vinylpyrrolidone and its derivatives, and (v) Sugar surfactants is selected from the group consisting of:

[0218] In some embodiments, the polyalkylene oxide alkyl ether is a polyalkoxyl It is a fluorinated alcohol.

[0219] In some embodiments, the alkyl of the polyalkylene oxide alkyl ether is Including, but not limited to, carbohydrate chains containing C1-C26.

[0220] In some embodiments, the alcohol of the polyalkoxylated alcohol is not limited to However, it contains carbohydrate chains of C1 to C26.

[0221] In some embodiments, the alkyl of the polyalkylene oxide alkyl ether is This includes, but is not limited to, short and long carbohydrate chains.

[0222] Carbohydrate chains include, but are not limited to, saturated chains, unsaturated chains, branched chains and unbranched chains. Can be pointed out.

[0223] In some embodiments, short chain refers to C1-C8. In some embodiments, long chain refers to C9-C It refers to 26.

[0224] In some embodiments, the polyalkylene oxide can be, but is not limited to, polyethylene oxide. polypropylene oxide, polybutylene oxide, or combinations thereof Refers to...

[0225] In some embodiments, the polyalkylene oxide can be, but is not limited to, a copolymer. Copolymers include block copolymers such as polyethylene oxide-polypropylene oxide. copolymers, and / or random copolymers such as ethylene oxide-propylene oxide In some embodiments, the polyalkylene oxide block copolymer is a dialkylene oxide block copolymer. In some embodiments, the polyalkylene oxide block copolymer is The polymer is a triblock copolymer.

[0226] In some embodiments, the triblock copolymer is a polyethylene oxide / polypropylene triblock copolymer. The polymer is polyethylene oxide / polyethylene oxide.

[0227] In some embodiments, the polyalkylene oxide alkyl ether is an alkyl tail cap. In some embodiments, the alkyl is a short carbohydrate, including but not limited to, Carbohydrate chains include, but are not limited to, saturated chains, unsaturated chains, and long carbohydrate chains. It can refer to saturated chain, branched chain and unbranched chain. In some embodiments, short chain refers to C1-C8. vinegar.

[0228] In some embodiments, the polyalkylene oxide alkyl ether is isotridecyla It is an alcohol polyglycol ether.

[0229] In some embodiments, the polyalkylene oxide alkyl ether is a C16 to C18 alkyl ether. Alcohol ethoxylate propoxylate ether.

[0230] In some embodiments, the C16 to C18 alcohol ethoxylate propoxylate esters are Tel is manufactured and sold by Akzo Nobel Agrochemicals. In some embodiments, the C16-C18 alcohol Ethoxylate Propoxylate Ether is manufactured and sold by BASF. Agnique (registered trademark) BP420.

[0231] In some embodiments, the polyalkylene oxide alkyl ether is an ethoxylated polyalkylene oxide. It is a propoxylated alcohol.

[0232] In some embodiments, the ethoxylated propoxylated alcohol is provided by Croda. In some embodiments, the compound is Synperonic 13 / 9, manufactured and sold by Ethoxylated Propoxylated Alcohols are manufactured and sold by Croda. The recommended product is Atplus PFA.

[0233] In some embodiments, the polyalkylene oxide alkyl ether is isotridecyla It is an alcohol polyglycol ether.

[0234] In some embodiments, the isotridecyl alcohol polyglycol ether is Clar Genapol X80 manufactured and sold by Iant. In this embodiment, isotridecyl alcohol polyglycol ether is manufactured and sold by BASF. The primary market share for 100,000 tonnes of erythritol is Trycol®, which is sold by the U.S. Department of Health and Human Services.

[0235] In some embodiments, the polyalkylene oxide alkyl ether may be used to improve the surface tension of the composition. and is effective in improving the diffusion of the compound of formula I on the leaves of plants. This reduction translates into less drift from the leaves.

[0236] In some embodiments, the siloxane polyalkylene oxide copolymer is an organically modified trialkylene oxide copolymer. Refers to siloxane.

[0237] In some embodiments, the siloxane polyalkylene oxide copolymer is from Evonik In some embodiments, the siloxane polyamide is Break Thru S233 manufactured by Eppendorf Chemical Industries, Ltd. The alkylene oxide copolymer is Silwett 077 from Momentive. do.

[0238] In some embodiments, the siloxane polyalkylene oxide copolymer is a combination, a mixture, Silicone surfactants are effective in reducing the surface tension of the mixture or composition. Reduction of surface tension and rapid spreading of the combination, mixture, or composition across a lipophilic surface It has been found to be an effective adjuvant for dispersion.

[0239] In some embodiments, the esters of fatty acids include, but are not limited to, alkyl esters of fatty acids. It may also include fatty esters and vegetable oils.

[0240] In some embodiments, the alkyl ester comprises a carbohydrate chain comprising C10 to C20.

[0241] In some embodiments, alkyl includes, but is not limited to, short carbohydrate chains.

[0242] Carbohydrate chains include, but are not limited to, saturated chains, unsaturated chains, branched chains and unbranched chains. Can be pointed out.

[0243] In some embodiments, short chain refers to C1-C8. The ester was Rhodaphac PA / 23 (an ethoxylated fatty acid ester) from Solvay. Alcohol phosphate ester) or Solvay's Alkamuls VO / 200 3 (ethoxylated (18EO) fatty acid).

[0244] In some embodiments, the adjuvant is an ethoxylated tridecyl alcohol or a poly Oxyethylene(9)isotridecanol.

[0245] In some embodiments, the vegetable oil includes, but is not limited to, vegetable oil. and its derivatives.

[0246] In some embodiments, the vegetable oil includes, but is not limited to, seed oil, palm oil, rapeseed oil, corn oil, Includes maize oil, soybean oil, palm oil and corn oil.

[0247] In some embodiments, the derivatives of vegetable oils include alkyl esters, polyalkylene oxides, and the like. Refers to...

[0248] Polyalkylene oxides include polyethylene oxide, polypropylene oxide, polybutene, "ethylene oxide" refers to ethylene oxides and combinations thereof.

[0249] In some embodiments, vegetable oils and their derivatives include, but are not limited to, rapeseed oil, These include coconut fatty acid esters of ethylated esters and polyglycerol ethers.

[0250] In some embodiments, the adjuvant is a combination of methylated seed oil and polyglycerol esters. It is a mixture.

[0251] In some embodiments, the rapeseed oil methyl ester is manufactured and sold by BASF. The Agnique ME 18 RDF is used.

[0252] In some embodiments, the polyalkylene oxide derivative of the vegetable oil is a polyglycerol ethylene glycol. It is a coconut fatty acid ester of ether.

[0253] In some embodiments, the coconut fatty acid esters of polyglycerol ethers are available from Clari. The Synergen GL5 is manufactured and sold by Ant.

[0254] In some embodiments, the esters of fatty acids provide better and more effective penetration of the compounds of formula I. In order to soften the surface properties of the leaves.

[0255] In some embodiments, the derivative of vinylpyrrolidone is vinylpyrrolidone and vinyl acetate ( It is a block copolymer of VP / VA.

[0256] In some embodiments, the block copolymer of vinylpyrrolidone and vinyl acetate is As The Sokalan VA64P is manufactured and sold by Hland.

[0257] In some embodiments, the block copolymer of vinylpyrrolidone and vinyl acetate is As The Agrimer VA6 is manufactured and sold by Hland.

[0258] In some embodiments, vinylpyrrolidone (PVP) and its derivatives have adhesive and To improve retention characteristics (e.g., rain resistance), the compounds of formula I may be enhanced to adhere to leaves. It is effective for

[0259] Examples of sugar surfactants include, but are not limited to, sorbitan esters, sucrose esters, They may include alkyl polyglycosides, and fatty acid glucamides.

[0260] In some embodiments, the glycosurfactant is an alkyl or fatty acid glucamide derivative. do.

[0261] In some embodiments, the sugar surfactant is an alkyl glucamide.

[0262] In some embodiments, the fatty acid glucamide is a C8 / C10 fatty acid glucose amide. do.

[0263] In some embodiments, the C8 / C10 fatty acid glucose amide is available from Glariant. Synergen GA.

[0264] In some embodiments, the sugar surfactant is sorbitan and its derivatives.

[0265] In some embodiments, the derivatives of sorbitan include polyethylene oxide derivatives and fats. It is an acid ester.

[0266] In some embodiments, the sorbitan is a di- or tri-fatty acid ester. In the form, sorbitan derivatives are polyethylene glycols containing 20 to 80 ethylene oxide groups. It is a tetrahydrofuran oxide derivative.

[0267] In some embodiments, the derivative of sorbitan is Tween 80.

[0268] In some embodiments, the sugar surfactant improves the penetration of the compound of Formula I through the leaf surface. This affects the leaf surface to produce

[0269] In some embodiments, the combination, mixture, or composition comprises a multi-adjuvant system. A multi-adjuvant system refers to a blend or any combination of adjuvants.

[0270] In some embodiments, the combination, mixture, or composition comprises at least two Ajuva species. In some embodiments, the combination, mixture, or composition comprises at least three The adjuvant is

[0271] In some embodiments, the blend of adjuvants includes, but is not limited to, alkyl Includes combinations of fatty acid esters and fatty alcohol alkoxylates.

[0272] In some embodiments, the alkyl fatty acid ester and the fatty alcohol alkoxylate The combination is Synergen SOC manufactured and sold by Clariant. It is.

[0273] In some embodiments, the alkyl fatty acid ester and the fatty alcohol alkoxylate The combination is FOP manufactured and sold by Clariant.

[0274] In some embodiments, the adjuvant blend may include, but is not limited to, vegetable oils and and / or its derivatives in combination with sugar surfactants.

[0275] In some embodiments, the combination, mixture, or composition comprises a pH adjuster.

[0276] In some embodiments, the pH adjusting agent may include, but is not limited to, a buffer, a base and / or Alternatively, it may contain an acidifying agent.

[0277] In some embodiments, the pH adjuster is an acid. In some embodiments, the pH adjuster is a base. It is.

[0278] In some embodiments, the pH adjuster is a mixture of at least one base and at least one acid. It is a mixture.

[0279] In some embodiments, the pH adjusting agent is a buffering agent.

[0280] A buffer refers to a combination of an acid and a base. Acids include, but are not limited to, organic acids and Bases include, but are not limited to, organic bases and inorganic bases.

[0281] Organic acids include, but are not limited to, citric acid, formic acid, acetic acid, propionic acid, butyric acid, Examples of suitable carboxylic acids include oxalic acid, lactic acid, malic acid, and benzoic acid.

[0282] Inorganic acids include, but are not limited to, hydrochloric acid, nitric acid, phosphoric acid, sulfuric acid, and boric acid. Some examples include:

[0283] Organic bases include, but are not limited to, primary and secondary amines, pyridine, imidazole and any combination thereof.

[0284] In some embodiments, the pH adjuster is potassium dihydrogen phosphate.

[0285] In some embodiments, the pH adjuster is disodium monohydrogen phosphate and potassium dihydrogen phosphate. It is a combination of.

[0286] The present invention provides a composition comprising any one of the combinations or mixtures disclosed herein. provide.

[0287] The present invention relates to a method for producing a compound comprising: (i) an amount of a compound of formula I;

[0288] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from The present invention provides a fungicide composition comprising:

[0289] The present invention relates to a method for producing a compound comprising: (i) an amount of a compound of formula I;

[0290] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from The present invention provides a synergistic fungicide composition comprising:

[0291] The present invention relates to a method for producing a compound comprising: (i) an amount of a compound of formula I;

[0292] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from A fungicide composition comprising: The composition is adapted to treat a plant or a locus of a plant against fungal infection, more effective than the same amount applied alone, A microbicidal composition is provided.

[0293] The present invention relates to a method for producing a compound comprising: (i) an amount of a compound of formula I;

[0294] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from A fungicide composition comprising: A given amount of a compound of formula I and a given amount of a fungicide (A), when applied together, reduces the fungal infection In treating plants or plant sites against each other, the same amount of each fungicide was applied alone. It is more effective if A microbicidal composition is provided.

[0295] The present invention relates to a method for producing a compound comprising: (i) an amount of a compound of formula I;

[0296] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from A fungicide composition comprising: The amount of the compound of formula I used is preferably 0.01 to 0.15% by weight, more preferably 0.1 to 0.25% by weight, and more preferably 0.2 to 0.5% by weight. Less than effective and / or The amount of fungicide (A) used is the bactericidal effect of the fungicide (A) when the fungicide (A) is used alone. Less effective than A microbicidal composition is provided.

[0297] In some embodiments, the composition comprises a compound of formula I in an amount of about 0.1 part by weight based on the total weight of the composition. % to 90% by weight, preferably about 0.1% to 20% by weight based on the total weight of the composition. Contains in amounts ranging from.

[0298] In some embodiments, the composition contains about 0.1 parts by weight of the fungicide (A) based on the total weight of the composition. % to 90% by weight, preferably about 0.1% to 20% by weight based on the total weight of the composition. Contains in amounts ranging from.

[0299] In some embodiments, the amount of the compound of formula I in the composition is about 0.05 to about 0.05 based on the total weight of the composition. .1% by weight, 0.5% by weight, 1% by weight, 1.5% by weight, 2% by weight, 2.5% by weight, 3% by weight %, 3.5%, 4%, 4.5% or 5% by weight to about 90%, 93% by weight %, 95%, 98% or 99% by weight.

[0300] In some embodiments, the amount of fungicide (A) in the composition is about 0.01 to about 0.01% by weight based on the total weight of the composition. .1% by weight, 0.5% by weight, 1% by weight, 1.5% by weight, 2% by weight, 2.5% by weight, 3% by weight %, 3.5%, 4%, 4.5% or 5% by weight to about 90%, 93% by weight %, 95%, 98% or 99% by weight.

[0301] In some embodiments, the amount of the compound of formula I in the composition is about 0.05 to about 0.05 based on the total weight of the composition. .1% by weight, 0.5% by weight, 1% by weight, 1.5% by weight, 2% by weight, 2.5% by weight, 3% by weight %, 3.5% by weight, 4% by weight, 4.5% by weight, 5% by weight, 10% by weight, 15% by weight, 20 Weight%, 25% by weight, 30% by weight, 35% by weight, 40% by weight, 45% by weight, 50% by weight, 55% by weight, 60% by weight, 65% by weight, 70% by weight, 75% by weight, 80% by weight, 85% by weight %, 90% by weight, or 95% by weight.

[0302] In some embodiments, the amount of fungicide (A) in the composition is about 0.01 to about 0.01% by weight based on the total weight of the composition. .1% by weight, 0.5% by weight, 1% by weight, 1.5% by weight, 2% by weight, 2.5% by weight, 3% by weight %, 3.5% by weight, 4% by weight, 4.5% by weight, 5% by weight, 10% by weight, 15% by weight, 20 Weight%, 25% by weight, 30% by weight, 35% by weight, 40% by weight, 45% by weight, 50% by weight, 55% by weight, 60% by weight, 65% by weight, 70% by weight, 75% by weight, 80% by weight, 85% by weight %, 90% by weight, or 95% by weight.

[0303] In some embodiments, the weight ratio of the compound of formula I to the fungicide (A) in the composition is about 400 In some embodiments, the compound of formula I and the bactericidal agent in the composition are in the range of 1:1 to 1:100. In some embodiments, the weight ratio of the agent (A) is in the range of about 200:1 to 1:100. The weight ratio of the compound of formula I to the fungicide (A) in the composition is about 50:1 to 1:50. In some embodiments, the weight ratio of the compound of formula I to the fungicide (A) in the composition is about 200: In some embodiments, the ratio of the compound of formula I and the fungicide in the composition is in the range of 1 to 1:100. In some embodiments, the weight ratio of (A) is in the range of about 10:1 to 1:10. The weight ratio of the compound of formula I to the fungicide (A) in the composition is within the range of about 5:1 to 1:5. In some embodiments, the weight ratio of the compound of formula I to the fungicide (A) in the composition is about 2:1 to 1. :2.

[0304] In some embodiments, the weight ratio of the compound of formula I to the fungicide (A) in the composition is 5:1 to In some embodiments, the weight ratio of the compound of formula I to the fungicide (A) in the composition is 30:1. The ratio is from 10:1 to 30:1. In some embodiments, the compound of formula I and the bactericidal agent in the composition are In some embodiments, the weight ratio of the agent (A) in the composition is 25:1 to 12.5:1. The weight ratio of the compound of formula I to the fungicide (A) is 25:1. The weight ratio of the compound of formula I to the fungicide (A) in the composition is 12.5:1. In this embodiment, the weight ratio of the compound of formula I to the fungicide (A) in the composition is 1:1.

[0305] In some embodiments, the composition further comprises a phytologically acceptable carrier.

[0306] In some embodiments, the composition further comprises a botanically acceptable adjuvant.

[0307] In some embodiments, the composition further comprises at least one insecticide.

[0308] In some embodiments, the compositions are formulated for dilution with water prior to application.

[0309] In some embodiments, the composition is a concentrated formulation and is suitable for application. In some embodiments, the composition may be dispersed in water or another liquid for application in a dust or liquid form. The compositions disclosed herein are granular and can then be applied without further processing. The compositions are conventional in the agricultural chemical art, but are novel and advantageous due to the synergistic effects of the compositions. It can be prepared according to the procedure which is important.

[0310] The compositions most often applied are aqueous suspensions or emulsions. Such water-soluble, water-suspendable, or emulsifiable preparations are usually available as solids, known as wettable powders, or is usually a liquid known as an emulsion, aqueous suspension, or thick suspension. The total vehicle and the fungicide used in formulating the synergist composition for delivery are The intended use is

[0311] Wettable powders that can be compressed to form water-dispersible granules are The synergistic composition comprises an intimate mixture of a carrier and an agriculturally acceptable surfactant. The concentration of the disclosed composition in the formulation is usually about 10% by weight to about 10% by weight based on the total weight of the formulation. About 90% by weight, more preferably about 25% by weight to about 75% by weight. The synergistic composition can be mixed with any finely divided solid.

[0312] As will be readily understood, any material to which the disclosed compositions may be added may be However, the antifungal activity of these synergistic mixtures or compositions may be improved by using The condition is that the desired utility is produced without significantly interfering.

[0313] How to use The present invention relates to a method of treating a plant, or a locus in which a plant is present, against a fungal infection, comprising the steps of: (i) an amount of a compound of formula I;

[0314] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from is applied to the plant or the area where the plant is located, thereby The method includes treating a fungal infection with

[0315] The present invention relates to a method of treating a plant, or a locus in which a plant is present, against a fungal infection, comprising the steps of: (i) an amount of a compound of formula I;

[0316] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from is applied to the plant or the area where the plant is located, thereby for fungal infection, In treating plants or plant sites against fungal infections, equal amounts of each fungicide should be used alone. more effective when applied, A method is provided.

[0317] The present invention relates to a method of treating a plant, or a locus in which a plant is present, against a fungal infection, comprising the steps of: (i) an amount of a compound of formula I;

[0318] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from is applied to the plant or the area where the plant is located, thereby for fungal infection, A given amount of a compound of formula I and a given amount of a fungicide (A), when applied together, reduces the rate of a fungal infection. In treating plants or plant sites against each other, the same amount of each fungicide was applied alone. It is more effective if A method is provided.

[0319] The present invention relates to a method of treating a plant, or a locus in which a plant is present, against a fungal infection, comprising the steps of: (i) an amount of a compound of formula I;

[0320] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from is applied to the plant or the area where the plant is located, thereby for fungal infection, The amount of the compound of formula I used is preferably 0.01 to 0.15% by weight, more preferably 0.1 to 0.25% by weight, and more preferably 0.2 to 0.5% by weight. Less than effective and / or The amount of fungicide (A) used is the bactericidal effect of the fungicide (A) when the fungicide (A) is used alone. Less effective than A method is provided.

[0321] The present invention also relates to a method of treating a plant or the locus in which the plant is located against a fungal infection. an effective amount of any one of the combinations, mixtures or compositions disclosed herein applying the above to the plant or to the area where the plant is present, thereby Also provided is a method comprising treating a subject for a fungal infection.

[0322] In some embodiments, the method includes treating a plant or a locus in which a plant is present against a fungal infection. more effective than each fungicide applied alone at the same amount.

[0323] In some embodiments, the amount of the compound of formula I and the amount of the fungicide (A) are applied together. When used, each fungicide is effective in treating plants or plant-containing areas against fungal infections. It is more effective than the same amount of the agent applied alone.

[0324] In some embodiments, the amount of the compound of formula I used is the same as when the compound of formula I is used alone. In some embodiments, the amount of fungicide (A) used is less than the fungicidally effective amount of the compound of formula I. , which is less than the germicidal effective amount of the germicide (A) when the germicide (A) is used alone.

[0325] In some embodiments, the methods include controlling fungal infection of a plant or a locus in which the plant is present. is effective for.

[0326] In some embodiments, controlling a fungal infection is achieved by administering to a plant or a site where the plant resides. In some embodiments, controlling a fungal infection includes controlling a fungal disease in which the fungus infects the plant. includes controlling plant or soil diseases caused by phytopathogenic fungi. In some embodiments, controlling fungal infection is achieved by administering to the plant or to a location where the plant is present. In some embodiments, controlling a fungal infection includes controlling a fungal infestation of the In some embodiments, the method includes: reducing fungal infection in the plant or in a locus where the plant is present. Controlling fungal infections is a method for preventing plant or soil diseases caused by phytopathogenic fungi. This includes treating the mind.

[0327] In some embodiments, the methods include protecting a plant or a locus in which the plant is located against fungal infection. It is effective to

[0328] In some embodiments, protecting a plant or a location where a plant resides against fungal infection. Some embodiments include protecting a plant or a site where a plant is present against fungal infestation. In the form of, protecting a plant or the place where the plant is located against fungal infection is In some embodiments, the plant or the locus where the plant is located is protected from fungal disease. Protecting plant sites against fungal infections is a This includes preventing fungal infections in the affected areas.

[0329] In some embodiments, the method comprises administering an effective amount of a combination, mixture, or comprises applying any one of the compositions to the propagation material of the plant. The method includes administering to a subject a therapeutically effective amount of any one of the combinations, mixtures, or compositions disclosed herein. The method includes applying any one of the compounds to the seeds and / or seedlings of a plant.

[0330] In some embodiments, the method comprises administering to a subject a combination, mixture, or composition disclosed herein. In some embodiments, the method includes the protective application of any one of the methods described herein. The therapeutic application of any one of the combinations, mixtures, or compositions disclosed in include.

[0331] In some embodiments, the method includes the protective application of a compound of formula I and a fungicide (A). In some embodiments, the method includes the therapeutic application of a compound of formula I and a fungicide (A). include.

[0332] In some embodiments, the fungal infestation includes preventing fungal infestation of a plant, seed, or seedling. In some embodiments, the fungal infestation is controlled by the introduction of fungal It is controlled by treating the insult.

[0333] The present invention also provides a method for controlling plant diseases caused by plant pathogenic fungi, comprising: In one embodiment, the plant, the propagation material of the plant, or the locus of the plant is treated with an effective amount of any one of the compounds disclosed herein. and contacting the plant with any one of the combinations listed in the above table, thereby controlling the plant disease. A method is also provided.

[0334] The present invention also relates to a method for controlling fungal infestation in a plant, seed or seedling, comprising the steps of: Any one of the disclosed combinations may be applied to plants, seeds, seedlings, and / or loci in which the plants are present. to thereby treat or prevent fungal infestation of the plant, seed or seedling. This document also provides a method for

[0335] The present invention also relates to a method for controlling fungal infestation in a plant, seed or seedling, comprising the steps of: Any one of the disclosed compositions or mixtures may be applied to plants, seeds, seedlings, and / or Apply to the area where plants are present, thereby controlling fungal infestation of the plants, seeds or seedlings. Also provided is a method comprising:

[0336] The present invention also relates to treating plants, seeds or seedlings to produce plants that are resistant to fungal infestation. A method comprising administering any one of the compositions or mixtures disclosed herein to a plant. , a seed adapted to produce a plant, a seedling adapted to produce a plant, or a planting The aim is to apply the compound to areas where fungal infections are present, thereby producing plants that are resistant to fungal invasion. A method including the steps of:

[0337] The present invention also provides a method for protecting a plant from fungal infestation, comprising administering to said plant a composition as disclosed herein. The plant may be treated with any of the following substances or mixtures: by applying it to seeds or seedlings adapted to grow fungi, thereby protecting the plants from fungal infestation. The present invention also provides a method for detecting a stoichiometric amount of ...

[0338] The present invention also provides plants that are resistant to fungal infestation and adapted to produce plants. A seed, a seedling adapted to produce a plant, or the locus in which the plant resides is also referred to as a "seed" in the present specification. Treated with any one of the compositions or mixtures shown.

[0339] The present invention also relates to a plant seed or a plant adapted to produce a plant resistant to fungal infestation. Seedlings are also provided, and the plant seeds or seedlings may be cultured with any of the compositions or mixtures disclosed herein. Treated with one of the following:

[0340] The present invention also provides a method for controlling fungal infestation in plants, comprising administering to a subject a composition or composition as described herein. or mixtures are applied to soil, plants, roots, leaves, seeds, fungal sites, and / or where infestation is to be prevented, thereby preventing fungal infestation of plants. Also provided is a method that includes controlling.

[0341] The present invention also relates to a method for controlling fungal infections in plants and / or soil comprising the steps of: Any one of the compositions or mixtures described in the above can be applied to soil, plants, roots, leaves, seeds, fungi, etc. where they are present and / or where their infestation is to be prevented, thereby Also provided are methods that include controlling fungal infection of objects and / or soil.

[0342] The present invention also provides a method for controlling a plant disease caused by a plant pathogenic fungus, comprising the steps of: The plant, plant propagation material, or locus in which the plant is present is treated with (i) a predetermined amount of a compound of formula I,

[0343] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from thereby controlling the plant disease.

[0344] In some embodiments, the plant disease is controlled by protecting the plant from the plant disease. In some embodiments, the plant disease is controlled by treating the plant disease.

[0345] The present invention also provides a method for controlling fungal infestation in a plant, seed or seedling, comprising the steps of: applying to the location of the seedling, and / or plant (i) a predetermined amount of a compound of formula I;

[0346] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from and thereby controlling fungal infestation of the plant, seed or seedling. Provide.

[0347] In some embodiments, the fungal infestation includes preventing fungal infestation of a plant, seed, or seedling. In some embodiments, the fungal infestation is controlled by the introduction of fungal It is controlled by treating the insult.

[0348] The present invention also provides a method for protecting a plant, seed or seedling from fungal infestation, comprising the steps of: applying to the location of the plant, seedling, and / or plant (i) a predetermined amount of a compound of formula I;

[0349] [ka] and (ii) a prescribed amount of fluindapyr, pydiflumetofen, flumetofen, mefentrifluconazole, impilfluki From the group consisting of inpyrfluxam, isofetamide, and Qi inhibitors At least one fungicide (A) selected from and thereby protecting the plant, seed or seedling from fungal infection. Provide.

[0350] In some embodiments, the method includes the protective application of a compound of formula I and a fungicide (A). In some embodiments, the method includes the therapeutic application of a compound of formula I and a fungicide (A). include.

[0351] In some embodiments, the method includes administering a compound of formula I and a fungicide (e.g., A). In some embodiments, the method includes applying A) before symptoms of fungal disease are exhibited. In some embodiments, the method includes applying a compound of formula I and a fungicide (A). This involves applying a compound of formula I and a fungicide (A) when the disease severity is low.

[0352] In some embodiments, the method comprises administering a compound of formula I and a fungicide ( A). In some embodiments, the method includes applying A) after symptoms of fungal disease are exhibited. The method includes applying a compound of formula I and a fungicide (A).

[0353] In some embodiments, the method is effective in reducing leaf necrosis. In some embodiments, leaf necrosis is reduced by at least 10%. In some embodiments, leaf necrosis is reduced by at least 50%. In some embodiments, leaf necrosis is reduced by at least 75%.

[0354] In some embodiments, the efficacy of the method is at least partially achieved from application of the compound of formula I and the fungicide (A). In some embodiments, the efficacy of the method is evaluated after at least one week. and is evaluated at least two weeks after application of the fungicide (A). The efficacy of the method is evaluated at least 3 weeks after application of the compound of formula I and the fungicide (A). In some embodiments, the efficacy of the method is determined by the application of the compound of formula I and the fungicide (A). The patients will be evaluated at least 4 weeks after the procedure.

[0355] In some embodiments, the compound of formula I and the fungicide (A) are applied simultaneously.

[0356] In some embodiments, the compound of formula I and the fungicide (A) are applied contemporaneously.

[0357] In some embodiments, the compound of formula I and the fungicide (A) are applied sequentially.

[0358] In some embodiments, the compound of formula I and the fungicide (A) are applied separately.

[0359] In some embodiments, the compound of formula I and the fungicide (A) are applied together.

[0360] In some embodiments, the compound of formula I and the fungicide (A) are mixed together as a tank mix. In some embodiments, the compound of formula I and the fungicide (A) are combined in a single composition. In some embodiments, the compound of formula I and the fungicide (A) are formulated as two separate They are formulated as individual compositions.

[0361] In some embodiments, the compound of formula I and the fungicide (A) are combined in the combination disclosed herein. The composition may be applied in one of the following forms: a powder, a mixture, or a composition.

[0362] In some embodiments, the compound of formula I and the fungicide (A) are administered to a part of a plant, adjacent to the plant. the area in contact with the plant, the soil adjacent to the plant, any surface adjacent to the plant, It applies to any surface, seed, and / or equipment used in agriculture that comes into contact with In some embodiments, the compound of formula I and the fungicide (A) are administered at the site where the plant is present, in the vicinity of the plant, This applies to areas where the product is in contact with, or in the presence of, fungi, or in close proximity to fungi. In the form, the compound of formula I and the fungicide (A) are applied to the soil in which the plants grow. In this embodiment, the compound of formula I and the fungicide (A) are applied to the soil in which the plants are to be grown. It is used.

[0363] In some embodiments, the compound of formula I and the fungicide (A) are applied at the time of sowing.

[0364] In some embodiments, the compound of formula I and the fungicide (A) are appropriately applied 1 to 60 days after sowing. It is used.

[0365] In some embodiments, the compound of formula I and the fungicide (A) are suitably applied 1 to 9 months after sowing. It is used.

[0366] In some embodiments, the compound of formula I and the fungicide (A) are applied at one time during the growing season. can be.

[0367] In some embodiments, the compound of formula I and the fungicide (A) are administered at least once during the growing season. times.

[0368] In some embodiments, the compound of formula I and the fungicide (A) are applied two or more times during the growing season. will be done.

[0369] In some embodiments, the compound of formula I and the fungicide (A) are applied as a soil application. In some embodiments, the compound of formula I and the fungicide (A) are applied as a foliar application.

[0370] In some embodiments, the compound of formula I is applied in an amount of from 1 g / ha to 500 g / ha. In some embodiments, the compound of formula I is applied in an amount of from 5 g / ha to 120 g / ha. In some embodiments, the compound of formula I is applied in an amount of from 1 g / ha to 100 g / ha. In some embodiments, the compound of formula I is applied in an amount of from 1 g / ha to 75 g / ha. In some embodiments, the compound of formula I is applied in an amount of from 1 g / ha to 50 g / ha. In some embodiments, the compound of formula I is applied in an amount of from 1 g / ha to 25 g / ha. In some embodiments, the compound of formula I is applied in an amount of from 1 g / ha to 15 g / ha. In an embodiment, the compound of formula I is applied in an amount of from 2 g / ha to 13 g / ha. In an embodiment, the compound of formula I is applied in an amount of from 5 g / ha to 10 g / ha.

[0371] In some embodiments, the compound of formula I is applied in an amount of about 5 g / ha. In some embodiments, the compound of formula I is applied in an amount of about 6.25 g / ha. The compound of formula I is applied in an amount of about 10 g / ha. In some embodiments, the compound of formula I In some embodiments, the compound of formula I is applied at a rate of about 7 In some embodiments, the compound of formula I is applied at a rate of about 100 g / ha. In some embodiments, the compound of formula I is applied at a rate of about 125 g / ha. In some embodiments, the compound of formula I is applied in an amount of about 150 g / ha. In some embodiments, the compound of formula I is applied in an amount of about 300 g / ha. In this embodiment, the compound of formula I is applied in an amount of about 500 g / ha.

[0372] In some embodiments, the fungicide (A) is present in an amount of 0.0001 g / ha to 500 g / ha. In some embodiments, the fungicide (A) is applied at a concentration of 0.1 g / ha to 100 g / ha. In some embodiments, the fungicide (A) is applied in an amount of 0.1 g / ha to 75 g / ha. In some embodiments, the fungicide (A) is applied in an amount of 0.1 g / ha to 50 g / h In some embodiments, the fungicide (A) is applied in an amount of 0.1 g / ha to 25 g / ha. In some embodiments, the fungicide (A) is applied in an amount of 0.1 g / ha to 10 g / ha. In some embodiments, the fungicide (A) is applied in an amount of 0.1 g / ha to 5 g / ha. / ha. In some embodiments, the fungicide (A) is applied in an amount of 0.1 g / ha to 0. In some embodiments, the fungicide (A) is applied at a rate of 0.0001 g / ha. ha to 0.01 g / ha. In some embodiments, the fungicide (A) is applied in an amount of 0. In some embodiments, the fungicide is applied at a rate of 0.003 g / ha to 0.008 g / ha. (A) is applied in an amount of 0.1 g / ha to 150 g / ha. The fungicide (A) is applied in an amount of 0.1 g / ha to 1 g / ha.

[0373] In some embodiments, the fungicide (A) is applied in an amount of about 0.0003 g / ha. In some embodiments, the fungicide (A) is applied in an amount of about 0.001 g / ha. In some embodiments, the fungicide (A) is applied in an amount of about 0.002 g / ha. In some embodiments, the fungicide (A) is applied in an amount of about 0.008 g / ha. The fungicide (A) is applied in an amount of about 0.4 g / ha. In some embodiments, the fungicide (A ) is applied in an amount of about 6.25 g / ha. In some embodiments, the fungicide (A) is applied in an amount of about In some embodiments, the fungicide (A) is applied at a rate of about 12.5 g / ha. In some embodiments, the fungicide (A) is applied at a rate of about 75 g / ha. In some embodiments, the fungicide (A) is applied in an amount of about 100 g / ha. In some embodiments, the fungicide (A) is applied in an amount of about 125 g / ha. In some embodiments, the fungicide (A) is applied in an amount of about 150 g / ha. The fungicide (A) is applied in an amount of about 300 g / ha. In some embodiments, the fungicide (A ) is applied at a rate of approximately 500 g / ha.

[0374] In some embodiments, fluindapyr is at a concentration of 5 g / ha to 150 g / ha. In some embodiments, fluindapyr is administered in an amount of 0.1 g / In some embodiments, fluindapyr is applied at a rate of 100-150 g / ha. apyr) is applied at a rate of 0.1 g / ha to 1 g / ha. Fluindapyr is applied at a rate of approximately 0.4 g / ha.

[0375] In some embodiments, pydiflumetofen is at 0.0001 g / h In some embodiments, pydiflumetofen is applied at a rate of from about 150 g / ha. Flumetofen is applied at a rate of 0.0001g / ha to 0.01g / ha. In an embodiment, pydiflumetofen is administered in an amount of about 0.0003 g / ha. In some embodiments, pydiflumetofen is present in an amount of about 0.0 In some embodiments, pydiflumetofen is applied at a rate of 0.01 g / ha. ofen) is applied at a rate of about 0.002 g / ha. Fen (pydiflumetofen) is applied at a rate of approximately 0.008 g / ha.

[0376] In some embodiments, mefentrifluconazole is administered at a dose of 5 g. In some embodiments, mefentriflucona is applied at a rate of 100 g / ha to 150 g / ha. Mefentrifluconazole is applied at rates of 0.1g / ha to 150g / ha. In some embodiments, mefentrifluconazole is administered at a dose of 0. It is applied at a rate of 1 g / ha to 1 g / ha. Mefentrifluconazole is applied at a rate of approximately 0.4 g / ha.

[0377] In some embodiments, inpyrfluxam is administered at a concentration of 5 g / ha to 150 g / ha. In some embodiments, inpyrfluxam is applied at a rate of 1 / ha. , applied at rates of 0.1g / ha to 150g / ha.

[0378] In some embodiments, isofetamide is administered at a dose of 5 g / ha to 150 g / ha. In some embodiments, isofetamide is administered in an amount of 0.1 g / ha~150g / ha is applied.

[0379] In some embodiments, the Qi inhibitor is applied in an amount of 5 g / ha to 150 g / ha. In some embodiments, the Qi inhibitor is applied in an amount of 0.1 g / ha to 150 g / ha. In some embodiments, the Qi inhibitor is applied in an amount of 0.1 g / ha to 1 g / ha. In some embodiments, the Qi inhibitor is applied in an amount of about 0.4 g / ha.

[0380] In some embodiments, fenpicoxamid is administered at a rate of 5 g / ha to 150 g / ha. In some embodiments, fenpicoxamid is applied at a rate of 1 / ha. In some embodiments, fenpicoside is applied in an amount of 0.1 g / ha to 150 g / ha. Fenpicoxamid is applied at a rate of 0.1g / ha to 1g / ha. In an embodiment, fenpicoxamid is applied at a rate of about 0.4 g / ha. do.

[0381] A combination, mixture or composition comprising a compound of formula I and a fungicide (A) as disclosed herein. When applied in the form of a mixture, the ratio at which the combination, mixture and / or composition is applied is , the particular type of fungus to be controlled, the degree of control required, and the time and Generally, the combinations, mixtures or compositions disclosed herein comprise: Apply at application rates between approximately 1 gram per hectare (g / ha) and approximately 2600 g / ha. It can be done.

[0382] The combinations, mixtures or compositions disclosed herein contain about 4% or more of the active ingredients. It may be applied at an application rate of between 0 g / ha and about 600 g / ha.

[0383] In some embodiments, the amount of the compound of formula I ranges from 1 g / ha to 500 g / ha. In some embodiments, the amount of the compound of formula I is 5 The combination, mixture or composition is applied in the range of 100 g / ha to 120 g / ha. In some embodiments, the amount of the compound of formula I ranges from 1 g / ha to 100 g / ha. In some embodiments, the amount of the compound of formula I is greater than or equal to 1 g / Combinations, mixtures or compositions ranging from 1000 g / ha to 75 g / ha are applied. In an embodiment, the amount of the compound of formula I is in the range of 1 g / ha to 50 g / ha. In some embodiments, the amount of the compound of formula I is 1 g / ha to 2 g / ha. In some embodiments, the combination, mixture or composition is applied in the range of 5 g / ha. is a combination, mixture or plant composition in which the amount of the compound of formula I is in the range of 1 g / ha to 15 g / ha. In some embodiments, the amount of the compound of formula I is from 2 g / ha to 13 g / h In some embodiments, the combination, mixture or composition is in the range of a. A combination, mixture or composition in which the amount of the compound is in the range of 5 g / ha to 10 g / ha. Applies.

[0384] In some embodiments, the amount of the compound of formula I is about 5 g / ha. In some embodiments, the amount of the compound of formula I is about 6.25 g / ha. In some embodiments, the amount of the compound of formula I is In some embodiments, the combination, mixture or composition is applied at a concentration of about 10 g / ha. is applied in an amount of about 12.5 g / ha of the compound of formula I. In some embodiments, the amount of the compound of formula I is about 75 g / ha. In some embodiments, the amount of the compound of formula I is about 100 g / h In some embodiments, the combination, mixture or composition is a compound of formula I. The combination, mixture or composition is applied in an amount of about 125 g / ha. In an embodiment, the amount of the compound of formula I is about 150 g / ha. In some embodiments, the amount of the compound of formula I is about 300 g / ha. In some embodiments, the amount of the compound of formula I is about 50 0 g / ha of the combination, mixture or composition is applied.

[0385] In some embodiments, the amount of fungicide (A) is in the range of 1 g / ha to 500 g / ha. A combination, mixture or composition is applied.

[0386] In some embodiments, the amount of fungicide (A) ranges from 0.1 g / ha to 100 g / ha. In some embodiments, the amount of the fungicide (A) is A combination, mixture or composition having a concentration in the range of 0.1 g / ha to 75 g / ha is applied. In some embodiments, the amount of fungicide (A) ranges from 0.1 g / ha to 50 g / ha. In some embodiments, the amount of the fungicide (A) is A combination, mixture or composition having a concentration in the range of 0.1 g / ha to 25 g / ha is applied. In some embodiments, the amount of fungicide (A) ranges from 0.1 g / ha to 10 g / ha. In some embodiments, the amount of the fungicide (A) is The combination, mixture or composition is applied in the range of 0.1 g / ha to 5 g / ha. In some embodiments, the amount of fungicide (A) is in the range of 0.1 g / ha to 0.7 g / ha. Any combination, mixture or composition may be applied.

[0387] In some embodiments, the amount of fungicide (A) is about 0.4 g / ha. In some embodiments, the amount of fungicide (A) is about 6.25 g / ha. In some embodiments, the combination, mixture or composition is applied, wherein the fungicide (A) is The combination, mixture or composition is applied in an amount of about 10 g / ha. In this embodiment, the combination, mixture or composition is one in which the amount of the fungicide (A) is about 12.5 g / ha. In some embodiments, the combination is applied in an amount of about 75 g / ha of the compound of formula I. The mixture or composition is applied. In some embodiments, the amount of the fungicide (A) is about 100 g. / ha of the combination, mixture or composition is applied. In some embodiments, the fungicide The combination, mixture or composition is applied in an amount of (A) of about 125 g / ha. In this embodiment, the combination, mixture or composition has an amount of fungicide (A) of about 150 g / ha. In some embodiments, a composition is applied in which the amount of fungicide (A) is about 300 g / ha. In some embodiments, the combination, mixture or composition is applied. In some embodiments, the amount of fungicide (A) is about The combination, mixture or composition is applied at 500 g / ha.

[0388] The combinations, mixtures and compositions disclosed herein are effective against a variety of fungal pathogens and It can be applied to control and / or prevent diseases associated therewith. In an embodiment, the fungal pathogen is Mycosphaerella graminicola, Septoria tritici, Puccinia triticina, and yellow rust of wheat Puccinia striiformis f. sp. tritici, Venturia inaequal is), Ustilago maydis, Uncinula necator , Rhynchosporium secalis, Magnaporche grisea ), Asian soybean rust fungus (Phakopsora pachyrhizi), wheat leaf spot fungus (Leptosphaer ia nodorum, wheat powdery mildew (Blumeria graminis f. sp. tritici), barley powdery mildew Powdery mildew fungus (Blumeria graminis f. sp. hordei), cucurbit powdery mildew fungus (Erysiphe citrifolia oracearum, Glomerella lagenarium, Cercospo ra beticola), Alternaria solani, Pyrenophora teres ), Ramularia, Peronospora spp., Gray mold fungus (Botrytis cinereal), and the banana black Sigatoka pathogen (Mycosphaerella fijiensis) It is one of them.

[0389] In some embodiments, the fungal pathogen is of the genus Septoria. In an embodiment, the fungal pathogen is Zymoseptoria tritici (SEPTTR). In some embodiments, the fungal pathogen is of the genus Rhynhosporium. In some embodiments, the fungal pathogen is of the genus Pyrenophora. In some embodiments, the fungal pathogen is Microduchium majus. In some embodiments, the fungal pathogen is of the genus Sclerotinia. In an embodiment, the fungal pathogen is Cercosporea beticola.

[0390] In some embodiments, the fungal disease is Leaf Blotch of Wheat (Wheat Leaf Mycosphaerella graminicola, anamorph, wheat pathogen Zymoseptoria tritici tici), Wheat Brown Rust (Puccinia tritici na), Stripe Rust (Puccinia striiformis f. sp. t ritici), Scab of Apple (Venturia inaequalis) ), Blister Smut of Maize (Ust ilago maydis), Powdery Mildew of Grapevine Barley scald (Rhyn chosporium secalis), Blast of Rice (Magnaporc he grisea), Rust of Soybean (Asian soybean rust fungus (Phakopso ra pachyrhizi), Glume Blotch of Wheat (Lept osphaeria nodorum), Powdery Mildew of Wheat Powdery mildew fungus (Blumeria graminis f. sp. tritici), powdery mildew fungus of barley (Powdery Mildew Powdery mildew of Barley (Blumeria graminis f. sp. hordei), Powdery Mildew of Cucurbits (Erysiphe citrifolia) choracearum), Anthracnose of Cucurbits (Glo merella lagenarium)), Leaf Spot of Beet (C ercospora beticola), Early Blight of Tomato (tomato ring spot fungus) (Alternaria solani), Net Blotch of Barley (Pyr enophora teres), Downy Mildew of vegetables (Common mold) (Peronospora spp.), Downy Mildew of Brassicas Peronospora spp.), Downy Mildew of Cucurbits (Tu Peronospora spp.), Gray Mold of Grape Botrytis cinereal), Gray Mold of Vegetables ( Botrytis cinereal, and Banana Black siga toka (Banana black Sigatoka pathogen (Mycosphaerella fijiensis)).

[0391] In some embodiments, the plant or soil disease is a leaf spot disease, brown rust, yellow rust, powdery mildew, or the like. Diseases include downy mildew, gray mold, Asian soybean rust, and black shiga. It is one of the types of toca disease.

[0392] In some embodiments, the plant is a crop plant. Methods of the invention include, but are not limited to, Monocotyledonous plants such as sugarcane, cereals, rice, maize (corn), and / or bicotyledonous plants dicotyledonous crops such as sugar beet or fodder beet; fruits (pomes, drupes, or soft fruits, such as apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, or blackberries); legumes (beans, lentils, peas, etc.) Bean, soybean, etc.); oilseed plants (rapeseed, mustard, poppy, olive, sunflower, yam, etc.) , castor oil plant, cocoa bean, or groundnut); cucumber plant (mallow, cucumber fiber plants (such as cotton, flax, hemp, or jute); citrus fruits (oranges, lemons, grapefruit, or mandarin oranges); vegetables (honey Greens, lettuce, cabbage, carrots, tomatoes, potatoes, cucurbits, or peppers moss, etc.); Lauraceae (avocado, cinnamon, or camphor, etc.); tobacco; nuts ;coffee;tea;vines;hops;durian;bananas;rubber plants;and ornamental plants Use on any crop, including flowers, shrubs, broadleaf trees, or evergreen trees, e.g. conifers. It is possible.

[0393] In some embodiments, the plant is a monocotyledonous plant, more preferably a cereal. In another particular embodiment, the cereal is wheat. In another particular embodiment, the cereal is triticale. In certain embodiments, the grain is rye. In other particular embodiments, the grain is oat. In a further embodiment, the cereal is barley. In another particular embodiment, the cereal is In another embodiment, the crop is rice. The crop is sugarcane. In yet another embodiment, the crop is corn.

[0394] In another embodiment, the crop plant is a dicotyledonous plant.

[0395] In one embodiment, the crop is rapeseed.

[0396] Any combination, mixture or composition disclosed herein is incorporated by reference in its entirety. Incorporated U.S. Patent Application Publication No. 2018-0000082 (published January 4, 2018) The composition may also be used as a seed treatment to prevent or control the plant pathogenic fungi described in .

[0397] In some embodiments, the combination, mixture, or composition of the present invention comprises at least one In some embodiments, the pesticide further comprises an additional pesticide. The compound is an insecticide, acaricide or nematocide.

[0398] In some embodiments, the combination, mixture, or composition of the present invention comprises at least one It further comprises a disinfectant.

[0399] In some embodiments, the fungicide is a fungicidal sterol biosynthesis inhibitor.

[0400] In some embodiments, the sterol biosynthesis inhibitor is prothioconazole, epoxiconazole. azole, cyproconazole, myclobutanil, prochloraz, metconazole, diphenazole Conazole, tebuconazole, tetraconazole, fenbuconazole, propiconazole le, fluquinconazole, flusilazole, flutriafol, and fenpropimol The compound is selected from the group consisting of

[0401] In some embodiments, the sterol biosynthesis inhibitor is prothioconazole, epoxiconazole. metconazole, difenoconazole, propiconazole, prochloraz, tetrazole Laconazole, tebuconazole, fenpropimorph, fenpropidin, ipconazole , triticonazole, spiroxamine, fenhexamid, and fenpyrazamine The compound is selected from the group consisting of:

[0402] In some embodiments, the sterol biosynthesis inhibitor is prothioconazole. In some embodiments, the sterol biosynthesis inhibitor is epoxiconazole. In some embodiments, the sterol biosynthesis inhibitor is cyproconazole. In some embodiments, the sterol biosynthesis inhibitor is myclobutanil. In some embodiments, the sterol biosynthesis inhibitor is difenoconazole. In some embodiments, the sterol biosynthesis inhibitor is propiconazole. In some embodiments, the sterol biosynthesis inhibitor is prochloraz. In some embodiments, the sterol biosynthesis inhibitor is tetraconazole. In some embodiments, the sterol biosynthesis inhibitor is tebuconazole. In some embodiments, the sterol biosynthesis inhibitor is fluquinconazole. In some embodiments, the sterol biosynthesis inhibitor is flutriafol. In some embodiments, the sterol biosynthesis inhibitor is fenpropimorph. In embodiments, the sterol biosynthesis inhibitor is fenpropidin. The sterol biosynthesis inhibitor is ipconazole. In some embodiments, the sterol biosynthesis inhibitor is triticonazole. In some embodiments, the sterol biosynthesis inhibitor is fenhexamid. In some embodiments, the sterol biosynthesis inhibitor is fenpyrazamine. In an embodiment, the sterol biosynthesis inhibitor is fenbuconazole.

[0403] In some embodiments, the fungicide is a succinate dehydrogenase inhibitor.

[0404] In some embodiments, the succinate dehydrogenase inhibitor is benzovindiflupyr, Nthiopyrad, Isopyrazam, Fluxapyroxad, Boscalid, Fluopyram, Vyxa fen, and penflufen.

[0405] In some embodiments, the succinate dehydrogenase inhibitor is benzovindiflupyr In some embodiments, the succinate dehydrogenase inhibitor is penthiopyrad. In some embodiments, the succinate dehydrogenase inhibitor is isopyrazam. In some embodiments, the succinate dehydrogenase inhibitor is fluxapyroxad. In some embodiments, the succinate dehydrogenase inhibitor is boscalid. In some embodiments, the succinate dehydrogenase inhibitor is fluopyram. In some embodiments, the succinate dehydrogenase inhibitor is bixafen. The enzyme inhibitor is penflufen.

[0406] In some embodiments, the fungicide is a strobilurin fungicide.

[0407] In some embodiments, the strobilurin fungicide is azoxystrobin, pyraclostridium sulphate, Robin, picoxystrobin, fluoxastrobin, trifloxystrobin, creso Selected from the group consisting of dimoxystrobin, dimoxystrobin, and orysastrobin .

[0408] In some embodiments, the strobilurin fungicide is azoxystrobin. In some embodiments, the strobilurin fungicide is pyraclostrobin. In some embodiments, the strobilurin fungicide is picoxystrobin. The fluoxastrobin fungicide is a strobilurin fungicide. The fungicide is trifloxystrobin. In some embodiments, the strobilurin fungicide is kresoxim-methyl. In some embodiments, the strobilurin fungicide is dimoxim-methyl. In some embodiments, the strobilurin fungicide is orysastrobin. be.

[0409] In some embodiments, the fungicide is a fungicidal multipoint inhibitor.

[0410] In some embodiments, the bactericidal multipoint inhibitor is mancozeb, chlorothalonil, folpet captan, metiram, maneb, propineb, copper hydroxide, copper octanoate, oxysalt Copper chloride, copper sulfate, copper sulfate (tribasic), man-copper, copper oxine, bis(3-phenylsalicylic acid) Copper thirate, copper zinc chromate, cuprous oxide, copper hydrazinium sulfate, and cuprovain. (cuprobam).

[0411] In some embodiments, the bactericidal multipoint inhibitor is mancozeb. The fungicidal multipoint inhibitor is chlorothalonil. In some embodiments, the fungicidal multipoint inhibitor is In some embodiments, the bactericidal multipoint inhibitor is captan. In embodiments, the bactericidal multipoint inhibitor is metiram. In some embodiments, the bactericidal multipoint inhibitor is propineb. In embodiments of the invention, the bactericidal multipoint inhibitor is copper hydroxide, copper octanoate, copper oxychloride, copper sulfate, Copper sulfate (tribasic), man-copper, copper oxine, copper bis(3-phenylsalicylate), Copper zinc chromate, cuprous oxide, copper hydrazinium sulfate, or cuprobam.

[0412] In some embodiments, the combination, mixture, or composition further comprises an insecticide.

[0413] In some embodiments, the insecticide is 2-(thiocyanatomethylthio)-benzothiazo , 2-phenylphenol, 8-hydroxyquinoline sulfate, amethoctrazine, amylase Rubrom, Antimycin, Ampelomyces quisqualis, Azacona Zol, azoxystrobin, Bacillus subtilis, Bacillus subtilis strain QST713, Benalaxyl, benomyl, benthiavalicarb isopropyl, benzylaminobenzenes Sulfonic acid (BABS) salts, bicarbonates, biphenyls, bismerthiazole, bitertanol , bixafen, blasticidin S, borax, Bordeaux mixture, boscalid, bromuconazo carbendazim, bupirimate, calcium polysulfide, captafol, captan, carbendazim, Carboxin, carpropamid, carvone, chlazafenone, chlorone , chlorothalonil, chlozolinate, Coniothyrium mintans itans), copper hydroxide, copper octanoate, copper oxychloride, copper sulfate, copper sulfate (tribasic), copper oxide Copper monophosphate, cyazofamid, cyflufenamid, cymoxanil, cyproconazole, cyprodi Nil, dazomet, debacarb, diammonium ethylenebis(dithiocarbamate), Dichlofluanid, dichlorophen, diclocymet, diclomedine, dicloran, diethyl Tofencarb, difenoconazole, difenzoquat ion, diflumetrim, dimethicone Tomorph, Dimoxystrobin, Diniconazole, Diniconazole M, Dinobuton, Di Nocap, diphenylamine, dithianon, dodemorph, dodemorph acetate, dodine, dodi free base, edifenphos, enestrobin, enestrobulin, epoxiconazole , ethaboxam, ethoxyquin, etridiazole, famoxadone, fenamidone, Fenarimol, fenbuconazole, fenfuram, fenhexamid, fenoxanil , fenpiclonil, fenpropidin, fenpropimorph, fenpyrazamine, tin, triphenyltin acetate, triphenyltin hydroxide, ferbam, ferimzone, Fluazinam, Fludioxonil, Flumorph, Fluopicolide, Fluopyram, Fluo fluoxastrobin, fluquinconazole, flusilazole, flusulfa mido, flutianil, flutolanil, flutriafol, fluxapyroxad, forpe , formaldehyde, fosetyl, fosetyl-aluminum, fuberidazole, furafen Xyl, furametpyr, guazatine, guazatine acetate, GY-81, hexachlorobene Zen, Hexaconazole, Hymexazole, Imazalil, Imazalil Sulfate, Imibenco Nazole, iminoctadine, iminoctadine triacetate, iminoctadine albesilate, Iodocarb, ipconazole, ipfenpyrazolone, iprobenfos, Iprodione, iprovalicarb, isoprothiolane, isopyrazam, isotianil, Sugamycin, Kasugamycin hydrochloride monohydrate, Kresoxim-methyl, Laminarin, Man Kappa, mancozeb, mandipropamide, maneb, mefenoxam, mepanipyrim, Mepronil, meptyldinocap, mercuric chloride, mercuric oxide, mercurous chloride, metalaxyl , Metalaxyl M, Metam, Metam Ammonium, Metam Potassium, Metam Sodium , metconazole, methasulfocarb, methyl iodide, methyl isothiocyanate, methyl metominostrobin, metrafenone, mildiomycin, myclobutanil, nabam , nitrotar isopropyl, nuarimol, octilinone, ofurace, oleic acid (fatty acid), orysastrobin, oxadixyl, copper oxine, oxpoconazole fumarate , oxycarboxin, pefurazoate, penconazole, pencycuron, penflufe Pentachlorophenol, Pentachlorophenyl Laurate, Penthiopyrad, Acetic Acid Phenylmercury, phosphonic acid, phthalide, picoxystrobin, polyoxin B, polyoxin Synthin, polyoxorim-D, potassium bicarbonate, potassium hydroxyquinoline sulfate Um, probenazole, prochloraz, procymidone, propamocarb, propamocarb Hydrochloride, Propiconazole, Propineb, Proquinazid, Prothioconazole, Pyraclovir Strobin, pyrametostrobin, pyraoxystrobin, pyrazophos, pyrizencarb , pyributicarb, pyrifenox, pyrimethanil, pyriophenone, pyroquilon, Noclamine, quinoxyfen, quintozene, Reynoutria sachaline extract nsis extract), sedaxane, silthiofam, simeconazole, sodium 2-phenyl Ruphenoxide, sodium bicarbonate, sodium pentachlorophenoxide, spiroxa Mine, Sulfur, SYP-Z048, Tar Oil, Tebuconazole, Tebufloquine, Tecnazen , tetraconazole, thiabendazole, thifluzamide, thiophanate methyl, thiram , tiadinil, tolclofos-methyl, tolylfluanid, triadimefon, triadimeno triazoxide, tricyclazole, tridemorph, trifloxystrobin, Riflumizole, Triforine, Triticonazole, Validamycin, Valifenalate, Valifenal, Vinclozolin, Zineb, Ziram, Zoxamide, Candida oleifera Candida oleophila, Fusarium oxysporum, Grifola frondosa Gliocladium spp., Phlebiopsis gigantea gantea), Streptomyces griseoviridis, Trichoderma spp., (RS)-N-(3,5-dichlorophenyl)- 2-(Methoxymethyl)succinimide, 1,2-dichloropropane, 1,3-dichloro -1,1,3,3-Tetrafluoroacetone hydrate, 1-chloro-2,4-dinitronaphthalene Talen, 1-chloro-2-nitropropane, 2-(2-heptadecyl-2-imidazoline -1-yl)ethanol, 2,3-dihydro-5-phenyl-1,4-dithiin, 1,1 ,4,4-tetraoxide, 2-methoxyethylmercuric acetate, 2-methoxyethylmercuric chloride , 2-methoxyethylmercuric silicate, 3-(4-chlorophenyl)-5-methylrhodanine, 4-(2-nitroprop-1-enyl)phenylthiocyanate, ampropylphos, a Nirazine, Adithiram, Barium polysulfide, Bayer 32394, Benodani, Benchi Nox, Bentallon, Benzamacryl, Benzamacryl-isobutyl, Benzamorph , binapacryl, bis(methylmercury) sulfate, bis(tributyltin) oxide, buthiobacter Cadmium calcium copper zinc chromate sulfate inc chromate sulfate), carbamorph, CECA, clobenziazone, chloraniforme Tan, chlorphenazole, chlorquinox, climbazole, bis(3-phenylsulfonyl) Licylate) Copper, Zinc Copper Chromate, Kufraneb, Copper Hydrazinium Sulfate, Kupropam, Cyclohexanone Raflamid, Sipendazole, Cyproflam, Decafentin, Dicloron, Diclozolin , diclobutrazol, dimethirimol, dinoktone, dinosulfone, dinoterbone, di Pyrithione, ditalimfos, dodicin, drazoxolone, EBP, ESBP, etaconazole ol, ethem, etilim, fenaminosulf, fenapanil, fenitropan, fluot Rimazole, flucarbanil, fluconazole, fluconazole-cis, flumecyclox cus, furophanate, glyodine, griseofulvin, halacrinate, Hercules3944, Hexylthiophos, ICIA0858, Isopamphos, I Sobarezion, Mebenil, Mecarbinzide, Metazoxolone, Metofluoxam, Methylwater Silver dicyandiamide, metsulfovax, milneb, mucochloric anhydride, micro Zoline, N-3,5-dichlorophenylsuccinimide, N-3-nitrophenyl itaco Nitrimide, Natamycin, N-Ethylmercurio-4-toluenesulfonanilide, Nitrimide Kelvis (dimethyldithiocarbamate), OCH, phenylmercury dimethyldithiocarbamate Mate, phenylmercuric nitrate, phosdifen, prothiocarb, prothiocarb hydrochloride, Pyracarbollide, pyridinitrile, pyroxchlor, pyroxyflur, quinacetol, sulfate Quinacetonitrile, quinazamide, quinconazole, rabenzazole, salicylanilide, SS F-109, Sultropene, Tecolum, Thiazifluor, Thiofen, Thiochlorfe nitriloside, thiophanate, thioquinox, tioximide, triamiphos, triarimol , triazbutyl, triclamid, urvacid, zaliramide, and any combination thereof The compound is selected from the group consisting of:

[0414] In some embodiments, the pesticide is an insecticide. In some embodiments, the pesticide is an acaricide. In some embodiments, the insecticide is a nematicide. The killing agent is a herbicide.

[0415] Examples of insecticides and acaricides include, but are not limited to, abamectin (abamectin amectin), pyriproxyfen, acetamiprid, bifenthrin, cyfluthrin, pymetrozine, novaluron, ethiprole, fipronil, and lambda-cyhalothrin.

[0416] Examples of nematicides include, but are not limited to, fluensulfone. Some examples include:

[0417] The combination, mixture or composition may be applied to the fungus or to the location where it is present. Application can be by conventional ground sprayers, granule applicators, or by spraying with a granule sprayer. This can be accomplished by the use of ion exchangers, and by other conventional means known to those skilled in the art. Cut.

[0418] Each embodiment disclosed in this specification is applicable to each other disclosed embodiment. Accordingly, all combinations of the various elements described herein are contemplated herein. In addition, elements recited in combination embodiments may be combined in any combination as described herein. and vice versa. .

[0419] Synergy calculations Synergy occurs whenever the action of a combination of active ingredients is greater than the sum of the actions of the individual components. There is a positive effect.

[0420] In the field of agriculture, the term "synergy" originated in the journal Weeds, 1967, 15, p. 20-22. The title of the paper is "Calculation of the synergistic and antagonistic responses of he As defined by Colby SR in the article "rbicide combinations" It is often understood that the expected effect of a given combination of two active ingredients is as follows: can be calculated as:

[0421]

number

[0422] While the subject matter has been shown and described with reference to preferred embodiments thereof, many alternatives are possible. Substitutions, changes, and modifications may be made without departing from the spirit and scope of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the above-mentioned embodiments, and therefore, all such modifications and variations are within the spirit and broad scope of the appended claims. It is intended to embrace all such alternatives, modifications and variances.

[0423] All publications, patents, and patent applications mentioned herein are hereby incorporated by reference as if each was individually incorporated by reference. Each publication, patent, or patent application is specifically and individually incorporated by reference herein. No. 6,393,411, filed on Oct. 13, 2003, and which are incorporated herein by reference in their entireties to the same extent as if set forth herein. will be done.

[0424] The following examples illustrate the practice of the present subject matter in some embodiments, but are not intended to limit the scope of the present subject matter. Other embodiments are contemplated by consideration of the specification and examples. It will be understood by those skilled in the art that the present specification, including the examples, is intended to provide a general understanding of the present subject matter. It is intended that they be considered illustrative only, without being limiting in scope or spirit.

[0425] Experimental Section material and method The compounds of formula I are disclosed in WO 2015 / 103144 and WO 2015 / 103145. The compositions can be prepared as described in US Pat. No. 5,314,522. Pydiflumetofen (ADEPYDIN®, Synge nta)-0.05% in Tween 80 Fluindapyr - 0.05% in Tween 80 Mefentrifluconazole - 0.05 in Tween 80 % Fenpicoxamid - 0.05% in Tween 80 Inpyrfluxam - 0.05% in Tween 80 Isofetamide - 0.05% in Tween 80

[0426] The compound of formula I and fluindapyr, pydiflumetofen en), mefentrifluconazole, fenpicoxamide picoxamid, inpyrfluxam and isofetamide and a fungicide selected from the group consisting of: Winter wheat plants, cultivar Alixan (Limagrain), are treated.

[0427] The compound of formula I and the fungicide (A) were mixed in different ratios and weight ratios using a hand-held sprayer. The test conditions were as follows: Use iterations (pots).

[0428] Cut off the first leaf fragment and transfer it to a Petri dish containing adapted plain agar (1 Petri dish The segments contained Z. tritici strain Mg Tri-R6. Inoculate with a calibrated pycnospore suspension.

[0429] After inoculation, the petri dishes were placed in a climate chamber (temperature 20°C during the day / 17°C at night, 16 hours light / 8 hours dark). The plants are incubated at 100°C for 24 hours at a dark day length and controlled relative humidity. Disease severity is assessed by the length of time the leaf segments become necrotic. This is done 21 days post-inoculation (dpi) and 28 dpi by measuring the length of the The intensity of infection is determined as a percentage of the total length of the leaf section.

[0430] Based on the area under the disease progression curve (AUDPC), a quantitative measure of disease severity over time, Calculate the effectiveness of the AUDPC, which is the most commonly used method to estimate the AUDPC. Multiplying the average disease intensity between each pair of adjacent time points by the corresponding time interval The trapezoidal algorithm using and is performed for each time interval.

[0431] Bactericidal efficacy was determined from AUDPC values ​​and expressed as a percentage of the untreated control.

[0432] [Example 1] Synergy of mixtures of the compound of formula I with mefentrifluconazole test The compounds of formula I and mefentrifluconazole are shown in the table below. The mixture was dispersed according to 1.

[0433] [Table 1]

[0434] The compound of formula I and mefentrifluconazole were Applied by a sprayer calibrated to 2 bar to deliver the equivalent of 200 L / ha ( Three replicates (pots) of six wheat plants each were used for each treatment group.

[0435] A fragment of the first leaf was cut and transferred to a Petri dish containing adapted plain agar (one Petri dish (6 leaf segments per dish). The segments contained Z. tritici strain Mg Tri-R6. The samples were inoculated with a calibrated pycnospore suspension of 100 ml.

[0436] After inoculation, the petri dishes were incubated at 20°C day / 17°C night with a 16-hour light / 8-hour dark cycle. The plants were incubated in a climate chamber with a photoperiod of 100 s and 100 s and controlled relative humidity. Disease assessment was performed using leaf fragments. The length of necrosis was measured at 21 days post-inoculation (dpi) and 28 dpi. The intensity of infection was then determined as a percentage of the total length of the leaf sections.

[0437] Based on the area under the disease progression curve (AUDPC), a quantitative measure of disease severity over time, The efficacy of the 100% 15 ... Multiplying the average disease intensity between each pair of adjacent time points by the corresponding time interval A trapezoidal algorithm using and was performed for each time interval.

[0438] Bactericidal efficacy was determined from AUDPC values ​​and expressed as a percentage of the untreated control.

[0439] The results are shown in Table 2 and Figure 1.

[0440] [Table 2]

[0441] [Example 2] Synergy testing of mixtures of compounds of formula I with fenpicoxamid The compounds of formula I and fenpicoxamid were administered according to Table 3 below. Used.

[0442] [Table 3]

[0443] The compound of formula I and fenpicoxamid were sprayed by handheld sprayer. , calibrated to 2 bar to deliver the equivalent of 200 L / ha. Three replicates (pots) of wheat plants were used for each treatment group.

[0444] A fragment of the first leaf was cut and transferred to a Petri dish containing adapted plain agar (one Petri dish (6 leaf segments per dish). The segments contained Z. tritici strain Mg Tri-R6. The samples were inoculated with a calibrated pycnospore suspension of 100 ml.

[0445] After inoculation, the petri dishes were incubated at 20°C day / 17°C night with a 16-hour light / 8-hour dark cycle. The plants were incubated in a climate chamber with a photoperiod of 100 s and 100 s and controlled relative humidity. Disease assessment was performed using leaf fragments. The length of necrosis was measured at 21 days post-inoculation (dpi) and 28 dpi. The intensity of infection was then determined as a percentage of the total length of the leaf sections.

[0446] Based on the area under the disease progression curve (AUDPC), a quantitative measure of disease severity over time, The efficacy of the 100% 15 ... Multiplying the average disease intensity between each pair of adjacent time points by the corresponding time interval A trapezoidal algorithm using and was performed for each time interval.

[0447] Bactericidal efficacy was determined from AUDPC values ​​and expressed as a percentage of the untreated control.

[0448] The results are shown in Table 4 and FIG.

[0449] [Table 4]

[0450] [Example 3] Synergy Testing of Mixtures of Compounds of Formula I with Fluindapyr The compounds of formula I and fluindapyr were applied according to Table 5 below. .

[0451] [Table 5]

[0452] The compound of formula I and fluindapyr were administered by handheld aerosol at 20 The application was calibrated to 2 bar to deliver the equivalent of 1.0 L / ha. Three replicates (pots) of cedar plants were used for each treatment group.

[0453] A fragment of the first leaf was cut and transferred to a Petri dish containing adapted plain agar (one Petri dish (6 leaf segments per dish). The segments contained Z. tritici strain Mg Tri-R6. The samples were inoculated with a calibrated pycnospore suspension of 100 ml.

[0454] After inoculation, the petri dishes were incubated at 20°C day / 17°C night with a 16-hour light / 8-hour dark cycle. The plants were incubated in a climate chamber with a photoperiod of 100 s and 100 s and controlled relative humidity. Disease assessment was performed using leaf fragments. The length of necrosis was measured at 21 days post-inoculation (dpi) and 28 dpi. The intensity of infection was then determined as a percentage of the total length of the leaf sections.

[0455] Based on the area under the disease progression curve (AUDPC), a quantitative measure of disease severity over time, The efficacy of the 100% 15 ... Multiplying the average disease intensity between each pair of adjacent time points by the corresponding time interval A trapezoidal algorithm using and was performed for each time interval.

[0456] Bactericidal efficacy was determined from AUDPC values ​​and expressed as a percentage of the untreated control.

[0457] The results are shown in Table 6 and FIG.

[0458] [Table 6]

[0459] [Example 4] Synergy testing of mixtures of compounds of formula I with pydiflumetofen Winter wheat plants, cultivar Alixan (Limagr) at BBCH 12 growth stage ain) in several ratios of the compound of formula I and pydiflumetofen. A handheld mix calibrated to 2 bar to deliver the equivalent of 200 L / ha with the mix at The compound of formula I was applied at 5 g ai / ha. Metofen (pydiflumetofen) at 0.00032 to 0.0016 and 0.008 ga i. / ha. Three replicates (pots) of six wheat plants each were tested. was used in the condition group.

[0460] After treatment, the wheat plants were allowed to dry for 1 hour at room temperature and then incubated at 24°C day / 18°C night. , in a climate chamber with a photoperiod of 16 h light / 8 h dark and a relative humidity of 65%. Fragments of the first leaves were cut and transferred to petri dishes containing adapted plain agar (one The leaves were then mixed with Z. tritici strain MgTrp and 6 leaf fragments per Petri dish. A calibrated pycnospore suspension of i-R6 was inoculated.

[0461] After inoculation, the petri dishes were incubated at 20°C day / 17°C night with a 16-hour light / 8-hour dark cycle. The plants were cultured in a climate chamber with a photoperiod of 100 s and controlled relative humidity.

[0462] Disease assessment was performed 21 days postinoculation (dpi) by measuring the length of necrotic leaf segments. and 28 dpi. The intensity of infection was then determined as a percentage of the total length of the leaf segments. did.

[0463] Based on the area under the disease progression curve (AUDPC), a quantitative measure of disease severity over time, The efficacy of the 100% 15 ... Multiplying the average disease intensity between each pair of adjacent time points by the corresponding time interval A trapezoidal algorithm using and was performed for each time interval.

[0464] Bactericidal efficacy was determined from AUDPC values ​​and expressed as a percentage of the untreated control.

[0465] The results are shown in Table 7 and FIG.

[0466] [Table 7]

[0467] [Example 5] Synergy study of mixtures of the compound of formula I with inpyrfluxam Winter wheat plants, cultivar Alixan (Limagr) at BBCH 12 growth stage ain) in several ratios of the compound of formula I and inpyrfluxam A hand-held fertilizer calibrated to 2 bar to deliver the equivalent of 200 L / ha with a mixture of Three replicates (pots) of six wheat plants each were tested. Used for condition groups.

[0468] Cut off the first leaf fragment and transfer it to a Petri dish containing adapted plain agar (1 Petri dish The segments contained Z. tritici strain Mg Tri-R6. Inoculate with a calibrated pycnospore suspension.

[0469] After inoculation, the petri dishes were incubated at 20°C day / 17°C night with a 16-hour light / 8-hour dark cycle. The plants are incubated in a climate chamber with a photoperiod of 100 s and a controlled relative humidity. Disease assessment is performed on leaf fragments. The length of necrosis was measured at 21 days post-inoculation (dpi) and 28 dpi. The intensity of infection is then determined as a percentage of the total length of the leaf sections.

[0470] Based on the area under the disease progression curve (AUDPC), a quantitative measure of disease severity over time, Calculate the effectiveness of the AUDPC, which is the most commonly used method to estimate the AUDPC. Multiplying the average disease intensity between each pair of adjacent time points by the corresponding time interval The trapezoidal algorithm using and is performed for each time interval.

[0471] Bactericidal efficacy was determined from AUDPC values ​​and expressed as a percentage of the untreated control.

[0472] The results show that the mixture of the compound of formula I with inpyrfluxam in two ways showed synergistic effects against the wheat pathogen Z. tritici strain MgTri-R6. vinegar.

[0473] [Example 6] Synergy studies of mixtures of compounds of formula I with isofetamide Winter wheat plants, cultivar Alixan (Limagr) at BBCH 12 growth stage ain) was mixed with the compound of formula I and isofetamide in several ratios. A handheld sprayer calibrated to 2 bar to deliver the equivalent of 200 L / ha was used. Three replicates (pots) of six wheat plants each were tested for each condition group. Used for.

[0474] Cut off the first leaf fragment and transfer it to a Petri dish containing adapted plain agar (1 Petri dish The segments contained Z. tritici strain Mg Tri-R6. Inoculate with a calibrated pycnospore suspension.

[0475] After inoculation, the petri dishes were incubated at 20°C day / 17°C night with a 16-hour light / 8-hour dark cycle. The plants are incubated in a climate chamber with a photoperiod of 100 s and a controlled relative humidity. Disease assessment is performed on leaf fragments. The length of necrosis was measured at 21 days post-inoculation (dpi) and 28 dpi. The intensity of infection is then determined as a percentage of the total length of the leaf sections.

[0476] Based on the area under the disease progression curve (AUDPC), a quantitative measure of disease severity over time, Calculate the effectiveness of the AUDPC, which is the most commonly used method to estimate the AUDPC. Multiplying the average disease intensity between each pair of adjacent time points by the corresponding time interval The trapezoidal algorithm using and is performed for each time interval.

[0477] Bactericidal efficacy was determined from AUDPC values ​​and expressed as a percentage of the untreated control.

[0478] The results show that the mixture of the compound of formula I and isofetamide in two ways The results show that Mg has a synergistic effect against Z. tritici strain Mg Tri-R6.

[0479] conclusion As shown, a compound of formula I and a fungicide (A) (wherein the fungicide (A) is a fluviral Fluindapyr, pydiflumetofen, mefentriflucona Mefentrifluconazole, fenpicoxamid, impilflu Inpyrfluxam and isofetamide ) demonstrates strong synergistic effects.

Claims

1. (i) an amount of a compound of formula I; 【Chemistry 1】 (ii) a predetermined amount of fluindapyr, pydiflumetofen, ofen, mefentrifluconazole, inpirfluxam npyrfluxam), isofetamide, and Qi inhibitors. At least one fungicide (A) A disinfectant combination comprising:

2. a) the combination is used in the treatment of plants or the locus in which the plants are present against fungal infections , more effective than each fungicide applied alone at the same amount; b) the amount of the compound of formula I and the amount of the fungicide (A) are applied together. In some cases, each fungicide may be used alone to treat plants or plant loci against fungal infections. and / or c) The amount of the compound of formula I used is less than the amount of the compound of formula I when the compound of formula I is used alone. The amount of the fungicide (A) used is less than the fungicidal effective amount, and / or the fungicide (A) is used in an amount less than the fungicidal effective amount. less than the germicidal effective amount of the germicide (A) when used; 2. The combination of claim 1.

3. The Qi inhibitor is selected from the group consisting of thiazoimidazole, sulfamoyltriazole, and picolinyltriazole.

3. The combination according to claim 1 or 2, wherein said compound is an amide.

4. The cyazoimidazole is cyazofamid or the sulfamoyltriazole is is amisulbrom or the picolinamide is fenpicoxamide 4. The combination of claim 3, wherein said compound is amid.

5. 10. The composition according to claim 1, wherein the weight ratio of the compound of formula I to the fungicide (A) is about 400:1 to 1:

400. A combination according to any one of claims 1 to 4.

6. 6. The composition according to claim 1, wherein the weight ratio of the compound of formula I to the fungicide (A) is about 10:1 to 1:

10.

2. The combination according to claim 1 .

7. 10. The method of claim 1, wherein the composition has a synergistic effect in treating plants or the locus in which the plants are present against fungal infection. A combination according to any one of claims 1 to 6.

8. 8. The composition according to claim 1, having a synergistic therapeutic effect and / or a synergistic protective effect. The combination according to claim 1.

9. At least one insecticide, at least one stabilizing surfactant, and / or at least 9. The composition according to claim 1, further comprising at least one botanically acceptable adjuvant. A combination according to claim 1.

10. A mixture comprising a combination according to any one of claims 1 to 9.

11. 11. The mixture of claim 10, wherein the mixture is a tank mix.

12. A composition comprising a combination according to any one of claims 1 to 9.

13. a) the composition comprises from about 0.1% to about 9% by weight of a compound of formula I based on the total weight of the composition; and / or b) the composition contains a fungicide (A) in an amount of about 0.1% to 9% by weight based on the total weight of the composition; 0% by weight The composition of claim 12.

14. 14. The composition according to claim 12 or 13, further comprising a botanically acceptable carrier. Composition of.

15. 1. A method of treating a plant or a locus in which a plant is present against a fungal infection, comprising: (i) an amount of a compound of formula I, 【Chemistry 2】 And (ii) a predetermined amount of fluindapyr, pydiflumetofen, ofen, mefentrifluconazole, inpirfluxam npyrfluxam), isofetamide, and Qi inhibitors. At least one fungicide (A) applying to said plant or to a location where said plant is present, thereby causing said plant or to a location where said plant is present. and treating the affected area for a fungal infection.

16. A method of treating a plant or the locus in which the plant is located against a fungal infection comprising the steps of: The combination, mixture or composition according to any one of claims 1 to 14 is administered to the plant or and applying the composition to the locus where the plant is present, thereby rendering said plant or the locus where the plant is present susceptible to fungal infection. The method includes treating against the stain.

17. a) the method comprises the steps of: treating a plant or a locus in which a plant is present against a fungal infection, more effective than the fungicide applied alone at the same dose; b) the amount of the compound of formula I and the amount of the fungicide (A) are applied together. In some cases, each fungicide may be used alone to treat plants or plant loci against fungal infections. is more effective than the equivalent amount applied at c) The amount of the compound of formula I used is less than the amount of the compound of formula I when the compound of formula I is used alone. The amount of the fungicide (A) used is less than the fungicidal effective amount, and / or the fungicide (A) is used in an amount less than the fungicidal effective amount. less than the germicidal effective amount of the germicide (A) when used; d) the method is effective to control fungal infection of the plant or the locus in which the plant is present. and / or e) the method is effective in protecting the plant or the locus in which the plant is located against fungal infection. Is valid, 17. The method according to claim 15 or 16.

18. a) controlling fungal infection is a fungal disease that infects the plant or the locus in which the plant is present and controlling plant or soil diseases caused by phytopathogenic fungi. controlling fungal infestation of said plant or the locus in which said plant resides; or to reduce fungal infections in the locus where the plant is located and / or to prevent the growth of plant pathogens. and / or treating plant or soil diseases caused by b) protecting said plant or the locus in which said plant is present against fungal infection, or protecting the plant or the locus where the plant is located against fungal infestation, to protect the plant or the locus in which it is located from fungal diseases and / or This includes preventing fungal infections in areas where 20. The method of claim 17.

19. a) a compound of formula I and a fungicide (A) are applied to the propagation material of said plant; b) a compound of formula I and a fungicide (A) are applied to the seeds and / or seedlings of said plants. R, c) the method comprises the protective application of a compound of formula I and a fungicide (A), d) the method comprises the therapeutic application of a compound of formula I and a fungicide (A), e) the compound of formula I and the fungicide (A) are applied simultaneously or contemporaneously; f) the compound of formula I and the fungicide (A) are applied separately or together; g) the method is effective in reducing leaf necrosis; h) the compound of formula I is applied in an amount of from 1 g / ha to 500 g / ha, and / or i) the fungicide (A) is applied in an amount of from 0.1 g / ha to 500 g / ha; The method according to any one of claims 15 to 18.

20. 20. The method according to any one of claims 15 to 19, wherein the compound of formula I is applied in an amount of from 5 g / ha to 10 g / ha. The method according to any one of claims 1 to 5.

21. a) Fluindapyr is applied in the range of 0.1 g / ha to 150 g / ha. To be done, b) pydiflumetofen, 0.0001 g / ha to 150 g / h Applied within the scope of a c) Mefentrifluconazole at 0.1 g / ha to 15 g / ha 0 g / ha. d) a Qi inhibitor, preferably fenpicoxamid, at 0.1 g / ha Applied in the range of 150 g / ha to 150 g / ha. e) Inpyrfluxam in the range of 0.1 g / ha to 150 g / ha applied in, or f) Isofetamide is applied in the range of 0.1 g / ha to 150 g / ha. To be done, The method according to any one of claims 15 to 20.

22. A method for controlling a plant disease caused by a plant pathogenic fungus, comprising: The present invention relates to a method for the treatment of a pulmonary artery disease, comprising administering to a patient a therapeutically effective amount of a combination, mixture or composition according to any one of claims 1 to 14, with the composition, thereby controlling said plant disease.

23. A method for controlling fungal infestation of plants, seeds or seedlings comprising the step of: The combination, composition or mixture according to claim 1 is applied to the plant, seed, seedling and / or applied to the location where the plant is present, thereby controlling fungal infestation of said plant, seed or seedling. The method includes:

24. A method for controlling fungal infestation of plants, seeds or seedlings comprising the step of: The combination, mixture or composition according to claim 1 is administered to said plants, seeds, seedlings and / or applied to the location where the plant is present, thereby controlling fungal infestation of said plant, seed or seedling. The method includes:

25. 1. A method of treating a plant, seed or seedling to produce a plant resistant to fungal infestation, comprising: The combination, mixture or composition according to any one of claims 1 to 14 is applied to the plant, Seeds adapted to produce said plants, seedlings adapted to produce said plants, and is applied to the locus where said plants are present, thereby producing plants that are resistant to fungal infestation. The method of claim 1,

26. A method for protecting plants from fungal infestation, comprising the step of: The combination, mixture or composition is applied to the plant, the locus where the plant is located, or to the plant. by applying to seeds or seedlings adapted to produce fungal infections, thereby rendering said plants free of fungal infestation.

5. A method according to claim 1 , comprising:

27. A seed adapted to produce a plant resistant to fungal infestation, A seedling adapted to produce a plant or the locus in which said plant is present is adapted to produce a plant according to any one of claims 1 to 14. A plant which has been treated with the combination, mixture or composition described in any one of claims 1 to 5.

28. A plant seed or seedling adapted to produce a plant resistant to fungal infestation, comprising: The plant seed or seedling is a combination, mixture or plant extract according to any one of claims 1 to 14. or a plant seed or seedling which has been treated with the composition.

29. A method for controlling fungal infestation in plants, comprising the step of: The combination, mixture or composition may be applied to soil, plants, roots, leaves, seeds, the locus of fungus, and and / or to the location where fungal infestation is to be prevented, thereby preventing the infestation of said plants. controlling the invasion.

30. A method for controlling fungal diseases of plants and / or soil comprising the step of: The combination, mixture or composition according to claim 1 is administered to soil, plants, roots, leaves, seeds, fungal and / or where fungal infestation is to be prevented, thereby 23. The method of claim 22, further comprising controlling a fungal disease of the plant and / or soil.

31. A method for controlling a plant disease caused by a plant pathogenic fungus, comprising the steps of: The propagation material, or the locus in which the plant is present, is treated with (i) a predetermined amount of a compound of formula I, 【Chemistry 3】 And (ii) a predetermined amount of fluindapyr, pydiflumetofen, ofen, mefentrifluconazole, inpirfluxam npyrfluxam), isofetamide, and Qi inhibitors. At least one fungicide (A) thereby controlling said plant disease.

32. A method for controlling fungal infestation in a plant, seed or seedling, comprising the steps of: or to the locus where the plant is present, (i) a predetermined amount of a compound of formula I, 【Chemistry 4】 And (ii) a predetermined amount of fluindapyr, pydiflumetofen, ofen, mefentrifluconazole, inpirfluxam npyrfluxam), isofetamide, and Qi inhibitors. At least one fungicide (A) thereby controlling fungal infestation on said plant, seed or seedling. Law.

33. A method for protecting a plant, seed or seedling from fungal infestation, comprising the steps of: and / or to the locus where said plant is located, (i) a predetermined amount of a compound of formula I, 【Chemistry 5】 And (ii) a predetermined amount of fluindapyr, pydiflumetofen, ofen, mefentrifluconazole, inpirfluxam npyrfluxam), isofetamide, and Qi inhibitors. At least one fungicide (A) thereby protecting said plant, seed or seedling from fungal infection. Law.

34. A method for treating plants or the locus where plants are present against fungal infections, comprising the steps of: Use of a combination, mixture or composition according to any one of the claims.

35. For use in treating plants or the locus in which the plants are present against fungal infections. A combination, mixture or composition according to any one of claims 1 to 14.

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