Liquid medicine filling device

Abstract

To provide a liquid medicine filling device that includes a filler capable of improving movement stability of a stopper within a cylindrical body during adjustment of a filling amount of a liquid medicine to a liquid medicine reservoir of a cartridge.SOLUTION: A liquid medicine filling device according to the present disclosure includes: a cartridge which has a syringe-type liquid medicine reservoir; and a filler into which the cartridge can be mounted and which is capable of filling the liquid medicine into the liquid medicine reservoir of the cartridge. The liquid medicine reservoir of the cartridge includes: a cylindrical body that defines a storage space that can accommodate the liquid medicine; and a stopper that is movable along an axial direction of the cylindrical body within the cylindrical body. The filler includes: a receiving recess into which the cartridge can be inserted along the axial direction of the cylindrical body; and a support body that directly contacts the stopper of the cartridge inserted into the receiving recess and supports the stopper.SELECTED DRAWING: Figure 13B

Description

[Technical field]

[0001] The present disclosure relates to a drug solution filling device. [Background technology]

[0002] In recent years, a treatment method has been performed in which a medicinal liquid is continuously administered into a patient's body by subcutaneous injection, intravenous injection, or the like. For example, a treatment method for a diabetic patient is known in which a small amount of insulin is continuously injected into the patient's body. In this treatment method, an insulin pump is used as a portable medicinal liquid administration device that can be fixed to the patient's body or clothing and carried around in order to continuously administer insulin to the patient. As this type of medicinal liquid administration device, a medicinal liquid administration device is known in which a cartridge as a disposable part filled with medicinal liquid such as insulin is attached to a reusable part, and pressure is applied to the medicinal liquid by a plunger to administer the medicinal liquid into the patient's body. Such a medicinal liquid administration device is described, for example, in Patent Document 1.

[0003] Patent Document 1 also describes a liquid medicine filling machine as a filler used to fill a liquid medicine reservoir of a cartridge with a liquid medicine from a liquid medicine container that contains the liquid medicine. The liquid medicine filling machine of Patent Document 1 is equipped with a filling amount adjustment mechanism. In the filling amount adjustment mechanism of Patent Document 1, a movable member connected to a feed screw portion moves to move an engagement piece that engages with a shaft portion of a pusher member of the cartridge. In other words, in the filling amount adjustment mechanism of Patent Document 1, a stopper connected to the shaft portion can be moved within a storage body as a cylinder via the shaft portion of the cartridge by moving the movable member. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Patent No. 6978428 Summary of the Invention [Problem to be solved by the invention]

[0005] The filling amount adjustment mechanism of the liquid medicine filling machine described in Patent Document 1 still has room for improvement in terms of the stability of the movement of the stopper inside the cylinder.

[0006] The present disclosure aims to provide a liquid medicine filling device including a filling device that can improve the movement stability of a stopper within a cylindrical body when adjusting the amount of liquid medicine filled into a liquid medicine reservoir of a cartridge. [Means for solving the problem]

[0007] A drug solution filling device according to a first aspect of the present disclosure includes: (1) a cartridge including a syringe-type drug reservoir; a filler capable of loading the cartridge and filling a liquid medicine reservoir of the cartridge with a liquid medicine; The drug reservoir of the cartridge includes: A cylindrical body defining a storage space capable of storing the medicinal liquid; a stopper movable along an axial direction of the cylindrical body inside the cylindrical body, The filling device includes: a receiving recess into which the cartridge can be inserted along the axial direction of the cylindrical body; a support body that directly contacts the stopper of the cartridge inserted into the accommodating recess and supports the stopper.

[0008] As one embodiment of the present disclosure, a drug solution filling device includes: (2) The filling device includes: a holder that holds the support body so as to be movable in the axial direction; The drug solution filling device according to claim 1, further comprising an adjustment body capable of adjusting the axial position of the support body.

[0009] As one embodiment of the present disclosure, a drug solution filling device includes: (3) The adjustment body includes a shaft portion extending in the axial direction and having a male thread portion formed on an outer surface thereof, The drug solution filling device according to (2) above, wherein the support body is provided with a thread groove portion that engages with the male thread portion of the shaft portion.

[0010] As one embodiment of the present disclosure, a drug solution filling device includes: (4) In the liquid medicine filling device according to (3) above, the holding body rotatably holds the shaft portion of the adjustment body.

[0011] As one embodiment of the present disclosure, a drug solution filling device includes: (5) the filler includes a lock mechanism that engages with the cartridge inserted into the accommodating recess and restricts movement of the cartridge in the axial direction; The locking mechanism includes: a swinging body that is swingably held by the holding body and that is swingable between a locked position where it engages with the cartridge and an unlocked position where it is separated from the cartridge; a biasing member that biases the rocking body to the lock position; a movable body that is held by the holding body so as to be movable in the axial direction, and that is movable in the axial direction between a support position that supports the rocker at the unlocked position against the biasing force of the biasing member, and a non-support position that is separated from the rocker and does not support the rocker, This is a drug solution filling device described in any one of (2) to (4) above, in which when the cartridge is inserted into the accommodating recess, the moving body is pressed and moved from the supporting position to the non-supporting position, whereby the oscillating body oscillates from the unlocked position to the locked position due to the biasing force of the biasing member and engages with the cartridge.

[0012] As one embodiment of the present disclosure, a drug solution filling device includes: (6) the cartridge comprises a cartridge housing that holds the drug solution reservoir; In the drug solution filling device according to (5) above, the rocking body of the locking mechanism is provided with a claw portion that engages with the cartridge housing.

[0013] As one embodiment of the present disclosure, a drug solution filling device includes: (7) the cartridge includes a shaft portion protruding from the stopper, The filling device is attached to the rocking body of the locking mechanism, and is provided with a shaft engaging member that rocks following the rocking motion of the rocking body and engages with the shaft portion when the rocking body is at the lock position; The drug solution filling device is described in (5) or (6) above, wherein the shaft engaging member is attached so as to be movable relative to the oscillating body in the axial direction, and is movable in the axial direction in response to the axial movement of the support body.

[0014] As one embodiment of the present disclosure, a drug solution filling device includes: (8) The drug solution filling device according to any one of (2) to (7) above, wherein the accommodating recess is formed in the holder. Effect of the Invention

[0015] According to the present disclosure, it is possible to provide a liquid medicine filling device including a filling device capable of improving the movement stability of a stopper within a cylindrical body when adjusting the amount of liquid medicine filled into a liquid medicine reservoir of a cartridge. [Brief description of the drawings]

[0016] [Figure 1] 1 is a diagram showing a drug solution filling device according to an embodiment of the present disclosure; [Diagram 2] 1 is an exploded perspective view showing an example of a drug solution administration device including a cartridge. [Diagram 3] FIG. 2 is a plan view of the cartridge as viewed from above. [Figure 4]FIG. [Diagram 5] FIG. [Figure 6] FIG. 13 is a diagram showing how an adapter is attached to a cartridge. [Figure 7] FIG. 2 shows a cartridge with an adapter and a filler. [Figure 8] 13 is a diagram showing a state in which the adaptor-attached cartridge is accommodated in an accommodating recess. FIG. [Figure 9] 9 is a diagram showing a state in which the liquid medicine container is connected to a container connecting portion of an adapter, following the state shown in FIG. 8. [Figure 10A] 4A to 4C are diagrams for explaining the principle by which a liquid medicine from a liquid medicine container is filled into a liquid medicine reservoir of a cartridge. [Figure 10B] 4A to 4C are diagrams for explaining the principle by which a liquid medicine from a liquid medicine container is filled into a liquid medicine reservoir of a cartridge. [Figure 11] FIG. [Figure 12] This is an oblique view showing the adjustment mechanism extracted from the main body of the filling device. [Figure 13A] 13 is a diagram showing a non-contact state between a stopper of a cartridge and a support body of a filling device before the cartridge is inserted into an accommodating recess of the filling device. FIG. [Figure 13B] 13 is a diagram showing a state in which the cartridge is inserted into the receiving recess of the filling device and the stopper of the cartridge is in contact with the support body of the filling device. FIG. [Figure 14A] 13 is a diagram showing a non-contact state between a stopper of a cartridge and a support body of a filling device before the cartridge is inserted into an accommodating recess of the filling device. FIG. [Figure 14B] 13 is a diagram showing a state in which the cartridge is inserted into the receiving recess of the filling device and the stopper of the cartridge is in contact with the support body of the filling device. FIG. [Figure 15] 13C is a rear view of the support body and the adjuster shown in FIG. 13A and FIG. 13B. [Figure 16] This is an oblique view showing the locking mechanism and shaft engagement member extracted from the main body of the filling device. [Figure 17A] 13A and 13B are diagrams showing the rocking action of the rocking body, and show a state in which the rocking body is in a locked position. [Figure 17B] 13 is a diagram showing the rocking action of the rocking body, and is a diagram showing a state in which the rocking body is in an unlocked position. FIG. [Figure 18A] FIG. 13 shows a state in which the cartridge is being inserted into the receiving recess of the filler. [Figure 18B] 18B is a diagram showing a state in which the cartridge is further inserted into the receiving recess from the state shown in FIG. 18A and pressed by the cartridge, causing the movable body to move in the insertion direction. [Figure 18C] 18C is a diagram showing a state in which the rocking body has rocked from the state shown in FIG. 18B and moved from the unlocked position to the locked position. [Figure 19] This is an oblique view showing the support body, the holder, the adjustment body, and the shaft engagement member extracted from the main body of the filling device. [Figure 20] 1 is a perspective view showing the inside of a storage recess of a filling device. FIG. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0017] Hereinafter, an embodiment of a drug solution filling device according to the present disclosure will be illustrated and described with reference to the drawings. In each drawing, the same components are denoted by the same reference numerals.

[0018] Fig. 1 is a diagram showing a liquid medicine filling device 100 as one embodiment of the liquid medicine filling device according to the present disclosure. As shown in Fig. 1, the liquid medicine filling device 100 includes a cartridge 2, a filler 3, and an adapter 4. As shown in Fig. 1, the adapter 4 includes an upper cover 4a and a lower cover 4b. Fig. 1 shows a state in which the liquid medicine filling device 100 is disassembled into the cartridge 2, the filler 3, the upper cover 4a of the adapter 4, and the lower cover 4b of the adapter 4. In Fig. 1, in addition to the liquid medicine filling device 100, a liquid medicine container 300 is also shown.

[0019] The cartridge 2 is provided with a syringe-type medicinal liquid reservoir 2a capable of storing a medicinal liquid. The medicinal liquid filling device 100 shown in FIG. 1 is used to fill the medicinal liquid reservoir 2a of the cartridge 2 with a medicinal liquid from a medicinal liquid container 300 such as a vial. The cartridge 2 in which the medicinal liquid reservoir 2a has been filled with the medicinal liquid by the medicinal liquid filling device 100 is removed from the filler 3 and the adapter 4, and used as a part of a medicinal liquid administration device. FIG. 2 is an exploded perspective view showing an example of a medicinal liquid administration device 10 including the cartridge 2. First, an overview of the medicinal liquid administration device 10 including the cartridge 2 will be described.

[0020] <Chemical solution administration device 10> As shown in FIG. 2, the drug solution administration device 10 includes a cradle 14 having an attachment part 12 that can be attached to the skin of a user such as a patient, and a drug solution administration device main body 16 that is detachably attached to the cradle 14. The drug solution administration device 10 is used in a state in which the attachment surface 12a of the attachment part 12 of the cradle 14 is attached to the skin of the user. The drug solution administration device main body 16 includes a cartridge 2 as a disposable disposable part and a reusable part 30. As described above, the cartridge 2 includes a syringe-type drug solution reservoir 2a. Specifically, the drug solution reservoir 2a includes a cylindrical body 36 that defines a storage space 36b that can store the drug solution, and a plunger 38. The drug solution administration device 10 is a portable insulin pump that can continuously or intermittently administer the drug solution filled in the storage space 36b in the cylindrical body 36 to a living body under the pressing action of the plunger 38.

[0021] For ease of explanation, in the following, in the medicinal liquid administration device 10, the axial direction parallel to the central axis O1 of the cylindrical body 36 will be simply referred to as the "axial direction A." Also, in the medicinal liquid administration device 10, the side of the adhesive surface 12a (i.e., the side facing the body surface when the medicinal liquid administration device 10 is in use) will be referred to as the "lower side," and the side opposite the adhesive surface 12a side will be referred to as the "upper side."

[0022] [Cradle 14] The cradle 14 comprises a substantially rectangular support plate 18 to the underside of which the attachment part 12 is fixed, and a locking wall 20 rising from the outer periphery of the support plate 18. A cannula mechanism 22 having a cannula that is placed in the living body by a puncture mechanism (not shown) is attached to the approximate center of the support plate 18.

[0023] [Medicine administration device body 16] 3 is a plan view of the cartridge 2 as viewed from above. The cartridge 2 includes a cartridge housing 32 in the shape of a flat box with an open upper side. The bottom surface of the cartridge housing 32 has a substantially rectangular shape in plan view corresponding to the support plate 18 of the cradle 14. More specifically, the cartridge housing 32 of this embodiment includes a base plate portion 32a and a side wall portion 32b rising upward from the outer periphery of the base plate portion 32a.

[0024] Fig. 4 is a plan view seen from below of cartridge 2. As shown in Fig. 4, a recess is formed on the lower surface of base plate portion 32a of cartridge housing 32 as accommodation portion 34 in which cannula mechanism 22 is accommodated when cartridge 2 is attached to cradle 14.

[0025] As shown in FIG. 3, the drug solution reservoir 2a of the cartridge 2 is held in the cartridge housing 32. The drug solution reservoir 2a includes a cylindrical body 36 and a plunger 38. The cylindrical body 36 and the plunger 38 are held on the cartridge housing 32 while being accommodated in the cartridge housing 32. More specifically, the cylindrical body 36 and the plunger 38 of this embodiment are held on the base plate portion 32a while a part of their lower sides is surrounded by the side wall portion 32b. The cylindrical body 36 and the plunger 38 may also be held on the side wall portion 32b while a part of their lower sides is surrounded by the side wall portion 32b. That is, the cylindrical body 36 and the plunger 38 may be held on at least one of the base plate portion 32a and the side wall portion 32b while a part of them is surrounded by the side wall portion 32b.

[0026] The cylinder 36 includes a cylinder body 39a extending cylindrically along the axial direction A, and a tip wall 39b connected to the tip of the cylinder body 39a. The tip wall 39b closes the tip side of the cylinder body 39a. The cylinder 36 defines a storage space 36b capable of storing a liquid medicine by the cylinder body 39a and the tip wall 39b. The cylinder 36 may be formed of, for example, a transparent resin material so that the inside can be seen from the outside. The tip wall 39b of the cylinder 36 is formed with a filling port 36a through which the liquid medicine can be filled into the storage space 36b from a liquid medicine container 300 (see FIG. 1). In addition, the tip wall 39b of the cylinder 36 is connected to a liquid medicine flow path 37. One end of the liquid medicine flow path 37 is connected to the storage space 36b. A connection port 37a is provided at the other end of the liquid medicine flow path 37 opposite to the one end connected to the storage space 36b. Although details will be described later, in this embodiment, the liquid medicine flow path 37 also serves as a liquid medicine outlet port for discharging the liquid medicine within the cylindrical body 36 toward the cannula mechanism 22.

[0027] The plunger 38 is movable in the axial direction A relative to the cylindrical body 36. The plunger 38 may be integrally molded from, for example, a resin material. More specifically, the plunger 38 includes a stopper 52 movable along the axial direction A inside the cylindrical body 36, and a shaft portion 54 protruding from the stopper. The stopper 52 is slidable along the axial direction A inside the cylindrical body 36 with respect to the inner surface of the cylindrical main body portion 39a. The shaft portion 54 is connected to the base end side of the stopper 52 and protrudes to the outside of the cylindrical main body portion 39a of the cylindrical body 36. The tip portion of the stopper 52 is substantially conical in shape, and the outer diameter decreases toward the tip. The drug solution reservoir 2a of this embodiment further includes a seal member 53 that forms a seal between the stopper 52 and the inner surface of the cylindrical main body portion 39a of the cylindrical body 36 along the outer periphery of the stopper 52 of the plunger 38. In this embodiment, the stopper 52 is integrally formed from the same resin material as the plunger 38 and is used in combination with the seal member 53, but this is not limited to the above. It is also possible to omit the seal member 53 by forming the stopper 52 itself from a material having sealing properties.

[0028] The plunger 38 of this embodiment includes two shaft portions 54 extending to the outside of the cylindrical body 36. The two shaft portions 54 of this embodiment are disposed apart from each other and extend approximately parallel to the axial direction A. Each shaft portion 54 is formed with a groove portion 54a into which a convex portion 250 (see FIG. 16, etc.) of a shaft engagement member 207 (see FIG. 16, etc.) of the filler 3 (see FIG. 1) can be fitted. The base end of each shaft portion 54 is provided with an abutment surface 64 and a protrusion (not shown) against which a nut portion 42 (described later) abuts.

[0029] 3, the cartridge 2 of this embodiment further includes a feed screw shaft 40 and a nut portion 42 in addition to the above-mentioned drug solution reservoir 2a. The feed screw shaft 40 is disposed coaxially with the plunger 38. The nut portion 42 is screwed onto the feed screw shaft 40. The feed screw shaft 40 and the nut portion 42 are also held by the cartridge housing 32.

[0030] The feed screw shaft 40 is rotationally driven by a drive unit 76 with its tip end journaled by a bearing 74 provided in the cartridge housing 32. The drive unit 76 includes a battery 78 as a power source, a motor 80 driven by the battery 78, a gear box (power transmission mechanism) 82 that reduces the speed of the rotational driving force of the motor 80 and transmits it, and a transmission shaft 88 to which a spur gear 86 that meshes with an output gear 84 of the gear box 82 is fixed and which is engaged with the feed screw shaft 40 so as to be rotatable together with the feed screw shaft 40.

[0031] Of the drive unit 76 of this embodiment, the battery 78 and the transmission shaft 88 are provided in the cartridge 2. Also, of the drive unit 76 of this embodiment, the motor 80 and the gear box 82 are provided in a lid body 90 (see FIG. 2) of the reuse part 30 (see FIG. 2). However, this configuration is not limited. The reuse part 30 may be configured to include, for example, the battery 78. The lid body 90 of the reuse part 30 of this embodiment is configured to be detachable from the cartridge housing 32 so as to close the upper opening of the cartridge housing 32.

[0032] The battery 78 has terminals 92 that are electrically connected to the motor 80 of the reuse part 30 when the cartridge 2 is attached to the reuse part 30. The transmission shaft 88 is supported by a pair of bearings 94 provided in the cartridge housing 32 in a state where it is disposed coaxially with the feed screw shaft 40.

[0033] The nut portion 42 may be integrally molded from, for example, a resin material. The nut portion 42 of this embodiment includes a rectangular plate-shaped nut portion body 102 and a slide portion 104 provided on the nut portion body 102. A screw hole 106 into which the feed screw shaft 40 screws is formed in the nut portion body 102. The screw hole 106 is located approximately in the center of the nut portion body 102. A reinforcing cover made of, for example, a metal material or the like may be attached to the outer surface of the nut portion body 102.

[0034] The slide portion 104 is slidable relative to a guide wall 114 that is provided on the cartridge housing 32 and extends along the axial direction A. This allows the nut portion 42 to move smoothly along the axial direction of the feed screw shaft 40 (the same direction as the axial direction A) under the rotation of the feed screw shaft 40.

[0035] Next, the operation of the above-mentioned medicinal solution administration device 10 will be described.

[0036] First, a user fills the liquid medicine reservoir 2a of the cartridge 2 of the liquid medicine administration device 10 with the liquid medicine. At this time, a liquid medicine filling device 100 shown in Fig. 1 is used. This will be described in detail later.

[0037] Next, the reuse part 30 is attached to the cartridge 2 filled with the liquid medicine by the liquid medicine filling device 100. This causes power from the battery 78 of the cartridge 2 to be supplied to the components of the reuse part 30. In addition, the output gear 84 of the gear box 82 of the reuse part 30 meshes with the spur gear 86 of the cartridge 2.

[0038] Next, the drug solution administration device main body 16 is primed. Specifically, the motor 80 is rotated by operating a remote control (not shown). Then, the rotational driving force of the motor 80 is transmitted to the feed screw shaft 40 via the gear box 82, the spur gear 86, and the transmission shaft 88, so that the feed screw shaft 40 rotates and the nut part 42 advances toward the plunger 38 while sliding on the guide wall 114. Then, the nut part 42 contacts the base end face and the protrusion as the abutment surface 64 of the shaft part 54 of the plunger 38, and the protrusion is locked in the hole of the nut part main body 102. As a result, the plunger 38 is locked to the nut part 42, and the nut part 42 is in a use position where it can press the plunger 38 toward the tip side in the axial direction A.

[0039] Thereafter, the nut portion 42 is further advanced, the liquid medicine inside the cylindrical body 36 is pressed against the plunger 38, and the liquid medicine flow path 37 is filled with the liquid medicine, completing the priming.

[0040] Next, the user attaches the adhesive surface 12a of the attachment part 12 to a predetermined position on the skin, and uses the puncture mechanism to place the cannula of the cannula mechanism 22 of the cradle 14 inside the living body. Next, the user attaches the medical solution administration device main body 16 to the cradle 14. At this time, the connection port 37a of the medical solution flow path 37 of the medical solution administration device main body 16 is connected to the cannula mechanism 22 of the cradle 14. Then, by controlling the rotation of the motor 80, the medical solution in the cylinder 36 is discharged from the medical solution flow path 37, which also serves as a medical solution outlet, and is continuously or intermittently administered into the user's living body through the cannula of the cannula mechanism 22.

[0041] <Chemical solution filling device 100> Next, a detailed description will be given of the medicinal liquid filling device 100 shown in Fig. 1. As described above, the medicinal liquid filling device 100 is used to fill the cartridge 2 of the medicinal liquid administration device 10 with medicinal liquid.

[0042] Fig. 5 is a perspective view showing the adapter 4. As shown in Fig. 5, the upper cover 4a and the lower cover 4b of the adapter 4 can be attached to each other. Fig. 6 is a diagram showing a state in which the adapter 4 is attached to the cartridge 2. As shown in Fig. 6, the upper cover 4a and the lower cover 4b are attached to each other so as to sandwich the cartridge 2 from both sides in the axial direction A. In this manner, the adapter 4 can be attached to the cartridge 2.

[0043] As shown in FIG. 5 and FIG. 6, the adapter 4 includes an adapter flow path section 4b1. More specifically, the lower cover 4b of the adapter 4 includes the adapter flow path section 4b1. The adapter flow path section 4b1 defines an adapter flow path therein. The adapter flow path section 4b1 includes a first port section 4c1 that can be liquid-tightly connected to a flow path pipe 214 (see FIG. 10A, etc.) of the filler 3, which will be described later, and a second port section 4c2 that can be liquid-tightly connected to a connection port 37a (see FIG. 4) of the drug solution flow path 37 of the cartridge 2. As shown in FIG. 6, when the adapter 4 is attached to the cartridge 2, the adapter flow path section 4b1 passes through a recess serving as a storage section 34 formed on the lower surface of the cartridge housing 32 of the cartridge 2, and the second port section 4c2 of the adapter flow path section 4b1 is liquid-tightly connected to the connection port 37a (see FIG. 4).

[0044] Moreover, the upper cover 4a of the adapter 4 includes a container connection part 150 to which a liquid medicine container 300 (see FIG. 1) can be connected. The upper cover 4a includes a tube part 151, one end of which is exposed to the container connection part 150. As shown in FIG. 6, when the adapter 4 is attached to the cartridge 2, the other end of the tube part 151 enters the cylindrical body 36 through the filling port 36a of the cartridge 2 and enters the storage space 36b (see FIG. 3, etc.). More specifically, an elastic plug member is disposed in the filling port 36a, and the other end of the tube part 151 can penetrate the elastic plug member and enter the storage space 36b. This allows the cylindrical body 36 and the tube part 151 to communicate with each other.

[0045] 6, before the drug solution reservoir 2a is filled with the drug solution, that is, before the cartridge 2 is used, the user, such as a patient, may attach the adapter 4 to the cartridge 2. In other words, the cartridge 2 and the adapter 4 may be distributed in a state where they are not attached to each other, and the user may attach them to each other. However, the adapter 4 may be distributed in a state where it is already attached to the cartridge 2 before use.

[0046] Fig. 7 is a diagram showing the cartridge 2 with the adapter 4 attached, and the filler 3. For ease of explanation, the cartridge 2 with the adapter 4 attached will be referred to as the "adapter-attached cartridge 5" below. As shown in Fig. 7, the filler 3 has an accommodating recess 3a capable of accommodating the adapter-attached cartridge 5.

[0047] Although details will be described later, the filler 3 includes an adjustment mechanism 205 (see FIG. 11, etc.) capable of adjusting the amount of liquid medicine filled into the liquid medicine reservoir 2a of the cartridge 2. More specifically, in the filler 3 of this embodiment, the amount of liquid medicine filled into the liquid medicine reservoir 2a can be adjusted by rotating an operation dial portion 230 exposed to the outside. In the state shown in FIG. 7, i.e., before the adaptor-equipped cartridge 5 is inserted into the storage recess 3a, the amount of liquid medicine filled into the liquid medicine reservoir 2a is adjusted by the operation dial portion 230.

[0048] Fig. 8 is a diagram showing a state in which the adaptor-attached cartridge 5 is inserted into the accommodating recess 3a of the filler 3 from the state shown in Fig. 7, and the adaptor-attached cartridge 5 is accommodated in the accommodating recess 3a. At this time, the first port portion 4c1 (see Figs. 5 and 6) of the adapter 4 is liquid-tightly connected to a flow path pipe 214 (see Figs. 10A and 10B) of the filler 3, which will be described later.

[0049] In addition, although details will be described later, the filling device 3 is equipped with a locking mechanism 206 (see Figures 16 to 18C, etc.) that locks the adapter-attached cartridge 5 inserted into the accommodating recess 3a so that the adapter-attached cartridge 5 does not unintentionally come out of the accommodating recess 3a.

[0050] Next, the liquid medicine container 300 shown in Fig. 8 is connected to the container connection part 150 of the adapter 4. The liquid medicine container 300 is, for example, a vial. The liquid medicine is hermetically stored in the liquid medicine container 300 by a stopper member 301. The liquid medicine container 300 is connected to the container connection part 150 such that the tube part 151 exposed at the container connection part 150 of the adapter 4 penetrates the stopper member 301 and enters the liquid medicine container 300.

[0051] Fig. 9 is a diagram showing a state in which the liquid medicine container 300 is connected to the container connection part 150 of the adapter 4 from the state shown in Fig. 8. In the state shown in Fig. 9, by operating the operating lever part 210 of the filling device 3, the liquid medicine can be filled from the liquid medicine container 300 into the liquid medicine reservoir 2a of the cartridge 2.

[0052] 10A and 10B are diagrams for explaining the principle of filling the drug solution in the drug solution container 300 into the drug solution reservoir 2a of the cartridge 2. As shown in FIG. 10A and FIG. 10B, the filler 3 includes an operation lever portion 210, a coil spring 211, a cylindrical body 212, a plunger 213, and a flow path tube 214. The plunger 213 is configured to be movable within the cylindrical body 212 by operating the operation lever portion 210. Specifically, when a user such as a patient holds the filler 3 as if gripping it, and the operation lever portion 210 is pushed against the restoring force of the coil spring 211 (see the white arrow in FIG. 10A), the plunger 213 moves within the cylindrical body 212, and the air within the cylindrical body 212 is compressed, as shown in FIG. 10A.

[0053] The flow path pipe 214 is connected to the cylindrical body 212. As described above, the first port portion 4c1 of the adapter 4 is liquid-tightly connected to the flow path pipe 214 of the filling device 3. As described above, the second port portion 4c2 of the adapter 4 is liquid-tightly connected to the connection port 37a (see FIG. 4) of the drug solution flow path 37 of the cartridge 2. That is, the inside of the cylindrical body 212 of the filling device 3 is communicated with the storage space 36b of the cylindrical body 36 of the cartridge 2 through the flow path pipe 214 of the filling device 3, the adapter flow path in the adapter flow path portion 4b1 of the adapter 4, and the drug solution flow path 37 of the cartridge 2. Therefore, when the air in the cylindrical body 212 of the filling device 3 is compressed, the internal pressure of the storage space 36b of the cylindrical body 36 of the cartridge 2 increases. As described above, the tube portion 151 of the adapter 4 extends across the storage space 36b of the cylindrical body 36 and the inside of the drug solution container 300 through the filling port 36a. Therefore, when the internal pressure of the storage space 36b of the cylindrical body 36 of the cartridge 2 increases, the air in the storage space 36b is sent into the liquid medicine container 300 through the tube portion 151 of the adapter 4 (see the dashed arrow in FIG. 10A). As a result, the inside of the liquid medicine container 300 becomes positive pressure.

[0054] Next, the user releases the pressing of the operating lever portion 210 of the filling device 3. As a result, the operating lever portion 210 is restored to its original position by the restoring force of the coil spring 211 (see the outline arrow in FIG. 10B). That is, as shown in FIG. 10B, the plunger 213 of the filling device 3 moves back inside the cylindrical body 212, and air is drawn into the cylindrical body 212 (see the dashed arrow in FIG. 10B). As a result, the internal pressure of the storage space 36b of the cylindrical body 36 of the cartridge 2 decreases, and the liquid medicine in the liquid medicine container 300 moves to the storage space 36b of the cylindrical body 36 through the tube portion 151 of the adapter 4 (see the dashed arrow in FIG. 10B). In this way, the liquid medicine can be filled from the liquid medicine container 300 into the storage space 36b.

[0055] The user can fill the storage space 36b of the liquid medicine reservoir 2a of the cartridge 2 with a desired amount of liquid medicine by repeatedly operating the operating lever portion 210 of the filling device 3 described above.

[0056] After filling the liquid medicine reservoir 2a of the cartridge 2 with the liquid medicine, the adaptor-equipped cartridge 5 (see FIG. 9) with the liquid medicine container 300 attached is removed from the filling device 3. At this time, the user can release a locking mechanism 206 (see FIGS. 16 to 18C) of the filling device 3, which will be described later, by operating the operation protrusion 246 of the filling device 3 shown in FIGS. 7 to 9. By releasing the locking mechanism 206, the adaptor-equipped cartridge 5 with the liquid medicine container 300 attached can be pulled out from the storage recess 3a.

[0057] Next, the liquid medicine container 300 is removed from the cartridge 5 with the adapter. Furthermore, the adapter 4 is removed from the cartridge 2. In this manner, the cartridge 2 in which the liquid medicine reservoir 2a is filled with the liquid medicine can be obtained. This cartridge 2 is used as a part of the above-mentioned liquid medicine administration device 10 (see FIG. 2).

[0058] Next, the filling device 3 will be described in detail.

[0059] Fig. 11 is an exploded perspective view of the filling device 3. As shown in Fig. 11, the filling device 3 includes a main body 201, a front exterior cover 202, and a rear exterior cover 203. The main body 201 is held so as to be sandwiched between the front exterior cover 202 and the rear exterior cover 203.

[0060] As shown in Fig. 11, the main body 201 includes an accommodating recess 3a, a filling mechanism 204, an adjustment mechanism 205, a locking mechanism 206, and a shaft engaging member 207. In Fig. 11, the position of the shaft engaging member 207 is indicated by a dashed line.

[0061] As described above, the storage recess 3a is configured so that the cartridge 2 (see FIG. 7, etc.) can be inserted therein. As shown in FIG. 7 and FIG. 8, the cartridge 2 can be inserted into the storage recess 3a along the axial direction A of the cylindrical body 36. For ease of explanation, the axial direction A in which the cartridge 2 is inserted into the storage recess 3a of the filler 3 will be referred to as the "insertion direction A1." Additionally, the axial direction A in which the cartridge 2 is removed from the storage recess 3a of the filler 3 will be referred to as the "removal direction A2."

[0062] The accommodating recess 3a in this embodiment is formed by an interior cover serving as a holder 221, which will be described later.

[0063] The filling mechanism 204 is a mechanism for filling the liquid medicine reservoir 2a of the cartridge 2 with the liquid medicine. As described above, the filling mechanism 204 of this embodiment includes the operation lever portion 210, the coil spring 211, the cylindrical body 212, the plunger 213 (see FIG. 10A, etc.), and the flow path pipe 214. FIG. 20 is a perspective view showing the inside of the accommodating recess 3a of the filling device 3. As shown in FIG. 20, of the flow path pipe 214 of this embodiment, the connection portion 214a connected to the first port portion 4c1 (see FIG. 10A, FIG. 10B, etc.) of the adapter 4 is disposed in the accommodating recess 3a.

[0064] Fig. 12 is a perspective view showing the adjustment mechanism 205 extracted from the main body 201. As shown in Fig. 12, the adjustment mechanism 205 is a mechanism capable of adjusting the amount of liquid medicine filled in the liquid medicine reservoir 2a of the cartridge 2. The adjustment mechanism 205 of this embodiment includes a support 220, a holder 221, and an adjustment body 222.

[0065] 12, the holder 221 of this embodiment is an interior cover that forms the storage recess 3a. More specifically, the holder 221 of this embodiment includes a side wall portion 224, a bottom wall portion 225 provided on one end side of the side wall portion 224, and a flange portion 226 continuing to the other end side of the side wall portion 224. The storage recess 3a is formed by the side wall portion 224 that surrounds the sides of the storage recess 3a, and the bottom wall portion 225. The cartridge 2 can be inserted into the storage recess 3a from an opening end 3a1 on the opposite side to the bottom wall portion 225 side of the storage recess 3a in the insertion direction A1.

[0066] The support 220 can directly contact the stopper 52 of the cartridge 2 inserted into the storage recess 3a and support the stopper 52. FIG. 13A and FIG. 13B are diagrams showing the state in which the stopper 52 of the cartridge 2 and the support 220 come into contact when the cartridge 2 is inserted into the storage recess 3a in the insertion direction A1. FIG. 13A shows a state before the cartridge 2 is inserted into the storage recess 3a in the insertion direction A1, and FIG. 13B shows a state in which the cartridge 2 is inserted into the storage recess 3a in the insertion direction A1 and the mounting of the cartridge 2 into the filler 3 is completed. Here, the "state in which the mounting of the cartridge 2 into the filler 3 is completed" means a state in which the filling of the liquid medicine reservoir 2a of the cartridge 2 by the filler 3 can be normally performed. In this embodiment, it means a state in which the cartridge 2 is locked by a lock mechanism 206 of the filler 3 described later. Hereinafter, for convenience of explanation, the "state in which the mounting of the cartridge 2 into the filler 3 is completed" will be simply referred to as a "cartridge mounting state". As shown in FIG. 13B, the stopper 52 and the support 220 are in contact with each other when the cartridge is in the mounted state.

[0067] As shown in FIGS. 13A and 13B, when the cartridge 2 is inserted into the accommodating recess 3a, the support 220 comes into direct contact with the stopper 52 of the cartridge 2. As a result, the stopper of the cartridge 2 supports one surface of the stopper 52 on the plunger 54 side. More specifically, the support 220 of this embodiment has a protruding portion 227 that protrudes in the removal direction A2. A tip surface 227a of the protruding portion 227 is disposed at a position facing, in the axial direction A, the stopper 52 of the cartridge 2 inserted into the accommodating recess 3a. The stopper 52 of the cartridge 2 is supported by the support 220 by coming into direct contact with the tip surface 227a of the protruding portion 227 of the support 220.

[0068] The support 220 of the present embodiment includes two protruding portions 227, but there is no particular limitation on the number of protruding portions 227. The number of protruding portions 227 may be only one, or three or more.

[0069] 12, the support 220 of this embodiment is held by the holder 221 so as to be movable in the axial direction A. More specifically, the support 220 of this embodiment includes a support main body portion 228 continuing to the base end side of the protruding portion 227. The support main body portion 228 is in contact with a side wall portion 224 of the holder 221 and is held by the holder 221 so as to be movable in the axial direction A along the side wall portion 224.

[0070] 13A and 13B, the support body 228 of the support 220 of this embodiment includes an engagement portion 228a that can engage with an adjustment body 222 described later, and a protrusion 228b that fits into a long through hole 202a of the front exterior cover 202 (see FIG. 11) and is visible from the outside of the filler 3. The engagement portion 228a includes a screw groove portion 228a1 (see FIG. 15).

[0071] The adjustment body 222 can adjust the position of the support 220 in the axial direction A. FIGS. 14A and 14B show a state in which the support 220 has been moved by the adjustment body 222 to a position different from the position shown in FIGS. 13A and 13B. More specifically, the support 220 shown in FIGS. 14A and 14B has been moved in the removal direction A2 from the position shown in FIGS. 13A and 13B. Similar to FIGS. 13A and 13B, FIGS. 14A and 14B show a state in which the stopper 52 of the cartridge 2 comes into contact with the support 220 when the cartridge 2 is inserted into the accommodating recess 3a in the insertion direction A1. FIG. 14A shows a state before the cartridge 2 is inserted into the accommodating recess 3a in the insertion direction A1, and FIG. 14B shows a cartridge mounted state.

[0072] The position of the support 220 in the axial direction A is adjusted by the adjustment body 222, so that the amount of liquid medicine that can be filled into the liquid medicine reservoir 2a of the cartridge 2 can be adjusted as shown in Figs. 13B and 14B. For example, before the cartridge 2 is inserted into the storage recess 3a, the position of the support 220 in the axial direction A is moved from the position shown in Fig. 13A to the position shown in Fig. 14A by using the adjustment body 222. In this way, when the cartridge 2 is inserted into the storage recess 3a, the stopper 52 of the cartridge 2 is pushed up in the removal direction A2 more than the state shown in Fig. 13B. As a result, as shown in Fig. 14B, the stopper 52 of the cartridge 2 is positioned in the removal direction A2 more than the position shown in Fig. 13B in the cartridge mounting state. That is, the volume of the storage space 36b that can be filled with liquid medicine, which is defined by the cylinder 36 and the stopper 52, becomes smaller than the state shown in Fig. 13B. In this way, before the cartridge 2 is inserted into the accommodating recess 3a, the adjustment body 222 is used to move the position of the axial direction A of the support 220 in the removal direction A2, thereby reducing the amount of medicinal liquid that can be filled into the medicinal liquid reservoir 2a of the cartridge 2.

[0073] Moreover, when it is desired to increase the amount of liquid medicine that can be filled into the liquid medicine reservoir 2a of the cartridge 2, the above-mentioned operation can be performed in reverse. That is, before the cartridge 2 is inserted into the accommodation recess 3a, the position of the axial direction A of the support 220 is moved in the insertion direction A1 using the adjustment body 222. In this way, the amount of liquid medicine that can be filled into the liquid medicine reservoir 2a of the cartridge 2 can be increased.

[0074] Fig. 15 is a rear view of the support 220 and the adjustment body 222 shown in Figs. 13A and 13B. As shown in Fig. 15, the adjustment body 222 of this embodiment includes a shaft portion 229 that extends in the axial direction A and has a male screw portion 229a formed on the outer surface. The male screw portion 229a of the shaft portion 229 engages with the thread groove portion 228a1 of the support 220. Therefore, the support 220 can be moved in the axial direction A by rotating the shaft portion 229 about the central axis.

[0075] As shown in Figs. 11 to 15, the adjustment body 222 of this embodiment includes a disk-shaped operation dial portion 230 that protrudes radially from the shaft portion 229. The operation dial portion 230 fits into the through-hole 202b of the front exterior cover 202 (see Fig. 11) and can be operated from outside the filling device 3. That is, a user such as a patient can rotate the shaft portion 229 around the central axis by operating the operation dial portion 230 from outside the filling device 3. That is, a user such as a patient can move the support body 220 in the axial direction A by operating the operation dial portion 230 from outside the filling device 3.

[0076] As described above, the support 220 of this embodiment is provided with a protrusion 228b that fits into the through hole 202a of the front exterior cover 202 (see FIG. 11) and is visible from the outside of the filler 3. When the support 220 moves in the axial direction A, the protrusion 228b also moves in the axial direction A within the through hole 202a of the front exterior cover 202. As shown in FIG. 11, a scale portion 202c is provided near the through hole 202a of the front exterior cover 202. The scale portion 202c indicates to the outside the amount of liquid medicine that can be filled into the liquid medicine reservoir 2a of the cartridge 2. In this embodiment, when the position of the support 220 in the axial direction A is in the position shown in FIGS. 13A and 13B, the position of the protrusion 228b in the axial direction A is the same as the indication of "200U" on the scale portion 202c. 14A and 14B, the position of protrusion 228b in axial direction A is the same as the marking of "100U" on scale portion 202c. Here, the marks "100U" and "200U" on scale portion 202c represent the amount of liquid medicine that can be filled into liquid medicine reservoir 2a of cartridge 2, with "100U" meaning half the amount of "200U."

[0077] Providing such protrusion 228b allows a user such as a patient to move support 220 in axial direction A while visually checking protrusion 228b. In other words, the position of support 220 in axial direction A can be easily adjusted according to the amount of medicinal liquid to be filled in medicinal liquid reservoir 2a of cartridge 2.

[0078] 16 is a perspective view showing the locking mechanism 206 and the shaft engaging member 207 extracted from the main body 201. The locking mechanism 206 engages with the cartridge 2 inserted into the accommodating recess 3a, and restricts movement of the cartridge 2 in the axial direction A. In this way, the locking mechanism 206 prevents the cartridge 2 from being unintentionally removed from the accommodating recess 3a. The locking mechanism 206 of this embodiment includes a holder 221, a swinging body 240, a first biasing member 241, a moving body 242, and a second biasing member 243.

[0079] The holder 221 has been described in the above-mentioned adjustment mechanism 205, and therefore a description thereof will be omitted here.

[0080] The rocking body 240 is held to be rockable relative to the holding body 221. Figures 17A and 17B are views showing the rocking operation of the rocking body 240. The rocking body 240 of this embodiment is held by the holding body 221 to be rockable between a locked position (see Figure 17A) where it engages with the cartridge 2 and an unlocked position (see Figure 17B) where it is separated from the cartridge 2.

[0081] 16, 17A, and 17B, the oscillator 240 of this embodiment includes an oscillation shaft portion 244 that protrudes on both sides in the axial direction A and is journaled on a side wall portion 224 of the holder 221. As shown in Fig. 17A and 17B, the oscillator 240 is capable of oscillating around the oscillation axis line O2 relative to the holder 221, with the central axis line of the oscillation shaft portion 244 serving as the oscillation axis line O2.

[0082] In addition, the rocking body 240 of this embodiment includes a claw portion 245 that engages with the cartridge housing 32 of the cartridge 2. FIGS. 18A to 18C are views showing the operation of the rocking body 240 when the cartridge 2 is inserted into the storage recess 3a. For convenience of explanation, FIGS. 18A to 18C are schematic views showing the configurations of the cartridge 2, the moving body 242, and the second biasing member 243. FIG. 18A shows a state in which the cartridge 2 is being inserted into the storage recess 3a. FIG. 18B shows a state in which the cartridge 2 is further inserted into the storage recess 3a from the state shown in FIG. 18A and is pressed by the cartridge 2, so that the moving body 242 moves in the insertion direction A1. FIG. 18C shows a state in which the rocking body 240 rocks from the state shown in FIG. 18B and moves from the unlocked position (see FIG. 17B) to the locked position (see FIG. 17A). As shown in FIG. 18C, the claw portion 245 of the rocking body 240 of this embodiment can engage with the side wall portion 32b of the cartridge housing 32 at the lock position (see FIG. 17A) to restrict movement of the cartridge 2 in the removal direction A2.

[0083] The oscillating body 240 is held by the holder 221 so as to be able to oscillate between a locked position (see FIG. 17A) and an unlocked position (see FIG. 17B) without interfering with the support 220 of the adjustment mechanism 205 described above.

[0084] The first biasing member 241 biases the oscillator 240 to the locked position (see FIG. 17A). The first biasing member 241 of this embodiment is a torsion coil spring, and is disposed on the oscillation shaft portion 244 of the oscillator 240. One end of the torsion coil spring as the first biasing member 241 engages with the holding body 221. The other end of the torsion coil spring as the first biasing member 241 engages with the oscillator 240. In this manner, the torsion coil spring as the first biasing member 241 of this embodiment presses the oscillator 240 around the oscillation axis O2 so that the oscillator 240 is in the locked position (see FIG. 17A).

[0085] The first biasing member 241 in this embodiment is a torsion coil spring, but is not limited to this configuration. The first biasing member 241 may be, for example, an elastic body other than a torsion coil spring that biases the rocking body 240 to the lock position (see FIG. 17A).

[0086] The moving body 242 is held so as to be movable in the axial direction A relative to the holding body 221. More specifically, the moving body 242 in this embodiment is movable in the axial direction A between a supporting position and a non-supporting position. The supporting position of the moving body 242 is a position where the moving body 242 supports the rocking body 240 at the unlocked position against the biasing force of the first biasing member 241 (in this embodiment, the elastic restoring force of a torsion coil spring), as shown in Figs. 17B and 18A. The non-supporting position of the moving body 242 is a position where the moving body 242 is separated from the rocking body 240 and does not support the rocking body 240, as shown in Figs. 17A, 18B, and 18C. A part of the moving body 242 in this embodiment is fitted into a slot opening 221a (see Fig. 12) formed in the holding body 221 and extending in the axial direction A, and is movable in the axial direction A along the slot opening 221a.

[0087] The second biasing member 243 biases the moving body 242 in the removal direction A2. That is, the second biasing member 243 of this embodiment biases the moving body 242 in the removal direction A2 so that the moving body 242 is in the support position (see FIG. 17B, FIG. 18A). The moving body 242 of this embodiment can move from the support position (see FIG. 17B, FIG. 18A) to the non-support position (see FIG. 17A, FIG. 18B, FIG. 18C) by moving in the insertion direction A1 against the biasing force of the second biasing member 243 (in this embodiment, the elastic restoring force of the coil spring). The second biasing member 243 of this embodiment is a coil spring. One end of the coil spring as the second biasing member 243 is engaged with the holding body 221 or the front exterior cover 202 (see FIG. 11, etc.). The other end of the coil spring as the second biasing member 243 is engaged with the moving body 242. However, the second biasing member 243 is not limited to a coil spring. The second biasing member 243 may be an elastic body other than a coil spring that biases the moving body 242 in the removal direction A2.

[0088] As shown in FIGS. 18A to 18C, when the cartridge 2 is inserted into the accommodating recess 3a, the cartridge 2 presses the moving body 242, moving the moving body 242 from the supporting position (see FIG. 18A) to the non-supporting position (see FIG. 18B and FIG. 18C). As a result, the rocking body 240 rocks from the unlocking position (see FIG. 18A and FIG. 18B) to the locking position (see FIG. 18C) by the biasing force of the first biasing member 241, and engages with the cartridge 2. More specifically, the claw portion 245 of the rocking body 240 engages with the side wall portion 32b of the cartridge housing 32 of the cartridge 2 from the removal direction A2 side. As a result, the cartridge is in an attached state, and the movement of the cartridge 2 in the removal direction A2 is restricted.

[0089] As shown in FIG. 11, the rocking body 240 of this embodiment includes an operation protrusion 246 that fits into the through hole 202d of the front exterior cover 202 and can be operated from the outside of the filling device 3. As shown in FIG. 7 and FIG. 8, the operation protrusion 246 protrudes from the through hole 202d of the front exterior cover 202 to the outside of the front exterior cover 202. The operation protrusion 246 is movable around the rocking axis O2 within the through hole 202d. That is, by operating the operation protrusion 246, the rocking body 240 can be moved from the lock position (see FIG. 17A) to the unlock position (see FIG. 17B) against the biasing force of the first biasing member 241. In this way, the lock of the cartridge 2 by the lock mechanism 206 is released. That is, the cartridge 2 is in a state where it can be removed from the storage recess 3a in the removal direction A2. Moreover, the movable body 242 returns from the non-supporting position (see Figs. 17A, 18B, and 18C) to the supporting position (see Figs. 17B and 18A) by the biasing force of the second biasing member 243. That is, the state of the filler 3 can be changed from the state shown in Fig. 18C to the state shown in Fig. 18A. In other words, the cartridge 2 before use can be returned to a state in which it can be inserted into the accommodating recess 3a.

[0090] As shown in Figs. 16 to 18C, the shaft engagement member 207 is attached to the swinging body 240 of the lock mechanism 206 described above. More specifically, the shaft engagement member 207 of this embodiment is attached to the swinging body 240 so as to be swingable following the swinging motion of the swinging body 240 (see Figs. 17A to 18C). As shown in Fig. 18C, the shaft engagement member 207 engages with the shaft portion 54 of the cartridge 2 when the swinging body 240 is in the lock position. More specifically, the shaft portion 54 of the cartridge 2 of this embodiment includes a groove portion 54a extending in a direction perpendicular to the axial direction A. The shaft engagement member 207 of this embodiment includes a protrusion 250 that fits into the groove portion 54a of the shaft portion 54 when the swinging body 240 is in the lock position. In this way, the shaft engaging member 207 engages with the shaft portion 54, thereby suppressing the movement of the shaft portion 54 of the cartridge 2 and the stopper 52 connected to the shaft portion 54 in the removal direction A2. As described above, the support 220 directly contacts the stopper 52 and supports the stopper 52 toward the removal direction A2. That is, the support 220 can restrict the movement of the stopper 52 in the insertion direction A1 by contacting the stopper 52. However, the support 220 of this embodiment does not restrict the movement of the stopper 52 in the removal direction A2. Therefore, for example, when the accommodation space 36b (see FIG. 10A, FIG. 10B, etc.) in the cylindrical body 36 becomes negative pressure, the stopper 52 may unintentionally move in the removal direction A2. In contrast, in this embodiment, the shaft engaging member 207 that engages with the shaft portion 54 is provided, thereby suppressing the unintentional movement of the stopper 52 in the removal direction A2 described above.

[0091] Moreover, the shaft engaging member 207 is attached to the oscillator 240 so as to be movable in the axial direction A relative to the oscillator 240. Specifically, the oscillator 240 of this embodiment has a long hole 240a that is long in the axial direction A. The shaft engaging member 207 of this embodiment is provided with a fitting protrusion 251 that fits into the long hole 240a of the oscillator 240 and is movable in the axial direction A within the long hole 240a. Therefore, the shaft engaging member 207 of this embodiment is movable in the axial direction A relative to the oscillator 240 by the fitting protrusion 251 moving in the axial direction A within the long hole 240a.

[0092] Furthermore, the shaft engaging member 207 can move in the axial direction A following the movement of the support 220 of the adjustment mechanism 205 in the axial direction A. FIG. 19 is a perspective view showing the support 220, the holding body 221, the adjustment body 222, and the shaft engaging member 207 extracted from the main body 201 shown in FIG. 11. As shown in FIG. 19, the shaft engaging member 207 of this embodiment is sandwiched between the support 220 on both sides in the axial direction A. More specifically, the shaft engaging member 207 of this embodiment is sandwiched between the support body 228 of the support 220 on both sides in the axial direction A. The shaft engaging member 207 of this embodiment maintains a state in which both sides in the axial direction A are sandwiched between the support 220 whether the oscillating body 240 is in the lock position (see FIG. 17A) or the unlock position (see FIG. 17B). Therefore, when the support 220 moves in the axial direction A, the shaft engaging member 207 moves in the axial direction A following the support 220. At this time, the shaft engaging member 207 moves in the axial direction A relative to the swinging body 240. With this configuration, the position in the axial direction A of the convex portion 250 (see Figs. 16 to 18C) of the shaft engaging member 207 and the position in the axial direction A of the groove portion 54a (see Figs. 18A to 18C) of the shaft portion 54 of the cartridge 2 can be aligned simultaneously with the position adjustment in the axial direction A of the support 220. That is, the engagement of the convex portion 250 of the shaft engaging member 207 and the groove portion 54a of the shaft portion 54 shown in Fig. 18C is realized regardless of the position in the axial direction A of the support 220. That is, the convex portion 250 of the shaft engaging member 207 and the groove portion 54a of the shaft portion 54 are configured to be engaged with each other regardless of the position in the axial direction A of the support 220 shown in Figs. 13A and 13B or the position in the axial direction A of the support 220 shown in Figs. 14A and 14B.

[0093] The drug solution filling device according to the present disclosure is not limited to the specific configuration shown in the above-mentioned embodiment, and various modifications, changes, and combinations are possible without departing from the scope of the claims. In the above-mentioned embodiment, the cartridge 2 is attached to the filling device 3 via the adapter 4, but the present disclosure is not limited to this configuration. In other words, the cartridge 2 may be directly attached to the filling device 3 without the adapter 4. [Industrial Applicability]

[0094] The present disclosure relates to a drug solution filling device. [Explanation of symbols]

[0095] 2: Cartridge 2a: Drug reservoir 3: Filler 3a: Recessed portion 3a1: Open end 4: Adapter 4a: Upper cover 4b: Lower cover 4b1: Adapter flow path section 4c1: First port 4c2: Second port section 5: Cartridge with adapter 10: Drug administration device 12: Attachment section 12a: Adhesive side 14: Cradle 16: Medical solution administration device body 18: Support plate 20: Retaining wall 22: Cannula mechanism 30: Reuse Department 32: Cartridge housing 32a: Base plate part 32b: Side wall part 34: Storage unit 36: Cylinder 36a: Filling port 36b: Containment space 37: Chemical flow path 37a: Connection port 38: Plunger 39a: Cylinder body part 39b: Tip wall 40: Feed screw shaft 42: Nut part 52: Stopper 53: Sealing material 54: Shaft section 54a: Groove 64: Contact surface 74: Bearings 76: Drive unit 78:Battery 80:Motor 82: Gearbox 84: Output gear 86: Spur gear 88: Transmission shaft 90: Lid 92: Terminal 94: Bearings 100: Chemical liquid filling device 102: Nut body 104: Slide section 106: Screw hole 114: Guide wall 150: Container connection part 151: Pipe section 201: Main body of the filling device 202: Front exterior cover of the filling machine 202a: Through long hole 202b: Through hole 202c: Scale section 202d: Through hole 203: Rear exterior cover of the filling machine 204: Filling mechanism 205: Adjustment mechanism 206: Locking mechanism 207: Shaft engagement member 210: Operating lever section 211: Coil spring 212: Cylinder 213: Plunger 214: Flow pipe 214a: Connection 220:Support 221: Holding body 221a: slot opening 222: Adjustment body 224: Side wall 225: Bottom wall 226: Flange part 227:Protrusion 227a: Tip surface 228: Support body part 228a: Engagement part 228a1: Thread groove 228b:Protrusion 229: Shaft 229a: Male thread 230: Operation dial section 240: Oscillator 240a: Long hole 241: First biasing member 242: Mobile 243: Second biasing member 244: Swing shaft part 245: Claw part 246: Operation protrusion 250: Convex 251: Fitting protrusion 300: Chemical container 301: Plug member A: Axial direction A1: Insertion direction A2: Removal direction O1: Central axis of the cylinder O2: Oscillation axis of the oscillating body

Claims

1. a cartridge including a syringe-type drug reservoir; a filler capable of loading the cartridge and filling a liquid medicine reservoir of the cartridge with a liquid medicine; The drug reservoir of the cartridge includes: A cylindrical body defining a storage space capable of storing the medicinal liquid; a stopper movable along an axial direction of the cylindrical body inside the cylindrical body, The filling device is a receiving recess into which the cartridge can be inserted along the axial direction of the cylindrical body; a support body that directly contacts the stopper of the cartridge inserted into the accommodating recess and supports the stopper.

2. The filling device is a holder that holds the support body so as to be movable in the axial direction; The drug solution filling device according to claim 1 , further comprising: an adjustment body that is capable of adjusting a position of the support body in the axial direction.

3. The adjustment body includes a shaft portion extending in the axial direction and having a male thread portion formed on an outer surface thereof, The drug solution filling device according to claim 2 , wherein the support member is provided with a thread groove portion that engages with the male thread portion of the shaft portion.

4. The drug solution filling device according to claim 3 , wherein the holding body rotatably holds the shaft portion of the adjustment body.

5. the filler includes a lock mechanism that engages with the cartridge inserted into the accommodating recess and restricts movement of the cartridge in the axial direction; The locking mechanism includes: a swinging body that is swingably held by the holding body and that is swingable between a locked position where it engages with the cartridge and an unlocked position where it is separated from the cartridge; a biasing member that biases the rocking body to the lock position; a movable body that is held by the holding body so as to be movable in the axial direction, and that is movable in the axial direction between a support position that supports the rocker at the unlocked position against the biasing force of the biasing member, and a non-support position that is separated from the rocker and does not support the rocker, A drug solution filling device as described in any one of claims 2 to 4, wherein when the cartridge is inserted into the accommodating recess, the movable body is pressed and moved from the supporting position to the non-supporting position, whereby the oscillating body oscillates from the unlocked position to the locked position due to the biasing force of the biasing member and engages with the cartridge.

6. the cartridge comprises a cartridge housing that holds the drug solution reservoir; The drug solution filling device according to claim 5 , wherein the rocking body of the locking mechanism includes a claw portion that engages with the cartridge housing.

7. the cartridge includes a shaft portion protruding from the stopper, The filling device is attached to the rocking body of the locking mechanism, and is provided with a shaft engaging member that rocks following the rocking motion of the rocking body and engages with the shaft portion when the rocking body is at the lock position; The drug solution filling device according to claim 5 , wherein the shaft engaging member is attached to the rocking body so as to be movable in the axial direction relative to the rocking body, and is movable in the axial direction following the movement of the support body in the axial direction.

8. The liquid medicine filling device according to claim 2 , wherein the accommodating recess is formed in the holder.

Images