Automatic analyzer and method

Abstract

To improve inspection throughput.SOLUTION: An automatic analyzer relating to an embodiment comprises a storage unit and a control unit. The storage unit stores attribute information that shows an attribute related to cleaning to be set to any one of multiple reagents. The control unit executes, based on the attribute information, at least one of the rearrangement of a measurement order of multiple inspection items in an inspection and the determination of necessity of probe cleaning using a detergent in the inspection.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The embodiments disclosed herein and in the drawings relate to automated analytical devices and methods. [Background technology]

[0002] When testing multiple test items with an automated analyzer, the components of the reagent used in measuring the previous test item may affect the measurement of the subsequent test item. This is called reagent contamination. To avoid this reagent contamination, automated analyzers have a function to register in advance the reagents that will affect the test items, change the measurement order based on the registered reagent information, and wash the reagent dispensing probe with detergent.

[0003] However, with the diversification of test items, reagent contamination may not be avoided even if the measurement order is changed. Or, it may not be possible to change the measurement order. In such cases, it becomes necessary to wash the reagent dispensing probe with detergent, which creates a washing cycle and may reduce the throughput of the test. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2004-184410 A Summary of the Invention [Problem to be solved by the invention]

[0005] One of the problems to be solved by the embodiments disclosed in this specification and the drawings is to improve the throughput of the inspection. However, the problems to be solved by the embodiments disclosed in this specification and the drawings are not limited to the above problem. Problems corresponding to the effects of each configuration shown in the embodiments described later can also be positioned as other problems. [Means for solving the problem]

[0006] The automated analyzer according to the embodiment includes a memory unit and a controller. The memory unit stores attribute information indicating attributes related to cleaning set for any of a plurality of reagents. The controller performs at least one of rearranging the measurement order of a plurality of test items in a test and determining whether or not a probe needs to be cleaned with a detergent in the test based on the attribute information. [Brief description of the drawings]

[0007] [Figure 1] FIG. 1 is a block diagram showing an example of an automatic analyzer according to a first embodiment. [Diagram 2] FIG. 2 is a diagram illustrating an example of the configuration of the analysis mechanism of FIG. [Diagram 3] FIG. 3 is a flowchart showing an example of the operation of the reagent contamination avoidance process in the first embodiment. [Figure 4] FIG. 4 is a diagram showing an example of a display of a reagent registration window in the first embodiment. [Diagram 5] FIG. 5 is a diagram showing an example of registered reagent information in the first embodiment. [Figure 6] FIG. 6 is a diagram showing a display example of the examination item registration window (basic settings) in the first embodiment. [Figure 7] FIG. 7 is a diagram showing a display example of the test item registration window (carry-over setting) in the first embodiment. [Figure 8] FIG. 8 is a diagram showing an example of registered examination item information in the first embodiment. [Figure 9] FIG. 9 is a diagram showing the execution result of the reagent contamination avoidance process in the first embodiment. [Figure 10] FIG. 10 is a diagram showing the results of execution of the reagent contamination avoidance process in the application example of the first embodiment. [Figure 11] FIG. 11 is a flowchart showing an example of the operation of the reagent contamination avoidance process in the second embodiment. [Figure 12] FIG. 12 is a diagram showing an example of a display of a reagent registration window in the second embodiment. [Figure 13] FIG. 13 is a diagram showing an example of registered reagent information in the second embodiment. [Figure 14] FIG. 14 is a diagram showing a display example of an examination item registration window (basic settings) in the second embodiment. [Figure 15] FIG. 15 is a diagram showing a display example of the test item registration window (carry-over setting) in the second embodiment. [Figure 16] FIG. 16 is a diagram showing an example of registered examination item information in the second embodiment. [Figure 17] FIG. 17 is a diagram showing the execution result of the reagent contamination avoidance process in the second embodiment. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0008] Hereinafter, an embodiment of the automatic analyzer will be described in detail with reference to the drawings.

[0009] (First embodiment) Fig. 1 is a block diagram showing an example of an automatic analyzer according to a first embodiment. The automatic analyzer 1 shown in Fig. 1 includes an analysis mechanism 2, an analysis circuit 3, a drive mechanism 4, an input interface 5, an output interface 6, a communication interface 7, a memory circuit 8 (memory unit), and a control circuit 9 (control unit). The automatic analyzer 1 measures components in a sample by measuring a mixture of a sample to be measured and a specimen.

[0010] The analysis mechanism 2 mixes a sample, such as a standard sample or a test sample (also called a specimen), with a reagent used for each test item set for the sample. The analysis mechanism 2 measures the mixture of the sample and the reagent, and generates standard data and test data, which are expressed, for example, by absorbance.

[0011] The analysis circuit 3 is a processor that generates calibration data, analysis data, etc. by analyzing the standard data and test data generated by the analysis mechanism 2. The analysis circuit 3 reads an analysis program from the storage circuit 8, and generates calibration data, analysis data, etc. according to the read analysis program. For example, the analysis circuit 3 generates calibration data indicating the relationship between the standard data and a standard value previously set for the standard sample, based on the standard data. The analysis circuit 3 also generates analysis data expressed as a concentration value and an enzyme activity value, based on the test data and the calibration data of the test item corresponding to the test data. The analysis circuit 3 outputs the generated calibration data, analysis data, etc. to the control circuit 9.

[0012] The drive mechanism 4 drives the analysis mechanism 2 under the control of the control circuit 9. The drive mechanism 4 is realized by, for example, a gear, a stepping motor, a belt conveyor, a lead screw, and the like.

[0013] The input interface 5 receives settings such as analysis parameters for each test item related to a sample requested to be measured from, for example, an operator or via the hospital network NW. The input interface 5 is realized by, for example, a mouse, a keyboard, and a touchpad where instructions are input by touching the operation surface. The input interface 5 is connected to the control circuit 9, converts the operation instructions input by the operator into electrical signals, and outputs the electrical signals to the control circuit 9.

[0014] In this specification, the input interface 5 is not limited to an interface having physical operation parts such as a mouse, a keyboard, and a touch pad. For example, an example of the input interface 5 also includes an electrical signal processing circuit that receives an electrical signal corresponding to an operation instruction input from an external input device provided separately from the automatic analyzer 1 and outputs the electrical signal to the control circuit 9.

[0015] The output interface 6 is connected to the control circuit 9 and outputs a signal supplied from the control circuit 9. The output interface 6 is realized by, for example, a display circuit, a printed circuit, and an audio device. The display circuit includes, for example, a CRT display, a liquid crystal display, an organic EL display, an LED display, and a plasma display. The display circuit may also include a processing circuit that converts data representing a display object into a video signal and outputs the video signal to the outside. The printed circuit may include, for example, a printer. The printed circuit may also include an output circuit that outputs data representing a print object to the outside. The audio device may include, for example, a speaker. The audio device may also include an output circuit that outputs an audio signal to the outside.

[0016] The communication interface 7 is connected to, for example, a hospital network NW. The communication interface 7 performs data communication with a Hospital Information System (HIS) via the hospital network NW. The communication interface 7 may also perform data communication with a Laboratory Information System (LIS) via a laboratory department system connected to the hospital network NW.

[0017] The memory circuit 8 includes a processor-readable recording medium such as a magnetic recording medium, an optical recording medium, or a semiconductor memory. The memory circuit 8 does not necessarily have to be realized by a single storage device. For example, the memory circuit 8 may be realized by a plurality of storage devices.

[0018] The memory circuitry 8 also stores an analysis program executed by the analysis circuitry 3 and a control program for implementing functions of the control circuitry 9. The memory circuitry 8 stores analysis data generated by the analysis circuitry 3 for each test item. The memory circuitry 8 stores test orders input by an operator or test orders received by the communication interface 7 via the hospital network NW.

[0019] The memory circuitry 8 also stores reagent information related to the reagent. The reagent information includes, for example, information such as the reagent name, type, and attributes, which are associated with each other. The reagent information is not limited to reagents, and may be any liquid other than the sample loaded in the automatic analyzer 1.

[0020] The type information (type information) is, for example, the type of liquid other than the sample that is loaded into the automatic analyzer 1. Specifically, the type information includes, for example, a first reagent (R1), a second reagent (R2), a detergent for avoiding carry-over, an acidic detergent, an alkaline detergent, a diluent, and a thermostatic bath additive.

[0021] Attribute information (attribute information) indicates properties related to cleaning. Specifically, the attribute information is physical property information that indicates physical properties related to hydrogen ions contained in a reagent. The attribute information includes, for example, neutral reagents, alkaline reagents, and acidic reagents. The role of the attribute information will be described in detail later. Note that the attribute information may be set only for some reagents.

[0022] The memory circuitry 8 also stores test item information relating to the test items. The test item information is set for each of the multiple test items. The test item information includes, for example, basic setting information and carry-over setting information, which are associated with each other.

[0023] The basic setting information includes information on the test items, such as absorbance, sample, diluent, reagent, and stirrer, which are associated with each other. The information on the reagent of the test item (test item reagent information) includes, for example, the names of the first and second reagents, and the amounts of each reagent and the amount of water used for dilution. The reagent names here usually include the reagents stored in the above-mentioned reagent information.

[0024] The carryover setting information includes information about the test item, such as reagent carryover avoidance washing. The reagent carryover avoidance washing information includes information such as the name of the reagent that affects the test item (name of the influencing reagent), the washing method, the amount of detergent, the number of washings, and reagent washing permission, which are associated with each other. When a reagent with attribute information (e.g., an alkaline reagent) is set in the washing method item, the reagent washing permission information (reagent washing permission information) indicates whether or not this reagent is to be used for washing. Note that reagent washing is the implementation of an examination of a test item using a reagent that is expected to have a cleaning effect, and is not intended to only perform washing in one cycle, such as detergent washing.

[0025] The memory circuitry 8 also stores information on samples to be analyzed by the automatic analyzer 1. Specifically, the memory circuitry 8 stores information on samples to be tested (test target sample information) based on sample containers inserted into the automatic analyzer 1. The test target sample information includes an ID that identifies the sample requested to be measured. The memory circuitry 8 also stores information on one or more test items associated with the sample to be tested. The memory circuitry 8 also stores information on the order of samples to be analyzed by the automatic analyzer 1 (sample order information).

[0026] The control circuit 9 is a processor that functions as the core of the automatic analyzer 1. The control circuit 9 executes a control program stored in the memory circuit 8, thereby realizing a function corresponding to the executed control program. The function of the control circuit 9 according to the first embodiment will be described later. The control circuit 9 may include a memory area for storing at least a part of the data stored in the memory circuit 8.

[0027] Fig. 2 is a diagram showing the configuration of the analysis mechanism shown in Fig. 1. The analysis mechanism 2 shown in Fig. 2 includes a reaction disk 201, a thermostatic unit 202, a rack sampler 203, a first reagent storage 204, and a second reagent storage 205. The analysis mechanism 2 also includes a sample dispensing arm 206, a sample dispensing probe 207, a first reagent dispensing arm 208, a first reagent dispensing probe 209, a second reagent dispensing arm 210, a second reagent dispensing probe 211, an electrode unit 212, a photometry unit 213, a cleaning unit 214, and a stirring unit 215.

[0028] In the following, first, the reaction disk 201, the constant temperature section 202, the rack sampler 203, the first reagent storage 204, and the second reagent storage 205 will be described.

[0029] The reaction disk 201 holds a plurality of reaction vessels 2011 arranged in a ring shape. The reaction disk 201 transports the plurality of reaction vessels 2011 along a predetermined path. Specifically, the reaction disk 201 is alternately rotated and stopped at a predetermined time interval (hereinafter referred to as one cycle), for example, 4.5 seconds or 9.0 seconds, by the drive mechanism 4. The reaction vessels 2011 are formed of, for example, glass, polypropylene (PP), or acrylic.

[0030] The thermostatic section 202 stores a heat medium set at a predetermined temperature, and increases the temperature of the mixture contained in the reaction vessel 2011 by immersing the reaction vessel 2011 in the stored heat medium.

[0031] The rack sampler 203 movably supports a sample rack 2031 capable of holding a plurality of sample containers containing samples requested to be measured. In the example shown in Fig. 2, the sample rack 2031 capable of holding five sample containers in parallel is shown.

[0032] The rack sampler 203 is provided with a transport area for transporting the sample rack 2031 from an input position where the sample rack 2031 is input to a recovery position where the sample rack 2031 that has completed measurement is recovered. In the transport area, a plurality of sample racks 2031 aligned in the short side direction are moved in a direction D1 by a drive mechanism 4.

[0033] The rack sampler 203 is also provided with a retraction area for retracting the sample rack 2031 from the transport area in order to move the sample container held by the sample rack 2031 to a predetermined sample suction position. The sample suction position is provided, for example, at a position where the rotation path of the sample dispensing probe 207 intersects with the movement path of the opening of the sample container supported by the rack sampler 203 and held by the sample rack 2031. In the retraction area, the transported sample rack 2031 is moved in direction D2 by the drive mechanism 4.

[0034] The rack sampler 203 is also provided with a return area for returning the sample rack 2031 holding the sample container into which the sample has been aspirated to the transport area. In the return area, the sample rack 2031 is moved in a direction D3 by the drive mechanism 4.

[0035] A barcode reader for reading barcodes attached to sample containers may be provided in the rack sampler 203. The barcode reader is provided, for example, near the input position of the rack sampler 203, and reads barcodes attached to sample containers held in the sample rack 2031.

[0036] The first reagent storage 204 keeps a plurality of reagent containers 100, each containing a first reagent that reacts with a predetermined component contained in a standard sample and a test sample, cool. Although not shown in FIG. 2, the first reagent storage 204 is covered with a removable reagent cover. A reagent rack is rotatably provided within the first reagent storage 204. The reagent rack holds a plurality of reagent containers 100 arranged in a circular ring shape. The reagent rack is rotated by a drive mechanism 4.

[0037] A first reagent aspirating position is set at a predetermined position on the first reagent storage 204. The first reagent aspirating position is provided, for example, at a position where the rotation path of the first reagent dispensing probe 209 intersects with the movement path of the openings of the reagent containers 100 arranged in a circular shape on the reagent rack.

[0038] The second reagent storage 205 keeps cool a plurality of reagent containers 100 containing a second reagent that pairs with a first reagent of a two-reagent system. Although not shown in Fig. 2, the second reagent storage 205 is covered with a removable reagent cover. A reagent rack is provided in the second reagent storage 205 so as to be able to rotate. The reagent rack holds a plurality of reagent containers 100 arranged in a circular ring shape.

[0039] A second reagent aspirating position is set at a predetermined position on the second reagent storage 205. The second reagent aspirating position is provided, for example, at a position where a rotational path of a second reagent dispensing probe 211, which will be described later, intersects with a movement path of the openings of the reagent containers 100 arranged in a circular shape on the reagent rack.

[0040] Next, the sample dispensing arm 206, the sample dispensing probe 207, the first reagent dispensing arm 208, the first reagent dispensing probe 209, the second reagent dispensing arm 210, the second reagent dispensing probe 211, the electrode unit 212, the photometry unit 213, the cleaning unit 214, and the stirring unit 215 will be described.

[0041] The sample dispensing arm 206 is provided between the reaction disk 201 and the rack sampler 203. The sample dispensing arm 206 is provided so as to be movable up and down in the vertical direction and rotatable in the horizontal direction by a driving mechanism 4. The sample dispensing arm 206 holds a sample dispensing probe 207 at one end.

[0042] The sample dispensing probe 207 rotates along an arcuate rotation path in accordance with the rotation of the sample dispensing arm 206. The opening of a sample container held by a sample rack 2031 on the rack sampler 203 is positioned on this rotation path.

[0043] In addition, a sample dispensing position for dispensing the sample sucked by the sample dispensing probe 207 into the reaction vessel 2011 is provided on the rotation path of the sample dispensing probe 207. The sample dispensing position corresponds to the intersection of the rotation path of the sample dispensing probe 207 and the movement path of the reaction vessel 2011 held on the reaction disk 201.

[0044] The sample dispensing probe 207 is driven by the drive mechanism 4 and moves vertically directly above the opening of a sample container held in a sample rack 2031 on the rack sampler 203 or at a sample discharge position.

[0045] The sample dispensing probe 207 also aspirates a sample from a sample container located directly below it under the control of the control circuit 9. The sample dispensing probe 207 also discharges the aspirated sample into a reaction container 2011 located directly below the sample discharge position under the control of the control circuit 9. The sample dispensing probe 207 performs a series of dispensing operations of aspirating and discharging, for example, once per cycle.

[0046] The first reagent dispensing arm 208 is provided, for example, between the reaction disk 201 and the first reagent storage 204. The first reagent dispensing arm 208 is provided so as to be movable up and down in the vertical direction and rotatable in the horizontal direction by the drive mechanism 4. The first reagent dispensing arm 208 holds a first reagent dispensing probe 209 at one end.

[0047] The first reagent dispensing probe 209 rotates along an arc-shaped rotation path in association with the rotation of the first reagent dispensing arm 208. A first reagent aspirating position is provided on this rotation path. Also, a first reagent dispensing position for discharging the reagent aspirated by the first reagent dispensing probe 209 into the reaction vessel 2011 is set on the rotation path of the first reagent dispensing probe 209. The first reagent dispensing position corresponds to the intersection of the rotation path of the first reagent dispensing probe 209 and the movement path of the reaction vessel 2011 held on the reaction disk 201.

[0048] The first reagent dispensing probe 209 is driven by the drive mechanism 4 and moves up and down at a first reagent aspirating position or a first reagent dispensing position on the rotation orbit. The first reagent dispensing probe 209 also aspirates the first reagent from a reagent container located directly below the first reagent aspirating position under the control of the control circuit 9. The first reagent dispensing probe 209 also discharges the aspirated first reagent into a reaction container 2011 located directly below the first reagent dispensing position under the control of the control circuit 9.

[0049] The second reagent dispensing arm 210 is provided, for example, between the reaction disk 201 and the second reagent storage 205. The second reagent dispensing arm 210 is provided so as to be movable up and down in the vertical direction and rotatable in the horizontal direction by the drive mechanism 4. The second reagent dispensing arm 210 holds a second reagent dispensing probe 211 at one end.

[0050] The second reagent dispensing probe 211 rotates along an arc-shaped rotation orbit in association with the rotation of the second reagent dispensing arm 210. A second reagent aspirating position is provided on this rotation orbit. In addition, a second reagent dispensing position for discharging the reagent aspirated by the second reagent dispensing probe 211 into the reaction vessel 2011 is set on the rotation orbit of the second reagent dispensing probe 211. The second reagent dispensing position corresponds to the intersection of the rotation orbit of the second reagent dispensing probe 211 and the movement orbit of the reaction vessel 2011 held on the reaction disk 201.

[0051] The second reagent dispensing probe 211 is driven by the drive mechanism 4 and moves up and down at a second reagent aspirating position or a second reagent dispensing position on the rotation orbit. The second reagent dispensing probe 211 also aspirates the second reagent from a reagent container located directly below the second reagent aspirating position under the control of the control circuit 9. The second reagent dispensing probe 211 also discharges the aspirated second reagent into a reaction container 2011 located directly below the second reagent dispensing position under the control of the control circuit 9.

[0052] The electrode unit 212 measures the electrolyte concentration of the mixture of the sample and the reagent discharged into the reaction vessel 2011. The electrode unit 212 has an ion selective electrode (ISE) and a reference electrode. Under the control of the control circuit 9, the electrode unit 212 measures the potential between the ISE and the reference electrode for the mixture containing the ions to be measured. The electrode unit 212 outputs data of the measured potential to the analysis circuit 3 as standard data or test data.

[0053] The photometry unit 213 optically measures a predetermined component in the mixture of the sample and the reagent discharged into the reaction vessel 2011. The photometry unit 213 has a light source and a photodetector. The photometry unit 213 irradiates light from the light source under the control of the control circuit 9. The irradiated light is incident on a first side wall of the reaction vessel 2011 and is emitted from a second side wall opposite the first side wall. The photometry unit 213 detects the light emitted from the reaction vessel 2011 by the photodetector.

[0054] Specifically, for example, the photodetector detects light that has passed through a mixture of a standard sample and a reagent in the reaction vessel 2011, and generates standard data represented by absorbance or the like based on the intensity of the detected light. The photodetector also detects light that has passed through a mixture of a test sample and a reagent in the reaction vessel 2011, and generates test data represented by absorbance or the like based on the intensity of the detected light. The photometric unit 213 outputs the generated standard data and test data to the analysis circuit 3.

[0055] The cleaning unit 214 cleans the inside of the reaction vessel 2011 after the measurement of the mixed liquid has been completed by the electrode unit 212 or the photometry unit 213. The cleaning unit 214 includes a cleaning liquid supply pump (not shown) that supplies a cleaning liquid for cleaning the reaction vessel 2011. The cleaning unit 214 also includes a cleaning nozzle that ejects the cleaning liquid supplied from the cleaning liquid supply pump into the reaction vessel 2011 and sucks up the mixed liquid and the cleaning liquid in the reaction vessel 2011.

[0056] The stirring unit 215 is provided near the outer periphery of the reaction disk 201. The stirring unit 215 has a stirrer, and uses this stirrer to stir a mixture of a sample and a first reagent contained in a reaction container 2011 located at a stirring position on the reaction disk 201. Alternatively, the stirring unit 215 stirs a mixture of a sample, a first reagent, and a second reagent contained in the reaction container 2011.

[0057] 2, washing tanks for washing the reagent dispensing probes are provided on the rotation orbit of the first reagent dispensing probe 209 and on the rotation orbit of the second reagent dispensing probe 211. In the washing tanks, for example, the reagent dispensing probes are washed with a detergent.

[0058] Next, the functions of the control circuit 9 according to the first embodiment will be described. For example, the control circuit 9 has a system control function 91, an acquisition function 92, a setting function 93, and a determination function 94 by executing an operation program. In the first embodiment, a case where the system control function 91, the acquisition function 92, the setting function 93, and the determination function 94 are realized by a single processor will be described, but this is not limited to this. For example, the control circuit may be configured by combining a plurality of independent processors, and the system control function 91, the acquisition function 92, the setting function 93, and the determination function 94 may be realized by each processor executing a control program.

[0059] The control circuit 9 uses a system control function 91 to comprehensively control each part of the automatic analyzer 1 based on, for example, input information input from the input interface 5. Specifically, the control circuit 9 controls the rotational operation of the reaction disk 201, the rotational operation and dispensing operation of the sample dispensing probe 207, and the rotational operation and dispensing operation of the second reagent dispensing probe 211.

[0060] Furthermore, the control circuit 9 executes each function related to the reagent contamination avoidance process according to the read control program. The above functions include, for example, an acquisition function 92, a setting function 93, and a determination function 94. Note that the above functions may include a part of the system control function 91.

[0061] The control circuit 9 acquires the test sample information and information on one or more test items associated with the sample by the acquisition function 92. The control circuit 9 may also acquire sample order information. All of this information is stored in the memory circuit 8.

[0062] The control circuit 9 sets the measurement order of multiple test items for the sample to be tested using the setting function 93. Specifically, the control circuit 9 rearranges the measurement order based on the attribute information. When rearranging the measurement order, the control circuit 9 may identify a reagent whose attribute information includes physical property information and a test item that uses this reagent.

[0063] The control circuit 9 performs various judgments using the judgment function 94. Specifically, the control circuit 9 performs judgments regarding reagent contamination, judgment as to whether or not there is a test item that uses a reagent for which attribute information regarding cleaning is set, judgment as to whether or not probe cleaning is necessary, etc. In this specification, probe cleaning refers to detergent cleaning in which the reagent dispensing probe is washed with detergent. In addition, when probe cleaning is performed, a cycle for cleaning is required.

[0064] Next, the operation of the automated analyzer 1 according to the first embodiment configured as above will be described according to the procedure of the reagent contamination avoidance process executed by the control circuit 9.

[0065] Fig. 3 is a flowchart showing an example of the operation of the reagent contamination avoidance process in the first embodiment. The flowchart in Fig. 3 starts after the control circuit 9 acquires the test target sample information and the sample order information by the acquisition function 92. Note that the flowchart in Fig. 3 sets the measurement order of multiple test items set for one sample among the multiple samples included in the sample order information.

[0066] In the flowchart of Fig. 3, as a specific example, the measurement order of three test items (test item Ex_0001, test item Ex_0002, and test item Ex_0003) set for a certain sample is set. The following describes the reagents related to these test items and the settings of each test item with reference to Figs. 4 to 8.

[0067] Fig. 4 is a diagram showing an example of a display of a reagent registration window in the first embodiment. A reagent registration window 400 shown in Fig. 4 displays reagent information.

[0068] In the example of FIG. 4, the reagent information is associated with the reagent name "Reg_1001" and the type "first reagent (R1)" and the attribute "alkaline reagent" (attribute information 410).

[0069] Fig. 5 is a diagram showing an example of registered reagent information in the first embodiment. Registered reagent information 500 shown in Fig. 5 is information in which the reagent name, type, and attributes of the reagent installed in the automatic analyzer 1 are associated with each other.

[0070] In the example of FIG. 5, the registered reagent information 500 associates the type "first reagent (R1)" and the attribute "alkaline reagent" with the reagent name "Reg_1001." Furthermore, the registered reagent information 500 associates the type "first reagent (R1)" with each of the reagent names "Reg_1002" and "Reg_1003." Furthermore, the registered reagent information 500 associates the type "second reagent (R2)" with each of the reagent names "Reg_2001," "Reg_2002," and "Reg_2003." That is, in the example of FIG. 5, attribute information is set only for the reagent Reg_1001.

[0071] Fig. 6 is a diagram showing an example of a display of an examination item registration window (basic settings) in the first embodiment. An examination item registration window 600 shown in Fig. 6 displays basic setting information.

[0072] 6, the basic setting information is set for the test item "Ex_0003" as test item reagent information 610. The test item reagent information 610 is associated with a first reagent "Reg_1003(R1)" and a second reagent "Reg_2003(R2)".

[0073] Fig. 7 is a diagram showing a display example of the test item registration window (carry-over setting) in the first embodiment. The test item registration window shown in Fig. 7 displays carry-over setting information.

[0074] In the example of FIG. 7, reagent carry-over avoidance washing information 710 is set for the test item "Ex_0003" as carry-over setting information. In the reagent carry-over avoidance washing information 710, the influencing reagent name "Reg_1002(R1)", washing method "alkaline reagent", and reagent washing permission "checked" (reagent washing permission information 711) are associated as the first setting, and the influencing reagent name "all first reagents" and washing method "detergent for avoiding carry-over" are associated as the second setting. Note that "all first reagents" means "all first reagents". In other words, a test item for which the influencing reagent name "all first reagents" is set requires either detergent washing or a similar washing after the test of the immediately preceding test item.

[0075] Fig. 8 is a diagram showing an example of registered test item information in the first embodiment. The registered test item information 800 shown in Fig. 8 is information in which a first reagent set for a test item, a reagent that affects the test item (influencing reagent), and a cleaning method for avoiding the influence of reagent carry-over are associated with a test item registered in the automatic analyzer 1. Note that a combination of the test item, the first reagent, and a reagent that affects the test item may be referred to as influencing reagent information.

[0076] In the example of FIG. 8, the registered test item information 800 associates a first reagent "Reg_1001(R1)", an influencing reagent "Reg_1004(R1)", and a cleaning method "detergent for avoiding carry-over" with respect to the test item "Ex_0001". In addition, the registered test item information 800 associates a first reagent "Reg_1002(R1)", an influencing reagent "Reg_1005(R1)", and a cleaning method "detergent for avoiding carry-over" with respect to the test item "Ex_0002". In addition, the registered test item information 800 associates a first reagent "Reg_1003(R1)", an influencing reagent "Reg_1002(R1)", and a cleaning method "alkaline reagent" with respect to the test item "Ex_0003". Furthermore, in the registered test item information 800, the test item "Ex_0003" is associated with the first reagent "Reg_1003(R1)", the influencing reagents "all first reagents", and the cleaning method "detergent for avoiding carry-over".

[0077] (Step ST110) When the reagent contamination avoidance process starts, the control circuit 9 sets a default measurement order by the setting function 93. The default measurement order is, for example, the order of the test items registered in the test request. In the first embodiment, the default measurement order does not take reagent contamination into consideration.

[0078] In the specific example, the default measurement order is examination item "Ex_0001", examination item "Ex_0002", and examination item "Ex_0003".

[0079] (Step ST120) After setting the default measurement order, the control circuit 9 uses the judgment function 94 to judge whether or not there is a measurement sequence that may cause reagent contamination. Specifically, the control circuit 9 makes the judgment based on the basic setting information and carry-over setting information set for each of the multiple test items. If it is judged that there is a measurement sequence that may cause reagent contamination, the process proceeds to step ST130. If it is judged that there is no measurement sequence that may cause reagent contamination, the process ends.

[0080] In the specific example, since the sequence of test items "Ex_0002" and "Ex_0003" is a measurement sequence that may cause reagent contamination, the control circuit 9 determines that there is a measurement sequence that may cause reagent contamination.

[0081] (Step ST130) After it is determined that there is a measurement sequence that may cause reagent contamination, the control circuit 9 rearranges the measurement order based on the influencing reagent information using the setting function 93. The influencing reagent information is, for example, information that associates a test item, a first reagent, and a reagent that affects the test item. Note that rearrangement does not necessarily have to be performed in step ST130. For example, if the reagents that affect the test items include "all first reagents," there is a risk that the effects of reagent contamination cannot be eliminated even if rearrangement is performed.

[0082] In the specific example, the test item "Ex_0003" is associated with the influencing reagent "all first reagents", so the control circuit 9 does not rearrange the default measurement order. Note that, due to the influence of the test item in the immediately preceding sample, the control circuit 9 is not allowed to set the test item "Ex_0003" to the beginning (first) of the measurement order.

[0083] (Step ST140) After the process of step ST130, the control circuit 9 determines whether or not the occurrence of reagent contamination can be avoided by the determination function 94. The determination here is the same as the determination of step ST120. If it is determined that the occurrence of reagent contamination cannot be avoided, the process proceeds to step ST150. If it is determined that the occurrence of reagent contamination can be avoided, the process ends.

[0084] In the specific example, since no rearrangement has been performed in step ST130, the control circuit 9 determines that the occurrence of reagent contamination cannot be avoided in the current measurement order (which is the same as the default measurement order).

[0085] (Step ST150) After determining that the occurrence of reagent contamination cannot be avoided, the control circuit 9 uses the determination function 94 to determine whether or not there is a test item that uses a reagent for which attribute information related to cleaning is set. Specifically, the control circuit 9 makes the determination based on the affected reagent information and the registered reagent information. The registered test item information is information in which a cleaning method is further associated with the affected reagent information described above. The registered reagent information is information in which the reagent name, type, and attributes of the reagent installed in the automatic analyzer 1 are associated with each other. If it is determined that there is a test item that uses a reagent for which attribute information related to cleaning is set, the process proceeds to step ST160. If it is determined that there is no test item that uses a reagent for which attribute information related to cleaning is set, the process proceeds to step ST180. It should be noted that the registered test item information may be used instead of the affected reagent information.

[0086] In the specific example, the attribute "alkaline reagent" is associated with the reagent name "Reg_1001" in the registered reagent information, and the first reagent "Reg_1001(R1)" is associated with the test item "Ex_0001" in the affected reagent information, so the control circuit 9 determines that there is a test item that uses a reagent for which attribute information related to cleaning is set.

[0087] In other words, the control circuit 9 determines whether there is a first test item (e.g., test item "Ex_0001") that uses a first reagent (e.g., reagent name "Reg_1001") to which attribute information (e.g., the attribute "alkaline reagent", which is physical property information) is set in multiple test items.

[0088] (Step ST160) After determining that there is a test item that uses a reagent for which attribute information related to cleaning is set, the control circuit 9 rearranges the measurement order based on the attribute information using the setting function 93. Specifically, the control circuit 9 rearranges the measurement order based on registered test item information in which attribute information is included in the cleaning method item and registered reagent information in which attribute information is included. Note that rearrangement does not necessarily have to be performed in step ST160.

[0089] In the specific example, the test item "Ex_0003", the first reagent "Reg_1003(R1)", the influencing reagent "Reg_1002(R1)", and the cleaning method "alkaline reagent" are associated with the registered test item information, and the reagent name "Reg_1001" and the attribute "alkaline reagent" are associated with the registered reagent information. Therefore, the control circuit 9 sets the test item "Ex_0002" with the influencing reagent "Reg_1002(R1)" as the first reagent at the beginning of the measurement order, then sets the test item "Ex_0001" with the reagent name "Reg_1001" with the attribute "alkaline reagent" as the first reagent, and finally sets the test item "Ex_0003". As a result, the control circuit 9 rearranges the default measurement order to the order of the test item "Ex_0002", the test item "Ex_0001", and the test item "Ex_0003".

[0090] In other words, when the first test item is included in a plurality of test items, the control circuit 9 rearranges the measurement order based on the attribute information.

[0091] (Step ST170) After the processing of step ST160, the control circuit 9 determines, by the determination function 94, whether or not a cleaning cycle using detergent can be avoided. The determination here is the same as the determination of step ST120. The reason why it is the same as the determination of step ST120 is that if there is an order in which reagent contamination occurs, cleaning using detergent is necessary to avoid the occurrence of reagent contamination. If it is determined that a cleaning cycle using detergent cannot be avoided, the processing proceeds to step ST180. If it is determined that a cleaning cycle using detergent can be avoided, the processing ends.

[0092] In a specific example, if the measurement order is test item "Ex_0002", test item "Ex_0001", and test item "Ex_0003", the control circuit 9 determines that a cleaning cycle using detergent can be avoided because test item "Ex_0002", which uses reagent "Reg_1002" that affects test item "Ex_0003", is performed after test item "Ex_0001", which uses reagent "Reg_1001", which is expected to have the same effect as detergent cleaning.

[0093] On the other hand, if the default measurement order were used, detergent cleaning would be required after test item "Ex_0002", which uses reagent "Reg_1002", which affects test item "Ex_0003", so the control circuit 9 determines that a cleaning cycle using detergent cannot be avoided.

[0094] In other words, since the measurement order is rearranged based on the attribute information in step ST160, when the first test item is among the multiple test items, the control circuit 9 determines whether or not the probe needs to be cleaned based on the attribute information.

[0095] (Step ST180) After determining in step ST150 that there is no test item using a reagent for which attribute information related to cleaning is set, or after determining in step ST170 that a cleaning cycle using a detergent cannot be avoided, the control circuit 9 adds a cleaning cycle using a detergent to avoid reagent contamination. After step ST180, the reagent contamination avoidance process ends.

[0096] Fig. 9 is a diagram showing the execution result of the reagent contamination avoidance process in the first embodiment. For reference, the execution result 900 shown in Fig. 9 includes a measurement order using a conventional reagent contamination avoidance function (conventional function) and a measurement order using a function (reagent washing function) that performs washing with a reagent instead of detergent washing in the first embodiment.

[0097] In the execution result 900, the measurement of the conventional function is in the order of test item “Ex_0001”, test item “Ex_0002”, detergent cleaning, and test item “Ex_0003”, which requires four cycles. On the other hand, the measurement of the reagent cleaning function is in the order of test item “Ex_0002”, test item “Ex_0001”, and test item “Ex_0003”, which requires only three cycles.

[0098] The difference between the results of the reagent washing function and the results of the conventional function is whether or not attribute information is included in the reagent information. In the conventional function, since attribute information is not included in the reagent information, the means for avoiding reagent carryover are limited to normal sorting or detergent washing. With normal sorting, there are cases where sorting is not possible due to the influence of the test items in the immediately preceding sample, or even if sorting is possible, reagent carryover cannot be avoided. In such cases, detergent washing must be performed immediately before the test item in which reagent carryover may occur, and a washing cycle using detergent is generated. On the other hand, in the reagent washing function, since attribute information is included in the reagent information, if there is a reagent that can replace detergent washing, detergent washing can be replaced with a test of the test item using this reagent, and a washing cycle using detergent can be prevented from occurring.

[0099] A detailed example of the reagent washing function in the first embodiment will be described below. For example, a plurality of test items are set for a certain sample for which a test has been requested, and the set plurality of test items include a first test item, a second test item, and a third test item. The first test item uses a first reagent for which attribute information (physical property information) is set. The measurement order before sorting (default measurement order) is the first test item, the second test item, and the third test item.

[0100] In a first specific example, if a third test item is affected by reagent contamination from a second reagent used in a second test item, and if the third test item is permitted to be cleaned with a reagent for which physical property information is set as a method of avoiding the effects of reagent contamination, the automatic analyzer 1 identifies a first reagent, which is a reagent for which physical property information is set, and a first test item that uses the first reagent, and rearranges the default measurement order to the second test item, the first test item, and the third test item.

[0101] In a second specific example, when a third test item is affected by reagent contamination from all reagents used in other test items and when the third test item is permitted to be cleaned with a reagent for which physical property information is set as a method of avoiding the effects of reagent contamination, the automatic analyzer 1 identifies a first reagent, which is a reagent for which physical property information is set, and a first test item that uses the first reagent, and rearranges the default measurement order to the second test item, the first test item, and the third test item.

[0102] In a third specific example, when a third test item is affected by reagent contamination from all reagents used in other test items, and when cleaning with a reagent for which physical property information is set is permitted as a method of avoiding the influence of reagent contamination on the third test item from a second reagent used in a second test item, the automatic analyzer 1 identifies a first reagent, which is a reagent for which physical property information is set, and a first test item that uses the first reagent, and rearranges the default measurement order to the second test item, the first test item, and the third test item.

[0103] As described above, the automated analyzer according to the first embodiment stores attribute information indicating cleaning-related attributes set for any of a plurality of reagents, and performs at least one of rearranging the measurement order of a plurality of test items in a test and determining whether or not a probe needs to be washed with a detergent in a test based on the attribute information. In addition, the attribute information in the first embodiment includes physical property information indicating physical properties related to hydrogen ions contained in the reagent.

[0104] Therefore, the automatic analysis device of the first embodiment can improve test throughput by replacing detergent washing with reagent washing by performing at least one of rearranging test items based on attribute information and determining whether detergent washing is necessary based on attribute information.

[0105] (Application example of the first embodiment) In the first embodiment, a case where detergent washing requiring one cycle is performed is described. On the other hand, in an application example of the first embodiment, a case where detergent washing requiring multiple cycles is performed is described.

[0106] When replacing detergent washing requiring multiple cycles with a test item using a reagent having a cleaning effect, the control circuit 9 may replace any of the multiple cycles for performing detergent washing with a test item using a reagent having a cleaning effect. For example, the replacement in the case of performing detergent washing requiring two cycles will be described with reference to FIG. 10.

[0107] Fig. 10 is a diagram showing an execution result of the reagent contamination avoidance process in the application example of the first embodiment. For reference, the execution result 1000 shown in Fig. 10 includes a measurement order using the conventional function and a measurement order using the reagent washing function.

[0108] In the execution result 1000, the measurement of the conventional function is in the order of test item "Ex_0001", test item "Ex_0002", detergent cleaning, detergent cleaning, and test item "Ex_0003", which requires five cycles. On the other hand, the measurement of the reagent cleaning function is in the order of test item "Ex_0002", test item "Ex_0001", detergent cleaning, and test item "Ex_0003", which requires four cycles. Thus, in the execution result 1000, one cycle of the detergent cleaning, which conventionally required two cycles, has been replaced with the inspection of test item "Ex_0001".

[0109] Therefore, an automatic analyzer according to an application example of the first embodiment can improve test throughput by replacing any of multiple cycles that require detergent cleaning with a test item that uses a reagent that has a cleaning effect.

[0110] The automated analyzer according to the application of the first embodiment may set a condition that detergent cleaning must be performed in any number of cycles among multiple cycles that require detergent cleaning. Also, when performing detergent cleaning that requires multiple cycles, the automated analyzer according to the application of the first embodiment may prohibit replacement of a test item that uses a reagent with a cleaning effect with a test.

[0111] Second Embodiment In the first embodiment, a specific example of the attribute information is described as physical property information. On the other hand, in the second embodiment, a specific example of the attribute information is described as a specific test item (specific item). The configuration of the automatic analyzer according to the second embodiment is similar to the automatic analyzer 1 shown in FIG. 1 and the analysis mechanism 2 shown in FIG. 2. The configuration unique to the second embodiment will be described below.

[0112] In the second embodiment, the reagent information stored in the memory circuit 8 includes, for example, information such as the reagent name, type, attribute, and specific item (reagent), which are associated with each other. The attribute information (attribute information) in the second embodiment is cleaning information that indicates the cleaning effect for a specific test item or a specific reagent. The attribute information includes the specific item cleaning reagent. The specific item information (specific item information) includes information on the test item. Note that the specific item information may be information on the reagent used in the test item. Hereinafter, "specific item information" is defined to include at least one of "information on the test item" and "information on the reagent used in the test item."

[0113] In the second embodiment, the control circuit 9 uses the judgment function 94 to judge whether there is a test item that uses a reagent for which attribute information related to cleaning is set, judge whether there is reagent contamination, and judge whether probe cleaning is necessary.

[0114] Next, the operation of the automatic analyzer 1 according to the second embodiment configured as above will be described according to the procedure of the reagent contamination avoidance process executed by the control circuit 9.

[0115] Fig. 11 is a flowchart showing an example of the operation of the reagent contamination avoidance process in the second embodiment. The flowchart in Fig. 11 starts after the control circuit 9 acquires the test target sample information and the sample order information by the acquisition function 92. Note that the flowchart in Fig. 11 sets the measurement order of multiple test items set for one sample among the multiple samples included in the sample order information.

[0116] In the flowchart of Fig. 11, as a specific example, the measurement order of three test items (test item Ex_0011, test item Ex_0012, and test item Ex_0013) set for a certain sample is set. The following describes the reagents related to these test items and the setting of each test item with reference to Figs. 12 to 16.

[0117] Fig. 12 is a diagram showing an example of a display of a reagent registration window in the second embodiment. A reagent registration window 1200 shown in Fig. 12 displays reagent information.

[0118] In the example of Figure 12, the reagent information is associated with the reagent name "Reg_1011", the type "first reagent (R1)", the attribute "specific item cleaning reagent" (attribute information 1210), and the specific item (reagent) "Ex_0013 (Reg_1013)" (specific item information 1220).

[0119] Fig. 13 is a diagram showing an example of registered reagent information in the second embodiment. The registered reagent information 1300 shown in Fig. 13 is information in which the reagent name, type, attribute, and specific item (reagent) of the reagent installed in the automatic analyzer 1 are associated with each other.

[0120] In the example of FIG. 13, the registered reagent information 1300 associates the type "first reagent (R1)", the attribute "specific item cleaning reagent", and the specific item (reagent) "Ex_0013 (Reg_1013)" with the reagent name "Reg_1011". Also, the registered reagent information 1300 associates the type "first reagent (R1)" with the reagent names "Reg_1012" and "Reg_1013". Furthermore, the registered reagent information 1300 associates the type "second reagent (R2)" with the reagent names "Reg_2011", "Reg_2012", and "Reg_2013". That is, in the example of FIG. 13, attribute information and specific item information are set only for the reagent Reg_1011.

[0121] Fig. 14 is a diagram showing an example of a display of an examination item registration window (basic settings) in the second embodiment. An examination item registration window 1400 displayed in Fig. 14 displays basic setting information.

[0122] 14, as basic setting information, test item reagent information 1410 is set for the test item "Ex_0013." The test item reagent information 1410 is associated with a first reagent "Reg_1013(R1)" and a second reagent "Reg_2013(R2)."

[0123] Fig. 15 is a diagram showing an example of a display of an examination item registration window (carry-over setting) in the second embodiment. The examination item registration window shown in Fig. 15 displays carry-over setting information.

[0124] 15, reagent carry-over avoidance cleaning information 1510 is set for the test item "Ex_0013" as carry-over setting information. In the reagent carry-over avoidance cleaning information 1510, the influencing reagent name "all first reagents", the cleaning method "specific item cleaning reagent", and the reagent cleaning permission "checked" (reagent cleaning permission information 1511) are associated as a first setting, and the influencing reagent name "all first reagents" and the cleaning method "detergent for avoiding carry-over" are associated as a second setting.

[0125] Fig. 16 is a diagram showing an example of registered test item information in the second embodiment. Registered test item information 1600 shown in Fig. 16 is information relating to a test item registered in the automatic analyzer 1, in which a first reagent, an influencing reagent, and a cleaning method set for the test item are associated with each other.

[0126] In the example of FIG. 16, the registered test item information 1600 associates the first reagent "Reg_1011(R1)", the influencing reagent "Reg_1014(R1)", and the cleaning method "detergent for avoiding carry-over" with respect to the test item "Ex_0011". In addition, the registered test item information 1600 associates the first reagent "Reg_1012(R1)", the influencing reagent "Reg_1015(R1)", and the cleaning method "detergent for avoiding carry-over" with respect to the test item "Ex_0012". In addition, the registered test item information 1600 associates the first reagent "Reg_1013(R1)", the influencing reagent "all first reagents", and the cleaning method "specific item cleaning reagent" with respect to the test item "Ex_0013". Furthermore, in the registered test item information 1600, the test item "Ex_0013" is associated with the first reagent "Reg_1013(R1)", the influencing reagents "all first reagents", and the cleaning method "detergent for avoiding carry-over".

[0127] (Step ST210) When the reagent contamination avoidance process starts, the control circuit 9 sets a default measurement order by the setting function 93. In the second embodiment, the default measurement order does not take reagent contamination into consideration.

[0128] In the specific example, the default measurement order is examination item "Ex_0011", examination item "Ex_0012", and examination item "Ex_0013".

[0129] (Step ST220) After setting the default measurement order, the control circuit 9 uses the judgment function 94 to judge whether or not there is a test item that uses a reagent for which attribute information related to cleaning is set. Specifically, the control circuit 9 makes the judgment based on the affected reagent information and the registered reagent information. If it is judged that there is a test item that uses a reagent for which attribute information related to cleaning is set, the process proceeds to step ST230. If it is judged that there is no test item that uses a reagent for which attribute information related to cleaning is set, the process proceeds to step ST240. It should be noted that registered test item information may be used instead of affected reagent information.

[0130] In the specific example, the attribute “specific item cleaning reagent” is associated with the reagent name “Reg_1011” in the registered reagent information, and the first reagent “Reg_1011(R1)” is associated with the test item “Ex_0011” in the affected reagent information, so the control circuit 9 determines that there is a test item that uses a reagent for which attribute information related to cleaning is set.

[0131] In other words, the control circuit 9 determines whether there is a first test item (e.g., test item "Ex_1011") that uses a first reagent (e.g., reagent name "Reg_1011") to which attribute information (e.g., the attribute "specific item cleaning reagent", which is specific item information) is set for multiple test items.

[0132] (Step ST230) After determining that there is a test item using a reagent for which attribute information related to cleaning is set, the control circuit 9 rearranges the measurement order by the setting function 93 so as to fix the order of the specific test items based on the attribute information. In the specific example, the test item "Ex_0013", the first reagent "Reg_1013 (R1)", the affected reagent "all first reagents", and the cleaning method "specific item cleaning reagent" are associated with the registered test item information, and the reagent name "Reg_1011", the attribute "specific item cleaning reagent", and the specific item (reagent) "Ex_0013 (Reg_1013)" are associated with the registered reagent information. Therefore, the control circuit 9 fixes the order of the test items so that the test item "Ex_0013" is performed immediately after the test item "Ex_0011" with the reagent name "Reg_1011" as the first reagent. Therefore, the control circuit 9 rearranges the default measurement order to the order of the test item "Ex_0011", the test item "Ex_0013", and the test item "Ex_0012". Incidentally, due to the influence of the test item in the immediately preceding sample, the control circuit 9 is not allowed to set the test item "Ex_0012" to the beginning (first) of the measurement order.

[0133] In other words, when the first test item is included in a plurality of test items, the control circuit 9 rearranges the measurement order based on the attribute information.

[0134] (Step ST240) After the process of step ST220 or step ST230, the control circuit 9 judges whether or not the occurrence of reagent contamination can be avoided. The judgment here is the same as the judgment of step ST120 in Fig. 3. If it is judged that the occurrence of reagent contamination cannot be avoided, the process proceeds to step ST250. If it is judged that the occurrence of reagent contamination can be avoided, the process ends.

[0135] In the specific example, since the test items are rearranged in step ST230 in the order of "Ex_0011", "Ex_0013", and "Ex_0012", the control circuit 9 determines that the occurrence of reagent contamination can be avoided.

[0136] In other words, since the measurement order is rearranged based on the attribute information in step ST230, when the first test item is among the multiple test items, the control circuit 9 determines whether or not the probe needs to be cleaned based on the attribute information.

[0137] (Step ST250) After determining that the occurrence of reagent contamination cannot be avoided, the control circuit 9 rearranges the measurement order based on the affected reagent information while fixing the order of specific test items by the setting function 93. Note that in step ST250, rearrangement does not necessarily have to be performed, and it is not necessarily required to fix the order of specific test items.

[0138] (Step ST260) After the processing of step ST250, the control circuit 9 determines, by the determination function 94, whether or not a cleaning cycle using detergent can be avoided. The determination here is the same as the determination of step ST120. The reason why it is the same as the determination of step ST120 is that if there is an order in which reagent contamination occurs, cleaning using detergent is necessary to avoid the occurrence of reagent contamination. If it is determined that a cleaning cycle using detergent cannot be avoided, the process proceeds to step ST270. If it is determined that a cleaning cycle using detergent can be avoided, the process ends.

[0139] For example, in the default measurement order, detergent cleaning is required after any test item (here, test item "Ex_0012") that uses the reagent "All First Reagents" that affects test item "Ex_0013," so the control circuit 9 determines that a cleaning cycle using detergent cannot be avoided.

[0140] (Step ST270) After determining that the cleaning cycle using detergent cannot be avoided, the control circuit 9 adds a cleaning cycle to avoid reagent contamination. After step ST270, the reagent contamination avoidance process ends.

[0141] Fig. 17 is a diagram showing the execution result of the reagent contamination avoidance process in the second embodiment. For reference, the execution result 1700 shown in Fig. 17 includes a measurement order using a conventional reagent contamination avoidance function (conventional function) and a measurement order using a function (reagent washing function) that performs washing with a reagent instead of detergent washing in the second embodiment.

[0142] In the execution result 1700, the measurement using the conventional function is in the order of test item "Ex_0011", test item "Ex_0012", detergent cleaning, and test item "Ex_0013", and requires four cycles. On the other hand, the measurement using the reagent cleaning function is in the order of test item "Ex_0011", test item "Ex_0013", and test item "Ex_0012", and requires only three cycles. The difference between the results of the reagent cleaning function and the results of the conventional function is the same as that described in the first embodiment.

[0143] A detailed example of the reagent washing function in the second embodiment will be described below. For example, assume that a plurality of test items are set for a certain sample for which a test has been requested, and that the set plurality of test items include a first test item, a second test item, and a third test item. Also, assume that the first test item uses a first reagent for which attribute information (washing information) is set. Also, assume that the measurement order before sorting (default measurement order) is the first test item, the second test item, and the third test item.

[0144] In a first specific example, when a third test item is affected by reagent contamination from all reagents used in other test items and when the third test item is permitted to be cleaned with a reagent for which cleaning information is set as a method of avoiding the effects of reagent contamination, the automatic analyzer 1 identifies a first reagent, which is the reagent for which cleaning information is set, and the third test item as well as a specific test item set for the first reagent, and rearranges the default measurement order to fix it to the order of the first test item and the third test item.

[0145] In a second specific example, when a third test item is affected by reagent contamination from all reagents used in other test items, and when the third test item is permitted to be cleaned with a reagent for which cleaning information is set as a method of avoiding the effects of reagent contamination, the automatic analyzer 1 identifies a first reagent, which is a reagent for which cleaning information is set, a third reagent as a specific test item set for the first reagent, and a third test item that uses the third reagent, and rearranges the default measurement order to fix it to the order of the first test item and the third test item.

[0146] As described above, the automated analyzer according to the second embodiment stores attribute information indicating attributes related to cleaning set for any of a plurality of reagents, and performs at least one of rearranging the measurement order of a plurality of test items in a test and determining whether or not a probe needs to be cleaned with a detergent in a test based on the attribute information. In addition, the attribute information in the second embodiment includes cleaning information indicating the cleaning effect for a specific test item or a specific reagent.

[0147] Therefore, the automatic analysis device of the second embodiment can improve test throughput by replacing detergent washing with reagent washing by performing at least one of rearranging test items based on attribute information and determining whether detergent washing is necessary based on attribute information.

[0148] In addition, in the automatic analyzer according to the second embodiment, similar to the application example of the first embodiment, any one of the multiple cycles for detergent cleaning may be replaced with a test of a test item using a reagent having a cleaning effect.

[0149] According to at least one of the embodiments described above, the throughput of the inspection can be improved.

[0150] The term "processor" used in the above description means a circuit such as a CPU (Central Processing Unit), a GPU (Graphics Processing Unit), an Application Specific Integrated Circuit (ASIC), a programmable logic device (e.g., a Simple Programmable Logic Device (SPLD), a Complex Programmable Logic Device (CPLD), and a Field Programmable Gate Array (FPGA)). When the processor is a CPU, for example, the processor realizes a function by reading and executing a program stored in a memory circuit. On the other hand, when the processor is an ASIC, for example, instead of storing the program in a memory circuit, the function is directly incorporated as a logic circuit in the circuit of the processor. Note that each processor in the embodiment is not limited to being configured as a single circuit for each processor, but may be configured as one processor by combining multiple independent circuits to realize the function. Furthermore, multiple components in the figure may be integrated into one processor to realize the function.

[0151] In addition, each function according to the embodiment can be realized by installing a program for executing the above-mentioned processes in a computer such as a workstation and expanding the program in memory. In this case, the program for causing the computer to execute the above-mentioned method can be stored in a storage medium such as a magnetic disk (such as a hard disk), an optical disk (such as a CD-ROM or DVD), or a semiconductor memory and distributed.

[0152] Although some embodiments have been described, these embodiments are presented as examples and are not intended to limit the scope of the invention. These embodiments can be implemented in various other forms, and various omissions, substitutions, modifications, and combinations of embodiments can be made without departing from the spirit of the invention. These embodiments and their modifications are included in the scope of the invention and its equivalents as described in the claims, as well as in the scope and spirit of the invention. [Explanation of symbols]

[0153] 1 Automatic analyzer 2 Analysis mechanism 3 Analysis circuit 4. Drive mechanism 5 Input Interface 6 Output Interface 7 Communication Interface 8 Memory circuit 9 Control Circuit 91 System Control Functions 92 Acquisition Function 93 Setting Function 94 Judgment function 100 Reagent containers 201 Reaction Disk 2011 Reaction vessel 202 Constant temperature section 203 Rack Sampler 2031 Sample rack 204 Reagent Storage No. 1 205 Reagent Storage No. 2 206 Sample dispensing arm 207 Sample Dispensing Probe 208 1st Reagent Dispensing Arm 209 1st Reagent Dispensing Probe 210 Second Reagent Dispensing Arm 211 Second reagent dispensing probe 212 Electrode Unit 213 Photometric Unit 214 Cleaning Unit 215 Mixing Unit 400,1200 Reagent registration window 410,1210 Attribute information 500,1300 Registered Reagent Information 600,1400 Test item registration window 610,1410 Test item reagent information 710,1510 Reagent carryover prevention cleaning information 711,1511 Reagent cleaning permission information 800,1600 Registration inspection item information 900,1000,1700 Execution results 1220 Specific item information NW Hospital network

Claims

1. a storage unit that stores attribute information indicating attributes related to cleaning that are set for any one of a plurality of reagents; a control unit that executes at least one of rearranging the measurement order of a plurality of test items in a test and determining whether or not a probe needs to be washed with a detergent in the test based on the attribute information; An automatic analyzer comprising:

2. The control unit is determining whether or not the plurality of test items includes a first test item that uses a first reagent for which the attribute information is set; when the first test item is included in the plurality of test items, at least one of rearranging the measurement order and determining whether or not the probe needs to be washed is performed based on the attribute information. The automated analyzer according to claim 1 .

3. The attribute information includes physical property information indicating physical properties related to hydrogen ions contained in the reagent. The automatic analyzer according to claim 2 .

4. the plurality of test items include the first test item, a second test item, and a third test item; when the third test item is affected by reagent contamination from a second reagent used in the second test item, and when cleaning with a reagent for which the physical property information is set is permitted as a method for avoiding the influence of the third test item, the control unit Identifying the first reagent, which is a reagent for which the physical property information is set, and the first test item using the first reagent; rearrange the measurement order to the second test item, the first test item, and the third test item; The automatic analyzer according to claim 3.

5. the plurality of test items include the first test item, a second test item, and a third test item; when the third test item is affected by reagent contamination from all reagents used in other test items, and when cleaning with a reagent for which the physical property information is set is permitted as a method for avoiding the influence of the third test item, the control unit Identifying the first reagent, which is a reagent for which the physical property information is set, and the first test item using the first reagent; rearrange the measurement order to the second test item, the first test item, and the third test item; The automatic analyzer according to claim 3.

6. the plurality of test items include the first test item, a second test item, and a third test item; when the third test item is affected by reagent contamination from all reagents used in other test items, and when cleaning with a reagent for which the physical property information is set is permitted as a method of avoiding the influence of the second reagent used in the second test item on the third test item, Identifying the first reagent, which is a reagent for which the physical property information is set, and the first test item using the first reagent; rearrange the measurement order to the second test item, the first test item, and the third test item; The automatic analyzer according to claim 3.

7. The attribute information includes cleaning information indicating a cleaning effect for a specific test item or a specific reagent. The automatic analyzer according to claim 2 .

8. the plurality of test items include the first test item, a second test item, and a third test item; When the third test item is affected by reagent contamination from all reagents used in other test items, and cleaning with a reagent for which the cleaning information is set is permitted as a method for avoiding the influence of the third test item, the control unit Identifying the first reagent, which is a reagent for which the cleaning information is set, and the third test item, which is the specific test item set in the first reagent; rearrange the measurement order so that the measurement order is fixed to the first test item and the third test item; The automatic analyzer according to claim 7.

9. the plurality of test items include the first test item, a second test item, and a third test item; When the third test item is affected by reagent contamination from all reagents used in other test items, and cleaning with a reagent for which the cleaning information is set is permitted as a method for avoiding the influence of the third test item, the control unit Identifying the first reagent, which is a reagent for which the cleaning information is set, a third reagent, which is the specific reagent set for the first reagent, and the third test item using the third reagent; rearrange the measurement order so that the measurement order is fixed to the first test item and the third test item; The automatic analyzer according to claim 7.

10. storing attribute information indicating attributes related to cleaning that are set for any one of a plurality of reagents; and performing at least one of rearranging the measurement order of the test items in the test and determining whether or not the probe needs to be washed with detergent in the test based on the attribute information. The method comprising:

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