Liquid topical composition for skin

Abstract

To provide a liquid topical composition for skin that exhibits excellent bactericidal activity and effectively suppresses stickiness on the skin.SOLUTION: There is provided a liquid topical composition for skin, thickened with polymers, comprising at least two polymers having hydrogen bonding interactions, ethanol and / or isopropanol (component (C)), and water, wherein a tack force difference ΔF measured by a specific method is 5.0 gf or less as determined by the following formula. Tack force difference ΔF (gf)=(maximum tack force Fmax (gf))-(first measurement tack force F1 (gf)).SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a liquid composition for external use on skin. [Background technology]

[0002] In people's daily lives, public facilities, and medical and nursing care sites, the infection route of bacteria or viruses is often through contact with hands, and as a method for preventing contact infection, for example, a method of applying an alcohol-based disinfectant to hands to sterilize and disinfect them is known. As the dosage form of alcohol-based disinfectant, liquid and gel agents are generally known, and gel agents are accepted from the viewpoint of handling, and various studies are being conducted.

[0003] For example, Patent Document 1 discloses a viscous disinfectant for rubbing, which is characterized by containing a lower alcohol as a main component and further containing a carboxyvinyl polymer.

[0004] Patent Document 2 discloses a quick-drying transparent disinfectant lotion that contains 0.001 to 5 mass% of an MPC copolymer having a weight average molecular weight of 5,000 to 5,000,000 obtained by polymerizing 2-(meth)acryloyloxyethyl phosphorylcholine and a specific monomer, 0.01 to 2 mass% of a maleic anhydride-containing polymer having a weight average molecular weight of 10,000 to 3,000,000, 0.001 to 3 mass% of a basic substance, 50 mass% or more of a lower alcohol, and water.

[0005] Patent Document 3 discloses a pharmaceutical composition in the form of a gel for treating skin disorders, comprising a liquid and a high molecular weight polymer gelling agent dissolved in the liquid, the composition being characterized in that it comprises more than 90% by weight of a lower alkanol based on the total weight of the composition and less than 10% by weight of water based on the total weight of the composition.

[0006] In addition, Patent Document 4 discloses a quick-drying gel-type hand disinfectant that is characterized by incorporating a thickening agent consisting of a combination of a carboxyvinyl polymer and a cellulose-based water-soluble polymer compound into an alcohol solution that contains a bactericidal disinfectant as an active ingredient. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] Japanese Patent Application Publication No. 5-255078 [Patent Document 2] JP 2008-115125 A [Patent Document 3] Special Publication No. 9-510468 [Patent Document 4] Japanese Patent Application Publication No. 6-199700 Summary of the Invention [Problem to be solved by the invention]

[0008] One known method of using alcohol-based disinfectants is the rubbing method, in which the disinfectant is applied to the palm of the hand and then rubbed onto the hands until they dry. The rubbing method does not require special hand-washing equipment, and has been attracting attention since the publication of the CDC hand hygiene guidelines (2002) as a simple method for hand-washing.

[0009] However, when the alcohol-based disinfectant is in the form of a gel, it has been found that when the alcohol-based disinfectant is used in a rubbing method, the polymer used for gelling remains on the skin of the fingers and other parts of the body during rubbing, causing a strong sticky feeling. In Patent Documents 1 to 4, there is room for further improvement in terms of achieving both excellent bactericidal properties and an effect of suppressing stickiness.

[0010] Therefore, an object of the present invention is to provide a liquid composition for external use on the skin that has excellent bactericidal properties and also has an excellent effect of suppressing stickiness on the skin. [Means for solving the problem]

[0011] The present inventors have found that a liquid skin topical composition containing two specific polymers and having a tack strength difference ΔF in a specific range measured by a specific method can solve the above problems.The present inventors have also found that a liquid skin topical composition containing two specific polymers in specific amounts and ratios and having a specific viscosity can solve the above problems. That is, the present invention provides the following [1] and [2]. [1] A liquid skin topical composition thickened with a polymer, comprising at least two types of polymers having hydrogen bonding interactions, ethanol and / or isopropanol (component (C)), and water, wherein the difference ΔF in tack strength measured by the method described below, calculated by the formula below, is 5.0 gf or less. Difference in tack force ΔF(gf) = (maximum tack force F max (gf))-(First measurement tack force F1(gf)) <Measurement of tack strength> Using a tack tester (Rhesca "TAC-1000"), 0.8 g of the measurement sample was subjected to a tack test of 0.05 g / cm 2 For the pigskin surface that was coated with 2 A stainless steel probe having a flat circular surface at its tip was pressed against the skin at a speed of 2 mm / s with a pressing load of 150 gf for 1 second, and then the probe was lifted at a speed of 0.5 mm / s to a distance of 5 mm from the position before the probe was pressed (on the surface of the pigskin), and the tack force F (gf) was measured. The measurement of the tack force was carried out every minute until the tack force reached 0 gf. Here, the tack force of the first measurement is F1, and the maximum tack force among the tack forces obtained by the end of the measurement is F max It was decided. [2] A liquid composition for topical skin application comprising a thickening polymer (component (A)), a nonionic polymer capable of forming a hydrogen bond with component (A) (component (B)), ethanol and / or isopropanol (component (C)), and water, wherein the total content of components (A) and (B) is 0.2% by mass or more and 1.0% by mass or less, the mass ratio of component (B) to component (A) [(B) / (A)] is 0.3 or more and 1.0 or less, and the viscosity at 25°C is 10 mPa s or more and 10,000 mPa s or less. Effect of the Invention

[0012] According to the present invention, it is possible to provide a liquid composition for external use on the skin that has excellent bactericidal properties and is also excellent in preventing stickiness on the skin. [Brief description of the drawings]

[0013] [Figure 1] FIG. 2 is a graph showing the results of measuring the tack strength of the liquid skin topical preparation composition of the first embodiment of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0014] [Definition] In this specification, the term "gel-like" refers to a material having viscosity at 25°C, and preferably refers to a material having a viscosity at 25°C of 10 mPa·s or more and 10,000 mPa·s or less. In addition, in this specification, "stickiness" refers to the stickiness felt when applying an external skin preparation such as an alcohol-based disinfectant to the palm of the hand and rubbing it into the skin of the fingers, etc. (while rubbing). In addition, in this specification, the term "thickening polymer" refers to a polymer that is a prescription ingredient of an external preparation for skin, such as an alcohol-based disinfectant, which is mixed and dispersed in a range of 0.1 to 2.0 parts by mass per 100 parts by mass of deionized water, and after leaving it at 25°C for 24 hours, the viscosity of the resulting aqueous polymer solution at 25°C is 200 mPa s or more.

[0015] [Liquid skin topical composition] The liquid skin topical composition of the first embodiment of the present invention (hereinafter also simply referred to as the "composition of the first embodiment of the present invention") is a liquid skin topical composition thickened with a polymer, which contains at least two types of polymers having hydrogen bonding interactions, ethanol and / or isopropanol (component (C)), and water, and the difference ΔF in tack strength measured by the method described below, calculated using the following formula, is 5.0 gf or less. Difference in tack force ΔF(gf) = (maximum tack force F max (gf))-(First measurement tack force F1(gf)) <Measurement of tack strength> Using a tack tester (Rhesca "TAC-1000"), 0.8 g of the measurement sample was subjected to a tack test of 0.05 g / cm 2 For the pigskin surface that was coated with 2 A stainless steel probe having a flat circular surface at its tip was pressed against the skin at a speed of 2 mm / s with a pressing load of 150 gf for 1 second, and then the probe was lifted at a speed of 0.5 mm / s to a distance of 5 mm from the position before the probe was pressed (on the surface of the pigskin), and the tack force F (gf) was measured. The measurement of the tack force was carried out every minute until the tack force reached 0 gf. Here, the tack force of the first measurement is F1, and the maximum tack force among the tack forces obtained by the end of the measurement is F max It was decided.

[0016] FIG. 1 shows the results of measuring the tack strength of the composition of the first embodiment of the present invention every minute until the tack strength reached 0 gf. As shown in Figure 1, the tackiness of the first measurement, i.e., the tackiness one minute after the measurement, is defined as F1 (gf), and the maximum tackiness among the tackinesses obtained by the end of the measurement is defined as F max (gf), and the maximum tack force F max The difference between (gf) and the tack force F1(gf) in the first measurement was taken as the tack force difference ΔF(gf). The difference in tack force ΔF (gf) is 5.0 gf or less, preferably 4.5 gf or less, more preferably 4.0 gf or less, and even more preferably 3.8 gf or less, from the viewpoint of suppressing stickiness on the skin.

[0017] Furthermore, a liquid skin topical preparation composition according to a second embodiment of the present invention (hereinafter also simply referred to as the "composition of the present invention according to the second embodiment") contains a thickening polymer (component (A)), a nonionic polymer (component (B)) capable of forming a hydrogen bond with component (A), ethanol and / or isopropanol (component (C)), and water, in which the total content of components (A) and (B) is 0.2% by mass or more and 1.0% by mass or less, the mass ratio of component (B) to component (A) [(B) / (A)] is 0.3 or more and 1.0 or less, and the viscosity at 25°C is 10 mPa s or more and 10,000 mPa s or less.

[0018] The present invention has the effect of providing a liquid skin topical preparation composition that has excellent bactericidal properties and also has an excellent effect of suppressing stickiness on the skin. The reason for this is not entirely clear, but is thought to be as follows. The strong stickiness felt during the process of rubbing an external skin preparation composition such as an alcohol-based disinfectant containing a thickening polymer as a prescription component on the skin of fingers and the like and drying is believed to be due to the resistance caused by the interaction between the thickening polymer and the protein constituting the skin via hydrogen bonds.The present inventor therefore speculated that by blending a second polymer with which the thickening polymer is likely to interact via hydrogen bonds as a prescription component of the external skin preparation composition, the thickening polymer can be inhibited from interacting with the protein constituting the skin via hydrogen bonds, and the stickiness of the skin of fingers and the like is unlikely to occur. For example, when polyacrylic acid is used as an example of a thickening polymer and polyethylene glycol is used as an example of a second polymer, by blending polyacrylic acid and polyethylene glycol as formulation ingredients of a skin topical preparation composition, it is believed that the polyacrylic acid is prevented from interacting with the proteins that make up the skin, while the carboxyl groups of the polyacrylic acid interact with the ether groups of the polyethylene glycol through hydrogen bonds, resulting in an effect of suppressing stickiness on the skin.

[0019] The composition of the present invention in the first embodiment contains at least two polymers having attractive interactions by hydrogen bonds (hydrogen bond interactions), ethanol and / or isopropanol (component (C)), and water. The two polymers are preferably a thickening polymer (component (A)) and a nonionic polymer (component (B)) capable of forming hydrogen bonds with component (A). In addition, the composition of the present invention in the second embodiment contains a thickening polymer (component (A)), a nonionic polymer (component (B)) capable of forming a hydrogen bond with component (A), ethanol and / or isopropanol (component (C)), and water. The components (A), (B), and (C) are described in detail below. The liquid skin topical composition of the first and second embodiments of the present invention will hereinafter also be referred to simply as the "composition of the present invention."

[0020] <Component (A)> The composition of the present invention contains a thickening polymer (component (A)) capable of hydrogen bonding with component (B). Here, "capable of forming hydrogen bonds" means that the functional group of component (A) can form an attractive interaction with the functional group of component (B) through hydrogen bonds. Component (A) refers to a thickening polymer having at least a polar group capable of acting as a hydrogen bond donor, but may also have a polar group capable of acting as a hydrogen bond acceptor. Examples of polar groups that can act as hydrogen bond donors in component (A) include primary, secondary, and tertiary hydroxyl groups (-OH), various amide groups (-CO-NH2, -CO-NHR, -CO-NH-), amino groups (-NH2, -NHR), carboxy groups (-COOH), and sulfonic acid groups (-SO3H).

[0021] From the viewpoint of suppressing stickiness on the skin, component (A) is preferably a thickening polymer having one or more polar groups selected from the group consisting of primary and secondary hydroxyl groups (-OH), carboxy groups (-COOH), and various amide groups (-CO-NH2, -CO-NHR, -CO-NH-), and more preferably a thickening polymer having one or more polar groups selected from the group consisting of primary and secondary hydroxyl groups (-OH), and carboxy groups (-COOH).

[0022] Component (A) may be nonionic, anionic, or cationic. Examples of nonionic thickening polymers include hydroxyethyl cellulose (primary and secondary hydroxyl groups, e.g., Daicel Chemical Industries, Ltd.'s "SE-850" and Nagase & Co., Ltd.'s "Cellosize HECQP52000H"); hydroxypropyl cellulose (primary and secondary hydroxyl groups, e.g., Nippon Soda Co., Ltd.'s "HPC-H"); hydroxypropyl methylcellulose (primary and secondary hydroxyl groups, e.g., Shin-Etsu Chemical Co., Ltd.'s "Metolose 60SH-10000"); guar gum (primary and secondary hydroxyl groups, e.g., Sumitomo Dainippon Pharma Co., Ltd.'s "Fiberon S"); pullulan (primary and secondary hydroxyl groups, e.g., Hayashibara Co., Ltd.'s "Pullulan PI-20"); polyvinyl alcohol (secondary hydroxyl groups, e.g., Nippon Synthetic Chemical Industry Co., Ltd.'s "GOHSENOL EG-40"); and the like. The functional group in parentheses indicates a polar group possessed by component (A) that can act as a hydrogen bond donor.

[0023] Examples of the anionic thickening polymer include polyacrylic acid (carboxy group, for example, Noveon's "Carbopol 941, 981"); carboxyvinyl polymer (carboxy group, for example, Lubrizol Advanced Materials Inc.'s "Carbopol 980NF"); carboxymethylcellulose (primary and secondary hydroxyl groups, carboxy group, for example, Daicel Chemical Industries' "CMC Daicel 1220"); acrylic acid / alkyl methacrylate copolymer (carboxy group, for example, Noveon's "Carbopol ETD 2020"); hydrolyzate of a partially crosslinked polymer of a lower alkyl vinyl ether / maleic anhydride copolymer with a terminally unsaturated diene compound or its monoalkyl ester (carboxy group, for example, ISP's "Stabilize 06, QM"); carrageenan (primary and secondary hydroxyl groups, sulfonic acid group, for example, Mitsubishi Rayon's "Soagina LX22, xanthan gum (primary and secondary hydroxyl groups, for example, "Echo Gum T" manufactured by Sumitomo Dainippon Pharma); welan gum (primary and secondary hydroxyl groups, for example, "K1C376, K1A96" manufactured by Sansho); hydroxypropyl xanthan gum (primary and secondary hydroxyl groups, for example, "Labol Gum EX" manufactured by Sumitomo Dainippon Pharma); alkyl-modified carboxyvinyl polymer (carboxy group, for example, "Pemulen TR-1" manufactured by Lubrizol); and the like. The functional group in parentheses indicates a polar group possessed by component (A) that can act as a hydrogen bond donor.

[0024] Examples of cationic thickening polymers include aqueous solutions containing amino groups or ammonium groups in the side chains of the polymer chain or containing diallyl quaternary ammonium salts as structural units, such as cationic cellulose derivatives (primary and secondary hydroxyl groups, e.g., "Leoguard G" and "GP" manufactured by Lion, "Polymer JR-125, JR-400, JR-30M, LR-400, and LR-30M" manufactured by Union Carbide, and "Celcoat H-100 and L-200" manufactured by National Starch and Chemical); cationic guar gum derivatives (primary and secondary hydroxyl groups, e.g., "Jaguar C-13S" and "C-17" manufactured by Rhodia, and "Labor Gum CG-M, CG-M7, and CG-M8M" manufactured by Sumitomo Dainippon Pharma); and copolymers of diallyl quaternary ammonium salts (carboxy groups, "Marcoat 100, 280, and 295" manufactured by Calgon, hydroxypropyl chitosan (primary and secondary hydroxyl groups, amino group (-NH2), for example, "Chitofilmer HV-10" manufactured by Ichimaru Falcos); vinyl alcohol / vinylamine copolymer (secondary hydroxyl group, amino group (-NHR), for example, "VA-120-HCl" manufactured by Air Products); and the like. The functional group in parentheses indicates a polar group possessed by component (A) that can act as a hydrogen bond donor.

[0025] Of these, from the viewpoint of suppressing stickiness on the skin, component (A) is preferably one or more selected from the group consisting of nonionic thickening polymers and anionic thickening polymers, more preferably one or more selected from the group consisting of hydroxyethyl cellulose, hydroxypropyl cellulose, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, and polyacrylic acid, and even more preferably one or more selected from the group consisting of hydroxyethyl cellulose, hydroxypropyl cellulose, carboxyvinyl polymer, and polyacrylic acid.

[0026] The content of component (A) in the composition of the present invention is, from the viewpoint of suppressing stickiness on the skin and from the viewpoint of usability such as spreadability on the skin, preferably 0.05% by mass or more, more preferably 0.08% by mass or more, even more preferably 0.1% by mass or more, and is preferably 5% by mass or less, more preferably 3% by mass or less, even more preferably 1% by mass or less, and even more preferably 0.5% by mass or less.

[0027] <Ingredient (B)> The composition of the present invention contains a nonionic polymer (component (B)) capable of forming hydrogen bonds with component (A). Component (B) does not meet the definition of a thickening polymer as described above. Specifically, it refers to a polymer that is a prescription ingredient of an external preparation for skin, such as an alcohol-based disinfectant, that is mixed and dispersed in a range of 0.1 to 2.0 parts by mass per 100 parts by mass of deionized water, and left to stand at 25°C for 24 hours, after which the viscosity of the aqueous polymer solution at 25°C is less than 200 mPa s.

[0028] Here, "capable of forming hydrogen bonds" means that the functional group of component (B) has an attractive interaction with the functional group of component (A) through hydrogen bonding. Component (B) refers to a nonionic polymer that has no hydrogen bond donors other than at the ends, but has hydrogen bond acceptors. Examples of polar groups that can act as hydrogen bond acceptors in component (B) include ether groups (-O-), imino groups (>C=N-), carbonyl groups (>C=O), nitrile groups (-C≡N), amino groups (-NR2), and siloxane bonds (-Si-O-Si-).

[0029] From the viewpoint of suppressing stickiness on the skin, component (B) is preferably a nonionic polymer having one or more polar groups selected from the group consisting of an ether group (-O-), an imino group (>C=N-), a carbonyl group (>C=O), an amino group (-NR2), and a siloxane bond (-Si-O-Si-), and more preferably a nonionic polymer having one or more polar groups selected from the group consisting of an ether group (-O-), an imino group (>C=N-), and a carbonyl group (>C=O).

[0030] When the polar group capable of acting as a hydrogen bond donor in component (A) is a primary or secondary hydroxyl group (-OH), the polar group capable of acting as a hydrogen bond acceptor in component (B) is preferably one or more selected from the group consisting of an ether group (-O-), an imino group (>C=N-), a carbonyl group (>C=O), an amino group (-NR2), and a siloxane bond (-Si-O-Si-). When the polar group capable of acting as a hydrogen bond donor in component (A) is a carboxy group (-COOH), the polar group capable of acting as a hydrogen bond acceptor in component (B) is preferably one or more selected from the group consisting of an ether group (-O-), an imino group (>C=N-), a carbonyl group (>C=O), an amino group (-NR2), and a siloxane bond (-Si-O-Si-).

[0031] A preferred combination of components (A) and (B) is a thickening polymer (component (A)) having one or more polar groups selected from the group consisting of primary and secondary hydroxyl groups (-OH), and carboxyl groups (-COOH), and a nonionic polymer (component (B)) having one or more polar groups selected from the group consisting of ether groups (-O-), imino groups (>C=N-), amino groups (-NR2), and carbonyl groups (-C=O). Among these, a preferred combination of components (A) and (B) is a combination of a thickening polymer (component (A)) having one or more polar groups selected from the group consisting of primary hydroxyl groups and carboxy groups (-COOH) and a nonionic polymer (component (B)) having one or more polar groups selected from the group consisting of ether groups (-O-) and carbonyl groups (-C=O).

[0032] Examples of component (B) include polyethylene glycol (ether group, e.g., Macrogol 20000, 6000, 4000, and PEG-1540 manufactured by Sanyo Chemical Industries); polyvinylpyrrolidone (imino group, carbonyl group, Luviskol K-12, K-30, and PVP K-120 manufactured by BASF); (PEG-15 / lauryl dimethicone) crosspolymer (ether group, siloxane bond, e.g., Silicone KSG-320 manufactured by Shin-Etsu Chemical Co., Ltd.); and the like. The functional group in parentheses indicates a polar group possessed by component (A) that can act as a hydrogen bond acceptor.

[0033] The average molecular weight of component (B) is, from the viewpoint of suppressing stickiness on the skin, preferably 1,000 or more, more preferably 1,500 or more, even more preferably 3,000 or more, even more preferably 5,000 or more, even more preferably 7,000 or more, and even more preferably 8,000 or more, and from the viewpoint of solubility in the formulation and spreadability on the skin, preferably 50,000 or less, more preferably 40,000 or less, even more preferably 30,000 or less, and even more preferably 25,000 or less. Here, the average molecular weight of component (B) is a number average molecular weight measured by the method described in the average molecular weight test of Macrogol 20,000 in each monograph of pharmaceuticals in the "Japanese Pharmacopoeia, 17th Edition."

[0034] The content of component (B) in the composition of the present invention is, from the viewpoint of suppressing stickiness on the skin and from the viewpoint of usability such as spreadability on the skin, preferably 0.01% by mass or more, more preferably 0.05% by mass or more, even more preferably 0.08% by mass or more, still more preferably 0.1% by mass or more, and is preferably 5% by mass or less, more preferably 3% by mass or less, even more preferably 1% by mass or less, and still more preferably 0.5% by mass or less.

[0035] The composition of the present invention in the first embodiment essentially contains, as prescription components, at least two kinds of polymers (preferably components (A) and (B)) having attractive interactions due to hydrogen bonds (hydrogen bonding interactions), and the composition of the present invention in the second embodiment essentially contains, as prescription components, components (A) and (B), but may contain other polymers as long as the effects of the present invention are not impaired. The content of other polymers in the composition is preferably 0.01% by mass or less, more preferably 0.001% by mass or less, and even more preferably essentially 0% by mass, from the viewpoint of suppressing stickiness on the skin and from the viewpoint of usability such as spreadability on the skin. Examples of other polymers include quaternized polyvinylpyrrolidone derivatives ("Gaffcoat 734, 755, and 755N" manufactured by ISP Japan), ethylene / propylene / styrene copolymers, hydrogenated polybutene, hydrogenated styrene / isoprene copolymers, and polyethylene.

[0036] The total content of component (A) and component (B) in the composition of the present invention, from the viewpoint of suppressing stickiness on the skin and from the viewpoint of usability such as spreadability on the skin, is 0.2 mass% or more, preferably 0.25 mass% or more, more preferably 0.3 mass% or more, even more preferably 0.35 mass% or more, even more preferably 0.4 mass% or more, even more preferably 0.5 mass% or more, and is 1.0 mass% or less, preferably 0.95 mass% or less, more preferably 0.9 mass% or less, even more preferably 0.85 mass% or less, even more preferably 0.8 mass% or less, and even more preferably 0.75 mass% or less.

[0037] The mass ratio of component (B) to component (A) [(B) / (A)], from the viewpoint of suppressing stickiness on the skin and from the viewpoint of usability such as spreadability on the skin, is preferably 0.2 or more, more preferably 0.25 or more, even more preferably 0.3 or more, even more preferably 0.35 or more, even more preferably 0.4 or more, and is preferably 1.5 or less, more preferably 1.0 or less, even more preferably 0.95 or less, even more preferably 0.90 or less, and even more preferably 0.85 or less.

[0038] <Ingredient (C)> The composition of the present invention contains ethanol and / or isopropanol (component (C)), preferably ethanol. Component (C) acts as a disinfectant. It should be noted that Reference 1 reports that when the composition contains 52% by mass or more of ethanol, the composition has a bactericidal effect. <Reference 1> Testing Facility: BioScience Laboratories Inc. GLP Test Report No. 150808-101 Date January 17, 2018 (Obtained by ACI (American Detergent Industry Association), data submitted to FDA)).

[0039] From the viewpoint of bactericidal activity, the content of component (C) in the composition of the present invention is preferably 40 mass% or more, more preferably 45 mass% or more, even more preferably 50 mass% or more, still more preferably 52 mass% or more, and is preferably 95 mass% or less, more preferably 90 mass% or less, even more preferably 85 mass% or less, even more preferably 80 mass% or less, and even more preferably 75 mass% or less. When ethanol is used alone as component (C), the content of ethanol in the composition of the present invention is, from the viewpoint of bactericidal activity, preferably 40% by mass or more, more preferably 45% by mass or more, even more preferably 50% by mass or more, still more preferably 52% by mass or more, and preferably 95% by mass or less, more preferably 90% by mass or less, even more preferably 85% by mass or less, even more preferably 80% by mass or less, and even more preferably 75% by mass or less. On the other hand, when ethanol and isopropanol are used in combination as component (C), the mixing ratio of ethanol / isopropanol (mass ratio) is preferably 50 / 50 to 99 / 1, more preferably 80 / 20 to 99 / 1.

[0040] <Ingredient (D)> It is preferable that the composition of the present invention further contains a nonionic surfactant (component (D)) having a lipophilic group having from 12 to 18 carbon atoms and an HLB (hydrophilic-lipophilic balance) of from 8.0 to 17.0.

[0041] In component (D), the lipophilic group having 12 to 18 carbon atoms may be a monohydric alcohol residue having 12 to 18 carbon atoms or a fatty acid residue having 12 to 18 carbon atoms. From the viewpoint of suppressing stickiness on the skin, the lipophilic group having 12 to 18 carbon atoms is preferably a chain hydrocarbon group, more preferably a straight-chain aliphatic group, and more preferably the straight-chain aliphatic group is a straight-chain saturated aliphatic group. The number of carbon atoms in the lipophilic group in component (D) is preferably 12 to 14, more preferably 12 carbon atoms. More specifically, the lipophilic group having 12 to 18 carbon atoms in component (D) is preferably R 11 -O-, R 12 -COO- and R 12 Preferably, R is one or more selected from the group consisting of groups represented by -CONH-. 11 -O- and R 12 More preferably, R is one or more selected from the group consisting of groups represented by -COO-.11 More preferably, R is a group represented by -O-. 11 is an aliphatic group having 12 to 18 carbon atoms, preferably 12 to 14 carbon atoms, and more preferably 12 carbon atoms; R 12 represents an aliphatic group having 11 or more and 17 or less carbon atoms, preferably 11 or more and 13 or less carbon atoms, and more preferably 11 carbon atoms. R 11 and R 12 From the viewpoint of suppressing stickiness on the skin, the aliphatic group in is preferably a straight-chain aliphatic group, and more preferably a straight-chain saturated aliphatic group.

[0042] Component (D) may have only one lipophilic group having 12 to 18 carbon atoms, or may have two or more. From the viewpoint of suppressing stickiness on the skin, component (D) is preferably mainly composed of a nonionic surfactant having only one lipophilic group having 12 to 18 carbon atoms. The term "main component" as used herein means that the main component preferably accounts for 50% by mass or more, more preferably 70% by mass or more, and even more preferably 80% by mass or more of component (D), and may be 100% by mass.

[0043] Specific examples of component (D) include polyoxyethylene alkyl ethers having a linear monohydric alcohol residue or fatty acid residue having from 12 to 18 carbon atoms, sucrose fatty acid esters, polyoxyethylene fatty acid esters, polyglyceryl alkyl ethers, fatty acid polyglyceryls, alkyl glucosides, polyoxyethylene alkylamines, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and the like, and one or more of these can be used. Among these, from the viewpoint of suppressing stickiness on the skin, component (D) is preferably one or more selected from the group consisting of polyoxyethylene alkyl ethers, sucrose fatty acid esters, polyoxyethylene fatty acid esters, polyglyceryl alkyl ethers, fatty acid polyglyceryls, alkyl glucosides, and polyoxyethylene alkylamines.

[0044] Among the above, one or more selected from the group consisting of polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene alkylamine, polyoxyethylene sorbitan fatty acid ester, and polyoxyethylene sorbit fatty acid ester are preferred, and one or more selected from the group consisting of polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, and polyoxyethylene alkylamine are more preferred. The average number of moles of these oxyethylene groups added (hereinafter referred to as "average number of moles of EO added") is preferably 2 or more, more preferably 3 or more, from the viewpoint of improving the solubility and stability of the composition, and is preferably 25 or less, more preferably 24 or less, even more preferably 23 or less, and even more preferably 22 or less, from the viewpoint of suppressing stickiness on the skin and obtaining a desired HLB value. The average number of moles of EO added is a number average value.

[0045] From the viewpoint of improving the solubility and stability of the composition, component (D) has an HLB of preferably 6.0 or more, more preferably 6.5 or more, more preferably 7.0 or more, even more preferably 7.5 or more, still more preferably 8.0 or more, and preferably 18.0 or less, more preferably 17.5 or less, even more preferably 17.0 or less, still more preferably 16.8 or less. HLB (hydrophilic-lipophilic balance) indicates the ratio of the molecular weight of the hydrophilic group to the total molecular weight of a nonionic surfactant, and is calculated by the following Griffin formula. HLB = 20 x (molecular weight of hydrophilic group in nonionic surfactant molecular weight / molecular weight of nonionic surfactant)

[0046] From the viewpoint of suppressing stickiness on the skin, the content of component (D) in the composition of the present invention is preferably 0.01 mass% or more, more preferably 0.03 mass% or more, even more preferably 0.05 mass% or more, even more preferably 0.08 mass% or more, even more preferably 0.15 mass% or more, and is preferably 2.0 mass% or less, more preferably 1.8 mass% or less, even more preferably 1.5 mass% or less, even more preferably 1.2 mass% or less, even more preferably 1.0 mass% or less, and even more preferably 0.8 mass% or less.

[0047] The composition of the present invention may further contain a moisturizing agent (component (E)), a pH adjuster (component (F)), and a powder feel enhancer (component (G)).

[0048] <Ingredient (E)> Examples of the component (E) include N-(tetradecyloxyhydroxypropyl)-N-hydroxyethyldecanamide. When the composition of the present invention contains component (E), the content thereof is preferably 0.001 mass% or more, more preferably 0.008 mass% or more, even more preferably 0.01 mass% or more, and preferably 1 mass% or less, more preferably 0.5 mass% or less, even more preferably 0.1 mass% or less.

[0049] <Component (F)> Examples of the component (F) include triethanolamine, sodium hydroxide, potassium hydroxide, 2-amino-2-methyl-1-propanol, hydrochloric acid, citric acid, acetic acid, malic acid, and sulfuric acid. When the composition of the present invention contains component (F), the content thereof is preferably 0.001 mass% or more, more preferably 0.008 mass% or more, even more preferably 0.01 mass% or more, and preferably 1 mass% or less, more preferably 0.5 mass% or less, even more preferably 0.1 mass% or less.

[0050] <Ingredients (G)> Examples of component (G) include talc, silicone powder, nylon powder, lauroyl lysine, mica, boron nitride, etc., and among these, from the viewpoint of suppressing stickiness on the skin, one or more selected from the group consisting of talc, lauroyl lysine, mica, and boron nitride are preferred, and talc is more preferred. When the composition of the present invention contains component (G), the content thereof is preferably 0.001 mass% or more, more preferably 0.08 mass% or more, even more preferably 0.10 mass% or more, still more preferably 0.12 mass% or more, and is preferably 5 mass% or less, more preferably 3 mass% or less, and even more preferably 1 mass% or less.

[0051] The composition of the present invention may further contain the following components (H), (I), (J), (K) and (L). Component (H): Polyol that satisfies (number of OH groups / number of C atoms) < 1 Component (I): one or more acids or salts thereof selected from the group consisting of lactic acid, pyruvic acid, and urocanic acid Ingredient (J): Non-alcohol-based disinfectant Ingredient (K): Oily feel enhancer Ingredient (L): Skin protectant

[0052] <Component (H)> The composition of the present invention may contain, as component (H), a polyol that satisfies the ratio (number of OH groups / number of C atoms) < 1. From the viewpoints of reducing irritation to the skin and suppressing rough hands, and improving bactericidal activity and its sustained effect, component (H) preferably contains a polyol (h-1) having a (number of OH groups / number of C atoms) of more than 0.45 and a polyol (h-2) having a (number of OH groups / number of C atoms) of 0.45 or less. Polyol (h-1) not only reduces irritation to the skin and helps prevent rough hands, but also, when present together with polyol (h-2), suppresses the volatilization of polyol (h-2), which is a bactericidal component, and can contribute to improving the bactericidal activity of polyol (h-2) and its sustained effect.

[0053] (Polyol (h-1)) The (number of OH groups / number of C atoms) of the polyol (h-1) is more than 0.45, preferably 0.46 or more, preferably 0.47 or more, more preferably 0.48 or more, from the viewpoint of reducing irritation to the skin and suppressing rough hands, and from the viewpoint of suppressing volatilization of the polyol (h-2), which is a bactericidal component, and is less than 1, more preferably 0.9 or less, even more preferably 0.8 or less, and still more preferably 0.7 or less.

[0054] The polyol (h-1) is preferably a low molecular weight compound from the viewpoint of reducing skin irritation and suppressing rough hands, and from the viewpoint of suppressing the volatilization of the polyol (h-2) which is a bactericidal component. The molecular weight of the polyol (h-1) is preferably 1,000 or less, more preferably 800 or less, even more preferably 500 or less, even more preferably 200 or less, even more preferably 150 or less, and also preferably 50 or more, more preferably 60 or more, even more preferably 70 or more, even more preferably 80 or more.

[0055] The number of C atoms of polyol (h-1) is preferably 3 or more, more preferably 4 or more, from the viewpoint of reducing irritation to the skin and suppressing rough hands, and from the viewpoint of suppressing volatilization of polyol (h-2), which is a bactericidal component, and is preferably 24 or less, more preferably 18 or less, even more preferably 12 or less, still more preferably 8 or less, and even more preferably 6 or less. In addition, the number of OH groups in polyol (h-1) is preferably 2 or more and 6 or less, more preferably 2 or more and 5 or less, even more preferably 2 or more and 4 or less, and even more preferably 2, from the viewpoint of reducing irritation to the skin and suppressing rough hands, and from the viewpoint of suppressing volatilization of polyol (h-2), which is a bactericidal component.

[0056] The polyol (h-1) may be a chain polyol or a polyol having a cyclic structure, and any of these may be used, but from the viewpoint of reducing irritation to the skin and suppressing rough hands, and from the viewpoint of suppressing the volatilization of the polyol (h-2) which is a bactericidal component, it is preferably a chain polyol, more preferably a chain diol or a chain triol, and even more preferably a chain diol. Note that in the chain polyol, the bonding position of the OH group is not particularly limited.

[0057] Examples of the linear polyol used as the polyol (h-1) include linear diols such as propylene glycol (1,2-propanediol) (0.67), 1,3-propanediol (0.67), 1,2-butylene glycol (0.5), 1,3-butylene glycol (0.5), 1,4-butylene glycol (0.5), and 2,3-butanediol (0.5); Linear triols such as 1,2,3-butanetriol (0.75), 1,2,4-butanetriol (0.75), 1,2,5-pentanetriol (0.6), 1,2,6-hexanetriol (0.5); Branched diols or triols such as 2-methyl-1,3-propanediol (0.5); Sugar alcohols with a ratio (number of OH groups / number of C atoms) of more than 0.45 and less than 1, such as maltitol (0.75), lactitol (0.75), and isomaltose (0.66); Polymers such as polyglycerin having a ratio (number of OH groups / number of C atoms) of more than 0.45 and less than 1; and the like, and one or more of these may be contained. The numbers in parentheses indicate the value of (number of OH groups / number of C atoms).

[0058] Among the above, from the viewpoint of reducing irritation to the skin and suppressing rough hands, and from the viewpoint of suppressing volatilization of the polyol (h-2) which is a bactericidal component, the polyol (h-1) is preferably one or more selected from the group consisting of propylene glycol (1,2-propanediol), 1,3-butylene glycol, 1,2,6-hexanetriol, and 1,4-butylene glycol, more preferably one or more selected from the group consisting of propylene glycol (1,2-propanediol) and 1,3-butylene glycol, and even more preferably 1,3-butylene glycol.

[0059] (Polyol (h-2)) From the viewpoint of improving the bactericidal activity and its sustained effect, the (number of OH groups / number of C atoms) of the polyol (h-2) is 0.45 or less, preferably 0.40 or less, more preferably 0.35 or less, and also preferably 0.10 or more, more preferably 0.15 or more, and even more preferably 0.17 or more.

[0060] From the viewpoint of improving bactericidal activity and its sustained effect, polyol (h-2) is preferably a low molecular weight compound.Specifically, the molecular weight of polyol (h-2) is preferably 1,000 or less, more preferably 800 or less, even more preferably 500 or less, even more preferably 200 or less, even more preferably 150 or less, and also preferably 70 or more, more preferably 80 or more, even more preferably 90 or more, even more preferably 100 or more.

[0061] The number of C atoms in the polyol (h-2) is preferably 5 or more, more preferably 6 or more, from the viewpoint that the hydrophobic portion containing a C atom distorts or destroys the three-dimensional hydrogen bond network of water, and is preferably 24 or less, more preferably 20 or less, even more preferably 16 or less, still more preferably 12 or less, and even more preferably 11 or less. In addition, the number of OH groups in the polyol (h-2) is preferably 2 or more and 5 or less, more preferably 2 or more and 4 or less, even more preferably 2 or more and 3 or less, and even more preferably 2, from the viewpoint of improving the bactericidal activity and its sustained effect.

[0062] The polyol (h-2) may be a chain polyol or a polyol having a cyclic structure, and any of these may be used, but from the viewpoint that the hydrophobic part containing a C atom distorts or destroys the three-dimensional hydrogen bond network of water, it is preferably a chain polyol, more preferably a chain diol or a chain triol, and even more preferably a chain diol. Note that in the chain polyol, the bonding position of the OH group is not particularly limited.

[0063] Examples of the chain polyol used as polyol (h-2) include dipropylene glycol (0.33), tripropylene glycol (0.22), 1,2-pentanediol (0.44), 1,5-pentanediol (0.44), 1,2-hexanediol (0.33), 2,5-hexanediol (0.33), 1,6-hexanediol (0.33), 1,2-heptanediol (0.29), 1,7-heptanediol (0.29), 1,2-octanediol (0.29), and the like. linear diols such as diol (0.25), 1,8-octanediol (0.25), 1,2-nonanediol (0.22), 1,9-nonanediol (0.22), 1,2-decanediol (0.2), 1,10-decanediol (0.2), 1,2-dodecanediol (0.17), 1,12-dodecanediol (0.17), 1,2-tetradecanediol (0.14), 1,2-hexadecanediol (0.13), and 1,16-hexadecanediol (0.13); Linear triols such as 1,2,7-heptanetriol (0.43), 1,2,8-octanetriol (0.38), 1,2,9-nonanetriol (0.33), and 1,2,10-decanetriol (0.3); Branched diols or triols such as 2,2-dimethyl-1,3-propanediol (0.4), 3-methyl-1,3-butanediol (0.4), 2-methylpentane-2,4-diol (0.33), 2-ethyl-1,3-hexanediol (0.25), 2-butyl-2-ethyl-1,3-propanediol (0.22), 3-(2-ethylhexyloxy)-1,2-propanediol (0.18), (lauryl / myristyl) glycol hydroxypropyl ether (0.12-0.13), and 3,7,11,15-tetramethylhexadecane-1,2,3-triol (0.15); and and polymers such as polyethylene glycol having a ratio (number of OH groups / number of C atoms) of 0.45 or less. One or more of these may be contained. The numbers in parentheses indicate the value of (number of OH groups / number of C atoms).

[0064] Among the above, from the viewpoint of improving the bactericidal activity and its sustained effect, the polyol (h-2) is preferably one or more selected from the group consisting of dipropylene glycol, tripropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, 1,2-octanediol, 1,8-octanediol, 1,2-nonanediol, 1,9-nonanediol, 1,2-decanediol, 1,10-decanediol, 1,2-dodecanediol, 1,12-dodecanediol, 1,2,10-decanetriol, 2-methylpentane-2,4-diol, 2-ethyl-1,3-hexanediol, 3-(2-ethylhexyloxy)-1,2-propanediol, and polyethylene glycol, and more preferably dipropylene glycol, 1, The alkyl group is at least one selected from the group consisting of 2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2,10-decanetriol, 2-ethyl-1,3-hexanediol, and 3-(2-ethylhexyloxy)-1,2-propanediol, more preferably at least one selected from the group consisting of dipropylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 2-ethyl-1,3-hexanediol, and 3-(2-ethylhexyloxy)-1,2-propanediol, even more preferably at least one selected from the group consisting of dipropylene glycol and 3-(2-ethylhexyloxy)-1,2-propanediol, and even more preferably dipropylene glycol.

[0065] When the composition of the present invention contains component (H), the content thereof is, from the viewpoints of disinfection durability and hand roughness inhibition effect, 2.5% by mass or more, preferably 2.7% by mass or more, more preferably 2.8% by mass or more, even more preferably 2.9% by mass or more, even more preferably 3.0% by mass or more, even more preferably 3.1% by mass or more, and is 10% by mass or less, preferably 9% by mass or less, more preferably 8% by mass or less, and even more preferably 7% by mass or less.

[0066] The composition of the present invention may contain a polyol other than the component (H), that is, a component (H') having a (number of OH groups / number of C atoms) of 1 or more (for example, glycerin). When component (H') with a ratio (number of OH groups / number of C atoms) of 1 or more is contained, the content thereof is, from the viewpoint of improving the bactericidal activity and its sustained effect, preferably 30 parts by mass or less, more preferably 25 parts by mass or less, even more preferably 20 parts by mass or less, and even more preferably 16 parts by mass or less, per 100 parts by mass of component (H).

[0067] The mass ratio of polyol (h-1) to polyol (h-2) [(h-1) / (h-2)] is, from the viewpoint of reducing irritation to the skin and suppressing rough hands, and from the viewpoint of suppressing volatilization of polyol (h-2), which is a bactericidal component, preferably 0.01 or more, more preferably 0.03 or more, even more preferably 0.05 or more, still more preferably 0.08 or more, and is preferably 3.0 or less, more preferably 2.5 or less, even more preferably 2.0 or less, and still more preferably 1.5 or less.

[0068] <Component (I)> Component (I) includes one or more acids selected from the group consisting of lactic acid, pyruvic acid, and urocanic acid, or salts thereof. Examples of salts of lactic acid, pyruvic acid, and urocanic acid include alkali metal salts such as potassium salts and sodium salts of lactic acid, pyruvic acid, and urocanic acid, alkaline earth metal salts such as calcium salts and magnesium salts, amine salts, ammonium salts, etc. Among these, from the viewpoint of improving the bactericidal activity and its sustained effect, and from the viewpoint of reducing irritation to the skin and suppressing rough hands, one or more selected from the group consisting of alkali metal salts and alkaline earth metal salts of lactic acid, pyruvic acid, and urocanic acid are preferred, one or more selected from the group consisting of potassium salts, sodium salts, and calcium salts of lactic acid, pyruvic acid, and urocanic acid are more preferred, and one or more selected from the group consisting of potassium lactate, sodium lactate, and calcium lactate are even more preferred.

[0069] As component (I), from the viewpoint of improving the bactericidal activity and its sustained effect, and from the viewpoint of reducing irritation to the skin and suppressing rough hands, one or more selected from the group consisting of lactic acid and its salts are preferable, one or more selected from the group consisting of lactic acid, potassium lactate, sodium lactate, and calcium lactate are more preferable, one or more selected from lactic acid and sodium lactate are even more preferable, and lactic acid and sodium lactate are even more preferable.

[0070] When the composition of the present invention contains component (I), the content thereof is, from the viewpoint of improving the bactericidal activity and its sustained effect, 0.10 mass% or more, preferably 0.3 mass% or more, more preferably 0.5 mass% or more, even more preferably 0.7 mass% or more, still more preferably 0.9 mass% or more, and is 2.0 mass% or less, preferably 1.9 mass% or less, more preferably 1.8 mass% or less, even more preferably 1.7 mass% or less, still more preferably 1.6 mass% or less, and still more preferably 1.5 mass% or less.

[0071] When lactic acid and a salt thereof are used in combination, the lactic acid / salt thereof (mass ratio) is preferably 0.1 or more, more preferably 2.5 or more, even more preferably 0.4 or more, still more preferably 0.6 or more, still more preferably 0.8 or more, still more preferably 1.5 or more, and is preferably 20 or less, more preferably 15 or less, still more preferably 10 or less, still more preferably 8 or less, and still more preferably 6 or less, from the viewpoints of improving bactericidal activity and its sustained effect, and of reducing irritation to the skin and suppressing rough hands.

[0072] The total content of lactic acid and its salts in the total amount of component (I) is preferably 80% by mass or more, more preferably 90% by mass or more, even more preferably 95% by mass or more, and even more preferably 100% by mass, from the viewpoints of improving bactericidal activity and its sustained effect, and of reducing irritation to the skin and suppressing rough hands.

[0073] <Ingredients (J)> Component (J) is a bactericide other than an alcohol-based bactericide, and examples thereof include one or more selected from the group consisting of cationic bactericides, iodine-based bactericides, phenol-based bactericides, biguanide-based bactericides, terpenoid-based bactericides, chlorine-based bactericides, and amphoteric surfactant-based bactericides.

[0074] Examples of cationic disinfectants include quaternary ammonium salt compounds such as alkylpyridinium salts having an alkyl group with 8 to 18 carbon atoms, such as cetylpyridinium chloride, benzethonium salts such as benzethonium chloride, alkylbenzyldimethylammonium salts (benzalkonium chloride) having an alkyl group with 8 to 18 carbon atoms, and dialkyldimethylammonium salts having an alkyl group with 8 to 12 carbon atoms, such as didecyldimethylammonium chloride. Examples of the salts include chloride salts, methyl sulfates, and ethyl sulfates, with chloride salts being preferred. Examples of iodine-based disinfectants include povidone iodine, polyvinyl alcohol iodine, and cyclodextrin iodine. Phenol-based disinfectants include isopropylmethylphenol, triclosan, and phenoxyethanol. Biguanide disinfectants include chlorhexidine gluconate. Terpenoid fungicides include dipotassium glycyrrhizinate, stearyl glycyrrhetinate, and β-glycyrrhetinic acid. Examples of chlorine-based disinfectants include hypochlorous acid, sodium hypochlorite, calcium hypochlorite, and chlorinated isocyanuric acid. Examples of amphoteric surfactant-based bactericides include alkyldiaminoethylglycine hydrochloride and alkylpolyaminoethylglycine.

[0075] The component (J) can be used alone or in combination of two or more. Among the above, from the viewpoint of improving the bactericidal activity and its sustained effect, and from the viewpoint of reducing irritation to the skin and suppressing rough hands, component (J) is preferably one or more selected from the group consisting of cationic bactericides, iodine-based bactericides, phenol-based bactericides, and biguanide-based bactericides, and more preferably one or more selected from the group consisting of cationic bactericides, iodine-based bactericides, and biguanide-based bactericides. Among these, more preferred is one or more selected from the group consisting of benzalkonium chloride, benzethonium chloride, povidone iodine, and chlorhexidine gluconate, and even more preferred is benzalkonium chloride having an alkyl group with 8 to 16 carbon atoms.

[0076] When the composition of the present invention contains component (J), the content thereof is, from the viewpoints of the durability of bactericidal activity and the effect of inhibiting rough hands, preferably 0.01% by mass or more, more preferably 0.02% by mass or more, even more preferably 0.03% by mass or more, still more preferably 0.04% by mass or more, and is preferably 2.0% by mass or less, more preferably 1.5% by mass or less, even more preferably 1.0% by mass or less, still more preferably 0.5% by mass or less, still more preferably 0.3% by mass or less, and still more preferably 0.1% by mass or less.

[0077] <Ingredients (K)> Component (K) is an oily feel improver, and examples thereof include ester-based oils such as medium-chain fatty acid triglycerides and isopropyl myristate, hydrocarbon-based oils such as isododecane, hydrogenated polyisobutene, squalane, squalene, and liquid paraffin, and silicone-based oils such as cyclopentasiloxane, methylpolysiloxane, and dimethicone. When the composition of the present invention contains component (K), the content thereof is preferably 0.001 mass% or more, more preferably 0.008 mass% or more, even more preferably 0.01 mass% or more, and is preferably 5 mass% or less, more preferably 3 mass% or less, even more preferably 1 mass% or less.

[0078] <Ingredients (L)> Component (L) is a skin protective agent, examples of which include glycyrrhetinic acid, nicotinamide, ceramide, pseudoceramide, allantoin, hyaluronate, urea, tocopherol acetate, and dipotassium glycyrrhizinate. When the composition of the present invention contains component (L), the content thereof is preferably 0.001 mass% or more, more preferably 0.008 mass% or more, even more preferably 0.01 mass% or more, and is preferably 5 mass% or less, more preferably 3 mass% or less, even more preferably 1 mass% or less.

[0079] The composition of the present invention may further contain other components, such as ultraviolet absorbers, antioxidants, preservatives, antiperspirants, fragrances, moisturizers (excluding components (H) and (L)), and anti-inflammatory agents.

[0080] <Water> The composition of the present invention in the first or second embodiment contains water from the viewpoint of dissolving or dispersing component (A) and component (B) and from the viewpoint of facilitating application to targets on the skin surface such as fingers. The water content in the composition of the present invention is preferably 10% by mass or more, more preferably 15% by mass or more, even more preferably 20% by mass or more, even more preferably 25% by mass or more, and is preferably 60% by mass or less, more preferably 55% by mass or less, even more preferably 50% by mass or less, and even more preferably 45% by mass or less. The content of water in the composition of the present invention may be the balance of the components (A) to (L).

[0081] <Viscosity> The viscosity of the composition of the present invention in the first embodiment at 25° C. is preferably 10 mPa·s or more and 10,000 mPa·s or less, from the viewpoint of ease of spreading on the skin. The viscosity of the composition of the present invention according to the second embodiment at 25° C. is from 10 mPa·s to 10,000 mPa·s inclusive, from the viewpoint of ease of spreading on the skin. The viscosity at 25°C of the composition of the present invention in the first or second embodiment is preferably 30 mPa·s or more, more preferably 50 mPa·s or more, even more preferably 100 mPa·s or more, even more preferably 500 mPa·s or more, even more preferably 1,000 mPa·s or more, even more preferably 1,500 mPa·s or more, even more preferably 2,000 mPa·s or more, and is preferably 10,000 mPa·s or less, more preferably 8,000 mPa·s or less, even more preferably 5,000 mPa·s or less, even more preferably 4,000 mPa·s or less, and even more preferably 3,000 mPa·s or less. The viscosity of the composition of the present invention at 25° C. can be specifically measured by the method described in the Examples. EXAMPLES

[0082] The present invention will be described below with reference to examples, but the present invention is not limited to the scope of the examples. In the examples, various measurements and evaluations were carried out by the following methods.

[0083] (viscosity) The viscosity at 25° C. of the composition obtained in each example was measured using a Brookfield viscometer (TVB-10M, manufactured by Toki Sangyo Co., Ltd.) at 25° C. under the following conditions according to the target viscosity. This measurement was performed three times, and the average results are shown in Table 1. <Measurement conditions> ·Viscosity: 1~10mPa·s Fixture L / Adp, rotation speed 60 rpm ·Viscosity: 10~100mPa·s Jig M1, rotation speed 60 rpm ·Viscosity over 100mPa·s and below 1,000mPa·s Jig M2, rotation speed 30 rpm ·Viscosity over 1,000mPa·s and below 10,000mPa·s Jig M3, rotation speed 12 rpm ·Viscosity over 10,000mPa·s and below 100,000mPa·s Jig M4, rotation speed 6 rpm

[0084] (tack strength) The composition obtained in each example was used as a measurement sample, and 0.8 g of the measurement sample was subjected to a tack test at 0.05 g / cm using a tack tester (Rhesca "TAC-1000"). 2 For the pigskin surface that was coated with 2 A stainless steel probe having a flat circular surface at the tip was pressed against the composition at a pressing load of 150 gf at a speed of 2 mm / s for 1 second, and then the probe was pulled up at a speed of 0.5 mm / s to a distance of 5 mm from the position before the probe was pressed (on the pigskin surface), and the tack force F (gf) was measured. The tack force was measured every minute until the tack force reached 0 gf. The measurement results of the tack force of the composition obtained in Example 4 are shown in Figure 1. Here, the tack force of the first measurement is F1, and the maximum tack force among the tack forces obtained by the end of the measurement is F max It was decided. The difference in tack force ΔF was calculated from the following formula and is shown in Table 1. Difference in tack force ΔF(gf) = (maximum tack force F max (gf))-(First measurement tack force F1(gf))

[0085] (Sticky suppression effect due to difference in tackiness ΔF) For the compositions obtained in each example, the stickiness suppressing effect based on the difference in tackiness ΔF was evaluated according to the following criteria. The results are shown in Table 1. A: When the difference Δ in tack strength was 3.1 or less, it was evaluated that the stickiness suppression effect was high. B: When the difference Δ in tack strength was greater than 3.1 and not more than 5, the stickiness suppression effect was evaluated as being satisfactory at a practical level. C: When the difference Δ in tack strength was more than 5, the stickiness suppression effect was evaluated as low.

[0086] (Sensory test shows stickiness suppression effect) The compositions obtained in each example were subjected to a sensory test by a panel of experts, and the stickiness suppressing effect was evaluated according to the following criteria. The results are shown in Table 1. A: If almost no stickiness was felt, the stickiness suppression effect was evaluated as being high. B: If stickiness was felt slightly but within the tolerable range, it was evaluated that the stickiness suppression effect was at a practical level and did not pose a problem. C: If stickiness was felt, the stickiness suppression effect was evaluated as low.

[0087] Examples 1 to 5, Comparative Examples 1 to 5 The liquid skin topical composition was prepared by mixing the components in the amounts shown in Table 1 at room temperature. The amounts shown in Table 1 are the active ingredient amounts (mass %) of each component.

[0088] [Table 1]

[0089] The ingredients listed in Table 1 are as follows, and the amounts listed in Table 1 are the active ingredients. <Component (A)> a-1 Carboxyvinyl polymer: "Carbopol 980NF" manufactured by Lubrizol Advanced Materials Inc. a-2 Hydroxypropyl cellulose: "HPC-H" manufactured by Nippon Soda Co., Ltd., weight average molecular weight 1 million, viscosity 1000-4000 mPa·s [20℃ / 2% aqueous solution] <Ingredient (B)> b-1 Polyethylene glycol: "Macrogol 6000" manufactured by Sanyo Chemical Industries, Ltd., number average molecular weight (Mn) 8,600 b-2 Polyethylene glycol: "PEG-1540" manufactured by Sanyo Chemical Industries, Ltd., number average molecular weight (Mn) 1,500 <Ingredient (C)> c-1 Ethanol: "Fermented alcohol 95% Grade 1" manufactured by Godo Shusei Co., Ltd. <Ingredient (D)> d-1 Polyoxyethylene (3) lauryl ether: Kao Corporation's "Emulgen 103KG", HLB 8.3, average EO added mole number 3 d-2 Polyoxyethylene (21) lauryl ether: Kao Corporation's "Emulgen 121-G", HLB 16.6, average EO molar addition number 21 <Ingredient (E)> e-1 N-(tetradecyloxyhydroxypropyl)-N-hydroxyethyldecanoamide: Kao Corporation "Pharmaceutical grade SL-E40" <Component (F)> f-1 Triethanolamine: "Triethanolamine-S" manufactured by Okura Chemitech Co., Ltd. <Ingredients (G)> g-1 Talc: "Crown Talc Official PP" manufactured by Matsumura Sangyo Co., Ltd. <Component (H)> h-1 1,3-Butylene glycol: "1,3-Butylene glycol-P" manufactured by KH Neochem Co., Ltd. h-2 Dipropylene glycol: ADEKA Corporation "DPG-RF" <Component (I)> i-1 Lactic acid: Musashino Chemical Laboratory Co., Ltd. "Musashino Lactic Acid 90" i-2 Sodium lactate: Musashino Chemical Laboratory Co., Ltd. "Sodium lactate solution 50%" <Ingredients (J)> j-1 Benzalkonium chloride: "Sanisol C" manufactured by Kao Corporation, linear alkylbenzyldimethylammonium chloride with an alkyl group having 8 to 16 carbon atoms <Ingredients (K)> k-1 Medium-chain triglyceride: Kao Corporation's "Coconard MT", a triester of fatty acids with 8 to 10 carbon atoms and glycerin <Ingredients (L)> l-1 Glycyrrhetinic acid: "Glycyrrhetinic acid" manufactured by Alps Pharmaceutical Co., Ltd. <Other ingredients> Glycerin: Kao Corporation's "Glycerin Act" Isopropyl palmitate: "Excepearl IPP" manufactured by Kao Corporation Glycerol monoisodecyl ether: "Venetol GE-IS" manufactured by Kao Corporation

[0090] From the results shown in Table 1, the following was confirmed: It was confirmed that in Examples 1 to 5, liquid skin external preparation compositions having bactericidal properties and excellent effects of suppressing stickiness on the skin could be obtained. On the other hand, in Comparative Examples 1 to 5, although they had bactericidal properties, they were all rated as "C" in the evaluation of the stickiness suppression effect, and it was confirmed that they were inferior to Examples 1 to 5 in the stickiness suppression effect. [Industrial Applicability]

[0091] According to the present invention, it is possible to provide a liquid composition for external use on the skin that has excellent bactericidal properties and is also excellent in preventing stickiness on the skin.

Claims

1. A liquid skin topical composition thickened with a polymer, comprising: at least two polymers having hydrogen bonding interactions, ethanol and / or isopropanol (component (C)), and water; A liquid skin topical preparation composition, in which the difference ΔF in tack strength measured by the method described below, calculated by the formula described below, is 5.0 gf or less. Tack force difference ΔF (gf) = (maximum tack force F max (gf) - (First measurement tack force F 1 (gf) <Measurement of tack strength> Using a tack tester (Rhesca "TAC-1000"), 0.8 g of the measurement sample was applied with a tack of 0.05 g / cm ２ For the pigskin surface coated with ２ A stainless steel probe having a flat circular surface at its tip was pressed against the skin at a speed of 2 mm / s with a pressing load of 150 gf for 1 second, and then the probe was pulled up at a speed of 0.5 mm / s to a distance of 5 mm from the position before the probe was pressed (on the surface of the pigskin), and the tack force F (gf) was measured. The measurement of the tack force was carried out every minute until the tack force reached 0 gf. Here, the tack force of the first measurement is F 1 The maximum tack strength obtained by the end of the measurement is F max It was decided.

2. the at least two polymers having hydrogen bonding interactions are a thickening polymer (component (A)) and a nonionic polymer (component (B)) capable of forming a hydrogen bond with component (A); 2. The liquid skin topical preparation composition according to claim 1, wherein the total content of component (A) and component (B) is 0.2% by mass or more and 1.0% by mass or less, the mass ratio of component (B) to component (A) [(B) / (A)] is 0.3 or more and 1.0 or less, and the viscosity at 25°C is 10 mPa·s or more and 10,000 mPa·s or less.

3. The present invention comprises a thickening polymer (component (A)), a nonionic polymer capable of forming a hydrogen bond with component (A) (component (B)), ethanol and / or isopropanol (component (C)), and water, A liquid skin topical preparation composition, the total content of component (A) and component (B) being 0.2% by mass or more and 1.0% by mass or less, the mass ratio of component (B) to component (A) [(B) / (A)] being 0.3 or more and 1.0 or less, and the viscosity at 25°C being 10 mPa·s or more and 10,000 mPa·s or less.

4. The liquid skin topical composition according to claim 1 or 3, wherein the content of component (C) is 40% by mass or more and 90% by mass or less.

5. The liquid skin external preparation composition according to any one of claims 2 to 4, wherein the total content of component (A) and component (B) is 0.5% by mass or more.

6. Further, the composition contains a nonionic surfactant (component (D)) having a lipophilic group having from 12 to 18 carbon atoms and an HLB (hydrophilic-lipophilic balance) of from 8.0 to 17.0, The liquid skin external preparation composition according to any one of claims 2 to 5, wherein the content of component (D) is 0.01% by mass or more and 2.0% by mass or less.

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