Application device and installation base of experimental animal retention device

Abstract

To provide means capable of changing a size of a body part so as to correspond to an individual difference of experimental animals, and provide means that relaxes stress on an experimental animal.SOLUTION: An experimental animal retention device includes: a retention device body part including right and left opening parts and a top face cutout part; a head part storage part that stores a head part of an experimental animal; and a tail part pressing part provided with a window part capable of pressing a tail part of the experimental animal and extracting the tail part. The experimental animal retention device is a cylindrical body, has cutout parts in the right and left opening parts and the top face, and can be attached to and detached from the inside of the body part.SELECTED DRAWING: Figure 1

Description

Detailed Description of the Invention [Technical field]

[0001] The present invention relates to an applicator and a mounting stand for use in a laboratory animal restraint device for restraining laboratory animals such as mice and rats. [Background technology]

[0002] Animal experiments such as drug administration and blood sampling are conducted using the tails of mice, rats, and other animals, but during these experiments the animals must be restrained so as not to move.

[0003] For example, JP 2019-71974 A discloses a technology relating to a restraining device for experimental animals, which comprises a main body having a through-hole and a gap, a head storage section for storing the head of an experimental animal by moving the inside of the through-hole parallel to the longitudinal direction of the main body, a knob section for operating the head storage section and fixing it to the main body, and a barrier section having a slit, wherein the barrier section is removable from the main body or is attached to the main body in an openable / closable manner, and when the barrier section is attached to the main body, the slit is provided starting from the edge side of the main body located on the base side.

[0004] On the other hand, experimental animals such as mice and rats have individual differences and are not always the same size. If the size of the main body into which the experimental animal is inserted, i.e., the inner diameter, is constant, there are problems such as the experimental animal having difficulty entering, or moving around due to space limitations. Furthermore, it is expected that this may have a negative impact on the psychological state of the experimental animal. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] JP 2019-071974 A Summary of the Invention [Problem to be solved by the invention]

[0006] The present invention is intended to solve the above-mentioned problems, and aims to provide a means for changing the size of the main body to accommodate individual differences in experimental animals, and to provide a means for reducing stress in experimental animals. [Means for solving the problem]

[0007] The present invention is characterized in that the experimental animal restraint device has a restraint device main body having left and right openings and a notch on the top surface, a head storage section for storing the head of the experimental animal, and a tail holding section for holding the experimental animal's buttocks and having a window through which the tail can be extracted, and is an applicator that is cylindrical, has left and right openings and a notch on the top surface, and can be attached and detached into the main body.

[0008] Further, the applicator is characterized in that it is translucent red in color and that the opening of the cylindrical body is tapered.

[0009] This is an installation base for a laboratory animal restraint device, characterized in that it is a fixation base for fixing the main body, and is equipped with a groove for fixing the base of the main body at a vertical tilt, and a tail fixation base for placing the tail of the laboratory animal. Effect of the Invention

[0010] By using the applicator of the present invention, it is possible to select an appropriate size for individual differences in the experimental animals, and it is possible to reduce the stress of the experimental animals. Furthermore, the applicator is a transparent red color, which makes it possible to stabilize the mental state of the experimental animals. In addition, by providing a taper at the end of the cylindrical body, it is possible to easily insert the experimental items and reduce stress.

[0011] By using the installation stand of the present invention, the experimental animal restrainer can be laid vertically and the tail side of the experimental animal can be directed to the ceiling. When blood is collected from the tail of an experimental animal, it is common to do so from the side of the tail. This is because blood vessels are concentrated near the side of the tail. Therefore, if a conventional experimental animal restrainer is not laid horizontally, it is necessary to twist the tail to direct the side to the ceiling, which results in excessive stress on the experimental animal. By using this installation stand, the tail of the experimental animal does not need to be twisted, making it possible to avoid stress on the experimental animal. [Brief description of the drawings]

[0012] [Figure 1] FIG. 1 is a perspective view showing an overall configuration of the present invention. [Diagram 2] FIG. 2 is a side view of an applicator of the present invention. [Diagram 3] FIG. 2 is a perspective view of the restraint device installation stand of the present invention. [Figure 4] FIG. 2 is a side view of the restraint device installation stand with the restraint device body placed on it. [Diagram 5] FIG. 1 is a perspective view of a conventional laboratory animal restraint device. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0013] Hereinafter, the applicator and the installation stand of the laboratory animal restraint device of the present invention will be described with reference to the drawings. EXAMPLES

[0014] Fig. 5 is a diagram showing an example of a conventional restraining device for laboratory animals. Fig. 1 is a perspective view showing the overall configuration of the present invention. It is composed of a restraining device main body 2, a tail holding part 3, a head storage part 4, and an applicator 5. The restraining device main body 2 may be placed on a base 7. The restraining device main body 2 is cylindrical and has a through space inside for the laboratory animal to enter, and a cutout part 8 is provided on the top surface. The cutout part 8 is for fixing the head storage part 4 so that it can be moved. Both end faces of the restraining device main body 2 are provided with tapered openings 6, and both ends of the opening 6 are provided with protruding parts 9 into which the tail holding part 3 is inserted. The restraint device body 2 is preferably made of a material such as transparent or semi-transparent so that the experimental animal can see it, but is not limited to this. In addition, the restraint device body 2 is preferably made of resin, but is not limited to glass or other resins.

[0015] The head storage section 4 is intended to prevent the experimental animal from slipping out of the restraint body 2 or the applicator 5 described below. The head storage section 4 is approximately hemispherical, and is provided with a clamping section from the inside of the body and a fixing section using a screw or the like from the outside of the body, for insertion and fixing into the notches 8 and 11 (not shown). The fixing position can be changed within the longitudinal range of the notches 8 and 11. After the procedure, the experimental animal can be taken out of the restraint body 2 by removing the head storage section 4, making it possible to carry out the procedure without going against the animal's habits.

[0016] The tail holding part 3 is rectangular and has a vertically long window 10 in the center for passing the experimental animal's tail 17 through. Although not shown, grooves are provided on both the left and right ends so that they can fit into the protruding parts 9 of the restraint device main body 2. This makes it possible to attach and detach the restraint device main body 2.

[0017] The applicator 5 is a cylinder having a through space inside which the laboratory animal can be placed, and has a notch 11 on the top surface. The notch 11 is for fixing the head storage section 4 so that it can be moved. It is desirable to provide a tapered opening 6 on one end surface of the applicator 5. This is to make it easier for the laboratory animal to enter both physically and psychologically. It also functions as a stopper when attached to the restraint device main body 2. Figure 2 is a side view of the applicator of the present invention.

[0018] A plurality of applicators 5 can be prepared with different inner diameters. This is to accommodate the fact that even the same mouse or rat may have different physical characteristics due to individual differences. Furthermore, this also contributes to improving the convenience of the user. EXAMPLES

[0019] The applicator 5 may be a translucent red color. Instead of the applicator 5, the restraint body 2 may be a translucent red color. Furthermore, the applicator 5 and the restraint body 2 may be a translucent red color. The color red is a color that stabilizes the mental state of experimental animals. In our experiments, we confirmed that when the restraint body 2 or the applicator 5 was a translucent red color, the experimental animals were able to enter obediently and remained calm after entering, compared to transparent or non-transparent materials. EXAMPLES

[0020] When taking blood samples from the tails of experimental animals, it is common to do so from the side of the tail. This is because blood vessels are concentrated near the side of the tail. Therefore, the current practice is to twist the tail so that the side faces the ceiling, which results in excessive stress for the experimental animals.

[0021] In order to perform blood sampling etc. without twisting the experimental animal's tail, the experimental animal restraint device can be placed vertically on its side. The installation stand 12 is for fixing the restraint device main body 2 in a vertically tilted position. The base 13 is provided with a roughly rectangular main body fixing part 14 on which the restraint device main body 2 is placed, and a rectangular tail fixing stand 15 on which the experimental animal's tail 17 is placed. A groove 16 may be provided into which the base 7 on which the restraint device main body 2 is placed can be inserted vertically. By tilting the restraint device main body 2 by 90 degrees, the tail side of the experimental animal inside the restraint device main body 2 can be directed toward the ceiling.

[0022] The top surface of the main body fixing part 14 may be provided with an arc-shaped recess. The restraint device main body 2 placed on the main body fixing part 14 becomes more stable. The installation base 12 is preferably made of resin, but is not limited to this. Figure 3 is a perspective view of the restraint device installation base of the present invention, and Figure 4 is a side view of the restraint device installation base with the restraint device main body placed on it. [Industrial Applicability]

[0023] The applicator for the laboratory animal restraint device of the present invention and its installation stand can be industrially produced. [Explanation of symbols]

[0024] 1: Restraint device for laboratory animals; 2: Restraint device body; 3: Tail holding section; 4: Head storage section; 5: Applicator; 6: Opening section; 7: Base; 8: Cutout section; 9: Protruding section; 10: Window section; 11: Cutout section; 12: Installation stand; 13: Base; 14: Main body fixing section; 15: Tail fixing stand; 16: Groove section; 17: Tail

Claims

1. An adaptor for an experimental animal restraint device having a restraint body having left and right openings and a notch on the top surface, a head storage section for storing the head of the experimental animal, and a tail holding section for holding the experimental animal's buttocks and having a window through which the tail can pass, the adaptor is a cylindrical body having left and right openings and notches on the top surface and is detachable from the restraint body.

2. 2. An adaptor for a laboratory animal restraint device according to claim 1, characterized in that one opening of said cylindrical body is tapered.

3. 3. An adaptor for a restraint device for laboratory animals according to claim 1 or 2, characterized in that the restraint device body or the cylindrical body is a translucent red color.

4. This is a stand for fixing an experimental animal restraint device at a vertical incline, characterized in that it is provided with a main body fixing part for placing the restraint device main body thereon, and a tail fixing stand for placing the experimental animal's tail.

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