Oil-in-water emulsion composition

Abstract

To provide an oil-in-water emulsion composition having superior usability and stability.SOLUTION: An oil-in-water emulsion composition contains alkyl glycoside, polyglyceryl fatty acid ester, and an anionic surfactant.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an oil-in-water emulsion composition. [Background technology]

[0002] One type of formulation for topical skin preparations, such as lotions and creams, is the oil-in-water emulsion type. In general, oil-in-water emulsion compositions are preferred because they provide a fresh, light feel when used. For application as a skin topical agent, the stability of the emulsion system is important. For example, it has been disclosed that a finer emulsion can be produced by using a combination of specific surfactants for emulsification, thereby producing an oil-in-water emulsion composition that is excellent in stability over time and temperature and in usability (Patent Document 1). Furthermore, Patent Document 2 discloses an oil-in-water emulsion composition that uses a specific quantitative combination of an alkyl glycoside, a polyglycerol fatty acid ester, and a phospholipid as surfactants for emulsification, thereby enabling various active ingredients to penetrate well into the stratum corneum. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Patent No. 6031182 [Patent Document 2] Patent Publication No. 2021-187804 Summary of the Invention [Problem to be solved by the invention]

[0004] An object of the present invention is to provide an oil-in-water emulsion composition that is excellent in usability and stability. [Means for solving the problem]

[0005] As a result of intensive research into solving the above problems, the inventors discovered that the above problems could be solved by combining an alkyl glycoside, a polyglycerol fatty acid ester, and an anionic surfactant, and thus completed the present invention.

[0006] That is, the present invention is as follows. [1] An oil-in-water emulsion composition comprising the following (A) to (C): (A) Alkyl glycoside (B) Polyglycerol fatty acid ester (C) Anionic surfactants [2] The oil-in-water emulsion composition according to [1], wherein the component (A) is an alkyl glycoside represented by the following general formula (1):

[0007] [ka] (In the formula, N represents an integer of 2 to 7, R independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, and n represents an integer of 1 to 4.)

[0008] [3] The oil-in-water emulsion composition according to [1] or [2], wherein the content of the component (A) is 0.01 to 10% by weight based on the total weight of the composition. [4] The oil-in-water emulsion composition according to any one of [1] to [3], wherein component (B) is a polyglycerol fatty acid ester obtained by ester condensation of one molecule of polyglycerol having a degree of polymerization of 2 to 10 with 2 to 5 molecules of a fatty acid having 16 or more carbon atoms. [5] The oil-in-water emulsion composition according to any one of [1] to [4], wherein the content of component (B) is 0.05 to 10% by weight based on the total weight of the composition. [6] The oil-in-water emulsion composition according to any one of [1] to [5], wherein the component (C) has an HLB value of 9 or more. [7] The oil-in-water emulsion composition according to any one of [1] to [6], wherein the component (C) is one or more anionic surfactants selected from acyl lactate salts and fatty acid glyceryl sulfate salts. [8] The oil-in-water emulsion composition according to any one of [1] to [7], wherein the content of the component (C) is 0.05 to 5% by weight based on the total weight of the composition. [9] The oil-in-water emulsion composition according to any one of [1] to [8], further comprising a component (D) higher alcohol.

[10] The oil-in-water emulsion composition according to [9], wherein the component (D) is 0.05 to 5% by weight based on the total weight of the composition.

[11] The oil-in-water emulsion composition according to any one of [1] to

[10] , wherein the weight ratio (A) / ((B)+(C)) of the content of component (A) to the total content of components (B) and (C) in the composition is 0.005 to 50.

[12] The oil-in-water emulsion composition according to any one of [1] to

[11] , which is an external preparation for skin. Effect of the Invention

[0009] According to the present invention, a stable oil-in-water emulsion composition can be prepared. The composition of the present invention also provides excellent effects such as good usability, specifically good spreadability and ease of application, and increased moisture content and improved softness on the skin after application. Therefore, the composition of the present invention is suitable for use as a skin external preparation such as a cosmetic. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] The oil-in-water emulsion composition of the present invention contains (A) an alkyl glycoside, (B) a polyglycerol fatty acid ester, and (C) an anionic surfactant.

[0011] The alkyl glycoside (A) in the present invention cooperates with the other surfactants (B) and (C) to realize a highly stable emulsion system, and also contributes to a good feel when used, particularly to an increase in the moisture content of the stratum corneum of the skin to which the composition is applied.

[0012] The (A) alkyl glycoside in the present invention is a compound in which an aliphatic alcohol is bound to a sugar via a glycosidic bond, and has a hydrocarbon chain and a sugar residue. The hydrocarbon chain constituting the alkyl glycoside may be either linear or branched, and may be either saturated or unsaturated, but is preferably a linear or branched saturated hydrocarbon. The number of carbon atoms in the hydrocarbon chain is not particularly limited, but is preferably, for example, 8 to 35, more preferably 10 to 22, further preferably 12 to 20, and particularly preferably 12 to 16.

[0013] The sugar residue constituting the alkyl glycoside may be any of monosaccharides, oligosaccharides, and polysaccharides. The degree of sugar condensation (i.e., the number of monosaccharides constituting the sugar residue) can be, for example, 1 to 5. 10 is preferred, 1 to 5 is more preferred, and 2 to 3 is even more preferred. Specific examples of the sugar residue include monosaccharides such as glucose, galactose, xylose, mannose, lyxose, arabinose, and fructose; oligosaccharides or polysaccharides such as maltose, xylobiose, isomaltose, cellobiose, lactose, gentiobiose, maltotriose, isomaltotriose, cellotriose, maltotetraose, maltopentaose, maltohexaose, maltoheptaose, isomaltotetraose, isomaltopentaose, isomaltohexaose, and isomaltoheptase; and the like. Among these, preferred are monosaccharides, disaccharides, and trisaccharides. More preferred are glucose, galactose, maltose, and maltotriose.

[0014] The alkyl glycoside in the present invention is more preferably an alkyl glycoside represented by the following general formula (1).

[0015] [ka]

[0016] In general formula (1), N represents an integer of 2 to 7. R independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, and preferably represents a methyl group. n represents an integer of 1 to 4, and preferably represents 2 or 3, and more preferably represents 2. In other words, the alkyl glycoside represented by general formula (1) has a structure in which the hydroxyl group at the 1-position of the terminal sugar of the oligosaccharide is bonded (condensed) with an aliphatic alcohol. The aliphatic alcohol is preferably an aliphatic alcohol having 12 to 20 carbon atoms, more preferably 12 to 16 carbon atoms, and even more preferably 15 carbon atoms, which may be branched.

[0017] The sugar residue in the alkyl glycoside represented by the general formula (1) is the hydrophilic part. Sugar residues include maltose, maltotriose, maltotetraose, maltopentaose, maltohexaose, and maltoheptaose, with maltose and maltotriose being more preferred.

[0018] In general formula (1), the fatty chain is the hydrophobic portion of the alkyl glycoside of the present invention. The aliphatic chain portion may or may not have a branched chain, but preferably has a branched chain. That is, in general formula (1), R independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, preferably an alkyl group having 1 to 3 carbon atoms, and more preferably a methyl group.

[0019] As the alkyl glycoside according to the present invention, a compound represented by the following general formula (2) is more preferable.

[0020] [ka]

[0021] In formula (2), N represents an integer of 2 to 7. n represents an integer of 1 to 4, more preferably 2 or 3, and further preferably 2. Examples of compounds encompassed by general formula (2) include, but are not limited to, Mal2Far (a glycoside of maltose and hexahydrofarnesol), Mal3Far (a glycoside of maltotriose and hexahydrofarnesol), and Mal3Phyt (a glycoside of maltotriose and hexahydrophytol).

[0022] The alkyl glycosides according to the present invention can be obtained by various well-known methods, such as glycosylation methods using sugar bromides, glycosylation methods using sugar fluorides, glycosylation methods using trichloroacetimidates, and glycosylation methods using acetylated sugars. More specifically, examples of the synthesis processes include those described in Japanese Patent Nos. 3882067, 4817435, and 5207420, as well as Japanese Patent Publication Nos. 2013-129660 and 2012-17318.

[0023] The content of the (A) alkyl glycoside in the oil-in-water emulsion composition of the present invention is preferably 0.01 to 10 wt %, more preferably 0.03 to 5 wt %, and even more preferably 0.05 to 2 wt %, based on the total weight of the composition. By using the composition in this range, the emulsion system becomes more stable, the composition spreads easily when applied to the skin, and the skin after application has an increased moisture content and improved softness, making it easier to obtain an excellent feel when used.

[0024] The polyglycerol fatty acid ester (B) in the present invention cooperates with the other surfactants (A) and (C) to realize a highly stable emulsion system and also contributes to a good feel when used.

[0025] Component (B) is not particularly limited, but the degree of polymerization of polyglycerin in the polyglycerin portion is preferably 2 to 10, more preferably 6 to 10, and even more preferably 10. The fatty acid in the fatty acid portion preferably has 16 to 24 carbon atoms, more preferably 16 to 20, and even more preferably 16 to 18. One molecule of polyglycerin is preferably formed by ester bonding with 2 to 5 fatty acid molecules. Particularly preferred examples of component (B) include polyglycerin fatty acid esters formed by ester condensation of one molecule of polyglycerin having a degree of polymerization of 2 to 10 with 2 to 5 fatty acid molecules having 16 or more carbon atoms. Moreover, the component (B) preferably has an HLB value of 2-15. In this specification, HLB is calculated by Griffin's formula.

[0026] Specific examples of component (B) include polyglyceryl-10 tristearate (HLB: 3), polyglyceryl-2 stearate (HLB: 5.5), polyglyceryl-4 pentastearate (HLB: 2.6), polyglyceryl-5 pentastearate (HLB: 4), polyglyceryl-6 pentastearate (HLB: 6), polyglyceryl-10 pentastearate (HLB: 3.5), polyglyceryl-2 distearate (HLB: 4), and polyglyceryl-10 pentastearate (HLB: 3.5). Examples include polyglyceryl-3 stearate (HLB: 5).

[0027] The content of the polyglycerol fatty acid ester (B) in the oil-in-water emulsion composition of the present invention is preferably 0.05 to 10 wt %, more preferably 0.2 to 5 wt %, and even more preferably 0.5 to 2 wt %, based on the total weight of the composition. By using the composition in this range, the emulsion system becomes more stable, the composition spreads easily when applied to the skin, and the skin after application has an increased moisture content and improved softness, making it easier to obtain an excellent feel when used.

[0028] The anionic surfactant (C) in the present invention cooperates with the other surfactants, components (A) and (B), to realize a highly stable emulsion system and also contribute to a good feel when used.

[0029] Examples of component (C) include, but are not limited to, acyl lactate salts; fatty acid glyceryl sulfate salts; fatty acid soaps (e.g., sodium laurate, sodium palmitate, etc.); higher alkyl sulfate salts (e.g., sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfate salts (e.g., POE lauryl sulfate triethanolamine, POE lauryl sulfate sodium, etc.); N-acyl sarcosine acid (e.g., lauroyl sarcosine sodium, etc.); higher fatty acid amidosulfonate salts (e.g., N-myristoyl-N-methyl taurate sodium, coconut oil fatty acid methyl tauride sodium, lauryl methyl tauride sodium, etc.); phosphate salts (POE oleyl ether phosphate sodium, POE stearyl ether phosphate, etc.); sulfosuccinate salts (e.g., di-2-ethylhexyl sulfosuccinate sodium, monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.); alkylbenzene sulfonates (e.g., sodium linear dodecylbenzene sulfonate, triethanolamine linear dodecylbenzene sulfonate, linear dodecylbenzene sulfonic acid, etc.); N-acyl glutamates (e.g., monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, monosodium N-myristoyl-L-glutamate, etc.); sulfated oils (e.g., turmeric oil, etc.); POE alkyl ether carboxylic acids; POE alkyl allyl ether carboxylates; α-olefin sulfonates; higher fatty acid ester sulfonates; secondary alcohol sulfates; higher fatty acid alkylolamide sulfates; sodium lauroyl monoethanolamide succinate; ditriethanolamine N-palmitoyl aspartate; sodium caseinate, etc. Of these, acyl lactate and fatty acid glyceryl sulfate are particularly preferred.

[0030] The acyl lactate is preferably a salt of an ester of a fatty acid having 10 to 22 carbon atoms and lactic acid, and specific examples thereof include caproyl lactate, lauroyl lactate, stearoyl lactate, isostearoyl lactate, and behenoyl lactate. The fatty acid glyceryl sulfate is preferably an ester of a glyceride of a fatty acid having 10 to 22 carbon atoms with sulfuric acid, and specific examples thereof include hardened coconut oil fatty acid glycerin sulfate (cocoglyceryl sulfate). Preferred examples of these salts include salts with sodium, potassium, and the like.

[0031] Component (C) preferably has an HLB value of at least 9. There is no particular upper limit to the HLB value, but it is preferably 18 or less.

[0032] The content of the anionic surfactant (C) in the oil-in-water emulsion composition of the present invention is preferably 0.05 to 5 wt %, more preferably 0.1 to 1 wt %, and even more preferably 0.2 to 0.5 wt %, based on the total weight of the composition. By using the composition in this range, the emulsion system becomes more stable, the composition spreads easily when applied to the skin, and the skin after application has an increased moisture content and improved softness, making it easier to obtain an excellent feel when used.

[0033] The weight ratio (A) / ((B)+(C)) of the content of component (A) to the total content of components (B) and (C) in the oil-in-water emulsion composition of the present invention is preferably 0.005 to 50, more preferably 0.01 to 25, and even more preferably 0.1 to 10. By using the composition in this range, the emulsion system becomes more stable, the composition spreads easily when applied to the skin, and the skin after application has an increased moisture content and improved softness, making it easier to obtain an excellent feel when used.

[0034] It is preferable that the composition of the present invention further contains (D) a higher alcohol. In the present invention, the higher alcohol (D) forms a gel network together with the components (A), (B) and (C) to make the emulsion system more stable. In addition, the use of the component (D) in combination tends to improve the feel of the composition when it is used.

[0035] Examples of component (D) include, but are not limited to, cetyl alcohol (cetanol), batyl alcohol, stearyl alcohol, oleyl alcohol, isostearyl alcohol, behenyl alcohol, palmitoleyl alcohol, heptadecanol, 1-heptadecanol, elaidyl alcohol, oleyl alcohol, linoleyl alcohol, elaidolinoleyl alcohol, linolenyl alcohol, elaidolinolenyl alcohol, ricinoleyl alcohol, nonadecyl alcohol, arachidyl alcohol, heneicosanol, and erucyl alcohol.

[0036] When the oil-in-water emulsion composition of the present invention contains a higher alcohol (D), the content thereof is preferably 0.05 to 5 wt %, more preferably 0.1 to 4 wt %, and even more preferably 0.5 to 3 wt %, based on the total weight of the composition. By using the composition in this range, the emulsion system becomes more stable, and the feel of the composition when used becomes more favorable.

[0037] The formulation of the composition of the present invention is an oil-in-water emulsion. The oil-in-water emulsion is not particularly limited as long as the outermost phase is an aqueous phase, and may be an O / W type, a W / O / W type, or an (O1+O2) / W type.

[0038] The compositions of the present invention contain an aqueous phase component and an oil phase component. The composition of the present invention contains water as an aqueous phase component. The aqueous phase component may be any component that dissolves in water at 25 to 90°C in addition to water. Components (A), (B), and (C) may be dissolved in either the aqueous phase or the oil phase, but may be included in the aqueous phase component for convenience when calculating the internal phase ratio described below. The oil phase component is not limited to oil agents, but generally includes powders, etc., and may be any component that undergoes phase separation from water after being suspended in water at 25 to 90°C and left to stand for 1 hour. In the composition of the present invention, the weight ratio of the contents of the aqueous phase component to the oil phase component (internal phase ratio) is not particularly limited, but is preferably 99:1 to 50:50, more preferably 95:5 to 70:40.

[0039] The oil phase component is not particularly limited, but from the viewpoint of increasing the solubility of the components (A), (B) and (C) and facilitating the production of a uniform composition, a polar oil is preferred, and one having a high IOB value, for example, more than 0.1, is more preferred. The upper limit of the IOB value is not particularly limited, but may be, for example, less than 0.6.

[0040] The IOB value is the Inorganic / Organic Balance. IOB is an abbreviation for Inorganic-Organic Ratio, which is a value that indicates the ratio of inorganic value to organic value, and is an index that indicates the degree of polarity of an organic compound. Specifically, the IOB value is expressed as IOB value=inorganic value / organic value. For each of the "inorganic value" and "organic value", "inorganic value" is set according to various atoms or functional groups, for example, the "organic value" is 20 for one carbon atom in a molecule, and the "inorganic value" is 100 for one hydroxyl group, and the "inorganic value" and "organic value" are set according to various atoms or functional groups, and the IOB value of the organic compound can be calculated by accumulating the "inorganic value" and "organic value" of all atoms and functional groups in the organic compound (for example, see "Organic Conceptual Diagram-Basics and Applications" by Yoshio Koda, pp. 11-17, Sankyo Publishing, 1984).

[0041] Examples of preferred polar oils include dicaprylyl carbonate (IOB value = 0.235), caprylic / capric triglyceride (IOB value = 0.309), ethylhexyl salicylate (IOB value = 0.600), oleic acid (IOB value = 0.42), isostearic acid (IOB value = 0.43), isopropyl myristate (IOB value = 0.18), octyl palmitate (IOB value = 0.13), isopropyl palmitate (IOB value = 0.16), stearyl alcohol (IOB value = 0.17), ethylhexyl oleate (IOB value = 0.18), ethylhexyl oleate ... Butyl phosphate (IOB value = 0.14), hexyl laurate (IOB value = 0.17), myristyl myristate (IOB value = 0.11), decyl oleate (IOB value = 0.11), isononyl isononanoate (IOB value = 0.20), isotridecyl isononanoate (IOB value = 0.15), cetyl ethylhexanoate (IOB value = 0.13), glycol distearate (IOB value = 0.16), glyceryl diisostearate (IOB value = 0.29), Neopentyl glycol dicaprate (IOB value = 0.25), diisostearyl malate (IOB value = 0.28), trimethylolpropane triisostearate (IOB value = 0.16), glyceryl tri-2-ethylhexanoate (triethylhexanoin) (IOB value = 0.35), trimethylolpropane trioctanoate (IOB value = 0.33), diisobutyl adipate (IOB value = 0.46), N-lauroyl-L-glutamate-2-octyl Examples include dodecyl ester (IOB value = 0.29), 2-hexyldecyl adipate (IOB value = 0.16), diisopropyl sebacate (IOB value = 0.40), ethylhexyl methoxycinnamate (IOB value = 0.28), olive oil (IOB value = 0.16), castor oil (IOB value = 0.43), decyltetradecanol (IOB value = 0.21), octyldodecanol (IOB value = 0.26), and oleyl alcohol (IOB value = 0.28).

[0042] When the oil-in-water emulsion composition of the present invention contains a polar oil, the content thereof is preferably 1 to 50% by weight, more preferably 3 to 40% by weight, and even more preferably 5 to 30% by weight, based on the total weight of the composition. By using the components in the above ranges, the components (A), (B) and (C) become easily dissolved, facilitating the production of a homogeneous composition.

[0043] The oil-in-water emulsion composition of the present invention is preferably in the form of an external preparation for skin, specifically, in the form of a cosmetic, a quasi-drug, or a pharmaceutical.

[0044] The composition of the present invention can be produced according to a conventional method for producing an oil-in-water emulsion type.

[0045] The oil-in-water emulsion composition of the present invention can contain any other components that are usually used in cosmetics, so long as the effects of the present invention are not impaired. Examples of such optional components include other oils, powders, other alcohols, ethers, moisturizers, other surfactants, other oils, sequestering agents, pearlescent agents, amino acids, organic amines, polymer emulsions, pH adjusters, vitamins, antioxidants, preservatives, water-soluble polymers, fragrances, various active ingredients, UV scattering agents, etc.

[0046] Other alcohols include, for example, monohydric alcohols such as ethanol; dihydric alcohols such as ethylene glycol, 1,3-butylene glycol, trimethylene glycol, 1,2-butylene glycol, propylene glycol, dipropylene glycol, propanediol, 1,2-pentanediol, 3-methyl-1,3-butanediol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol, and octylene glycol; trihydric alcohols such as trimethylolpropane; tetrahydric alcohols such as pentaerythritol; pentahydric alcohols such as xylitol; polyhydric alcohol polymers such as triglycerin, tetraglycerin, and polyglycerin; sugar alcohols such as starch decomposition sugar reduced alcohols; and polyglycerin. Alcohol alkyl ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, and ethylene glycol isopropyl ether; alcohol alkyl ethers such as diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, and dipropylene glycol butyl ether; glycerin monoalkyl ethers such as xyl alcohol, selachyl alcohol, and batyl alcohol; Alcohol polymers such as diethylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, and polyethylene glycol; Glysolid; tetrahydrofurfuryl alcohol; POE-tetrahydrofurfuryl alcohol; POP-butyl ether; POP·POE-butyl ether; tripolyoxypropylene glycerin ether; POP-glycerin ether; POP-glycerin ether phosphate; POP·POE-pentaneerythritol ether, etc.

[0047] As for ethers, in addition to those corresponding to the above alcohols, Examples of the ethylene glycol dimethyl ether include ethylene glycol diethyl ether, ethylene glycol dibutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol methyl ethyl ether, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diadipate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, and propylene glycol monophenyl ether acetate.

[0048] The shape of the powder is not particularly limited, and may be spherical, needle-like, plate-like, etc., and examples of the powder include inorganic powders (e.g., talc, kaolin, mica, sericite, muscovite, phlogopite, synthetic mica, red mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, Metal tungstate salts, magnesium, silica, alumina, zeolite, barium sulfate, calcined calcium sulfate (calcined gypsum), calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, boron nitride, etc.; organic powders (e.g., polyamide resin powder (nylon powder), polyethylene powder, poly(methyl meth)acrylate powder, polystyrene powder, styrene and acrylic acid copolymer resin powder, silicone resin powder, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, etc.); metal soaps (e.g., mi Zinc stearate, calcium palmitate, aluminum stearate); inorganic white pigment (e.g., titanium dioxide, zinc oxide, etc.); inorganic red pigments (e.g., iron oxide (red oxide), iron titanate, etc.); inorganic brown pigments (e.g., gamma-iron oxide, etc.); inorganic yellow pigments (e.g., yellow iron oxide, ocher, etc.); inorganic black pigments (e.g., black iron oxide, low-order titanium oxide, etc.); inorganic purple pigments (e.g., mango violet, cobalt violet, etc.); inorganic green pigments (e.g., chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (e.g., ultramarine, Prussian blue, etc.); pearl pigments (e.g., titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scales, foil, etc.); metal powder pigments (e.g., aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium or aluminum lake (e.g., organic pigments such as Red 201, Red 202, Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, and Blue 404, Red 3, Red 104, Red 106, Red 227, Red 230, Red 401, Red 505, Orange 205, Yellow 4, Yellow 5, Yellow 202, Yellow 203, Green 3, and Blue 1, etc.); natural pigments (e.g., chlorophyll, β-carotene, etc.), etc.

[0049] Examples of moisturizing agents include chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO)PO adduct, Rosa rugosa extract, Achillea millefolium extract, and Melilot extract.

[0050] Other surfactants, i.e., surfactants other than alkyl glycosides, polyglycerol fatty acid esters, and anionic surfactants, include cationic surfactants, amphoteric surfactants, and nonionic surfactants other than alkyl glycosides and polyglyceryl laurate (other nonionic surfactants).

[0051] Examples of cationic surfactants include alkyltrimethylammonium salts (e.g., stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (e.g., cetylpyridinium chloride, etc.); distearyldimethylammonium chloride, dialkyldimethylammonium salts; poly(N,N'-dimethyl-3,5-methylenepiperidinium chloride); alkyl quaternary ammonium salts; alkyldimethylbenzylammonium salts; alkylisoquinolinium salts; dialkylmorphonium salts; POE alkylamines; alkylamine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride; benzethonium chloride, etc.

[0052] Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants (e.g., 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc.); betaine-based surfactants (e.g., 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryl dimethylaminoacetic acid betaine, alkyl betaine, amido betaine, sulfobetaine, etc.).

[0053] Examples of nonionic surfactants other than alkyl glycosides and polyglycerin fatty acid esters include polyether-modified silicones (e.g., polyethylene glycol-10 dimethicone, polyethylene glycol-12 dimethicone, etc.); polyglycerin-modified silicones (e.g., polyglyceryl-3 disiloxane dimethicone, polyglyceryl-3 polydimethylsiloxyethyl dimethicone, etc.); sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monostearate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexyl acid, diglycerol sorbitan tetra-2-ethylhexyl acid, etc.); glycerin fatty acids (e.g., glyceryl monocottonseed oil fatty acid, glyceryl monoerucate, glyceryl sesquioleate, glyceryl monostearate, glyceryl α,α'-oleate pyroglutamate, glyceryl (monostearate / malate), etc.); propylene glycol fatty acid esters (e.g., propylene glycol monostearate, etc.); POE castor oil / hydrogenated castor oil derivatives (POE castor oil, POE hydrogenated castor oil, etc.); and non-hydrophilic nonionic surfactants such as glycerin alkyl ethers.Also, POE sorbitan fatty acid esters (e.g., POE sorbitan monooleate, POE sorbitan monostearate, POE sorbitan tetraoleate, etc.); POE sorbit fatty acid esters (e.g., POE sorbit monolaurate, POE sorbit monooleate, POE sorbit pentaoleate, POE sorbit monostearate, etc.); POE glycerin fatty acid esters (e.g., POE monooleates such as POE glycerin monostearate, POE glycerin monoisostearate, POE glycerin triisostearate, etc.); POE fatty acid esters (e.g., POE distearate, POE monodioleate, distearate, etc.); ethylene glycol acrylate, etc.); POE alkyl ethers (e.g., POE lauryl ether, POE oleyl ether, POE stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE cholestanol ether, etc.); POE alkyl phenyl ethers (e.g., POE nonylphenyl ether, etc.); Pluronic types (e.g., Pluronic (registered trademark), etc.); POE·POP alkyl ethers (e.g., POE·POP cetyl ether, POE·POP-2-decyltetradecyl ether, POE·POP monobutyl ether, POE·POP hydrogenated lanolin, POE·POP glycerin ether, etc.); tetra Hydrophilic nonionic surfactants such as POE-tetra POP ethylenediamine condensates (e.g., Tetronic, etc.); POE castor oil hydrogenated castor oil derivatives (e.g., POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil triisostearate, POE hydrogenated castor oil monopyroglutamic acid monoisostearate diester, POE hydrogenated castor oil maleic acid, etc.); POE beeswax / lanolin derivatives (e.g., POE sorbitol beeswax, etc.); alkanolamides (e.g., coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE propylene glycol fatty acid esters; POE alkylamines; POE fatty acid amides; sucrose fatty acid esters; alkyl glucosides; alkyl ethoxydimethylamine oxides; and trioleyl phosphate.

[0054] However, it is preferable that the oil-in-water emulsion cosmetic of the present invention is substantially free of surfactants (other surfactants) other than alkyl glycosides, polyglycerol fatty acid esters, and anionic surfactants. Here, "substantially free" means that the content of such surfactants is preferably 3% by weight or less, more preferably 1% by weight or less, and even more preferably 0.5% by weight or less of the total cosmetic.

[0055] Other oils include silicone oils, natural oils, and hydrocarbon oils. Silicone oils include dimethylpolysiloxane (dimethicone), cyclopentasiloxane, decamethylcyclopentasiloxane, caprylyl methicone, trimethylsiloxyketone, Dimethicone / vinyl dimethicone crosspolymer, dimethicone / phenylvinyl Ludimethicone crosspolymer, etc. Examples of natural oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, Chinese giri oil, Japanese tung oil, jojoba oil, germ oil, sunflower oil, triglycerin, glyceryl trioctanoate, and glyceryl triisopalmitate. Examples of the hydrocarbon oil include isododecane, isohexadecane, squalane, hydrogenated poly(C6-12) olefin, and hydrogenated polyisobutene.

[0056] Examples of sequestering agents include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, and trisodium ethylenediaminehydroxyethyltriacetate.

[0057] Examples of pearlescent agents include glycol distearate and titanium mica.

[0058] Examples of the amino acid include neutral amino acids (e.g., threonine, cysteine, etc.); basic amino acids (e.g., hydroxylysine, etc.); and the like. Examples of the amino acid derivatives include sodium acyl sarcosine (sodium lauroyl sarcosine), Examples of such antibacterial agents include sodium glutamate, sodium acyl β-alanine, glutathione, and pyrrolidone carboxylic acid.

[0059] Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1-propanol.

[0060] Examples of polymer emulsions include acrylic resin emulsions, polyethyl acrylate emulsions, acrylic resin liquids, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, and natural rubber latex.

[0061] Examples of pH adjusters include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate. The pH of the oil-in-water emulsion composition of the present invention is not particularly limited, and is preferably in the pH range of typical external skin preparations such as cosmetics, specifically in the range from weakly acidic to neutral, and more specifically, a pH of about 5 to 7.

[0062] Vitamins include, for example, vitamins A, B1, B2, B6, C, E and their derivatives. , pantothenic acid and its derivatives, biotin, etc.

[0063] Examples of antioxidants include tocopherols, dibutylhydroxytoluene (BHT), butylhydroxyanisole, pyrosulfite, gallic acid esters, phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, cephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.

[0064] Examples of preservatives include parabens and phenoxyethanol.

[0065] Examples of water-soluble polymers include plant-based polymers (e.g., carrageenan, starch (co (corn, potato, wheat), glycyrrhizic acid); microbial polymers (e.g. natural water-soluble polymers such as animal polymers (e.g., collagen, casein, albumin, gelatin, etc.); Starch-based polymers (e.g., carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose-based polymers (hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, methylcellulose, ethylcellulose, hydroxypropylmethylcellulose stearoxy ether, sodium cellulose sulfate, carboxymethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, etc.); Examples of the water-soluble polymer include synthetic water-soluble polymers such as vinyl polymers (e.g., polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, carboxyvinyl polymer, etc.); polyoxyethylene polymers (e.g., polyethylene glycol 20,000, 40,000, 60,000, etc.); acrylic polymers (e.g., sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.); polyethyleneimine; and cationic polymers.

[0066] Examples of the various active ingredients include anti-inflammatory agents (e.g., glycyrrhizinic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.); whitening agents (e.g., placenta extract, saxifrage extract, arbutin, etc.); various extracts (e.g., Phellodendron bark, Coptis japonica, Lithospermum root, Peony root, Swertia japonica, Birch, Sage, Loquat, Carrot, Aloe, Mallow, Iris, Grape, Coix seed, Loofah, Lily, Saffron, Cnidium rhizome, Angelica acutiloba, Hypericum perforatum, Ononis, Garlic, Capsicum annuum, Citrus chinensis, Angelica acutiloba, Seaweed, etc.), activators (e.g., Royal jelly, , photosensitizers, cholesterol derivatives, etc.); blood circulation promoters (e.g., nonylic acid valenylamide, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, zingerone, cantharides tincture, ichthammol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, etc.); antiseborrheic agents (e.g., sulfur, thianthol, etc.); anti-inflammatory agents (e.g., tranexamic acid, thiotaurine, hypotaurine, etc.), etc. EXAMPLES

[0067] The present invention will be described in more detail below with reference to examples. However, the present invention is not limited to the following examples as long as it does not depart from the gist of the present invention.

[0068] <Test Example> The ingredients shown in Tables 1 to 3 were mixed to prepare each oil-in-water emulsion composition. The dissolution state of each of the obtained oil-in-water emulsion compositions was evaluated by an experienced evaluator. The results are shown in Table 1.

[0069] [Table 1]

[0070] [Table 2]

[0071] [Table 3]

[0072] <Moisture content of the stratum corneum> After washing and acclimation, the moisture content of the stratum corneum on the inside of the upper arm was measured using SKICON (200EX-USB, manufactured by Yayoi Co., Ltd.). After measuring the temperature using a measuring stick, 0.05 g of the composition was taken and applied to the inside of the upper arm. After 6 hours, the composition was washed off. The moisture content of the stratum corneum was measured again. Before application, the skin was evaluated on the following four-point scale. ◎: Increase after application of the composition is 1.3 or more ◯: Increase after application of the composition is 1.1 or more and less than 1.3 △: Increase after application of the composition is 1.0 or more and less than 1.1 ×: The increase rate after application of the composition is less than 1.0

[0073] <Skin flexibility> The composition was applied to the cheeks and then the skin softness 10 minutes later was evaluated by a skilled evaluator using the following criteria. ◎: Feels good flexibility 〇: Feels somewhat flexible △: No flexibility and feels hard ×: Feels stiff

[0074] <Good spreadability when applied> When the composition was applied to the cheek, the ease of spreading was evaluated by a skilled evaluator using the following criteria. ◎: Very easy to stretch 〇: Easy to stretch △: A little difficult to stretch ×: Difficult to stretch

[0075] <Emulsification stability> Each composition was placed in a standard glass bottle and left to stand in a thermostatic chamber set at 50° C. for one month, after which a specialist evaluator rated the composition on the following four-point scale. ◎: No change in shape 〇: Almost no change in shape △: Creaming is partially observed ×: More than half of the shape is not maintained [Industrial Applicability]

[0076] According to the present invention, a stable oil-in-water emulsion composition can be prepared. Specifically, the composition of the present invention spreads well and is easy to apply, and has excellent effects such as increasing the moisture content of the skin after application and improving its softness. Therefore, such a composition is suitable for external skin preparations such as cosmetics, meets the needs of consumers who want an excellent feeling when used, and is very useful industrially.

Claims

1. An oil-in-water emulsion composition comprising the following (A) to (C): (A) Alkyl glycoside (B) Polyglycerol fatty acid ester (C) Anionic surfactant

2. 2. The oil-in-water emulsion composition according to claim 1, wherein the component (A) is an alkyl glycoside represented by the following general formula (1): 【Chemistry 1】 (In the formula, N represents an integer of 2 to 7, R independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, and n represents an integer of 1 to 4.)

3. 2. The oil-in-water emulsion composition according to claim 1, wherein the content of the component (A) is 0.01 to 10% by weight based on the total weight of the composition.

4. 2. The oil-in-water emulsion composition according to claim 1, wherein the component (B) is a polyglycerol fatty acid ester obtained by ester condensation of one molecule of polyglycerol having a degree of polymerization of 2 to 10 with 2 to 5 molecules of a fatty acid having 16 or more carbon atoms.

5. 2. The oil-in-water emulsion composition according to claim 1, wherein the content of the component (B) is 0.05 to 10% by weight based on the total amount of the composition.

6. 2. The oil-in-water emulsion composition according to claim 1, wherein the HLB of the component (C) is 9 or more.

7. 2. The oil-in-water emulsion composition according to claim 1, wherein the component (C) is one or more anionic surfactants selected from acyl lactate salts and fatty acid glyceryl sulfate salts.

8. 2. The oil-in-water emulsion composition according to claim 1, wherein the content of the component (C) is 0.05 to 5% by weight based on the total amount of the composition.

9. 2. The oil-in-water emulsion composition according to claim 1, further comprising a component (D) a higher alcohol.

10. 10. The oil-in-water emulsion composition according to claim 9, wherein the component (D) is 0.05 to 5% by weight based on the total weight of the composition.

11. 2. The oil-in-water emulsion composition according to claim 1, wherein a weight ratio (A) / ((B)+(C)) of the content of component (A) to the total content of components (B) and (C) in the composition is 0.005 to 50.

12. The oil-in-water emulsion composition according to any one of claims 1 to 11, which is an external preparation for skin.

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