Sterilization and washing mechanism of dialysis system

Abstract

To provide a sterilization and washing mechanism of a dialysis system.SOLUTION: In a sterilization and washing mechanism of a dialysis system, a dialysate supply device 200 includes: a RO water introduction line 211: a first mixer 216 for diluting one of undiluted dialysate solutions by RO water and preparing a diluted solution; a second mixer 217 for diluting the other of the undiluted dialysate solutions by the diluted solution, and preparing a dialysate solution; a sodium hypochlorite injection line 240 for supplying sodium hypochlorite to the first mixer 216; an acid injection line 260 for supplying acid to the second mixer 217; a first RO water branch line 250 branching from the RO water introduction line 211; a second RO water branch line branching from the RO water introduction line 211 and connected to the acid injection line 260; and a flow channel switching control part 280 for executing switching control of flow channels of the RO water introduction line 211, the sodium hypochlorite injection line 240, the acid injection line 260, the first RO water branch line 250, and the second RO water branch line 270.SELECTED DRAWING: Figure 2

Description

[Technical Field]

[0001] The present invention relates to a sterilizing and cleaning mechanism for a dialysis system, and more particularly to a sterilizing and cleaning mechanism for a dialysis system that discharges a sterilizing cleaning solution that complies with dialysis wastewater standards. [Background technology]

[0002] Generally, in dialysis facilities such as hospitals and clinics where patients with impaired kidney function undergo dialysis therapy, particularly hemodialysis using a dialysis machine, the used dialysis fluid that is returned to the dialysis machine contains waste products, excess water, electrolyte components, etc. from the patient's blood, so the dialysis machine is periodically disinfected and cleaned. Periodic disinfection and cleaning of such dialysis machines prevents contaminants such as proteins and bacteria contained in used dialysis fluid from adhering to the piping inside the dialysis machine, which is the route through which the dialysis fluid travels, thereby reducing the function of the machine and preventing bacteria from contaminating the patient's blood through the dialysis membrane. It also prevents calcium, a component of the dialysis fluid that regulates blood calcium levels, from depositing inside the dialysis machine and causing the machine to malfunction. For disinfecting, cleaning, etc. of such dialysis machines, alkaline aqueous solutions such as sodium hypochlorite are used to wash and remove proteins remaining in the dialysis machine as contaminants after dialysis treatment, and acidic aqueous solutions such as hydrochloric acid and acetic acid are used to wash and remove calcium carbonate remaining in the dialysis machine as contaminants. In addition, in recent years, there have been incidents in which concrete sewer pipes have been damaged when dialysis wastewater discharged from dialysis facilities into the sewer system was acidic and significantly exceeded the sewage discharge standards set by the Sewerage Bureau. In response to this, three related organizations (the Japanese Society for Dialysis Therapy, the Japanese Association of Dialysis Physicians, and the Japanese Society of Clinical Engineers) have formulated dialysis wastewater standards for dialysis wastewater. According to this dialysis wastewater standard, the hydrogen ion exponent of used dialysis fluid and sterilized cleaning fluid when discharged from dialysis must be pH 5 to 9.

[0003] Therefore, in order to satisfy the dialysis wastewater standards for dialysis wastewater, there has been a conventional sterilization and cleaning mechanism for a dialysis system (see, for example, Patent Document 1) that uses a dialysis system equipped with a dialysis monitoring device c to which an artificial dialyzer is attached, a dialysis fluid supplying device b to supply dialysis fluid to the dialysis monitoring device c, an RO water generating device a to supply RO water to the dialysis fluid supplying device b, and a drainage channel to discharge used dialysis fluid from the dialysis monitoring device c, in which an alkaline aqueous solution d and an acid aqueous solution e supplied as sterilizing cleaning fluid into the dialysis fluid supplying device b are selectively diluted with RO water from the RO water generating device a and used to sterilize and clean the dialysis monitoring device c, and then the waste liquid consisting of the used alkaline aqueous solution and acid aqueous solution is neutralized using a neutralizing agent in a neutralization tank f installed in the drainage channel on the drain outlet g side downstream of the dialysis monitoring device c. On the other hand, there is a sterilization and cleaning mechanism for a dialysis system (see, for example, Patent Document 2) that is used in a dialysis system including a dialysis monitoring device c equipped with an artificial dialyzer as shown in Figure 9, a dialysate supplying device b that supplies dialysate to the dialysis monitoring device c, an RO water generating device a that supplies RO water to the dialysate supplying device b, and a drainage channel that discharges the dialysate used in the dialysis monitoring device c. The sterilization and cleaning mechanism uses hypochlorous acid water prepared by mixing a large amount of RO water with an alkaline aqueous solution d and an acid aqueous solution e in a hypochlorous acid water preparation device h provided on the RO water supply channel on the inlet side upstream of the dialysate supplying device b to sterilize and clean the dialysis monitoring device c by supplying the hypochlorous acid water to the dialysis monitoring device c via a liquid delivery pump h1, an on-off valve j, and the dialysate supplying device b. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 5-38495 [Patent Document 2] Japanese Patent Application Laid-Open No. 2004-130017 Summary of the Invention [Problem to be solved by the invention]

[0005] However, the sterilization and cleaning mechanism of these dialysis systems has the problem that when the dialysis monitoring device c is sterilized and cleaned by selectively diluting an alkaline aqueous solution d or an acid aqueous solution e, the used sterilization and cleaning solution violates wastewater regulations, which require a pH of 5 to 9 as a sewage discharge standard. To solve this problem, it is necessary to secure sufficient space to install a neutralization tank f for the used sterilization and cleaning solution on the drainage path downstream of the dialysis monitoring device c on the drain outlet g side, and to carry out sufficient neutralization treatment in this neutralization tank f using a neutralizing agent to meet the sewage discharge standard. In particular, the sterilization and cleaning mechanism of the latter dialysis system requires the installation of an additional hypochlorous water preparation device h on the RO water supply line on the inlet side, upstream of the dialysis fluid supply device b. Furthermore, since this hypochlorous water preparation device h uses a large liquid delivery pump, the sterilization and cleaning mechanism itself tends to become large, and there are also problems with installation space, even though dialysis facilities in urban areas are often located in a single room in a building.

[0006] Therefore, the present invention solves the problems associated with the prior art as described above. Specifically, the object of the present invention is to provide a sterilizing and cleaning mechanism for a dialysis system that achieves space saving in the dialysis system by incorporating a sterilizing and cleaning mechanism into the dialysis fluid supplying device, and achieves easy discharge of the sterilizing cleaning solution after cleaning the dialysis fluid supplying device and dialysis monitoring device by adjusting the pH of the sterilizing cleaning solution to within the range of dialysis wastewater standards. [Means for solving the problem]

[0007] The invention according to claim 1 is a sterilization and cleaning mechanism for a dialysis system including at least a dialysis fluid supplying device that prepares dialysis fluid by sequentially mixing two types of dialysis stock solutions with RO water, and a dialysis monitoring device that performs artificial dialysis using an artificial dialyzer with the dialysis fluid supplied from the dialysis fluid supplying device, The dialysis fluid supply device includes an RO water inlet line that introduces the RO water from the outside via a solenoid valve, a first mixer that is provided in the RO water inlet line and introduces one of the dialysis stock solutions via a solenoid valve and a volumetric pump and prepares a diluted solution by diluting it with the RO water in the RO water inlet line, a second mixer that is provided downstream of the first mixer and introduces the other of the dialysis stock solutions via a solenoid valve and a volumetric pump and prepares the dialysis fluid by diluting it with the diluted solution delivered from the first mixer, and a sodium hypochlorite injection pump that supplies sodium hypochlorite to the first mixer from the outside via a solenoid valve and a volumetric pump. The above-mentioned problem is solved by having an RO water inlet line, an acid injection line that supplies acid to the second mixer from the outside via a solenoid valve and a volumetric pump, a first RO water branch line that branches off from the RO water inlet line upstream of the first mixer and joins the sodium hypochlorite injection line between the solenoid valve and the volumetric pump, a second RO water branch line that joins the acid injection line between the solenoid valve and the volumetric pump, and a flow path switching control unit that switches and controls at least the flow paths of the RO water inlet line, the sodium hypochlorite injection line, the acid injection line, the first RO water branch line, and the second RO water branch line.

[0008] The invention of claim 2 further solves the above-mentioned problem by, in addition to the configuration of the sterilization and cleaning mechanism of the dialysis system described in claim 1, having the flow path switching control unit switch and set to configure a flow path for a flushing pretreatment step in which the dialysate supply device and the dialysis monitoring device are washed with water using only the RO water inlet line after dialysis treatment using the dialysis monitoring device.

[0009] The invention of claim 3 solves the above-mentioned problem by, in addition to the configuration of the sterilization and cleaning mechanism of the dialysis system described in claim 1, switching and setting the RO water inlet line, the sodium hypochlorite injection line, and the acid injection line to form a flow path for the sterilization process.

[0010] The invention of claim 4 further solves the above-mentioned problems by including, in addition to the configuration of the sterilization and cleaning mechanism of the dialysis system described in claim 1, a sterilization cleaning solution adjustment control means in which the flow path switching control unit controls the injection amount of the sodium hypochlorite mixed and diluted with RO water injected from the sodium hypochlorite injection line into the first mixer and the injection amount of acid injected from the acid injection line into the second mixer, thereby switching the pH adjustment of the sterilization cleaning solution between the alkaline side and the acid side within the dialysis wastewater standards.

[0011] The invention of claim 5 further solves the above-mentioned problem by, in addition to the configuration of the sterilizing and cleaning mechanism of the dialysis system described in claim 2, the sterilizing cleaning solution adjustment control means adjusts the concentration and pH of the sterilizing cleaning solution to the alkaline side and acid side within the dialysis wastewater standards by switching, at a predetermined cycle, the injection timing of the sodium hypochlorite mixed and diluted with RO water injected from the sodium hypochlorite injection line into the first mixer and the injection timing of the acid injected from the acid injection line into the second mixer.

[0012] The invention of claim 6 further solves the above-mentioned problem by, in addition to the configuration of the sterilization and cleaning mechanism of the dialysis system described in claim 2, switching the flow path switching control unit so that, after the sterilization step, the flow paths for the flushing finishing step are configured in the RO water inlet line, the first RO water branch line, and the sodium hypochlorite injection line downstream of the solenoid valves, and in the second RO water branch line and the acid injection line downstream of the solenoid valves. [Effects of the Invention]

[0013] According to the sterilization and cleaning mechanism of the dialysis system of the invention of claim 1, the dialysis fluid supply device comprises an RO water inlet line for introducing RO water from the outside via a solenoid valve, a first mixer provided in the RO water inlet line for introducing one of the dialysis stock solutions via a solenoid valve and a volumetric pump and preparing a dilution solution by diluting it with the RO water from the RO water inlet line, a second mixer provided downstream of the first mixer for introducing the other of the dialysis stock solutions via a solenoid valve and a volumetric pump and preparing a dialysis fluid by diluting it with the dilution solution delivered from the first mixer, a sodium hypochlorite injection line for externally supplying sodium hypochlorite to the first mixer via a solenoid valve and a volumetric pump, an acid injection line for externally supplying acid to the second mixer via a solenoid valve and a volumetric pump, and a first R The sterilizing and cleaning mechanism can be easily incorporated into the dialysis fluid supplying device by having an RO water branch line, a second RO water branch line that joins the acid injection line between the solenoid valve and the volumetric pump, and a flow path switching control unit that switches and controls at least the flow paths of the RO water inlet line, the sodium hypochlorite injection line, the acid injection line, the first RO water branch line, and the second RO water branch line. This eliminates the need to provide a neutralization tank on the drainage path that neutralizes the used sterilizing cleaning solution with a neutralizing agent, or to provide a hypochlorous acid water preparation device on the RO water supply path that prepares hypochlorous acid water as a sterilizing cleaning solution that does not require neutralization, as in the conventional case.The used sterilizing cleaning solution can be discharged into the drainage path within the dialysis wastewater standard pH range of 5 to 9, thereby not only achieving space savings in the dialysis system but also allowing the dialysis fluid and the sterilizing cleaning solution to be prepared using the same RO water supplied to the dialysis fluid supplying device, which can be easily switched between. Furthermore, according to the sterilization and cleaning mechanism of the dialysis system of the invention of claim 1, the dialysis fluid supply device is provided with a volumetric pump in the sodium hypochlorite injection line and a volumetric pump in the acid injection line. Compared to a case where these volumetric pumps are not provided, this makes it possible to adjust the concentration and pH of the sterilization cleaning fluid by switching the injection timing of sodium hypochlorite and the injection timing of acid at a predetermined cycle. Therefore, regardless of whether the sodium hypochlorite or acetic acid is supplied at a high concentration, the pH of the sterilization cleaning fluid supplied to the dialysis monitoring device, etc. can be adjusted to within the pH range of 6 to 9 specified in the dialysis wastewater standards. Furthermore, by merging the sodium hypochlorite injection line with the first mixer and the acid injection line with the second mixer, the sodium hypochlorite and acid are diluted in two stages in succession in the first and second mixers, which are different mixers, so that a uniformly and reliably mixed sterilizing cleaning solution can be sent to the internal piping of the dialysis monitoring device, etc.

[0014] According to the sterilization and cleaning mechanism for a dialysis system of the invention of claim 2, in addition to the effects of the invention of claim 1, the flow path switching control unit switches and sets the flow path for the flushing pre-treatment step in which the dialysate supplying device and the dialysis monitoring device are washed with water using only the RO water inlet line after dialysis treatment using the dialysis monitoring device, and thereby it is possible to wash away residues adhering to the internal piping of the dialysate supplying device and the dialysis monitoring device after dialysis treatment in this flushing pre-treatment step.

[0015] According to the sterilization and cleaning mechanism for a dialysis system of the invention of claim 3, in addition to the effects of the invention of claim 2, the flow path switching control unit switches and sets the flow path for the sterilization process to be composed of the RO water inlet line, the sodium hypochlorite injection line, and the acid injection line, so that the alkaline aqueous solution of sodium hypochlorite can wash away and remove proteins, bacteria, etc. that remain as contaminants in the dialysis monitoring device after dialysis treatment, and the acid aqueous solution of hydrochloric acid, acetic acid, etc. can wash away and remove calcium carbonate that remains as a contaminant in the dialysis monitoring device.

[0016] According to the sterilization and cleaning mechanism of a dialysis system of the invention of claim 4, in addition to the effects of the invention of claim 2, the flow path switching control unit has a sterilization cleaning solution adjustment control means that controls the injection amount of the sodium hypochlorite mixed and diluted with RO water injected from the sodium hypochlorite injection line into the first mixer and the injection amount of acid injected from the acid injection line into the second mixer, thereby switching the pH adjustment of the sterilization cleaning solution to either the alkaline or acid side of the dialysis wastewater standards, and thereby the pH of the sterilization cleaning solution sent to the dialysis monitoring device is precisely adjusted, so that the alkaline aqueous solution of sodium hypochlorite can reliably and effectively wash away proteins, bacteria, etc. that remain as contaminants in the dialysis monitoring device after dialysis treatment, and at the same time, the acid aqueous solution of hydrochloric acid, acetic acid, etc. can reliably and effectively wash away calcium carbonate that remains as a contaminant in the dialysis monitoring device.

[0017] According to the sterilizing and cleaning mechanism of a dialysis system of the invention of claim 5, in addition to the effects of the invention of claim 2, the sterilizing cleaning solution adjustment control means adjusts the concentration and pH of the sterilizing cleaning solution to the alkaline side and acid side of the dialysis wastewater standards by switching, at a predetermined period, the injection timing of the sodium hypochlorite mixed and diluted with RO water injected from the sodium hypochlorite injection line into the first mixer and the injection timing of the acid injected from the acid injection line into the second mixer, thereby reliably adjusting the pH of the sterilizing cleaning solution to be within the dialysis wastewater standards pH range of 5 to 9, and therefore sterilizing cleaning solution that complies with the dialysis wastewater standards can be discharged from the dialysis monitoring device.

[0018] According to the sterilization and cleaning mechanism of a dialysis system of the invention of claim 6, in addition to the effects of the invention of claim 1 or claim 2, the flow path switching control unit switches and sets the flow path for the flushing finishing process to be configured in the RO water inlet line, the downstream area of ​​the solenoid valve of the first RO water branch line and the sodium hypochlorite injection line, and the downstream area of ​​the solenoid valve of the second RO water branch line and the acid injection line after the sterilization process.This allows the sterilizing cleaning solution remaining in the sterilization process to be completely washed away in this flushing finishing process, completely preventing the sterilizing cleaning solution from remaining in the dialysis fluid during the next dialysis treatment. [Brief explanation of the drawings]

[0019] [Figure 1] 1 is a conceptual diagram of a dialysis system according to one embodiment of the present invention. [Figure 2] FIG. 1 is a system configuration diagram of a dialysis system according to an embodiment of the present invention. [Figure 3] 1 is an operational flow diagram of a dialysis system according to an embodiment of the present invention. [Figure 4] FIG. 2 is a diagram illustrating the connection configuration within the dialysis supply device in the dialysis treatment process of the present invention. [Figure 5] FIG. 10 is a diagram illustrating the connection configuration within the dialysis supply device during water washing in the sterilization and washing process of the present invention. [Figure 6] FIG. 10 is a diagram illustrating the connection configuration within the dialysis supply device during sterilization and cleaning in the sterilization and cleaning step of the present invention. [Figure 7] FIG. 10 is a diagram illustrating the connection configuration within the dialysis supply device during flushing in the sterilization and cleaning process of the present invention. [Figure 8] FIG. 1 is a diagram illustrating a sterilization and cleaning mechanism within a dialysis supply device in a conventional dialysis system. [Figure 9] FIG. 1 is a diagram showing a sterilization and cleaning mechanism provided upstream of a dialysate supply device in a conventional dialysis system. DETAILED DESCRIPTION OF THE INVENTION

[0020] The present invention provides a sterilization and cleaning mechanism for a dialysis system including at least a dialysis fluid supplying device that prepares dialysis fluid by sequentially mixing two types of dialysis stock solutions with RO water, and a dialysis monitoring device that performs artificial dialysis using an artificial dialyzer with the dialysis fluid supplied from the dialysis fluid supplying device, wherein the dialysis fluid supplying device includes an RO water inlet line that introduces RO water from the outside via a solenoid valve, a first mixer that is provided in the RO water inlet line and introduces one of the dialysis stock solutions via a solenoid valve and a volumetric pump and prepares a dilution solution by diluting it with the RO water from the RO water inlet line, a second mixer that is provided downstream of the first mixer and introduces the other of the dialysis stock solutions via a solenoid valve and a volumetric pump and dilutes it with the dilution solution delivered from the first mixer to prepare a dialysis fluid, and a sodium hypochlorite injection line that supplies sodium hypochlorite to the first mixer from the outside via a solenoid valve and a volumetric pump. the RO water inlet line upstream of the first mixer to join the sodium hypochlorite injection line between the solenoid valve and the volumetric pump; a second RO water branch line that joins the acid injection line between the solenoid valve and the volumetric pump; and a flow path switching control unit that controls switching of at least the flow paths of the RO water inlet line, the sodium hypochlorite injection line, the acid injection line, the first RO water branch line, and the second RO water branch line; a sterilizing and cleaning mechanism incorporated into the dialysis fluid supplying device to achieve space saving in the dialysis system; and a sterilizing and cleaning solution that adjusts the pH of the sterilizing cleaning solution within the range of dialysis wastewater standards to enable easy discharge after cleaning the dialysis fluid supplying device and the dialysis monitoring device.

[0021] For example, the present invention provides a sterilization and cleaning mechanism for a dialysis system that includes at least a dialysis fluid supplying device that sequentially mixes two types of dialysis concentrate with RO water to prepare dialysis fluid, and a dialysis monitoring device that performs artificial dialysis using an artificial dialyzer with the dialysis fluid supplied from the dialysis fluid supplying device.The dialysis fluid supplying device of the dialysis system may be configured to have a storage tank for storing dialysis fluid downstream of the second mixer, and to stably deliver dialysis fluid from this storage tank to the dialysis monitoring device.

[0022] The term "dialysis solution" as used herein refers to a perfusion solution for hemodialysis prepared by diluting a concentrate solution for dialysis called "solution A," which is obtained by dissolving agent A, mainly composed of electrolytes, glucose, etc., in RO water, with a concentrate solution for dialysis called "solution B," which is obtained by dissolving agent B, mainly composed of sodium bicarbonate, in RO water, in a ratio of, for example, solution A:solution B:RO water = 1:1.26:32.74. The term "diluted solution" as used herein refers to a solution obtained by diluting solution B, which is one of the two concentrate solutions for dialysis called "solution A" and "solution B." On the other hand, the acid supplied from the acid injection line described above is mixed with the sodium hypochlorite supplied from the sodium hypochlorite injection line to attack and easily eliminate the insides of bacteria remaining as contaminants in the dialysis monitoring device at a low concentration in a short time, and the pH is adjusted to produce either a slightly acidic hypochlorous acid solution that effectively washes away calcium carbonate, or a sodium hypochlorite solution that effectively washes away protein. Therefore, it is preferable to use acetic acid, which is a weak acid, but peracetic acid, citric acid, hydrochloric acid, or a buffer solution may also be used if consideration is given to dilution conditions, etc. More specifically, the acid supplied from the acid injection line is used by adjusting the pH to two different types: a sterilizing cleaning solution prepared at a pH of 5 to 6.5 with a sodium hypochlorite concentration of about 30 to 600 ppm, which effectively washes away calcium carbonate; and a sterilizing cleaning solution prepared at a pH of 6.6 to 9 with a sodium hypochlorite concentration of about 30 to 600 ppm, which effectively washes away protein. Therefore, it is most desirable to use acetic acid, which is a weak acid, but peracetic acid, citric acid, hydrochloric acid, or a buffer solution may also be used if consideration is given to dilution conditions, etc.

[0023] Furthermore, the dialysis fluid supply device (so-called central) used in the present invention is a multi-person dialysis fluid supply device connected to multiple dialysis monitoring devices (so-called consoles) in a large-scale dialysis facility, but it may also be connected to a personal dialysis device.

[0024] The RO water generator used in the dialysis system of the present invention removes impurities from raw water such as tap water by reverse osmosis to produce highly pure, clean water (RO water) used to prepare dialysis fluid. However, if such RO water can be supplied to the first mixer, the first RO water branch line, and the second RO water branch line provided in the dialysis fluid supply device via the RO water inlet line in the dialysis fluid supply device, the dialysis system of the present invention does not require the RO water generator as an essential component. Furthermore, the dialysis system of the present invention uses a first dialysis concentrate tank and a second dialysis concentrate tank that store liquid dialysis agents located outside the dialysis fluid supply device, but it is also possible to use a dialysis drug dissolving device that dissolves powdered dialysis agents consisting of agents A and B in RO water to obtain two types of dialysis concentrate solutions called solutions A and B.

[0025] Hereinafter, a sterilization and cleaning mechanism of a dialysis system according to one embodiment of the present invention will be described with reference to FIGS.

[0026] <1. Overview of dialysis system> First, an outline of a dialysis system according to one embodiment of the present invention will be described with reference to FIG.

[0027] As shown in FIG. 1, the dialysis system includes an RO water generating device 100 for generating RO water, a dialysate supplying device (so-called central) 200 for preparing a dialysate by sequentially mixing two types of dialysis concentrate solution with the RO water supplied from the RO water generating device 100 via an RO water supply path W, a plurality of dialysis monitoring devices (so-called consoles) 300 for performing artificial dialysis using an artificial dialyzer (dialyzer) 310 with the dialysate supplied from the dialysate supplying device 200, and a plurality of dialysis monitoring devices (so-called consoles) 300 for performing artificial dialysis using the dialyzer (dialyzer) 310. It consists of drainage channel D, which discharges the dialysis fluid used in 00 into the sewer pipe.

[0028] The RO water generation device 100 used in the present embodiment described above is a device that removes impurities from raw water such as tap water using reverse osmosis to generate highly pure and clean water (RO water) that can be used to prepare dialysis fluid and sterilized cleaning water. The dialysis fluid supply device 200 used in the above-described embodiment is a multi-person dialysis fluid supply device connected to multiple dialysis monitoring devices 300 in a large-scale dialysis facility, as shown in FIG. 1, but may also be connected to a personal dialysis device.

[0029] <2. Specific device configuration of the dialysis fluid supply device> As shown in Figure 2, the dialysis fluid supply device 200 used in the above-mentioned embodiment is composed of an RO water inlet line 211 to which RO water is supplied from the above-mentioned external RO water generation device 100 via an RO water supply path W, a first mixer 216 to which the RO water from this RO water inlet line 211 is introduced via an electromagnetic valve 212, a pressure meter 213, a constant flow valve 214, and a flow meter 215, a second mixer 217 connected downstream of this first mixer 216, a storage tank 218 connected downstream of this second mixer 217, and an outlet line 219 provided downstream of this storage tank 218 and leading to the above-mentioned dialysis monitoring device 300. The storage tank 218 used here is a tank for ensuring a sufficient flow rate for the dialysis monitoring device 300. It should be noted that the pressure gauge 213 and flow meter 215 used in this embodiment are intended to issue an alarm in the event of an abnormality in the RO water inlet line 211, through which RO water is supplied from the external RO water generation apparatus 100 via the RO water supply passage W, and the constant flow valve 214 is a valve for mechanically regulating the flow rate of the RO water inlet line 211, through which RO water is supplied from the external RO water generation apparatus 100 via the RO water supply passage W.

[0030] The dialysis solution supply device 200 used in this embodiment is configured to prepare dialysis solution by using a B solution injection line 220 that supplies the dialysis solution (solution B) supplied from the external first dialysis solution tank 400 to the first mixer 216 via a solenoid valve 221 and a volumetric pump 222, and a A solution injection line 230 that supplies the dialysis solution (solution A) supplied from the external second dialysis solution tank 500 to the second mixer 217 via a solenoid valve 231 and a volumetric pump 232. In the first mixer 216, the dialysis solution (solution B) supplied from the first dialysis solution tank 400 is diluted with RO water supplied from the RO water inlet line 211 to prepare a diluted solution, and further, in the second mixer 217, the dialysis solution (solution A) supplied from the second dialysis solution tank 500 is diluted with this diluted solution to prepare the dialysis solution to be supplied to the dialysis monitoring device 300. In this embodiment, the dialysis fluid supply device 200 is connected to the external first dialysis concentrate tank 400 and the second dialysis concentrate tank 500, respectively. However, instead of the first dialysis concentrate tank 400 and the second dialysis concentrate tank 500, the dialysis fluid supply device 200 may be connected to a dialysis drug dissolving device that dissolves powdered dialysis agents A and B (not shown) in RO water to prepare a dialysis concentrate solution consisting of solution A and a dialysis concentrate solution consisting of solution B.

[0031] The dialysis fluid supply device 200 used in this embodiment also includes a sodium hypochlorite injection line 240 that supplies sodium hypochlorite from an external sodium hypochlorite tank 600 to a first mixer 216 via an electromagnetic valve 241 and a volumetric pump 242 in order to prepare a sterilizing cleaning solution, and RO water that branches off from an RO water introduction line 211 that is piped upstream of the first mixer 216 and passes through an electromagnetic valve 251, and the sodium hypochlorite injection line 240 and the volumetric pump 242 are connected to the electromagnetic valve 241 of the sodium hypochlorite injection line 240. The system is composed of a first RO water branch line 250 that joins the first RO water branch line 250 between the volumetric pump 242, an acid injection line 260 that supplies acetic acid from an external acid tank 700 to the second mixer 217 via a solenoid valve 261 and a volumetric pump 262, and a second RO water branch line 270 that joins the RO water that branches off from the RO water introduction line 211 piped upstream of the first mixer 216 and passes through a solenoid valve 271 on the acid injection line 260 between the solenoid valve 261 and the volumetric pump 262.

[0032] In particular, in the dialysis fluid supply device 200 of the embodiment of the present invention, a volumetric pump 242 is provided on the sodium hypochlorite injection line 240, and a volumetric pump 262 is provided on the acid injection line 260. This makes it possible to adjust the concentration and pH of the sterilizing cleaning fluid by switching the injection timing of sodium hypochlorite and the injection timing of acid, for example, at a cycle of about 10 seconds. Therefore, even if either the sodium hypochlorite or the acetic acid is supplied at a high concentration, the pH of the sterilizing cleaning fluid supplied to the dialysis monitoring device 300, etc. is adjusted to within the range of pH 6 to 9 specified in the dialysis wastewater standards. Furthermore, by merging the sodium hypochlorite injection line 240 with the first mixer 216 and the acid injection line 260 with the second mixer 217, the sodium hypochlorite and the acid are diluted in two stages in succession in the first mixer 216 and the second mixer 217, so that a uniformly and reliably mixed and adjusted sterilizing cleaning solution is sent to the internal piping of the dialysis monitoring device 300, etc.

[0033] Furthermore, the dialysis fluid supply device 200 used in this embodiment has a flow path switching control unit 280 that controls the switching of the flow paths of the RO water introduction line 211, the solution B injection line 220, the solution A injection line 230, the sodium hypochlorite injection line 240, the first RO water branch line 250, the acid injection line 260, and the second RO water branch line 270, in order to be used in a dialysis treatment process or a sterilization cleaning process. Therefore, this flow path switching control unit 280 receives a flow rate signal output from the flow meter 215 in the RO water introduction line 211 and a valve opening / closing drive signal of the solenoid valve 212, a valve opening / closing drive signal S1 of a valve opening / closing detection sensor arranged close to the solenoid valve 221 in the B solution injection line 220 and a pump drive signal S2 of the volumetric pump 222, a valve opening / closing drive signal S3 of the solenoid valve 231 and a pump drive signal S4 of the volumetric pump 232 in the A solution injection line 230, a valve opening / closing drive signal S5 of the solenoid valve 241 and a pump drive signal S6 of the volumetric pump 242 in the sodium hypochlorite injection line 240, 50, a valve opening / closing drive signal S7 of the solenoid valve 251 in the acid injection line 260, a pump drive signal S9 of the volumetric pump 262, and a valve opening / closing drive signal S10 of the solenoid valve 271 in the second RO water branch line 270. Based on this, the flow paths of the RO water inlet line 211, the solution B injection line 220, the solution A injection line 230, the sodium hypochlorite injection line 240, the first RO water branch line 250, the acid injection line 260, and the second RO water branch line 270 are switched and controlled, thereby mutually switching between the dialysis treatment process and the sterilization cleaning process as shown in FIG.

[0034] 2.1. Specific Configuration of Flow Path Switching Control Unit in Dialysis Fluid Supply Device The flow path switching control unit 280 of the dialysis fluid supply device 200 described above has a sterilizing cleaning fluid adjustment control means 281 that controls the injection amount and injection timing of the sodium hypochlorite, which is mixed and diluted with RO water supplied from the first RO water branch line 250 and injected from the sodium hypochlorite injection line 240 into the first mixer 216, and the injection amount and injection timing of acetic acid, which is mixed and diluted with RO water supplied from the second RO water branch line 270 and injected from the acid injection line 260 into the second mixer 217, thereby switching the pH adjustment of the sterilizing cleaning fluid between the alkaline side and the acid side within the dialysis wastewater standards. Therefore, the sterilizing cleaning liquid adjustment control means 281 in the flow path switching control unit 280 controls the sterilizing cleaning liquid adjustment control means 281 based on the valve opening / closing drive signal S5 of the solenoid valve 241 in the sodium hypochlorite injection line 240 and the pump drive signal S6 of the volumetric pump 242, the valve opening / closing drive signal S7 of the solenoid valve 251 in the first RO water branch line 250, the valve opening / closing drive signal S8 of the solenoid valve 261 in the acid injection line 260 and the pump drive signal S9 of the volumetric pump 262, and the valve opening / closing drive signal S10 of the solenoid valve 271 in the second RO water branch line 270. In addition, the degree of mixing of sodium hypochlorite and acetic acid is adjusted and controlled, so that the pH of the sterilizing cleaning solution made of a slightly acidic hypochlorous acid aqueous solution for effectively cleaning and removing calcium carbonate adhering to the piping and the like in the dialysis monitoring device 300 can be adjusted to a pH of 5 to 6.5 within the dialysis wastewater standards, and the pH of the sterilizing cleaning solution made of a 30 to 600 ppm sodium hypochlorite aqueous solution for effectively cleaning and removing protein adhering to the piping and the like in the dialysis monitoring device 300 can be adjusted to a pH of 6 to 9 within the dialysis wastewater standards.

[0035] 2.2. Specific flow path configuration in the dialysis fluid supply device As shown in FIG. 3, the dialysate supplying device 200 used in this embodiment is configured to supply dialysate or sterilizing cleaning fluid to the dialysis monitoring device 300 by switching between a dialysis treatment process and a sterilizing cleaning process. That is, the dialysate supplying device 200 can supply dialysate to the dialysis monitoring device 300 in the dialysis treatment process, and supply sterilizing cleaning fluid to the dialysis monitoring device 300 in the sterilizing cleaning process.

[0036] <3.Dialysis monitoring device> The dialysis monitoring device 300 used in the present embodiment described above is a device that monitors the dialysate flow rate, temperature, venous pressure, etc. when performing hemodialysis, and multiple devices are installed for each dialysis patient in a dialysis facility. Furthermore, the dialysis monitoring device 300 can be equipped with an exchangeable artificial dialyzer 310 for each dialysis patient P in order to perform hemodialysis, which is a dialysis treatment.

[0037] <4. Drainage channel> The drainage channel D is basically a flow path for discharging the dialysis fluid used in the dialysis monitoring device 300 during dialysis treatment, but during sterilization cleaning, the used sterilization cleaning fluid (waste liquid) is discharged into the drain (i.e., the sewer).

[0038] The specific connection configurations in the dialysis treatment process and the sterilization and cleaning process will be described below. <5.1. Connection form during dialysis treatment in the dialysis treatment process> FIG. 4 shows the connection configuration in the dialysis treatment process. In the dialysis fluid supply device 200 of this embodiment, an RO water inlet line 211 connected to an external RO water production device 100 is sequentially connected to a solenoid valve 212, a pressure meter 213, a constant flow valve 214, a flow meter 215, a first mixer 216, a second mixer 217, a storage tank 218, and an outlet line 219. A solution B injection line 220, which supplies a dialysis fluid (solution B) from an external first dialysis fluid tank 400 via a solenoid valve 221 and a volumetric pump 222, joins the first mixer 216. A solution A injection line 230, which supplies a dialysis fluid (solution A) from an external second dialysis fluid tank 500 via a solenoid valve 231 and a volumetric pump 232, joins the second mixer 217, thereby preparing the dialysis fluid, which is then supplied to the dialysis monitoring device 300. At this time, the solenoid valve 251 of the first RO water branch line 250, the solenoid valve 241 of the sodium hypochlorite injection line 240, the solenoid valve 271 of the second RO water branch line 270, and the solenoid valve 261 of the acid injection line 260 are all in a closed state.

[0039] Next, the dialysis fluid supplying device 200 of this embodiment can be configured to have a sterilization and cleaning mechanism consisting of water washing, sterilization and cleaning, and flushing in the sterilization and cleaning process as follows. <5.2. Connection form when washing with water in the sterilization and washing process> Figure 5 shows the connection configuration during water washing in the sterilization and cleaning process. In the dialysis fluid supply device 200 of this embodiment, an RO water inlet line 211 connected to an external RO water production device 100 is connected in sequence to a solenoid valve 212, a pressure gauge 213, a constant flow valve 214, a flow meter 215, a first mixer 216, a second mixer 217, a storage tank 218, and an outlet line 219, and the RO water supplied from the external RO water production device 100 is supplied to the dialysis monitoring device 300 via the outlet line 219. At this time, the solenoid valve 251 of the first RO water branch line 250, the solenoid valve 241 of the sodium hypochlorite injection line 240, the solenoid valve 271 of the second RO water branch line 270, the solenoid valve 261 of the acid injection line 260, the solenoid valve 221 of the B liquid injection line 220, and the solenoid valve 231 of the A liquid injection line 230 are all in a closed state.

[0040] <5.3. Connection configuration during sterilization and cleaning in the sterilization and cleaning process> FIG. 6 shows the connection configuration during sterilization cleaning in the sterilization cleaning step. In the dialysis fluid supply device 200 of this embodiment, an RO water inlet line 211 connected to the external RO water generation device 100 is sequentially connected to a flow meter 215, a solenoid valve 212, a first mixer 216, a second mixer 217, a storage tank 218, and an outlet line 219. An external sodium hypochlorite injection line 240 joins the first mixer 216 via a solenoid valve 241 and a volumetric pump 242, and an external acid injection line 260 joins the second mixer 217 via a solenoid valve 261 and a volumetric pump 262, thereby preparing a sterilization cleaning solution, which is then supplied to the dialysis monitoring device 300. At this time, the solenoid valve 251 of the first RO water branch line 250, the solenoid valve 271 of the second RO water branch line 270, the solenoid valve 221 of the liquid B injection line 220, and the solenoid valve 231 of the liquid A injection line 230 are all closed.

[0041] <5.4. Connection configuration during flushing in the sterilization and cleaning process> FIG. 7 shows the connection configuration during flushing in the sterilization and cleaning process. In the dialysis fluid supply device 200 of this embodiment, an RO water inlet line 211 connected to an external RO water production device 100 is sequentially connected to a flow meter 215, an electromagnetic valve 212, a first mixer 216, a second mixer 217, a storage tank 218, and an outlet line 219. RO water supplied from a first RO water branch line 250 merges with the first mixer 216 via an electromagnetic valve 251 and a volumetric pump 242, and RO water supplied from a second RO water branch line 270 merges with the second mixer 217 via an electromagnetic valve 271 and a volumetric pump 262, thereby supplying RO water to the dialysis monitoring device 300. At this time, the solenoid valve 251 of the first RO water branch line 250, the solenoid valve 271 of the second RO water branch line 270, the solenoid valve 221 of the liquid B injection line 220, and the solenoid valve 231 of the liquid A injection line 230 are all closed.

[0042] <6. Effects of the sterilization and cleaning mechanism of the dialysis system according to this embodiment> As is clear from the above description, according to the sterilization and cleaning mechanism of the dialysis system 1 which is one embodiment of the present invention, the dialysis fluid supply device 200 comprises an RO water inlet line 211 which introduces RO water from the outside via a solenoid valve 212, a first mixer 216 which is provided in the RO water inlet line 211 and introduces solution B, which is one of the dialysis stock solutions, via a solenoid valve 221 and a volumetric pump 222 and prepares a dilution solution by diluting it with the RO water from the RO water inlet line 211, a second mixer 217 which is provided downstream of the first mixer 216 and introduces solution A, which is the other of the dialysis stock solutions, via a solenoid valve 231 and a volumetric pump 232 and prepares a dialysis fluid by diluting it with the dilution solution delivered from the first mixer 216, and a second mixer 217 which delivers sodium hypochlorite to the first mixer 216 via a solenoid valve 241 and a volumetric pump 242. the acid injection line 260 for supplying acetic acid to the second mixer 217 from the outside via a solenoid valve 261 and a volumetric pump 262; a first RO water branch line 250 branching from the RO water introduction line 211 upstream of the first mixer 216 and joining the sodium hypochlorite injection line 240 between the solenoid valve 241 and the volumetric pump 242; a second RO water branch line 270 joining the acid injection line 260 between the solenoid valve 261 and the volumetric pump 262; and a flow path switching control unit 280 for switching and controlling at least the flow paths of the RO water introduction line 211, the sodium hypochlorite injection line 240, the acid injection line 260, the first RO water branch line 250, and the second RO water branch line 270. As a result, the sterilizing and cleaning mechanism can be easily incorporated into the dialysis fluid supplying device 200, eliminating the need to provide a neutralization tank on the drainage channel to neutralize the used sterilizing cleaning solution with a neutralizing agent, as in the conventional case, or to provide a hypochlorous water preparation device on the RO water supply channel to prepare hypochlorous water as a sterilizing cleaning solution that does not require neutralization.The used sterilizing cleaning solution is discharged into the drainage channel within the dialysis wastewater standard pH range of 5 to 9, thereby not only achieving space saving for the dialysis system 1, but also allowing the preparation of the dialysis fluid and the sterilizing cleaning solution to be easily switched between using the same RO water supplied to the dialysis fluid supplying device 200.

[0043] Then, the flow path switching control unit 280 of the dialysis fluid supplying device 200 switches and sets the flow path to form a flow path for a flushing pretreatment step in which the dialysis fluid supplying device 200 and the dialysis monitoring device 300 are flushed with water using only the RO water inlet line after dialysis treatment using the dialysis monitoring device. In this flushing pretreatment step, residues adhering to the internal piping of the dialysis fluid supplying device 200 and the dialysis monitoring device 300 after dialysis treatment can be washed away.

[0044] Furthermore, the flow path switching control unit 280 switches and sets the flow path for the sterilization process to be composed of the RO water inlet line 211, the sodium hypochlorite injection line 240, and the acid injection line 260 after the flushing pretreatment process, so that the alkaline aqueous solution of sodium hypochlorite can wash away and remove proteins, bacteria, etc. that remain as contaminants in the dialysis monitoring device 300 after dialysis treatment, and the acid aqueous solution made of acetic acid can wash away and remove calcium carbonate that remains as a contaminant in the dialysis monitoring device 300.

[0045] Furthermore, the flow path switching control unit 280 has a sterilizing cleaning solution adjustment control means 281 that controls the injection amount of sodium hypochlorite mixed and diluted with RO water injected from the sodium hypochlorite injection line into the first mixer 216 and the injection amount of acid injected from the acid injection line 260 into the second mixer 217, thereby switching the pH adjustment of the sterilizing cleaning solution between the alkaline and acid sides of the dialysis wastewater standards.This allows the pH of the sterilizing cleaning solution to be precisely adjusted, so that the alkaline aqueous solution of sodium hypochlorite can reliably and effectively wash away proteins, bacteria, and other contaminants remaining in the dialysis monitoring device 300 after dialysis treatment, and the acid aqueous solution of hydrochloric acid, acetic acid, or the like can reliably and effectively wash away calcium carbonate remaining in the dialysis monitoring device 300 as a contaminant.

[0046] In addition, the sterilizing cleaning solution adjustment control means 281 switches the injection timing of sodium hypochlorite mixed and diluted with RO water injected from the sodium hypochlorite injection line 240 into the first mixer 216 and the injection timing of acid injected from the acid injection line 260 into the second mixer 217, for example, at a cycle of about 10 seconds, thereby adjusting the concentration and pH of the sterilizing cleaning solution to the alkaline and acid sides of the dialysis wastewater standards, thereby reliably adjusting the pH of the sterilizing cleaning solution to be within the dialysis wastewater standard pH range of 5 to 9, and therefore allowing sterilizing cleaning solution that complies with the dialysis wastewater standards to be discharged from the dialysis monitoring device 300.

[0047] Then, the flow path switching control unit 280 switches and sets the flow path for the flushing finishing process to be configured after the sterilization process at the RO water inlet line 211, the first RO water branch line 250, and the downstream area of ​​the solenoid valve 241 of the sodium hypochlorite injection line 240, and the downstream area of ​​the solenoid valve 261 of the second RO water branch line 270 and the acid injection line 260. This makes it possible to completely wash away the sterilizing cleaning solution remaining in the sterilization process, which has a significant effect, such as completely preventing the sterilizing cleaning solution from remaining, which tends to be mixed into the dialysis fluid during the next dialysis treatment. [Explanation of symbols]

[0048] 1. Dialysis System 100...RO water generator 200 ··· Dialysate supply device 211 RO water inlet line 212 Solenoid valve (for RO water) 213 Pressure gauge 214 Constant flow valve 215...Flowmeter 216 First mixer 217 Second mixer 218 Storage Tank 219 Derivation line 220 B liquid injection line 221 Solenoid valve 222 ··· Positive displacement pump 230 A liquid injection line 231 Solenoid valve 232 ··· Positive displacement pump 240 Sodium hypochlorite injection line 241 Solenoid valve 242 ··· Positive displacement pump 250 ··· First RO water branch line (for flushing the sodium hypochlorite injection line) 251 Solenoid valve (for flushing sodium hypochlorite injection line) 260 Acid injection line 261 Solenoid valve 262 ··· Positive displacement pump 270 - Second RO water branch line (for acid injection line flushing) 271 Solenoid valve (for acid injection line flushing) 280 Flow path switching control section 281 Sterilizing cleaning solution adjustment control means 300... Dialysis monitoring device 310 Dialysis Machine (Dialyzer) 400 First dialysis solution tank (solution B) 500 - Second dialysis solution tank (solution A) 600 ··· Sodium hypochlorite tank 700 Acid Tank D...Drainage channel P...dialysis patient W...RO water supply line S1: Valve opening / closing drive signal for solenoid valve 221 S2: Pump drive signal for volumetric pump 222 S3: Valve opening / closing drive signal for solenoid valve 231 S4: Pump drive signal for the volumetric pump 232 S5: Valve open / close drive signal for solenoid valve 241 S6: Pump drive signal for volumetric pump 242 S7: Valve open / close drive signal for solenoid valve 251 S8: Valve open / close drive signal for solenoid valve 261 S9: Pump drive signal for volumetric pump 262 S10: Valve open / close drive signal for solenoid valve 271 a...RO water generator b. Dialysis fluid supply device (central) c Dialysis monitoring device (console) d Sodium hypochlorite tank e Acid tank f...neutralization tank g...Drain port h ··· Hypochlorous acid water production device h1 Liquid delivery pump i Automatic valve for RO water j Automatic valve for sterilizing cleaning solution

Claims

1. A sterilization and cleaning mechanism for a dialysis system including at least a dialysis fluid supplying device that sequentially mixes two types of dialysis stock solutions with RO water to prepare a dialysis fluid, and a dialysis monitoring device that performs artificial dialysis using an artificial dialyzer with the dialysis fluid supplied from the dialysis fluid supplying device, The dialysis fluid supplying device includes an RO water introduction line for introducing the RO water from the outside via a solenoid valve, a first mixer provided in the RO water introduction line for introducing one of the dialysis stock solutions via a solenoid valve and a volumetric pump and preparing a dilution solution by diluting the one of the dialysis stock solutions with the RO water from the RO water introduction line, a second mixer provided downstream of the first mixer for introducing the other of the dialysis stock solutions via a solenoid valve and a volumetric pump and preparing the dialysis fluid by diluting the other with the dilution solution delivered from the first mixer, and a sodium hypochlorite supplying device for supplying sodium hypochlorite from the outside to the first mixer via a solenoid valve and a volumetric pump. a sodium hypochlorite injection line, an acid injection line for supplying acid from the outside to the second mixer via a solenoid valve and a volumetric pump; a first RO water branch line branching from the RO water inlet line upstream of the first mixer and joining the sodium hypochlorite injection line between the solenoid valve and the volumetric pump; a second RO water branch line joining the acid injection line between the solenoid valve and the volumetric pump; and a flow path switching control unit for switching and controlling at least the flow paths of the RO water inlet line, the sodium hypochlorite injection line, the acid injection line, the first RO water branch line, and the second RO water branch line.

2. 2. The sterilization and cleaning mechanism of the dialysis system according to claim 1, wherein the flow path switching control unit switches and sets a flow path for a pre-flushing treatment step in which the dialysis fluid supply device and the dialysis monitoring device are flushed with water using only the RO water inlet line after dialysis treatment by the dialysis monitoring device.

3. 2. The sterilization and cleaning mechanism of the dialysis system according to claim 1, wherein the flow path switching control unit switches and sets the RO water introduction line, the sodium hypochlorite injection line, and the acid injection line to constitute a flow path for a sterilization process.

4. The sterilizing and cleaning mechanism of the dialysis system according to claim 1, characterized in that the flow path switching control unit has a sterilizing cleaning solution adjustment control means for switching and using pH adjustment of the sterilizing cleaning solution to the alkaline side or the acid side within the dialysis wastewater standards by controlling the injection amount of the sodium hypochlorite mixed and diluted with RO water injected from the sodium hypochlorite injection line into the first mixer and the injection amount of acid injected from the acid injection line into the second mixer.

5. 3. The sterilizing and cleaning mechanism of the dialysis system according to claim 2, wherein the sterilizing and cleaning solution adjustment control means adjusts the concentration and pH of the sterilizing cleaning solution to the alkaline side and the acid side within the dialysis effluent standards by switching, at a predetermined cycle, the injection timing of the sodium hypochlorite mixed and diluted with RO water injected from the sodium hypochlorite injection line into the first mixer and the injection timing of the acid injected from the acid injection line into the second mixer.

6. 3. The sterilization and cleaning mechanism of the dialysis system according to claim 2, wherein the flow path switching control unit switches and sets the flow paths for the flushing finishing step to be configured in the RO water inlet line, the first RO water branch line, and the sodium hypochlorite injection line downstream of the solenoid valve, and in the second RO water branch line and the acid injection line downstream of the solenoid valve after the sterilization step.

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