Dynamic image analyzer

Abstract

To provide a technique for reducing the operating time of a user for collecting particles contained in a sample subjected to dynamic image analysis.SOLUTION: A dynamic image analyzer 100 disclosed herein is for analyzing particles contained in a liquid sample S1. The dynamic image analyzer 100 comprises a cell 2 for the liquid sample S1 to pass through, an image capturing unit 7 for capturing images of the particles passing through the cell 2, and a capturing unit 3 located downstream of the cell 2 to isolate the particles from the liquid and capture the particles.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to dynamic image analysis devices, and more particularly to techniques for collecting particles after an image has been captured. [Background technology]

[0002] A dynamic image analyzer is used to analyze images of particles in a liquid sample. As shown in JP 2019-100988 A (Patent Document 1), for example, the dynamic image analyzer captures an image of a predetermined area in a flow channel while a sample is flowing through the flow channel, and analyzes the image. If particles are included in the image, the dynamic image analyzer analyzes the shape of the particles from the acquired image information. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2019-100988 A Summary of the Invention [Problem to be solved by the invention]

[0004] In an analysis using a dynamic image analyzer, information on the shape of particles is obtained from the captured image. However, for example, when a sample contains multiple types of particles with similar shapes, it may be difficult to identify the type of detected particle.

[0005] The user can estimate the type of particle by subjecting the particle to an analysis other than the dynamic image analysis. In order to subject the particle to another analysis, the user needs to collect the particle contained in the sample after the dynamic image analysis. Therefore, the user needs to collect the particle separately from the dynamic image analysis process, which may increase the user's work time.

[0006] The present disclosure has been made in view of the above circumstances, and has an objective to reduce the time required by a user to recover particles contained in a sample that has been subjected to dynamic image analysis. [Means for solving the problem]

[0007] A dynamic image analysis device according to an aspect of the present disclosure is a dynamic image analysis device that analyzes particles contained in a liquid sample, and includes a cell through which the liquid sample passes, an imaging unit that captures images of the particles passing through the cell, and a collection unit that is disposed downstream of the cell and separates the particles from the liquid and collects them. Effect of the Invention

[0008] According to the present disclosure, a technique is provided for shortening a user's work time in recovering particles contained in a sample that has been subjected to dynamic image analysis. [Brief description of the drawings]

[0009] [Figure 1] FIG. 1 is a schematic diagram of a dynamic image analysis device. [Diagram 2] FIG. 1 is a block diagram showing a schematic configuration of a conventional dynamic image analysis device. [Diagram 3] FIG. 13 is a block diagram showing a modified example of the dynamic image analysis device. [Figure 4] FIG. 13 is a block diagram showing another modified example of the dynamic image analysis device. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] The embodiments of the present disclosure will be described in detail with reference to the drawings. In the drawings, the same or corresponding parts are designated by the same reference numerals and the description thereof will not be repeated.

[0011] [Embodiment Mode] First, the configuration of a dynamic image analyzer in an embodiment of the present disclosure will be described. FIG. 1 is a schematic diagram showing the configuration of a dynamic image analyzer 100 in an embodiment. As shown in FIG. 1, the dynamic image analyzer 100 includes a sample introduction section 1, a cell 2, a collection section 3, a pump 4, a waste liquid container 5, a light source 6, an image capture section 7, and a control device 8. The dynamic image analyzer captures images of particles contained in a liquid sample, and analyzes the shape of the particles and the density of the particles in the liquid sample. The liquid sample is, for example, a biopharmaceutical. The shape of the particles refers to, for example, the particle size and the circularity of the particles.

[0012] The sample introduction unit 1 is connected to the cell 2 via a flow path, and introduces a liquid sample S1 containing particles into the dynamic image analysis device 100. The liquid sample S1 introduced by the sample introduction unit 1 moves to the cell 2. The sample introduction unit 1 is, for example, a pipette tip.

[0013] The cell 2 includes a housing 21 and a flow path 22. The housing 21 is a substantially transparent container and has a substantially rectangular plate shape. An inlet of the flow path 22 is formed on the upper end surface of the cell 2, and the inlet is connected to the sample introduction section 1. An outlet of the flow path 22 is formed on the lower end surface of the cell 2, and the outlet is connected to the collection section 3. Particles P1 contained in the liquid sample S1 pass through the flow path 22.

[0014] The collection unit 3 includes a housing 31, a flow path 32, and a filter 33. The collection unit 3 collects particles P2 contained in the liquid sample S1 passing through the flow path 32 by the filter 33. The housing 31 is made of, for example, stainless steel. The material of the filter 33 is not limited, but may be, for example, polytetrafluoroethylene, stainless steel, or alumina. The pore size of the filter 33 is also not limited, but may be, for example, 100 nm to 1000 μm. The material and pore size of the filter may be determined in advance, or may be selected by the user depending on the particles to be collected, the type of sample, and the method for analyzing the collected particles.

[0015] The pump 4 is connected to the collection section 3 via a flow path. The pump 4 sucks the liquid sample S1 introduced into the sample introduction section 1, causing the liquid sample S1 to move through the cell 2 and the collection section 3. The pump 4 is formed of, for example, a syringe.

[0016] The waste liquid container 5 is connected to the pump 4 and stores the waste liquid S2 discharged from the pump 4. The waste liquid container 5 is, for example, a beaker.

[0017] The light source 6 irradiates the light beam A1 from a direction substantially perpendicular to the flow path formed inside the cell 2. The light source 6 has a light emitting element (for example, an LED (light emitting diode) and a laser light source) and a collimating optical system that collimates the light emitted from the light emitting element.

[0018] The photographing unit 7 includes a lens 71, an image sensor 72, and a signal processing circuit 73. The photographing unit 7 is disposed at a position facing the light source 6 across the cell 2, and photographs an image of a predetermined area in the flow channel 22.

[0019] The lens 71 is a lens designed so that the light ray A2 that has passed through the cell 2 is incident on the lens 71 and the light ray A3 that has passed through the lens 71 travels parallel to the optical axis. The lens 71 is, for example, a telecentric lens.

[0020] The image sensor 72 converts the light beam A3 into digital image data. The image sensor 72 is, for example, a charge coupled device (CCD) and a complementary metal oxide semiconductor (CMOS).

[0021] The signal processing circuit 73 converts the analog image data output from the imaging element 72 into a digital signal. The converted image data is sent to the control device 8.

[0022] The control device 8 includes a controller 81, an input unit 85, and an output unit 86. The input unit 85 and the output unit 86 are connected to the controller 81. The control device 8 analyzes the image data acquired by the imaging unit 7, and analyzes the density and shape of the particles. The control device 8 is, for example, a computer. Note that the control device 8 does not need to be configured by one computer, and may be configured by multiple computers.

[0023] The controller 81 includes, as its main components, a processor 82, a memory 83, and an input / output interface (I / F) 84. These components are connected to each other via a bus so as to be able to communicate with each other.

[0024] The processor 82 is an example of an electric circuit, and executes a given program to analyze the image acquired by the photographing unit 7. The program executed by the processor 82 may be stored in the memory 83, or may be stored in a storage device outside the control device 8. The processor 82 is, for example, a CPU (Central Processing Unit). The processor 82 may be implemented as hardware, software, or a combination thereof.

[0025] The memory 83 can store programs executed by the processor 82, images captured by the imaging unit 7, and results of analyzing the images. The memory includes volatile memory (e.g., RAM (Random Access Memory)) and non-volatile memory (e.g., ROM (Read Only Memory), a hard disk drive, and a solid state drive).

[0026] The input / output I / F 84 is an interface for transmitting various types of data between the processor 82 and the imaging unit 7, the input unit 85, and the output unit 86 connected to the input / output I / F 84.

[0027] The input unit 85 accepts information input to the controller 81. The information is, for example, information about the imaging interval, the measurement time, the measurement item, and the sample. The input unit 85 is composed of, for example, a touch panel, a mouse, and a keyboard.

[0028] The output unit 86 displays information according to instructions from the controller 81. The information is, for example, the results of analyzing the image, measurement setting conditions, and information related to the sample. The output unit 86 is, for example, configured with a liquid crystal display capable of displaying images.

[0029] [Comparative Example] 2 is a block diagram showing a schematic configuration of a conventional dynamic image analyzer 100B. Dynamic image analyzer 100B includes a sample introduction section 1, a cell 2, a pump 4, a waste liquid container 5, a light source 6, an image capture section 7, and a control device 8. When a liquid sample containing particles is analyzed by dynamic image analyzer 100B, the particles after analysis are discharged into waste liquid container 5 together with the sample liquid.

[0030] By analyzing a liquid sample containing particles using dynamic image analysis device 100B, a user can obtain information about the shape of the particles. For example, in a quality inspection of a liquid sample, a user can use dynamic image analysis to check whether the sample is contaminated with foreign matter.

[0031] However, in some cases, a user can only obtain information on the shape of particles through analysis using the dynamic image analyzer 100B, and cannot clarify the physicochemical properties of the particles. For example, in the quality inspection of a liquid sample, a foreign substance that has been mixed in may be identified. In such a case, the foreign substance is analyzed by other analytical methods, such as microscopic infrared spectroscopy and microscopic Raman spectroscopy, in addition to the image analysis. When performing the other analyses described above, only the particles contained in the liquid sample are analyzed.

[0032] When a sample is analyzed using dynamic image analysis device 100B, the sample containing particles is discharged into waste liquid container 5, and the user must collect the particles from the sample discharged into waste liquid container 5. Therefore, the user must perform the task of collecting the particles from the waste liquid in addition to the task related to dynamic image analysis. To collect the particles, for example, the user must pour the liquid sample into a funnel equipped with filter paper, separate the particles from the liquid, and collect them on the filter paper. Therefore, the user's task time may be extended.

[0033] [Analysis using a dynamic image analyzer according to an embodiment] Therefore, the dynamic image analysis device 100 according to this embodiment includes a collection unit 3 in a flow path through which analyzed particles flow. According to the dynamic image analysis device 100, particles of a liquid sample subjected to image analysis are collected in the collection unit 3. By using the dynamic image analysis device 100, a user can recover particles contained in a sample without performing an operation for collecting the particles. Therefore, the user's operation time can be shortened.

[0034] The following describes analysis of particle shapes using the dynamic image analyzer 100. The dynamic image analyzer 100 is used, for example, in measurements for intermittently detecting particles from a sample. The sample contains particles and a sample liquid.

[0035] A user introduces a liquid sample S1 containing particles into the sample introduction section 1. The liquid sample S1 introduced into the sample introduction section 1 is sucked by a pump 4, and introduced from the sample introduction section 1 into a cell 2. The liquid sample S1 flows continuously through a flow path 22 formed inside the cell 2.

[0036] When the liquid sample S1 flows through the flow path 22, the light source 6 irradiates the cell 2 with a light ray A1. The light ray A1 passes through a field lens (not shown) to become parallel light, and passes through a condenser lens (not shown) to be focused on a predetermined area in the cell 2. The predetermined area becomes the area to be photographed by the photographing unit 7. The light ray A2 that passes through the cell 2 passes through a lens 71 to be projected onto the photographing unit 7.

[0037] The photographing unit 7 photographs the cell 2 at a predetermined interval and acquires images of the particles P1 in the flow channel 22. The control device 8 processes the acquired images to analyze the shapes of the particles P1. The control device 8 displays data relating to the shapes of the particles P1 on a display.

[0038] The liquid sample S1 that has passed through the cell 2 is introduced into the collection section 3. Particles P2 contained in the liquid sample S1 are captured by the filter 33 of the collection section 3. The size of the captured particles varies depending on the pore size of the filter 33. The sample liquid and the particles that have passed through the filter 33 are discharged into a waste liquid container 5.

[0039] The dynamic image analysis device 100 collects particles contained in the sample after the image is captured by the collection unit 3. After the image of the sample is captured, the user can collect the particles collected by the collection unit 3 and provide them for other analyses. The other analyses are, for example, infrared spectroscopy, Raman spectroscopy, X-ray fluorescence analysis, mass spectrometry, microscopic infrared spectroscopy, and microscopic Raman spectroscopy. According to the dynamic image analysis device 100, particles are collected in parallel with the dynamic image analysis, so that the user can complete the work related to the image analysis and the work related to the particle collection at the same time. Therefore, by using the dynamic image analysis device 100, the user does not need to perform the work for collecting particles separately from the dynamic image analysis, so that the user's work time required for collecting the particles can be shortened.

[0040] In the dynamic image analysis device 100 shown in FIG. 1, the collection unit 3 is provided in the flow path between the cell 2 and the pump 4, but the location of the collection unit 3 is not important as long as it is in the flow path downstream of the cell 2 and upstream of the waste liquid container 5.

[0041] Incidentally, it is preferable to provide the collection unit 3 between the cell 2 and the pump 4 rather than after the pump 4, for the following two reasons.

[0042] The first point is that excessive pressure can be prevented from being applied to the filter 33 of the collection unit 3 and the entire dynamic image analysis device 100. If the collection unit 3 is provided at a stage subsequent to the pump 4, the liquid sample S1 pushed out from the pump 4 is introduced into the collection unit 3, so that the liquid sample S1 passes through the collection unit 3 under positive pressure. If particles are pushed out against the filter 33, a plurality of particles may concentrate in a local area of ​​the filter 33, causing the filter 33 to become clogged. In such a case, the holes of the filter 33 may become blocked, and the pressure applied to the entire dynamic image analysis device 100 may become excessive. On the other hand, by providing the collection unit 3 at a stage prior to the pump 4, negative pressure is applied to the liquid sample S1 when it passes through the filter 33. While the range of the magnitude of the positive pressure is unlimited, the magnitude of the negative pressure is limited, and the pressure cannot be reduced below a predetermined pressure. For this reason, if the pressure applied to the entire dynamic image analysis apparatus 100 becomes negative when the liquid sample S1 passes through the filter 33, it is possible to avoid a situation in which excessive pressure is applied to the filter 33. As a result, it is possible to prevent a plurality of particles from concentrating in a localized area on the filter 33. Furthermore, if the pores of the filter 33 become clogged with particles, the particles are likely to be carried to another pore, so it is possible to prevent excessive pressure from being applied to the entire dynamic image analysis apparatus 100.

[0043] The second point is that it is possible to prevent contamination of particles other than those to be analyzed. In the pump 4, particles originating from a sample of an analysis performed prior to the current analysis may remain. If the collector 3 is provided after the pump 4, the collector 3 may collect particles remaining in the pump 4 together with particles of the sample. If the remaining particles are contaminated in this way, the analytical accuracy may deteriorate when the collected particles are used for another analysis. By providing the collector 3 between the cell 2 and the pump 4, it is possible to prevent contamination of particles originating from other samples. By preventing particle contamination, it is possible to improve the analytical accuracy when the collected particles are used for another analysis.

[0044] In the above-described embodiment, the collection unit 3 has one filter, but the collection unit 3 may have multiple filters. The pore size of the multiple filters in the collection unit 3 may be different for each filter. By having multiple filters with different pore sizes, the collection unit 3 can prevent the filters from clogging. Furthermore, the size of the particles collected by these filters differs for each filter, so that the type of particle can be estimated for each particle size.

[0045] Specifically, for example, it is assumed that the collection unit 3 has, in order from the cell 2 side, a first filter with a pore size of 300 μm, a second filter with a pore size of 100 μm, and a third filter with a pore size of 20 μm. When analyzing using a dynamic image analyzer 100 equipped with this collection unit 3, particles with a particle size of 300 μm or more are collected by the first filter. Among the particles that pass through the first filter, particles with a particle size of 100 μm or more are collected by the second filter. Among the particles that pass through the second filter, particles with a particle size of 20 μm or more are collected by the third filter. Therefore, since particles with a particle size of 300 μm or more do not reach the second filter and the third filter, clogging of the filters can be prevented by using the collection unit 3 having a plurality of filters with different pore sizes. In addition, since the particles collected by the first filter, the second filter, and the third filter can be subjected to separate analyses, the type of particle can be estimated for each particle size.

[0046] [Variations] When the collection unit 3 having the filter 33 is provided between the cell 2 and the pump 4, the flow resistance may increase depending on the pore size and material of the filter 33, and the flow rate per unit time may decrease. In that case, the time required for image analysis may become longer, which may be inconvenient for the user. Furthermore, the decrease in the flow rate per unit time may cause the same particle to be detected multiple times, which may reduce the accuracy of the analysis.

[0047] Therefore, in a modified example of the dynamic image analyzer according to the present embodiment, a configuration is provided that allows switching between a state in which the sample after image analysis passes through the collection section and a state in which the sample does not pass through the collection section. With this configuration, the timing for taking an image while the liquid sample is flowing and the timing for collecting the particles can be separated, and a decrease in the flow rate of the sample during imaging can be prevented.

[0048] 3 shows a dynamic image analyzer 100C which is a modified example of the dynamic image analyzer according to the present embodiment. The dynamic image analyzer 100C includes a sample introduction section 1, a cell 2, a collection section 3, a pump 4, a waste liquid container 5, a light source 6, an imaging section 7, a control device 8, a switching valve 9, and a drive section 10.

[0049] The switching valve 9 is connected downstream of the cell 2 and switches the destination of the sample discharged from the cell 2. The switching valve 9 can switch between a state in which the sample discharged from the cell 2 flows to the pump 4 via the collection unit 3 (hereinafter referred to as a first state), and a state in which the sample flows to the pump 4 without passing through the collection unit 3 (hereinafter referred to as a second state).

[0050] The driving unit 10 is configured to be controlled by the control device 8 and to drive the switching valve 9. Specifically, the driving unit 10 controls the switching valve 9 to switch between a first state and a second state. The driving unit 10 includes, for example, a stepping motor.

[0051] The control device 8 controls the switching valve 9 to be in the second state when imaging is being performed while the sample is flowing. Also, the control device 8 controls the switching valve 9 to be in the first state so that the sample passes through the collection unit 3 after imaging is completed. By switching between the first state and the second state in this manner, the control device 8 collects particles by the collection unit 3 while preventing the time required to image the sample from becoming too long. The control of the switching valve 9 may be performed by a user.

[0052] The control device 8 may switch between the first state and the second state when particles are detected by image analysis. For example, assume a case where a liquid sample that is assumed not to contain particles is analyzed. In this case, when particles are detected, the control device 8 controls the switching valve 9 so that the second state is changed to the first state. According to this configuration, the dynamic image analysis device 100C does not pass the liquid sample through the collection unit 3 until particles are detected, so that it is possible to prevent the analysis time from being extended due to the liquid sample passing through the collection unit 3. In addition, when particles are detected, the particles contained in the liquid sample are collected in the collection unit 3, so that the user can collect the particles and provide them for another analysis without performing a separate task of collecting the particles.

[0053] As another modification, the dynamic image analyzer may include a sample loop 11 into which the liquid sample that has passed through the cell 2 is temporarily introduced between the cell 2 and the switching valve 9. Fig. 4 shows a dynamic image analyzer 100D, which is another modification of the dynamic image analyzer according to this embodiment. The dynamic image analyzer 100D includes a sample introduction section 1, a cell 2, a collection section 3, a pump 4, a waste liquid container 5, a light source 6, an imaging section 7, and a control device 8, as well as a sample loop 11.

[0054] By providing a sample loop 11 with a volume sufficient for the sample to be analyzed, the dynamic image analyzer 100D can complete imaging of the sample that has passed through the cell 2 before it reaches the collection section 3. As a result, it is possible to prevent the filter from clogging during the period in which the sample is being imaged, and to prevent fluctuations in the flow rate per unit time.

[0055] The sample loop 11 may be configured, for example, by a long flow path, as long as it is capable of temporarily storing the liquid sample that has passed through the cell 2. Although the capacity of the sample loop 11 is preferably larger than the liquid sample to be analyzed, the capacity may be smaller than the volume of the sample to be analyzed, since temporarily storing the sample after passing through the cell 2 can delay the sample's arrival at the collection unit 3 and prevent the filter of the collection unit 3 from clogging while the sample is being photographed.

[0056] [Aspects] It will be appreciated by those skilled in the art that the exemplary embodiments described above are examples of the following aspects.

[0057] (Item 1) In one embodiment, a dynamic image analysis device is a dynamic image analysis device that analyzes particles contained in a liquid sample, and may include a cell through which the liquid sample passes, an imaging unit that takes images of the particles passing through the cell, and a collection unit that is positioned downstream of the cell and separates the particles from the liquid and collects them.

[0058] The dynamic image analysis device described in paragraph 1 provides a technique for collecting particles of a sample subjected to image analysis.

[0059] (Item 2) The dynamic image analyzer according to item 1 may further include a pump that aspirates the liquid sample in the cell, and the collection unit may be disposed between the cell and the pump.

[0060] The dynamic image analyzer described in paragraph 2 provides a technique for collecting particles of a sample that has been subjected to image analysis on a filter. The dynamic image analyzer described in paragraph 2 also provides a technique for preventing particles remaining in the pump flow path from contaminating the sample.

[0061] (Clause 3) The dynamic image analysis device described in paragraph 2 may further include a switching valve switchable between a first state in which the liquid sample that has passed through the cell flows in and flows out to the pump via the collection section, and a second state in which the liquid sample flows out to the pump without passing through the collection section.

[0062] According to the dynamic image analyzer described in the third aspect, a technique is provided that allows switching between a state in which the analyzed sample passes through the collection section and a state in which it does not pass through. Depending on the pore size and material of the filter, the flow rate of the sample per unit time may be reduced by providing a collection section between the pump and the cell. Furthermore, the flow rate may be reduced by particles clogging the filter holes of the collection section. As a result, the amount of sample per unit time when photographing while flowing the sample is reduced, and the time required for image analysis is extended. Furthermore, sufficient analysis accuracy may not be obtained by detecting the same particle multiple times. By controlling the switching valve, the liquid sample is prevented from flowing into the collection section while photographing while flowing the liquid sample, thereby preventing the time required for photographing the liquid sample from being extended.

[0063] (Clause 4) The dynamic image analysis device described in paragraph 3 further includes a control unit that analyzes the image captured by the imaging unit, and a drive unit that drives the switching valve, and the control unit may control the switching valve via the drive unit to be in the first state or the second state based on a result of analyzing the image.

[0064] According to the dynamic image analysis device described in the fourth aspect, a technique is provided for collecting particles that satisfy predetermined conditions according to the results of image analysis.

[0065] (Item 5) The dynamic image analysis device described in items 1 to 4 may further include a sample loop into which the liquid sample that has passed through the cell is introduced, and the sample loop may be disposed between the cell and the collection section.

[0066] According to the dynamic image analysis device described in the fifth aspect, a technique is provided for photographing a sample without reducing the flow rate of the sample per unit time in the cell, even when a collection section having a filter is provided.

[0067] (Item 6) In the dynamic image analysis device described in any one of Items 1 to 5, the collection section may have a first filter and a second filter having a pore size different from that of the first filter.

[0068] According to the dynamic image analyzer described in paragraph 6, by collecting particles using a combination of multiple types of filters, it is possible to prevent the filters from clogging. In addition, by subjecting particles separated according to size to other analyses, it is possible to infer the type of particle according to its size.

[0069] The embodiments disclosed herein should be considered to be illustrative and not restrictive in all respects. The scope of the present disclosure is indicated by the claims, not by the description of the above-mentioned embodiments, and is intended to include all modifications within the meaning and scope of the claims. In addition, it is intended that each technology in the embodiments can be implemented alone or, if necessary, in combination with other technologies in the embodiments as far as possible. [Explanation of symbols]

[0070] 1 sample introduction section, 2 cell, 3 collection section, 4 pump, 5 waste liquid container, 6 light source, 7 imaging section, 8 control device, 9 switching valve, 10 drive section, 11 sample loop, 21, 31 housing, 22, 32 flow path, 33 filter, 71 lens, 72 imaging element, 73 signal processing circuit, 81 controller, 82 processor, 83 memory, 84 input / output I / F, 85 input section, 86 output section, 100, 100B, 100C, 100D dynamic image analysis device.

Claims

1. A dynamic image analyzer for analyzing particles contained in a liquid sample, comprising: a cell through which the liquid sample passes; An imaging unit that captures an image of the particles passing through the cell; a collection unit disposed downstream of the cell for separating the particles from the liquid and collecting the particles.

2. a pump for aspirating the liquid sample in the cell; The dynamic image analyzer according to claim 1 , wherein the collector is disposed between the cell and the pump.

3. 3. The dynamic image analysis device of claim 2, further comprising a switching valve switchable between a first state in which the liquid sample that has passed through the cell flows in and flows out to the pump via the collection section, and a second state in which the liquid sample flows out to the pump without passing through the collection section.

4. A control unit that analyzes the image captured by the imaging unit; A drive unit that drives the switching valve, The dynamic image analysis device according to claim 3 , wherein the control unit controls the switching valve via the drive unit so as to set the switching valve to the first state or the second state based on a result of analyzing the image.

5. A sample loop into which the liquid sample that has passed through the cell is introduced, 5. The dynamic image analyzer according to claim 1, wherein the sample loop is disposed between the cell and the collector.

6. 3. The dynamic image analyzer according to claim 1, wherein the collection unit has a first filter and a second filter having a pore size different from that of the first filter.

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