Cosmetic

Abstract

To provide a cosmetic that gives a pleasant sensation during use.SOLUTION: A cosmetic comprises: (A) polyoxyethylene sorbitan fatty acid ester; (B) an N-acylmethyltaurate salt; (C) a linear higher alcohol; (D) a pyrimidylpyrazole compound having a specific structure or a salt thereof; (E) an oil component; and (F) water.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to cosmetics. Specifically, the present invention relates to a cosmetic comprising a pyrimidylpyrazole compound or a salt thereof.

Background Art

[0002] Skin spots, freckles and other pigmentations occur due to abnormal hormones or ultraviolet stimulation, which enhances melanin production in epidermal pigment cells and causes excessive deposition of melanin on the epidermis. For the purpose of preventing or improving such abnormal deposition of melanin pigments, whitening agents are incorporated into cosmetics. Although various components are known as whitening agents incorporated into cosmetics, in recent years, pyrimidylpyrazole compounds are also known as useful whitening agents (for example, Patent Document 1).

[0003] Water-in-oil emulsion cosmetics are widely used as a base for external skin preparations including skin cosmetics because of their fresh feeling in use. However, emulsions are inherently unstable and are known to cause phenomena such as creaming, aggregation, or coalescence when left for a long time. In conventional emulsions and creams, carboxyvinyl polymer, which is a general water-soluble thickener, etc. were blended to ensure stability over time. However, when a large amount of water-soluble thickener was blended, it was difficult to eliminate stickiness, elongation weight, stickiness, sagging, etc. at the time of application. Therefore, a cosmetic having no sticky feeling and a fresh and penetrating feeling has been proposed by combining polyoxyethylene fatty acid sorbitan, a specific surfactant, and a higher alcohol (for example, Patent Document 2).

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Summary of the Invention

[0005] The inventors have surprisingly found that by using a cosmetic containing a pyrimidylpyrazole compound or a salt thereof in combination with polyoxyethylene fatty acid sorbitan, N-acylmethyltaurine salt and linear higher alcohol, an excellent feeling in use can be achieved. The present invention is based on these findings.

[0006] According to the present invention, the following inventions are provided. [1] A cosmetic comprising (A) polyoxyethylene fatty acid sorbitan, (B) N-acylmethyltaurine salt, (C) linear higher alcohol, (D) a pyrimidylpyrazole compound represented by formula (1) or a salt thereof, (E) an oil component, and (F) water.

Chem.

[0007] According to the present invention, a cosmetic excellent in usability can be provided. In particular, it can give a smooth feeling during application and impart a firm feeling to the skin after application. DETAILED DESCRIPTION OF THE INVENTION

[0008] The present invention relates to a cosmetic comprising (A) polyoxyethylene fatty acid sorbitan, (B) N-acylmethyl taurine salt, (C) linear higher alcohol, (D) a pyrimidyl pyrazole compound having a specific structure or a salt thereof, (E) an oil component, and (F) water.

[0009] (A) Polyoxyethylene fatty acid sorbitan The cosmetic according to the present invention comprises (A) polyoxyethylene fatty acid sorbitan. The component (A) has a structure in which a linear saturated fatty acid, for example, stearic acid, palmitic acid, myristic acid, etc. is bonded to polyoxyethylene, and the fatty acid moiety preferably has 14 to 18 carbon atoms. The component (A) is more preferably polyoxyethylene sorbitan monostearate. Examples of the component (A) include, but are not limited to, POE(20)sorbitan stearate (polysorbate 60, such as NIKKOL TS-10V, manufactured by Nikko Chemicals Co., Ltd.), POE(20)sorbitan myristate, POE(20)sorbitan palmitate (such as NIKKOL TP-10V, manufactured by Nikko Chemicals Co., Ltd.), POE(6)sorbitan stearate (such as NIKKOL TS-106V, manufactured by Nikko Chemicals Co., Ltd.), POE(6)sorbitan myristate, and POE(6)sorbitan palmitate.

[0010] One or more kinds of the component (A) can be blended. The blending amount of the component (A) is preferably 0.05 to 7% by mass, more preferably 0.1 to 1.5% by mass, and still more preferably 0.2 to 1.0% by mass based on the total amount of the cosmetic.

[0011] (B) N-acylmethyltaurine salt The cosmetic according to the present invention contains (B) N-acylmethyltaurine salt. As the component (B), N-acyltaurine salts having an acyl group with 14 to 22 carbon atoms are preferred. Specifically, N-stearoyl methyl taurine salt, N-palmitoyl methyl taurine salt, and N-myristoyl methyl taurine salt can be mentioned, and N-stearoyl methyl taurine salt is preferred. Preferred counter ions include sodium, potassium, triethanolamine, etc. The component (B) is preferably N-stearoyl methyl taurine sodium.

[0012] One or more kinds of the component (B) can be blended. The blending amount of the component (B) is preferably 0.005 to 2% by mass, more preferably 0.01 to 1% by mass, and still more preferably 0.05 to 0.5% by mass based on the total amount of the cosmetic.

[0013] In order to further improve the stability of the cosmetic, the molar ratio of component (A) to component (B) is preferably (A):(B)=1:0.05 to 1:1.5, more preferably (A):(B)=1:0.1 to 1:1.

[0014] (C) Linear higher alcohol The cosmetic according to the present invention comprises (C) a linear higher alcohol. Component (C) is preferably a higher alcohol having 14 to 22 carbon atoms with a linear saturated alkyl group. Examples of component (C) include myristyl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, etc. Component (C) preferably contains one or more of cetyl alcohol, stearyl alcohol, and behenyl alcohol.

[0015] Component (C) can be blended in one kind or two or more kinds. The blending amount of component (C) is preferably 0.1 to 7% by mass, more preferably 0.2 to 5% by mass, still more preferably 0.3 to 3% by mass based on the total amount of the cosmetic.

[0016] (D) Pyrimidylpyrazole compound or a salt thereof The cosmetic according to the present invention comprises (D) a pyrimidylpyrazole compound represented by formula (1) or a salt thereof. [Chemical formula] In the formula, R 1 , R 3 , R 4 and R 6 are each independently a C 1-3 alkyl group, specifically a methyl group, an ethyl group, an n-propyl group, an isopropyl group, or a cyclopropyl group, preferably a methyl group or an ethyl group, more preferably a methyl group. R 2 and R 5 are each independently a hydrogen atom or a C 1-3It is an alkyl group, specifically, a hydrogen atom, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, or a cyclopropyl group, preferably a hydrogen atom, a methyl group or an ethyl group, and more preferably a hydrogen atom.

[0017] The component (D) may be a salt of the pyrimidylpyrazole compound represented by the formula (1). The type of the salt is not particularly limited as long as it is a pharmacologically acceptable salt, and it may be an inorganic salt or an organic salt. Examples of the salt include hydrochloride, hydrobromide, sulfate, phosphate, acetate, propionate, citrate, lactate, oxalate, maleate, fumarate, tartrate, methanesulfonate, and the like. The component (D) is preferably dimethylpyrazolyldimethylpyrimidine hydrochloride.

[0018] One or more kinds of the component (D) can be blended. The blending amount of the component (D) is preferably 0.1 to 1.5% by mass, more preferably 0.3 to 1.3% by mass, and still more preferably 0.4 to 1.2% by mass based on the total amount of the cosmetic.

[0019] (E) Oil component The cosmetic according to the present invention contains the (E) oil component. Examples of the component (E) include silicone oil, hydrocarbon oil, ester oil, etc. In the present invention, the component (E) does not include the component (C).

[0020] Examples of the silicone oil include linear polysiloxane (e.g., dimethicone, diphenylsiloxyphenyltrimethicone, diphenylpolysiloxane, etc.), cyclic polysiloxane (e.g., octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, etc.), silicone resin forming a three-dimensional network structure, silicone rubber, various modified polysiloxanes (amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc.), acrylic silicones, etc., and linear polysiloxane is preferred.

[0021] Examples of the hydrocarbon oil include isododecane, isohexadecane, isoparaffin, mineral oil (liquid paraffin), ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, hydrogenated polydecene, and the like.

[0022] Examples of ester oils include octyl octanoate, nonyl nonanoate, cetyl octanoate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, ethylhexyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, tripropylene glycol pivalate, diisostearyl malate, glycerin di-2-heptylundecanoate, glycerin diisostearate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythrityl tetraethylhexanoate, glycerin tri-2-ethylhexanoate, glycerin trioctanoate, glycerin triisopalmitate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate-2-ethylhexyl palmitate, glycerin trimyristate, glyceride di-2-heptylundecanoate, methyl ester of castor oil fatty acid, oleyl oleate, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, 2-octyldodecyl N-lauroyl-L-glutamate, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, triethyl citrate, cetyl ethylhexanoate, phytosteryl macadamia nut fatty acid, and the like.

[0023] Component (E) can be blended in one or more kinds. The blending amount of component (E) is preferably 1 to 40% by mass, more preferably 5 to 20% by mass, based on the total amount of the cosmetic.

[0024] (F) Water The cosmetic according to the present invention comprises (F) water. As the water, water used in cosmetics, quasi-drugs, etc. can be used, for example, purified water, ion-exchanged water, tap water, etc. can be used. The blending amount of water is preferably 65 to 85% by mass, more preferably 75 to 85% by mass, based on the total amount of the cosmetic according to the present invention.

[0025] The cosmetic according to the present invention may further contain (G) glycerin monoalkyl ester, glycerin monoalkyl ether, sorbitan monoalkyl ester, sorbitan monoalkyl ether, sterols, or branched higher alcohols. The component (G) has the same function as the component (C), but by further containing the component (G), the stability can be further improved. One or more kinds of the component (G) can be blended. The blending amount of the component (G) is preferably 3% by mass or less, more preferably 0.05 to 1.5% by mass, still more preferably 0.1 to 0.8% by mass, based on the total amount of the cosmetic. Also, the blending amount of the component (G) is preferably 30% or less based on the total number of moles of the component (C) and the component (G).

[0026] The cosmetic according to the present invention may further contain (H) an organic acid or a salt thereof. Examples of the component (H) include citric acid, amino acids, ascorbic acid or its derivatives, salicylic acid or its derivatives, tranexamic acid or its derivatives, glycolic acid or its derivatives, pyrrolidonecarboxylic acid, sodium lactate, ellagic acid, glycyrrhizic acid, edetic acetic acid, etc., and salts thereof may also be used. One or more kinds of the component (H) can be blended. The blending amount of the component (H) is preferably 0.01 to 2% by mass, more preferably 0.05 to 0.5% by mass.

[0027] In addition to the above components, the cosmetic of the present invention can contain optional components commonly used in cosmetics and pharmaceuticals. Examples of the optional components include, but are not limited to, humectants, lower alcohols, sequestering agents, neutralizing agents, pH adjusters, antioxidants, preservatives, drugs, ultraviolet absorbers, powder components, fragrances, etc. As long as the effects of the present invention can be achieved, one or more of them can be formulated. In addition, the cosmetic according to the present invention preferably does not contain a water-soluble thickener, or if it contains one, the content is preferably less than 0.1% by mass.

[0028] The dosage form of the cosmetic according to the present invention is not particularly limited, but it is preferably in the form of an oil-in-water type emulsified cosmetic. Since the external phase that first touches the skin of the oil-in-water type emulsified cosmetic is an aqueous phase, it gives a fresh feeling to the skin and makes it possible to more vividly feel the effects of the present invention.

[0029] Examples of the cosmetic according to the present invention include, but are not limited to, skin care cosmetics (such as lotion, emulsion, cream, essence, pack, mask, etc.), makeup cosmetics (such as foundation, makeup base, etc.), skin cleansers (such as facial wash, makeup remover, etc.), sunscreen cosmetics, ointments, etc. It should be noted that these forms are merely illustrative, and the cosmetic according to the present invention is not limited to these forms.

[0030] The method of emulsification for the cosmetic of the present invention is not particularly limited and can be produced according to conventional methods.

Examples

[0031] The present invention will be specifically described based on the following examples, but the present invention is not limited to these examples. Unless otherwise specified, the content is expressed as mass% based on the total amount.

[0032] [Examples 1 to 3 and Comparative Example 1] Oil-in-water type emulsified cosmetics of Examples 1 to 3 and Comparative Example 1 were prepared with the formulations shown in Table 1.

Table 1

[0033] [Usability Evaluation] The cosmetic prepared above was applied to the skin by a professional panel, and scored according to the following criteria for the "smoothness" during application and the "firmness" of the skin after application, and evaluated based on the average score of 5 professional panelists. The results obtained were described in Table 1. +2: The "smoothness" / "firmness" can be felt more than that of the cosmetic of Comparative Example 1. +1: The "smoothness" / "firmness" can be felt slightly more than that of the cosmetic of Comparative Example 1. 0: The "smoothness" / "firmness" is at the same level as that of the cosmetic of Comparative Example 1. -1: The cosmetic of Comparative Example 1 can be felt to have slightly more "smoothness" / "firmness". -2: The cosmetic of Comparative Example 1 can be felt to have more "smoothness" / "firmness".

Claims

1. (A) Polyoxyethylene fatty acid sorbitan, (B) N-acylmethyltaurine salt, (C) Linear higher alcohol, (D) A pyrimidylpyrazole compound represented by formula (1) or a salt thereof, (E) Oil component, and (F) Water A cosmetic composition comprising the same. 【Chemical 1】 (In the formula, R １ , R ３ , R ４ and R ６ are each independently a C １－３ alkyl group, and R ２ and R ５ each independently represents a hydrogen atom or a C １－３ alkyl group).

2. R ２ and R ５ The cosmetic according to claim 1, wherein R and R are hydrogen atoms.

3. R １ 、 R ３ 、 R ４ and R ６ are methyl groups, The cosmetic according to claim 1 or 2.

4. The cosmetic composition according to claim 1 or 2, further comprising (G) glycerin monoalkyl ester, glycerin monoalkyl ether, sorbitan monoalkyl ester, sorbitan monoalkyl ester, sterols, or branched higher alcohol.

5. The cosmetic composition according to claim 1 or 2, further comprising (H) an organic acid or a salt thereof.

6. The cosmetic composition according to claim 1 or 2, wherein the component (A) is polyoxyethylene sorbitan monostearate.

7. The cosmetic composition according to claim 1 or 2, wherein the component (B) is sodium N-stearoylmethyltaurine.

8. The cosmetic composition according to claim 1 or 2, wherein the content of the component (D) is 0.1 to 1.5% by mass based on the total amount of the cosmetic composition.

9. The cosmetic composition according to claim 1 or 2, wherein the molar ratio of the component (A) to the component (B) is (A):(B) = 1:0.05 to 1:1.

5.

10. The cosmetic composition according to claim 1 or 2, which is an oil-in-water type emulsified cosmetic.

Images