Cosmetic

Abstract

To provide a cosmetic with excellent usability.SOLUTION: A cosmetic comprises (A) polyoxyalkylene dialkyl dimer diol ether, (B) a pyrimidylpyrazole compound having a specific structure, and (C) water.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to cosmetics. Specifically, the present invention relates to a cosmetic comprising a pyrimidylpyrazole compound or a salt thereof.

Background Art

[0002] Cosmetics include various dosage forms such as lotions, emulsions, creams, etc. Among them, lotions are one of the essential items for basic makeup. In addition to water and water-soluble substances of moisturizing components, various surfactants are formulated in lotions in order to stably incorporate water-insoluble substances such as fragrances, oils, and oil-soluble drugs. For example, it has been proposed to formulate an alkylene oxide derivative having a specific structure as a surfactant (for example, Patent Document 1).

[0003] Skin spots, freckles, and other pigmentations are caused by abnormal hormones or ultraviolet stimulation, which enhances melanin production in epidermal pigment cells and causes excessive deposition of melanin on the epidermis. For the purpose of preventing and improving such abnormal deposition of melanin pigment, whitening agents are formulated in cosmetics. Although various components are known as whitening agents, in recent years, pyrimidylpyrazole compounds are also known as useful whitening agents (for example, Patent Document 2).

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Summary of the Invention

[0005] According to the studies by the present inventors, it has been found that when a pyrimidylpyrazole compound is used in cosmetics, it tends to cause stickiness. The present inventors have surprisingly found that excellent usability can be achieved by using a cosmetic containing a combination of a pyrimidylpyrazole compound or a salt thereof and a polyoxyalkylene dialkyldimer diol ether. The present invention is based on these findings.

[0006] According to the present invention, the following inventions are provided. [1] A cosmetic comprising (A) a polyoxyalkylene dialkyldimer diol ether, (B) a pyrimidylpyrazole compound represented by formula (1), and (C) water. [Chemical formula] (In the formula, R 1 , R 3 , R 4 and R 6 are each independently a C 1-3 alkyl group, and R 2 and R 5 are each independently a hydrogen atom or a C 1-3 alkyl group) [2] The cosmetic according to [1], wherein R 2 and R 5 are hydrogen atoms. [3] The cosmetic according to [1] or [2], wherein R 1 , R 3 , R 4 and R 6 are methyl groups. [4] The cosmetic according to any one of [1] to [3], wherein the component (A) is PEG / polybutylene glycol-44 / 15 methyl ether hydrogenated dimer linoleyl. [5] The cosmetic according to any one of [1] to [4], wherein the blending amount of the component (A) is 0.01 to 1% by mass based on the total amount of the cosmetic. The cosmetic according to any one of [1] to [5], wherein the blending amount of the component (B) is 0.01 to 1.5% by mass based on the total amount of the cosmetic. The cosmetic according to any one of [1] to [6], wherein the blending ratio of the component (A) to the component (B) is (A):(B) = 1:0.2 to 1:60 in terms of mass ratio. The cosmetic according to any one of [1] to [7], wherein the blending amount of the component (D) oil is 0% by mass or more and 1% by mass or less based on the total amount of the cosmetic. The cosmetic according to any one of [1] to [8], which is an aqueous cosmetic.

[0007] According to the present invention, a cosmetic having excellent usability can be provided. In particular, it is fresh during application and can suppress stickiness after application. Detailed description of the invention

[0008] The present invention relates to a cosmetic comprising (A) polyoxyalkylene dialkyldimer diol ether, (B) a pyrimidylpyrazole compound having a specific structure, and (C) water.

[0009] (A) Polyoxyalkylene dialkyldimer diol ether The cosmetic according to the present invention comprises (A) polyoxyalkylene dialkyldimer diol ether.

[0010] The component (A) is preferably represented by the following formula. Z-{O-[(AO) a -(EO) b -R} 2 In the formula, Z is a residue obtained by removing a hydroxyl group from a dimer diol, preferably a dimer diol residue having 24 to 48 carbon atoms. AO is an oxyalkylene group having 3 or 4 carbon atoms, preferably an oxypropylene group or an oxybutylene group, more preferably an oxybutylene group. The addition form of the oxyalkylene group with 3 or 4 carbon atoms and the oxyethylene group is a block, and the addition order is preferably bonded in the order of AO and EO to the dimer diol. a and b are the average number of moles of addition of the oxyalkylene group and the oxyethylene group, respectively, where 1 ≦ 2×a ≦ 150 and 1 ≦ 2×b ≦ 150. Preferably, 2 ≦ 2×a ≦ 70 and 5 ≦ 2×b ≦ 120. More preferably, 2 ≦ 2×a ≦ 50 and 10 ≦ 2×b ≦ 100. The ratio of the oxyethylene group to the total of the oxyalkylene group and the oxyethylene group is 10 to 99% by mass, preferably 20 to 70% by mass. Each R is independently a hydrocarbon group having 1 to 4 carbon atoms, preferably a methyl group or an ethyl group.

[0011] Component (A) is preferably polyoxyethylene polyoxybutylene dimethyl dimer diol ether, more preferably PEG / polybutylene glycol-44 / 15 methyl ether hydrogenated dimer dilinoleyl.

[0012] One or more kinds of component (A) can be blended. The blending amount of component (A) is preferably 0.01 to 1% by mass, more preferably 0.05 to 0.8% by mass, and even more preferably 0.1 to 0.6% by mass based on the total amount of the cosmetic.

[0013] (B) Pyrimidylpyrazole compound or a salt thereof The cosmetic according to the present invention comprises a pyrimidylpyrazole compound represented by the formula (1) or a salt thereof as component (B).

Chem.

[0014] (Component B) may be a salt of the pyrimidylpyrazole compound represented by formula (1). The type of the salt is not particularly limited as long as it is a pharmacologically acceptable salt, and it may be an inorganic salt or an organic salt. Examples of the salt include hydrochloride, hydrobromide, sulfate, phosphate, acetate, propionate, citrate, lactate, oxalate, maleate, fumarate, tartrate, methanesulfonate, and the like. (Component B) is preferably dimethylpyrazolyldimethylpyrimidine hydrochloride.

[0015] (Component B) can be blended in one kind or two or more kinds. The blending amount of (Component B) is preferably 0.01 to 1.5% by mass, more preferably 0.1 to 1% by mass, still more preferably 0.3 to 0.6% by mass, based on the total amount of the cosmetic.

[0016] The blending ratio of (Component A) and (Component B) is preferably (A):(B) = 1:0.2 to 1:60, more preferably (A):(B) = 1:0.5 to 1:30, still more preferably (A):(B) = 1:1 to 1:12, and even more preferably (A):(B) = 1:2 to 1:3.5, by mass ratio.

[0017] (C) Water The cosmetic according to the present invention contains (C) water. As the water, water used in cosmetics, quasi-drugs, etc. can be used. For example, purified water, ion-exchanged water, tap water, etc. can be used. The blending amount of water is preferably 50 to 80% by mass based on the total amount of the cosmetic according to the present invention.

[0018] (D) Oil The cosmetic according to the present invention may contain (D) oil. From the viewpoint of stability, it is preferable that the blending amount of (D) oil is small. The blending amount of the oil is preferably 0% by mass or more and 1% by mass or less, more preferably 0% by mass or more and 0.1% by mass or less, based on the total amount of the cosmetic. It is also a preferred embodiment of the present invention that the cosmetic according to the present invention does not contain oil (0% by mass). Examples of the (D) component include silicone oil, hydrocarbon oil, higher fatty acid, higher alcohol, ester oil, liquid oil, solid oil, semi-solid oil, etc.

[0019] In addition to the above components, optional components usually used in cosmetics and pharmaceuticals can be blended in the cosmetic of the present invention. Examples of the optional components include humectants, lower alcohols, thickeners, sequestering agents, neutralizing agents, pH adjusters, antioxidants, preservatives, drugs, ultraviolet absorbers, powder components, fragrances, etc. As long as the effects of the present invention are exhibited, one kind or two or more kinds can be blended.

[0020] The cosmetic according to the present invention is preferably an aqueous cosmetic. In particular, the effects of the present invention are preferably exhibited when it is made into a transparent or semi-transparent aqueous cosmetic such as lotion. The viscosity of the cosmetic according to the present invention is not limited, but is usually 1000 mPa·s or less, particularly preferably 500 mPa·s or less, which is preferable in terms of skin affinity. In the present invention, "transparent or translucent" means that the L value in the Lab color system (Hunter Lab system) of the cosmetic is 50 or more. The L value represents the transparency when the transparency of purified water is set to 100 and the case where there is no light transmission is set to 0. That is, the closer the L value is to 100, the higher the transparency. The L value can be measured using, for example, a color difference meter (such as Spectro color meter SE2000 (manufactured by Nippon Electric Shokai Co., Ltd.) or COLOR-EYE 7000A (manufactured by Gretag Macbeth)).

[0021] Examples of the cosmetic according to the present invention include, for example, skin care cosmetics (such as lotion, essence, pack, etc.), skin cleansing agents (such as facial wash, makeup remover, etc.). Note that these forms are merely examples, and the cosmetics according to the present invention are not limited to these forms.

[0022] The cosmetic of the present invention can be produced according to a conventional method. When the cosmetic according to the present invention is an emulsion cosmetic, the emulsification method is not particularly limited.

Example

[0023] The present invention will be specifically described based on the following examples, but the present invention is not limited to these examples. Unless otherwise specified, the content is shown as mass% based on the total amount.

[0024] [Examples 1 to 3 and Comparative Examples 1 and 2] Aqueous cosmetics of Examples 1 to 3 and Comparative Examples 1 and 2 were prepared with the formulations shown in Table 1.

Table 1

[0025] The cosmetics prepared above were applied to the skin by 10 professional panelists, and the "freshness" during application and the "non-stickiness" after application were evaluated. Based on the evaluations of each professional panelist, the determination was made according to the following criteria. The results obtained were as shown in Table 1. [Freshness] A: Seven or more out of ten people answered that they felt freshness. B: Five or six out of ten people answered that they felt freshness. C: Three or four out of ten people answered that they felt freshness. D: Two or fewer out of ten people answered that they felt freshness. [Absence of stickiness] A: Seven or more out of ten people answered that there was no stickiness. B: Five or six out of ten people answered that there was no stickiness. C: Three or four out of ten people answered that there was no stickiness. D: Two or fewer out of ten people answered that there was no stickiness.

Claims

Claim 1 (A) Polyoxyalkylene dialkyl dimer diol ether, (B) A pyrimidylpyrazole compound represented by formula (1) or a salt thereof, and (C) Water A cosmetic composition comprising the same. 【Chemical 1】 (In the formula, R １ 、R ３ 、R ４ and R ６ are each independently a C １－３ alkyl group, and R ２ and R ５ are each independently a hydrogen atom or a C １－３ alkyl group). Claim 2 R ２ and R ５ The cosmetic according to claim 1, wherein R and R are each a hydrogen atom. Claim 3 R １ 、 R ３ 、 R ４ and R ６ are methyl groups, the cosmetic according to claim 1 or 2. Claim 4 (A) The component is PEG / polybutylene glycol-44 / 15 methyl ether hydrogenated dimer dilinoleyl, the cosmetic composition according to claim 1 or 2. Claim 5 (A) The content of the component is 0.01 to 1% by mass based on the total amount of the cosmetic composition, the cosmetic composition according to claim 1 or 2. Claim 6 (B) The content of the component is 0.01 to 1.5% by mass based on the total amount of the cosmetic composition, the cosmetic composition according to claim 1 or 2. Claim 7 (A) The mixing ratio of the component and (B) component is a mass ratio of (A):(B)=1:0.2 to 1:60, the cosmetic composition according to claim 1 or 2. Claim 8 (D) The content of the oil component is 0% by mass or more and 1% by mass or less based on the total amount of the cosmetic composition, the cosmetic composition according to claim 1 or 2. Claim 9 The cosmetic composition according to claim 1 or 2, which is an aqueous cosmetic composition.

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