Disposable cartridges for electrostatic applicator, systems, and methods thereof

Abstract

To provide an electrostatic applicator device equipped with a disposable cartridge for storing various solutions.SOLUTION: Provided is a disposable fluid delivery system for an electrostatic applicator 100. The system includes a nozzle housing with an air supply port 59, a voltage port, and a delivery outlet. A voltage wire has a contact in communication with a delivery tube in fluid communication with the delivery outlet. A syringe includes a barrel portion and a plunger configured to advance fluid from within the barrel portion through the delivery tube. A cartridge housing can at least partially enclose the nozzle housing, the voltage wire, and the syringe.SELECTED DRAWING: Figure 1A

Description

Technical Field

[0001] Cross - reference to related applications This application claims the priority and benefit of U.S. Provisional Patent Application No. 63 / 411,334, filed on September 29, 2022 and U.S. Non - Provisional Patent Application No. 18 / 110,854, filed on February 16, 2023, the contents of each of which are hereby incorporated by reference in their entirety as if fully set forth herein below

[0002] The solutions of the present disclosure relate to devices, systems, and methods for applying one or more pharmaceuticals (e.g., one or more biologic agents, polymer spun wound dressings, antiseptics, or anesthetics) to a treatment site (e.g., a wound surface of a subject). More specifically, the devices, systems, and methods are directed to an electrodynamic applicator device having a disposable cartridge for containing various solutions

Background Art

[0003] Infectious diseases frequently infect in places that should be safe, such as ambulances, hospitals, clinical sites, and other areas such as living support facilities. In fact, these healthcare - associated infections (HAIs) pose a major threat to patient safety and cause unnecessary economic burdens. For example, surgical site infections, which contribute significantly to HAIs, can not only cause pain and discomfort to patients, but may also lead to prolonged hospitalization and / or repeated hospitalizations There are numerous antibacterial and / or analgesic compounds available that are useful for patient treatment and infection avoidance. However, despite the availability of these compounds, current delivery methods are often lacking in effectiveness ​​​​​​​​

[0004] For example, oral and intravenous administrations are often insufficient to effectively control or treat severe pain in specific regions of the human body, and may lead to adverse events when high concentrations of doses are administered. To overcome some of the problems associated with oral and intravenous administrations, delivery vehicles such as hydrogels have been developed to provide spatial and temporal control over the release of various therapeutic agents, including small molecule drugs, peptides, and cells. However, hydrogels may also have certain undesirable characteristics, including being expensive and difficult to sterilize. More recently, electrospraying has emerged as a technology with potential biomedical applications. Electrospraying involves providing an electrostatic charge to a fluid as it is ejected from an electrostatic nebulizer. The electric field can break down the ejected liquid into small droplets, e.g., on the micron order, which can bind relatively uniformly to the treatment site with a small amount of solution. However, not all solutions, including disinfectants and / or analgesics, respond equally to the same electrostatic conditions, and differences in the viscosity and / or dielectric properties of the solution may require different optimal configurations for the electrostatic nebulizer device. Current electrostatic nebulizer devices do not provide a modular system that can accommodate different types of different solutions within a single electrostatic nebulizer device.

[0005]

[0006] The present disclosure solves these and other problems in the art. SUMMARY OF THE INVENTION

[0007] The subject matter of the present disclosure relates to a method for disposing the contents in a disposable cartridge (e.g., The electrostatic applicator delivers a therapeutic solution from a patient's treatment area.

[0008] In some examples, a disposable fluid delivery system for an electrostatic applicator is disclosed. The system includes a nozzle housing that includes an air supply port, a voltage port, and a delivery outlet. The voltage wire may include a contact that communicates with a delivery tube that is in fluid communication with the delivery outlet. the voltage wire is in electrical communication with the high voltage module and in the delivery tube. The syringe is configured to electrostatically charge the fluid contents. and a plunger configured to advance the fluid from within the portion through the delivery tube. The cartridge housing includes the nozzle housing, voltage wires, and serial The housing may at least partially surround the plunger.

[0009] In some examples, the voltage tube is in electrical communication with the voltage port and the voltage wire is It passes between a contact that communicates with the delivery tube and a contact port in the wall of the cartridge housing.

[0010] In some examples, the voltage tube and the voltage wire include a generally S-shape.

[0011] In some examples, the voltage tubes and voltage wires include a generally curved shape.

[0012] In some examples, the voltage tubes and voltage wires include straight shapes.

[0013] In some instances, the syringe contains a disinfectant, a sterilizing solution, an analgesic, an exosome, a biologic, , and / or liquid dressing solution.

[0014] In some examples, the analgesic agent includes one or more of lidocaine, levobupivacaine, acemetacin, ketorolac, and ceftazidime.

[0015] In some examples, the biologic agent includes one or more of stem cells and / or mammalian cells.

[0016] In some examples, the cartridge housing is a moldable plastic material.

[0017] In some examples, the cartridge housing includes a plurality of sections of moldable plastic that are connectable to create a single integral component.

[0018] In some examples, the voltage wire contact includes a wire loop that at least partially surrounds the outer surface of the delivery tube and provides a potential of about 1 V to about 40 kV.

[0019] In some examples, the voltage wire contact physically contacts the outer surface of the delivery tube and provides a potential of about 1 V to about 40 kV.

[0020] In some examples, when assembled with a syringe and nozzle housing, the delivery tube is configured to receive air from an air supply port, receive fluid from the barrel portion of the syringe, and discharge the fluid uniformly charged by a voltage wire.

[0021] In some examples, the disposable cartridge includes an air supply tube connected to an air supply port.

[0022] In some examples, the system is sized to receive a cartridge housing. A reusable electrostatic applicator including a cartridge chamber of a calling shape, and reuse The possible electrostatic applicator includes a high-voltage module configured to be in electrical communication with a voltage wire. The piston is disposed adjacent to the cartridge chamber and can be configured to advance a plunger enclosed within the cartridge housing when the cartridge housing is assembled with the cartridge chamber. When the cartridge housing is assembled with the cartridge chamber, it can be configured to advance a plunger enclosed within the cartridge housing. entered plunger.

[0023] In some examples, the reusable electrostatic applicator includes a motor configured to move a piston, one or more processors, and when executed by the one or more processors, cause the reusable electrostatic applicator to receive an activation signal, output a control signal to the motor to activate the piston, and output a control signal to a switch to supply a voltage from the high-voltage module to the voltage wire. a memory storing instructions to In some examples, the motor is a stepper motor, a linear actuator, a worm gear motor, and / or a planetary gear motor. In some examples, the motor is a drivable actuator system that uses motion transmission by an applied force.

[0024] In some examples, the reusable electrostatic applicator includes a display screen, and the activation signal is a user input to the display screen. In some examples, the reusable electrostatic applicator further includes an actuator, and the activation signal is a user input received by the actuator.

[0025] In some examples, the reusable electrostatic applicator includes a display screen, and the activation signal is a user input to the display screen. In some examples, the reusable electrostatic applicator further includes an actuator, and the activation signal is a user input received by the actuator.

[0026] In some examples, the reusable electrostatic applicator includes a display screen, and the activation signal is a user input to the display screen. In some examples, the reusable electrostatic applicator further includes an actuator, and the activation signal is a user input received by the actuator.

[0027] In some examples, the reusable electrostatic applicator further includes an actuator, and the activation signal is a user input received by the actuator. The activation signal is a user input received by the actuator.

[0028] In some examples, a reusable electrostatic applicator includes a housing base including a voltage source, a device housing including a cartridge chamber, and a handle extending between the housing base and the device housing. In some examples, the cartridge chamber is disposed within the device housing such that the actuator is disposed below the cartridge chamber relative to horizontal. In some examples, the reusable electrostatic applicator includes a wireless antenna, and the activation signal is a wireless signal received from a remote external user device.

[0029]

[0030]

[0031] In some examples, an electrostatic applicator system for delivering a treatment solution to a target site is disclosed. The system can include a handheld device housing, a motor within the device housing configured to drive a piston, a voltage source within the device housing, a high voltage module electrically connected to the voltage source, and a portable reusable electrostatic applicator including a cartridge chamber. A disposable cartridge is removably insertable into the cartridge chamber and the disposable cartridge includes a nozzle housing including an air supply port, a voltage port, and a delivery outlet. The voltage wire is provided with a contact communicating with a delivery tube in fluid communication with the delivery outlet. The syringe is provided with a barrel portion and a plunger configured to advance fluid distally through the delivery tube from within the barrel portion. A cartridge housing at least partially surrounding the nozzle housing, the voltage wire, and the syringe is included.​​​​​​​​​​​​​​

[0032] In some examples, the voltage wire and the voltage tube include a voltage wire that includes a linear and / or curved or substantially S-shaped configuration within the cartridge housing. In some examples, the cartridge housing is a formable plastic material.

[0033] In some examples, the cartridge housing includes a plurality of connected sections of formable plastic.

[0034] In some examples, the cartridge chamber includes a wall that includes a high voltage contact that is in electrical communication with a high voltage module and an air supply port that is in fluid communication with a pump disposed within the device housing. The voltage wire can be in electrical communication with the high voltage contact of the wall. The contact of the voltage wire can physically contact the outer surface of the delivery tube to provide a potential of about 1 V to about 40 kV. In some examples, the HV module includes a plurality of rotating diodes such that the HV module is configured to generate both a positive high voltage and a negative high voltage depending on the orientation of the rotating diodes.

[0035] In some examples, the HV module includes a circuit board that includes a first positive high voltage multiplier system and a second negative high voltage multiplier system. In some examples, the delivery tube is configured to receive air from the air supply port, receive fluid from the barrel portion of the syringe, and discharge the fluid uniformly charged by the voltage wire when assembled with the syringe and the nozzle housing. In some examples, the HV module includes a plurality of rotating diodes such that the HV module is configured to generate both a positive high voltage and a negative high voltage depending on the orientation of the rotating diodes. In some examples, the HV module includes a circuit board that includes a first positive high voltage multiplier system and a second negative high voltage multiplier system. In some examples, the delivery tube is configured to receive air from the air supply port, receive fluid from the barrel portion of the syringe, and discharge the fluid uniformly charged by the voltage wire when assembled with the syringe and the nozzle housing.

[0036] In some examples, the HV module includes a plurality of rotating diodes such that the HV module is configured to generate both a positive high voltage and a negative high voltage depending on the orientation of the rotating diodes. In some examples, the HV module includes a plurality of rotating diodes such that the HV module is configured to generate both a positive high voltage and a negative high voltage depending on the orientation of the rotating diodes. In some examples, the HV module includes a plurality of rotating diodes such that the HV module is configured to generate both a positive high voltage and a negative high voltage depending on the orientation of the rotating diodes.

[0037] In some examples, the HV module includes a circuit board that includes a first positive high voltage multiplier system and a second negative high voltage multiplier system. In some examples, the HV module includes a circuit board that includes a first positive high voltage multiplier system and a second negative high voltage multiplier system.

[0038] In some examples, the delivery tube is configured to receive air from the air supply port, receive fluid from the barrel portion of the syringe, and discharge the fluid uniformly charged by the voltage wire when assembled with the syringe and the nozzle housing. In some examples, the delivery tube is configured to receive air from the air supply port, receive fluid from the barrel portion of the syringe, and discharge the fluid uniformly charged by the voltage wire when assembled with the syringe and the nozzle housing. In some examples, the delivery tube is configured to receive air from the air supply port, receive fluid from the barrel portion of the syringe, and discharge the fluid uniformly charged by the voltage wire when assembled with the syringe and the nozzle housing.

[0039] In some examples, the device housing includes a handle and the voltage source is connected to the device housing. The handle is located within the housing base of the device and is connected to the device housing and the housing base. It is placed between.

[0040] In some examples, the reusable electrostatic applicator includes one or more processors. and, when executed by one or more processors, produces a reusable electrostatic application. (a) the high voltage module via a voltage wire to the delivery tube; (b) the position of the piston and plunger of the disposable cartridge; and / or or (c) air flow from the device housing to the air supply port via an air supply tube. A memory for storing instructions for outputting a control signal to a motor that controls a pump that adjusts the include.

[0041] In some instances, the disposable cartridge comprises a syringe and / or a disposable cartridge. The data includes information about the operating parameters of the contents stored in the separate fluid reservoirs of the ridge. The reusable electrostatic applicator includes one or more processors, each processor including an on-chip memory including and communicating with the on-board memory to obtain information regarding the contents of the disposable cartridge. The nozzle is configured to control at least one of the amount, the potential, and the nozzle setting.

[0042] In some instances, the disposable cartridge comprises a syringe and / or a disposable cartridge. The data includes information about the operating parameters of the contents stored in the separate fluid reservoirs of the ridge. The reusable electrostatic applicator includes one or more processors, each processor including a processor and a processor for storing the reusable electrostatic applicator. , communicate with the built-in memory to obtain information about the contents of the disposable cartridge, and is configured to control the motor speed, air intake, and / or applied voltage.

[0043] In some examples, the memory is incorporated into the processor of the electrostatic applicator system and includes operating instructions for operating the electrostatic applicator system.

[0044] In some examples, a near field communication (NFC) tag includes the memory.

[0045] In some examples, the instructions further include reading NFC information regarding the operating parameters of the disposable cartridge and displaying at least a portion of the NFC-read information (e.g., information such as identification information of the contents, capacity, etc.) on a display screen. In some aspects the information can be written to the NFC by the processor of the electrostatic applicator system.

[0046] In some examples, the applicator includes a display screen, and the activation signal is a user input to the display screen.

[0047] In some examples, the applicator includes an actuator, and the activation signal is a user input received by the actuator.

[0048] In some examples, the applicator includes a communication system within the applicator's CPU. The communication system can include a wireless antenna (e.g., one or more transceivers can be compatible with a short-range wireless communication connection), and the activation signal is a wireless signal received from an external user device.

[0049] ​​​​​ In some examples, the applicator includes an accelerometer configured to output a motion signal to one or more processors in response to detecting movement of the electrostatic applicator system

[0050] In some examples, the applicator includes a display screen on the electrostatic applicator system that is activated by a wake signal from one or more processors in response to the one or more processors receiving a motion signal and the activation signal is a user input to the display screen

[0051] In some examples, the electrostatic applicator system further includes a proximity sensor configured to detect a distance between the system and an intended target. One of the control signals is output to the motor in response to the distance being within a predetermined distance threshold. In some examples, the predetermined distance threshold can be from about 2 inches to about 18 inches, but most preferably from about 4 inches to about 6 inches. One of the control signals is output to a switch to control the voltage of the electrostatic applicator system in response to the distance being within a predetermined distance threshold

[0052] In some examples, the electrostatic applicator system further includes a proximity sensor configured to detect a distance between the system and an intended target, and one of the control signals is output to prevent operation of the motor in response to the distance being greater than or less than a predetermined distance threshold

[0053] In some examples, the electrostatic applicator system further includes a proximity sensor configured to detect a distance between the system and an intended target, and one of the control signals is output to a switch to control the voltage of the electrostatic applicator system in response to the distance being within a predetermined distance threshold ​​​​​​​​​​​​​ Output to a switch to prevent delivery of voltage of an electrostatic applicator system in response to being greater than or less than a predetermined distance threshold.

[0054] In some examples, methods for operating an electrostatic applicator system are disclosed. The method includes contacting a voltage contact at a first end of a voltage wire in a first disposable cartridge with a voltage contact of the electrostatic applicator system, fluidly connecting a first end of an air supply port in the first disposable cartridge with an air supply port of the electrostatic applicator system, and inserting the first disposable cartridge into a chamber housing of the electrostatic applicator system such that a plunger of a syringe containing a first fluid in the first disposable cartridge aligns with a piston of the electrostatic applicator system. The method can include operating a motor and delivering a potential to a delivery tube of the first disposable cartridge in response to an activation input to the electrostatic applicator system.

[0055] In some examples, operating the motor and delivering the potential causes the first fluid to be advanced from the syringe through the delivery tube and sprayed onto a target site in a predetermined spray pattern as electrostatically charged atomized fluid droplets. In some aspects, the target site may be oppositely charged relative to the droplets. In some aspects, the maximum potential path may be between the target site and the charged droplets, although the target site need not be oppositely charged in particular.

[0056] In some examples, operating the motor and delivering the potential causes the first fluid to be advanced from the syringe through the delivery tube and sprayed onto a target site in a predetermined spray pattern as electrostatically charged atomized fluid droplets. ​​​​​​​​​​​​Advance the fluid through a delivery tube from a syringe and convey it in a predetermined spray pattern. Spray it as electrostatically charged atomized fluid droplets onto a target site oppositely charged.

[0057] In some examples, the method includes removing a first disposable cartridge from the chamber housing and inserting a second disposable cartridge into the chamber housing, where the second disposable cartridge contains a second fluid.

[0058] In some examples, the second disposable cartridge is configured for electrospinning. The method includes operating a motor by a second activation input to the electrostatic applicator system and delivering a potential to the delivery tube of the second disposable cartridge such that the second fluid in the syringe of the second disposable cartridge is delivered from the second fluid to the target site (e.g., at a predetermined speed and / or emission pattern) by the delivery tube of the second disposable cartridge. In some examples, the second fluid can suspend fibers therein before the electrospun fibers are formed.

[0059] In some examples, the first disposable cartridge and the second disposable cartridge each include a built-in memory containing information about the respective operating parameters of the first fluid and the second fluid. When either the first disposable cartridge or the second disposable cartridge is inserted into the chamber housing, the operating parameters are transmitted to the memory of the electrostatic applicator system, and the operating parameters include the speed of the motor, the air intake, and the voltage applied to the delivery tube of each disposable cartridge. ​​​​​​​​​​​​​

[0060] In some examples, when one of a first disposable cartridge or a second disposable cartridge is inserted into the chamber housing, the registry associated with the information of the operating parameters of the first disposable cartridge or the second disposable cartridge is tagged as a used cartridge, and when it is determined that the first disposable cartridge or the second disposable cartridge is a used cartridge, the motor is activated and / or the potential is prevented from being delivered to the delivery tube of the first disposable cartridge or the second disposable cartridge. In some examples, when one of a first disposable cartridge or a second disposable cartridge is inserted into the chamber housing, the registry associated with the information of the operating parameters of the first disposable cartridge or the second disposable cartridge is tagged as a used cartridge, and when it is determined that the first disposable cartridge or the second disposable cartridge is a used cartridge, the motor is activated and / or the potential is prevented from being delivered to the delivery tube of the first disposable cartridge or the second disposable cartridge. In some examples, when one of a first disposable cartridge or a second disposable cartridge is inserted into the chamber housing, the registry associated with the information of the operating parameters of the first disposable cartridge or the second disposable cartridge is tagged as a used cartridge, and when it is determined that the first disposable cartridge or the second disposable cartridge is a used cartridge, the motor is activated and / or the potential is prevented from being delivered to the delivery tube of the first disposable cartridge or the second disposable cartridge. In some examples, when one of a first disposable cartridge or a second disposable cartridge is inserted into the chamber housing, the registry associated with the information of the operating parameters of the first disposable cartridge or the second disposable cartridge is tagged as a used cartridge, and when it is determined that the first disposable cartridge or the second disposable cartridge is a used cartridge, the motor is activated and / or the potential is prevented from being delivered to the delivery tube of the first disposable cartridge or the second disposable cartridge. In some examples, when one of a first disposable cartridge or a second disposable cartridge is inserted into the chamber housing, the registry associated with the information of the operating parameters of the first disposable cartridge or the second disposable cartridge is tagged as a used cartridge, and when it is determined that the first disposable cartridge or the second disposable cartridge is a used cartridge, the motor is activated and / or the potential is prevented from being delivered to the delivery tube of the first disposable cartridge or the second disposable cartridge. In some examples, when one of a first disposable cartridge or a second disposable cartridge is inserted into the chamber housing, the registry associated with the information of the operating parameters of the first disposable cartridge or the second disposable cartridge is tagged as a used cartridge, and when it is determined that the first disposable cartridge or the second disposable cartridge is a used cartridge, the motor is activated and / or the potential is prevented from being delivered to the delivery tube of the first disposable cartridge or the second disposable cartridge. In some examples, when one of a first disposable cartridge or a second disposable cartridge is inserted into the chamber housing, the registry associated with the information of the operating parameters of the first disposable cartridge or the second disposable cartridge is tagged as a used cartridge, and when it is determined that the first disposable cartridge or the second disposable cartridge is a used cartridge, the motor is activated and / or the potential is prevented from being delivered to the delivery tube of the first disposable cartridge or the second disposable cartridge.

[0061] In some examples, the first disposable cartridge and the second disposable cartridge contain different fluids. In some examples, the first disposable cartridge and the second disposable cartridge contain different fluids.

[0062] In some examples, the first disposable cartridge and the second disposable cartridge each include at least one of different voltage wires and different delivery tubes according to their respective nozzle housings, the first fluid stored in each disposable cartridge, and / or the second fluid. In some examples, the first disposable cartridge and the second disposable cartridge each include at least one of different voltage wires and different delivery tubes according to their respective nozzle housings, the first fluid stored in each disposable cartridge, and / or the second fluid. In some examples, the first disposable cartridge and the second disposable cartridge each include at least one of different voltage wires and different delivery tubes according to their respective nozzle housings, the first fluid stored in each disposable cartridge, and / or the second fluid. In some examples, the first disposable cartridge and the second disposable cartridge each include at least one of different voltage wires and different delivery tubes according to their respective nozzle housings, the first fluid stored in each disposable cartridge, and / or the second fluid.

[0063] In some examples, providing an activation input includes inputting information about the first fluid into the display screen of the electrostatic applicator system and providing an input to the display screen. In some examples, providing an activation input includes inputting information about the first fluid into the display screen of the electrostatic applicator system and providing an input to the display screen. In some examples, providing an activation input includes inputting information about the first fluid into the display screen of the electrostatic applicator system and providing an input to the display screen.

[0064] In some examples, the method includes pairing the electrostatic applicator system with an external user device via a short-range wireless connection, and providing an activation input includes In some examples, the method includes pairing the electrostatic applicator system with an external user device via a short-range wireless connection, and providing an activation input includes Inputting information about the fluid of 1 into an external user device and providing the input to the display screen of the external user device. Including.

[0065] In some examples, a method implemented by a computer for operating an electrostatic applicator system is disclosed. The method includes activating a motor by a startup input to the electrostatic applicator system and / or delivering a potential to a delivery tube of a disposable cartridge removably attached to a chamber housing of the electrostatic applicator system via a voltage wire of the disposable cartridge, advancing a fluid content from a syringe through the delivery tube into the disposable cartridge by the motor biasing a plunger of the syringe, electrostatically charging the fluid content in the delivery tube by the voltage wire, and discharging the electrostatically charged fluid content from a nozzle assembly of the disposable cartridge to a treatment site. By a startup input to the electrostatic applicator system. Operating the motor and / or delivering a potential to the delivery tube of the disposable cartridge. From a high-voltage module of the electrostatic applicator system to the delivery tube of the disposable cartridge. Removably attached to the chamber housing of the electrostatic applicator system. Advancing the fluid content from the syringe through the delivery tube into the disposable cartridge by the motor biasing the plunger of the syringe. Electrostatically charging the fluid content in the delivery tube by the voltage wire. And discharging the electrostatically charged fluid content from the nozzle assembly of the disposable cartridge to the treatment site. Including electrostatically charging the fluid content in the barrel portion of the syringe proximal to the delivery tube by the voltage wire. In some examples, the method can include electrostatically charging the fluid content in the barrel portion of the syringe proximal to the delivery tube by the voltage wire.

[0066] In some examples, the step of discharging the electrostatically charged fluid content from the nozzle assembly includes controlling the intake of air from an air supply of the electrostatic applicator system into the disposable cartridge so that the electrostatically charged fluid content is atomized into droplets in a predetermined spray pattern onto the target site. Including electrostatically charging the fluid content in the barrel portion of the syringe proximal to the delivery tube by the voltage wire.

[0067] In some examples, the step of discharging the electrostatically charged fluid content from the nozzle assembly includes controlling the intake of air from an air supply of the electrostatic applicator system into the disposable cartridge so that the electrostatically charged fluid content is atomized into droplets in a predetermined spray pattern onto the target site. Including electrostatically charging the fluid content in the barrel portion of the syringe proximal to the delivery tube by the voltage wire. In some examples, the step of discharging the electrostatically charged fluid content from the nozzle assembly includes controlling the intake of air from an air supply of the electrostatic applicator system into the disposable cartridge so that the electrostatically charged fluid content is atomized into droplets in a predetermined spray pattern onto the target site. Including controlling the intake of air from an air supply of the electrostatic applicator system into the disposable cartridge so that the electrostatically charged fluid content is atomized into droplets in a predetermined spray pattern onto the target site.

[0068] In some examples, the step of discharging the electrostatically charged fluid contents from the nozzle assembly includes being delivered as electrospun fibers from the electrostatically charged fluid contents .

[0069] In some examples, the method includes detecting, by a proximity sensor, the distance between the electrostatic applicator system and a target intended to be acted upon, and in response to the distance being within a predetermined distance threshold, activating an input to operate a motor and / or deliver a potential to a high-voltage module .

[0070] In some examples, the method includes detecting, by a proximity sensor, the distance between the electrostatic applicator system and a target intended to be acted upon, and in response to the distance being greater than or less than a predetermined distance threshold, preventing operation of the motor and / or preventing the high-voltage module from delivering a potential .

[0071] In some examples, the method includes, in response to one or more processors receiving a motion signal, activating, by a display screen on the electrostatic applicator system, a wake signal from one or more processors of the electrostatic applicator system, and activating an input to operate a motor and / or deliver a potential to a high-voltage module in response to the wake signal .

[0072] In some examples, the disposable cartridge includes a built-in memory containing information regarding the operating parameters of the fluid contents stored within the syringe . In this regard, the method includes, by one or more processors of a reusable electrostatic applicator, the disposable cartridge ​​​​​​​To obtain information regarding the fluid contents of the cartridge, communicate with the built-in memory and discard one or more operating parameters of the cartridge so as to control at least one of flow rate, potential, and nozzle settings, wherein the one or more operating parameters can include motor speed, air intake, and / or applied voltage of the disposable cartridge.

[0073] In some examples, the memory is incorporated into a processor of an electrostatic applicator system and includes operating instructions of a method executed by a computer for operating the electrostatic applicator system.

[0074] In some examples, a system for operating an electrostatic applicator system is disclosed. The system can include at least one memory storing instructions and at least one processor configured to execute the instructions to perform operations. In some embodiments, the operations are actuating a motor by a start input to the electrostatic applicator system and / or delivering a potential from a high voltage module of the electrostatic applicator system through a voltage wire to a delivery tube of a disposable cartridge removably attached to a chamber housing of the electrostatic applicator system, advancing fluid contents from a syringe through the delivery tube and into the disposable cartridge by the motor urging a plunger of the syringe, electrostatically charging the fluid contents within the delivery tube by the voltage wire, and discharging the electrostatically charged fluid contents from a nozzle assembly of the disposable cartridge to a treatment site. ​​can include the following.

[0075] In some examples, the step of discharging the electrostatically charged fluid content from the nozzle assembly includes atomizing the electrostatically charged fluid content into droplets in a predetermined spray pattern onto a reversely charged target site by controlling the intake of air from an air pump in the disposable cartridge into the trigger.

[0076] In some examples, the step of discharging the electrostatically charged fluid content from the nozzle assembly includes delivering it as electrospun fibers onto a target site having a potential difference at a predetermined speed and / or pattern from the electrostatically charged fluid content.

[0077] In some examples, the operation includes detecting, by a proximity sensor, the distance between the electrostatic applicator system and a target intended for it, and in response to the distance being within a predetermined distance threshold, activating the motor and / or sending an activation input to deliver a potential to a high voltage module.

[0078] In some examples, the operation includes, in response to one or more processors receiving a motion signal, activating, by a display screen on the electrostatic applicator system, a wake signal from one or more processors of the electrostatic applicator system, and in response to the wake signal, activating the motor and / or sending an activation input to deliver a potential to a high voltage module.

[0079] In some examples, the disposable cartridge stores the fluid content in a syringe It includes a built-in memory containing information about the operating parameters. In this regard, the operation is reusable by one or more processors of the electrostatic applicator to communicate with the built-in memory to obtain information about the fluid contents of the disposable cartridge and to control one or more operating parameters of the disposable cartridge, by controlling at least one of flow rate, potential, and nozzle settings, wherein the one or more operating parameters can include motor speed, air intake, and / or the applied voltage of the disposable cartridge.

[0080] In some examples, the memory is incorporated into the processor of the electrostatic applicator system and includes operating instructions of a method executed by a computer for operating the electrostatic applicator system.

[0081] In some examples, a non-transitory computer-readable medium storing instructions that, when executed by a processor, cause the processor to execute a method for operating an electrostatic applicator system is disclosed. The method includes activating a motor by a startup input to the electrostatic applicator system and / or delivering a potential from a high-voltage module of the electrostatic applicator system to a delivery tube of a disposable cartridge removably attached to the chamber housing of the electrostatic applicator system via a voltage wire of the disposable cartridge, advancing the fluid contents of the syringe through the delivery tube into the disposable cartridge by the motor biasing the plunger of the syringe, and electrostatically charging the fluid contents within the delivery tube by the voltage wire. ​​​​​​​​​​​​​​Releasing the electrostatically charged fluid contents from the nozzle assembly of a disposable cartridge to a treatment site can include.

[0082] In some examples, the step of releasing the electrostatically charged fluid contents from the nozzle assembly includes controlling the intake of air from the air supply of an electrostatic applicator system into the disposable cartridge such that the electrostatically charged fluid contents are atomized into droplets in a predetermined spray pattern onto the oppositely charged target site. In some examples, the predetermined spray pattern can include droplets that are similarly charged and repelled from other droplets as they are drawn towards the oppositely charged target site. In some examples, the droplets can be positively charged and the target site can be negatively charged. In some examples, the droplets can be negatively charged and the target site can be positively charged.

[0083] In some examples, the step of releasing the electrostatically charged fluid contents from the nozzle assembly includes delivering the electrostatically charged fluid contents as electrospun fibers onto the oppositely charged target site at a predetermined velocity and / or pattern.

[0084] In some examples, the method includes detecting, by a proximity sensor, the distance between the electrostatic applicator system and the intended target, and in response to the distance being within a predetermined distance threshold, sending an activation input to operate a motor and / or deliver a potential to a high voltage module.

[0085] In some examples, the method includes one or more processors receiving a movement signal In response, activating a wake signal from one or more processors of the electrostatic applicator system by a display screen on the electrostatic applicator system, and in response to the wake signal, sending an activation input to operate the motor and / or deliver a potential to a high voltage module. In some examples, the disposable cartridge includes a built-in memory containing information about one or more operating parameters of the fluid contents stored within the syringe. The method includes communicating with the built-in memory to obtain information about the fluid contents of the disposable cartridge by one or more processors of a reusable electrostatic applicator, and controlling at least one of flow rate, potential, and nozzle settings to control one or more operating parameters of the disposable cartridge, where the one or more operating parameters can include motor speed, air intake, and / or applied voltage of the disposable cartridge. To achieve the foregoing and related purposes, certain exemplary aspects are described herein in connection with the following description and the accompanying drawings. However, these aspects merely illustrate some of the various ways in which the principles of the claimed subject matter can be used, and the claimed subject matter is intended to include all such aspects and their equivalents. Other advantages and novel features will become apparent from the following detailed description when considered in conjunction with the drawings. The above and further aspects of the present invention will be further apparent with reference to the following description in conjunction with the accompanying drawings.

[0086] In some examples, the disposable cartridge includes a built-in memory containing information about one or more operating parameters of the fluid contents stored within the syringe. The method includes communicating with the built-in memory to obtain information about the fluid contents of the disposable cartridge by one or more processors of a reusable electrostatic applicator, and controlling at least one of flow rate, potential, and nozzle settings to control one or more operating parameters of the disposable cartridge, where the one or more operating parameters can include motor speed, air intake, and / or applied voltage of the disposable cartridge. To achieve the foregoing and related purposes, certain exemplary aspects are described herein in connection with the following description and the accompanying drawings. However, these aspects merely illustrate some of the various ways in which the principles of the claimed subject matter can be used, and the claimed subject matter is intended to include all such aspects and their equivalents. Other advantages and novel features will become apparent from the following detailed description when considered in conjunction with the drawings. The above and further aspects of the present invention will be further apparent with reference to the following description in conjunction with the accompanying drawings. In response, activating a wake signal from one or more processors of the electrostatic applicator system by a display screen on the electrostatic applicator system, and in response to the wake signal, sending an activation input to operate the motor and / or deliver a potential to a high voltage module. In some examples, the disposable cartridge includes a built-in memory containing information about one or more operating parameters of the fluid contents stored within the syringe. The method includes communicating with the built-in memory to obtain information about the fluid contents of the disposable cartridge by one or more processors of a reusable electrostatic applicator, and controlling at least one of flow rate, potential, and nozzle settings to control one or more operating parameters of the disposable cartridge, where the one or more operating parameters can include motor speed, air intake, and / or applied voltage of the disposable cartridge.

[0087] To achieve the foregoing and related purposes, certain exemplary aspects are described herein in connection with the following description and the accompanying drawings. However, these aspects merely illustrate some of the various ways in which the principles of the claimed subject matter can be used, and the claimed subject matter is intended to include all such aspects and their equivalents. Other advantages and novel features will become apparent from the following detailed description when considered in conjunction with the drawings. The above and further aspects of the present invention will be further apparent with reference to the following description in conjunction with the accompanying drawings. In response, activating a wake signal from one or more processors of the electrostatic applicator system by a display screen on the electrostatic applicator system, and in response to the wake signal, sending an activation input to operate the motor and / or deliver a potential to a high voltage module. In some examples, the disposable cartridge includes a built-in memory containing information about one or more operating parameters of the fluid contents stored within the syringe. The method includes communicating with the built-in memory to obtain information about the fluid contents of the disposable cartridge by one or more processors of a reusable electrostatic applicator, and controlling at least one of flow rate, potential, and nozzle settings to control one or more operating parameters of the disposable cartridge, where the one or more operating parameters can include motor speed, air intake, and / or applied voltage of the disposable cartridge.

[0088] The above and further aspects of the present invention will be further apparent with reference to the following description in conjunction with the accompanying drawings. is described, and in the various figures, like reference numerals indicate like structural elements and features. The drawings are not necessarily to scale and instead emphasis is placed on showing the principles of the present invention. The figures show one or more implementations of the device of the present invention by way of example only and not by way of limitation. BRIEF DESCRIPTION OF THE DRAWINGS

[0089]

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[0090] Although exemplary embodiments of the disclosed technology are described in detail herein, it is to be understood that other embodiments are contemplated. Accordingly, it is not intended to limit the scope of the disclosed technology to the details of construction and arrangement of components described in the following description or illustrated in the drawings. The disclosed technology is capable of other embodiments and of being practiced or carried out in various ways.

[0091] As used in this specification and the appended claims, the singular forms "a", "an" and "the" include plural referents unless the context clearly indicates otherwise. It should also be noted that "comprising", "containing", or "including" means that at least the specified compound, element, particle or method step is present in a composition or article or method, but does not exclude the presence of other compounds, materials, particles, method steps, even if these other compounds, materials, particles, method steps have the same function as those specified.

[0092] In this disclosure, relative terms such as "about", "substantially", or "approximately" are used to indicate a possible variation of ±10% from the recited value.

[0093] Terms are used for clarity when describing exemplary embodiments. Each term is intended in its broadest sense as understood by one of ordinary skill in the art and is intended to include all technical equivalents that operate in a similar manner to achieve a similar purpose. Reference to one or more steps of a method does not preclude the presence of additional method steps or intervening method steps between those explicitly identified. Method steps may be performed in an order different from that described herein without departing from the scope of the or a reference to a plurality of components does not exclude the presence of additional components or intervening components between those components that are explicitly identified It should also be understood that is desired.

[0094] As discussed herein, the treatment site of a "subject" or "patient" can be a wound site or treatment of a human or any animal. The animal can be any of a variety of suitable types including, but not limited to, mammals, veterinary animals, livestock animals or pet-type animals It should be understood that. For example, the animal can be a laboratory animal (e.g., rat, dog, pig, monkey, etc.) specifically selected to have certain characteristics similar to humans. It should be understood that the subject can be, for example, any applicable human patient. As discussed herein, an "operator" can include, but is not limited to, a physician, surgeon, nurse, physical therapist, or other healthcare professional, or any other appropriate individual, or a delivery device associated with the application of a treatment solution to the treatment site of a subject. It should be understood that, for example, it can be any applicable human patient.

[0095] As discussed herein, a "treatment solution" can be one or more fluids (e.g., liquid and / or emulsion solution, gel, and / or mixture), and can include one or more of a disinfectant solution, a bactericidal solution, an analgesic, exosomes, a biologic, chlorhexidine gluconate, povidone iodine,

[0096] and / or a liquid bandage solution. The analgesic can include one or more of lidocaine, levobupivacaine, acemetacin, ketorolac and ceftazidime. The biologic can include stem cells and / or mammalian primary cells and / or one or more of It can include. The analgesic can include one or more of lidocaine, levobupivacaine, acemetacin, ketorolac and ceftazidime. The biologic can include stem cells and / or mammalian primary cells one or more of , one or more of pharmaceuticals, gels (e.g., hydrogels), reconfigurable forms (e.g., immiscible components and / or lyophilized components that are mixable with one or more solvents) can be included. The bactericidal agent can be one or more alcohols, aldehydes, oxidizing agents, phenols, antibacterial agents such as quaternary ammonium compounds, biguanides, analgesics, surfactants, and / or wound cleansing components, or can be delivered (e.g., applied, sprayed, and / or atomized by an electrostatic applicator) to the treatment site of a patient and can contain any other contents and / or pharmaceuticals that can be conceivably stored within the cartridge of the present disclosure. The treatment solution can contain any concentration or mixture of the components disclosed herein. The term "treatment solution" can also include one or more tracking materials (e.g., gels having a trackable form mixed with the treatment solution). The treatment solution can contain any number of small molecule drugs, peptides, cells, and other therapeutic agents. In some embodiments, the treatment solution can contain one or more active pharmaceutical ingredients, growth factors, nutritional factors, exosomes, mammalian regenerative cells, and / or a support matrix. In some embodiments, the treatment solution can contain lidocaine, levobupivacaine, acemetacin, ketorolac, etc., or any combination thereof. The terms "distal" or "proximal" are used in the following description with respect to the position or direction relative to a reference point (e.g., a user such as a treating physician or a medical interventionist). "Distal"

[0097] or "distally" refers to a position that is away from or in the direction away from the reference point. " Proximal" or "proximally" refers to a position that is closer to or in the direction closer to the reference point. The treatment solution can contain any concentration or mixture of the components disclosed herein. In some embodiments, the treatment solution can contain one or more active pharmaceutical ingredients, growth factors, nutritional factors, exosomes, mammalian regenerative cells, and / or a support matrix. In some embodiments, the treatment solution can contain lidocaine, levobupivacaine, acemetacin, ketorolac, etc., or any combination thereof. The terms "distal" or "proximal" are used in the following description with respect to the position or direction relative to a reference point (e.g., a user such as a treating physician or a medical interventionist). "Distal"

[0098] or "distally" refers to a position that is away from or in the direction away from the reference point. "Proximal" or "proximally" refers to a position that is closer to or in the direction closer to the reference point. "Distal" or "distally" refers to a position that is away from or in the direction away from the reference point. " "Proximal" or "proximally" or "adjacent" refers to a position near or in the direction toward a reference point. It is a position.

[0099] Increasingly more attention and resources are being focused on the development of effective treatment methods for pain and infectious diseases. The most common methods of treating pain and infectious diseases include oral administration and intravenous (IV) administration of drugs. Although these methods are widespread, they often lack the effectiveness of drug delivery methods. For example, when a drug is administered via an oral administration method or an IV administration method, its therapeutic effect becomes systemic rather than local, that is, the drug targets the entire patient rather than the local treatment site. To overcome some of these problems, delivery vehicles such as more specific local therapies, such as hydrogel compounds, have been developed to provide spatial and temporal control over the release of various therapeutic agents including small molecule drugs, peptides, and cells. However, these treatments may also have drawbacks. The synthetic carriers of these therapeutic agents are often costly, and since they are fragile polymer chains, it can be difficult to sterilize the polymer chains in the solution / hydrogel combination. More recently, the concept of electrospraying a treatment solution containing an antibacterial solution and / or an analgesic solution onto the treatment site has been explored. Electrospraying is a technique that exposes a treatment solution to an electric field to charge the fluid. The electric field provided by a voltage source can generate a charge (e.g., a positive charge or a negative charge) in the administered fluid. This is particularly useful in the biomedical field because the natural resting state of human cells is a negative state (i.e., a state of negative charge). This imbalance is due to potassium and sodium inside and outside the cells that form the capacitance in the patient's body. These methods are widespread, but often lack the effectiveness of drug delivery methods. For example, when a drug is administered via an oral administration method or an IV administration method, its therapeutic effect becomes systemic rather than local, that is, the drug targets the entire patient rather than the local treatment site. To overcome some of these problems, more specific local therapies, such as hydrogel compounds, have been developed to provide spatial and temporal control over the release of various therapeutic agents including small molecule drugs, peptides, and cells. However, these treatments may also have drawbacks. The synthetic carriers of these therapeutic agents are often costly, and since they are fragile polymer chains, it can be difficult to sterilize the polymer chains in the solution / hydrogel combination.

[0100] More recently, the concept of electrospraying a treatment solution containing an antibacterial solution and / or an analgesic solution onto the treatment site has been explored. Electrospraying is a technique that exposes a treatment solution to an electric field to charge the fluid. The electric field provided by a voltage source can generate a charge (e.g., a positive charge or a negative charge) in the administered fluid. This is particularly useful in the biomedical field because the natural resting state of human cells is a negative state (i.e., a state of negative charge). This imbalance is due to potassium and sodium inside and outside the cells that form the capacitance in the patient's body. is created by ions of mu. This polarity difference creates a natural attraction between the treatment site and the solution being sprayed.

[0101] However, negative / positive attraction is not the only advantage of electrostatic spraying. For example, by exposing the fluid to this electric field, small droplets (e.g., micron size) can be generated to provide a relatively uniformly dispersed layer of the treatment solution. When the electrical stress due to the charge accumulates on the droplet exceeding its surface tension, the droplet collapses and / or atomizes into very fine droplets, which is known as Rayleigh breakup or Coulomb fission. As discussed herein, the term "atomize" is understood as part or all of the process of substantially converting a liquid solution into very fine particles

[0102] or droplets. The dielectric constant or conductivity of the solvent can play an important role in determining the morphology of the microparticles. Other factors that affect the way the liquid atomizes include vapor pressure, viscosity and miscibility of the treatment solution, voltage applied to the solution, etc. It should be noted that prior designs of electrospray devices did not consider these various types of parameters. This is For use. Further, each disposable cartridge can be individually adjusted and / or communicates with a reusable electrostatic applicator to individually adjust the parameters necessary to administer the preferred particles (e.g., from nano-particles to micro-particles) droplets for the treatment of the target. It can be done.

[0103] Referring to the drawings, FIG. 1A provides an exemplary applicator 100 placed in an exploded state with an exemplary base 80. According to the present disclosure, the applicator 100 can be used in combination with a disposable cartridge 50. The applicator 100 can include an applicator housing 10 that can include an upper portion 31, a lower base portion 30 at the bottom, and a handle portion 15 between the portion 30 and the portion 31. Further, a front cartridge support portion 32 can be disposed between the portion 30 and the portion 32. In some embodiments, an obtuse angle can be formed between the outer surface aspects of the portion 30 and the portion 32, and the handle portion 15 can be orthogonal to the portion 30 and / or the portion 31. Also, although shown as a handheld pistol-shaped device, the reusable applicator 100 need not have a pistol-shaped design. This is because the components herein can also be combined with other electrosprayer designs, such as, but not limited to, a completely cylindrical handheld electrosprayer design. design. Because the components herein can also be combined with other electrosprayer designs, such as, but not limited to, a completely cylindrical handheld electrosprayer design. For example, but not limited to, a completely cylindrical handheld electrosprayer design.

[0104] As clearly shown in FIG. 3, the portion 30 provides a potential for generating an electric field in the nozzle assembly 60 of the cartridge 50 and / or houses a battery B that can supply power to the components of the applicator 100 (e.g., the CPU and / or the HV module 86). (e.g., the CPU and / or the HV module 86). ​​​​​Battery B may be one or more DC batteries, such as lithium-ion batteries. Battery B may include, but is not limited to, about 1 V to about 40 kV. In some examples, a voltage sufficient to generate the above-mentioned potentials can be provided. In some examples, the voltage supply of battery B may range from about 1 V to 8 kV. or multiple rechargeable batteries. In this example, the applicator 100, such as portion 32, The embodiment is to turn on the voltage supply of battery B (e.g., by inducting) when the device is not in use. The portion 30 can be engaged with a charging base 80 that can be charged (inductively or electrically). The device is configured to be removed from the charging base 80 by pressing a release portion (not shown). In some examples, the applicator 100 may be Including an actuator, e.g., a button 35, that can activate and / or actuate the component For example, the button 35 can be equipped with a battery, which may include a rechargeable modular battery, such as a DC battery. Power supply from battery B (see Figure 3) can be started. By starting the system, the system can be charged directly, inductively, indirectly, or in any combination of these. Power is provided to electrostatically charge the liquid solution in the cartridge via any combination of In the case of direct charging, the liquid solution in the cartridge is charged by direct contact. The fluid flows through an electrostatically charged conductive tube or other conduit so that the fluid is charged by the It is possible.

[0105] In some examples, battery B is a high voltage (HV) module 86 of the applicator 100; Air pump 83, circuit board 64, target sensor 45, motor 90, user interface 87. One or more processors (e.g., a central processing unit (CPU)), and a car tridge 50 can be powered. As will be described in more detail below For example, other features that can eliminate the need for button 35, including an accelerometer, activation input from a user device, etc., can be included in applicator 100.

[0106] The applicator housing 10 is sized and positioned to receive the housing 49 of the disposable cartridge 50, as will be described in more detail below ridge 50, and can include a cartridge chamber 27 (see FIGS. 2A, 2B, 3, 4A, 4B). The cartridge chamber 27 can include a distal stepped portion 29 that can connect the connection ports of the internal components of the housing 10 to the aspects of the cartridge 50 (e.g., an air supply port). In the examples shown in FIGS. 1A, 1B, and 1C, the cartridge chamber 27 is located at the top of the gun-shaped hand-held held cordless reusable applicator 100, but the cartridge chamber 402 does not have to be located in such a way. For example, the cartridge chamber 27 can be located on the side of the applicator 100 (e.g., on the side of the housing 10 of the applicator 100, or any other location). In some aspects, the HV module 8 6 can include electrical components for powering the components used to charge and spray the liquid solution of the cartridge 50. For example, the HV module 86 can supply electricity from the voltage wire 92c through the port 92a of the cartridge 50 to the wire 92d to control the voltage applied to the liquid solution of the cartridge 50, and / or It is possible to include components used to supply electricity to operate the plunger 71 (or the syringe 70 including advancing the plunger 71) so as to control the flow rate of the liquid solution passing from the cartridge 50 through the nozzle assembly 60. It is possible to include components used to supply electricity to operate the plunger 71 (or the syringe 70 including advancing the plunger 71) for the purpose of generating a positive high voltage and / or a negative high voltage. It can be done.

[0107] In some embodiments, the HV module 86 can be configured to adjust or control the operating mode of the cartridge 50, including but not limited to frequency, duty cycle, and input voltage so as to generate an output voltage that varies with different efficiencies. In some embodiments, the HV module 86 can be a closed-loop system that monitors the output voltage and adjusts the input parameters to optimize the output to a desired voltage for use in the cartridge 50 It can be done. In some embodiments, the HV module 86 can be configured to adjust or control the operating mode of the cartridge 50, including but not limited to frequency, duty cycle, and input voltage so as to generate an output voltage that varies with different efficiencies. In some embodiments, the HV module 86 can be a closed-loop system that monitors the output voltage and adjusts the input parameters to optimize the output to a desired voltage for use in the cartridge 50 It can be done. In some embodiments, the HV module 86 can be a closed-loop system that monitors the output voltage and adjusts the input parameters to optimize the output to a desired voltage for use in the cartridge 50 It can be done. The HV module 86 can also be configured to generate positive and / or negative high voltages using the same substrate. In some embodiments, the HV module 86 can include a double-sided printed circuit board to minimize the installation area used within the housing 10 It can be done. In some embodiments, the HV module 86 can include a dedicated module for generating positive high voltage It can be done. In some embodiments, the HV module 86 can include a dedicated module for generating positive high voltage It can be done. In some embodiments, the HV module 86 can include a dedicated module for generating positive high voltage It can be done. In some embodiments, the HV module 86 can include a dedicated module for generating positive high voltage In some embodiments, the HV module 86 includes a plurality of diodes configured to physically rotate (e.g., rotate by about 180°) In some embodiments, the diodes can be rotated or configured to adjust their orientation based on the operating instructions of the system It can be done. When rotating in this way, in this example, the HV module 86 can generate a positive high voltage and a negative high voltage according to the orientation of the rotatable diodes of the HV module 86 It can be done. When rotating in this way, in this example, the HV module 86 can generate a positive high voltage and a negative high voltage according to the orientation of the rotatable diodes of the HV module 86 It can be done. When rotating in this way, in this example, the HV module 86 can generate a positive high voltage and a negative high voltage according to the orientation of the rotatable diodes of the HV module 86 configured to reverse the polarity of the diode in the calculator stage. In some aspects, the HV module 86 can include a first positive high voltage multiplier system and a second negative high voltage multiplier system physically separate from the first positive high voltage multiplier system. Each subsystem of the HV module 86 can be disposed on the same circuit board and can be selectively operable during operation of the applicator 100 as needed. In some aspects, each of the subsystems can be disposed on a separate circuit board.

[0108] The applicator 100 can include one or more processors, such as a CPU, to facilitate startup of the applicator 100, reception and output of signals regarding voltage, flow rate, proximity, etc. of a particular liquid treatment solution.

[0109] Within the housing 10, the applicator 100 can include a piston 94 and a corresponding motor 90 that actuates the syringe 70. The piston 94 can be disposed between the motor 90 and the HV wall 93. The cartridge 50 can be disposed on the opposite side of the HV wall 93 when attached to chamber 2 7 of the housing 10. In some aspects, when the cartridge 50 is disposed as shown in FIG. 3, other aspects within the barrel of the plunger, piston, or syringe 70 of the cartridge 50 can be advanced through the HV wall 93 by the piston 94 and the contents of the cartridge 50 can be advanced through the nozzle assembly 60. In some aspects, the motor 90 can be disposed within portion 31 adjacent to the user interface 87. In some aspects, the motor 90 is a stepper motor It can be aタ, a worm drive motor, a solenoid, etc. The speed of the motor 90 can be adjusted based on aspects such as the preferred flow rate of a specific liquid solution discharged by the nozzle assembly 60 of the cartridge 50.

[0110] As shown in FIG. 3, the housing 10 can include a voltage wire 92c that contacts the voltage contact 92e of the HV module 86 and the cartridge voltage contact 92a of the HV wall 93. When the cartridge 50 is assembled within the chamber 27 of the housing 10, it is electrically connected to the voltage contact 92a via the cartridge HV contact 46 (see FIGS. 4B, 5A, and 5B). During operation, the wire 92c provides an electrical connection between the voltage supply of the high-voltage module 86 powered by the battery B. Inside the portion 32 of the housing 20 (e.g., below the chamber 27), an air pump 83 is connected to the supply end of an air supply tube 81. When the cartridge 50 is assembled into the chamber 27, the air supply tube 81 then supplies air to the air supply tube 76 of the cartridge 50 to provide air for spraying the charged droplets. The air supply of the air pump 83 can provide a high-speed air supply without the need for a separate air hose. In other embodiments, the housing 10 can be connected to an external air hose that provides an air supply for spraying.

[0111] The applicator 100 can include a display screen having its user interface 87, which can include a liquid crystal (LCD) and / or a light-emitting diode (LED) display. The display screen of the user interface 87 allows the operator of the applicator 100 to Information regarding the status of the applicator 100 including the operating parameters of the cartridge 50 can be made receivable. For example, the display screen of the user interface 87 can display information regarding what kind of liquid solution is contained in the disposable cartridge 50 connected to the applicator 100. As described above, this information can be written to the built-in memory of the disposable cartridge 50, and the CPU of the applicator 100 can receive this information and display this information to the operator of the applicator 100 in this way. In some embodiments, the user interface 87 displays a welcome animation and displays whether an electrostatic applicator is connected to the user device (as will be described later), displays whether the applicator 100 is properly grounded, displays whether the disposable cartridge 50 is mounted in the cartridge chamber 27, and can display which parameters (e.g., flow rate, voltage supply, droplet size, intended target, intended patient condition, recommended proximity, etc.) are being used for a particular liquid solution.

[0112] In some examples, the display screen of the user interface 87 can also have touch screen functionality. For example, the user interface 87 can function as an actuator to start or control the voltage supply to the voltage wire 92d of the cartridge 50, start or control the air flow to the air supply tube 76, and / or start or control the plunger 71 of the syringe 70 to discharge fluid from the syringe 70 through the nozzle assembly 60 to the ring 70. This will be described in more detail below. ​​​​​So that the actuator 35 (e.g., a mechanical trigger, switch, actuator, and / or a graphical user interface configured to receive input from a user and perform one or more related operations) and / or other starting mechanisms including signals from external user devices can be used to

[0113] Referring to FIG. 4A, a front perspective view of the cartridge 50 is provided, and FIG. 4B shows a rear perspective view of the cartridge 50. Similarly, FIG. 5A shows a rear lower perspective view of the cartridge 50. FIG. 5B shows a side view of the cartridge with a part of its outer housing 49 removed, and FIG. 5C shows an exploded perspective view of the internal components of the cartridge 50 with the outer housing 49 removed. FIG. 5B also shows a detailed view of the nozzle housing 60a. In some embodiments, the entire housing 60a can be formed as a single integral part and / or molded (e.g., insert molded) from multiple parts or portions. The nozzle housing 60a can include a nozzle outlet channel 62 at a distal end that can be funnel- shaped and sized and positioned to accommodate the outlet end of the

[0114] delivery tube 61. The nozzle housing 60a can include an air inlet port 66 that is in fluid communication with the nozzle end of the air One side of 9 (e.g., the distal end of port 69) can include a contact portion through which wire 92d can pass to contact delivery tube 61. At the other end of port 69 (e.g., the proximal end of port 69), the cavity associated with port 69 can be tubular to frictionally secure the outer surface of voltage tube 92. The nozzle exit channel of housing 60a described above can be disposed at the distal end of housing 60a, receive air from port 66 and fluid from delivery tube 61, and discharge droplets charged by voltage wire 92d. In some embodiments, wire 92d can electrostatically charge the contents within delivery tube 61 and the fluid contents proximal thereto (e.g., the contents within barrel portion 72 of syringe 70). As shown in FIGS. 5B and 5C, voltage wire 92d can include one or more curved surfaces (e.g., at least one downward curve connecting through tube 92 and port 69 and contacting delivery tube 61). Wire 92d can include any number of shapes including, but not limited to, an S-shape or a serpentine shape. To facilitate the shape of wire 92d, tube 92 can include one or more curves or bends as shown. For example, at the other end of port 69 (e.g., the proximal end of port 69), the cavity associated with port 69 can be tubular to frictionally secure the outer surface of voltage tube 92. For example, at the other end of port 69 (e.g., the proximal end of port 69), the cavity associated with port 69 can be tubular to frictionally secure the outer surface of voltage tube 92. For example, at the other end of port 69 (e.g., the proximal end of port 69), the cavity associated with port 69 can be tubular to frictionally secure the outer surface of voltage tube 92. The nozzle exit channel of housing 60a described above can be disposed at the distal end of housing 60a, receive air from port 66 and fluid from delivery tube 61, and discharge droplets charged by voltage wire 92d. The nozzle exit channel of housing 60a described above can be disposed at the distal end of housing 60a, receive air from port 66 and fluid from delivery tube 61, and discharge droplets charged by voltage wire 92d. The nozzle exit channel of housing 60a described above can be disposed at the distal end of housing 60a, receive air from port 66 and fluid from delivery tube 61, and discharge droplets charged by voltage wire 92d. In some embodiments, wire 92d can electrostatically charge the contents within delivery tube 61 and the fluid contents proximal thereto (e.g., the contents within barrel portion 72 of syringe 70). In some embodiments, wire 92d can electrostatically charge the contents within delivery tube 61 and the fluid contents proximal thereto (e.g., the contents within barrel portion 72 of syringe 70). As shown in FIGS. 5B and 5C, voltage wire 92d can include one or more curved surfaces (e.g., at least one downward curve connecting through tube 92 and port 69 and contacting delivery tube 61). As shown in FIGS. 5B and 5C, voltage wire 92d can include one or more curved surfaces (e.g., at least one downward curve connecting through tube 92 and port 69 and contacting delivery tube 61). As shown in FIGS. 5B and 5C, voltage wire 92d can include one or more curved surfaces (e.g., at least one downward curve connecting through tube 92 and port 69 and contacting delivery tube 61). Wire 92d can include any number of shapes including, but not limited to, an S-shape or a serpentine shape. Wire 92d can include any number of shapes including, but not limited to, an S-shape or a serpentine shape. To facilitate the shape of wire 92d, tube 92 can include one or more curves or bends as shown.

[0115] Housing 49 can be formed from a multi-part shell having alignment grooves 55 that can engage alignment tabs 25 of cartridge chamber 27. Housing 49 can be formed and / or assembled in several ways including, but not limited to, machining, molding, injection molding, three-dimensional printing, or any other suitable manufacturing process. Housing 49 can be formed from a multi-part shell having alignment grooves 55 that can engage alignment tabs 25 of cartridge chamber 27. Housing 49 can be formed from a multi-part shell having alignment grooves 55 that can engage alignment tabs 25 of cartridge chamber 27. Housing 49 can be formed and / or assembled in several ways including, but not limited to, machining, molding, injection molding, three-dimensional printing, or any other suitable manufacturing process. Housing 49 can be formed from a multi-part shell having alignment grooves 55 that can engage alignment tabs 25 of cartridge chamber 27. Housing 49 can be formed and / or assembled in several ways including, but not limited to, machining, molding, injection molding, three-dimensional printing, or any other suitable manufacturing process. Materials suitable for housing 49 can include glass-filled nylon, glass-filled polypropylene, glass-filled polyethylene, polypropylene, polyethylene, or one or more of plastic materials. In some examples, housing 49 can include two or more portions of a moldable plastic hook, such as a first half and a second half. The portions of housing 49 can be assembled with fasteners (e.g., screws, rivets, welding “such as sonic welding”, one or more straps or snaps, adhesives or adhesive tapes, etc.) so that internal components are disposed between the portions of housing 49 and / or their respective halves. In some aspects, housing 49 can include a housing spray exit associated with nozzle assembly 60 that enables discharging a charged treatment solution from cartridge 50.

[0116] Groove 55 can engage tab 25 to align housing 49 with cartridge chamber 27 properly. Housing 49 can include one groove 55 disposed on both sides of cartridge 50. Groove 55 can include an open proximal end 55p and a closed distal end 55d. When end 55d of groove 55 is adjacent to or facing nozzle assembly 60, end 55d prevents tab 25 from sliding deeper into groove 55. In some aspects, proximal end 55p can be on the opposite side of end 55d and can include an open funnel shape or tapered shape to facilitate alignment and engagement between groove 55 and tab 25.

[0117] Figure 4B specifically shows the supply end and the contact end of the cartridge 50. The HV contact 46 may be a contact port embedded in the HV wall 54 and / or may be disposed on a surface of the cartridge HV wall 54 configured to be attached to the HV wall 93 of the housing 10. The HV wall 54 may also include an intake port 47 that can be configured to couple to a corresponding intake port 147 of the HV wall 93 (see, for example, FIGS. 7A and 7B). As shown in FIGS. 3 and 5A, the cartridge 50 may also include an air supply port 59 configured to receive the air supply tube 81 and place the tubes 81, 76, and the pump 83 in fluid communication with each other. The air supply port 59 may be disposed in a stepped portion of the housing 49 having a shape corresponding to the stepped portion 29 of the housing 49. The supply port 59 of the air supply tube 81 extends at least partially from the housing 49 and may have a shape such that it is inserted into the stepped portion 29 or the air supply port 29a of the applicator housing 10 adjacent thereto. In some embodiments, the air supply tube 76 of the cartridge 50 and the air supply tube 81 of the housing 10 can include a combination of both a flexible material and a rigid material (e.g., nylon braiding). In some embodiments, the air supply tube 76 of the cartridge 50 and the air supply tube 81 of the housing 10 can be manufactured from a flexible and fluid-tight material such as an elastomer, rubber, silicon, polyvinyl chloride, etc. In some embodiments, the air supply tube 76 of the cartridge 50 and the air supply tube 81 of the housing 10 can also include a softer and more flexible fluid-tight material and / or one or more rigid materials (e.g., metal, alloy, etc.). It may be a contact port embedded in the HV wall 54 and / or may be disposed on a surface of the cartridge HV wall 54 configured to be attached to the HV wall 93 of the housing 10. It may be disposed on a surface of the cartridge HV wall 54 configured to be attached to the HV wall 93 of the housing 10. The HV wall 54 may also include an intake port 47 that can be configured to couple to a corresponding intake port 147 of the HV wall 93 (see, for example, FIGS. 7A and 7B). (See, for example, FIGS. 7A and 7B). As shown in FIGS. 3 and 5A, the cartridge 50 may also include an air supply port 59 configured to receive the air supply tube 81 and place the tubes 81, 76, and the pump 83 in fluid communication with each other. configured to receive the air supply tube 81 and place the tubes 81, 76, and the pump 83 in fluid communication with each other. include an air supply port 59 The air supply port 59 may be disposed in a stepped portion of the housing 49 having a shape corresponding to the stepped portion 29 of the housing 49. The supply port 59 of the air supply tube 81 extends at least partially from the housing 49 and may have a shape such that it is inserted into the stepped portion 29 or the air supply port 29a of the applicator housing 10 adjacent thereto. In some embodiments, the air supply tube 76 of the cartridge 50 and the air supply tube 81 of the housing 10 can include a combination of both a flexible material and a rigid material (e.g., nylon braiding). In some embodiments, the air supply tube 76 of the cartridge 50 and the air supply tube 81 of the housing 10 can include a combination of both a flexible material and a rigid material (e.g., nylon braiding). In some embodiments, the air supply tube 76 of the cartridge 50 and the air supply tube 81 of the housing 10 can include a combination of both a flexible material and a rigid material (e.g., nylon braiding). In some embodiments, the air supply tube 76 of the cartridge 50 and the air supply tube 81 of the housing 10 can include a combination of both a flexible material and a rigid material (e.g., nylon braiding). In some embodiments, the air supply tube 76 of the cartridge 50 and the air supply tube 81 of the housing 10 can be manufactured from a flexible and fluid-tight material such as an elastomer, rubber, silicon, polyvinyl chloride, etc. In some embodiments, the air supply tube 76 of the cartridge 50 and the air supply tube 81 of the housing 10 can be manufactured from a flexible and fluid-tight material such as an elastomer, rubber, silicon, polyvinyl chloride, etc. In some embodiments, the air supply tube 76 of the cartridge 50 and the air supply tube 81 of the housing 10 can also include a softer and more flexible fluid-tight material and / or one or more rigid materials (e.g., metal, alloy, etc.). and / or one or more rigid materials (e.g., metal, alloy, etc.). Can be insert molded and / or overmolded in combination 。

[0118] When firmly engaged with the chamber 27, the cartridge 50 can be released by the release button 57 and. As shown in FIGS. 5A, 5B, and 6, the button 57 can at least partially penetrate the lower surface 53 of the housing 49 through the opening in the lower surface 53 of the housing 49 and. The button 57 can be connected to, for example, a portion of the syringe 70 and can be a latch that can be removed from the cartridge 50 when the cartridge 50 is ready to be attached to the housing 10 and. This can indicate to the user that the cartridge 50 has not yet been used and that the contents therein (e.g., a liquid treatment solution) have not been used and. In some examples, the contents stored in the syringe 70 can be sterilized, and the release button 57 can indicate that the contents of the disposable cartridge 50 have been sterilized and have not been used (e.g., have not yet been used by a previous patient) and. In some embodiments, the button 57 can prevent the contents therein from advancing before use of the syringe 70 and any of its components and. In some embodiments, the button 57 can include a near field communication (NFC) tag from which the user can read cartridge identification information and other operating parameters indicating that the cartridge 50 has not yet been used and that the contents therein (e.g., a liquid treatment solution) have not been used and. In some embodiments, the button 57 can include a near field communication (NFC) tag from which the user can read cartridge identification information and other operating parameters indicating that the cartridge 50 has not yet been used and that the contents therein (e.g., a liquid treatment solution) have not been used and. In some embodiments, the button 57 can include a near field communication (NFC) tag from which the user can read cartridge identification information and other operating parameters indicating that the cartridge 50 has not yet been used and that the contents therein (e.g., a liquid treatment solution) have not been used and. In some embodiments, the button 57 can include a near field communication (NFC) tag from which the user can read cartridge identification information and other operating parameters indicating that the cartridge 50 has not yet been used and that the contents therein (e.g., a liquid treatment solution) have not been used and. In some embodiments, the button 57 can include a near field communication (NFC) tag from which the user can read cartridge identification information and other operating parameters indicating that the cartridge 50 has not yet been used and that the contents therein (e.g., a liquid treatment solution) have not been used and. In some embodiments, the button 57 can include a near field communication (NFC) tag from which the user can read cartridge identification information and other operating parameters indicating that the cartridge 50 has not yet been used and that the contents therein (e.g., a liquid treatment solution) have not been used and. In some embodiments, the button 57 can include a near field communication (NFC) tag from which the user can read cartridge identification information and other operating parameters indicating that the cartridge 50 has not yet been used and that the contents therein (e.g., a liquid treatment solution) have not been used and. In some embodiments, the button 57 can include a near field communication (NFC) tag from which the user can read cartridge identification information and other operating parameters indicating that the cartridge 50 has not yet been used and that the contents therein (e.g., a liquid treatment solution) have not been used and. In some embodiments, the button 57 can include a near field communication (NFC) tag from which the user can read cartridge identification information and other operating parameters indicating that the cartridge 50 has not yet been used and that the contents therein (e.g., a liquid treatment solution) have not been used and.

[0119] As also shown in FIGS. 5A, 5B, and 6, the cartridge 50 has its housing 4 accommodate the above-mentioned air supply tube 76, voltage tube 92, and syringe 70 therein , and / or can at least partially surround them. The syringe 70 can be an assembly including a glass or plastic syringe for storing a liquid solution to be applied using the disposable cartridge 50. The syringe 70 can be pre-filled with the desired liquid solution and then assembled into the disposable cartridge 50 . At the proximal end, the syringe 70 can include a movable plunger 71, a movable stopper 71a, and a barrel portion 72 extending distally therefrom. The plunger 71 and the stopper 71a are configured to advance within the barrel 72 so as to advance the contents of the barrel portion 72 through a luer lock 74 disposed at the distal end of the portion 72. The inner distal delivery tube 61 can extend distally from the luer lock 74 through the nozzle assembly 60 . The delivery tube 61 can be generally tube-shaped with a blunt distal tip. However, the delivery tube 61 is not so limited and may include a piercing tip. The delivery tube 61 is preferably in the range of about 15 gauge (outer diameter 0.072 inches, inner diameter 0.054 inches) to about 30 gauge (outer diameter 0.01225 inches and inner diameter 0.00625 inches). At the distal end of the luer lock 74, the distal end of the voltage wire 92d extends through the nozzle tube 92 and can be connected to the proximal portion of the inner distal delivery tube 61 which can be composed of one or more conductive materials. The wire 92d can include a needle-like structure made of one or more conductive materials (e.g., metal) capable of generating an electric field for charging the liquid solution flowing from the syringe 70 through the nozzle assembly 60. Moveable ​​​​​​ During operation, syringe 70 delivers the liquid solution stored at a predetermined rate from the barrel portion 72 through the delivery tube 61 and ultimately sprays it through the nozzle assembly 60 onto a treatment site (e.g., the wound site of a patient).

[0120] In some embodiments, voltage wire 92d can be electrically connected to a voltage source at one end (e.g., port 46) and to a nozzle tube (e.g., nozzle tube 92d) at the nozzle end as shown in FIGS. 5B and 5C. Although not shown, in some embodiments, contact 46 can communicate directly electrically with the syringe 70 configuration (e.g., directly connected to the plunger 71) rather than passing wire 92d from port 46 to tube 61. Voltage wire 92d can be substantially axially aligned along syringe 70 within disposable cartridge 50. Nozzle tube 92 can be arranged such that the nozzle end of wire 92d electrically charges the contents of syringe 70 (e.g., by contacting the delivery tube 61 when removing the distal luer lock 74) prior to delivery from nozzle assembly 60. For example, the distal end of the luer lock 74 through which delivery tube 61 passes can be electrically connected to the distal end of wire 92d as shown in FIG. 5B, and the opposite end (contact end 46) of voltage wire 92d can be electrically connected to contact end 92a of HV module 86, wire 92c, and port 92e. In some embodiments, a wire loop or hook of wire 92d can contact the delivery tube 61. In some embodiments, a wire loop or wire The hook of ear 92d can include one or more conductive materials such as copper, steel, or any other metal alloy. In some embodiments, the inner diameter of the wire loop or the hook of wire 92d can be configured to enable contact with the delivery tube 61. In some embodiments, the voltage wire 92d can be attached (e.g., spot welded, crimped, etc.) to a predetermined position and then potted with a high dielectric adhesive. The wire loop or the hook of wire 92d can at least partially surround the outer surface of the delivery tube 61 and provide a potential thereto.

[0121] In some examples, the NFC tag of the disposable cartridge 50 and / or other internal memory of the cartridge 50 can include other information regarding the contents stored therein (e.g., liquid treatment solution, recommended operating parameters, tracking information, expiration date, etc.). This information can be used, for example, by the applicator 100 not only to monitor the type and volume of the contents, but also to change the voltage, flow rate, recommended travel distance (i.e., proximity) for a particular solution. In some examples, this information can be stored in built-in memory including, but not limited to, RAM, ROM, EPROM, EEPROM, etc. The information on the built-in memory 120 can be relayed to the applicator 100 via the built-in memory and / or the NFC tag, and this information can be used to adjust or control the configuration of the cartridge (e.g., components of the syringe 70 such as the stopper 71a, flow rate, air intake from the pump 83, voltage applied to the delivery tube 61 by the wire 92d, etc.). In some embodiments, the applicator ​ One or more processors of the cartridge 100 can read information of the NFC tag or other internal memory of the cartridge 50 related to the operating parameters of the cartridge 50, and display the read NFC information (for example, information such as identification information of the contents of the cartridge 50, capacity information, etc.) on the display screen. In some embodiments, the operating information can be written to NFC by the processor of the electrostatic applicator system.

[0122] The distal end of the tube 92 can be configured to physically connect to the port 69 of the nozzle assembly 60. Similarly, the air supply tube 76 can extend from the cartridge air port 59 to the nozzle air port 66 of the nozzle assembly 60. The tube 76 can supply high-speed air for spraying the contents of the cartridge 50 (for example, the contents placed in the syringe 70) to the treatment site. The distal end of the tube 76 via the port 66 can be the outlet of the air supply tube 76 for providing a high-speed air flow to the nozzle assembly 60.

[0123] In some embodiments, one or more accumulators (not shown) can be disposed within the disposable cartridge 50 or the housing, such that one or more accumulators are configured to receive, store, and release energy during operation of the disposable cartridge 50. Examples of one or more accumulators that can be considered for use with the disposable cartridge 50 can include one or more springs, flywheel energy storage mechanisms, batteries, capacitors, etc.

[0124] ​​​​​​​​​​​​​​​Referring to FIG. 6, spring 106 (e.g., a spring that can latch in a deployable manner) can communicate with the cartridge side of button 57 . During operation, spring 106 can provide a spring bias to hold button 57 in the closed position, as shown in the enlarged cross-sectional view of portion 6 of FIG. 3 shown in FIG. 6 . In some embodiments, button 57 disposed with spring 106 in FIG. 6 can be a living hinge configured to maintain button 57 in the closed holding position shown . A solenoid 115 can be provided on the housing side of housing 10 . In FIG. 6, solenoid 115 is shown in the non-energized position. Solenoid plunger 117 is provided within solenoid 115 and can include a return spring . A solenoid plunger tip 113 can be provided at the distal end of plunger 117 . As can be seen, a rigid housing catch 109 is provided to hold button 57 in the closed configuration by solenoid 115, including plunger 117 and tip 113 . The example shown in FIG. 6 is merely one way to provide easy and secure attachment and removal of cartridge 50 to housing 10 of applicator 100, and other attachment techniques for use with the disposable cartridge 50 of the present disclosure are contemplated . . . . . .

[0125] FIG. 7A shows an exemplary enlarged cross-sectional view of the side of HV wall 93 when cartridge 50 is not connected to housing 10, and FIG. 7B shows an exemplary aspect of HV wall 93 when cartridge 50 is connected to housing 10 . In FIG. 7A, the aspect of HV wall 93 with respect to air intake and air exhaust is closed with respect to housing 10 . Specifically . In terms of, port 147 can include an air passage that finally opens to port 47 of cartridge 50 through HV wall 93. Although the related piping of port 147 is not shown, during use, the piping is provided between port 147 and pump 83. Port 147 can include an actual valve seal housing that can nest the intake port 93a of HV wall 93. In some embodiments, the valve seal conical spring can be arranged to urge the corresponding valve seal 143 to a sealed closed position, as shown in FIG. 7A. In FIG. 7B, cartridge 50 is shown coupled to HV wall 93. Specifically, port 47 of cartridge 50 is inserted into port 93a, thereby showing that seal 143 is urged to an open configuration. Now, air can pass through seal 143 and enter cartridge 50 here. It can include an air passage that opens. Although the related piping of port 147 is not shown, during use, the piping is provided between port 147 and pump 83. Port 147 can include an actual valve seal housing that can nest the intake port 93a of HV wall 93. In some embodiments, the valve seal conical spring can be arranged, as shown in FIG. 7A, to urge the corresponding valve seal 143 to a sealed closed position. In FIG. 7B, cartridge 50 is shown coupled to HV wall 93. Specifically, port 47 of cartridge 50 is inserted into port 93a, thereby showing that seal 143 is urged to an open configuration. Now, air can pass through seal 143 and enter cartridge 50 here.

[0126] FIG. 8A shows a side cross-sectional view of an exemplary embodiment of actuator 35 shown in FIGS. 1A, 1B, 1C, 2A, 2B, 3 above. Specifically, actuator 35 can include a switch base 35a configured to directly couple to an embodiment of housing 10. In some embodiments, base 35a can be coupled to flexible boot 35f and can be directly coupled to switch cap 35c. One or more switch contacts 35b are arranged within base 35a and can communicate with switch return spring 35d and switch short-circuit contact 35e. In some embodiments, actuator 35 can be configured to withstand high-pressure water and high water splashes (e.g., IP6X waterproof and dustproof rating). In some embodiments, flexible boot 35f surrounds the components of actuator 35 and is sealed. Specifically, actuator 35 can include a switch base 35a configured to directly couple to an embodiment of housing 10. In some embodiments, base 35a can be coupled to flexible boot 35f and can be directly coupled to switch cap 35c. One or more switch contacts 3 5b are arranged within base 35a and can communicate with switch return spring 3 5d and switch short-circuit contact 3 5e. In some embodiments, actuator 35 can be configured to withstand high-pressure water and high water splashes (e.g., IP6X waterproof and dustproof rating). In some embodiments, flexible boot 35f surrounds the components of actuator 35 and is sealed. It is configured to enable movement while maintaining closure.

[0127] Figure 8B shows a side cross-sectional view of another exemplary actuator 35' that can be used in the examples of the previous Figures 1A, 1B, 1C, 2A, 2B, 3. The previous flexible boot 3 5f is replaced by a flexible internal bellows boot 35' disposed inside the switch cap 35c and directly coupled to the base 35a. In some embodiments, the flexible internal bellows boot 35' is configured to surround the return spring 35d and the contact 35e so as to withstand high-pressure water and intense water splashes (e.g., IP6X waterproof and dustproof rating).

[0128] Referring to Figure 9A, a front perspective view of a cartridge 250 configured for electrospinning is provided, and Figure 9B shows a rear perspective view of the cartridge 250. The embodiment of the cartridge 250 includes numbers indicating similar structural elements and features as in the cartridge 50. In some embodiments, the nozzle 260 of the cartridge 250 is configured to receive a source liquid from the syringe 270 and supply high-pressure compressed air through one or more injection holes 267 such that the source liquid for the fibers is injected together with air and a voltage is applied thereto to generate and eject electrospun fibers having a fine diameter. In some embodiments, the holes 267 can be arranged and formed radially around the tube 261. Figure 9B specifically shows the supply end and the contact end of the cartridge 250. The HV contact 246 is disposed on a surface of the HV wall 254 of the cartridge configured to be attached to the HV wall 93 of the housing 10. The HV wall 254 also has a corresponding intake port of the HV wall 93 It can include an intake port 247 that can be configured to couple to 147 (see, for example, FIGS. 7 A and 7B).

[0129] Similarly, FIG. 10A shows a rear lower perspective view of the cartridge 250. FIG. 10B shows a side view of the cartridge with a portion of the outer housing 249 removed, and FIG. 10C shows an exploded perspective view of the internal components of the cartridge 250 with the outer housing 249 removed. Similar to the housing 49, the housing 249 can be formed and / or assembled in several ways including, but not limited to, machining, molding, injection molding, three-dimensional printing, or any other suitable manufacturing process. Suitable materials for the housing 249 can include one or more of glass-filled nylon, glass-filled polypropylene, glass-filled polyethylene, polypropylene, polyethylene, or plastic materials. As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266. As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266. As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266. As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266. As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266. As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266. As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266. As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266.

[0130] As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266. As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266. As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266. As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266. As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266. As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266. As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266. As shown in FIGS. 9A, 10B, and 10C, the nozzle assembly 260 can include a nozzle housing 260a. The nozzle housing 260a can include a nozzle outlet channel 262 at a distal end that can accommodate the outlet end of the delivery tube 261. The nozzle housing 260a can include an air inlet port 266 in fluid communication with holes 267 disposed around the channel 262. As shown in FIG. 9A, the housing 260a can include six holes radially disposed around the common axis of the channel 262, although fewer or more holes can be used as needed. In some embodiments, the holes 267 completely surround the channel 262 and are similarly in fluid communication with the port 266. It can be replaced with an outer concentric exit channel. During use, the air pumped from port 266 and exiting through hole 267 can form an air curtain around the electrospun fibers being discharged from tube 261. In the example illustrated in FIG. 9A, hole 267 has a generally linear shape such that the corresponding air curtain shapes are similarly parallel and / or axially aligned, or is inclined parallel to and / or axially aligned with tube 261 in an inclined shape. In other examples, hole 267 is inclined upward with respect to the longitudinal axis of tube 261 so as to form an outwardly funnel-shaped tapered air curtain. In other examples, hole 267 is inclined downward with respect to the longitudinal axis of tube 261 so as to form an inwardly converging tapered air curtain.

[0131] In some examples, housing 249 can include two or more pieces of moldable plastic, e.g., a first half and a second half (which, when assembled together, are referred to herein as housing 249). The two or more pieces can be assembled with fasteners (e.g., screws, rivets, welding “e.g., ultrasonic welding”, one or more straps or snaps, adhesives or adhesive tapes, etc.) such that internal components are disposed between portions of housing 249 and / or the respective halves. In some aspects, housing 249 can include a fiber exit associated with nozzle assembly 260 that enables the atomized, charged treatment solution to be discharged from cartridge 250. Port 247 receives air supply tube 81, and tube 81 ... ... , 76 and the pump 83 are configured to be in fluid communication with each other.

[0132] Similar to the cartridge 50, the cartridge 250 can engage firmly with the chamber 27 Although not shown, the cartridge 250 can house an air supply tube, a voltage tube, and a syringe 270 within its housing 249. Similar to the syringe 270, the syringe 270 can be an assembly that includes a glass or plastic syringe for storing the liquid solution to be applied using the disposable cartridge 250. , an air supply tube, a voltage tube, and a syringe 270. Similar to the syringe 270, the syringe 270 can be an assembly that includes a glass or plastic syringe for storing the liquid solution to be applied using the disposable cartridge 250. Similar to the syringe 270, the syringe 270 can be an assembly that includes a glass or plastic syringe for storing the liquid solution to be applied using the disposable cartridge 250. Although not shown, the cartridge 250 can house an air supply tube, a voltage tube, and a syringe 270 within its housing 249. Similar to the syringe 270, the syringe 270 can be an assembly that includes a glass or plastic syringe for storing the liquid solution to be applied using the disposable cartridge 250. The syringe 270 can be pre-filled with the desired liquid solution and then assembled into the disposable cartridge 250. At the proximal end, the syringe 270 can include a plunger and a barrel portion 272 that extends distally therefrom. Although not shown, the cartridge 250 can house an air supply tube, a voltage tube, and a syringe 270 within its housing 249. Similar to the syringe 270, the syringe 270 can be an assembly that includes a glass or plastic syringe for storing the liquid solution to be applied using the disposable cartridge 250. The syringe 270 can be pre-filled with the desired liquid solution and then assembled into the disposable cartridge 250. At the proximal end, the syringe 270 can include a plunger and a barrel portion 272 that extends distally therefrom. The contents of the syringe 270 can be advanced through a Luer lock 274 disposed at the distal end of the portion 272. The inner distal delivery tube 261 can extend distally through the Luer lock 274 to the nozzle assembly 260. The syringe 270 can be pre-filled with the desired liquid solution and then assembled into the disposable cartridge 250. At the proximal end, the syringe 270 can include a plunger and a barrel portion 272 that extends distally therefrom. The inner distal delivery tube 261 can extend distally through the Luer lock 274 to the nozzle assembly 260. At the distal end of the Luer lock 274, the distal end of a voltage wire (not shown, similar to the wire 92d of the cartridge 50) can extend through the nozzle tube of the cartridge 250 and connect to the proximal portion of the inner distal delivery tube 261 that can be composed of one or more conductive materials. The syringe 270 can be pre-filled with the desired liquid solution and then assembled into the disposable cartridge 250. At the proximal end, the syringe 270 can include a plunger and a barrel portion 272 that extends distally therefrom. The inner distal delivery tube 261 can extend distally through the Luer lock 274 to the nozzle assembly 260. At the distal end of the Luer lock 274, the distal end of a voltage wire (not shown, similar to the wire 92d of the cartridge 50) can extend through the nozzle tube of the cartridge 250 and connect to the proximal portion of the inner distal delivery tube 261 that can be composed of one or more conductive materials. The inner distal delivery tube 261 can extend distally through the Luer lock 274 to the nozzle assembly 260. At the distal end of the Luer lock 274, the distal end of a voltage wire (not shown, similar to the wire 92d of the cartridge 50) can extend through the nozzle tube of the cartridge 250 and connect to the proximal portion of the inner distal delivery tube 261 that can be composed of one or more conductive materials. During operation, the syringe 270 can be configured to deliver electrospun fibers from the stored liquid solution at a predetermined rate through the delivery tube 261 and ultimately release them through the nozzle assembly 260 to the treatment site (e.g., the wound site of a patient). During operation, the syringe 270 can be configured to deliver electrospun fibers from the stored liquid solution at a predetermined rate through the delivery tube 261 and ultimately release them through the nozzle assembly 260 to the treatment site (e.g., the wound site of a patient). During operation, the syringe 270 can be configured to deliver electrospun fibers from the stored liquid solution at a predetermined rate through the delivery tube 261 and ultimately release them through the nozzle assembly 260 to the treatment site (e.g., the wound site of a patient). Although not shown, the cartridge 250 can house an air supply tube, a voltage tube, and a syringe 270 within its housing 249. Similar to the syringe 270, the syringe 270 can be an assembly that includes a glass or plastic syringe for storing the liquid solution to be applied using the disposable cartridge 250.

[0133] In some examples, the NFC tag of the disposable cartridge 250 described above and / or Other internal memory of cartridge 250 stores the contents stored therein (e.g., liquid processing This information may include other information about the applicator 10, such as the placement solution. 0 allows you to monitor the type of contents, their volume, as well as for specific solutions It can also be used to change the voltage, flow rate, recommended travel distance (i.e., proximity), etc. In some cases, this information can be stored in RAM, ROM, EPROM, or EEPROM. The internal memory may include, but is not limited to, The information on the built-in memory 120 can be read by the applicator via the built-in memory and / or the NFC tag. 100, and this information can be used to determine aspects of the cartridge (e.g., the configuration of the syringe 270). can be used to regulate or control a number of different

[0134] FIG. 11A illustrates the exemplary electrostatic application of FIGS. 1A, 1B, 1C, 2A, 2B, and 3. The internal components of another exemplary electrostatic cartridge 350 contemplated for use in the cartridge. FIG. 11B shows a perspective view of the basic configuration, in which the components include a pair of syringes and an electrostatic nozzle. 11B shows a side cross-sectional view of the exemplary internal components shown in FIG. For illustrative purposes to view the components, the outer housing of cartridge 350 is shown in FIG. A and 11B. In contrast to the cartridges 50 and 250 described above. Additionally, cartridge 350 includes within its housing a multi-plunger syringe 370. This allows each sub-syringe of the multi-plunger syringe 370 to have its own The body may include an air supply tube, a voltage tube 392, a barrel portion 372, a stopper 371a, and a syringe actuating shaft 371. The actuating shaft 371 of the multi-plunger syringe 370 is connected proximally via a central drive surface 371b such that the forward surface 371b advances each of the respective stoppers 371a simultaneously, urging the contents stored in each of the respective portions 372 distally and ultimately advancing them to each of the nozzle assemblies 360. In some embodiments, the voltage tube 392 and each respective voltage wire (not shown) of the examples shown in FIGS. 11A and 11B can include separate independent high voltage inputs. In some embodiments, the examples of FIGS. 11A and 11B increase the production of treatable solutions (e.g., electrically sprayed contents, electrospun fibers, etc.) deliverable therefrom and are configured to more rapidly cover a wider area via a plurality of nozzle assemblies having separate and independent high voltages across the fluid path as shown. In some embodiments, the syringe 370 can be configured such that the sub-assemblies are distributed in different ratios other than 1:1. Only two sub-assemblies are shown in FIGS. 11A and 11B, but it is contemplated that more than two sub-assemblies can be used if desired.

[0135] FIG. 12A shows a perspective view of the internal components of another exemplary electrostatic cartridge 450 that can be used with the exemplary electrostatic applicators of FIGS. 1A, 1B, 1C, 2A, 2B, 3. The components include a pair of , shows a side cross-sectional view of exemplary internal components shown in FIG. 12A. Strictly speaking, for the purpose of illustration to observe these internal components, the outer housing of the cartridge 450 is not shown in FIGS. 12A and 12B. In some embodiments, the examples of FIGS. 12A and 12B increase the production of a treatment solution (e.g., electrosprayed contents, electrospun fibers, etc.) deliverable therefrom and, as shown, cover a wider area more rapidly via a plurality of nozzle assemblies having separated and independent high voltages across the fluid path. In some embodiments, the first sub-assembly of the syringe 470 can include a rod 471, a stopper 471a, a barrel portion 472, a luer lock 474, and a nozzle assembly 460, which are collectively configured for electrospraying. In some embodiments, the second sub-assembly of the syringe 470 can include a rod 471', a stopper 471a', a barrel portion 472', a luer lock 474', and an electrospinning tube 461', which are collectively configured for electrospraying. In some embodiments, the syringe 470 can be configured such that the sub-assemblies are distributed in different ratios other than 1:1. In some embodiments, the use of each of the first and second sub-assemblies of the syringe 470 is advantageous for utilizing both electrospraying and electrospinning with a single cartridge. In some embodiments, the barrel portions 472 and 472' can be configured to contain different volumes and / or types of fluid solutions. For the purpose of illustration to observe these internal components, the outer housing of the cartridge 450 is not shown in FIGS. 12A and 12B. In some embodiments, the examples of FIGS. 12A and 12B increase the production of a treatment solution (e.g., electrosprayed contents, electrospun fibers, etc.) deliverable therefrom and, as shown, cover a wider area more rapidly via a plurality of nozzle assemblies having separated and independent high voltages across the fluid path. In some embodiments, the examples of FIGS. 12A and 12B increase the production of a treatment solution (e.g., electrosprayed contents, electrospun fibers, etc.) deliverable therefrom and, as shown, cover a wider area more rapidly via a plurality of nozzle assemblies having separated and independent high voltages across the fluid path. In some embodiments, the examples of FIGS. 12A and 12B increase the production of a treatment solution (e.g., electrosprayed contents, electrospun fibers, etc.) deliverable therefrom and, as shown, cover a wider area more rapidly via a plurality of nozzle assemblies having separated and independent high voltages across the fluid path. In some embodiments, the examples of FIGS. 12A and 12B increase the production of a treatment solution (e.g., electrosprayed contents, electrospun fibers, etc.) deliverable therefrom and, as shown, cover a wider area more rapidly via a plurality of nozzle assemblies having separated and independent high voltages across the fluid path. In some embodiments, the first sub-assembly of the syringe 470 can include a rod 471, a stopper 471a, a barrel portion 472, a luer lock 474, and a nozzle assembly 460, which are collectively configured for electrospraying. In some embodiments, the first sub-assembly of the syringe 470 can include a rod 471, a stopper 471a, a barrel portion 472, a luer lock 474, and a nozzle assembly 460, which are collectively configured for electrospraying. In some embodiments, the first sub-assembly of the syringe 470 can include a rod 471, a stopper 471a, a barrel portion 472, a luer lock 474, and a nozzle assembly 460, which are collectively configured for electrospraying. In some embodiments, the second sub-assembly of the syringe 470 can include a rod 471', a stopper 471a', a barrel portion 472', a luer lock 474', and an electrospinning tube 461', which are collectively configured for electrospraying. In some embodiments, the second sub-assembly of the syringe 470 can include a rod 471', a stopper 471a', a barrel portion 472', a luer lock 474', and an electrospinning tube 461', which are collectively configured for electrospraying. In some embodiments, the second sub-assembly of the syringe 470 can include a rod 471', a stopper 471a', a barrel portion 472', a luer lock 474', and an electrospinning tube 461', which are collectively configured for electrospraying. In some embodiments, the syringe 470 can be configured such that the sub-assemblies are distributed in different ratios other than 1:1. In some embodiments, the syringe 470 can be configured such that the sub-assemblies are distributed in different ratios other than 1:1. In some embodiments, the use of each of the first and second sub-assemblies of the syringe 470 is advantageous for utilizing both electrospraying and electrospinning with a single cartridge. In some embodiments, the use of each of the first and second sub-assemblies of the syringe 470 is advantageous for utilizing both electrospraying and electrospinning with a single cartridge. In some embodiments, the barrel portions 472 and 472' can be configured to contain different volumes and / or types of fluid solutions.

[0136] In contrast to the cartridges 50 and 250 described above, the cartridge 450 has its housing... The syringe can include a multi - plunger syringe 470 within the housing, such that each sub - syringe of the multi - plunger syringe 470 can include its own air supply tube, voltage tube 492, barrel portions 472, 472', stoppers 471a, 471a', and syringe rods 471, 471'. The shafts 471, 471' of the multi - plunger syringe 470 are connected proximally via a central drive surface 471b such that the forward surface 471b simultaneously advances each connected rod 471, 471' against its respective stopper 471a, 471a' to distally bias the contents stored in each respective portion 472, 472' through each respective luer lock 47 4, 474' and ultimately advance them to each nozzle assembly. In some embodiments, the voltage tube 492 and respective voltage wires (not shown) of the example shown in FIGS. 12A and 12B can include separate independent high - voltage inputs. Only two sub - assemblies are shown in FIGS. 12A and 12B, but it is contemplated that more than two sub - assemblies can be used if desired. In some aspects, although FIGS. 12A and 12B show only two sub - assemblies, it is contemplated that more than two sub - assemblies can be used if desired.

[0137] FIG. 13A shows a perspective view of the internal components of another exemplary electrostatic cartridge 550 that can be used in the exemplary electrostatic applicator of FIGS. 1A, 1B, 1C, 2A, 2B, 3. The components include a pair of syringes and an electrostatic nozzle. FIG. 13B shows a side cross - sectional view of the exemplary internal components shown in FIG. 13A. Strictly for the purpose of illustration of observing these internal components, the outer housing of the cartridge 550 is not shown in FIGS. 13A and 13B. In contrast to the cartridges 50 and 250 described above, ​​​​​​​​​​​In addition, the cartridge 550 can include a multi - plunger syringe 570 within its housing, such that each sub - syringe of the multi - plunger syringe 570 can include its own air supply tube, voltage tube 592, barrel portion 572, stopper 571a, and syringe rod 571. The actuating shaft 571 of the multi - plunger syringe 570 can be connected proximally via a central drive surface 571b such that the forward surface 571b simultaneously advances each respective stopper 571a of the connected rods 571 to urge distally the contents stored in each respective portion 572 and ultimately advance each respective nozzle assembly 560.

[0138] In the example of FIGS. 13A and 13B, each of the barrel portion 572 and the corresponding sub - assembly structure can be interconnected by a Y - shaped delivery needle 561. As shown, the tube 561 includes proximal ports in fluid communication with each luer lock 574 and the barrel portion 572, joins at a single distal end, and can release or discharge a solution therethrough. The voltage tube 592 and the corresponding voltage wire (not shown) can be joined to the delivery tube 561 proximal to the most distal end of the tube 561 such that all solutions released from the delivery tube 561 are charged by the voltage wire. Although a Y - shaped member is shown, any number of syringe sub - assemblies can be used in the cartridge 550 as needed. In some In some embodiments, the examples of Figures 13A and 13B may include: of deliverable treatment solutions therefrom (e.g., electrosprayed contents, electrospun fibers, etc.) Increases production and provides separate, independent high-pressure flow throughout the entire fluid path, as shown. To cover a larger area more quickly through multiple nozzle assemblies with voltage In some embodiments, the syringe 570 is configured such that the subassembly is other than 1:1. The two sub-ports can be configured to dispense in different ratios. Although only one subassembly is shown, more than two subassemblies can be used if desired. It is believed that it can be used.

[0139] FIG. 14A illustrates the nozzle assembly disclosed herein of the disposable cartridge described. FIG. 6 illustrates a side perspective view of an exemplary cone 607, 603 configured for use in any of the In some embodiments, a cone 603 is attached to the distal end of the nozzle assembly. or a physical cone of any material that is attached directly to the housing 10. In some embodiments, the cone 607 may be associated with each nozzle assembly. In some embodiments, the cone 6 can be attached directly to the distal end of the delivery tube. 03 by preventing interference from external airflow and / or external forces, respectively. The system (e.g., the applicator 100 and any disposable carts connected thereto) Discharge of electrosprayed or electrospun material from the implant (e.g., the implant ridge) to the treatment site (e.g., the wound site of the patient). In some embodiments, the cone 603 can be configured to protect the Controls airflow within each nozzle assembly by reflecting spray off the cone walls. It can be configured to be manipulated. In some embodiments, when the housing 10 and / or each nozzle assembly are attached, the cone 603 can be configured such that one or more lights (e.g., LED lights) surround the proximal end of the cone from the electrostatic applicator, and a light pattern (e.g., a light ring) can be generated through a light pipe effect on the target site to assist in aiming. In some embodiments, if a translucent material is used for the cone 603, the cone can disperse light from the applicator 100 containing different colors, and when the applicator is too close or too far, it can notify the user of the appropriate distance by means of a warning.

[0140] FIG. 14B shows a side perspective view of another exemplary cone 703 configured to be used in any of the nozzle assemblies disclosed in the present specification of the described disposable cartridge. In some embodiments, the cone 703 can be a physical cone of any material that is attached to the distal end of the nozzle assembly or directly attached to the housing 10. Similarly, the cone 703 can be illuminated when a solution is being discharged therefrom. For example, the inner surface 709 of the cone 703 can be configured to be illuminated or plated or finished with a non-stick surface.

[0141] FIG. 14C shows a side perspective view of another exemplary cone 803 configured to be used in any of the nozzle assemblies disclosed in the present specification of the described disposable cartridge. In some embodiments, the cone 803 can be a physical cone of any material that is attached to the distal end of the nozzle assembly or directly attached to the housing 10. or a physical cone of any material that is directly attached to the housing 10 is acceptable. In some embodiments, the inner surface 809 of the cone 803 can be plated or finished with a conductive surface that has the same polarity as the fluid being dispensed, which aids in the dispensing direction. The distal edge 808 of the cone 803 can be left without such plating and / or finishing of the same conductive surface.

[0142] FIG. 14D shows a side perspective view of another exemplary cone 903 configured for use in any of the nozzle assemblies disclosed herein for the described disposable cartridge. In some embodiments, the cone 903 is a physical cone of any material that is attached to the distal end of the nozzle assembly or directly attached to the housing 10. is acceptable. In some embodiments, the inner surface 909 of the cone 903 can be plated or finished with a plurality of conductive surfaces (e.g., radially separated surfaces) that can be charged to repel and / or attract the solution and change the dispensing direction.

[0143] FIGS. 15, 16, and 17 are block diagrams of various components and systems that can be included in an electrostatic applicator system (e.g., within applicator 100 and / or any of disposable cartridges 50, 250, 350, 450, 550) according to the present disclosure. A controller 1500, which can include a CPU, can communicate with various components and systems to operate the electrostatic applicator. For example, the controller 1 500 can receive information regarding a particular fluid contained within the cartridge in order to It can communicate with a disposable cartridge. This information communicated to the controller 1500 (e.g., via a built-in memory) can include information regarding, for example, a preferred fluid flow rate (by adjusting the motor speed) so that preferred nanoparticles can be formed from the therapeutic solution to be sprayed, an air supply rate, and a voltage (e.g., by adjusting the potential between the voltage supply unit (e.g., HV module 86) and the delivery tube of each nozzle assembly of each cartridge ridge). With this information, a single reusable applicator 100 can be used with a number of different disposable cartridges 50, 250, 350, 450, 550 having different solutions. Further, not only can the fluids within each disposable cartridge 50, 250, 350, 450, 550 potentially be different. For example, different disposable cartridges 50, 250, 350, 450, 550 can have different air supply tubes, voltage wires, and / or nozzle assemblies depending on the specific use of the disposable cartridge 50, 250, 350, 450, 550. For this purpose, this component information can also be relayed to the controller 1500 so that the reusable applicator 100 can be adjusted accordingly. The controller 1500 can communicate with a sensor subsystem 1502 that includes various sensors that can be used to operate the reusable applicator 100. The sensor subsystem 1502 can include an accelerometer 1504 that can be

[0144] used to wake up the CPU when the user moves the reusable applicator 100. For example, any button or capacitive input from the associated user interface described above. Additionally or alternatively, the reusable applicator 100 may include a reusable accelerometer. It can automatically turn on when it detects movement of an available electrostatic applicator (e.g. (For example, the CPU can receive power.) The sensor subsystem 1502 To determine whether the cartridge is fully attached to the chamber 27, The cleavage detection unit 1506 may be disposed adjacent to the cleavage chamber 27. The unit 1506 is configured to load the disposable cartridge before the applicator 100 can be operated. Ensure that the 50, 250, 350, 450, and 550 are fully seated within the chamber 27. The cleavage detector 1506 can function as a safety measure to ensure that the pressure sensor The input / output terminal may be a switch, a power supply, or the like.

[0145] The sensor subsystem 1502 detects the presence of a target area on the reusable applicator 100 . A proximity sensor 1508 may be included to detect how close the device is to a location. The cartridge 1508 may be attached to the distal end of the reusable applicator 100, e.g., Place close to or adjacent to the spray outlet of Ridge 50, 250, 350, 450, 550 Alternatively, the proximity sensor 1508 may be, for example, Use close to or adjacent to the 50, 250, 350, 450, or 550 housing spray outlet. It can be placed on the discardable cartridge 50, 250, 350, 450, 550. The proximity sensor 1508 may include an inductive proximity sensor, a capacitive proximity sensor, a photoelectric proximity sensor, etc. The proximity sensor 1508 can detect the presence of a capacitive applicator on a target. used to indicate to the operator whether the device is within a preferred distance to the target (e.g., configured to detect the proximity between an electrostatic applicator and the target), a safety function can be provided. For example, the travel distance of the charged droplets can affect the shape of the droplets when they contact the target site. For this purpose, the proximity sensor 1508 can send a signal indicating the distance to the target object to the controller 1500, and the controller 15 00 can send a signal to warn the user if the device is too far or too close to the target site to the user interface 1536 (e.g., a display screen, an external user device, etc.). This information can be based on the information stored in the built-in memory of the disposable cartridges 50, 250, 350, 450, 550 as described above.

[0146] The sensor subsystem 1502 can include a gyroscope 1510 (or gyroscope) used to assist in measuring or maintaining a specific positioning of the reusable applicator 100. For example, the gyroscope 1510 can output a signal to the user interface 1536 (e.g., a display screen, an external user device, etc.) to indicate to the user that the device should be moved to an upright configuration or any other configuration. The sensor subsystem 1502 can also include the above- mentioned handle grounding portion 1426. In addition to grounding the operator, the handle grounding portion 1426 can be used to detect whether the user is holding the device and whether the device should be activated.

[0147] The controller 1500 can be used to operate the reusable applicator 100 as desired and communicate with a control subsystem 1514 that includes various sensors, switches, etc. The control subsystem 1514 can include a cartridge temperature sensor 1516. The disposable cartridges 50, 250, 350, 450, 550 can be considered to be stored and used at room temperature, but the cartridges can also be stored in a frozen state under other conditions, for example, to preserve the therapeutic solution stored therein. The cartridge temperature sensor 1516 can detect the temperature of the therapeutic solution and warn the user if the solution is too cold or too hot to be administered to the patient's skin.

[0148] The control subsystem 1514 can include a pressure sensor 1518 arranged to read the air pressure of the air flow entering each cartridge through an air supply (e.g., the air supply associated with the pump 83). This pressure information can be used by the controller 1500 to determine whether the air flow through the device provides a preferred air velocity for the particular fluid being sprayed. The control subsystem 1514 can include a flow meter 1520 arranged to read the fluid flow rate of the fluid passing through or exiting the nozzles of each cartridge 50, 250, 350, 450, 550. This flow rate information can be used by the controller 1500 to determine whether the fluid flow rate through the device provides the correct volume for the particular solution being sprayed.

[0149] The control subsystem 1514 can include a motor limit switch 1522.​​​​​​​​ The motor limit switch 1522 can be used to define the speed at which the piston of the applicator is actuated and further define and / or adjust the flow rate of the treatment solution. The control subsystem 1514 can include a voltmeter 524. The voltmeter 524 can be used to measure the voltage applied to the nozzle tube 106. If the voltage is off for some reason for a particular fluid, a warning can be sent to the user interface 1536 (e.g., the display screen of the user interface 87, an external user device, etc. ). )

[0150] In some embodiments, the control subsystem 1514 includes or can communicate with a cartridge detection switch configured to detect the presence of a cartridge when assembled with an electrostatic applicator . If the presence is detected, one or more operations associated with each cartridge can be performed or initiated. In some embodiments, the control subsystem 1514 can include or communicate with an NFC chip of a disposable cartridge, whereby the NFC chip contains information regarding the characteristics of the contents stored within and / or in the syringe of the cartridge (e.g., treatment solution), such as motor speed or applied voltage to the contents to be applied from the cartridge and / or the electrostatic applicator to the treatment site, whether the cartridge is sealed or unsealed, flow rate, potential, and / or nozzle settings associated with the nozzle, etc., of the contents of the cartridge.

[0151] The controller 1500 can also receive a signal indicating whether the grounding strap 424 is attached to an external ground (e.g., the patient's wound site and / or target). If not attached to an external ground, the controller 1500 sends a warning to the user interface 1536 and / or prohibits the activation of the reusable applicator 100 (e.g., by preventing the electrical connection between the voltage supply of the HV module 86 and the respective nozzles of the cartridges 50, 250, 350, 450, 550 via a switch, for example). The controller 1500 can also communicate with the charger system 1530 . As described above, the voltage supply 420 can include one or more rechargeable batteries. The charger system 1530 can include an AC / DC converter(s) and / or an inductive integrated circuit(s) to manage the charging of the rechargeable voltage supply of the HV module 86 . The controller 1500 can also communicate with the communication subsystem 1532. The communication subsystem 1532 can be built into the CPU and / or the HV module 86 and can include one or more transceivers capable of communicating with an external device . The one or more transceivers can be compatible with short-range wireless communication connections, such as, but not limited to , radio frequency identification (RFID), near field communication (NFC), Bluetooth (trademark

[0152] ), low energy Bluetooth (trademark) (BLE), WiFi (trademark), ZigBee (trademark), and / or similar connections . The communication subsystem 1532 can include one or more transceivers capable of communicating with an external device. The one or more transceivers can be compatible with short-range wireless communication connections, such as, but not limited to , radio frequency identification (RFID), near field communication (NFC), Bluetooth (trademark ), low energy Bluetooth (trademark) (BLE), WiFi (trademark), ZigBee (trademark) , and / or similar connections. 2 enables the reusable applicator 100 to communicate with an external device such as a user device. The user device can include a mobile cellular device, a personal digital assistant (PDA), a tablet, a laptop or desktop computer, a smart wearable device, etc. In this example, the user device can operate similarly to a display screen to provide information to the device operator. For example, in addition to or instead of a display screen, the display screen of the user device can be used. Wireless communication between the reusable applicator 100 and the user device can provide the option of using the user device as an actuator to initiate the spraying sequence of an electrostatic applicator. For example, the activation input to the controller 1500 (or CPU) can include providing an input on the display screen of an external user device.

[0153] Furthermore, information about the fluid in the disposable cartridges 50, 250, 350, 450, 550 can be input into the user device to notify the controller 1500 of which spraying parameters should be used for a particular cartridge. In some examples, barcodes, quick response (QR) codes, etc. can be placed on the disposable cartridges 50, 250, 350, 450, 550. The user can scan the code with a camera or other scanner on the user device, and the information can be relayed to the controller 1500. The controller 1500 can then determine the spraying parameters required for a particular cartridge. The user can then enter an activation input (e.g., By pressing an icon on the screen of the user device, the spraying of the treatment solution can be started .

[0154] Referring again to FIG. 15, the controller 1500 can communicate with a user interface 1536 that can provide information to the operator of the reusable applicator 100 and receive information from the operator of the reusable applicator . FIG. 16 provides a detailed configuration diagram of an exemplary user interface 1536. The user interface 1536 can include the display screen of the user interface 87 described above. For example , the user interface 1536 can include an LCD / LED screen 1538 for providing information about the status of the device to the user. In some examples, the user interface 1536 can include a display touch panel 1540 . In an example where the user interface 1536 (e.g., the previous user interface 87) is the display screen on the reusable applicator 100, the display screen can include touch screen functionality . Thereby, the display screen may be capable of receiving a startup input for starting the spraying sequence of the reusable applicator 100. For example, the display screen can provide an icon that can function as a virtual "actuator" for starting the spraying sequence . Further, to inform the controller 1500 (or CPU) of which parameters should be used for a particular treatment solution, information about the fluid contained in the specific disposable cartridges 50 , 250, 350, 450, 550 can be input into this display touch panel 1540 . . . . . . . . . .

[0155] The user interface 1536 can include a buzzer 1542. The buzzer 15 42 can indicate to the operator whether a problem should be addressed regarding the device 1 or can include one or more speakers. For example, when the disposable cartridges 50, 25 0, 350, 450, 550 are not fully seated, the grounding portion of the applicator 100 (e.g., the grounding strap 1424 or the handle grounding portion 1426) does not detect proper grounding or when the voltage supply of the HV module 86 is low power or should be charged etc., the buzzer 1542 can provide audible feedback regarding a particular state Furthermore, the display screen of the user interface 87 can also provide visual feedback to further warn the user about a particular problem In addition, or instead, the user interface 1536 can include a vibration motor 1544 that can indicate to the user via tactile feedback when a problem occurs The user interface 1536 can include a start / stop button 1546 Instead, the start / stop button 1546 can be incorporated into a display screen, such as the display screen of the user interface 8 7 or the display screen on an external user device, so as to be able to execute the startup of the device within the screen having touch screen functionality The user interface 1536 can include an actuator 1555 (e.g., a trigger) As described above, the actuator 1555 can be an actuator, a virtual actuator within the user interface of an external user device, or a virtual actuator as an icon within the display screen of the user interface 8 7 The actuator 1555 can be a virtual actuator within the user interface of an external user device, or a virtual actuator as an icon within the display screen of the user interface 8 7 or can be a virtual actuator as an icon within the display screen of the user interface 8 7

[0156] FIG. 17 is a configuration diagram of an exemplary controller 1500 according to the present disclosure. As described above the controller 1500 can include one or more processors such as, for example, a CPU The CPU can be a microprocessor, a microcontroller, a digital signal processor, a coprocessor etc., and / or one or more of combinations thereof that can execute stored instructions and operate based on data The CPU can be configured as a single-core or a multi-core processor that executes parallel processing simultaneously For example, the CPU can be a single-core processor configured with virtual processing technology The CPU can use logical processors to execute and control multiple processes simultaneously and control.

[0157] The controller 1500 can include a memory 1560. The memory 1560 is communicable with one or more processors (e.g., the CPU). The memory 1560 can include instructions to cause the CPU and / or the controller 1500 to complete any of the processes described herein, such as, for example, program 1580 or other applications For example, the memory 1560 can cause the controller 1500 and / or the CPU to receive a start signal from (e.g., from a manual trigger, from an external user device, from the display screen of the user interface 87 etc.), and a control signal (e.g., related to actuating the bias of the solution exiting through the respective nozzles from the respective cartridges) to actuate the delivery of fluid from syringes 70, 270, 370, 470, 570 to actuate motors and / or pistons Output a control signal to the ton, and from the voltage supply source of the HV module 86 to each voltage wire Output a control signal to the switch to supply voltage to the wire (for example, wire 92d). It can include instructions.

[0158] In some implementations, the memory 1560 stores files including an operating system, application programs, executable instructions, and data, using one or more appropriate types of memory (for example, volatile or non-volatile memory, random access memory (RAM), read-only memory (ROM), programmable read-only memory (PROM), erasable programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), magnetic disk, optical disk, floppy disk, hard disk, removable cartridge, flash memory, redundant array of independent disks (RAID), etc.). It can include such. The memory 1560 can also include a program containing instructions for completing the processes described herein, for example, it can include program 1580. For example, program 1580 receives a trigger signal (for example, from an actuator of the applicator 100, or from an external user device, and / or from a virtual trigger on the display screen of the user interface 87), outputs a first control signal to the motor to operate the pistons related to the operation of each cartridge, and / or includes instructions to output a second control signal to the switch to supply voltage to the voltage wire from the voltage supply unit of the HV module 86. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution Or more appropriate types of memory (for example, volatile or non-volatile memory, random access memory (RAM), read-only memory (ROM), programmable read-only memory (PROM), erasable programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), magnetic disk, optical disk, floppy disk, hard disk, removable cartridge, flash memory, redundant array of independent disks (RAID), etc.).) can be included. The memory 1560 can also include a program containing instructions for completing the processes described herein, for example, it can include program 1580. For example, program 1580 receives a trigger signal (for example, from an actuator of the applicator 100, or from an external user device, and / or from a virtual trigger on the display screen of the user interface 87), outputs a first control signal to the motor to operate the pistons related to the operation of each cartridge, and / or includes instructions to output a second control signal to the switch to supply voltage to the voltage wire from the voltage supply unit of the HV module 86. It can be included. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution One or more appropriate types of memory (for example, volatile or non-volatile memory, random access memory (RAM), read-only memory (ROM), programmable read-only memory (PROM), erasable programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), magnetic disk, optical disk, floppy disk, hard disk, removable cartridge, flash memory, redundant array of independent disks (RAID), etc.).) can be included. The memory 1560 can also include a program containing instructions for completing the processes described herein, for example, it can include program 1580. For example, program 1580 receives a trigger signal (for example, from an actuator of the applicator 100, or from an external user device, and / or from a virtual trigger on the display screen of the user interface 87), outputs a first control signal to the motor to operate the pistons related to the operation of each cartridge, and / or includes instructions to output a second control signal to the switch to supply voltage to the voltage wire from the voltage supply unit of the HV module 86. It can be included. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution Memory (RAM), read-only memory (ROM), programmable read-only memory (PROM), erasable programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), magnetic disk, optical disk, floppy disk, hard disk, removable cartridge, flash memory, redundant array of independent disks (RAID), etc.).) can be included. The memory 1560 can also include a program containing instructions for completing the processes described herein, for example, it can include program 1580. For example, program 1580 receives a trigger signal (for example, from an actuator of the applicator 100, or from an external user device, and / or from a virtual trigger on the display screen of the user interface 87), outputs a first control signal to the motor to operate the pistons related to the operation of each cartridge, and / or includes instructions to output a second control signal to the switch to supply voltage to the voltage wire from the voltage supply unit of the HV module 86. It can be included. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution Memory (PROM), erasable programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), magnetic disk, optical disk, floppy disk, hard disk, removable cartridge, flash memory, redundant array of independent disks (RAID), etc.).) can be included. The memory 1560 can also include a program containing instructions for completing the processes described herein, for example, it can include program 1580. For example, program 1580 receives a trigger signal (for example, from an actuator of the applicator 100, or from an external user device, and / or from a virtual trigger on the display screen of the user interface 87), outputs a first control signal to the motor to operate the pistons related to the operation of each cartridge, and / or includes instructions to output a second control signal to the switch to supply voltage to the voltage wire from the voltage supply unit of the HV module 86. It can be included. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution Electrically erasable programmable read-only memory (EEPROM), magnetic disk, optical disk, floppy disk, hard disk, removable cartridge, flash memory, redundant array of independent disks (RAID), etc.).) can be included. The memory 1560 can also include a program containing instructions for completing the processes described herein, for example, it can include program 1580. For example, program 1580 receives a trigger signal (for example, from an actuator of the applicator 100, or from an external user device, and / or from a virtual trigger on the display screen of the user interface 87), outputs a first control signal to the motor to operate the pistons related to the operation of each cartridge, and / or includes instructions to output a second control signal to the switch to supply voltage to the voltage wire from the voltage supply unit of the HV module 86. It can be included. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution Magnetic disk, optical disk, floppy disk, hard disk, removable cartridge, flash memory, redundant array of independent disks (RAID), etc.).) can be included. The memory 1560 can also include a program containing instructions for completing the processes described herein, for example, it can include program 1580. For example, program 1580 receives a trigger signal (for example, from an actuator of the applicator 100, or from an external user device, and / or from a virtual trigger on the display screen of the user interface 87), outputs a first control signal to the motor to operate the pistons related to the operation of each cartridge, and / or includes instructions to output a second control signal to the switch to supply voltage to the voltage wire from the voltage supply unit of the HV module 86. It can be included. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution Flash memory, redundant array of independent disks (RAID), etc.).) can be included. The memory 1560 can also include a program containing instructions for completing the processes described herein, for example, it can include program 1580. For example, program 1580 receives a trigger signal (for example, from an actuator of the applicator 100, or from an external user device, and / or from a virtual trigger on the display screen of the user interface 87), outputs a first control signal to the motor to operate the pistons related to the operation of each cartridge, and / or includes instructions to output a second control signal to the switch to supply voltage to the voltage wire from the voltage supply unit of the HV module 86. It can be included. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution The memory 1560 can also include a program containing instructions for completing the processes described herein, for example, it can include program 1580. For example, program 1580 receives a trigger signal (for example, from an actuator of the applicator 100, or from an external user device, and / or from a virtual trigger on the display screen of the user interface 87), outputs a first control signal to the motor to operate the pistons related to the operation of each cartridge, and / or includes instructions to output a second control signal to the switch to supply voltage to the voltage wire from the voltage supply unit of the HV module 86. It can be included. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution For example, it can include program 1580. For example, program 1580 receives a trigger signal (for example, from an actuator of the applicator 100, or from an external user device, and / or from a virtual trigger on the display screen of the user interface 87), outputs a first control signal to the motor to operate the pistons related to the operation of each cartridge, and / or includes instructions to output a second control signal to the switch to supply voltage to the voltage wire from the voltage supply unit of the HV module 86. It can be included. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution For example, program 1580 receives a trigger signal (for example, from an actuator of the applicator 100, or from an external user device, and / or from a virtual trigger on the display screen of the user interface 87), outputs a first control signal to the motor to operate the pistons related to the operation of each cartridge, and / or includes instructions to output a second control signal to the switch to supply voltage to the voltage wire from the voltage supply unit of the HV module 86. It can be included. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution For example, from an actuator of the applicator 100, or from an external user device, and / or from a virtual trigger on the display screen of the user interface 87), outputs a first control signal to the motor to operate the pistons related to the operation of each cartridge, and / or includes instructions to output a second control signal to the switch to supply voltage to the voltage wire from the voltage supply unit of the HV module 86. It can be included. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution ), outputs a first control signal to the motor to operate the pistons related to the operation of each cartridge, and / or includes instructions to output a second control signal to the switch to supply voltage to the voltage wire from the voltage supply unit of the HV module 86. It can be included. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution Output a first control signal to the motor to operate the pistons related to the operation of each cartridge, and / or include instructions to output a second control signal to the switch to supply voltage to the voltage wire from the voltage supply unit of the HV module 86. It can be included. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution Output a second control signal to the switch to supply voltage to the voltage wire from the voltage supply unit of the HV module 86. It can be included. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution It can be included. Further, the controller 1500, for example, controls the air flow and fluid flow of a specific treatment solution and / or be able to store data related to parameters for adjusting voltage and can include a data storage device 1590.

[0159] Figures 18, 19, 20, and 21 are flowcharts of exemplary processes for operating the reusable applicator 100 and the disposable cartridge systems 50, 250, 350, 450, 550 according to the present disclosure. Specifically, FIG. 18 is a flowchart of an exemplary process 1800 for managing the operation of the applicator 100 described herein. In process 1800, the microcontroller unit can wake up and determine whether setup data exists (step 1802). If so, the system of the applicator 100 can be woken up to execute the main task process (step 1804). The main task process in step 1804 can include a proximity task step 1808, a stepper motor task 1810, a menu task 1812, and an MCU sleep mode 1814. In some embodiments, the main task in step 1804 can start when it detects an input from an accelerometer that communicates with it (e.g., in response to detecting a predetermined change in acceleration that exceeds a threshold indicating movement of the user of the applicator 100). In some embodiments, the proximity task 1808 can start when a corresponding proximity sensor (e.g., the target sensor 45) detects that the target site is within the threshold spray range of the applicator 100. In some embodiments, the proximity task step 1808 can be related to an associated actuator (e.g., the user and can include starting in response to detecting a predetermined change in acceleration that exceeds a threshold indicating movement of the user of the applicator 100). In some embodiments, the proximity task 1808 can start when a corresponding proximity sensor (e.g., the target sensor 45) detects that the target site is within the threshold spray range of the applicator 100. In some embodiments, the proximity task step 1808 can be related to an associated actuator (e.g., the user and can include starting in response to detecting a predetermined change in acceleration that exceeds a threshold indicating movement of the user of the applicator 100). In some embodiments, the proximity task 1808 can start when a corresponding proximity sensor (e.g., the target sensor 45) detects that the target site is within the threshold spray range of the applicator 100. In some embodiments, the proximity task step 1808 can be related to an associated actuator (e.g., the user and can include starting in response to detecting a predetermined change in acceleration that exceeds a threshold indicating movement of the user of the applicator 100). The operation of the button on the display screen of the interface 87 or the capacity input) can be started and / or started by stopping.

[0160] In step 1802, if the system determines that there is no setup data, step 1806 of the setup task of the applicator 100 is executed. In some aspects, step 1806 can include the setup data to be input (e.g., via the display screen of the user interface 87). When the setup data is input, the menu task 1812 can be executed. If no operation or other input is received within a predetermined period, in step 1814, the system enters the MCU sleep mode.

[0161] FIG. 19 is a flowchart of an exemplary process 1900 that utilizes a specific aspect from process 1800. In process 1900, the microcontroller unit can wake up and initialize all systems and subsystems of the applicator 100 (step 1902). Such initialization can include starting the setup task 19 04, the menu task 1906, the main task 1908, the proximity task 1910, the step p motor task 1912, as well as other initialization tasks. After completing step 1902, a step of reading the non-volatile memory 1914 is executed. If the non-volatile memory is not empty (step 1916), the system determines whether all variables are loaded (step 1918). If all variables are loaded, the aforementioned main task 1804 of process 1800 can be executed. Steps If the non-volatile memory is empty in 1916, the system can play a welcome animation on the display screen of interface 87 (step 1922). Similarly, if it is determined in step 1918 that not all variables have been loaded , step 1922 can likewise be executed by the system. When step 1922 is completed in either situation , after waiting for a predetermined time (e.g., about 3 seconds), the previous setup task step 1806 from process 1800 can be executed.

[0162] FIG. 20 is an exemplary flowchart of process setup task 1806 of the previous process 1800 regarding starting the wireless connectivity between the exemplary applicator 100 and the wireless network.

[0163] FIG. 21 is an exemplary flowchart of process setup task 1812 of the previous process 1800 regarding starting the wireless connectivity between the applicator 100 and an external device (e.g., a mobile computing device such as a smartphone, tablet, etc.) so that the external device can control and / or monitor one or more operations of the applicator 100, including but not limited to the operation of a cartridge coupled to the applicator.

[0164] FIG. 22 is an exemplary flowchart of process main task 1804 of the previous process 1800 regarding initializing all systems and subsystems of the exemplary applicator 100. FIG. 23 is a flowchart following FIG. 22, where the ground strap is Determine and manage the operations related to the grounding strap and any associated ground signals in the existing examples. Specifically describe the exemplary sub-steps related to determining and managing. FIGS. 23 and 24 also illustrate the exemplary steps related to the operation of attaching any of the cartridges described so far to the exemplary applicator 100 of the present disclosure and managing the assembly. By way of example and not limitation, in step 2330 of FIG. 23, the position of the cartridge can be analyzed to determine whether the cartridge is properly attached. If not properly attached, an animation can be played (step 2332) until finally the MCU can be made to enter the sleep mode (step 2336). If it is determined that the cartridge is properly attached (step 2330), in step 2402, it can be determined whether the cartridge is genuine (step 2410), whether the OTP is blown (step 2412), whether the cartridge identification information conforms to or is operable with the current firmware and / or hardware of the applicator 100 (step 2422), whether the cartridge ID indicates that its contents are sterilized (step 2424), contain stem cells (step 2426), and / or are configured for electrospinning (step 2428), etc. Specific information can be determined by reading the details of the cartridge, including other aspects of each cartridge that can also be identified and evaluated in these exemplary processes. For example, other solution types, as well as the origin and destination of the cartridge, whether its contents remain completely sealed, whether the cartridge has been previously used, etc. In step 2410, it can be determined whether the cartridge is genuine. In step 2412, it can be determined whether the OTP is blown. In step 2422, it can be determined whether the cartridge identification information conforms to or is operable with the current firmware and / or hardware of the applicator 100. In step 2424, it can be determined whether the cartridge ID indicates that its contents are sterilized. In step 2426, it can be determined whether the cartridge contains stem cells. In step 2428, it can be determined whether the cartridge is configured for electrospinning. Other aspects of each cartridge can also be identified and evaluated in these exemplary processes. For example, other solution types, as well as the origin and destination of the cartridge, whether its contents remain completely sealed, whether the cartridge has been previously used, etc. used, etc. Whether it has ever been attached to an applicator, a prescription entity (e.g., a doctor or other operator requested a cartridge), and whether the cartridge is associated with a specific patient or intended use can be analyzed.

[0165] Depending on the results of the specific sub-steps of FIG. 24, the system can proceed to the process of FIG. 25, whereby steps 2502 (system setting of the disinfection medium), 2504 (system setting of the stem cell medium), and 2506 (system setting of the electrospinning medium) start the system settings in steps 2508, 2510, and 2512 respectively, and then proceed to the remaining operation tasks of the process 1800 of FIG. 18 as further shown in FIGS. 26 and 27. For example, in FIG. 27, start / stop can be set (step 2702), the OTP bits on the cartridge attached to the applicator 100 can be set (step 2704), and then the stepper of the applicator can be moved forward according to the contents (i.e., the media of the contents of each cartridge) (step 2706). Thereafter, the proximity task 1808 can be read, and if satisfied, the stepper task 1810 can be executed. In some embodiments, the results of the proximity task 1808 can be displayed on the display screen of the interface 87 and / or can be displayed by one or more LEDs associated therewith.

[0166] FIG. 28 relates to detecting and managing operations based on readings from one or more proximity sensors of the applicator 100 and related calculations, of the previous process 1800 It is a flowchart of an exemplary process proximity task 1808.

[0167] FIG. 29 is related to discharging the contents from a loaded cartridge towards a target site and is a flowchart of an exemplary process stepper task 1810 of a previous process 1800 related to the operation of a stepper motor of an applicator 100.

[0168] FIG. 30 is a flowchart of an exemplary process that can be used before executing the main task 1804 and / or to put the MCU into sleep mode (step 3020). For example, the process can include managing feedback from an accelerometer, a manual trigger, the actuation of a start / stop button, the status of a ground strap, a signal from the ground strap, the presence of a user ground, and feedback from a limit switch.

[0169] FIG. 31 is a flowchart of a method 3100 for operating an exemplary electrostatic applicator system. Step 3110 of method 3100 includes contacting a voltage contact at a first end of a voltage wire in a first disposable cartridge with a voltage contact of the electrostatic applicator system, fluidly connecting a first end of an air supply port in the first disposable cartridge with an air supply port of the electrostatic applicator system, and inserting the first disposable cartridge into a chamber housing of the electrostatic applicator system such that a plunger of a cylinder containing a first fluid in the first disposable cartridge is aligned with a piston of the electrostatic applicator system. Step 3120 of method 3100 includes operating the electrostatic applicator system. ​​​​​​​​​​​​Activating the motor by startup input to the tem and delivering a potential to the delivery tube of the first disposable cartridge can be included.

[0170] Figure 32 is a method 3200 executed by a computer for operating an electrostatic applicator system. Step 3210 of method 3200 can include activating the motor by startup input to the electrostatic applicator system and / or delivering a potential from a high voltage module of the electrostatic applicator system to a delivery tube of a disposable cartridge removably attached to a chamber housing of the electrostatic applicator system via a voltage wire of the disposable cartridge. Step 3220 of method 3200 can include advancing a fluid content of the disposable cartridge from a syringe through the delivery tube by the motor biasing a stopper of the syringe. Step 3230 of method 3200 can include electrostatically charging a fluid content within the delivery tube by the voltage wire. Step 3240 of method 3200 can include discharging the electrostatically charged fluid content from a nozzle assembly of the disposable cartridge to a treatment site.

[0171] Specific configurations, material selections, and the sizes and shapes of various elements can be changed according to specific design specifications or constraints required for a system or method constructed according to the principles of the disclosed technology. Such changes are intended to be included within the scope of the disclosed technology. Therefore, the embodiments disclosed herein are in all respects illustrative and not restrictive. ​​​​​​​​​​​​​​​It is considered to be exemplary rather than definitive. Therefore, although specific forms of the present disclosure have been illustrated and described, various modifications can be made without departing from the spirit and scope of the present disclosure and it is intended that all changes within the meaning and scope of its equivalents be included, as will be apparent from the above.

[0172] The following clauses enumerate non-limiting embodiments of the present disclosure. 1. A disposable fluid delivery system for an electrostatic applicator, comprising a nozzle housing including an air supply port, a voltage port, and a delivery outlet, a voltage wire including a contact that communicates with a delivery tube in fluid communication with the delivery outlet, the voltage wire being electrically communicative with a high voltage module and configured to electrostatically charge the fluid contents within the delivery tube, the voltage wire, a syringe including a barrel portion and a plunger configured to advance fluid from within the barrel portion through the delivery tube, and a cartridge housing at least partially surrounding the nozzle housing, the voltage wire, and the syringe a system. 2. The disposable fluid delivery system according to clause 1, further comprising a voltage tube in electrical communication with the voltage port, the voltage wire passing between a contact that communicates with the delivery tube and a contact port on the wall of the cartridge housing. 3. The disposable fluid delivery system according to clause 2, wherein the voltage tube and the voltage wire include a substantially S-shaped configuration. 4. The disposable fluid delivery system according to clause 2, wherein the voltage tube and the voltage wire include a linear configuration. 5. The disposable fluid delivery system according to clause 2, wherein the voltage tube and the voltage wire include a substantially curved configuration. ​​​​​​ 6. The disposable fluid delivery system according to clause 2, further comprising an air supply tube connected to the air supply port. 7. The disposable fluid delivery system according to clause 2, wherein the syringe contains a content including one or more of a disinfectant, a bactericidal solution, an analgesic, exosomes, a biologic, and / or a liquid bandage solution. 8. The disposable fluid delivery system according to clause 2, wherein the analgesic includes one or more of lidocaine, levobupivacaine, acemetacin, ketorolac, and cetazidime. 9. The disposable fluid delivery system according to clause 2, wherein the biologic includes one or more of stem cells and / or mammalian cells. 10. The disposable fluid delivery system according to clause 2, wherein the disinfection solution and / or the bactericidal solution includes chlorhexidine gluconate and / or povidone iodine. 11. The disposable fluid delivery system according to clause 1, wherein the cartridge housing is a formable plastic material. 12. The disposable fluid delivery system according to clause 11, wherein the cartridge housing includes a plurality of sections of formable plastic that are connectable to create a single integral component. 13. The disposable fluid delivery system according to clause 1, wherein the contact of the voltage wire includes a wire loop that at least partially surrounds the outer surface of the delivery tube and provides a potential of about 1 V to about 40 kV. 14. The disposable fluid delivery system according to clause 1, wherein the contact of the voltage wire physically contacts the outer surface of the delivery tube and provides a potential of about 1 V to about 40 kV. 15. When the delivery tube is assembled with the syringe and the nozzle housing, the air supply Receives air from the supply port, receives fluid from the barrel portion of the syringe, and to the voltage wire The disposable fluid delivery system according to claim 1, configured to discharge the fluid evenly charged thereby. Delivery system. 16. A reusable electrostatic applicator including a cartridge chamber sized and shaped to receive a cartridge housing, comprising: A high-voltage module configured to be in electrical communication with the voltage wire; A piston disposed proximate to the cartridge chamber and configured to advance a plunger enclosed within the cartridge housing when the cartridge housing is assembled with the cartridge chamber ; and A reusable electrostatic applicator including The disposable fluid delivery system according to claim 1, further comprising. The disposable fluid delivery system according to claim 1, further comprising. 17. The reusable electrostatic applicator is A motor configured to move the piston; One or more processors; When executed by one or more processors, causes the reusable electrostatic applicator To Receive a start signal, Output a control signal to the motor to operate the piston, Output a control signal to the switch to supply voltage from the high-voltage module to the voltage wire ; and A memory storing instructions The disposable fluid delivery system according to claim 16, comprising. 18. The disposable fluid delivery system according to claim 17, wherein the motor is a stepper motor, a linear actuator, a worm gear motor, and / or A planetary gear motor. 19. The disposable fluid delivery system according to claim 17, wherein the motor is a drivable actuator system that uses motion transmission by an applied force The disposable fluid delivery system according to clause 17, which is a stem. 20. The disposable fluid delivery system according to clause 17, wherein the reusable electrostatic applicator further includes a display screen, and the activation signal is a user input to the display screen. 21. The disposable fluid delivery system according to clause 17, wherein the reusable electrostatic applicator further includes an actuator, and the activation signal is a user input received by the actuator. The disposable fluid delivery system according to clause 17. 22. The reusable electrostatic applicator includes a housing base including a voltage source, a device housing including a cartridge chamber, and a handle extending between the housing base and the device housing The disposable fluid delivery system according to clause 21. 23. The cartridge chamber is disposed within the device housing such that the actuator is disposed below the cartridge chamber horizontally. The disposable fluid delivery system according to clause 22. 24. The disposable fluid delivery system according to clause 17, wherein the reusable electrostatic applicator further includes a wireless antenna, and the activation signal is a wireless signal received from a remote external user device. The disposable fluid delivery system according to clause 17. 25. An electrostatic applicator system for delivering a treatment solution to a target site, comprising a device housing configured to be handheld, a motor within the device housing configured to drive a piston, a voltage source within the device housing, a high voltage module electrically connected to the voltage source, a cartridge chamber and a portable reusable electrostatic applicator, a nozzle housing including an air supply port, a voltage port, and a delivery outlet. A voltage wire including a contact that communicates with a delivery tube in fluid communication with a delivery outlet, a barrel portion, and a plunger configured to advance fluid from within the barrel portion through the delivery tube comprising a syringe, a nozzle housing, a voltage wire, and a cartridge housing at least partially surrounding the syringe and a disposable cartridge removably insertable into a cartridge chamber including, and including a system. 26. The electrostatic applicator system according to clause 25, wherein the syringe contains a fluid containing one or more of a disinfectant, a bactericidal solution, an analgesic, exosomes, a biologic, and / or a liquid bandage solution. 27. The electrostatic applicator system according to clause 26, wherein the analgesic contains one or more of lidocaine, levobupivacaine, acemetacin, ketorolac, and ceftazidime. 28. The electrostatic applicator system according to clause 26, wherein the biologic contains one or more of stem cells and / or mammalian cells. 29. The electrostatic applicator system according to clause 25, wherein the voltage wire and the voltage tube include a voltage wire within the cartridge housing having a linear shape and / or a curved shape or a substantially S-shaped configuration. 30. The electrostatic applicator system according to clause 25, wherein the cartridge housing is a formable plastic material. 31. The electrostatic applicator system according to clause 30, wherein the cartridge housing includes a plurality of connected sections of formable plastic. 32. The cartridge chamber includes a high voltage contact in electrical communication with a high voltage module, and 33. The electrostatic applicator system according to clause 25, wherein the cartridge housing includes a plurality of connected sections of formable plastic. 34. The electrostatic applicator system according to clause 30, wherein the cartridge housing is a formable plastic material. 35. The electrostatic applicator system according to clause 30, wherein the cartridge housing includes a plurality of connected sections of formable plastic. 36. The cartridge chamber includes a high voltage contact in electrical communication with a high voltage module, and 37. The electrostatic applicator system according to clause 30, wherein the cartridge housing includes a plurality of connected sections of formable plastic. 38. The cartridge chamber includes a high voltage contact in electrical communication with a high voltage module, and including a wall including an air supply port in fluid communication with a pump disposed within a device housing see a voltage wire is in electrical communication with a high voltage contact of the wall, a contact of the voltage wire physically contacts an outer surface of the delivery tube to provide a potential of about 1 V to about 40 kV, the electrostatic applicator system according to clause 25. The electrostatic applicator system according to clause 25. 33. The electrostatic applicator system according to clause 25, comprising a plurality of rotary diodes such that the HV module is configured to generate both a positive high voltage and a negative high voltage depending on the orientation of the rotary diodes. The electrostatic applicator system according to clause 25, comprising a plurality of rotary diodes such that the HV module is configured to generate both a positive high voltage and a negative high voltage depending on the orientation of the rotary diodes. The electrostatic applicator system according to clause 25. 34. The electrostatic applicator system according to clause 25, wherein the HV module comprises a circuit board including a first positive high voltage multiplier system and a second negative high voltage multiplier system. The electrostatic applicator system according to clause 25, wherein the HV module comprises a circuit board including a first positive high voltage multiplier system and a second negative high voltage multiplier system. 35. The electrostatic applicator system according to clause 25, wherein when the delivery tube is assembled with the syringe and the nozzle housing, the delivery tube is configured to receive air from the air supply port, receive fluid from the barrel portion of the syringe, and discharge the fluid uniformly charged by the voltage wire. The electrostatic applicator system according to clause 25, wherein when the delivery tube is assembled with the syringe and the nozzle housing, the delivery tube is configured to receive air from the air supply port, receive fluid from the barrel portion of the syringe, and discharge the fluid uniformly charged by the voltage wire. The electrostatic applicator system according to clause 25, wherein when the delivery tube is assembled with the syringe and the nozzle housing, the delivery tube is configured to receive air from the air supply port, receive fluid from the barrel portion of the syringe, and discharge the fluid uniformly charged by the voltage wire. The electrostatic applicator system according to clause 25. 36. The electrostatic applicator system according to clause 25, wherein the disposable cartridge comprises an air supply tube connected to the air supply port. The electrostatic applicator system according to clause 25, wherein the disposable cartridge comprises an air supply tube connected to the air supply port. 37. The electrostatic applicator system according to clause 25, wherein the device housing includes a handle, a voltage source is disposed within the housing base of the device housing, and the handle is disposed between the device housing and the housing base. The electrostatic applicator system according to clause 25, wherein the device housing includes a handle, a voltage source is disposed within the housing base of the device housing, and the handle is disposed between the device housing and the housing base. The electrostatic applicator system according to clause 25. 38. A reusable electrostatic applicator, one or more processors, when executed by one or more processors, to the reusable electrostatic applicator, wherein, Cause a start signal to be received, (a) the potential from the high-voltage module to the delivery tube via the voltage wire, (b) the positions of the piston and plunger of the disposable cartridge, and / or (c) a pump that regulates the air flow from the device housing to the air supply port, and output a control signal to a motor that controls it A memory that stores instructions and, an electrostatic applicator system according to clause 25. 39. The disposable cartridge includes built-in memory containing information regarding one or more operating parameters of the contents stored in the syringe and / or another fluid reservoir of the disposable cartridge, and one or more processors of the reusable electrostatic applicator communicate with the built-in memory to obtain information regarding the contents of the disposable cartridge and are configured to control at least one of flow rate, potential, and nozzle settings. An electrostatic applicator system according to clause 38. 40. The disposable cartridge includes built-in memory containing information regarding the characteristics of the contents stored in the syringe and / or another fluid reservoir of the disposable cartridge, and one or more processors of the reusable electrostatic applicator communicate with the built-in memory to obtain information regarding the contents of the disposable cartridge and are configured to control motor speed, air intake, and / or applied voltage. An electrostatic applicator system according to clause 38. 41. A memory is incorporated into a processor of the electrostatic applicator system and includes operating instructions for operating the electrostatic applicator system. An electrostatic applicator system according to clause 39. ​​42. The electrostatic application according to clause 39, wherein the short-range wireless communication (NFC) tag includes a memory Cathode system. 43. The electrostatic applicator system according to clause 42, further including a display screen, wherein the activation signal is a user input to the display screen 44. The electrostatic applicator system according to clause 42, further including a display screen, and the instruction is to cause the NFC information regarding the operation parameters of the disposable cartridge to be read, and to cause the read NFC information to be displayed on the display screen 45. The electrostatic applicator system according to clause 38, further including an actuator, wherein the activation signal is a user input received by the actuator 46. The electrostatic applicator system according to clause 38, further including a wireless antenna, wherein the activation signal is a wireless signal received from an external user device 47. The electrostatic applicator system according to clause 38, further including an accelerometer configured to output a motion signal to one or more processors in response to detection of the movement of the electrostatic applicator system 48. The electrostatic applicator system according to clause 47, further including a display screen on the electrostatic applicator system that is activated by a wake signal from one or more processors in response to the one or more processors receiving the motion signal, and the activation signal is a user input to the display screen 49. The electrostatic applicator system further includes a proximity sensor configured to detect the distance between the system and an intended target, and one of the control signals is output to the motor in response to the distance being within a predetermined distance threshold ​​​​​​​​​​One of the control signals is output to a switch to control the voltage of an electrostatic applicator system in response to the distance being within a predetermined distance threshold. The electrostatic applicator system according to clause 38. The electrostatic applicator system according to clause 38. 50. The electrostatic applicator system further includes a proximity sensor configured to detect the distance between the system and the intended target, and one of the control signals is output to prevent the operation of the motor in response to the distance being greater than or less than a predetermined distance threshold. The electrostatic applicator system according to clause 38. The electrostatic applicator system according to clause 38. The electrostatic applicator system according to clause 38. 51. The electrostatic applicator system further includes a proximity sensor configured to detect the distance between the system and the intended target, and one of the control signals is output to a switch to prevent the transmission of the voltage of the electrostatic applicator system in response to the distance being greater than or less than a predetermined distance threshold. The electrostatic applicator system according to clause 38. The electrostatic applicator system according to clause 38. The electrostatic applicator system according to clause 38. The electrostatic applicator system according to clause 38. 52. A method for operating an electrostatic applicator system, comprising: The voltage contact at the first end of the voltage wire in the first disposable cartridge contacts the voltage contact of the electrostatic applicator system; The first end of the air supply port in the first disposable cartridge is in fluid connection with the air supply of the electrostatic applicator system; The plunger of the syringe containing the first fluid in the first disposable cartridge is aligned with the piston of the electrostatic applicator system; Insert the first disposable cartridge into the chamber housing of the electrostatic applicator system; Actuate the motor by an activation input to the electrostatic applicator system, and the potential The electrostatic applicator system according to clause 38. The electrostatic applicator system according to clause 38. Insert the first disposable cartridge into the chamber housing of the electrostatic applicator system; Actuate the motor by an activation input to the electrostatic applicator system, and the potential Deliver it to the delivery tube of the first disposable cartridge A method comprising: 53. By operating the motor, a first fluid is advanced through a delivery tube from a syringe and sprayed onto a target site in a predetermined spray pattern as electrostatically charged atomized fluid droplets The method according to clause 52. 54. Removing the first disposable cartridge from the chamber housing and inserting a second disposable cartridge into the chamber housing, the second disposable cartridge containing a second fluid The method according to clause 52, further comprising: 55. The second disposable cartridge is configured for electrospinning, and the method operates the motor by a second activation input to an electrostatic applicator system such that the second fluid in the syringe of the second disposable cartridge is delivered from the second fluid to a target site by the delivery tube of the second disposable cartridge and a potential is delivered to the delivery tube of the second disposable cartridge The method according to clause 54, further comprising: 56. The first disposable cartridge and the second disposable cartridge each include a built-in memory containing information about the respective operating parameters of the first fluid and the second fluid, and when either the first disposable cartridge or the second disposable cartridge is inserted into the chamber housing, the operating parameters are transmitted to the memory of the electrostatic applicator system and the operating parameters include at least one of the speed of the motor, the air intake, and the voltage applied to the delivery tube, of each disposable cartridge The method according to clause 54. 41. The method according to clause 54, wherein the operating parameters include at least one of the speed of the motor, the air intake, and the voltage applied to the delivery tube, of each disposable cartridge The method according to clause 54. 57. The method comprises: Inserting one of a first disposable cartridge or a second disposable cartridge into the chamber housing tags a registry associated with information on the operating parameters of the first disposable cartridge or the second disposable cartridge as a used cartridge, and when it is determined that the first disposable cartridge or the second disposable cartridge is a used cartridge, prevents the motor from operating and / or a potential from being delivered to the delivery tube of the first disposable cartridge or the second disposable cartridge, and further includes the method according to clause 56. 58. The method according to clause 54, wherein the first disposable cartridge and the second disposable cartridge contain different fluids. 59. The method according to clause 49, wherein the first disposable cartridge and the second disposable cartridge include at least one of different voltage wires and different delivery tubes according to their respective nozzle housings, the first fluid stored in their respective disposable cartridges, and / or the second fluid. 60. The method according to clause 52, wherein providing a startup input includes inputting information regarding the first fluid into a display screen of an electrostatic applicator system and providing an input to the display screen. 61. The method according to clause 52, further including pairing an electrostatic applicator system with an external user device via a short-range wireless connection, and providing a startup input includes inputting information regarding the first fluid into the external user device and providing an input to a display screen of the external user device. 62. A computer-implemented method for operating an electrostatic applicator system And, actuating a motor via an actuation input to the electrostatic applicator system; and and / or via the voltage wires of the disposable cartridge, the high Removable from the voltage module to the chamber housing of the electrostatic applicator system delivering an electrical potential to a delivery tube of a disposable cartridge attached to the A motor biases the plunger of the syringe, thereby forcing the syringe through the delivery tube. advancing the fluid contents of the disposable cartridge from the electrostatically charging the fluid contents in the delivery tube by a voltage wire; The electrostatically charged fluid contents are discharged from the nozzle assembly of the disposable cartridge to the treatment unit. To release it in the right place A method comprising: 63. A voltage wire is connected to the fluid in the barrel of the syringe proximal to the delivery tube. Electrostatically charging the contents 63. The computer implemented method of claim 62, further comprising: 64. The step of expelling the electrostatically charged fluid contents from the nozzle assembly comprises: The electrically charged fluid contents are atomized into droplets in a predetermined spray pattern onto a target site. As shown in Fig. 1, the air supply of the electrostatic applicator system is supplied to the disposable cartridge. 63. The computer implemented method of claim 62, comprising controlling the intake. 65. The step of expelling the electrostatically charged fluid contents from the nozzle assembly comprises: 62, including delivery as electrospun fibers from an electrically charged fluid content. The computer-implemented method described herein. 66. Detecting the distance between an electrostatic applicator system and an intended target by a proximity sensor, and in response to the distance being within a predetermined distance threshold, transmitting an activation input to operate a motor and / or deliver a potential to a high voltage module, The method executed by a computer according to clause 62, further comprising: 67. Detecting the distance between an electrostatic applicator system and an intended target by a proximity sensor, and in response to the distance being greater than or less than a predetermined distance threshold, preventing the operation of a motor and / or preventing the high voltage module from delivering a potential, The method executed by a computer according to clause 62, further comprising: 68. In response to one or more processors receiving a motion signal, activating a wake signal from one or more processors of an electrostatic applicator system by a display screen on the electrostatic applicator system, and in response to the wake signal, transmitting an activation input to operate a motor and / or deliver a potential to a high voltage module, The method executed by a computer according to clause 62, further comprising: 69. A disposable cartridge includes a built-in memory containing information about the operating parameters of the fluid contents stored in the syringe, and the method includes communicating with the built-in memory by one or more processors of a reusable electrostatic applicator to obtain information about the fluid contents of the disposable cartridge, and controlling at least one of flow rate, potential, and nozzle settings to control one or more operating parameters of the disposable cartridge. ​​​​​​​​​​ whose operating parameters include motor speed, air intake, and / or the applied voltage of a disposable cartridge and further includes the method executed by a computer according to clause 62. 70. A method executed by a computer, wherein a memory is incorporated into a processor of an electrostatic applicator system and includes operating instructions for operating the electrostatic applicator system and further includes the method executed by a computer according to clause 62. 71. A system for operating an electrostatic applicator system, comprising at least one memory storing instructions, operating a motor by a startup input to the electrostatic applicator system, and / or delivering a potential to a delivery tube of a disposable cartridge removably attached to a cartridge housing of the electrostatic applicator system from a high voltage module of the electrostatic applicator system via a voltage wire of the disposable cartridge, advancing a fluid content of the disposable cartridge from a syringe through the delivery tube by the motor biasing a plunger of the syringe, electrostatically charging the fluid content in the delivery tube by a voltage wire, and discharging the electrostatically charged fluid content from a nozzle assembly of the disposable cartridge to a treatment site and at least one processor configured to execute instructions for performing operations including and discharging the electrostatically charged fluid content from a nozzle assembly of the disposable cartridge to a treatment site and discharging the electrostatically charged fluid content from a nozzle assembly of the disposable cartridge to a treatment site and a system comprising. 72. The step of discharging the electrostatically charged fluid content from the nozzle assembly atomizes the electrostatically charged fluid content into droplets in a predetermined spray pattern onto a target site and comprises. 72. The step of discharging the electrostatically charged fluid content from the nozzle assembly atomizes the electrostatically charged fluid content into droplets in a predetermined spray pattern onto a target site and Controlling the intake of air from the air supply unit of the electrostatic applicator system into the disposable cartridge The system according to clause 71, including 73. The step of discharging the electrostatically charged fluid content from the nozzle assembly includes Delivering as electrospun fibers at a predetermined velocity onto the target site from the electrostatically charged fluid content The system according to clause 71 74. The operation includes detecting, by a proximity sensor, the distance between the electrostatic applicator system and the intended target, And in response to the distance being within a predetermined distance threshold, activating the motor and / or sending an activation input to deliver a potential to the high voltage module The system according to clause 71, further including 75. The operation includes, in response to one or more processors receiving a movement signal, activating, by a display screen on the electrostatic applicator system, a wake signal from one or more processors of the electrostatic applicator system, And in response to the wake signal, activating the motor and / or sending an activation input to deliver a potential to the high voltage module The system according to clause 71, further including 76. The disposable cartridge includes a built-in memory containing information about one or more operating parameters of the fluid content stored in the syringe, and the operation includes Communicating with the built-in memory to obtain information about the fluid content of the disposable cartridge by one or more processors of the reusable electrostatic applicator, And controlling one or more operating parameters of the disposable cartridge to control the flow rate, electricity ​​​​​​​controlling at least one of the position and the nozzle setting, the one or more operating parameters including motor speed, air intake, and / or the applied voltage of the disposable cartridge and further comprising the system according to clause 71. 77. A system according to clause 71, wherein the memory is incorporated into a processor of an electrostatic applicator system and includes operating instructions of a method executed by a computer for operating the electrostatic applicator system. 78. A non-transitory computer-readable medium storing instructions that, when executed by a processor, cause the processor to execute a method for operating an electrostatic applicator system, the method comprising: activating a motor by an activation input to the electrostatic applicator system; and delivering a potential to a delivery tube of a disposable cartridge removably attached to a system housing of the electrostatic applicator system from a high voltage module of the electrostatic applicator system via a voltage wire of the disposable cartridge; advancing a fluid content of the disposable cartridge through the delivery tube from a syringe by the motor biasing a plunger of the syringe; electrostatically charging the fluid content within the delivery tube by the voltage wire; and releasing the electrostatically charged fluid content from a nozzle assembly of the disposable cartridge to a treatment site. 79. The step of releasing the electrostatically charged fluid content from the nozzle assembly comprises spraying the electrostatically charged fluid content in a predetermined spray pattern onto a reversely charged target site. / or removably delivering a potential to a delivery tube of a disposable cartridge removably attached to a system housing of the electrostatic applicator system from a high voltage module of the electrostatic applicator system via a voltage wire of the disposable cartridge; advancing a fluid content of the disposable cartridge through the delivery tube from a syringe by the motor biasing a plunger of the syringe; advancing a fluid content of the disposable cartridge through the delivery tube from a syringe by the motor biasing a plunger of the syringe; electrostatically charging the fluid content within the delivery tube by the voltage wire; releasing the electrostatically charged fluid content from a nozzle assembly of the disposable cartridge to a treatment site; and including a non-transitory computer-readable medium. 79. The step of releasing the electrostatically charged fluid content from the nozzle assembly comprises spraying the electrostatically charged fluid content in a predetermined spray pattern onto a reversely charged target site. electrostatically charged fluid content in a predetermined spray pattern onto a reversely charged target site. Controlling the intake of air from the air supply of an electrostatic applicator system into a disposable cartridge so as to atomize into droplets, the non-transitory computer readable medium according to clause 78. 80. The step of discharging an electrostatically charged fluid content from a nozzle assembly includes delivering the electrostatically charged fluid content as electrospun fibers onto a reversely charged target site at a predetermined velocity and / or pattern, the non-transitory computer readable medium according to clause 78. 81. The method further includes detecting, by a proximity sensor, the distance between an electrostatic applicator system and an intended target, and in response to the distance being within a predetermined distance threshold, transmitting an activation input to operate a motor and / or deliver a potential to a high voltage module, the non-transitory computer readable medium according to clause 78. 82. The method further includes activating, by a display screen on an electrostatic applicator system, a wake signal from one or more processors of the electrostatic applicator system in response to one or more processors receiving a motion signal, and in response to the wake signal, transmitting an activation input to operate a motor and / or deliver a potential to a high voltage module, the non-transitory computer readable medium according to clause 78. 83. The disposable cartridge includes a built-in memory containing information regarding one or more operating parameters of a fluid content stored within a syringe, and the method includes retrieving, by one or more processors of a reusable electrostatic applicator, information regarding one or more operating parameters of a fluid content stored within a syringe from a disposable cartridge, the non-transitory computer readable medium according to clause 78. 84. The method further includes retrieving, by one or more processors of a reusable electrostatic applicator, information regarding one or more operating parameters of a fluid content stored within a syringe from a disposable cartridge, the non-transitory computer readable medium according to clause 78. 85. The disposable cartridge includes a built-in memory containing information regarding one or more operating parameters of a fluid content stored within a syringe, and the method includes retrieving, by one or more processors of a reusable electrostatic applicator, communicating with the built-in memory to obtain information regarding the fluid contents of the cartridge; controlling at least one of flow rate, electricity, and nozzle settings so as to control one or more operating parameters of the disposable cartridge, the one or more operating parameters including motor speed, air intake, and / or applied voltage of the disposable cartridge; and A non-transitory computer-readable medium according to clause 78, further comprising.​​

Claims

1. 1. A disposable fluid delivery system for an electrostatic applicator, comprising: a nozzle housing including an air supply port, a voltage port, and a delivery outlet; a voltage wire including a contact in fluid communication with a delivery tube in fluid communication with the delivery outlet, a voltage module in electrical communication with said delivery tube for electrostatically charging the fluid contents within said delivery tube; a voltage wire configured to a barrel portion and a fluid supply means for supplying fluid from within the barrel portion through the delivery tube; a syringe including a plunger configured as A housing at least partially surrounding the nozzle housing, the voltage wire, and the syringe. Cartridge housing and 1. A disposable fluid delivery system comprising:

2. a voltage tube in electrical communication with the voltage port; The voltage wire is connected to the contact that communicates with the delivery tube and the cartridge housing. The disposable fluid delivery system of claim 1 , wherein the fluid passes between the contact port in the wall of the

3. The syringe may be filled with a disinfectant, a germicidal solution, an analgesic, an exosome, a biologic, and / or 3. The disposable of claim 2, containing contents including one or more of the liquid dressing solutions. Fluid delivery system.

4. the cartridge housing being a moldable plastic material; The cartridge housing comprises a plurality of connectable sections of moldable plastic. The disposable fluid delivery system of claim 1 , comprising:

5. The contacts of the voltage wires at least partially surround an exterior surface of the delivery tube and are approximately 10. The disposable fluid delivery system of claim 1, comprising a wire loop that provides a potential of from 1 V to about 40 kV. Stem.

6. The contact of the voltage wire is in physical contact with the delivery tube and provides a voltage of about 1 V to about 40 kV.

13. The disposable fluid delivery system of claim 1, providing an electrical potential of V.

7. The delivery tube is assembled with the syringe and the nozzle housing. When the syringe receives air from the air supply port, the syringe receives fluid from the barrel portion. and configured to eject a fluid uniformly charged by the voltage wire. The disposable fluid delivery system of claim 1 .

8. A cartridge chamber sized and shaped to receive said cartridge housing. a reusable electrostatic applicator including a rechargeable battery; The reusable electrostatic applicator comprises: a high voltage module configured to be in electrical communication with the voltage wires; a piston disposed adjacent to the cartridge chamber; When the housing is assembled with the cartridge chamber, the cartridge a piston configured to advance the plunger enclosed within a housing; The disposable fluid delivery system of claim 1 , comprising:

9. The reusable electrostatic applicator comprises: a motor configured to move the piston; one or more processors; A memory for storing instructions; Equipped with The instructions, when executed by the one or more processors, For electrostatic applicators, Receive the activation signal, outputting a control signal to the motor to actuate the piston; A control signal is sent to a switch to supply voltage from the high voltage module to the voltage wire.

10. The disposable fluid delivery system of claim 8,

10. The reusable electrostatic applicator comprises: a housing base containing a voltage source; a device housing containing the cartridge chamber; a handle extending between the housing base and the device housing; The disposable fluid delivery system of claim 9 , comprising:

11. 1. An electrostatic applicator system for delivering a treatment solution to a target site, comprising: a portable, reusable electrostatic applicator; Disposable cartridges and Including, The portable, reusable electrostatic applicator comprises: A device housing configured to be handheld; a motor within the device housing configured to drive a piston; a voltage source within the device housing; a high voltage module electrically connected to the voltage source; Cartridge chamber and Including, The disposable cartridge is removably insertable into the cartridge chamber. the law of nature, The disposable cartridge comprises: a nozzle housing including an air supply port, a voltage port, and a delivery outlet; a voltage wire including a contact in communication with a delivery tube in fluid communication with the delivery outlet; a barrel portion and a fluid supply means for supplying fluid from within said barrel portion through said delivery tube; a syringe including a plunger configured as described above; At least partially surrounding the nozzle housing, the voltage wire, and the syringe. Cartridge housing and 1. An electrostatic applicator system comprising:

12. the cartridge chamber includes a wall; The wall is a high voltage contact in electrical communication with the high voltage module; an air supply port in fluid communication with a pump disposed within the device housing; Including, the voltage wire is in electrical communication with the high voltage contact on the wall; The contact of the voltage wire is in physical contact with the exterior surface of the delivery tube and provides a voltage of about 1 V to about 12. The electrostatic applicator system of claim 11, providing a potential of 40 kV.

13. The delivery tube is assembled with the syringe and the nozzle housing. When the syringe receives air from the air supply port, the syringe receives fluid from the barrel portion. and configured to eject a fluid uniformly charged by the voltage wire. The electrostatic applicator system of claim 11.

14. The HV module outputs a positive high voltage and a negative high voltage depending on the orientation of the rotating diode. a plurality of said rotating diodes configured to generate both a high negative voltage and a low negative voltage; The electrostatic applicator system of claim 11.

15. The HV module includes a first positive high voltage multiplier system and a second negative high voltage multiplier system.

12. The electrostatic applicator system of claim 11, comprising a circuit board including a system.

16. The reusable electrostatic applicator comprises: one or more processors; A memory for storing instructions; Including, The instructions, when executed by the one or more processors, For electrostatic applicators, Receiving an activation signal; (a) the potential from the high voltage module to the delivery tube via the voltage wire; b) the position of the piston and the plunger of the disposable cartridge; and / or or (c) a pump that regulates air flow from the device housing to the air supply port. and outputting a control signal to a motor that controls the The electrostatic applicator system of claim 11 , further comprising:

17. The disposable cartridge may include a syringe and / or a disposable cartridge. Regarding one or more operating parameters of the contents stored in another fluid reservoir. a built-in memory containing information; The one or more processors of the reusable electrostatic applicator and communicating with the on-board memory to obtain information regarding the contents of the cartridge through a flow configured to control at least one of the amount, potential, and nozzle setting. Item 17. An electrostatic applicator system according to item 16.

18. in response to detecting movement of the electrostatic applicator system, the one or more processors an accelerometer configured to output a motion signal to the sensor; In response to the one or more processors receiving the motion signal, or a plurality of processors, the electrostatic applicator system being activated by a wake signal from the processor. On-screen display and Further equipped with 18. The electrostatic applicator of claim 17, wherein the activation signal is a user input to the display screen. system.

19. 1. A method of operating an electrostatic applicator system, comprising: A first disposable cartridge is inserted into a chamber housing of the electrostatic applicator system. Inserting and operating a motor via an actuation input to the electrostatic applicator system; and and causing an electrical potential to be delivered to a delivery tube of the first disposable cartridge. And Including, By said insertion, A voltage contact at a first end of a voltage wire in the first disposable cartridge is connected to the electrostatic adapter. contact the voltage contacts of the applicator system, A first end of an air delivery tube in the first disposable cartridge is connected to the electrostatic applicator. Fluidly connected to the air supply of the Cater system; a plunger of a syringe containing a first fluid within the first disposable cartridge; is aligned with a piston of the electrostatic applicator system.

20. The first disposable cartridge contains information regarding an operating parameter of the first fluid. Includes built-in memory, Inserting the first disposable cartridge into the chamber housing This causes the operating parameters to be sent to the memory of the electrostatic applicator system. 、 The operating parameters include the speed of the motor, the air and a voltage applied to the delivery tube.

20. The method of claim 19.

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