Agent delivery systems and methods of using the same

Abstract

To provide improved agent delivery systems and methods of using the same.SOLUTION: A medical device includes a handle for conveying an agent having particles, and a receiver having a first lumen defined by a first end and a second end. The receiver has an axis extending between the first end and the second end. The first end is configured to receive the particles from the handle, and the second end is in communication with a second lumen having a cross-sectional dimension smaller than a cross-sectional dimension of the first lumen. Each of the cross-sectional dimensions of the first lumen and the second lumen is measured transverse to the axis. The second end is configured to receive the particles from the first end of the receiver. The second lumen is configured to control delivery of the agent to a delivery conduit in fluid communication with the second lumen based on sizes of the particles.SELECTED DRAWING: Figure 3

Description

Technical Field

[0001] Various aspects of the present disclosure generally relate to drug delivery systems, devices, and related methods. In embodiments, the present disclosure relates to systems, devices, and related methods for delivering therapeutic agents to a target treatment site and the like.

Background Art

[0002] In certain medical procedures, it may be necessary to stop or minimize bleeding within the body. For example, endoscopic medical procedures may require hemostasis of bleeding tissue within the gastrointestinal tract, such as in the esophagus, stomach, or intestine.

[0003] During an endoscopic procedure, the user inserts the shaft of the endoscope into the body lumen of the patient. The user uses the handle of the endoscope to control the endoscope during the procedure. Instruments pass through the working channel of the endoscope, for example, via a port on the handle, to deliver treatment at the surgical site near the distal end of the endoscope. The surgical site is far from the operator.

[0004] To achieve hemostasis at a remote location, a hemostatic agent may be delivered. Delivery of the agent can be achieved, for example, by using a pressurized fluid system. However, such systems can make it difficult to control the delivery rate of the agent delivered to the target treatment site or the particle size of the agent. Accordingly, the desired delivery rate or size of the delivered agent may not be achieved, there may be no consistency in the amount of the agent, the agent may clog a portion of the delivery device, and / or the agent may not reach a treatment site deep within the GI tract.

Summary of the Invention

[0005] Aspects of the present disclosure relate, inter alia, to systems, devices, and methods for delivery of agents of various sizes and the like. Each aspect disclosed herein may include one or more of the described features related to some of the other disclosed aspects.

[0006] According to one example, a medical device may include a handle for carrying a medicament having particles, and a receiver having a first lumen defined by a first end and a second end. The receiver has an axis extending between the first end and the second end. The first end is configured to receive the particles from the handle, and the second end communicates with a second lumen having a cross-sectional dimension smaller than the cross-sectional dimension of the first lumen. The cross-sectional dimension of each of the first lumen and the second lumen is measured across the axis. The second end is configured to receive the particles from the first end of the receiver. The second lumen is configured to control delivery of the medicament to a delivery tube in communication with the second lumen based on the size of the particles.

[0007] Some of the medical devices described herein may include any of the following features. The handle includes an enclosure for storing the drug and a filter mechanism disposed within the enclosure, and the filter mechanism may be configured to suppress at least a portion of the drug from being conveyed to the receiver based on the particle size. The first end includes a third lumen having a cross-sectional dimension that, when measured across the axis, is smaller than the cross-sectional lumen of the first lumen and larger than the cross-sectional lumen of the second lumen. The first lumen is disposed between the second lumen and the third lumen, and the third lumen communicates with the second lumen through the first lumen. The second lumen is defined by and extends through the second end, and the third lumen is defined by and extends through the first end. The second end of the receiver includes an interface configured to control the delivery of the drug from the first lumen to the second lumen based on the particle size. The interface at the second end is a plane extending across the first lumen and defines an opening disposed along the plane communicating with the second lumen. The interface at the second end is a tapered surface defining an opening communicating with the second lumen. The length of the first lumen along its axis is longer than the lengths of each of the second lumen and the third lumen along their respective axes. The receiver is configured to mix the drug within the first lumen and separate the particles based on the size of the particles. The second end of the receiver is configured to receive any particles of the particles within the second lumen when the size of the particles is below a predetermined size. The medical device further includes a plunger at least partially disposed within the enclosure, and the plunger is configured to move relative to the enclosure to move the drug within the enclosure. The plunger is configured to deliver a pressurizing medium into the enclosure to move the drug toward the second end of the receiver.The medical device further includes a handle coupled to the plunger, the handle being configured to control movement of the plunger relative to the enclosure to control delivery of the agent from the enclosure to the receiver.

[0008] According to another example, a medical device may include an enclosure for storing an agent having particles, a delivery tube, and a receiver disposed between and in communication with the enclosure and the delivery tube. The receiver has a longitudinal axis. The receiver includes a first lumen having a first cross-sectional dimension and a second lumen having a second cross-sectional dimension smaller than the first cross-sectional dimension. Each of the cross-sectional dimensions of the first lumen and the second lumen is measured transverse to the longitudinal axis. The first lumen is configured to capture the particles of the agent having a first size received from the enclosure, and the second lumen is configured to deliver the particles of the agent having a second size to the delivery tube. The second size is smaller than the first size.

[0009] Any of the medical devices described herein may include any of the following features. The second lumen is configured to inhibit delivery of the particles of the agent having the first size to the delivery tube. The medical device further includes a ratchet configured to control the amount of the agent delivered from the enclosure to the receiver in response to actuation of the handle. The medical device further includes a plunger at least partially disposed within the enclosure, the plunger being movable relative to the enclosure, and the ratchet being configured to control movement of the plunger into the enclosure. The plunger includes a nozzle tip that moves a pressurizing medium toward the agent stored in the enclosure to deliver the particles to the receiver.

[0010] According to another embodiment, a method for delivering a drug via a medical device including an enclosure, a receiver, and a delivery tube may include delivering the drug stored within the enclosure into a first lumen of the receiver. The drug is delivered in response to the operation of a pressure source in communication with the enclosure. The method may include delivering particles of the drug having a size smaller than a predetermined size into a second lumen of the receiver and delivering the particles of the drug having the size smaller than the predetermined size from the second lumen into the delivery tube.

[0011] It should be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and do not limit the claimed invention.

Brief Description of the Drawings

[0012] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate exemplary aspects of the present disclosure and, together with the description, serve to explain the principles of the present disclosure.

[0013]

Figure 1

[0014]

Figure 2

[0015]

Figure 3

[0016]

Figure 4A

[0017]

Figure 4B

[0018]

Figure 5

[0019]

Figure 6A

[0020]

Figure 6B

[0021]

Figure 6C

[0022] Among other things, the present disclosure relates to systems, devices, and methods for endoscopic delivery, such as hemostatic agents. Aspects of the present disclosure will now be described in detail, examples of which are shown in the accompanying drawings. The same or similar reference numbers are used in the drawings so as to indicate the same or similar parts as much as possible. The term "distal" refers to the part that is farthest from the user when introducing the device into the patient. In contrast, the term "proximal" refers to the part that is closest to the user when placing the device within the patient. As used herein, the terms "comprises," "comprising," or any other variation thereof are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not necessarily include only those elements, but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. The term "exemplary" is used in the sense of "example" rather than "ideal." As used herein, the terms "about," "substantially," and "approximately" indicate a range of values within + / - 10% of a given numerical value.

[0023] Embodiments of the present disclosure can be used to deliver substances to a bleeding target treatment site so as to achieve hemostasis or delivery of a therapeutic agent. For example, a hemostatic agent in powder form can be delivered to treat gastrointestinal bleeding by a medical device that includes a receiver having a first lumen configured to receive powder particles. In some embodiments, the first lumen communicates with a second lumen having a cross-sectional dimension smaller than the cross-sectional dimension of the first lumen. In some embodiments, the second lumen is configured to control the delivery of the powder to a delivery tube that communicates with the second lumen based on the particle size. Embodiments of the present disclosure are not limited to such devices and methods, but instead can relate to devices and methods for performing various medical procedures and / or treating the large intestine (colon), small intestine, cecum, esophagus, any other part of the gastrointestinal tract, and / or any other suitable patient anatomical structure (collectively referred to herein as the "target treatment site"). The various embodiments described herein include single-use or disposable medical devices.

[0024] In one example, a medical system for delivering a hemostatic substance / hemostatic agent can include a receiver for receiving the agent and sending the agent to a catheter or other tube for delivery to a target treatment site within a subject. In embodiments, the receiver can allow delivery of the agent to the subject at a desired particle size and suppress delivery of the agent to the subject at an undesired particle size. The receiver can include a funnel having a configuration configured to facilitate movement of a portion of the agent at a desired particle size while retaining a portion of the agent within the receiver at an undesired particle size. The configuration of the funnel can include a flat surface, a concave surface, or a convex surface that intersects the flow of the agent. Next, the examples of the present disclosure described above are referred to in detail and are shown in the accompanying drawings. As far as possible, the same reference numbers are used throughout the drawings to indicate the same or similar parts.

[0025] FIG. 1 shows a side view of an exemplary medical device 100 according to an example of the present disclosure. The medical device 100 may include an insertion portion 102, a proximal portion 110, and a receiver 120. In some embodiments, the insertion portion 102 of the medical device 100 may include a catheter, an endoscope, a tube, etc. for delivering a substance to a target treatment site within a patient. The proximal portion 110 may have a body 111 defined by a distal end 112 and a proximal end 114, and the distal end 112 of the proximal portion 110 may have a port 116 for connecting one or more components of the medical device 100, such as the receiver 120, to the proximal portion 110.

[0026] The proximal end 114 of the proximal portion 110 may include, for example, a handle 118 sized and shaped to be manually graspable by a user of the proximal portion 110 during a procedure. It should be understood that the sizes, shapes, contours, and / or configurations of the insertion portion 102 and / or the proximal portion 110 shown and described herein are merely examples and may include various other suitable arrangements without departing from the scope of the present disclosure.

[0027] Referring further to FIG. 1, the proximal portion 110 of the medical device 100 may further include an enclosure 119 sized and shaped to store one or more components of the proximal portion 110 herein. In an embodiment, the enclosure 119 is disposed adjacent to the distal end 112 of the body 111, but it should be understood that the enclosure 119 may be disposed at various other positions along the body 111. Additionally and / or alternatively, in other embodiments, the enclosure 119 may be such that one or more components stored within the enclosure 119 may be disposed within the body 111. By way of example, the enclosure 119 of the proximal portion 110 may include a container (not shown) for storing one or more substances, such as a drug. The drug may include, for example, a therapeutic agent capable of coagulating blood, such as a hemostatic powder. In other embodiments, the drug may include various other materials and / or substances suitable for delivery.

[0028] As a further example, the body 111 of the proximal portion 110 may include a pressurized media source (not shown) that stores a pressurized media, such as a pressurized fluid. The pressurized fluid may include compressed air / compressed gas, such as carbon dioxide (CO2). The pressurized media source may include a compressed air system, such as a pressurized cylinder. As described in more detail herein, the pressurized media source may be configured to supply the pressurized media to a container within the enclosure 119 for mixing one or more substances (e.g., drugs) stored in the container and / or for dispensing the substances to one or more other components of the medical device 100. Examples of one or more components included in the proximal portion 110 of the medical device 100 may be in accordance with at least some teachings of U.S. Patent Application No. 62 / 957,519, entitled "Devices and Methods for Delivering Powdered Drugs," filed on January 6, 2020, the disclosure of which is incorporated herein by reference.

[0029] Referring to FIG. 1, the receiver 120 may be disposed at the distal end 112 of the proximal portion 110 and may be coupled to the body 111 via the port 116. In this case, the receiver 120 is in communication with one or more components of the proximal portion 110, such as the container of the enclosure 119 and / or the pressurized media source. The insertion portion 102 may be coupled to the receiver 120 at the opposite end of the port 116 and may communicate with one or more components of the proximal portion 110 via the receiver 120 disposed therebetween.

[0030] Referring to FIG. 2, an exemplary schematic diagram of the receiver 120A is shown. The receiver 120A may include a sheath 130 defined by a wall 137, a proximal end 133, and a distal end 134A. The wall 137 may be cylindrical or any other suitable shape. The sheath 130 defines a main lumen 132 that extends between the proximal end 133 and the distal end 134A. In the example, at least a portion of the proximal end 133 and the distal end 134A may be at least partially disposed within the main lumen 132 of the sheath 130. The receiver 120A further includes an inlet head 122 at the proximal end 133 of the sheath 130, and the inlet head 122 defines an opening 124. In the example, the inlet head 122 extends proximally with respect to the proximal end 133 of the receiver 120A, and the inlet head 122 is disposed outside the main lumen 132 of the sheath 130.

[0031] The receiver 120A may further include a knob 126 at the proximal end 133. In the example, the knob 126 may be disposed between the inlet head 122 and the proximal end 133. In some examples, the knob 126 may be integral with the inlet head 122, and the knob 126 and the inlet head 122 may form an integral structure, but in other examples, the knob 126 may be configured to be separated from the inlet head 122. The receiver 120A may further include one or more threads 128 disposed on the outer peripheral surface of the inlet head 122. In this case, the one or more threads 128 extend around the opening 124.

[0032] Referring to FIG. 2, the knob 126 may include one or more grippable features (e.g., recesses, protrusions, etc.) on the knob for manually operating the receiver 120A. When the knob 126 is fixed to the inlet head 122, the knob 126 may be configured to rotate the inlet head 122 in response to the actuation (e.g., rotation) of the knob 126 relative to one or more components of the medical device 110, such as the proximal portion 110. When the inlet head 122 is received within the port 116, it should be understood that the knob 126 may be connectable (and separable) to the receiver 120A to the proximal portion 110 of the medical device 100 by rotatably engaging (and disengaging) one or more threads 128 with corresponding threads (not shown) of the body 111. In an example, the inlet head 122 of the receiver 120A may include a male luer connector for connection to a corresponding female luer connector disposed in the port 116 of the proximal portion 110. In this case, with the inlet head 122 connected to the port 116, the opening 124 may be in communication with one or more components of the proximal portion 110, such as a container, and a pressurized media source, etc.

[0033] Referring to FIG. 3, the receiver 120A may be connected to the insertion portion 102 of the medical device 100 at the distal end 134A. The main lumen 132 of the sheath 130 may communicate with the proximal lumen 131 of the proximal end 133, the inlet lumen 135 of the inlet head 122, and the distal lumen 139 of the distal end 134A. In this case, with the inlet lumen 135 in communication with the main lumen 132 of the sheath 130 via the proximal lumen 131 of the proximal end 133, the opening 124 of the inlet head 122 may be in communication with the inlet lumen 135. The longitudinal length of the receiver 120A may define a longitudinal axis (not shown) extending between the proximal end 133 and the distal end 134A.

[0034] The proximal lumen 131 of the proximal end 133 may have a first cross-sectional dimension, the distal lumen 139 of the distal end 134A may have a second cross-sectional dimension, and the inlet lumen 135 of the inlet head 122 may have a third cross-sectional dimension. It should be understood that, in an example, the cross-sectional dimensions of the proximal lumen 131, the distal lumen 139, and the inlet lumen 135 may cross the longitudinal axis of the receiver 120A. In an example, the length along the longitudinal axis of the main lumen 132 is longer than the length along the longitudinal axis of each of the proximal lumen 131, the distal lumen 139, and / or the inlet lumen 135.

[0035] In an example, the first cross-sectional dimension of the proximal lumen 131 may be different from the second cross-sectional dimension of the distal lumen 139 and / or the third cross-sectional dimension of the inlet lumen 135. For example, the first cross-sectional dimension of the proximal lumen 131 may be relatively larger than the second cross-sectional dimension of the distal lumen 139 and / or the third cross-sectional dimension of the inlet lumen 135. Further, in some examples, the third cross-sectional dimension of the inlet lumen 135 may be relatively larger than the second cross-sectional dimension of the distal lumen 139.

[0036] As a further example, each of the first cross-sectional dimension of the proximal lumen 131, the second cross-sectional dimension of the distal lumen 139, and / or the third cross-sectional dimension of the inlet lumen 135 may be different from the cross-sectional dimension of the main lumen 132 of the sheath 130. In an example, the cross-sectional dimension of the main lumen 132 may be relatively larger than the first cross-sectional dimension of the proximal lumen 131, the second cross-sectional dimension of the distal lumen 139, and / or the third cross-sectional dimension of the inlet lumen 135, respectively. In some embodiments, the main lumen 132 may be in the range of about 0.4 inches (1.0 cm) to about 0.6 inches (1.5 cm), for example, may include a diameter of 0.5 inches (1.3 cm). Further, the main lumen 132 may, for example, be in the range of about 0.9 inches (2.3 cm) to about 1.1 inches (2.8 cm), for example, may include a longitudinal length of 1.0 inches (2.5 cm).

[0037] Referring further to FIG. 3, the lumen 104 of the insertion portion 102 can communicate with the main lumen 132 of the sheath 130 through the distal lumen 139 at the distal end 134A when the insertion portion 102 is connected to the receiver 120A at the distal end 134A. As described in more detail herein, the lumen 104 of the insertion portion 102 can include cross-sectional dimensions of a size and shape that can receive particles of a drug having a predetermined size stored in the container of the enclosure 119. For example, in embodiments where the particles of the drug can be approximately 325 μm to approximately 425 μm in size, the lumen 104 of the insertion portion 102 can be approximately 0.05 inches (0.13 cm) in diameter. As a further example, in embodiments where the particles of the drug can be approximately 500 μm to approximately 600 μm in size, the lumen 104 of the insertion portion 102 can be approximately 0.08 inches (0.20 cm) in diameter. In some examples, the second cross-sectional dimension of the distal lumen 139 can be at least less than or equal to the cross-sectional dimension of the lumen 104 of the insertion portion 102.

[0038] Referring to FIGS. 2 and 3, the distal end 134A of the receiver 120A can include an interface 136A and an opening 138A. In an example, the interface 136A can define the proximal surface of the distal end 134A that can be disposed within the main lumen 132 of the sheath 130. The opening 138A can be disposed along the interface 136A of the distal end 134A and can communicate with the distal lumen 139 of the distal end 134A. In an example, the interface 136A, the opening 138A, and / or the distal lumen 139 of the distal end 134A can include a size, shape, and / or structure configured to inhibit the delivery of one or more substances (or portions thereof) from the sheath 130 to one or more components of the medical device 100, such as the insertion portion 102. Additionally and / or alternatively, the interface 136A, the opening 138A, and / or the distal lumen 139 can include a size, shape, and / or structure configured to permit the delivery of one or more other substances (or portions thereof) from the sheath 130 to one or more other components of the medical device 100, such as the insertion portion 102.

[0039] In an example, the interface 136A at the distal end 134A can be a concave surface that extends distally away from the proximal end 133 of the receiver 120A. For example, the distal end 134A can have a concave, recessed, indented, funnel-shaped, and / or depressed structure that defines the interface 136A. In this case, when the opening 138A is disposed at the center of the interface 136A, the cross-sectional dimension (e.g., diameter) of the interface 136A adjacent to the opening 138A can be smaller than the cross-sectional dimension (e.g., diameter) of the interface 136A relatively far from the opening 138A. As a result, it should be understood that the interface 136A at the distal end 134A is relatively wider along the portion closer to the proximal end 133 than the opposing portion closer to the opening 138A and / or the insertion portion 102.

[0040] Referring further to FIGS. 2 and 3, the interface 136A at the distal end 134A can be configured to control the amount of material (e.g., drug) that can be received into the sheath 130 and delivered to the insertion portion 102 via the distal lumen 139 at the distal end 134A. In this case, the interface 136A can control the amount of material delivered based on the size of the drug-containing particles. The surface structure of the interface 136A can guide and / or move particles having a predetermined size from the main lumen 132 of the sheath 130 toward the opening 138A and into the lumen 104 of the insertion portion 102. Further, the surface structure of the interface 136A can suppress the delivery of drug particles having no predetermined size that are received into the sheath 130 and into the lumen 104 through the opening 138A.

[0041] The distal lumen 139 of the opening 138A and / or the distal end 134A can be further configured to control the amount of substance received by the sheath 130 and delivered to the insertion portion 102 based on the particle size of the drug. For example, the cross-sectional dimensions of the opening 138A and / or the distal lumen 139 can facilitate the delivery of particles having a predetermined size while suppressing the delivery of drug particles having a size that does not have a predetermined size from the main lumen 132 to the lumen 104 of the insertion portion 102. In an example, the predetermined size of the particles can include a predetermined relationship between the cross-sectional dimension of the particles and the cross-sectional dimension of the lumen 104 of the insertion portion 102. For example, the predetermined cross-sectional size of the particles can be approximately 1 / 3, 1 / 4, 1 / 5, 1 / 6, 1 / 8, 1 / 9, 1 / 10 or less of the cross-sectional dimension of the lumen 104 of the insertion portion 102, or can be smaller than the cross-sectional dimension of the lumen 104 of the insertion portion 102. In other examples, the predetermined size can include various other suitable cross-sectional dimensions with respect to the insertion portion 102.

[0042] According to an exemplary method of using the medical device 100, the substance may initially be stored in the container of the enclosure 119, and the receiver 120A can be communicated with the body 111 of the proximal portion 110 via the port 116. In this case, the inlet head 122 can be received in the port 116, and one or more threads 128 can engage corresponding threads at the port 116. The threads 128 can be engaged with the body 111 of the proximal portion 110 in response to the actuation (e.g., rotation) of the knob 126. Further, the insertion portion 102 can be communicated with the receiver 120A at the distal end 134A, and the lumen 104 of the insertion portion 102 can communicate with the container of the enclosure 119 via the proximal lumen 131, the main lumen 132, and the distal lumen 139.

[0043] In this case, when the pressurized medium source of the proximal portion 110 is activated, the pressurized medium can be sent to the container of the enclosure 119. The pressurized medium can move the substance stored in the container therein, thereby generating a mixture of substances. In the example, the substance can be a medicament (e.g., hemostatic powder) comprising a plurality of particles having various sizes and / or shapes. It should be understood that each of the plurality of particles can include spherical, irregular, and / or asymmetric contours and have different structures from each other. Activation of the pressurized medium source of the medical device 110 can cause a change in pressure within the container of the enclosure 119 that can move the medicament from the container to the receiver 120A via the port 116.

[0044] In the example, the particles of the medicament are delivered through the inlet head 122 into the proximal lumen 131 of the proximal end 133 and received within the main lumen 132 of the sheath 130. When a plurality of particles of the medicament are received within the sheath 130, the receiver 120A can provide a further mixture of the medicament within the main lumen 132. Entering the sheath 130 of the receiver 120A via the proximal end 133, the plurality of particles of the medicament can move within the main lumen 132 and toward the distal end 134A. In this case, the particles can encounter the interface 136A of the distal end 134A and, based on the size of the particles, can be received through the opening 138A or can move proximally (e.g., rearward) within the main lumen 132 back toward the proximal end 133. In other words, the receiver 120A of the medical device 100 can be configured to mix, separate, and / or classify the medicament within the sheath 130 based on the cross-sectional dimensions, size, and / or shape of the particles.

[0045] As an example, the interface 136A of the distal end 134A can be configured to inhibit the intrusion of one or more particles of the agent into the opening 138A and the distal end 139 when the particles have a size greater than a predetermined size. In the example, the predetermined size of the particles can be approximately 1 / 3, 1 / 4, 1 / 5, 1 / 6, 1 / 8, 1 / 9, 1 / 10 or less of the cross-sectional dimension of the lumen 104 of the insertion portion 102, or can include a predetermined cross-sectional dimension smaller than the cross-sectional dimension of the lumen 104 of the insertion portion 102. It should be understood that if the cross-sectional dimensions of the opening 138A and / or the distal lumen 139 are relatively smaller than the cross-sectional dimension of the proximal lumen 131, a portion of the particles received into the sheath 130 through the proximal end 133 can be delivered through the distal lumen 139. In this case, the remainder of the particles that do not have the predetermined size can be maintained within the main lumen 132 of the sheath 130.

[0046] By facilitating the delivery of a portion of the particles of the agent having a predetermined size through the opening 138A and the distal lumen 139, the receiver 120A can minimize clogging of the lumen 104 of the insertion portion 102 during the procedure. In this case, the interface 136A, the opening 138A, and / or the distal lumen 139 of the distal end 134A can reduce the delivery of oversized particles within the insertion portion 102 (e.g., individually and / or collectively), thereby reducing instances of clogging of the lumen 104 and / or damage to the subject (e.g., the patient). As a result, it should be understood that a predetermined portion of the substance stored in the container of the enclosure 119 (e.g., particles of the agent having a predetermined size) can be delivered to the target treatment site within the subject by the medical device 100 by the receiver 120A that is in communication between the insertion portion 102 and the proximal portion 110.

[0047] When the cross-sectional dimension of the proximal lumen 131 is relatively smaller than that of the main lumen 132, particles of the agent that are received by the sheath 130 and do not conform to a predetermined size limit can be maintained within the main lumen 132 between the proximal end 133 and the distal end 134, and / or can stagnate. In other words, a portion of the particles of the agent that do not have a predetermined size and that travel from the distal end 134A towards the proximal end 133 is suppressed from being delivered through the proximal end 133 by the flow of the inflow fluid that moves towards the main lumen 132 through the inlet lumen 135.

[0048] In some examples, at least a portion of the particles that do not conform to the predetermined size limit can be deposited along the bottom surface (or other surface) of the sheath 130. In this case, the particles deposited within the main lumen 132 of the sheath 130 can form a fixed and / or stationary layer of the substance within the receiver 120A. It should be understood that the cross-sectional dimension of the proximal lumen 131 of the proximal end 133 can be larger than all or substantially all of the particles received within the main lumen 132 of the sheath 130.

[0049] Referring to FIG. 4A, another exemplary receiver 120B is shown in accordance with an example of the present disclosure. Unless otherwise specified below, the receiver 120B can be substantially similar to the above-described receiver 120A, and like reference numerals are used to identify like components. It should be understood that the receiver 120B can be configured and operable in the same manner as the receiver 120A, and that the receiver 120B can be readily incorporated into the above-described medical device 100.

[0050] For example, the receiver 120B may include a distal end 134B disposed along an end opposite the proximal end 133 of the sheath 130. The distal end 134B can be at least partially disposed within the primary lumen 132 of the sheath 130 and may include an interface 136B and an opening 138B. The interface 136B defines a proximal face of the distal end 134B, and the opening 138B can be disposed along the interface 136B. The opening 138B can communicate with a distal lumen (similar to the distal lumen 139) of the distal end 134B. In an example, the interface 136B, the opening 138B, and / or the distal lumen of the distal end 134B can include a size (e.g., cross-sectional size), shape, and / or structure configured to inhibit delivery of one or more substances (or portions thereof) from the sheath 130 to the insertion portion 102. Additionally and / or alternatively, the interface 136B, the opening 138B, and / or the distal lumen of the distal end 134B can include a size (e.g., cross-sectional size), shape, and / or structure configured to permit delivery of one or more other substances (or portions thereof) from the sheath 130 to the insertion portion 102.

[0051] In an example, the interface 136B of the distal end 134B can have a protruding face that tapers proximally toward the proximal end 133 of the receiver 120B. In other words, the distal end 134B can be extended to define the interface 136B, have a conical shape, and / or have an expanded structure. In some examples, the interface 136B can be received within the sheath 130 via the distal lumen of the distal end 134B and configured to control the amount of a substance (e.g., a drug) delivered to the insertion portion 102. In this case, the interface 136B can control based on the size of particles containing the drug with respect to the amount of the substance being delivered. The structure of the interface 136B can guide and / or move particles of a predetermined size from the primary lumen 132 of the sheath 130 toward the opening 138B and into the lumen 104 of the insertion portion 102. Further, the structure of the interface 136B can inhibit delivery of drug particles received by the sheath 130 and not having a predetermined size from being received into the lumen 104 through the opening 138B.

[0052] Referring to FIG. 4B, another exemplary receiver 120C is shown in accordance with an example of the present disclosure. Unless otherwise specified below, the receiver 120C can be substantially similar to the above-described receiver 120A, and like reference numerals are used to identify like components. It should be understood that the receiver 120C can be configured and operable in the same manner as the receiver 120A, and that the receiver 120C can be readily incorporated within the medical device 100 described above.

[0053] For example, the receiver 120C can include a distal end 134C disposed along an end opposite the proximal end 133 of the sheath 130. The distal end 134C can be at least partially disposed within the main lumen 132 of the sheath 130 and can include an interface 136C and an opening 138C. The interface 136C defines a proximal surface of the distal end 134C, and the opening 138C can be disposed along the interface 136C. The opening 138C can communicate with a distal lumen (similar to distal lumen 139) of the distal end 134C. In the example, the interface 136C, the opening 138C, and / or the distal lumen of the distal end 134C can include a size (e.g., cross-sectional size), shape, and / or structure configured to inhibit delivery of one or more substances (or portions thereof) from the sheath 130 to the insertion portion 102. Additionally and / or alternatively, the interface 136C, the opening 138C, and / or the distal lumen of the distal end 134C can include a size (e.g., cross-sectional size), shape, and / or structure configured to permit delivery of one or more other substances (or portions thereof) from the sheath 130 to the insertion portion 102.

[0054] In an example, the interface 136C at the distal end 134C can be a plane extending across the longitudinal axis of the receiver 120C. For example, the distal end 134C can have a planar structure and / or a flat structure that defines the interface 136C. In some examples, the interface 136C can be configured to be received in the sheath 130 and control the amount of a substance (e.g., a drug) delivered to the insertion portion 102 through the distal lumen of the distal end 134C. In this case, the interface 136C can control the amount of the substance delivered based on the size of the particles including the drug. The structure of the interface 136C can guide and / or move particles having a predetermined size from the main lumen 132 of the sheath 130 toward the opening 138C and into the lumen 104 of the insertion portion 102. Further, the structure of the interface 136C can suppress the delivery of drug particles that are received in the sheath 130 and do not have a predetermined size from being received into the lumen 104 through the opening 138C.

[0055] FIG. 5 shows a side view of an exemplary medical device 200 according to an example of the present disclosure. The medical device 200 can include an insertion portion 102, a proximal portion 210, and a receiver 120. It should be understood that the medical device 200 can include any of the exemplary receivers 120A, 120B, 120C and the insertion portion 102 described above without departing from the scope of the present disclosure. The proximal portion 210 can have a first body 211 and a second body 216, the first body 211 being disposed at the distal end 212 of the proximal portion 210 and the second body 216 being disposed at the proximal end 214 of the proximal portion 210. The first body 211 of the proximal portion 210 can be connected to the second body 216 by a rod 217 extending therebetween. In an example, the rod 217 can be fixed to the second body 216 and can extend through the first body 211. As described in more detail herein, the second body 216 and the rod 217 can be configured to move relative to the first body 211 in response to the actuation of one or more other components of the medical device 200, such as one or more handles 218.

[0056] The proximal portion 210 of the medical device 200 may further include a switch 220, a plunger 230, and a syringe 240. The switch 220 of the proximal portion 210 may be in communication with a pressurized media source (not shown) by one or more tubes 222 connected to the switch 220 and the pressurized media source, respectively. Further, the switch 220 of the proximal portion 210 may be in communication with the plunger 230 by one or more tubes 222 connected thereto. As further described herein, the switch 220 is configured to selectively establish communication between the pressurized media source and the plunger 230 in response to actuation of the switch 220.

[0057] Referring further to FIG. 5, the plunger 230 of the proximal portion 210 may be defined by a distal end 232 and a proximal end 234 and may include a longitudinal length extending therebetween. It should be understood that the plunger 230 may define an inner lumen between the distal end 232 and the proximal end 234 and is configured to receive a pressurized media from a pressurized media source. The proximal end 234 of the plunger 230 may include a port 235 that may be configured and operable to communicate the plunger 230 with at least one of the one or more tubes 222. In this case, the plunger 230 is in communication with the switch 220 via a tube 222 received at the port 235. In other examples, it should be understood that the port 235 may be disposed along various other portions of the plunger 230 without departing from the scope of the present disclosure.

[0058] The proximal end 234 of the plunger 230 can be received within the slot 215 of the second body 216, thereby removably securing the plunger 230 to the second body 216. As will be described in more detail herein, with the proximal end 234 of the plunger 230 connected to the second body 216 via the slot 215, the plunger 230 is configured to move relative to the first body 211 in response to movement of the second body 216 relative to the first body 211. The syringe 240 of the proximal portion 210 is defined by a distal port 242 and a proximal flange 244 and may include a longitudinal length extending therebetween. The syringe 240 can define a lumen 246 between the distal port 242 and the proximal flange 244, within which a substance such as, for example, a medicament (e.g., a hemostatic powder) is stored and configured to receive the plunger 230.

[0059] In some embodiments, the syringe 240 can include one or more filter mechanisms 248 disposed within the lumen 246 at various suitable locations, for example, between the distal port 242 and the proximal flange 244. FIG. 5 shows one such filter mechanism 248. The filter mechanism 248 can include a mesh or screen having a porous structure. The pores of the filter mechanism 248 can be sized and / or shaped to at least partially inhibit a portion of the substance (e.g., microparticles of the hemostatic powder) from passing through the filter mechanism 248 (e.g., in a distal direction from a portion of the lumen 246 adjacent the proximal flange 244 to a portion of the lumen 246 adjacent the distal port 242). In other words, the filter mechanism 248 can be configured to allow a portion of the substance disposed within the lumen 246 to pass through the filter mechanism 248 (towards the distal port 242) based on the size of the particles of the substance being smaller than the dimensions of the pores (e.g., openings) of the filter mechanism 248. By retaining portions of the substance within the lumen 246 that are larger than the pores of the filter mechanism 248, the filter mechanism 248 can reduce instances of substances clogging one or more components of the medical device 200 (e.g., the distal port 242, the receiver 120, the insertion portion 102).

[0060] Referring further to FIG. 5, the proximal flange 244 of the syringe 240 may be configured and operable to removably engage with the slot 213 of the first body 211, thereby fixing the syringe 240 to the first body 211 of the proximal portion 210. In some examples, the first body 211 may further include one or more retaining mechanisms 219 along the outside of the first body 211 to fix the syringe 240 thereon. In other examples, it should be understood that the slot 213 and / or one or more retaining mechanisms 219 may be arranged along various other portions of the first body 211 differently from the description herein without departing from the scope of the present disclosure. The distal end 232 of the plunger 230 can be disposed within the lumen 246 of the syringe 240 and can be movable relative to the distal port 242. The distal end 232 of the plunger 230 may provide a seal against the inner surface of the wall of the syringe 246.

[0061] As described in more detail herein, the plunger 230 is configured to move relative to the syringe 240 within the lumen 246 in response to the movement of the second body 216 relative to the first body 211. In an example, the distal port 242 of the syringe 240 may be configured and operable to connect the syringe 240 to one or more components of the medical device 200, such as the receiver 120. In this case, the inlet head 122 of the receiver 120 can be received and fixed within the distal port 242 of the syringe 240, whereby the sheath 130 of the receiver 120 communicates with the lumen 246 of the syringe 240.

[0062] The first body 211 of the proximal portion 210 may further include one or more handles 218A, 218B. The handle 218A may be movably and configured to pivot with respect to the remainder of the first body 211 including the handle 218B. In an example, the handles 218A, 218B of the first body 211 may be coupled to a ratchet mechanism (not shown) of the proximal portion 210. For example, the ratchet mechanism may be disposed within the first body 211 and may be configured to control the speed of movement of the second body 216 with respect to the first body 211. When the handles 218A, 218B are pulled proximally, the ratchet mechanism is engaged to move the second body 216 with respect to the first body 211.

[0063] Referring to FIG. 5, with the plunger 230 fixed to the second body 216 and the syringe 240 fixed to the first body 211, the ratchet mechanism of the proximal portion 210 may further control the movement of the plunger 230 into the lumen 246 of the syringe 240 in response to the actuation of the handles 218A, 218B. The ratchet mechanism may be operable to facilitate the progressive driving of the second body 216 and the plunger 230 along respective plural incremental states with respect to the first body 211 and the syringe 240 in response to the mechanical actuation of the handles 218A, handle 218B. As described in further detail herein, the ratchet mechanism of the proximal portion 210 may be configured to control the delivery flow rate of the substance disposed within the lumen 246 of the syringe 240 by controlling the advancement of the plunger 230 with respect to the syringe 240.

[0064] FIGS. 6A through 6C show partial perspective views of the distal ends 234 of exemplary plungers 230A, 230B, 230C in accordance with an example of the present disclosure. Unless otherwise specified below, the plungers 230A, 230B, 230C are substantially similar to the plunger 230 described above, and like reference numerals are used to identify like components. It should be understood that the plungers 230A, 230B, 230C may be configured and operable like the plunger 230 and that the plungers 230A, 230B, 230C may be readily incorporated within the medical device 200 described above.

[0065] For example, first referring to FIG. 6A, an exemplary plunger 230A can include a rounded head 236 at its distal end 232, and the rounded head 236 forms a non-planar surface that can extend outwardly from the distal end 232. In some examples, the rounded head 236 includes a spherical, bulbous, and / or curved structure that forms a profile transverse to the longitudinal axis of the plunger 230A. As described in more detail herein, the rounded head 236 of the plunger 230A can be configured to move and / or guide one or more substances disposed within the lumen 246 of the syringe 240 toward the distal port 242 as the plunger 230A progresses therethrough.

[0066] The distal head 232 of the plunger 230A can further include an opening 239A disposed on the rounded head 236. In an example, the opening 239A is disposed along a central portion of the rounded head 236 and can communicate with the inner lumen of the plunger 230A. It should be understood that in other examples, the opening 239A can be disposed along various other portions of the rounded head 236. The opening 239A of the rounded head 236 can be sized and shaped to deliver a substance (e.g., a pressurizing medium) disposed within the inner lumen of the plunger 230A outwardly from the distal end 232, for example, into the syringe 240 when the plunger 230A is received within the lumen 246 thereof, and can be configured to deliver the substance.

[0067] Referring to FIG. 6B, an exemplary plunger 230B can include a rounded nozzle 238B that extends outwardly from a rounded head 236 at the distal end 232. In this case, the rounded nozzle 238B extends distally with respect to the rounded head 236 and includes a longitudinal length that is aligned parallel to the longitudinal axis of the plunger 230B. The distal head 232 of the plunger 230B further includes an opening 239B defined by the distal end of the rounded nozzle 238B. In the example, the opening 239B is disposed at the end of the rounded nozzle 238B and can communicate with the inner lumen of the plunger 230B. In other examples, it should be understood that the opening 239B can be disposed along various other portions of the rounded nozzle 238B and / or the rounded head 236.

[0068] The opening 239B of the rounded head 238B can be sized and shaped to deliver a substance disposed within the inner lumen of the plunger 230B outwardly from the distal end 232, for example, into the lumen 246 of the syringe 240 when the plunger 230B is received within the lumen 246 of the syringe 240, and can be configured to deliver. The rounded nozzle 238B can be sized and shaped to control the flow rate of the substance delivered from the opening 239B into the lumen 246 of the syringe 240, and can be configured to control. Further, the structure of the rounded nozzle 238B can be operable to facilitate the movement and / or guiding of the substance stored within the lumen 246 of the syringe 240 toward the distal port 232 while minimizing the compression of the substance within the lumen 246 by the rounded head 236.

[0069] Referring further to FIG. 6B, with the rounded nozzle 238B having a contour that extends relative to the distal end 232 of the plunger 230B, the plunger 230B can enable the delivery of a pressurizing medium to the agent within the syringe 240 while reducing the range of movement into the lumen 246 of the distal end 232 and movement toward the distal port 232 (e.g., translational movement). As a result, in response to the rounded head 236 of the plunger 230B that compresses the substance by its movement relative to the syringe 240, it should be understood that the rounded nozzle 238B can be configured to reduce the compression of the substance within the lumen 246 and the clogging of the distal port 242.

[0070] Next, referring to FIG. 6C, an exemplary plunger 230C can include a flat nozzle 238C that extends outwardly from the rounded head 236 of the distal end 232. In this case, the flat nozzle 238C extends distally from the rounded head 236 and includes a longitudinal length that is aligned parallel to the longitudinal axis of the plunger 230C. The distal head 232 of the plunger 230C can further include an opening 239C defined by the distal end of the flat nozzle 238C. In this example, the opening 239C is disposed at the end of the flat nozzle 238C and can communicate with the inner lumen of the plunger 230C. In other examples, it should be understood that the opening 239C can be disposed along various other portions of the flat nozzle 238C and / or the rounded head 236.

[0071] The opening 239C of the flat nozzle 238C is sized and shaped to deliver the material disposed within the inner lumen of the plunger 230C from the distal end 232 to the outside, and can be configured to deliver. The flat nozzle 238C may be sized and shaped to control the flow rate of the material delivered from the opening 239C, and can be configured to control. Further, the extended profile and / or structure of the flat nozzle 238C can be operable to facilitate the movement and / or guidance of the material stored in the syringe 240 toward the distal port 232 while minimizing the compression of the material within the lumen 246 by the rounded head 236. As a result, it should be understood that the flat nozzle 238C can be configured to reduce the compression of the material within the lumen 246 and the clogging of the distal port 242 in response to the rounded head 236 compressing the material by the movement of the plunger 230C relative to the syringe 240.

[0072] According to an exemplary method of use of the medical device 200, the material can first be stored within the lumen 246 of the syringe 240, and at least the distal end 232 of the plunger 230 can be disposed within the lumen 246. It should be understood that the medical device 200 can include any of the exemplary plungers 230A, 230B, 230C described above without departing from the scope of the present disclosure. The syringe 240 can be fixed to the first body 211 by disposing the proximal flange 244 within the slot 213 and engaging the syringe 240 with one or more retaining mechanisms 219. The plunger 230 can be fixed to the second body 216 by disposing the proximal end 234 within the slot 215 with the second body 216 moved to the most proximal (e.g., left side) extent relative to the first body 211. The switch 220 of the proximal portion 210 can be in communication with the port 235 of the plunger 230 via the tube 222.

[0073] The switch 220 can be further connected to a pressurized media source (not shown) via another tube 222, and the inner lumen of the plunger 230 communicates with the pressurized media source via the switch 220. The receiver 120 can be communicated with the syringe 240 via the distal port 242 by inserting the inlet head 122 into the distal port 242, and the thread 128 can be rotatably engaged with the corresponding thread at the distal port 242 by operating the knob 126. Further, the insertion portion 102 can be communicated with the receiver 120 at the distal end 134, and the inner lumen 104 of the insertion portion 102 can communicate with the inner lumen 246 of the syringe 240 via the receiver 120.

[0074] In this case, when the switch 220 is actuated, the pressurized media from the pressurized media source can be delivered to the plunger 230 and outward from the distal end 232. The pressurized media may move the substance stored in the inner lumen 246 therein, thereby producing a mixture of substances. In the example, the substance can be a medicament (e.g., hemostatic powder) containing a plurality of particles of various sizes and / or shapes. Actuation of the switch 220 of the medical device 200 can create a pressure change within the inner lumen 246 of the syringe 240 that can move the medicament from the inner lumen 246 to the receiver 120 via the distal port 242.

[0075] In the example, the particles of the medicament are delivered through the inlet head 122 and received within the sheath 130 of the receiver 120. When a plurality of particles of the medicament are received within the sheath 130, the receiver 120 can provide a further mixture of the medicament therein. The plurality of particles of the medicament can move within the sheath 130 and can be delivered through the distal end 134 to the insertion portion 102 according to the method described above. As a result, it should be understood that the receiver 120 can be configured to inhibit the entry of one or more particles of the medicament into the insertion portion 102 when the particles have a size larger than a predetermined size. In this case, the remainder of the particles that do not have the predetermined size can be retained within the sheath 130 of the receiver 120.

[0076] The actuation of handles 218A and 218B can provide for the advancement control of plunger 230 relative to syringe 240, for example, an advancement towards distal port 242 of distal end 232. In this case, the movement of distal end 232 relative to lumen 246 can move the drug stored in syringe 240 towards distal port 242 in response to rounded head 236 that abuts the drug and biases the drug distally. It should be understood that the rounded head 236 of distal end 232 can be configured to disrupt the deposited material disposed within lumen 246 of syringe 240 to facilitate the delivery of particles through distal port 242.

[0077] The movement control of plunger 230 relative to syringe 240 provided by the ratchet mechanism of proximal portion 210 can allow rounded head 236 to agitate the drug within syringe 240 by disturbing the arrangement and / or state of the particles stored along the bottom (or other surface) of lumen 246. It should be understood that the movement of the drug particles can be improved for delivery by a pressurizing medium through distal port 242 in response to rounded head 236 of plunger 230 that moves the particles.

[0078] In some examples, the movement of plunger 230 towards distal port 242 reduces the space between distal end 232 and distal port 242 within the syringe, thereby allowing the drug (disposed along the bottom of lumen 246) to accumulate relatively upward. In this case, the upper surface of the accumulated drug can rise (e.g., increase) as the space between distal end 232 and distal port 242 narrows, thereby adjusting the level (e.g., height) of the upper surface of the drug using openings 239A, 239B, 239C of plunger 230. As a result, the movement of plunger 230 relative to syringe 240 can facilitate guiding a pressurizing medium from openings 239A, 239B, 239C to the drug for delivery into receiver 120 by disposing the drug particles in the flow paths of openings 239A, 239B, 239C.

[0079] With the switch 220 actuated to allow delivery of the pressurizing medium within the plunger 230, the apertures 239A, 239B, 239C at the distal end 232 can deliver the pressurizing medium through those apertures and guide the particles of the medicament to the distal port 242. Further, in the examples of the plungers 230B, 230C each including a nozzle 238B, 238C, the extensions of the nozzles 238B, 238C can facilitate delivery of the pressurizing medium to the medicament while minimizing compression of the medicament by the abutment head 236 within the lumen 246, so that less movement of the plungers 230B, 230C is required.

[0080] In some examples, it should be understood that at least a portion of the medicament stored in the syringe 240 may remain within the lumen 246 to minimize clogging of the insertion portion 102 and may not need to be received by the receiver 120. Further, a portion of the medicament received within the receiver 120 may be disposed along the bottom surface of the sheath 130, thereby forming its upper surface. In this case, the pressurizing medium delivered from the plunger 230 into the receiver 120 can agitate the particles disposed along the upper surface of the medicament for delivery into the insertion portion 102.

[0081] Each of the above-described devices, assemblies, and methods can be used, for example, to provide delivery control of a hemostatic agent to a targeted treatment site. Any of the medical devices 100, 200 can be inserted, for example, using an imaging system, a lighting system, etc. that are useful for placing the medical devices 100, 200 within an endoscope or similar device, where the receivers 120A, 120B, 120C of the medical devices 100, 200 described above are located. By providing a device that allows a user to treat a subject's bleeding tissue using the receivers 120A, 120B, 120C to control the delivery rate of the hemostatic agent during surgery while minimizing clogging incidents, the user can reduce the overall time of the surgery, increase the efficiency and effectiveness of the surgery, and avoid unnecessary damage to the subject's body by devices that are ineffective in clogging and / or blood coagulation of the medical devices 100, 200.

[0082] It will be apparent to those skilled in the art that various modifications and alterations can be made to the devices and methods of the present disclosure without departing from the scope of the present disclosure. Other aspects of the present disclosure will be apparent to those skilled in the art by considering the present specification and by practicing the features disclosed herein. The present specification and examples are intended to be considered as merely exemplary.

Claims

1. 1. A medical device comprising: a receiver configured to receive a plurality of particles of a variety of sizes of the medicament, the receiver comprising: a main lumen having a cross-sectional dimension; a proximal lumen having a first cross-sectional dimension smaller than the cross-sectional dimension of the main lumen; a distal lumen having a second cross-sectional dimension smaller than the cross-sectional dimension of the main lumen; the proximal lumen is configured to receive all of the plurality of drug particles of various sizes received by the receiver, and the main lumen is configured to receive all of the plurality of drug particles of various sizes from the proximal lumen; A medical device, wherein the distal lumen is configured to inhibit a portion of the particles of the plurality of drugs of various sizes from exiting the main lumen based on a predetermined particle size, thereby maintaining a portion of the particles of the plurality of drugs having a size greater than the predetermined particle size within the main lumen.

2. the main lumen is disposed between the proximal lumen and the distal lumen such that the proximal lumen is in fluid communication with the distal lumen via the main lumen; The medical device of claim 1 , wherein the second cross-sectional dimension is smaller than the cross-sectional dimension of the main lumen.

3. 2. The medical device of claim 1, wherein the distal lumen includes an interface disposed adjacent to the main lumen, the interface configured to control delivery of the particles of the multiple agents from the main lumen to an insert fluidly coupled to the receiver based on size of the particles of the multiple agents.

4. The medical device of claim 3 , wherein the interface includes an opening in fluid communication with a lumen of the insert, the opening including a diameter corresponding to the second cross-sectional dimension.

5. The medical device of claim 4 , wherein the interface defines a tapered surface extending radially inward toward the opening.

6. The medical device of claim 1 , wherein the receiver is configured to mix particles of the plurality of agents in the main lumen with a pressurized medium.

7. The medical device of claim 1 , wherein the receiver is configured to separate particles of the plurality of agents of different sizes based on the size of the particles of the plurality of agents.

8. 10. The medical device of claim 1, further comprising a handle including a housing for storing the medication, the handle fluidly coupled to the receiver such that the housing is in fluid communication with the main lumen via the proximal lumen.

9. 10. The medical device of claim 8, further comprising a filter mechanism disposed within the housing, the filter mechanism configured to inhibit a second portion of the plurality of drug particles of varying sizes from exiting the handle and being received by the receiver based on a size of each of the plurality of drug particles.

10. 10. The medical device of claim 8, further comprising a plunger movably disposed within the housing, the plunger configured to translate relative to the housing to urge particles of the plurality of drugs from the housing towards the receiver.

11. The medical device of claim 10 , wherein the plunger is configured to urge a pressurized medium disposed within the housing along with the plurality of particles of the drug toward the receiver.

12. The medical device of claim 10 , wherein the handle is configured to translate the plunger relative to the housing in response to actuation.

13. 1. A medical device comprising: a receiver configured to receive a plurality of particles of a variety of sizes of the medicament, the receiver comprising: a main lumen having a cross-sectional dimension; a proximal lumen having a first cross-sectional dimension proximal to and parallel to the main lumen; a distal lumen having a second cross-sectional dimension, the distal lumen being distal to and parallel to the main lumen; A medical device, wherein the proximal lumen is configured to deliver all of the multiple drug particles of various sizes received within the receiver through the main lumen toward the distal lumen, the distal lumen is configured to deliver a portion of the multiple drug particles having a size smaller than a predetermined particle size, and the main lumen is configured to retain the remainder of the multiple drug particles based on the size of the remainder of the multiple drug particles being larger than the predetermined particle size.

14. 14. The medical device of claim 13, wherein the second cross-sectional dimension of the distal lumen is smaller than each of the cross-sectional dimension of the main lumen and the first cross-sectional dimension of the proximal lumen.

15. 14. The medical device of claim 13, wherein the receiver is configured to retain the remainder of the particles of the plurality of drugs within the main lumen between the proximal and distal lumens when the portion of the particles of the plurality of drugs is pushed through the main lumen into the distal lumen for delivery from the receiver.

16. 14. The medical device of claim 13, wherein the distal lumen is configured to inhibit delivery of the remainder of the particles of the plurality of agents having a size greater than a predetermined particle size.

17. 14. The medical device of claim 13, wherein the receiver is configured to deposit the remainder of the plurality of drug particles having a size larger than the predetermined particle size along a bottom surface of the main lumen to form a stationary layer within the main lumen.

18. The medical device of claim 13 , wherein each of the main lumen, the proximal lumen, and the distal lumen are coaxially aligned with one another.

19. 1. A medical device comprising: A drug comprising a plurality of particles of various sizes; a receiver including a main lumen, a proximal lumen disposed proximally from the main lumen, and a distal lumen disposed distally from the main lumen, the main lumen having a larger cross-sectional dimension than the proximal and distal lumens; A medical device, wherein the main lumen is configured to accept all of the plurality of particles of various sizes from the proximal lumen, and the distal lumen is configured to accept from the main lumen a first portion of the plurality of particles having a size smaller than a predetermined particle size and inhibit acceptance of a second portion of the plurality of particles having a size larger than the predetermined particle size.

20. 20. The medical device of claim 19, wherein the distal lumen is configured to redirect the second portion of the plurality of particles back toward the main lumen such that the main lumen is configured to collect the second portion of the plurality of particles.

Images