Management device, management system, and program

Abstract

To provide a management device that, in the case where a part of or all of devices of a cell culture system is stopped, can allow a user to easily recognize lapse time from a point when the devices are stopped.SOLUTION: A management device of a cell culture system has: an incubator which forms a culture area for culturing cells by a workpiece; a clean bench which forms a liquid operation area for performing a dispensation operation to the workpiece; and a stocker which stores the workpiece used on the clean bench, and comprises: an instruction part which receives a stop operation of a user, and outputs a stop instruction of stopping any one or all devices of the incubator, the clean bench and the stocker to a PLC (Programmable Logic Controller) controlling the cell culture system; and an alarm part which displays lapse time from a point when the devices are stopped.SELECTED DRAWING: Figure 3

Description

Technical Field

[0001] The present disclosure relates to a management device, a management system, and a program.

Background Art

[0002] In a cell culture system, it is important to manage the work processes for each project. For example, Patent Document 1 describes a technique for preventing schedule duplication in sample observation in an incubator.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] For example, when an abnormality such as a malfunction of the equipment or contamination occurs in a cell culture system, the user may stop the cell culture system. For example, if the abnormal stop of the incubator continues for a long time, the environment such as temperature and carbon dioxide concentration may not be properly maintained, and there is a possibility that the cells in culture may die. Therefore, it is very important for the user who needs to deal with such an abnormality to grasp the elapsed time since the equipment was stopped.

[0005] An object of the present disclosure is to provide a management device, a management system, and a program that can easily make a user recognize the elapsed time since a part or all of the equipment of a cell culture system was stopped.

Means for Solving the Problems

[0006] According to one aspect of the present disclosure, a management device is a management device of a cell culture system having an incubator that forms a culture area for culturing cells on a workpiece, a clean bench that forms a liquid operation area for performing a dispensing operation on the workpiece, and a stocker that stores the workpiece used in the clean bench, and includes an instruction unit that receives a stop operation of a user and outputs a stop instruction to stop any one or all of the incubator, the clean bench, and the stocker to a PLC (Programmable Logic Controller) that controls the cell culture system, and a warning unit that displays the elapsed time since the device was stopped.

[0007] According to one aspect of the present disclosure, a management method is a management method of a cell culture system having an incubator that forms a culture area for culturing cells on a workpiece, a clean bench that forms a liquid operation area for performing a dispensing operation on the workpiece, and a stocker that stores the workpiece used in the clean bench, and includes a step of receiving a stop operation of a user and outputting a stop instruction to stop any one or all of the incubator, the clean bench, and the stocker to a PLC (Programmable Logic Controller) that controls the cell culture system, and a step of displaying the elapsed time since the device was stopped.

[0008] According to one aspect of the present disclosure, a program causes a management device of a cell culture system having an incubator that forms a culture area for culturing cells on a workpiece, a clean bench that forms a liquid operation area for performing a dispensing operation on the workpiece, and a stocker that stores the workpiece used in the clean bench to execute a step of receiving a stop operation of a user and outputting a stop instruction to stop any one or all of the incubator, the clean bench, and the stocker to a PLC (Programmable Logic Controller) that controls the cell culture system, and a step of displaying the elapsed time since the device was stopped.

Effect of the Invention

[0009] According to the above aspect, when some or all of the devices of the cell culture system are stopped, the elapsed time since the stop can be easily recognized by the user.

Brief Description of the Drawings

[0010]

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

Figure 11

Modes for Carrying Out the Invention

[0011] <First Embodiment> Hereinafter, a first embodiment of the present disclosure will be described in detail with reference to FIGS. 1 to 11.

[0012] As shown in FIG. 1, the cell culture system 100 of this embodiment is a system that performs cell culture and analysis of cells after culture in an unmanned and automatic manner, with the work W as the processing unit.

[0013] (Configuration of Cell Culture System) As shown in FIG. 1, the cell culture system 100 includes a stocker 110, a cell storage booth 120, an incubator 130, a clean bench 140, a pass box 150, a measuring device 160, a medium supply device 161, and a waste liquid tank 162.

[0014] <Stocker> The stocker 110 is a facility for storing a plurality of works W used in the incubator 130 and the clean bench 140. The work W has a flask for storing a culture solution inside. The stocker 110 forms a work storage area R1 inside. In the work storage area R1 of the stocker 110, a work storage device 112 is arranged. The work storage device 112 can store a plurality of works W. In addition, the stocker 110 is provided with a door 110a for carrying out the work W to the clean bench 140 by a conveying device (not shown).

[0015] <Cell Storage Booth> The cell storage booth 120 is a facility for storing cultured cells. The cell storage booth 120 forms a cell storage area R2 inside. In the cell storage area R2 of the cell storage booth 120, a storage container 122 for cryopreserving a part of the cultured solution in which cell growth has progressed is arranged. In addition, the cell storage booth 120 is provided with a door 120a for carrying in and out the work W between the clean bench 140 by a conveying device (not shown).

[0016] <Incubator> The incubator 130 is equipment for growing cells in a culture solution. The incubator 130 forms a culture area R3 that is controlled at a temperature, humidity, and carbon dioxide concentration suitable for cell culture. In the culture area R3 of the incubator 130, for example, a plurality of shaking stages 132 are provided, and a plurality of workpieces W can be shaken. The incubator 130 has a transport device (not shown) for automatically transporting the workpiece W within the culture area R3.

[0017] <Clean bench> The clean bench 140 performs various operations and processes on the workpiece W, such as dispensing operations, waste liquid extraction, and labeling. Inside the clean bench 140, a liquid operation area R4, which is a highly clean and aseptic space, is formed. In the liquid operation area R4 of the clean bench 140, a plurality (three in the example of FIG. 1) of dispensing devices 142 are arranged. The dispensing device 142 performs dispensing operations on the workpiece W. Also, the clean bench 140 has a transport device (not shown) for automatically transporting the workpiece W within the liquid operation area R4.

[0018] <Pass box> The pass box 150 is provided between the incubator 130 and the clean bench 140. The workpiece W is transferred between the culture area R3 and the liquid operation area R4 through this pass box 150. The pass box 150 has a first door 150a and a second door 150b. The first door 150a switches the communication state and non-blocking state between the space inside the pass box 150 and the culture area R3. The second door 150b switches the communication state and non-communication state between the space inside the pass box 150 and the liquid operation area R4. The first door 150a and the second door 150b are not simultaneously in the open state, and thus the culture area R3 and the liquid operation area R4 do not directly communicate.

[0019] <Measuring device> The measuring device 160 is arranged adjacent to the clean bench 140. The measuring device 160 is a device capable of measuring and analyzing the number of cells in the culture solution dispensed from the dispensing device 142.

[0020] <Medium supply device> The medium supply device 161 is arranged adjacent to the clean bench 140. The medium supply device 161 is a device capable of supplying the medium to be accommodated in the work W (flask) via the dispensing device 142.

[0021] <Waste liquid tank> The waste liquid tank 162 is arranged adjacent to the clean bench 140. The waste liquid tank 162 is transferred with the waste liquid from a waste liquid extraction device (not shown) arranged in the clean bench 140.

[0022] (Operation of cell culture system) In the cell culture system 100 configured as described above, cell growth is promoted by shaking the culture solution in the work W on the shaking stage 132 of the incubator 130. The work W in which cell growth has progressed is transferred to the liquid operation area R4 via the pass box 150. The culture solution in the work W transferred to the liquid operation area R4 is dispensed, or the medium is supplied to the work W.

[0023] On the other hand, when cell growth is performed using a new work W, for example, it is performed in the following procedure. First, the transfer device in the stocker 110 takes out a new work W from the work storage device 112 and transfers it into the liquid operation area R4. In the liquid operation area R4, the medium is supplied to the new work W that does not contain the culture solution, and the culture solution is dispensed from the work W transferred from the liquid operation area R4 containing the grown culture solution in which cell growth has progressed, into the new work W. Thereby, the operation of transplanting (subculturing) cells to the new work W is completed. The new work W that has undergone the subculturing operation is transferred to the incubator 130, cell growth is performed, and the above processing is repeated. Also, during the subculturing operation, a part of the culture solution is dispensed into the work W for cryopreservation as needed, transferred to the cell storage booth 120, and cryopreserved.

[0024] (Configuration of the management system) The management system 200 is a system that performs control, monitoring, creation of a culture schedule necessary for control, etc. of the cell culture system 100. As shown in FIG. 2, the management system 200 includes a PLC (Programmable Logic Controller) 20 and a management device 30.

[0025] <plc> The PLC 20 automatically controls the operations of each device in the cell culture system 100 according to the culture schedule for each project (for each cell requested by the customer). Also, the PLC 20 stops or starts (resumes) any one or all of the devices among the stocker 110, the incubator 130, and the clean bench 140 according to the operation instructions from the management device 30.

[0026] <Management device> The management device 30 is communicably connected to the PLC 20. Based on the information acquired from the PLC 20, the information input by the user, etc., the management device 30 manages the work process (culture schedule) of the project operating in the cell culture system 100, monitors and displays the state of the project (the position in the work process, the working state if it is in operation, etc.) and the presence or absence of abnormalities in the cell culture system 100. Here, the abnormalities include system - side abnormalities such as malfunction of the cell culture system 100 and control errors, and cell - side abnormalities such as contamination.

[0027] (Functional configuration of the management device) As shown in FIG. 3, the management device 30 includes a processor 31, a memory 32, a storage 33, a communication interface 34, a display unit 35, and an input unit 36.

[0028] By operating according to a predetermined program, the processor 31 functions as an acquisition unit 311, an instruction unit 312, a warning unit 313, a management unit 314, and a modification unit 315.

[0029] The acquisition unit 311 acquires state information including the presence or absence of abnormalities in the cell culture system 100 from the PLC 20.

[0030] The instruction unit 312 receives the stop operation of the user and outputs a stop instruction to the PLC 20 to stop any one or all of the devices among the incubator 130, the clean bench 140, and the stocker 110.

[0031] The warning unit 313 displays on the display unit 35 the elapsed time since one or all of the devices of the cell culture system 100 were stopped. Further, when the information acquired by the acquisition unit 311 includes information indicating that an abnormality has occurred in the acquired state information, the warning unit 313 displays a message on the display unit 35.

[0032] The management unit 314 creates project status information that allows the status of each project to be viewed and displays it on the display unit 35. Further, in the present embodiment, the management unit 314 identifies a project that has been abnormally stopped due to the stoppage of a device. The project status information includes information indicating whether or not each project has been abnormally stopped.

[0033] The change unit 315 accepts a user's schedule change operation and changes the culture schedule for each project.

[0034] Note that the predetermined program executed by the processor 31 is stored in a computer-readable recording medium. The computer-readable recording medium refers to a magnetic disk, a magneto-optical disk, a CD-ROM, a DVD-ROM, a semiconductor memory, or the like. Further, this computer program may be distributed to a computer via a communication line, and the computer that has received this distribution may execute the program. Furthermore, this program may be for realizing a part of the above-described functions. Furthermore, it may be a so-called difference file (difference program) that can realize the above-described functions in combination with a program already recorded in the computer system.

[0035] The memory 32 has a memory area necessary for the operation of the processor 31.

[0036] The storage 33 is a so-called auxiliary storage device, such as an HDD (Hard Disk Drive) or an SSD (Solid State Drive). The storage 33 stores data such as data acquired, generated, and referred to by each part of the processor 31 during processing.

[0037] The communication interface 34 is an interface for transmitting and receiving various data, control signals, etc. with the PLC 20.

[0038] The display unit 35 is a display device for displaying a management screen for managing each project, a message when an abnormality occurs, information such as the elapsed time since the device stopped, etc., and is, for example, a liquid crystal display or an organic EL display.

[0039] The input unit 36 is an input device that accepts user operations, and is, for example, a general mouse, keyboard, touch sensor, etc.

[0040] (Management screen) Next, with reference to FIGS. 4 to 6, the management screen D1 displayed by the management device 30 will be described. FIG. 4 shows an example of the management screen D1 displayed on the display unit 35 of the management device 30. The management screen D1 is a screen that can be accessed only by authenticated users.

[0041] For example, when user authentication is completed, the management screen D1 shown in FIG. 4 is displayed on the display screen. On this management screen D1, a project list D10 listing each project that the cell culture system 100 is in progress or has completed is displayed.

[0042] In the project list D10, project status information D11 created by the management department 314 is displayed. The project status information D11 includes items such as identification information, start date, progress, status, cryopreservation date, etc. of each project. In the identification information column, the project number, project name, project code, etc. are displayed. In the start date column, the date when the project was started is displayed. In the progress column, the number of working days completed with respect to the total number of days of the project is displayed. In the status column, the implementation status of the project (before start, in culture, abnormal stop, completed) is displayed. In the cryopreservation date column, the date when the cells were cryopreserved by subculture operation or the number of days elapsed since cryopreservation is displayed. For example, if the cells die due to abnormal stop, the cryopreserved cells can be used to resume culture from the state on the cryopreservation date. By referring to the cryopreservation date, the user can grasp the number of days required when restarting the culture. Also, in the project list D10, a start button B15 and a stop button B16 for performing the start or stop (temporary stop) operation of each project are arranged.

[0043] The user can individually start or stop (temporarily stop) the project by pressing the start button B15 or the stop button B16 in the project list D10. As in the example of FIG. 4, the start button B15 is displayed for a project before start or in temporary stop, and the stop button B16 is displayed for a project in culture. Also, neither the start button B15 nor the stop button B16 is displayed for a completed project.

[0044] In addition, the management screen D1 has a menu button B10, an incubator stop button B11, a clean bench stop button B12, a stocker stop button B13, and an all-stop button B14. When the user presses the menu button B10, a management menu D20 (Fig. 5) is displayed on the management screen D1. When the user presses the incubator stop button B11, the clean bench stop button B12, or the stocker stop button B13, the instruction unit 312 of the management device 30 outputs an operation instruction to stop the device corresponding to the button to the PLC 20. Also, when the user presses the all-stop button B14, the instruction unit 312 of the management device 30 outputs an operation instruction to simultaneously stop all of the incubator 130, the clean bench 140, and the stocker 110 to the PLC 20. The PLC 20 performs control to stop the operation of each device according to the operation instruction of the management device 30.

[0045] Note that when the incubator 130 is stopped, the cells of all projects in operation may die. Therefore, the operation authorities (operability) of the incubator stop button B11, the clean bench stop button B12, the stocker stop button B13, and the all-stop button B14 may be made different according to the user so that only a skilled user can stop the incubator 130. For example, when the logged-in user has all operation authorities, the instruction unit 312 enables the operation of each stop button B11 to B14. On the other hand, when the logged-in user has only limited operation authorities, the instruction unit 312 enables only the operation of the stocker stop button B13 and disables the operation of the other stop buttons B11, B12, and B14 (gray out or hide them). These are just examples, and the user's operation authorities and the combination of operable stop buttons may be arbitrarily changed.

[0046] FIG. 5 shows an example of the management menu D20. The management menu D20 has a project list button B21 and an abnormality occurrence history button B22. When the user presses the project list button B21, a project list D10 (FIG. 4) is displayed on the management screen D1. Also, when the user presses the abnormality occurrence history button B22, an abnormality occurrence history D30 (FIG. 6) is displayed on the management screen D1.

[0047] FIG. 6 shows an example of the abnormality occurrence history D30 created by the warning unit 313. The abnormality occurrence history includes abnormality log data D31 and abnormality occurrence location information D32. The abnormality log data D31 is a list of information indicating abnormalities in the cell culture system 100 detected by the PLC20 among the state information acquired from the PLC20. The abnormality log data D31 includes a log code, log content (abnormality occurrence location, content of the abnormality, presence or absence of automatic stop of the device, etc.), date and time of occurrence, etc. The abnormality occurrence location information D32 includes a configuration diagram schematically representing the configuration of each device of the cell culture system 100 (arm for gripping the workpiece W, heating device, humidifying device, etc.), a mark M indicating which configuration on the configuration diagram has an abnormality, etc. In the example of FIG. 6, it can be seen from the mark M that the PLC20 detected an abnormality in the configuration P406 of the incubator 130. Note that instead of the mark M, by changing the display mode (for example, changing the color or size, blinking, etc.), it may be shown which location (configuration) has an abnormality. The user can narrow down the period during which an abnormality occurred by operating the button B31 in the abnormality occurrence history D30 and display only the desired abnormality log data D31.

[0048] Also, when the PLC20 detects an abnormality, as shown in FIG. 6, a message D12 is displayed on the management screen D1. Note that although FIG. 6 shows an example in which the message D12 is displayed together with the abnormality occurrence history D30, it is not limited to this. The message D12 may be displayed together with the project list D10 (FIG. 4) and the management menu D20 (FIG. 5).

[0049] (Processing Flow) Next, while referring to the flowchart shown in FIG. 7, the flow of the abnormality monitoring process of the management device 30 and the stop / resume process in case of an abnormality will be described.

[0050] The acquisition unit 311 acquires status information from the PLC 20 (step S101). Further, the warning unit 313 determines whether the PLC 20 has detected an abnormality in the cell culture system 100 (step S102). If the status information does not include abnormality log data (step S102; NO), the warning unit 313 proceeds to step S105. On the other hand, when the acquired status information from the PLC 20 includes predetermined abnormality log data, the warning unit 313 determines that the PLC 20 has detected an abnormality (step S102; YES), and displays the message D12 (FIG. 6) (step S103). The predetermined abnormality log data is data having a log code or log content set in advance by the user, and indicates, for example, malfunction of the incubator 130, the clean bench 140, the stocker 110, etc.

[0051] Also, based on the status information, the warning unit 313 determines whether the PLC 20 has detected an abnormality and automatically stopped the devices of the cell culture system 100 (step S104). When the PLC 20 detects an abnormality, if the abnormality is not resolved even after retrying a plurality of times, the PLC 20 may automatically stop the device in which the abnormality has been detected. When the PLC 20 has performed an automatic stop, the warning unit 313 displays an elapsed time D13 (FIG. 8) including the elapsed time from the automatic stop (step S107).

[0052] As shown in FIG. 8, the elapsed time D13 is displayed in the form of a pop-up message on the management screen D1 (which may be any of the project list D10, the management menu D20, and the abnormality occurrence history D30), including the name of the stopped device and the minutes and seconds since the stop. Also, the color, size, etc. of the characters may be arbitrarily set so as to easily draw the user's attention.

[0053] On the one hand, when PLC20 is not automatically stopped (step S104; NO), when the user checks message D12, the user visually checks the abnormality occurrence history D30 (Fig. 6) and each device of the cell culture system 100, and operates the stop buttons B11 to B14 as necessary. Also, when PLC20 has not detected an abnormality and message D12 is not displayed (step S102; NO), if the user discovers an abnormality in the device or operation (for example, the dispensing operation is being performed while the UV sterilization device is operating in the clean bench 140) or an abnormality such as contamination, the user operates the stop buttons B11 to B14 as necessary. When none of the stop buttons B11 to B14 is pressed (step S105; NO), the management device 30 returns to step S101. On the other hand, when the instruction unit 312 receives the pressing of any of the stop buttons B11 to B14 (step S105; YES), the instruction unit 312 outputs an operation instruction to stop the device corresponding to the pressed button to PLC20 (step S106). PLC20 performs control to stop the operation of the designated device according to the operation instruction of the management device 30. Also, the warning unit 313 displays the elapsed time D13 (Fig. 8) since the device was stopped (step S107).

[0054] For example, in step S105, assume that the pressing of the clean bench stop button B12 is received. In this case, in step S106, the instruction unit 312 outputs an operation instruction to stop the operation of the clean bench 140 to PLC20. Also, in step S107, the warning unit 313 displays the elapsed time D13 (Fig. 8) since the clean bench 140 was stopped.

[0055] Next, the management unit 314 changes the status of the project interrupted by the stop of the equipment (clean bench 140) to "abnormal stop" (step S108). For example, assume that the clean bench 140 was performing the transfer operation of project No. 2. At this time, as shown in FIG. 8, the management unit 314 changes the status of project No. 2 from "culturing" to "abnormal stop", and switches the button display in the start / suspend column to the start button B15. Thereby, the user can easily grasp which project is affected by the stop of the clean bench 140 by referring to the project list D10.

[0056] The warning unit 313 determines whether the elapsed time since the equipment was stopped is less than a preset allowable time (step S109). As described above, if the period during which the equipment is stopped due to an abnormality becomes long, there is a possibility that effects such as cell death may occur. Therefore, the allowable time is set to a time such that such effects do not occur. Also, different allowable times may be set according to which of the incubator 130, the clean bench 140, and the stocker 110 has stopped.

[0057] First, the case where the elapsed time has not exceeded the allowable time (steps S110 to S115) will be described. When the elapsed time since the equipment was stopped is less than the allowable time (step S109; YES), the warning unit 313 continues to display the elapsed time D13. Also, at this time, the management device 30 enables the user to accept both the restart operation and the rescheduling operation of the project during abnormal stop. For example, when the user presses the start button B15 of project No. 2 during abnormal stop, the management device 30 displays the restart message D14 shown in FIG. 9. The restart message D14 displays a message "Do you want to start the project from the middle?", a restart button B17 ("Yes"), and a reschedule button B18 ("No").

[0058] When the pressing of the resume button B17 of the resume message D14 is received (step S110; YES), the instruction unit 312 outputs an operation instruction to start the operation of the stopped device to the PLC 20 (step S111). The PLC 20 performs control to start the operation of the designated device according to the operation instruction of the management device 30. Further, the warning unit 313 erases the display of the elapsed time D13 (step S112). Furthermore, the management unit 314 changes the state of the resumed project No. 2 from "abnormal stop" to "culturing", and switches the button display in the start / suspend column to the suspend button B16 (step S113). After the resumption of the project, the management device 30 returns to step S101 and repeatedly executes the series of processes in FIG. 7.

[0059] On the other hand, when the pressing of the reschedule button B18 of the resume message D14 is received (step S110; NO), the change unit 315 displays a schedule editing screen (not shown) on the management screen D1 and accepts a change operation of the culture schedule of the project No. 2 during abnormal stop (step S114). For example, when the user determines that it is necessary to redo the work process with the cryopreserved cells, the user presses the reschedule button B18. The user adjusts and reschedules the work process that was being carried out at the time of abnormal stop and the subsequent work processes so as not to overlap with the execution date and time of the work processes of other projects and the equipment used. The change unit 315 registers the changed culture schedule input by the user as the new culture schedule of the project No. 2 that has stopped abnormally (step S115). Further, when the registration of the new culture schedule is completed, the instruction unit 312 outputs an operation instruction to start the operation of the stopped device to the PLC 20 (step S111). The PLC 20 performs control to start the operation of the designated device according to the operation instruction of the management device 30. Further, the warning unit 313 erases the display of the elapsed time D13 (step S112). Furthermore, the management unit 314 changes the state of the resumed project No. 2 from "abnormal stop" to "culturing", and switches the button display in the start / suspend column to the suspend button B16 (step S113). After the resumption of the project, the management device 30 returns to step S101 and repeatedly executes the series of processes in FIG. 7.

[0060] Next, a case where the elapsed time has passed the allowable time (Steps S116 to S118) will be described. When the elapsed time since the device stopped is equal to or greater than the allowable time (Step S109; NO), the warning unit 313 displays a first warning D15 (FIG. 10) indicating that the allowable time has been exceeded (Step S116). As shown in FIG. 10, the first warning D15 may display text indicating that the allowable time has been exceeded, or may display a diagram or the like. Also, the content of the first warning D15 may differ depending on the stopped device.

[0061] Also, when the elapsed time is equal to or greater than the allowable time, the instruction unit 312 prohibits the user from performing a restart operation (Step S117). Specifically, the instruction unit 312 grays out the restart button B17 of the restart message D14 so that the user cannot press it. Also, as in the example of FIG. 10, the restart button B17 may be hidden by the first warning D15 or the like.

[0062] Therefore, when the elapsed time becomes equal to or greater than the allowable time, the management device 30 enables only the rescheduling operation of the project that is abnormally stopped. When the change unit 315 receives the pressing of the rescheduling button B18 of the restart message D14 (Step S118), it receives the change operation of the culture schedule of project No. 2 that is abnormally stopped (Step S114). Since the rescheduling process (Steps S114 to S115) and the subsequent processes (Steps S111 to S113) are the same as those described above, the description thereof is omitted.

[0063] In addition, in this embodiment, the warning unit 313 has been described as an example of displaying the first warning D15 only when the elapsed time is equal to or greater than the allowable time, but it is not limited to this. In other embodiments, the warning unit 313 may display a second warning D16 (FIG. 11) after the device stops until the elapsed time becomes equal to or greater than the allowable time. As shown in FIG. 11, the second warning D16 includes, for example, the remaining time until the allowable time and a message (text, figure, etc.) prompting the user to perform an operation such as restart. Further, the display mode of the second warning D16 may be changed so that it is more likely to attract the user's attention as the remaining time decreases (for example, enlarging the message, changing the color, flashing, etc.).

[0064] Furthermore, the warning unit 313 may vary the display modes of the elapsed time D13, the first warning D15, and the second warning D16 according to the stopped device. For example, when the incubator 130 is stopped, the cells of all projects during operation may die. Therefore, for a device such as the incubator 130 that has a large impact due to stopping, the warning unit 313 may display it in a display mode that is more likely to attract the user's attention than other devices (for example, enlarging the message, changing the color, flashing, etc.), and may also output a warning sound or a voice message at the same time.

[0065] (Function and effect) As described above, the management device 30 according to this embodiment includes an instruction unit 312 that receives a stop operation from the user and outputs a stop instruction to the PLC 20 to stop any one or all of the incubator 130, the clean bench 140, and the stocker 110, and a warning unit 313 that displays the elapsed time since the device stopped.

[0066] By doing so, when the user stops some or all of the devices of the cell culture system, the management device 30 can easily make the user recognize the elapsed time since the stop.

[0067] In addition, the management device 30 further includes an acquisition unit 311 that acquires status information including the presence or absence of abnormalities in the cell culture system 100 from the PLC 20. When the status information includes information indicating that an abnormality has occurred in the cell culture system 100, the warning unit 313 displays the message D12.

[0068] By doing so, the management device 30 can promptly notify the user that the PLC 20 has automatically detected an abnormality. As a result, the user can quickly take measures to reduce the impact on the cells due to the abnormality, such as checking the abnormality occurrence history D30 of the PLC 20 and visually inspecting the cell culture system 100, and stopping the equipment as necessary.

[0069] In addition, the management device 30 further includes a management unit 314 that identifies and displays the project that has been abnormally stopped due to the stoppage of the equipment.

[0070] By doing so, the management device 30 can easily let the user know which project is affected by the stoppage of the equipment.

[0071] In addition, the management unit 314 displays the timing when the cells were last cryopreserved in the project.

[0072] By doing so, when it becomes necessary to restart the culture using the cryopreserved cells due to the stoppage of the equipment, the management device 30 can let the user know the number of days required for the restart.

[0073] In addition, when the elapsed time exceeds the preset allowable time, the warning unit 313 displays a first warning D15 indicating that the allowable time has been exceeded, and when the elapsed time exceeds the allowable time, the instruction unit 312 restricts the restart operation of the abnormally stopped project (pressing the restart button B17).

[0074] By doing so, when it is estimated that the management device 30 has caused damage to the cells being operated that cannot be resumed due to the stoppage of the equipment, the user can be made aware that it is difficult to resume the work process for these cells. Therefore, even an inexperienced user can easily understand whether they should resume the stopped project from the middle or start over from the beginning of the work process.

[0075] Also, the warning unit 313 displays a second warning D16 that includes the remaining time until the allowable time and a message prompting the resumption operation of the project until the elapsed time reaches the allowable time or more.

[0076] By doing so, the management device 30 can easily make the user understand what needs to be done by when. This can prompt the user to quickly respond to the abnormality.

[0077] The management device 30 further includes a change unit 315 that accepts the user's schedule change operation and changes the culture schedule of the abnormally stopped project.

[0078] By doing so, the management device 30 can cause the user to change the culture schedule so that the abnormally stopped project can be resumed.

[0079] Also, the instruction unit 312 permits or restricts the stop operations of the incubator 130, the clean bench 140, and the stocker 110 based on the operation authorities given in advance to each of the plurality of users.

[0080] By doing so, the management device 30 can reduce the possibility that an inexperienced user will inadvertently stop the equipment.

[0081] <Other Embodiments> As described above, one embodiment has been described in detail with reference to the drawings. However, the specific configuration is not limited to the above, and various design changes and the like can be made. That is, in other embodiments, the order of the above-described processes may be appropriately changed. Also, some processes may be executed in parallel.

[0082] Also, in the above-described embodiment, the mode in which the management device 30 displays information to the user and accepts the user's operations through the display unit 35 and the input unit 36 directly connected to itself has been described. However, the present invention is not limited to this. In other embodiments, the management device 30 may use a terminal device connected via a cloud server or the like instead of the display unit 35 and the input unit 36. The terminal device is a computer such as a notebook PC, a smartphone, or a tablet carried by the user.

[0083] <Appendix> The management device, management system, and program described in the above-described embodiment are understood as follows, for example.

[0084] (1) According to the first aspect, the management device 30 is a management device of a cell culture system 100 having an incubator 130 that forms a culture area R3 for culturing cells in a workpiece W, a clean bench 140 that forms a liquid operation area R4 for performing a dispensing operation on the workpiece W, and a stocker 110 that stores the workpiece W used in the clean bench 140. The management device includes an instruction unit 312 that receives a stop operation of the user and outputs a stop instruction to stop any one or all of the incubator 130, the clean bench 140, and the stocker 110 to a PLC 20 (Programmable Logic Controller) that controls the cell culture system 100, and a warning unit 313 that displays the elapsed time since the device was stopped.

[0085] By doing so, when the user stops some or all of the devices of the cell culture system, the management device 30 can easily make the user recognize the elapsed time since the stop.

[0086] (2) According to the second aspect, the management device 30 according to the first aspect further includes an acquisition unit 311 that acquires status information including the presence or absence of abnormalities in the cell culture system 100 from the PLC 20, and the warning unit 313 displays the message D12 when the status information includes information indicating that an abnormality has occurred in the cell culture system 100.

[0087] By doing so, the management device 30 can promptly notify the user that the PLC 20 has automatically detected an abnormality. As a result, the user can quickly take measures to reduce the impact of the abnormality on the cells, such as checking the abnormality occurrence history D30 of the PLC 20 and visually inspecting the cell culture system 100, and stopping the equipment as necessary.

[0088] (3) According to the third aspect, in the management device 30 according to the second aspect, the warning unit 313 displays information indicating the location where an abnormality has occurred on the configuration diagram of the cell culture system 100 based on the status information.

[0089] By doing so, the management device 30 can easily let the user recognize where (which component) an abnormality has occurred in the cell culture system 100. As a result, the user can more quickly visually inspect the location where the abnormality has occurred and determine whether to stop the equipment.

[0090] (4) According to the fourth aspect, the management device 30 according to any one of the first to third aspects further includes a management unit 314 that identifies and displays the project that has been abnormally stopped due to the stop of the equipment.

[0091] By doing so, the management device 30 can easily let the user grasp which project is affected by the stop of the equipment.

[0092] (5) According to the fifth aspect, in the management device 30 according to the fourth aspect, the management unit 314 displays the timing when the cells were last cryopreserved in the project.

[0093] By doing so, when it becomes necessary to restart the culture using the cells cryopreserved due to the stoppage of the equipment, the management device 30 can make the user aware of the number of days required for the restart.

[0094] (6) According to the sixth aspect, in the management device 30 according to any one of the first to fifth aspects, when the elapsed time becomes equal to or longer than a preset allowable time, the warning unit 313 displays a first warning D15 indicating that the allowable time has been exceeded, and when the elapsed time becomes equal to or longer than the allowable time, the instruction unit 312 restricts the restart operation of the abnormally stopped project.

[0095] By doing so, when it is presumed that damage has occurred to the cells being operated due to the stoppage of the equipment, making it impossible to restart them, the management device 30 can make the user aware that it is difficult to restart the work process for these cells. Therefore, even an inexperienced user can easily understand whether to restart the stopped project from the middle or to start over from the beginning of the work process.

[0096] (7) According to the seventh aspect, in the management device 30 according to the sixth aspect, until the elapsed time becomes equal to or longer than the allowable time, the warning unit 313 displays a second warning D16 including the remaining time until the allowable time and a message prompting the restart operation of the project.

[0097] By doing so, the management device 30 can easily make the user aware of what needs to be done by when. Thereby, it is possible to prompt the user to quickly deal with the abnormality.

[0098] (8) According to the eighth aspect, the management device 30 according to any one of the first to seventh aspects further includes a change unit 315 that accepts a user's schedule change operation and changes the culture schedule of the abnormally stopped project.

[0099] By doing so, the management device 30 can cause the user to change the culture schedule so that the abnormally stopped project can be restarted.

[0100] (9) According to the ninth aspect, in the management device 30 according to any one of the first to eighth aspects, the instruction unit 312 permits or restricts the stop operations of the incubator 130, the clean bench 140, and the stocker 110 based on the operation authorities given in advance to each of the plurality of users.

[0101] By doing so, the management device 30 can reduce the possibility that an inexperienced user inadvertently stops the equipment.

[0102] (10) According to the tenth aspect, the management method is a management method of the cell culture system 100 including an incubator 130 that forms a culture area R3 for culturing cells with a workpiece W, a clean bench 140 that forms a liquid operation area R4 for performing a dispensing operation on the workpiece W, and a stocker 110 that stores the workpiece W used in the clean bench 140, the method including: receiving a stop operation of a user and outputting a stop instruction for stopping any one or all of the incubator 130, the clean bench 140, and the stocker 110 to a PLC 20 (Programmable Logic Controller) that controls the cell culture system 100; and displaying an elapsed time since the equipment was stopped.

[0103] (11) According to the 11th aspect, the program causes a management device of a cell culture system 100 having an incubator 130 that forms a culture area R3 for culturing cells with a work W, a clean bench 140 that forms a liquid operation area R4 for performing a dispensing operation on the work W, and a stocker 110 that stores the work W used in the clean bench 140, to accept a stop operation by a user and output a stop instruction to stop any one or all of the incubator 130, the clean bench 140, and the stocker 110 to a PLC 20 (Programmable Logic Controller) that controls the cell culture system 100, and to execute a step of displaying the elapsed time since the device was stopped.

Explanation of Signs

[0104] 100 Cell culture system 110 Stocker 130 Incubator 140 Clean bench 150 Pass box 160 Measuring device 161 Medium supply device 162 Waste liquid tank 200 Management system 20 PLC (Programmable Logic Controller) 30 Management device 31 Processor 311 Acquisition unit 312 Instruction unit 313 Warning unit 314 Management unit 315 Change unit 32 Memory 33 Storage 34 Communication interface 35 Display unit 36 Input unit W Work< / plc>

Claims

1. An incubator that forms a culture area for culturing cells on a workpiece, a clean bench that forms a liquid operation area for performing a dispensing operation on the workpiece, and a stocker that stores the workpiece used in the clean bench. A management device for a cell culture system, comprising: An instruction unit that receives a stop operation from a user and outputs a stop instruction to stop any one or all of the incubator, the clean bench, and the stocker to a PLC (Programmable Logic Controller) that controls the cell culture system; A warning unit that displays the elapsed time since the device was stopped; A management device comprising the above.

2. Further comprising an acquisition unit that acquires status information including the presence or absence of abnormalities in the cell culture system from the PLC, When the status information includes information indicating that an abnormality has occurred in the cell culture system, the warning unit displays a message. The management device according to claim 1.

3. The warning unit displays information indicating the location where an abnormality has occurred on the configuration diagram of the cell culture system based on the status information. The management device according to claim 2.

4. Further comprising a management unit that identifies and displays the project that was abnormally stopped due to the stop of the device. The management device according to claim 1.

5. The management unit displays the timing when the cells were last cryopreserved in the project. The management device according to claim 4.

6. When the elapsed time exceeds a preset allowable time, the warning unit displays a first warning indicating that the allowable time has been exceeded. When the elapsed time becomes equal to or greater than the allowable time, the instruction unit restricts the restart operation of the abnormally stopped project. The management device according to claim 4.

7. Before the elapsed time reaches the allowable time, the warning unit displays a second warning including the remaining time until the allowable time and a message prompting the restart operation of the project. The management device according to claim 6.

8. Further comprising a change unit that receives a schedule change operation from the user and changes the culture schedule of the abnormally stopped project. The management device according to claim 4.

9. ​ ​ ​ ​ ​ ​ ​ ​ The instruction unit permits or restricts the stop operations of the incubator, the clean bench, and the stocker based on the operation authorities given in advance to each of a plurality of users. The management device according to any one of claims 1 to 8.

10. A management method for a cell culture system, comprising: an incubator that forms a culture area for culturing cells in a workpiece; a clean bench that forms a liquid operation area for performing a dispensing operation on the workpiece; and a stocker that stores the workpiece used in the clean bench. A step of receiving a stop operation from a user and outputting a stop instruction for stopping any one or all of the incubator, the clean bench, and the stocker to a PLC (Programmable Logic Controller) that controls the cell culture system. A step of displaying the elapsed time since the device was stopped. A management method comprising the above steps.

11. In a management device for a cell culture system, comprising: an incubator that forms a culture area for culturing cells in a workpiece; a clean bench that forms a liquid operation area for performing a dispensing operation on the workpiece; and a stocker that stores the workpiece used in the clean bench. A step of receiving a stop operation from a user and outputting a stop instruction for stopping any one or all of the incubator, the clean bench, and the stocker to a PLC (Programmable Logic Controller) that controls the cell culture system. A step of displaying the elapsed time since the device was stopped. A program for causing the above steps to be executed.

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