Oral composition and container-filled oral composition

Abstract

To inhibit inhomogenization of a specific fluorine compound in an oral composition.SOLUTION: An oral composition includes: at least one specific fluorine compound selected from sodium fluoride, sodium monofluorophosphate, and stannous fluoride; a lauroyl glutamate salt; at least one nicotinic acid compound selected from nicotinic acid, a nicotinic acid salt, and a nicotinic acid derivative; an abrasive silica; and water. The oral composition has fluorine concentration of 0.005 mass% or more and 0.2 mass% or less. The content of the abrasive silica is 0.75 mass% or more and 50 mass% or less. The ratio of the content of the abrasive silica to the fluorine concentration (content of abrasive silica / fluorine concentration) is 150 or more.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an oral composition and an oral composition in a container.

Background Art

[0002] Patent Document 1 discloses an oral composition containing sodium lauroyl glutamate and nicotinic acid.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] In an oral composition, a fluorine compound may be blended as a caries-preventing component. The present inventors conducted research on an oral composition containing a specific fluorine compound such as sodium fluoride, a lauroyl glutamate salt such as sodium lauroyl glutamate, and a nicotinic acid compound such as nicotinic acid. In that research, when the oral composition was left standing under specific conditions for a long period of time, a problem occurred in that the specific fluorine compound became non-uniform.

Means for Solving the Problems

[0005] The present inventors have found that by blending a specific amount of abrasive silica in addition to the specific fluorine compound, lauroyl glutamate salt, and nicotinic acid compound, non-uniformity of the specific fluorine compound can be suppressed.

[0006] Each aspect for solving the above problems will be described. [Aspect 1] An oral composition comprising at least one specific fluorine compound selected from sodium fluoride, sodium monofluorophosphate, and stannous fluoride, lauroyl glutamate, at least one nicotinic acid compound selected from nicotinic acid, nicotinic acid salts, and nicotinic acid derivatives, abrasive silica, and water, having a fluorine concentration of 0.005% by mass or more and 0.2% by mass or less, a compounding amount of the abrasive silica of 0.75% by mass or more and 50% by mass or less, and a ratio of the compounding amount of the abrasive silica to the fluorine concentration (compounding amount of abrasive silica / fluorine concentration) of 150 or more.

[0007] [Aspect 2] The oral composition according to [Aspect 1], wherein the compounding amount of the specific fluorine compound is 0.01% by mass or more and 1.52% by mass or less, the compounding amount of the lauroyl glutamate is 0.01% by mass or more and 5% by mass or less, and the compounding amount of the nicotinic acid compound is 0.01% by mass or more and 5% by mass or less.

[0008] [Aspect 3] The oral composition according to [Aspect 1] or [Aspect 2], wherein the ratio of the total compounding amount of the lauroyl glutamate and the nicotinic acid compound to the fluorine concentration (total compounding amount / fluorine concentration) is 0.1 or more and 2000 or less.

[0009] [Aspect 4] The oral composition according to any one of [Aspect 1] to [Aspect 3], having a viscosity of 50 Pa·s or more and 300 Pa·s or less.

[0010] [Aspect 5] The oral composition according to any one of [Aspect 1] to [Aspect 4], wherein the average particle diameter of the abrasive silica is 0.5 μm or more and 50 μm or less.

[0011] [Aspect 6] An oral composition in a container, comprising the oral composition according to any one of [Aspect 1] to [Aspect 5] and a container for containing the oral composition, wherein the container is a container made of polyethylene. [Advantages of the Invention]

[0012] According to the present invention, it is possible to suppress the non-uniformity of a specific fluorine compound in an oral composition.

Mode for Carrying Out the Invention

[0013] Embodiments embodying the oral composition and the oral composition in a container of the present invention will be described. In the present specification, the oral composition means a composition mainly intended for use in the oral cavity, and includes not only oral preparations discharged from the oral cavity after use but also ingestible foods and drinks. The oral composition and the oral composition in a container of the present embodiment are not limited to those intended for use in the oral cavity.

[0014] <Oral composition> The oral composition contains (A) a specific fluorine compound, (B) lauroyl glutamate, (C) a nicotinic acid compound, (D) abrasive silica, and (E) water. Further, the oral composition may contain, as an optional component, (F) other components other than the above components.

[0015] The viscosity of the oral composition is, for example, 50 Pa·s or more, preferably 100 Pa·s or more. Further, the viscosity of the oral composition is, for example, 300 Pa·s or less, preferably 220 Pa·s or less. The oral composition is, for example, paste-like, gel-like, ointment-like, mud-pack-like, or cream-like.

[0016] (Component A: Specific fluorine compound) The specific fluorine compound is, for example, formulated as a caries prevention component. The specific fluorine compound is at least one selected from sodium fluoride, sodium monofluorophosphate, and stannous fluoride. The oral composition may contain only one kind of the above specific fluorine compound alone, or may contain a combination of two or more kinds.

[0017] (Component B: Lauroyl glutamate) Lauroyl glutamate is formulated, for example, as a bactericidal component. Examples of lauroyl glutamate include alkali metal salts. Lauroyl glutamate is preferably a sodium salt or a potassium salt, more preferably a sodium salt. The oral composition may contain only one of the above lauroyl glutamates alone, or may contain a combination of two or more thereof.

[0018] (Component C: Nicotinic acid compound) The nicotinic acid compound is formulated, for example, as an anti-inflammatory component. The nicotinic acid compound is at least one selected from nicotinic acid, nicotinic acid salts, and nicotinic acid derivatives. Examples of nicotinic acid salts include sodium salts and potassium salts. Examples of nicotinic acid derivatives include 2-hydroxy nicotinic acid, isonicotinic acid, 2-chloro nicotinic acid, methyl nicotinate, amino nicotinic acid, and nicotinamide. The oral composition may contain only one of the above nicotinic acid compounds alone, or may contain a combination of two or more thereof.

[0019] (Component D: Abrasive silica) In the oral composition of the present embodiment, the abrasive silica is formulated for the purpose of suppressing the non-uniformity of a specific fluorine compound.

[0020] Generally, silica formulated in an oral composition includes abrasive silica for the purpose of polishing teeth and thickening silica for the purpose of thickening the composition. Abrasive silica has a lower oil absorption than thickening silica. In this specification, abrasive silica means silica having an oil absorption of less than 2 mL / g. The oil absorption in this specification means the oil absorption measured in accordance with JIS K5101-13-2:2004.

[0021] Examples of abrasive silica include compounds mainly composed of silicic anhydride such as precipitated silica and addition silica, aluminosilicates, zirconosilicates, and silicates such as titanium-bonded silica. The oral composition may contain only one kind of the above abrasive silica alone, or may contain a combination of two or more kinds.

[0022] The average particle size of the abrasive silica is, for example, 0.5 μm or more, preferably 2 μm or more. Also, the average particle size of the abrasive silica is, for example, 50 μm or less, preferably 20 μm or less. The above average particle size means the particle size at the integrated value of 50% in the particle size distribution determined by the laser diffraction / scattering method.

[0023] (Component E: Water) Water is contained as a solvent in the oral composition. The type of water contained in the oral composition is not particularly limited, and for example, distilled water, pure water, ultrapure water, purified water, and tap water can be used. Also, the water contained in the oral composition may be a mixed solvent with an alcohol such as ethanol. The blending amount of water (in the case of a mixed solvent, the blending amount of the mixed solvent) is, for example, 5% by mass or more and 90% by mass or less.

[0024] (Component F: Other Components) The oral composition may contain other components other than the above components as necessary. Examples of other components include surfactants, flavoring agents, fragrances, sweeteners, wetting agents, binders, preservatives, coloring agents, pH adjusters, chelating agents, medicinal components, bases, abrasives, stabilizers, etc. Known ones blended in the oral composition can be used for other components. The oral composition may contain only one kind of each of the above other components alone, or may contain a combination of two or more kinds.

[0025] Examples of surfactants include nonionic surfactants, anionic surfactants, amphoteric surfactants, and cationic surfactants. Examples of nonionic surfactants include polyoxyethylene glycerol fatty acid esters, polyoxyethylene sorbitol fatty acid esters, polyethylene glycol fatty acid esters, polyethylene lanolin, polyethylene sterol, polyethylene lanolin alcohol, alkyl glucosides, polyoxyethylene-polyoxypropylene block copolymers; sugar fatty acid esters such as sucrose fatty acid esters, maltose fatty acid esters, lactose fatty acid esters; fatty acid alkanolamides; glycerol fatty acid esters; sorbitan fatty acid esters; fatty acid monoglycerides; polyoxyethylene alkyl ethers with a polyoxyethylene addition coefficient of 8 - 10 and an alkyl group having 13 - 15 carbon atoms; polyoxyethylene alkyl phenyl ethers with a polyoxyethylene addition coefficient of 10 - 18 and an alkyl group having 9 carbon atoms; diethyl sebacate; polyoxyethylene hydrogenated castor oil; fatty acid polyoxyethylene sorbitan, and the like.

[0026] Examples of anionic surfactants include sulfate esters such as sodium lauryl sulfate, sodium polyoxyethylene lauryl ether sulfate; sulfosuccinates such as sodium lauryl sulfosuccinate, sodium polyoxyethylene lauryl ether sulfosuccinate; acyl amino acid salts such as sodium lauroyl methyl alanine; sodium cocoyl methyl taurine, sodium cocoyl sarcosine, and the like.

[0027] Examples of amphoteric surfactants include betaine-type surfactants such as lauryldimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine; imidazoline-type surfactants such as N-cocoyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine sodium; amino acid-type surfactants such as N-lauryl diaminoethyl glycine, and the like.

[0028] Examples of cationic surfactants include distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, N-coconut oil fatty acid acyl-L-arginine ethyl · DL-pyrrolidone carboxylate, and the like.

[0029] Examples of flavoring agents and fragrances include, for example, linalool, ethyl linalool, coriander oil, menthol, carboxylic acid, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronellol, α-terpineol, methyl acetate, citronellyl acetate, methyl eugenol, cineole, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil, pimento oil, d-camphor, d-borneol, star anise oil, cinnamon oil, anise oil, cinnamaldehyde, mint oil, vanillin, etc.

[0030] Examples of sweeteners include, for example, saccharin, stevia extract, glycyrrhizin, soymatin, palatinose, palatinit, erythritol, maltitol, xylitol, lactitol, sodium saccharin, acesulfame potassium, stevioside, neohesperidin dihydrochalcone, perillartine, thaumatin, aspartyl phenylalanine methyl ester, p-methoxycinnamic aldehyde, etc.

[0031] Examples of wetting agents include, for example, sorbitol, ethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, polypropylene glycol, xylitol, maltitol, lactitol, polyoxyethylene glycol, etc.

[0032] Examples of the binder include cellulose derivatives such as sodium carboxymethyl cellulose, carboxymethyl ethyl cellulose salt, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, ethyl cellulose, crystalline cellulose, and crystalline cellulose - sodium carmellose; microbial - produced polymers such as xanthan gum; natural polymers or natural gums such as tragacanth gum, karaya gum, gum arabic, guar gum, carrageenan, dextrin, agar, pectin, pullulan, gellan gum, locust bean gum, and sodium alginate; synthetic polymers such as polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, polyvinyl methyl ether, and sodium polyacrylate; inorganic binders such as thickening silica and beegum; cationic binders such as O - [2 - hydroxy - 3 - (trimethylammonio)propyl] hydroxyethyl cellulose chloride, etc.

[0033] Examples of the preservative include parabens such as methyl paraben, ethyl paraben, propyl paraben, and butyl paraben; sodium benzoate, phenoxyethanol, and alkyldiaminoethyl glycine hydrochloride, etc.

[0034] Examples of the colorant include legal dyes such as Blue No. 1, Yellow No. 4, Red No. 202, and Green No. 3; mineral - based dyes such as ultramarine, fortified ultramarine, and navy blue; and titanium oxide, etc. Examples of the pH adjuster include malic acid, pyrophosphoric acid, citric acid, phosphoric acid, lactic acid, tartaric acid, glycerophosphoric acid, acetic acid, nitric acid, or chemically possible salts thereof, and sodium hydroxide, etc.

[0035] Examples of the chelating agent include edetic acid, sodium edetate, potassium edetate, phytic acid, etc. Examples of the active ingredients include vitamin E compounds such as dl-α-tocopherol acetate and tocopherol succinate; vitamin C compounds such as ascorbic acid, sodium ascorbate, or magnesium ascorbyl phosphate; vitamin B6 compounds such as pyridoxine hydrochloride; glycyrrhizinate and its derivatives, glycyrrhetinic acid, amphoteric bactericides such as dodecyldiaminoethyl glycine; nonionic bactericides such as triclosan, isopropylmethylphenol, and polyoxyethylene lauryl ether; anionic bactericides such as sodium cocoyl sarcosinate and sorbic acid; cationic bactericides such as chlorhexidine hydrochloride, chlorhexidine gluconate, benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride; enzymes such as dextranase, amylase, protease, mutanase, lysozyme, and lysing enzyme (lytech enzyme); alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate; sodium fluoride, fluorine compounds other than specific fluorine compounds, tranexamic acid and epsilon-aminocaproic acid, aluminum chlorhydroxyl allantoin, dihydrocholesterol, hinokitiol, sodium copper chlorophyllin, chlorophyll, sodium chloride, caropeptide, allantoin, carbazochrom, potassium nitrate, and paratinit, etc.

[0036] Examples of the bases include alcohols, silicon, apatite, white petrolatum, paraffin, liquid paraffin, microcrystalline wax, squalane, and plastic base, etc.

[0037] Examples of the alcohols include ethyl alcohol, lauryl alcohol, and myristyl alcohol, etc. Examples of the abrasive include calcium carbonate, magnesium carbonate, dicalcium phosphate, tricalcium phosphate, magnesium phosphate, zeolite, sodium metaphosphate, aluminum hydroxide, magnesium hydroxide, red iron oxide, calcium sulfate, calcium hydrogen phosphate dihydrate and anhydride, calcium pyrophosphate, alumina, hydroxyapatite, aluminum silicate, zirconium silicate, calcium silicate, polymethyl methacrylate, pumice, bentonite, synthetic resin, and the like.

[0038] Examples of the stabilizer include sodium thiosulfate, sodium sulfite, calcium lactate, lanolin, triacetin, castor oil, magnesium sulfate, and the like. (Fluoride concentration) The fluoride concentration of the oral composition is 0.005% by mass (50 ppm) or more, preferably 0.01% by mass (100 ppm) or more, and more preferably 0.05% by mass (500 ppm) or more. Also, the fluoride concentration of the oral composition is 0.2% by mass (2000 ppm) or less, preferably 0.16% by mass (1600 ppm) or less, and more preferably 0.15% by mass (1500 ppm) or less. Further, an example of the fluoride concentration of the oral composition is 0.1% by mass (1000 ppm) or less, or 0.05% by mass (500 ppm) or less.

[0039] The upper limit or lower limit of the fluoride concentration of the oral composition may be 80 ppm, 100 ppm, 150 ppm, 200 ppm, 250 ppm, 300 ppm, 350 ppm, 400 ppm, 450 ppm, 500 ppm, 550 ppm, 600 ppm, 650 ppm, 700 ppm, 750 ppm, 800 ppm, 850 ppm, 900 ppm, 950 ppm, 1000 ppm, 1050 ppm, 1100 ppm, 1150 ppm, 1200 ppm, 1250 ppm, 1300 ppm, 1350 ppm, 1400 ppm, 1450 ppm, 1500 ppm, 1550 ppm, 1600 ppm, 1650 ppm, 1700 ppm, 1750 ppm, 1800 ppm, 1850 ppm, 1900 ppm, or 1950 ppm.

[0040] The above fluorine concentration is the fluorine concentration based on the compounding amount of the fluorine compound contained in the oral composition. Therefore, when the oral composition does not contain a fluorine compound other than the specific fluorine compound, the above fluorine concentration is the concentration of fluorine derived from the specific fluorine compound. When the oral composition contains other fluorine compounds other than the specific fluorine compound, the above fluorine concentration is the total of the concentration of fluorine derived from the specific fluorine compound and the concentration of fluorine derived from the other fluorine compounds. In the latter case, the ratio of the concentration of fluorine derived from the specific fluorine compound in the above fluorine concentration is, for example, 90% or more, 95% or more, or 99% or more.

[0041] (Blending amounts of components A to D) (A) The compounding amount of the specific fluorine compound is adjusted so that the fluorine concentration in the oral composition falls within the above range. For example, when the specific fluorine compound is sodium fluoride, the compounding amount of the specific fluorine compound is 0.01% by mass or more and 0.44% by mass or less. When the specific fluorine compound is sodium monofluorophosphate, the compounding amount of the specific fluorine compound is 0.04% by mass or more and 1.52% by mass or less. When the specific fluorine compound is stannous fluoride, the compounding amount of the specific fluorine compound is 0.02% by mass or more and 0.82% by mass or less.

[0042] (B) The compounding amount of lauroyl glutamate is, for example, 0.01% by mass or more, preferably 0.1% by mass or more. The compounding amount of lauroyl glutamate is, for example, 5% by mass or less, preferably 2% by mass or less.

[0043] The upper limit value or the lower limit value of the blending amount of lauroyl glutamate may be, for example, 0.02% by mass, 0.04% by mass, 0.06% by mass, 0.08% by mass, 0.1% by mass, 0.15% by mass, 0.2% by mass, 0.25% by mass, 0.3% by mass, 0.35% by mass, 0.4% by mass, 0.45% by mass, 0.5% by mass, 0.55% by mass, 0.6% by mass, 0.65% by mass, 0.7% by mass, 0.75% by mass, 0.8% by mass, 0.85% by mass, 0.9% by mass, 0.95% by mass, 1.0% by mass, 1.2% by mass, 1.4% by mass, 1.6% by mass, 1.8% by mass, 2.0% by mass, 2.2% by mass, 2.4% by mass, 2.6% by mass, 2.8% by mass, 3.0% by mass, 3.2% by mass, 3.4% by mass, 3.6% by mass, 3.8% by mass, 4.0% by mass, 4.2% by mass, 4.4% by mass, 4.6% by mass, or 4.8% by mass.

[0044] The ratio of the blending amount of lauroyl glutamate to the blending amount of the specific fluorine compound (lauroyl glutamate / specific fluorine compound) is, for example, 0.006 or more, preferably 0.008 or more. Also, the above-mentioned ratio of the blending amount is, for example, 500 or less, preferably 250 or less.

[0045] (C) The blending amount of the nicotinic acid compound is, for example, 0.01% by mass or more, preferably 0.1% by mass or more. Also, the blending amount of the nicotinic acid compound is, for example, 5% by mass or less, preferably 2% by mass or less.

[0046] The upper limit or lower limit of the blending amount of the nicotinic acid compound may be 0.02% by mass, 0.04% by mass, 0.06% by mass, 0.08% by mass, 0.1% by mass, 0.15% by mass, 0.2% by mass, 0.25% by mass, 0.3% by mass, 0.35% by mass, 0.4% by mass, 0.45% by mass, 0.5% by mass, 0.55% by mass, 0.6% by mass, 0.65% by mass, 0.7% by mass, 0.75% by mass, 0.8% by mass, 0.85% by mass, 0.9% by mass, 0.95% by mass, 1.0% by mass, 1.2% by mass, 1.4% by mass, 1.6% by mass, 1.8% by mass, 2.0% by mass, 2.2% by mass, 2.4% by mass, 2.6% by mass, 2.8% by mass, 3.0% by mass, 3.2% by mass, 3.4% by mass, 3.6% by mass, 3.8% by mass, 4.0% by mass, 4.2% by mass, 4.4% by mass, 4.6% by mass, or 4.8% by mass.

[0047] The ratio of the blending amount of the nicotinic acid compound to the blending amount of the specific fluorine compound (nicotinic acid compound / specific fluorine compound) is, for example, 0.006 or more, preferably 0.008 or more. Also, the above ratio of the blending amount is, for example, 500 or less, preferably 250 or less.

[0048] The ratio of the total of the blending amount of (B) lauroyl glutamate and the blending amount of (C) nicotinic acid compound to the fluorine concentration (total of the blending amount / fluorine concentration) is, for example, 0.1 or more, preferably 0.125 or more. Also, the above ratio of the total of the blending amount is, for example, 2000 or less, preferably 1000 or less.

[0049] (D) The blending amount of abrasive silica is, for example, 0.75% by mass or more, preferably 1.5% by mass or more. Also, the blending amount of abrasive silica is, for example, 50% by mass or less, preferably 30% by mass or less.

[0050] The upper limit or lower limit of the blending amount of abrasive silica may be 1% by mass, 2% by mass, 3% by mass, 4% by mass, 5% by mass, 6% by mass, 7% by mass, 8% by mass, 9% by mass, 10% by mass, 12% by mass, 14% by mass, 16% by mass, 18% by mass, 20% by mass, 25% by mass, 30% by mass, 35% by mass, 40% by mass, or 45% by mass.

[0051] The blending amount of abrasive silica is adjusted so that the ratio of the abrasive silica to the fluorine concentration in the oral composition (abrasive silica / specific fluorine compound) falls within a specific range. Hereinafter, the ratio of the blending amount of abrasive silica to the fluorine concentration in the oral composition will be referred to as the specific ratio. The above specific ratio is 150 or more, preferably 160 or more, more preferably 170 or more. Further, the above ratio is, for example, 10000 or less.

[0052] (Application form and uses) The application form of the oral composition is not particularly limited, and for example, it can be used as a pharmaceutical, quasi-drug, or cosmetic.

[0053] Examples of the uses of the oral composition include chewing agents, orally dissolving agents, orally disintegrating agents, tongue care agents, oral refreshing agents, mouthwashes, gargles, toothpastes, bad breath preventives, gingiva massagers, oral wetting agents, tongue coating removers, oral coating agents, oral bactericides, throat bactericides, oral and throat agents, periodontal disease treatment agents, denture coating agents, denture stabilizers, denture preservatives, denture cleaners, implant care agents, and the like.

[0054] <Oral composition in a container> The oral composition in a container includes an oral composition and a container for containing the oral composition. The oral composition is the oral composition described in the <Oral composition> column.

[0055] (Container) The container is, for example, a tube container made of polyethylene. The tube container made of polyethylene may have a portion made of polyethylene, and may be entirely made of polyethylene, or may have a portion made of polyethylene and a portion made of a material other than polyethylene. Note that the container may be a container that does not contain a portion made of polyethylene. Further, the shape of the container is not limited to a tube.

[0056] The container is made of, for example, a material that transmits ultraviolet rays. The ultraviolet transmittance of the container is, for example, 5% or more, 10% or more, 50% or more, 90% or more, or 95% or more. Examples of the container include the tube container described in Japanese Patent No. 6758955. An example of the tube container is a laminated tube container having a shoulder made of high-density polyethylene (HDPE). The laminated tube container is made of a composite material obtained by bonding sheets of different materials. Examples of the laminated tube container include those having a laminated structure throughout except for the cap portion, and those using a member for joining the main body portion (barrel portion) formed of a cap called a "shoulder" and a laminated sheet.

[0057] As the material of the shoulder, generally, polyethylene resin, polyolefin resins such as polypropylene, and polyester resins such as polyethylene terephthalate are used. An example of the laminated tube container has a shoulder made of, for example, high-density polyethylene (HDPE). The HDPE used has a density of 940 to 970 kg / m 3 , preferably 950 to 965 kg / m 3 , more preferably 953 to 960 kg / m 3 is used.

[0058] Note that the shoulder may contain a filler. A filler means a substance blended with a polyethylene resin for the purpose of imparting coloring, light-shielding properties, or improving mechanical strength. Examples of the filler include calcium carbonate, silica, talc, clay, mica, glass, titanium oxide, potassium titanate, zinc oxide, iron oxide, zeolite, pigment, and ultraviolet absorber. The filler usually has a shape such as fiber, flake, or granular, and those having a maximum diameter of 100 nm to several hundred μm, preferably 10 to 100 μm are used. The blending amount of the filler is, for example, 0.1 to 40% by mass, preferably 0.2 to 30% by mass, more preferably 0.3 to 20% by mass, still more preferably 0.4 to 10% by mass, and most preferably 0.5 to 8% by mass based on the total amount of the resin.

[0059] As a method for adding a filler to HDPE, known methods such as the masterbatch method, the kneading method, and the dry blend method can be used. Specific forms of the laminated tube container include, for example, those having a tubular body portion, a substantially frustoconical shoulder portion connected to one end of the body portion, and a spout portion connected to the shoulder portion. The end portion of the body portion opposite to the shoulder portion is open until the paste-like composition is filled, and is closed by a known method (for example, heat sealing) after the filling of the paste-like composition.

[0060] The laminate constituting the body portion is a sheet-like composite material obtained by laminating a plurality of substances in layers. The laminate can be manufactured using known methods such as the dry method, the extrusion method, the hot melt method, and the thermal method. The materials constituting the laminate are not particularly limited. Examples of the materials constituting the laminate include polyethylene (LDPE, MDPE, HDPE, LLDPE, metallocene polyethylene, ionomer polyethylene, etc.), nylon, polypropylene (CPP, OPP), ethylene-vinyl acetate copolymer (EVA), ethylene-acrylic copolymer (EAA), ethylene-methacrylic acid copolymer (EMAA), polyester, polystyrene, polyvinyl alcohol, polyvinylidene chloride, polyacrylonitrile, and aluminum (including vapor deposition).

[0061] The laminated structure of the laminate can be configured by combining layers made of the above materials. An example of the laminated structure is described as "inner / middle layer / outer layer" in the order from the inside to the outside with the surface in contact with the paste-like composition as the inside, and is a laminated structure represented by LLDPE (linear low-density polyethylene) / EAA / FOIL (aluminum foil) / EAA / LDPE (low-density polyethylene) / HDPE / LDPE. Regarding aluminum, it can be used not only in the form of aluminum foil but also by a method of vapor-depositing aluminum on the surface of other substances.

[0062] <Actions and Effects> Next, the actions and effects of the present embodiment will be described. (1) The oral composition contains at least one specific fluorine compound selected from sodium fluoride, sodium monofluorophosphate, and stannous fluoride, lauroyl glutamate, at least one nicotinic acid compound selected from nicotinic acid, nicotinic acid salts, and nicotinic acid derivatives, abrasive silica, and water. The fluorine concentration in the oral composition is 0.005% by mass or more and 0.2% by mass or less. The blending amount of the abrasive silica is 0.75% by mass or more and 50% by mass or less. The ratio of the blending amount of the abrasive silica to the fluorine concentration (blending amount of abrasive silica / fluorine concentration) is 150 or more.

[0063] When the oral composition containing the specific fluorine compound, lauroyl glutamate, and the nicotinic acid compound is left outdoors for a long period (for example, 30 days or more) in a container, the specific fluorine compound becomes non-uniform. According to the oral composition having the above configuration, since the abrasive silica is blended in an amount corresponding to a specific ratio with respect to the fluorine concentration, the non-uniformity of the above-described specific fluorine compound can be suppressed.

[0064] (2) The blending amount of the specific fluorine compound is 0.01% by mass or more and 1.52% by mass or less. The blending amount of lauroyl glutamate is 0.01% by mass or more and 5% by mass or less. The blending amount of the nicotinic acid compound is 0.01% by mass or more and 5% by mass or less. The oral composition having the above composition is likely to cause non-uniformity of the above-described specific fluorine compound. Therefore, when a configuration in which the abrasive silica is blended in a specific ratio is adopted for the oral composition having the above composition, the effect of suppressing the non-uniformity of the specific fluorine compound can be obtained more significantly.

[0065] (3) The ratio of the total blending amount of lauroyl glutamate and the nicotinic acid compound to the fluorine concentration (total blending amount / fluorine concentration) is 0.1 or more and 2000 or less. The oral composition having the above composition is likely to cause non-uniformity of the above-described specific fluorine compound. Therefore, when a configuration in which the abrasive silica is blended in a specific ratio is adopted for the oral composition having the above composition, the effect of suppressing the non-uniformity of the specific fluorine compound can be obtained more significantly.

[0066] (4) The viscosity of the oral composition is 50 Pa·s or more and 300 Pa·s or less. For the oral composition with the above viscosity, the above-mentioned specific fluorine compound is likely to be non-uniform. Therefore, when a configuration is adopted in which abrasive silica is blended in a specific ratio with respect to the oral composition with the above viscosity, the effect of suppressing the non-uniformity of the specific fluorine compound can be obtained more remarkably.

[0067] (5) The average particle diameter of the abrasive silica is 0.5 μm or more and 50 μm or less. In this case, the effect of suppressing the non-uniformity of the specific fluorine compound can be obtained more remarkably by blending the abrasive silica in a specific ratio.

[0068] (6) The oral composition in a container includes the oral composition and a container for accommodating the oral composition. The container is a container made of polyethylene. For the oral composition accommodated in the container with the above configuration, the above-mentioned specific fluorine compound is likely to be non-uniform. Therefore, when a configuration is adopted in which abrasive silica is blended in a specific ratio with respect to the oral composition accommodated in the above container, the effect of suppressing the non-uniformity of the specific fluorine compound can be obtained more remarkably.

Examples

[0069] The oral composition of this embodiment will be described in more detail based on the following examples. Note that the oral composition is not limited to the configuration described in the example column. (Preparation of Comparative Examples 1 to 3 and Examples 1 to 5) By mixing the components shown in Table 1, paste-like compositions of Comparative Examples 1 to 3 and Examples 1 to 5 were prepared. The unit of the numerical values in each component column of Table 1 is mass%. "POE" in Table 1 means "polyoxyethylene". The viscosity of the paste-like composition of each obtained example was measured. The results are shown in Table 1. Also, the fluorine concentration and specific ratio calculated from the composition of each example are shown in Table 1.

[0070] (Long-term storage test) For each paste composition, 25 g of the paste composition was enclosed in a polyethylene tube container and left outdoors for 2 months or 3 months. The test was carried out in summer when the temperature changes between 20 °C and 40 °C. As the tube container, a container having a tubular body portion, a shoulder portion having a cap portion at one end of the body portion, and a spout portion connected to the shoulder portion was used. The paste composition was filled from the end of the body portion opposite to the shoulder portion. After filling, the tube container was sealed by heat-sealing the end of the body portion opposite to the shoulder portion.

[0071] For the body portion of the tube container, with the surface in contact with the paste composition as the inner side, when the laminated structure is described as "inner / middle layer / outer" in the order from the inner side to the outer side, a laminated structure represented by LLDPE (linear low density polyethylene) / EAA (ethylene-acrylic acid copolymer) / FOIL (aluminum foil) / EAA / LDPE (low density polyethylene) / HDPE / LDPE was used.

[0072] After the above period elapsed, 1 g of the paste composition was extruded from the spout portion of the tube container, and a specimen was collected from the extruded paste composition. By repeating the extrusion of the paste composition from the tube container and the collection of the specimen 5 times, 5 specimens were obtained. For each specimen, after suspending the specimen (1 g) in water (100 mL), a solid-liquid separation treatment was performed. Next, the fluorine concentration in the recovered liquid was measured using a fluorine ion meter (manufactured by Thermo Fisher Scientific). For the 5 specimens collected from the same tube container, the relative standard deviation of the measured fluorine concentrations was calculated. Specifically, the relative standard deviation (%) was calculated by multiplying the value obtained by dividing the "standard deviation of the measured values of the fluorine concentrations of the 5 specimens" by the "average value of the measured values of the fluorine concentrations of the 5 specimens" by 100. The results are shown in Table 1. Hereinafter, the relative standard deviation of the fluorine concentration will be referred to as the RSD value.

[0073]

Table 1

[0074] On the other hand, Comparative Example 1 containing a specific fluorine compound and not containing lauroyl glutamate and a nicotinic acid compound has an RSD value of 0.3, which is a value close to 0. This result indicates that in the paste composition within the tube container, the specific fluorine compound is present uniformly, that is, the specific fluorine compound is not homogenized. From the results of Comparative Examples 1 to 3, it can be seen that the homogenization of the above specific fluorine compound is a phenomenon that occurs when lauroyl glutamate and a nicotinic acid compound are simultaneously contained.

[0075] Also, although detailed test data is omitted, for the paste composition of Comparative Example 2, a long-term storage test was conducted in the same manner as above, except that it was left indoors, in a constant temperature room at 5°C, or in a constant temperature room at 55°C for 3 months. As a result, the RSD value when left indoors was 0.4, the RSD value when left in the constant temperature room at 5°C was 0.6, and the RSD value when left in the constant temperature room at 55°C was 0.2. From this result, it is suggested that the homogenization of the above specific fluorine compound is caused by one or both of the storage conditions including long-term sunlight exposure and the repetition of temperature changes such as morning and evening.

[0076] Examples 1 to 5 are examples containing a specific fluorine compound, lauroyl glutamate, and a nicotinic acid compound, and are different from Comparative Example 2 and Comparative Example 3 in that the blending amount of abrasive silica is large. Specifically, the specific ratios (the ratio of the blending amount of abrasive silica to the fluorine concentration) of Comparative Example 2 and Comparative Example 3 are 84.2 and 140.4, respectively, while the specific ratios of Examples 1 to 5 are 150 or more.

[0077] As shown in Table 1, the RSD values of Examples 1 to 5 where the specific ratio is 150 or more are in the range of 0.6 to 1.8, and are significantly lower compared to the RSD values of Comparative Example 2 and Comparative Example 3. In particular, when comparing Comparative Example 3 where the specific ratio is about 140 with Examples 1 to 3 where the specific ratio is about 160, the RSD values of Examples 1 to 3 have significantly decreased to 1 / 2 or less of the RSD value of Comparative Example 3. From this result, it can be seen that by adjusting the blending amount of abrasive silica so that the specific ratio becomes 150 or more, it is possible to suppress the non-uniformity of the specific fluorine compound that occurs when lauroyl glutamate and nicotinic acid compounds are simultaneously contained.

[0078] Also, when comparing Example 1 and Comparative Example 3, although the total blending amount of abrasive silica and thickening silica is larger in Comparative Example 3, the RSD value is lower in Example 1 where the blending amount of abrasive silica is larger. From this result, it can be seen that the effect of suppressing the non-uniformity of the specific fluorine compound is not an effect that can be obtained simply by increasing the blending amount of silica.

[0079] (Formulation Example) Hereinafter, Formulation Examples 1 to 4 of the oral composition of the present invention are shown in Table 2.

[0080]

Table 2

Claims

1. At least one specific fluorine compound selected from sodium fluoride, sodium monofluorophosphate, and stannous fluoride, lauroyl glutamate, at least one nicotinic acid compound selected from nicotinic acid, nicotinic acid salts, and nicotinic acid derivatives, abrasive silica, water, and the fluorine concentration is 0.005% by mass or more and 0.2% by mass or less, the blending amount of the abrasive silica is 0.75% by mass or more and 50% by mass or less, An oral composition in which the ratio of the blending amount of the abrasive silica to the fluorine concentration (blending amount of abrasive silica / fluorine concentration) is 150 or more.

2. The blending amount of the specific fluorine compound is 0.01% by mass or more and 1.52% by mass or less, The blending amount of the lauroyl glutamate is 0.01% by mass or more and 5% by mass or less, The oral composition according to claim 1, wherein the blending amount of the nicotinic acid compound is 0.01% by mass or more and 5% by mass or less.

3. The oral composition according to claim 1, wherein the ratio of the total blending amount of the lauroyl glutamate and the nicotinic acid compound to the fluorine concentration (total blending amount / fluorine concentration) is 0.1 or more and 2000 or less.

4. The oral composition according to claim 1, having a viscosity of 50 Pa·s or more and 300 Pa·s or less.

5. The oral composition according to claim 1, wherein the average particle diameter of the abrasive silica is 0.5 μm or more and 50 μm or less.

6. An oral composition according to any one of claims 1 to 5, and a container for containing the oral composition, wherein the container is a container made of polyethylene.

Images