Flask tray, flask unit and cell culture system
The flask tray design with leaf spring and ring spring mechanisms provides stable and easy handling of flasks in cell culture systems, addressing the issue of flask stability and ease of attachment/detachment.
Patent Information
- Application Number
- JP2023219592
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2023-12-26
- Publication Date
- 2025-07-08
AI Technical Summary
Flasks used in cell culture systems are prone to falling over, hindering transportation and operations, and there is a need for easy attachment and detachment from the tray.
A flask tray design featuring a mounting plate with leaf spring portions and a ring spring to securely hold the flask, along with a frame and support column structure for stable placement and easy handling.
The design allows for stable holding and easy attachment/detachment of flasks, improving handleability and reducing the risk of contamination while enhancing assembly efficiency and maintainability.
Smart Images

Figure 2025102257000001_ABST
Abstract
Description
Technical Field
[0001] The present disclosure relates to a flask tray, a flask unit, and a cell culture system.
Background Art
[0002] Patent Document 1 discloses a culture vessel set having recesses capable of holding a plurality of case-shaped culture vessels containing a culture solution. The culture vessel set is used in a cell culture system for performing cell culture unmanned and automatically.
Prior Art Documents
Patent Documents
[0003]
Patent Document 1
Summary of the Invention
Problems to be Solved by the Invention
[0004] By the way, when performing cell culture, a flask may be used as a container for containing a culture solution. When such a flask is handled in a cell culture system, if the flask falls over, the transportation and each operation of the flask will be hindered. On the other hand, from the viewpoint of the handleability of the flask, it is preferable that the flask can be easily attached to and detached from the flask tray.
[0005] The present disclosure has been made to solve the above problems, and an object thereof is to provide a flask tray, a flask unit, and a cell culture system that can stably hold a flask and can easily attach and detach the flask.
Means for Solving the Problems
[0006] In order to solve the above problems, the flask tray according to the present disclosure includes a mounting plate having a mounting surface on which a flask with a flask body extending in the vertical direction around an axis and a lid portion fastened to the mouth of the flask body is placed, a plurality of leaf spring portions provided in the circumferential direction of the axis so as to extend upward from the mounting surface and capable of pressing the flask body inward in the radial direction of the axis, and a ring spring extending in the circumferential direction across the plurality of leaf spring portions and clamping the flask body from the outer peripheral side. It is provided with.
[0007] The flask tray according to the present disclosure includes a mounting plate having a mounting surface on which a flask with a flask body extending in the vertical direction around an axis and a lid portion fastened to the mouth of the flask body is placed, a support column extending upward from the mounting plate, and a frame supported by the support column above the mounting plate and surrounding the flask in the horizontal direction so that the flask can be placed on the mounting surface from above. The frame has a lid placement portion capable of holding the lid portion. The lid placement portion has a hole penetrating the frame in the vertical direction and having an inner diameter into which the lower portion of the lid portion can be inserted, and a plurality of convex portions protruding from the inner peripheral surface of the hole and provided in the circumferential direction.
[0008] The flask tray according to the present disclosure includes a placement plate having a placement surface on which the flask is placed, a support column extending upward from the placement plate, and a frame that is supported by the support column above the placement plate and surrounds the flask from the horizontal direction so that the flask can be placed on the placement surface from above. The support column has a columnar support column body extending in the vertical direction, a lower screw shaft protruding from the lower end of the support column body, and an upper screw hole recessed from the upper end of the support column body. The placement plate has a lower screw hole that is recessed from the placement surface and into which the lower screw shaft can be fastened, and an insertion recess into which the lower end of the support column body is inserted and fitted from above. The frame has an outer fitting recess that is externally fitted to the upper end of the support column body from above, and a screw insertion hole that penetrates the frame in the vertical direction. The upper screw that fixes the support column and the frame by being inserted into the screw insertion hole from above and fastened to the upper screw hole is further provided.
[0009] The flask unit according to the present disclosure includes the above-described flask tray and the flask.
[0010] The cell culture system according to the present disclosure includes the above-described flask unit, a stocker that forms a storage area for storing the flask unit, an incubator that forms a culture area for performing a culture operation on the flask unit, a clean bench that forms a liquid operation area for performing a dispensing operation on the flask unit, and a transport device that transports the flask unit across the stocker, the incubator, and the clean bench.
Effects of the Invention
[0011] According to the present disclosure, the flask can be stably held and can be easily attached and detached.
Brief Description of the Drawings
[0012]
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Mode for Carrying Out the Invention
[0013] <First Embodiment> Hereinafter, embodiments of the present disclosure will be described in detail with reference to the drawings. As shown in FIG. 1, the cell culture system 100 of the present embodiment is a system that performs cell culture, analysis of cells after culture, etc., using a flask unit 1 (see FIG. 2) as a work as a processing unit, and these processes are performed, for example, unmanned and automatically.
[0014] As shown in FIGS. 2 and 3, the flask unit 1 has a plurality (for example, two in the present embodiment) of flasks 2. A culture solution containing cells and a medium supplemented with nutrients necessary for cell growth is accommodated in the flask 2.
[0015] <Cell Culture System> As shown in FIG. 1, the cell culture system 100 has a first stocker 110 and a second stocker 120 as stockers, an incubator 130, a clean bench 140, and a pass box 150.
[0016] <First Stocker> The stocker is a facility for storing a plurality of flask units 1 and other workpieces. The area inside the stocker is defined as the first storage area R1. The storage area is provided with racks capable of accommodating a large number of workpieces. An operator can access the racks from the outside through an opening / closing part (not shown).
[0017] <Second stocker> The second stocker 120 is provided adjacent to the first stocker 110. The second stocker 120 is provided with facilities such as a pedestal on which the workpiece can be placed so that the workpiece can be directly loaded into the clean bench 140 manually, and a refrigerated freezer capable of storing the culture solution in a frozen state so that the cells can be operated as needed.
[0018] <Incubator> The incubator 130 is a facility for growing cells in a culture solution. The area inside the incubator 130 is defined as the culture area R3. The atmosphere in the culture area R3 is controlled to a temperature, humidity, and carbon dioxide concentration suitable for cell culture. The culture area R3 is provided with a shaking stage capable of shaking a plurality of flask units 1 simultaneously.
[0019] <Clean bench> The clean bench 140 is a facility for performing various liquid operations and treatments on the flask unit 1. The area inside the clean bench 140 is defined as the liquid operation area R4. The liquid operation area R4 is a highly clean aseptic space (bio clean room).
[0020] Inside the clean bench 140, various facilities such as a dispensing device, a filtering device, a sealing device, a waste liquid draining device, and a workpiece discharging device are provided. Outside the clean bench 140, a medium supply device capable of supplying a medium to the dispensing device, a cell analysis device capable of analyzing the culture solution dispensed by the dispensing device, etc. are provided.
[0021] Here, the clean bench 140 is arranged adjacent to the first stocker 110 and the second stocker 120. Inside the first stocker 110, a first stocker door 110a is provided that separates the first storage area R1 and the liquid operation area R4. When the first stocker door 110a is in the open state, the first storage area R1 and the liquid operation area R4 are in a communicating state, and workpieces can move back and forth between these areas. When the first stocker door 110a is in the closed state, the first storage area and the liquid operation area R4 are in a non-communicating state, and these areas are isolated.
[0022] Inside the second stocker 120, a second stocker door 120a is provided that separates the second storage area R2 and the liquid operation area R4. When the second stocker door 120a is in the open state, the second storage area R2 and the liquid operation area R4 are in a communicating state, and workpieces can move back and forth between these areas. When the second stocker door 120a is in the closed state, the second storage area R2 and the liquid operation area R4 are in a non-communicating state, and these areas are isolated.
[0023] <Passbox> The passbox 150 is provided between the incubator 130 and the clean bench 140 in contact with them. The passbox 150 has a first pass door 150a and a second pass door 150b. When the first pass door 150a is in the open state, the culture area R3 and the area inside the passbox 150 are in a communicating state. When the second pass door 150b is in the open state, the liquid operation area R4 and the area inside the passbox 150 are in a communicating state. Therefore, by the opening and closing operations of these first pass door 150a and second pass door 150b, the state of being isolated and the state where workpieces can move back and forth are switched between the culture area R3 and the liquid operation area R4. Note that the first pass door 150a and the second pass door 150b are not in the open state at the same time. Thus, the culture area R3 and the liquid operation area R4 do not communicate with each other, and the atmospheric state of each area is maintained.
[0024] <Conveyor device> In each of the first storage area R1, the second storage area R2, the culture area R3, and the liquid operation area R4, a transport robot movable in the horizontal direction, for example, is provided as a transport device. Thereby, the movement of the workpiece in each area is enabled. By the cooperation of the opening and closing of each door and the operation of the transport robot, the workpiece can move back and forth in each area.
[0025] <Detailed Structure of the Flask Unit> Next, the detailed structure of the flask unit 1 equipped with the flask 2 will be described with reference to FIGS. 2 to 7. The flask unit 1 is composed of a flask 2 and a flask tray 10.
[0026] <Flask> In this embodiment, an Erlenmeyer flask with a lid is adopted as the flask 2. The flask 2 has a flask body 3 and a lid portion 7.
[0027] <Flask Body> The flask body 3 is a so-called Erlenmeyer flask. As shown in FIGS. 2 and 4, the flask body 3 has a bottomed cylindrical shape centered on a first axis O1 extending in the vertical direction V, and the upper part is open. The first axis O1 is the central axis of the flask 2. The bottom surface 4 of the flask body 3 is circular in plan view centered on the first axis O1. The outer peripheral surface 5 of the flask body 3 is provided so as to rise upward from the outer peripheral edge of the bottom surface 4. The outer peripheral surface 5 of the flask body 3 has a conical surface shape centered on the first axis O1 whose diameter decreases upward. The upper part of the flask body 3 is provided with a cylindrical mouth portion 6 that is continuous with the upper end of the outer peripheral surface 5 of the flask 2 and centered on the first axis O1. A male screw that twists around the first axis O1 is formed on the outer peripheral surface 5 of the mouth portion 6.
[0028] <Lid Portion> The lid portion 7 has a bottomed cylindrical shape with an end face at the upper end. A slit and a filter as openings are provided at the upper end of the lid portion. When the lid portion 7 is attached to the flask body 3, it extends in the vertical direction V around the first axis O1. The outer shape of the cross-section (horizontal cross-section) orthogonal to the first axis O1 of the lid portion 7 is circular. A female screw that twists around the first axis O1 is formed on the inner peripheral surface of the lid portion 7. By screwing the female screw of the lid portion 7 into the male screw of the mouth portion 6, the lid portion 7 is attached to the flask body 3. This prevents contamination from above into the flask body. The lid portion 7 is configured to be attachable and detachable to / from the flask body 3 by relatively rotating it around the first axis O1 with respect to the flask body 3. In the present embodiment, the clockwise rotation in a plan view is defined as the attachment direction of the lid portion 7, and the counterclockwise rotation in a plan view is defined as the detachment direction of the lid portion 7.
[0029] <Flask Tray> With the two flasks 2 as a set, various operations and transports are performed while the flasks 2 are placed on the flask tray 10. As shown in FIG. 2, the flask tray 10 includes a placement plate 20, a fixing structure 30, a support column 40, and a frame 50.
[0030] <Placement Plate> The placement plate 20 is a member on which the flask 2 is placed. The placement plate 20 has a flat plate shape extending in the horizontal direction, which is a direction orthogonal to the vertical direction V. The placement plate 20 has a rectangular shape in a plan view. Hereinafter, the short side direction of the placement plate 20 in a plan view is referred to as the first direction D1. The second direction D2 of the placement plate 20 in a plan view is referred to.
[0031] The upper surface of the mounting plate 20 is a mounting surface 21 on which the flask 2 is mounted. The lower surface of the mounting plate 20 is a back surface 22 that is mounted on a stage 160 (see FIG. 7) on various facilities of the cell culture system 100. The flasks 2 are arranged in a plurality (two in this embodiment) in the second direction D2 with the bottom surface 4 of the flask 2 in contact with the mounting plate 20. In other words, the arrangement direction of the plurality of flasks 2 coincides with the second direction D2. The plurality of flask bodies 3 are provided at a position biased to one side in the first direction D1 on the mounting plate 20.
[0032] As shown in FIGS. 2 and 7, the mounting plate 20 is formed with a plurality of positioning holes 23 that penetrate the mounting plate 20 vertically. The positioning holes 23 are provided in a pair spaced apart in the second direction D2 at a position biased to the other side in the first direction D1 of the mounting plate 20. One of the pair of positioning holes 23 is a first hole portion 23a that forms a perfect circle in plan view. The other of the pair of positioning holes 23 is a second hole portion 23b that forms a long hole shape extending in the second direction D2 in plan view. Note that the first hole portion 23a does not necessarily have to be strictly circular. For example, it indicates that it is circular allowing for machining errors, machining roughness, etc. during hole drilling with a drill or reamer. Also, the first hole portion may be circular and closer to a perfect circle than the second hole portion that forms a long hole shape.
[0033] <Fixing structure> The fixing structure 30 is a structure for stably arranging the flask body 3 on the mounting surface 21 of the mounting plate 20. The fixing structures 30 are provided in a plurality (two in this embodiment) spaced apart in the second direction D2 according to the arrangement location of the flasks 2. As shown in FIGS. 3 and 4, each fixing structure 30 includes a holding member 31, a mounting plate 32, a screw 33, an elastic ring 34, and a rotation preventing member 35.
[0034] <Holding member> A plurality (two in this embodiment) of holding members 31 are provided on each fixing member. The holding member 31 is composed of a member such as an elastically deformable metal or resin. The holding member 31 is formed by bending a long flat plate. The holding member 31 has a base plate portion 31a, a bent portion 31b, a pair of leaf spring portions 31c, and a pair of gripping portions 31d.
[0035] The base plate portion 31a is a portion that extends along a horizontal plane in the diameter direction of the first axis O1. As shown in FIG. 3, the base plate portion 31a extends so as to intersect the first axis O1 in a plan view. As shown in FIG. 4, the bent portion 31b is a plate-like portion provided at both ends in the extending direction of the base plate portion 31a. The bent portion 31b is smoothly connected so as to be continuous from both ends of the base plate portion 31a, and is formed so as to curve upward.
[0036] As shown in FIGS. 3 and 4, the leaf spring portion 31c is a flat plate-like portion connected to the upper ends of the pair of bent portions 31b. The leaf spring portion 31c is smoothly connected so as to be continuous with the bent portion 31b, and linearly extends so as to incline inward in the radial direction of the first axis O1 as it goes upward. The leaf spring portion 31c is elastically deformable in the radial direction of the first axis O1 with the bent portion 31b as a fulcrum. The plate surface of the leaf spring portion 31c facing the inner side in the radial direction of the first axis O1 is adapted to contact the outer peripheral surface 5 of the flask body 3.
[0037] By placing the flask body 3 on the placement surface 21, the outer peripheral surface 5 of the flask body 3 elastically deforms the leaf spring portion 31c radially outward. As a result, the plate surface of the leaf spring portion 31c presses the outer peripheral surface 5 of the flask body 3 with an elastic force.
[0038] The gripping portions 31d are respectively connected to the upper ends of the pair of leaf spring portions 31c. The gripping portions 31d are smoothly connected so as to be continuous with the upper ends of the leaf spring portions 31c. The gripping portions 31d are curved so as to warp outward in the radial direction of the first axis O1 from the upper ends of the leaf spring portions 31c, and the tips are in contact with the leaf spring portions 31c from the outside in the radial direction of the first axis O1. That is, the gripping portions 31d form a loop shape that forms a hollow portion inside. The hollow portion extends in the circumferential direction of the first axis O1 or extends in the tangential direction of a circle centered on the first axis O1.
[0039] As shown in FIG. 3, a plurality of such holding members 31 are arranged at angular displacements in the circumferential direction of the first axis O1 in each fixing structure 30. In the present embodiment, two holding members 31 are arranged so as to be angularly displaced by 90° in a plan view in each fixing structure 30. As a result, a total of four leaf spring portions 31c are configured to abut against and press the outer peripheral surface 5 of one flask body 3 from the outside in the radial direction of the first axis O1.
[0040] <Placement plate> The placement plate 32 is a member having a disk shape in a plan view, and is provided so as to be laminated on the placement surface 21 and the holding member 31 from above so that the center coincides with the first axis O1. That is, the base plate portion 31a of the holding member 31 is interposed between the placement plate 32 and the placement surface 21. The upper surface of the placement plate 32 is flat along a horizontal plane, and the bottom surface 4 of the flask body 3 is placed thereon. In the present embodiment, the flask body 3 is placed on the placement surface 21 of the placement plate 20 via the placement plate 32. A plurality of bent portions 31b of the holding member 31 are arranged at intervals in the circumferential direction on the outer peripheral side of the placement plate 32.
[0041] <Screw> The screw 33 fixes the mounting plate 32 and the holding member 31 to the mounting plate 20. As shown in FIG. 4, the screw 33 is a screw extending along the first axis O1, penetrating downward from the upper surface of the mounting plate 32 through the mounting plate 32, and also penetrating through the base plate portion 31a of the holding member 31. And the lower part of the screw 33 is fastened to the mounting plate 20. The screw 33 is fastened to the mounting plate 20 by being rotated clockwise in a plan view. The screw 33 is removed from the mounting plate 20 by being rotated counterclockwise in a plan view. That is, in the present embodiment, the clockwise direction in a plan view among the rotation directions of the screw 33 is defined as the fastening direction, and the counterclockwise direction in a plan view is defined as the removal direction.
[0042] <Elastic ring> The elastic ring 34 is an annular spring. The elastic ring 34 is configured such that an urging force is generated in the direction of reducing the diameter when the diameter is expanded by an external force. The elastic ring 34 has an annular shape formed by connecting both ends of, for example, a coil spring to each other. That is, the elastic ring 34 is formed by winding a metal wire into a toroidal shape. As the elastic ring 34, various configurations can be adopted as long as the configuration generates an urging force in the direction of reducing the diameter as described above.
[0043] The elastic ring 34 is arranged so as to surround the first axis O1. The elastic ring 34 is gripped by the gripping portions 31d of the holding member 31 at a plurality of locations in the circumferential direction. That is, the elastic ring 34 extends in the circumferential direction of the first axis O1 so as to pass through the hollow portions of the plurality of gripping portions 31d. Thereby, the elastic ring 34 is supported by the plurality of gripping portions 31d. By placing the flask body 3 on the placement surface 21, the elastic ring 34 is expanded in diameter. Thereby, the elastic ring 34 generates an urging force in the direction of reducing the diameter. That is, the elastic ring 34 contacts the outer peripheral surface 5 of the flask body 3 over the entire circumferential direction of the first axis O1 and clamps the outer peripheral surface 5.
[0044] <Anti-rotation member> As shown in FIGS. 3 and 4, the anti-rotation member 35 is fixed on the mounting surface 21 so as to abut against the holding member 31 from the circumferential direction of the first axis O1 on the outer peripheral side of the flask body 3. In the present embodiment, a pair of anti-rotation members 35 are arranged so as to sandwich one of the plurality of holding members 31 of each fixing structure 30 from both sides in the circumferential direction. The anti-rotation member 35 of the present embodiment is the head of a bolt fastened to the mounting plate 20. The anti-rotation member 35 is arranged to abut against one bent portion 31b of the holding member 31 from both sides in the circumferential direction of the first axis O1.
[0045] <Strut> The strut 40 is a rod-shaped member extending upward from the mounting surface 21. A plurality (four in the present embodiment) of struts 40 are provided. Each strut 40 is provided at four corner portions where the short side and the long side of the mounting plate 20 are connected in a plan view. The heights of the upper ends of the plurality of struts 40 are the same as each other.
[0046] <Frame> The frame 50 is supported by a plurality of struts 40 above the mounting plate 20. The frame 50, like the mounting plate 20, has a rectangular shape with the first direction D1 as the short side direction and the second direction D2 as the long side direction in a plan view. The contour shape of the frame 50 in a plan view is the same as that of the mounting plate 20. The upper-facing surface of the frame 50 is a flat frame upper surface 51. The lower-facing surface of the frame 50 is a flat frame lower surface 52. The upper ends of the struts 40 are connected to the frame lower surface 52. Thereby, the frame 50 is arranged above the mounting plate 20 so as to be parallel to the mounting plate 20.
[0047] The frame 50 is formed with an opening 55 that penetrates vertically. The opening 55 has a rectangular shape with the first direction D1 as the short side direction and the second direction D2 as the long side direction in a plan view. The opening 55 extends in the second direction D2 at a position biased to one side of the frame 50 in the first direction D1. The flask 2 placed on the placement surface 21 penetrates the opening 55 vertically. That is, the flask 2 on the placement surface 21 is surrounded by the frame 50 from all around in the horizontal direction.
[0048] <Connection Structure of the Placement Plate, Support Column, and Frame> Here, the connection structure of the placement plate 20, the support column 40, and the frame 50 will be described with reference to FIG. 5. The support column 40 has a support column body 41, a lower screw shaft 41a, and an upper screw hole 41b. The support column body 41 has a rod-shaped portion that extends in the vertical direction V. The central axis of the support column body 41 is defined as the second axis O2. The cross-sectional shape of the support column body 41 orthogonal to the second axis O2 is circular with the second axis O2 as the center. The lower end and the upper end of the support column body 41 are each made flat along a horizontal plane.
[0049] The lower screw shaft 41a is a portion that protrudes downward along the second axis O2 from the lower end of the support column body 41. The outer diameter of the lower screw shaft 41a is smaller than the outer diameter of the support column body 41. A male screw around the second axis O2 is formed on the outer peripheral surface 5 of the lower screw shaft 41a. The upper screw hole 41b is a portion that recesses downward along the second axis O2 from the upper end of the support column body 41. The inner diameter of the upper male screw hole is smaller than the outer diameter of the support column body 41. A female screw around the second axis O2 is formed on the inner peripheral surface of the upper screw hole 41b.
[0050] At the connection location with the support column 40 on the placement surface 21 of the placement plate 20, an insertion recess 24 that is recessed downward from the placement surface 21 is formed. The inner peripheral surface of the insertion recess 24 has the same shape as the cross-sectional shape orthogonal to the second axis O2 of the support column body 41 in a plan view. In the present embodiment, the shape of the inner peripheral surface of the insertion recess 24 in a plan view is circular. The insertion recess 24 is shaped such that the support column body 41 can be inserted from above. The bottom surface of the insertion recess 24 is flat along the horizontal plane. The lower end portion of the support column body 41 is fitted into the insertion recess 24. The lower end surface of the support column body 41 abuts against the bottom surface of the insertion recess 24 so as to contact it.
[0051] At the center of the bottom surface of the insertion recess 24 in the placement plate 20, a lower screw hole 25 that extends further downward from the bottom surface is formed. On the inner surface of the lower screw hole 25, a female screw capable of fastening the lower screw shaft 41a of the support column body 41 is formed.
[0052] At the connection location with the support column 40 on the frame lower surface 52 of the frame 50, an outer fitting recess 53 that is recessed upward from the placement surface 21 is formed. The inner peripheral surface of the outer fitting recess 53 has the same shape as the cross-sectional shape orthogonal to the second axis O2 of the support column body 41 in a plan view. In the present embodiment, the shape of the inner peripheral surface of the outer fitting recess 53 in a plan view is circular. The outer fitting recess 53 is shaped such that it can be externally fitted to the upper end portion of the support column body 41 from above. The top surface of the outer fitting recess 53 is flat along the horizontal plane. The upper end portion of the support column body 41 is fitted into the outer fitting recess 53. The upper end surface of the support column body 41 abuts against the top surface of the outer fitting recess 53 so as to contact it.
[0053] In the frame 50, a screw insertion hole 54 that penetrates the frame upper surface 51 and the top surface of the outer fitting recess 53 in the vertical direction V is formed. At least the upper inner peripheral surface of the screw insertion hole 54 is tapered such that the diameter decreases downward. The inner diameter of the opening location of the screw insertion hole 54 at the lower end to the top surface of the outer fitting recess 53 is smaller than that of the outer fitting recess 53.
[0054] In a state where the upper end portion of the support column 40 is fitted into the externally fitted concave portion 53 of the frame 50, the support column 40 is fixed integrally with the frame 50 by the upper screw 42. The upper screw 42 has a head portion 42a and an upper male screw shaft 42b. The head portion 42a is inserted into the screw insertion hole 54 in the frame 50 from above. The outer peripheral surface of the head portion 42a has a tapered shape that tapers downward, and is capable of being in close contact with the inner main surface of the screw insertion hole 54. The upper male screw shaft 42b is provided so as to extend downward from the lower end of the head portion 42a, and a male screw is formed on the outer peripheral surface. The upper male screw shaft 42b is inserted into and fastened to the upper screw hole 41b of the support column main body 41 fitted into the externally fitted concave portion 53 through the screw insertion hole 54.
[0055] <Carrying hole portion> On each of the edge portions on both sides in the first direction D1 of the frame 50, a pair of carrying hole portions 56 are formed so as to be separated in the second direction D2. The carrying hole portion 56 is a hole that penetrates the frame 50 in the vertical direction V. Claws of an arm of a carrying robot inserted from below are inserted into the carrying hole portion 56 along the edge portions on both sides in the first direction D1 of the frame 50 and below the edge portions. Thereby, it becomes possible to carry the flask unit 1 within the cell culture system 100.
[0056] <Lid placement portion> The lid placement portion 60 is a portion capable of holding the lid portion 7 removed from the flask body 3. Two lid placement portions 60 are provided at intervals in the second direction D2 in a region biased to the other side in the first direction D1 of the frame 50. The lid placement portion 60 of the present embodiment is constituted by a hole 61 and a convex portion 62 formed in the frame 50.
[0057] <Hole> As shown in FIGS. 3 and 6, the hole 61 is formed to penetrate vertically across the upper frame surface 51 and the lower frame surface 52 of the frame 50. The hole 61 is circular in plan view. That is, the hole 61 extends in the vertical direction V about a third axis O3 passing through the center of the circle in plan view. The inner diameter of the hole 61 is dimensioned to correspond to the outer diameter of the lid portion 7, and is set, for example, to be slightly larger than the outer diameter of the lid portion 7. Thereby, the hole 61 is configured to be able to insert the lid portion 7.
[0058] <Convex portion> The convex portion 62 is configured to protrude radially inward of the third axis O3 from the inner peripheral surface of the hole 61. A plurality of convex portions 62 are formed at intervals in the circumferential direction. In the present embodiment, a total of four convex portions 62 are formed at equal intervals in the circumferential direction. As shown in FIG. 6, the upper surface of the convex portion 62 is inclined downward as it goes radially inward of the third axis O3. The convex portion 62 has a tapered shape in which the circumferential dimension decreases as it goes radially inward.
[0059] <Function and effect> When attaching the flask 2 of the present embodiment to the flask tray 10, the bottom surface 4 of the flask body 3 is inserted by screwing it inside the elastic ring 34. At this time, the elastic ring 34 expands in diameter, and along with the expansion of the diameter of the elastic ring 34, the plurality of leaf spring portions 31c are elastically deformed radially outward of the first axis O1, respectively. Thereby, a passage for moving the flask 2 on the placement surface 21 is formed. When the bottom surface 4 of the flask body 3 is placed on the placement surface 21, the elastic ring 34 tends to contract in diameter according to the tapered surface shape of the outer peripheral surface 5 of the flask body 3, and further, the leaf spring portion 31c tends to return radially inward of the first axis O1.
[0060] The outer diameter position at the height where the elastic ring 34 and the leaf spring portion 31c contact on the outer peripheral surface 5 of the flask body 3 is located radially outside the position where the elastic ring 34 and the leaf spring portion 31c were initially located. Therefore, the elastic ring 34 and the leaf spring portion 31c are in a state of being located radially outside the first axis O1 compared to the position where they were initially located. As a result, the elastic ring 34 abuts against the outer peripheral surface 5 of the flask body 3 and holds it so as to clamp the outer peripheral surface 5. Further, the leaf spring portion 31c of the flask body 3 presses the flask body 3 toward the inside in the radial direction of the first axis O1. Thereby, the flask body 3 can be fixed by both the clamping force of the elastic ring 34 and the biasing force of the leaf spring portion 31c. Therefore, it is possible to hold the flask 2 more stably while suppressing the deviation of the posture of the flask 2.
[0061] When removing the flask 2 from the flask tray 10, the flask 2 is pulled upward from the flask tray 10. Then, the elastic ring 34 is elastically deformed so as to expand in diameter according to the tapered shape of the outer peripheral surface 5 of the flask body 3, and accordingly, the leaf spring portion 31c is elastically deformed radially outside the first axis O1. Thereby, a passage for moving the flask 2 upward is formed. As a result, the flask 2 can be easily removed from the flask tray 10.
[0062] As described above, according to the present embodiment, since the leaf spring portion 31c and the ring spring are each configured to elastically deform in the radial direction of the flask 2, the flask 2 can be easily placed on the flask tray 10 and removed from the flask tray 10.
[0063] Further, in the present embodiment, since the leaf spring portion 31c is formed in the holding member 31 and the holding member 31 is fixed on the mounting surface 21 with the screw 33, the leaf spring portion 31c can be easily arranged at a desired position.
[0064] When a dispensing operation is performed on the flask unit 1 by, for example, a dispensing device, the lid 7 is attached to and detached from the flask body 3. This attachment and detachment operation is performed by rotating the lid 7 around the first axis O1. At this time, the torque generated by the rotation will act on the holding member 31 via the flask body 3. If no countermeasures are taken here, the screw 33 that fixes the holding member 31 together with the holding member 31 will rotate due to the torque. As a result, the screw 33 may be tightly fastened or may become loose.
[0065] In contrast, in the present embodiment, a rotation prevention member 35 is provided so as to sandwich the holding member 31 from both sides in the circumferential direction of the first axis O1. Therefore, even if the holding member 31 tries to rotate, the rotation is restricted by the rotation prevention member 35 existing in the rotation direction. Therefore, the screw 33 does not rotate inadvertently.
[0066] Particularly in the present embodiment, by providing the rotation prevention member 35 on the side opposite to both the attachment direction of the lid 7 and the tightening direction of the screw 33 with respect to the holding member 31, it is possible to avoid the screw 33 becoming loose and falling off as a result. Therefore, the trouble of re-tightening the screw 33 can be saved, and the maintainability can be improved.
[0067] In addition, due to the presence of the mounting plate 20, it is possible to avoid the bottom of the flask body 3 coming into direct contact with the base plate portion 31a of the holding member 31. Thereby, damage such as the flask body 3 being scratched can be prevented. Furthermore, by appropriately adjusting the thickness of the mounting plate 20, the height of the mouth portion 6 of the flask body 3 can be arbitrarily changed. Thereby, the handleability of the flask 2 in various devices can be improved.
[0068] In addition, since the lid placement portion 60 is provided so as to correspond to the placement location of each flask body 3, the correspondence relationship between the flask body 3 and the lid portion 7 can be maintained. Therefore, it is possible to avoid misattachment between the flask body 3 and the lid portion 7 and prevent contamination. And by configuring the lid placement portion 60 with the hole 61 and the convex portion 62, for example, it is possible to suppress the liquid adhering to the lid portion 7 from staying in the lid placement portion 60. Therefore, hygiene can be ensured.
[0069] Also, when assembling the flask unit 1, the support column 40 may be inserted into the insertion recess 24 of the placement plate 20 from above and abutted, and further, the outer fitting recess 53 of the frame 50 may be externally fitted to the support column 40 from above and abutted. Thereby, the positioning accuracy of the placement plate 20, the support column 40, and the frame 50 can be increased, and assembly can be easily performed.
[0070] Furthermore, when assembling, the support column 40 may be accessed from above with respect to the placement plate 20, and further, the frame 50 may be accessed from above with respect to the support column 40, and then the upper screw 42 may be attached from above. By adopting a configuration in which all assembly is performed by access from above in this way, the work load can be reduced. Also, since there is no need to fasten screws from below, it is possible to avoid the screws from falling off below.
[0071] Here, when the flask unit 1 is arranged in various facilities of the cell culture system 100, it is necessary to position the flask unit 1 at an appropriate location. In contrast, in the present embodiment, for example, as shown in FIG. 7, positioning pins 161 are provided on the stages 160 of various facilities. Then, the positioning pins 161 enter the two positioning holes 23 of the placement plate 20, thereby positioning the flask unit 1.
[0072] At this time, in the present embodiment, since one of the first hole portion 23a and the second hole portion 23b as the positioning holes is in the shape of a long hole, the above positioning can be easily performed. That is, although it is necessary to fit two positioning holes into both of the two positioning pins 161 at the same time, since the second hole portion 23b is in the shape of a long hole, it is possible to give a likelihood corresponding to the formation range of the long hole. As a result, it becomes possible to position the flask unit 1 on the stage 160 while allowing assembly errors of the system and machining errors of parts. Further, if both the first hole portion 23a and the second hole portion 23b are in the shape of a long hole, the positioning accuracy cannot be ensured. However, since the first hole portion 23a is circular and closer to a perfect circle than the second hole portion 23b, the positioning accuracy can be ensured by the contribution of the first hole portion 23a.
[0073] <Other Embodiments> As described above, each embodiment of the present disclosure has been described in detail with reference to the drawings. However, the specific configuration is not limited to this embodiment, and design changes and the like within the scope not departing from the gist of the present disclosure are also included.
[0074] For example, as shown in FIG. 8, a tag reader 70 may be provided on the flask tray 10. The tag reader 70 has a support portion 71 and a tag reader main body 72. The support portion 71 is fixed to the lower surface 52 of the frame. The support portion 71 is provided at the center in the arrangement direction of the pair of flasks 2. Various information of the flask unit 1 is stored in the tag reader main body 72. The tag reader main body 72 is provided on the other side (the front side of the paper surface in FIG. 8) of the first direction D1 in the support portion 71. That is, the tag reader main body 72 faces the side opposite to the flask unit 1, that is, is arranged at a position accessible from the outside of the flask unit 1. Therefore, the reading process of the tag reader 70 can be easily performed.
[0075] Further, the tag reader 70 is arranged at an interval above the placement plate 20. For this reason, it is possible to avoid the visibility of the culture solution in the flask main body 3 being hindered by the presence of the tag reader 70.
[0076] In the embodiment, two holding members 31 are provided. However, only one holding member 31 may be provided, or three or more holding members 31 may be provided. In addition, each holding member 31 is configured such that leaf spring portions 31c and gripping portions 31d are provided at both ends of the base plate portion 31a. However, the present invention is not limited thereto. A configuration in which the leaf spring portions 31c and the gripping portions 31d are provided only at one end of the base plate portion 31a may also be used. The gripping portion 31d is not limited to the configuration of the embodiment, and various configurations can be adopted as long as it can support the elastic ring 34.
[0077] In the embodiment, the flask unit 1 on which two flasks 2 can be placed has been described. However, the present invention is not limited thereto. A configuration in which only one flask 2 or three or more flasks 2 can be placed may also be used. Note that the hole 61 of the lid placement portion 60 does not necessarily penetrate the frame 50. That is, the hole 61 may be formed as a recess that is recessed from above. Further, a small-diameter through portion that penetrates in the vertical direction V may be formed in the hole 61 as the recess, and a configuration for avoiding liquid retention through the through portion may also be used.
[0078] <Appendix> The flask tray 10, the flask unit 1, and the cell culture system 100 described in each embodiment are understood as follows, for example.
[0079] (1) The flask tray 10 according to the first aspect includes a placement plate 20 having a placement surface 21 on which a flask 2 having a flask body 3 extending in the vertical direction V around an axis and a lid portion 7 fastened to the mouth portion 6 of the flask body 3 is placed, a plurality of leaf spring portions 31c provided in the circumferential direction of the axis so as to extend upward from the placement surface 21 and capable of pressing the flask body 3 inward in the radial direction of the axis, and an annular ring spring extending in the circumferential direction across the plurality of leaf spring portions 31c and capable of clamping the flask body 3 from the outer peripheral side.
[0080] According to such a configuration, by pressing radially inward by the leaf spring portion 31c, the flask 2 can be stably placed. Further, since the ring spring holds the outer peripheral surface 5 of the flask 2 in a clamping manner, it is possible to hold the flask 2 more stably while suppressing the deviation of the posture of the flask 2. Since the leaf spring portion 31c and the ring spring are each configured to elastically deform in the radial direction of the flask 2, it is possible to easily place the flask 2 on the flask tray 10 and remove it from the flask tray 10.
[0081] (2) The flask tray 10 according to the second aspect includes a base plate portion 31a interposed between the bottom surface 4 of the flask body 3 and the placement surface 21, and the leaf spring portion 31c having a lower end connected to the base plate portion 31a so as to be elastically deformable, a holding member 31, a screw 33 extending along the axis and fixing the base plate portion 31a to the placement plate 20, and a rotation preventing member 35 provided on the placement surface 21 and abutting against the holding member 31 from the circumferential direction, which is the flask tray 10 of (1).
[0082] Thereby, the leaf spring portion 31c can be easily arranged, and it is possible to suppress the screw 33 from rotating due to the torque generated when the lid portion 7 is attached to and detached from the flask body 3.
[0083] (3) In the flask tray 10 according to the third aspect, the lid portion 7 is fastened to the mouth portion 6 by being rotated in one direction in the circumferential direction, the screw 33 fixes the base plate portion 31a by being rotated in one side in the circumferential direction, and the rotation preventing member 35 abuts against the holding member 31 from the other side in the circumferential direction, which is the flask tray 10 of (2).
[0084] Thereby, it is possible to suppress the holding member 31 from falling off due to the torque particularly when removing the lid portion 7 from the flask 2.
[0085] (4) The flask tray 10 according to the fourth aspect is provided so as to be laminated on the base plate portion 31a from above on the placement surface 21, and further includes a placement plate 32 on which the bottom surface 4 of the flask body 3 abuts. The screw 33 fixes the placement plate 32 to the placement plate 20 together with the base plate portion 31a. It is the flask tray 10 of (2) or (3).
[0086] Thereby, it is possible to avoid the flask 2 and the holding member 31 from coming into direct contact. Also, the height position of the flask 2 placed on the flask tray 10 can be adjusted.
[0087] (5) The flask tray 10 according to the fifth aspect includes a support column 40 extending upward from the placement plate 20, and a frame 50 that is supported by the support column 40 above the placement plate 20 and surrounds the flask 2 from the horizontal direction so that the flask 2 can be placed on the placement surface 21 from above. The frame 50 has a lid placement portion 60 capable of holding the lid portion 7, and is the flask tray 10 according to any one of (1) to (4).
[0088] Thereby, when the lid portion 7 is removed, the lid portion 7 can be handled in association with the flask body 3.
[0089] (6) The flask unit 1 according to the sixth aspect is such that the lid placement portion 60 has a hole 61 that penetrates the frame 50 in the vertical direction V and into which the lid portion 7 can be inserted, and a plurality of convex portions 62 that protrude from the inner peripheral surface of the hole 61 and are provided in the circumferential direction. It is the flask tray 10 of (5).
[0090] Thereby, it is possible to suppress the culture solution or the like adhering to the lid portion 7 from staying in the flask tray 10.
[0091] (7) The flask unit 1 according to the seventh aspect, the column 40 has a columnar column body 41 extending in the vertical direction V, a lower screw shaft 41a protruding from the lower end of the column body 41, and an upper screw hole 41b recessed from the upper end of the column body 41. The mounting plate 20 has a lower screw hole 25 that is recessed from the mounting surface 21 and into which the lower screw shaft 41a can be fastened. The frame 50 has a screw insertion hole 54 that penetrates the frame 50 in the vertical direction V at a horizontal position corresponding to the column 40. The upper screw 42 that fixes the column 40 and the frame 50 is further provided, which is inserted into the screw insertion hole 54 from above and fastened to the upper screw hole 41b. It is the flask tray 10 of (5) or (6).
[0092] Thus, when assembling the flask unit 1, the column 40 may be inserted into the mounting plate 20 from above, and further, the frame 50 may be fitted onto the column 40 from above. Therefore, the assembly becomes easy. Also, since the screws are not fastened from below, it is possible to avoid the screws from falling off downward.
[0093] (8) The flask tray 10 according to the eighth aspect, the mounting plate 20 has an insertion recess 24 into which the lower end of the column body 41 is inserted and fitted from above, and the frame 50 has an externally fitted recess 53 that is externally fitted onto the upper end of the column body 41 from above. It is the flask tray 10 of any one of (5) to (7).
[0094] Thereby, the positioning accuracy of the mounting plate 20 and the frame 50 with respect to the column 40 can be improved.
[0095] (9) The flask tray 10 according to the ninth aspect, the mounting plate 20 has a plurality of positioning holes penetrating in the vertical direction V, and the plurality of positioning holes include a first hole portion 23a having a circular shape in plan view and a second hole portion 23b having a long hole shape in plan view. It is the flask tray 10 of any one of (1) to (8).
[0096] This makes it possible to easily position the flask tray 10 on various stages 160 while allowing for assembly errors of the system and machining errors of the components.
[0097] (10) The flask tray 10 according to the tenth aspect is the flask tray 10 of any one of (1) to (9), which is fixed to the lower surface of the frame 50 and further includes a tag reader 70 disposed at a distance above the placement surface 21.
[0098] This enables management for each flask tray 10. Also, it can be suppressed that the tag reader 70 itself obstructs the visibility of the culture solution in the flask tray 10.
[0099] (11) The flask tray 10 according to the eleventh aspect includes a placement plate 20 having a placement surface 21 on which a flask 2 having a flask main body 3 extending in the vertical direction about an axis and a lid portion 7 fastened to the mouth portion 6 of the flask main body 3 is placed, a support column 40 extending upward from the placement plate 20, and a frame 50 that is supported by the support column 40 above the placement plate 20 and surrounds the flask 2 in the horizontal direction so that the flask 2 can be placed on the placement surface 21 from above. The frame 50 has a lid placement portion 60 capable of holding the lid portion 7. The lid placement portion 60 has a hole 61 that penetrates the frame 50 in the vertical direction V and has an inner diameter into which the lower portion of the lid portion 7 can be inserted, and a plurality of convex portions 62 protruding from the inner peripheral surface of the hole 61 and provided in the circumferential direction.
[0100] (12) The flask tray 10 according to the 11th aspect includes a mounting plate 20 having a mounting surface 21 on which the flask 2 is placed, a support column 40 extending upward from the mounting plate 20, and a frame 50 that is supported by the support column 40 above the mounting plate 20 and surrounds the flask 2 from the horizontal direction so that the flask 2 can be placed on the mounting surface 21 from above. The support column 40 has a columnar support column body 41 extending in the vertical direction V, a lower screw shaft 41a protruding from the lower end of the support column body 41, and an upper screw hole 41b recessed from the upper end of the support column body 41. The mounting plate 20 has a lower screw hole 25 that is recessed from the mounting surface 21 and into which the lower screw shaft 41a can be fastened, and an insertion recess 24 into which the lower end of the support column body 41 is inserted and fitted from above. The frame 50 has an outer fitting recess 53 that is externally fitted to the upper end of the support column body 41 from above, and a screw insertion hole 54 that penetrates the frame 50 in the vertical direction V. The upper screw 42 that is inserted into the screw insertion hole 54 from above and fastened to the upper screw hole 41b is further provided to fix the support column 40 and the frame 50.
[0101] (13) The flask unit 1 according to the 13th aspect includes any one of the flask trays 10 from (1) to (12) and the flask 2.
[0102] (14) The cell culture system 100 according to the 14th aspect includes the flask unit 1 of (13), a stocker that forms a storage area for storing the flask unit 1, an incubator 130 that forms a culture area R3 for performing a culture operation on the flask unit 1, a clean bench 140 that forms a liquid operation area R4 for performing a dispensing operation on the flask unit 1, and a transfer device that transfers the flask unit 1 across the stocker, the incubator 130, and the clean bench 140.
Explanation of Signs
[0103] 1 Flask unit 2 Flask 3 Flask body 4 Bottom surface 5 Outer peripheral surface 6 Mouth part 7 Lid part 10 Flask tray 20 Mounting plate 21 Mounting surface 22 Back surface 23 Positioning hole 23a First hole part 23b Second hole part 24 Insertion recess 25 Lower screw hole 30 Fixing structure 31 Holding member 31a Base plate part 31b Bent part 31c Leaf spring part 31d Gripping part 32 Mounting disk 33 Screw 34 Elastic ring 35 Anti-rotation member 40 Support column 41 Support column body 41a Lower screw shaft 41b Upper screw hole 42 Upper screw 42a Head part 42b Upper male screw shaft 50 Frame 51 Frame upper surface 52 Frame lower surface 53 Outer fitting recess 54 Screw insertion hole 55 Opening 56 Conveying hole part 60 Lid placement part 61 Hole 62 Protrusion 70 Tag reader 71 Support part 72 Tag reader body 100 Cell culture system 110 First stocker 110a First stocker door 120 Second stocker 120a Second stocker door 130 Incubator 140 Clean Bench 150 Pass Box 150a First Pass Door 150b Second Pass Door 160 Stage 161 Positioning Pin R1 First Storage Area R2 Second Storage Area R3 Cultivation Area R4 Liquid Operation Area D1 First Direction D2 Second Direction V Up and Down Direction O1 First Axis O2 Second Axis O3 Third Axis
Claims
1. A placement plate having a placement surface on which a flask having a flask body extending vertically about an axis and a lid fastened to the mouth of the flask body is placed, a plurality of leaf spring portions provided in the circumferential direction of the axis so as to extend upward from the placement surface and capable of pressing the flask body inward in the radial direction of the axis, a ring spring extending in the circumferential direction across the plurality of leaf spring portions and capable of clamping the flask body from the outer peripheral side, and a flask tray comprising the same.
2. a base plate portion interposed between the bottom surface of the flask body and the placement surface, the leaf spring portion having a lower end elastically deformably connected to the base plate portion, a holding member having the same, a screw extending along the axis and fixing the base plate portion to the placement plate, a detent member provided on the placement surface and abutting against the holding member from the circumferential direction, and the flask tray according to claim 1, comprising the same.
3. the lid is fastened to the mouth by being rotated in one direction in the circumferential direction, the screw fixes the base plate portion by being rotated to one side in the circumferential direction, and the detent member abuts against the holding member from the other side in the circumferential direction, and the flask tray according to claim 2.
4. further comprising a placement tray provided so as to be laminated on the base plate portion from above on the placement surface and against which the bottom surface of the flask body abuts from above, and the screw fixes the placement tray to the placement plate together with the base plate portion, and the flask tray according to claim 2.
5. a support column extending upward from the placement plate, a frame supported by the support column above the placement plate and surrounding the flask in the horizontal direction so that the flask can be placed on the placement surface from above, and the flask tray according to claim 1, comprising the same. the frame has a lid placement portion capable of holding the lid.
6. the lid placement portion, a hole penetrating the frame in the vertical direction and having an inner diameter into which the lower portion of the lid can be inserted, and a plurality of convex portions protruding from the inner peripheral surface of the hole and provided in the circumferential direction, and the flask tray according to claim 5, comprising the same.
7. the support column, a columnar support column body extending in the vertical direction, a lower screw shaft protruding from the lower end of the support column body, and an upper screw hole recessed from the upper end of the support column body, and having the same, The placement plate has a lower screw hole that is recessed from the placement surface and into which the lower screw shaft can be fastened. The frame has a screw insertion hole that penetrates the frame in the vertical direction at a horizontal position corresponding to the support column. The flask tray according to claim 5, further comprising an upper screw that is inserted into the screw insertion hole from above and fastened to the upper screw hole to fix the support column and the frame.
8. The placement plate has an insertion recess into which the lower end of the support column body is inserted and fitted from above. The flask tray according to any one of claims 7, wherein the frame has an externally fitted recess that is externally fitted to the upper end of the support column body from above.
9. The placement plate has a plurality of positioning holes that penetrate in the vertical direction. The plurality of positioning holes include a first hole portion that is circular in plan view and a second hole portion that is elongated in plan view. The flask tray according to claim 1.
10. The flask tray according to claim 5, further comprising a tag reader that is fixed to the lower surface of the frame and is disposed spaced apart upward from the placement surface.
11. A placement plate having a placement surface on which a flask having a flask body extending vertically about an axis and a lid fastened to the mouth of the flask body is placed, a support column extending upward from the placement plate, and a frame that is supported by the support column above the placement plate and surrounds the flask in the horizontal direction so that the flask can be placed on the placement surface from above. The flask tray comprises: the frame has a lid placement portion capable of holding the lid portion, the lid placement portion has a hole that penetrates the frame in the vertical direction and has an inner diameter into which the lower portion of the lid portion can be inserted, and convex portions that project from the inner peripheral surface of the hole and are provided in a plurality in the circumferential direction. The flask tray having the above.
12. A placement plate having a placement surface on which a flask is placed, a support column extending upward from the placement plate, and a frame that is supported by the support column above the placement plate and surrounds the flask in the horizontal direction so that the flask can be placed on the placement surface from above. The flask tray comprises: the support column has a support column body that is columnar and extends in the vertical direction, a lower screw shaft that projects from the lower end of the support column body, and an upper screw hole that is recessed from the upper end of the support column body. The support column has the above. The placement plate has a lower screw hole that is recessed from the placement surface and into which the lower screw shaft can be fastened. an insertion recess into which the lower end of the column body is inserted and fitted from above, and having, the frame, an outer fitting recess that is externally fitted to the upper end of the column body from above, a screw insertion hole that penetrates the frame in the vertical direction, and having, a flask tray further comprising an upper screw that is inserted into the screw insertion hole from above and fastened to the upper screw hole to fix the column and the frame.
13. a flask tray according to any one of claims 1 to 12, the flask, and a flask unit comprising the same.
14. a flask unit according to claim 13, a stocker that forms a storage area for storing the flask unit, an incubator that forms a culture area for performing a culture operation on the flask unit, a clean bench that forms a liquid operation area for performing a dispensing operation on the flask unit, and a transport device that transports the flask unit across the stocker, the incubator, and the clean bench, and a cell culture system comprising the same.
Citation Information
Patent Citations
Cell culture apparatus and its control method
JP4403169B2