Cosmetic

Abstract

To provide a cosmetic that is superior in terms of light spreading, rapid settling, a substantial feel during application, and a moist sensation after application.SOLUTION: A cosmetic comprises: (a) a specific pyrimidylpyrazole compound or a pharmaceutically acceptable salt thereof; (b) at least one selected from the group consisting of specific polyoxyethylene dialkyl esters and polyoxyethylene dialkyl ethers; and (c) at least one selected from the group consisting of specific polyoxyethylene alkyl esters and polyoxyethylene alkyl ethers.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to cosmetics.

Background Art

[0002] Conventionally, for the purpose of maintaining the emulsion stability of topical skin preparations such as cosmetics, quasi-drugs, and pharmaceuticals, α-gel-containing topical skin preparations using an α-gel formed by a higher aliphatic alcohol or higher fatty acid and a hydrophilic surfactant have been used.

[0003] On the other hand, topical skin preparations such as cosmetics, quasi-drugs, and pharmaceuticals are formulated with oil components and humectants for the purpose of preventing skin roughness due to drying of the outside air. The oil components and humectants play the role of sebum lost by washing or the like, and impart to the topical skin preparation the action as an emollient for keeping the skin soft and the moisturizing action as a substitute for NMF (Natural Moisture Rising Factor).

[0004] However, oil components and humectants have the drawback that they tend to cause greasiness and stickiness when formulated in large amounts. In particular, when an α-gel formed by a higher aliphatic alcohol or higher fatty acid and a hydrophilic surfactant is also formulated for the purpose of maintaining emulsion stability, a large amount of the aqueous phase is oriented between the lamellar layers of the α-gel formed in water and is not easily evaporated, so the stickiness during application does not easily disappear.

[0005] On the other hand, a composition for forming an α-gel that is non-greasy during application, has a high skin moisturizing effect after application, and has high stability without crystal precipitation or viscosity increase over time, and a topical skin composition using the same have been proposed (see Patent Document 1).

Prior Art Documents

Patent Documents

[0006]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0007] In view of the above, an aspect of the present invention aims to provide a cosmetic excellent in lightness of elongation, quickness of stopping, richness during application, and moist feeling after application.

Means for Solving the Problems

[0008] To solve the above problems, an aspect of the cosmetic according to the present invention comprises: (a) a pyrimidylpyrazole compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof,

[0009]

Chem.

[0010]

Chem.

[0011] [Chemistry] (However, in the general formula (3), R 9 represents a linear aliphatic residue, linear aliphatic acid residue, or linear aliphatic alcohol residue having 16 to 24 carbon atoms, and n represents an integer of 5 to 30.) It is characterized by containing [Advantages of the Invention]

[0012] According to one aspect of the present invention, it is possible to provide a cosmetic excellent in lightness of elongation, quickness of stopping, richness during application, and moist feeling after application. [Modes for Carrying Out the Invention]

[0013] Hereinafter, embodiments of the present invention will be described in detail. Note that the embodiments are not limited by the following description and can be appropriately changed without departing from the gist of the present invention. In addition, in this specification, "~" indicating a numerical range means including the numerical values described before and after it as the lower limit value and the upper limit value unless otherwise specified.

[0014] (Cosmetic) The cosmetic according to one embodiment contains (a) a pyrimidylpyrazole compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof, (b) at least one selected from the group consisting of polyoxyethylene dialkyl esters and polyoxyethylene dialkyl ethers represented by the following general formula (2), and (c) at least one selected from the group consisting of polyoxyethylene alkyl esters and polyoxyethylene alkyl ethers represented by the following general formula (3), and preferably further contains (d) water, and further contains other components as necessary.

[0015] [Chemistry] (In the general formula (1), R 1 , R 3, R 4 , and R 6 each independently represents an alkyl group having 1 to 3 carbon atoms, and R 2 and R 5 each independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.)

[0016] [Chemical formula] (However, in the general formula (2), R 7 and R 8 each independently represents a linear aliphatic acid residue or a linear aliphatic alcohol residue having 16 to 24 carbon atoms, and n represents an integer of 4 to 15.)

[0017] [Chemical formula] (However, in the general formula (3), R 9 represents a linear aliphatic acid residue or a linear aliphatic alcohol residue having 16 to 24 carbon atoms, and n represents an integer of 8 to 30.)

[0018] Conventional technologies, for example, the skin-external composition of Patent Document 1 has a refreshing usability. While taking advantage of such usability and further improving the usability, when trying to achieve a rich feeling during application and a moist feeling after application, it is necessary to increase the amount of the moisturizing component and the thickening agent. However, the present inventor has found a problem that when the amount of the moisturizing component and the thickening agent is increased, the stretching during application becomes heavy and the usability becomes extremely slow.)

[0019] Therefore, the present inventor has conducted intensive studies to achieve a richness during application and a moist feeling after application without impairing the lightness of elongation and the quickness of stopping. A cosmetic containing (a) a pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof, (b) at least one selected from the group consisting of a polyoxyethylene dialkyl ester and a polyoxyethylene dialkyl ether represented by the general formula (2), and (c) at least one selected from the group consisting of a polyoxyethylene alkyl ester and a polyoxyethylene alkyl ether represented by the general formula (3) has been found to be able to simultaneously achieve the contradictory usability of the lightness of elongation and the quickness of stopping, and the richness during application and the moist feeling after application.

[0020] <(a) A pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof> The pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof (hereinafter sometimes referred to as the “component (a)”) has very low cytotoxicity. The component (a) is mainly formulated in the cosmetic according to one embodiment to improve the richness during application and the moist feeling after application, and does not impair the lightness of elongation and the quickness of stopping of the cosmetic according to one embodiment.

[0021] In the general formula (1), R 1 、R 3 、R 4 、and R 6 each independently represents an alkyl group having 1 to 3 carbon atoms. In one embodiment, the “alkyl group having 1 to 3 carbon atoms” represented by R 1 、R 3 、R 4 、and R 6 is a linear, branched, or cyclic saturated hydrocarbon group having 1 to 3 carbon atoms. Also, in one embodiment, “each independently” means that R 1 、R 3 、R 4 、and R 6means that they may be alkyl groups having 1 to 3 carbon atoms which are different from each other, or may be the same alkyl group having 1 to 3 carbon atoms.

[0022] R 1 、R 3 、R 4 、and R 6 Examples of the alkyl group having 1 to 3 carbon atoms represented by R 1 、R 3 、R 4 、and R 6 include, for example, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, a cyclopropyl group and the like. Among these, as the alkyl group having 1 to 3 carbon atoms represented by R

[0023] In the general formula (1), R 2 and R 5 each independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms. In one embodiment, the "alkyl group having 1 to 3 carbon atoms" represented by R 2 and R 5 is a linear, branched or cyclic saturated hydrocarbon group having 1 to 3 carbon atoms. Further, in one embodiment, "each independently" means that R 2 and R 5 may be different hydrogen atoms or alkyl groups having 1 to 3 carbon atoms, or may be the same hydrogen atom or alkyl group having 1 to 3 carbon atoms.

[0024] R 2 and R 5 Examples of the alkyl group having 1 to 3 carbon atoms represented by R 2 and R 5 include, for example, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, a cyclopropyl group and the like. As R

[0025] Examples of the pharmacologically acceptable salts of the pyrimidylpyrazole compound represented by the general formula (1) include inorganic acid salts such as hydrochloride, hydrobromide, sulfate, and phosphate; and organic acid salts such as acetate, propionate, citrate, lactate, oxalate, maleate, fumarate, succinate, tartrate, and methanesulfonate.

[0026] As the pyrimidylpyrazole compound represented by the general formula (1), those appropriately synthesized by known methods may be used, or commercially available products may be used.

[0027] Typical synthesis examples of the pyrimidylpyrazole compound represented by the general formula (1) will be described below, but are not limited thereto. Examples of the method for synthesizing the pyrimidylpyrazole compound represented by the general formula (1) include the method of synthesizing by the reaction shown in the following Scheme 1. The reaction shown in the following Scheme 1 can be carried out, for example, according to the methods described in JP-A-62-000404, Dharmpal S Dodd et al., Tetrahedron Letters, Volume 45, Issue 22, 2004, p.4265-4267, Gazzetta Chemica Italiana, Vol. 93, Parte I, 1963, p. 100, etc.

[0028]

Chemical formula

[0029] In Scheme 1, the reaction between the hydrazine compound represented by the general formula (2) and the 1,3-dicarbonyl compound represented by the general formula (3a) or the 1-sulfonyl-3-carbonyl compound represented by the general formula (3b) can be carried out, for example, in a suitable solvent such as methanol, under an acid catalyst such as hydrochloric acid or acetic acid, with heating as necessary.

[0030] The pharmacologically acceptable salts of the pyrimidylpyrazole compounds represented by the general formula (1) may be synthesized as appropriate by known methods or commercially available products may be used. Examples of the synthesis of the pharmacologically acceptable salts of the pyrimidylpyrazole compounds represented by the general formula (1) include a method of converting the pyrimidylpyrazole compounds represented by the general formula (1) into acid addition salts appropriately selected from known methods. Examples of the acids used in the method of converting into acid addition salts include inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, and phosphoric acid; and organic acids such as acetic acid, propionic acid, citric acid, lactic acid, oxalic acid, maleic acid, fumaric acid, succinic acid, tartaric acid, and methanesulfonic acid.

[0031] The hydrazine compounds represented by the general formula (2) used as the starting materials in Scheme 1 may be synthesized as appropriate by known methods or commercially available products may be used. Examples of the synthesis of the hydrazine compounds represented by the general formula (2) include a method of synthesizing by the reaction shown in Scheme 2 below. The reaction shown in Scheme 2 below can be carried out, for example, according to the method described in JP-A-8-208620.

[0032]

Chemical formula

[0033] In addition, the hydrazine compound represented by the general formula (2) used as the starting material of Scheme 1 can also be synthesized from the pyrimidine compound represented by the general formula (5) having a leaving group Z by the reaction shown in the following Scheme 3. Examples of the leaving group Z in the pyrimidine compound represented by the general formula (5) include halogen. The reaction shown in the following Scheme 3 can be carried out, for example, according to the methods described in Takeo Naito et al., Chemical and Pharmaceutical Bulletin, 1969, Vol. 17, No. 7, p. 1467-1478, Kaname Takagi et al., Chemical and Pharmaceutical Bulletin, 1963, Vol. 11, No. 11, p. 1382-1388, Kenzo Shirakawa, Yakugaku Zasshi, 1953, Vol. 73, No. 6, p. 635-639, etc.

[0034]

Chemical formula

[0035] Regarding the other compounds used in the reactions of Schemes 1 to 3, those appropriately synthesized by known methods may be used, or commercially available products may be used.

[0036] In the reactions of Schemes 1 to 3, when a functional group is present in the molecule and this functional group may interfere with the reaction or there is a risk thereof, it is preferable to use an appropriate protecting group to efficiently proceed the reaction. The use of the protecting group can be carried out, for example, according to the methods described in Theodora W. Greene, Peter G. M. Wuts, GREENE'S PROTECTIVE GROUPS IN ORGANIC SYNTHESIS, etc.

[0037] In the reactions of Schemes 1 to 3, when isomers such as conformational isomers, geometric isomers, and optical isomers are present, by appropriately selecting the raw materials and reaction conditions and performing separation operations, they can be obtained as pure isomers or geometric isomers. The pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof includes pure isomers or mixtures thereof.

[0038] As the pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof, R 1 、R 3 、R 4 、and R 6 are methyl groups, and R 2 and R 5 are hydrogen atoms, and 2-(3,5-dimethylpyrazol-1-yl)-4,6-dimethylpyrimidine hydrochloride (also referred to as "dimethylpyrazolyl dimethylpyrimidine hydrochloride") is particularly preferred.

[0039] In the cosmetic according to one embodiment, the content of the component (a) is not particularly limited and can be appropriately selected according to the purpose. However, with respect to the total mass of the cosmetic, 0.1% by mass to 1.5% by mass is preferred, 0.1% by mass to 1% by mass is more preferred, and 0.5% by mass to 1% by mass is even more preferred. When the content of the component (a) is 0.1% by mass or more, the richness during application and the moist feeling after application can be suitably improved. In addition, even if the component (a) is blended in excess, a remarkable effect commensurate with the increase in amount may not be obtained, and it may affect formulation design and usability, etc., so it is preferably 1.5% by mass or less.

[0040] <(b) At least one selected from the group consisting of polyoxyethylene dialkyl esters and polyoxyethylene dialkyl ethers represented by the general formula (2)> At least one selected from the group consisting of polyoxyethylene dialkyl esters and polyoxyethylene dialkyl ethers contained in the cosmetic according to one embodiment is a compound represented by the following general formula (2) (hereinafter sometimes referred to as “component (b)”). In addition, the bonding mode of the polyoxyethylene chain and the alkyl group in one molecule may be an ester, an ether, or both may be included.

[0041] [Chemical formula] (However, in the general formula (2), R 7 and R 8 each independently represent a linear aliphatic acid residue or a linear aliphatic alcohol residue having 16 to 24 carbon atoms, and n represents an integer of 4 to 15.)

[0042] In one embodiment, “each independently” means that R 7 and R 8 may be different linear aliphatic acid residues or linear aliphatic alcohol residues having 16 to 24 carbon atoms, or may be the same linear aliphatic acid residues or linear aliphatic alcohol residues having 16 to 24 carbon atoms.

[0043] In the general formula (2), R 7 and R 8 each independently represent a linear aliphatic acid residue or a linear aliphatic alcohol residue having 16 to 24 carbon atoms, but a linear aliphatic acid residue having 16 to 24 carbon atoms is preferred.

[0044] (b) Specific examples of the component include polyoxyethylene (4) distearate (PEG-4 distearate), polyoxyethylene (6) distearate (PEG-6 distearate), polyoxyethylene (8) distearate (PEG-8 distearate), polyoxyethylene (12) distearate (PEG-12 distearate), steareth-4 stearate, steareth-6 stearate, steareth-9 stearate, and the like. These may be used alone or in combination of two or more. The numbers in parentheses indicate the average number of moles of ethylene oxide added, denoted by n in the general formula (2).

[0045] (b) The component may be synthesized appropriately by a known method or a commercially available product may be used. Examples of commercially available products of the component (b) include, for example, EMALEX 200di-S (PEG-4 distearate), EMALEX 300di-S (PEG-6 distearate), EMALEX 400di-S (PEG-8 distearate), EMALEX 600di-S (PEG-12 distearate), EMALEX SWS-4 (steareth-4 stearate), EMALEX SWS-6 (steareth-6 stearate), EMALEX SWS-9 (steareth-9 stearate) (all manufactured by Nippon Emulsion Co., Ltd.), and the like.

[0046] In the cosmetic according to one embodiment, the content of the component (b) is not particularly limited and can be appropriately selected according to the purpose. However, with respect to the total mass of the cosmetic, 0.01% by mass to 5% by mass is preferable, 0.1% by mass to 5% by mass is more preferable, and 0.1% by mass to 0.5% by mass is even more preferable. When the content of the component (b) with respect to the total mass of the cosmetic is 0.01% by mass to 5% by mass, an appropriate viscosity can be obtained, and the lightness of elongation and the quickness of stopping are good.

[0047] Also, the content of the component (b) relative to the total content of the component (b) and the component (c) described below is not particularly limited, but is preferably 15% by mass to 45% by mass, and more preferably 20% by mass to 70% by mass. When the content of the component (b) relative to the total content of the component (b) and the component (c) is 15% by mass to 45% by mass, it is easy to form an α-gel phase, and the lightness of elongation and the quickness of stopping can be improved.

[0048] "α-gel" means an aggregate formed by a higher aliphatic alcohol and a hydrophilic surfactant in water, and means a gel having an α-structure (by Shoji Fukushima, "Physical Chemistry of Cetyl Alcohol", published by Fragrance Journal). In the cosmetic according to one embodiment, mainly, the component (b) and the component (c) form an aggregate in water.

[0049] <(c) at least one selected from the group consisting of polyoxyethylene alkyl esters and polyoxyethylene alkyl ethers represented by the general formula (3)> At least one selected from the group consisting of polyoxyethylene alkyl esters and polyoxyethylene alkyl ethers contained in the cosmetic according to one embodiment is a compound represented by the following general formula (3) (hereinafter, may be referred to as "component (c)"). In addition, the bonding mode of the polyoxyethylene chain and the alkyl group in one molecule may be an ester, an ether, or both.

[0050]

Chem.

[0051] In the general formula (3), R 9 represents a linear aliphatic residue, a linear aliphatic acid residue, or a linear aliphatic alcohol residue having 16 to 24 carbon atoms, and a linear aliphatic residue having 16 to 24 carbon atoms is preferred.

[0052] (c) Specific examples of the component include polyoxyethylene (5) behenyl ether (Behes-5), polyoxyethylene (10) behenyl ether (Behes-10), polyoxyethylene (20) behenyl ether (Behes-20), polyoxyethylene (30 mol) behenyl ether (Behes-30), polyoxyethylene (10) stearyl ether (Steares-10), polyoxyethylene (7) cetyl ether (Cetes-7), and the like. These may be used alone or in combination of two or more. The numbers in parentheses indicate the average number of moles of ethylene oxide added, represented by n in the general formula (3).

[0053] (c) The component may be appropriately synthesized by a known method or a commercially available product may be used. Examples of commercially available products of the (c) component include NIKKOL BB-5 (Behes-5), NIKKOL BB-10 (Behes-10), NIKKOL BB-20 (Behes-20), NIKKOL BB-30 (Behes-30), NIKKOL HCO-20 (PEG-20 hydrogenated castor oil), NIKKOL HCO-60 (PEG-60 hydrogenated castor oil), NIKKOL TS-10V (polysorbate 60) (all of the above are manufactured by Nikko Chemicals Co., Ltd.), EMALEX 610 (Steares-10), EMALEX 107 (Cetes-7), EMALEX GM-5 (PEG-5 glyceryl stearate), EMALEX GM-10 (PEG-10 glyceryl stearate) (all of the above are manufactured by Nippon Emulsion Co., Ltd.), and the like.

[0054] In the cosmetic according to one embodiment, the content of the (c) component is not particularly limited and can be appropriately selected according to the purpose. However, with respect to the total mass of the cosmetic, 0.01% by mass to 5% by mass is preferable, 0.1% by mass to 5% by mass is more preferable, and 0.1% by mass to 0.5% by mass is even more preferable. When the content of the (c) component is 0.01% by mass to 5% by mass, an appropriate viscosity can be obtained, and the lightness of elongation and the quickness of stopping are good.

[0055] <<Mass ratio [(component (b)) / (component (c))]>> In the cosmetic according to one embodiment, the mass ratio [(component (b)) / (component (c))] between the content (mass %) of component (b) and the content (mass %) of component (c) is not particularly limited and can be appropriately selected according to the purpose, but 1 / 9 to 7 / 3 is preferable. When the mass ratio [(component (b)) / (component (c))] is within the range of 1 / 9 to 7 / 3, crystals are less likely to precipitate, which is suitable for the formulation.

[0056] <(d) Water> From the viewpoint of the stability of the formulation, it is preferable that the cosmetic according to one embodiment further contains water in addition to component (a), component (b), and component (c).

[0057] The content of water is not particularly limited and can be appropriately selected according to the purpose. However, based on the total mass of the cosmetic, 20 mass % to 80 mass % is preferable, 20 mass % to 70 mass % is more preferable, and 30 mass % to 60 mass % is even more preferable.

[0058] <Other components> The cosmetic according to one embodiment may contain other components other than component (a), component (b), component (c), and component (d). The other components are not particularly limited and can be appropriately selected from known components used in cosmetics. For example, oily components, higher alcohols, glycols, glycerols, sugar alcohols, saccharides, powder components, pigments, dyes, polymers, ultraviolet absorbers, surfactants other than component (b) and component (c), pH adjusters, antioxidants, antioxidant aids, sequestering agents, various drugs other than component (a), solvents, and other various additives. These can be used alone or in combination of two or more. These additives may also be referred to as stabilizers.

[0059] The content of the other components in the cosmetic according to one embodiment is not particularly limited as long as the effects of the cosmetic according to one embodiment are not impaired, and can be appropriately selected according to the purpose.

[0060] <<Oily component>> The oily components are not particularly limited, and examples thereof include liquid oils and fats, solid oils and fats, waxes, hydrocarbon oils, higher fatty acids, synthetic ester oils, silicone oils, and the like. These may be used alone or in combination of two or more.

[0061] Examples of the liquid oils and fats include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, peach kernel oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, sinagiri oil, Japanese cedar oil, jojoba oil, germ oil, shea butter, triglycerin, and the like.

[0062] Examples of the solid oils and fats include cocoa butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, beef tallow, mutton fat, hydrogenated beef tallow, palm kernel oil, lard, beef bone fat, mokuro kernel oil, hydrogenated oil, beef foot fat, mokuro, hydrogenated castor oil, and the like.

[0063] Examples of the waxes include beeswax, candelilla wax, cotton wax, carnauba wax, barberry wax, ibota wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, isopropyl lanolin fatty acid, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, polyoxyethylene lanolin alcohol ether, polyoxyethylene lanolin alcohol acetate, polyoxyethylene cholesterol ether, polyethylene glycol lanolin fatty acid, polyoxyethylene hydrogenated lanolin alcohol ether, cetyl palmitate, and the like.

[0064] Examples of the hydrocarbon oils include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, hydrogenated polyisobutene, and the like.

[0065] Examples of the higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, abietic acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and the like.

[0066] Examples of the synthetic ester oils include cetyl octanoate, myristyl myristate, glyceryl tri(2-ethylhexanoate), pentaerythritol tetra(2-ethylhexanoate), dioctyl succinate, tripropylene glycol dineopentanoate, diisopropyl sebacate, diethylhexyl succinate, and the like.

[0067] Examples of the silicone oils include chain polysiloxanes such as dimethylpolysiloxane (dimethyl silicone), methylphenylpolysiloxane (phenyltrimethyl silicone), diphenylpolysiloxane; cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane; silicone resins forming a three-dimensional network structure; silicone rubbers; various modified polysiloxanes such as amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane; acrylic silicones, and the like.

[0068] The cosmetic according to one embodiment may dissolve and emulsify a higher alcohol in these oily components.

[0069] In the cosmetic according to one embodiment, the content of the oily component is not particularly limited as long as the effects of the cosmetic are not impaired, and can be appropriately selected according to the purpose, but 0.05% by mass to 50% by mass is preferable.

[0070] <<Higher Alcohol>> Examples of the higher alcohol include alcohols having 6 or more carbon atoms, and higher aliphatic alcohols having 16 or more carbon atoms are preferred. Specific examples of the higher alcohol include linear or branched higher alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, monostearyl glycerin ether (batyl alcohol), 2-decyltetradecynol, 2-octyldodecanol, lanolin alcohol, cholesterol, phytosterol, hexyl dodecanol, isostearyl alcohol, octyldodecanol, and the like.

[0071] <<Glycols>> Examples of the glycols include propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, 1,2-hexanediol, and the like.

[0072] <<Glycerins>> Examples of the glycerins include glycerin, diglycerin, polyglycerin, and the like.

[0073] <<Sugar Alcohols>> Examples of the sugar alcohols include sorbitol, mannitol, maltitol, xylitol, erythritol, and the like.

[0074] <<Sugars>> Examples of the sugars include fructose, glucose, galactose, maltose, lactose, trehalose, and the like.

[0075] <<Powder Components>> The powder component may be an inorganic powder or an organic powder.

[0076] Examples of the inorganic powder include talc, kaolin, mica, sericite, muscovite, phlogopite, synthetic mica, biotite, vermiculite, bentonite, hectorite, laponite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate salts, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate (calcined gypsum), calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, metal soap, boron nitride, and the like. Examples of the metal soap include zinc myristate, calcium palmitate, aluminum stearate, and the like.

[0077] Examples of the organic powder include polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, and the like.

[0078] [[Pigment]] Examples of the pigment include inorganic pigments, organic pigments, pearl pigments, metal powder pigments, and the like.

[0079] Examples of the inorganic pigment include inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red iron oxide) and iron titanate; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and loess; black pigments such as black iron oxide, lower-order titanium oxide, and carbon black; inorganic purple pigments such as manganese violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and navy blue, and the like.

[0080] Examples of organic pigments include organic pigments such as Pigment Red 201, Pigment Red 202, Pigment Red 204, Pigment Red 205, Pigment Red 220, Pigment Red 226, Pigment Red 228, Pigment Red 405, Pigment Orange 203, Pigment Orange 204, Pigment Yellow 205, Pigment Yellow 401, and Pigment Blue 404; Pigment Red 3, Pigment Red 104, Pigment Red 106, Pigment Red 227, Pigment Red 230, Pigment Red 401, Pigment Red 505, Pigment Orange 205, Pigment Yellow 4, Pigment Yellow 5, Pigment Yellow 202, Pigment Yellow 203, Pigment Green 3, Pigment Blue 1, and their zirconium lakes, barium lakes, or aluminum lakes.

[0081] Examples of pearl pigments include titanium oxide-coated mica, colored titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, bismuth oxychloride, and fish scale foil.

[0082] Examples of metal powder pigments include aluminum powder, copper powder, and the like.

[0083] <<Dye>> Examples of dyes include natural dyes such as chlorophyll and β-carotene.

[0084] <<Polymers>> Examples of polymers include natural polymers such as plant-based polymers, animal-based polymers, and microbial-based polymers; semi-synthetic polymers such as starch-based polymers, cellulose-based polymers, and alginic acid-based polymers; and synthetic polymers such as vinyl-based polymers, acrylic-based polymers, inorganic water-soluble polymers, and polyoxyethylene-based polymers. These polymers may act as thickeners.

[0085] Examples of plant-based polymers include gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, gellan gum, locust bean gum, tamarind gum, carrageenan, pectin, agar, quince seed (medlar), algocolloid (cassou extract), glycyrrhizic acid, and the like.

[0086] Examples of animal-derived polymers include collagen, casein, albumin, gelatin, and the like.

[0087] Examples of microbial-derived polymers include xanthan gum, dextran, succinoglycan, pullulan, and the like.

[0088] Examples of starch-derived polymers include vegetable starches such as corn, wheat, potato, and rice; carboxymethyl starch; methylhydroxypropyl starch, and the like.

[0089] Examples of cellulose-derived polymers include methyl cellulose, nitrocellulose, ethyl cellulose, methylhydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, hydroxypropyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, powdered cellulose, and hydrophobic modified compounds of these polymers (e.g., polymers partially modified with stearoxy) and cationic modified compounds of these polymers.

[0090] Examples of alginic acid-derived polymers include sodium alginate, propylene glycol alginate, and the like.

[0091] Examples of vinyl-derived polymers include polyvinyl alcohol, polyvinyl acetate, polyvinyl methyl ether, polyvinyl pyrrolidone, copolymers of vinyl pyrrolidone and vinyl acetate, carboxyvinyl polymer, polyvinyl acetate, and the like.

[0092] Examples of acrylic-derived polymers include sodium polyacrylate, polyethyl acrylate, alkanolamine polyacrylate, copolymers of alkyl methacrylate and dimethylaminoethyl methacrylate, poly2-acrylamido-2-methylpropanesulfonic acid, polymethacryloyloxytrimethylammonium, and the like.

[0093] Examples of inorganic water-soluble polymers include polyethyleneimine, cationic polymers, bentonite, aluminum magnesium silicate, laponite, hectorite, and silicic anhydride.

[0094] Examples of polyoxyethylene polymers include polyoxyethylene polyoxypropylene copolymers such as polyethylene glycol 300 (PEG-6), polyethylene glycol 400 (PEG-8), polyethylene glycol 600 (PEG-12), polyethylene glycol 1,000 (PEG-20), polyethylene glycol 1,540 (PEG-32), polyethylene glycol 2,000 (PEG-40), polyethylene glycol 4,000 (PEG-75), polyethylene glycol 6,000 (PEG-150), polyethylene glycol 11,000 (PEG-240), and polyethylene glycol 20,000 (PEG-400). Also, as polyoxyethylene polymers, for example, highly polymerized polyethylene glycols such as PEG-2M, PEG-5M, PEG-7M, PEG-9M, PEG-14M, PEG-20M, PEG-23M, PEG-45M, PEG-65M, PEG-90M, PEG-115M, PEG-160M, and PEG-180M can also be used.

[0095] Also, for example, poly(dimethyldiallylammonium halide)-type cationic polymers such as Merquat 100 (manufactured by Merck, USA); copolymer-type cationic polymers of dimethyldiallylammonium halide and acrylamide such as Merquat 550 (manufactured by Merck, USA); polyethyleneimine; cationic polymers; and AlMg silicate (Veegum) can also be used.

[0096] <<Ultraviolet Absorbent>> Examples of the ultraviolet absorber include benzoic acid-based ultraviolet absorbers, anthranilic acid-based ultraviolet absorbers, salicylic acid-based ultraviolet absorbers, caffeic acid-based ultraviolet absorbers, benzophenone-based ultraviolet absorbers, triazine-based ultraviolet absorbers, 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor, 2-phenyl-5-methylbenzoxazole, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole, 2-(2'-hydroxy-5'-methylphenylbenzotriazole, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one, and the like. These may be used alone or in combination of two or more.

[0097] Examples of the benzoic acid-based ultraviolet absorber include para-aminobenzoic acid (hereinafter sometimes abbreviated as "PABA"), PABA monoglycerin ester, N,N-dipropoxy PABA ethyl ester, N,N-diethoxy PABA ethyl ester, N,N-dimethyl PABA ethyl ester, N,N-dimethyl PABA butyl ester, N,N-dimethyl PABA ethyl ester, and the like.

[0098] Examples of the anthranilic acid-based ultraviolet absorber include homomenthyl-N-acetylanthranilate.

[0099] Examples of the salicylic acid-based ultraviolet absorber include amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanolphenyl salicylate, and the like.

[0100] Examples of cinnamic acid-based UV absorbers include octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isoamyl-p-methoxy cinnamate, octyl-p-methoxy cinnamate (2-ethylhexyl-p-methoxy cinnamate), 2-ethoxyethyl-p-methoxy cinnamate, cyclohexyl-p-methoxy cinnamate, ethyl-α-cyano-β-phenyl cinnamate, 2-ethylhexyl-α-cyano-β-phenyl cinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxy cinnamate, and the like.

[0101] Examples of benzophenone-based UV absorbers include 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, and the like.

[0102] Examples of triazine-based UV absorbers include 2-4[(2-hydroxy-3-dodecyloxypropyl)oxy]-2-hydroxyphenyl)-4,6-bis(2,4-dimethylphenyl)-1,3,5-triazine, 2-4[(2-hydroxy-3-tridecyloxypropyl)oxy]-2-hydroxyphenyl)-4,6-bis(2,4-dimethylphenyl)-1,3,5-triazine, and the like.

[0103] <<Surfactants other than component (b) and component (c)>> Examples of surfactants other than component (b) and component (c) include, for example, anionic surfactants, cationic surfactants, nonionic surfactants other than component (b) and component (c), amphoteric surfactants, and the like.

[0104] Examples of anionic surfactants include, for example, fatty acid soaps such as soap bases, sodium laurate, and sodium palmitate; higher alkyl sulfate ester salts such as sodium lauryl sulfate and potassium lauryl sulfate; alkyl ether sulfate ester salts such as triethanolamine polyoxyethylene (hereinafter sometimes abbreviated as "POE") lauryl sulfate and sodium POE lauryl sulfate; N-acyl sarcosinic acids such as sodium lauroyl sarcosinate; higher fatty acid amide sulfonic acids such as sodium N-myristoyl-N-methyl taurate and sodium coconut oil fatty acid methyl tauride; phosphate ester salts such as POE stearyl ether phosphate; sulfosuccinates such as sodium monolauroyl monoethanolamide POE sulfosuccinate and sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonate salts such as sodium linear dodecylbenzene sulfonate and triethanolamine linear dodecylbenzene sulfonate; N-acyl glutamate salts such as disodium N-stearoyl glutamate and sodium N-stearoyl glutamate; higher fatty acid ester sulfate ester salts such as sodium hydrogenated coconut oil fatty acid glycerol sulfate; sulfated oils such as rape oil; POE alkyl ether carboxylic acids; POE alkyl allyl ether carboxylate salts; higher fatty acid ester sulfonate salts; secondary alcohol sulfate ester salts; higher fatty acid alkanolamide sulfate ester salts; sodium lauroyl monoethanolamide succinate; sodium caseinate; N-acyl methyl taurine salts; alkyl quaternary ammonium salts; dialkyl quaternary ammonium salts, and the like.

[0105] Examples of cationic surfactants include alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride; dialkyldimethylammonium salts such as distearyldimethylammonium chloride; alkylpyridinium salts such as cetylpyridinium chloride; alkyl quaternary ammonium salts; alkylbenzyldimethylammonium salts; alkylisoquinolinium salts; dialkylmorphonium salts; POE alkylamines; alkylamine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride, and the like.

[0106] (b) The nonionic surfactant other than the component and the (c) component may be a lipophilic nonionic surfactant or a hydrophilic nonionic surfactant.

[0107] Examples of lipophilic nonionic surfactants include sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexanoate, and diglycerol sorbitan tetra-2-ethylhexanoate; glycerin polyglycerin fatty acids such as monoricinoleic acid glycerin, monoelaidic acid glycerin, sesquiolenic acid glycerin, monostearic acid glycerin, α,α'-oleic acid pyroglutamic acid glycerin, and monostearic acid glycerin malic acid; propylene glycol fatty acid esters such as propylene glycol monostearate; hydrogenated castor oil derivatives; glycerin alkyl ethers, and the like.

[0108] Examples of hydrophilic nonionic surfactants include POE sorbitan fatty acid esters such as POE sorbitan monooleate, POE sorbitan monostearate, POE sorbitan monooleate, and POE sorbitan tetraoleate; POE sorbitol fatty acid esters such as POE sorbitol monolaurate, POE sorbitol monooleate, POE sorbitol pentaoleate, and POE sorbitol monostearate; POE glycerin fatty acid esters such as POE glycerin monostearate, POE glycerin monoisostearate, and POE glycerin triisostearate; POE fatty acid esters such as POE distearate, POE monodioleate, and ethylene glycol distearate; POE alkyl ethers such as POE lauryl ether, POE oleyl ether, POE stearyl ether, POE behenyl ether, POE 2-octyldodecyl ether, and POE cholestanol ether; Pluronic types such as Pluronic; POE·POP alkyl ethers such as POE·polyoxypropylene (hereinafter sometimes abbreviated as "POP") cetyl ether, POE·POP 2-decyltetradecyl ether, POE·POP monobutyl ether, POE·POP hydrogenated lanolin, and POE·POP glycerin ether; tetra-POE·tetra-POP ethylenediamine condensates such as Tetronic; POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil triisostearate, POE hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, and POE hydrogenated castor oil maleic acid; POE honey·lanoilin derivatives such as POE sorbitol beeswax; alkanolamides such as coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, and fatty acid isopropanolamide; POE propylene glycol fatty acid ester; POE alkylamine; POE fatty acid amide; sucrose fatty acid ester; alkyl ethoxydimethylamine oxide; and trioleyl phosphate, etc.

[0109] Examples of the amphoteric surfactant include imidazoline-based amphoteric surfactants such as 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy 2 sodium salt; betaine-based surfactants such as 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkyl betaine, amide betaine, sulfobetaine, etc.

[0110] <<pH adjuster>> Examples of the pH adjuster include potassium hydroxide, sodium hydroxide, triethanolamine, sodium carbonate, lactic acid, sodium lactate, citric acid, sodium citrate, glycolic acid, succinic acid, sodium succinate, tartaric acid, malic acid, sodium hydrogen carbonate, ammonium hydrogen carbonate, etc.

[0111] <<Antioxidant>> Examples of the antioxidant include tocopherols such as tocopherol acetate, dibutylhydroxytoluene (BHT), butylhydroxyanisole, gallic acid esters, etc.

[0112] <<Antioxidant aid>> Examples of the antioxidant aid include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, cephalin, hexametaphosphate, phytic acid, ethylenediaminetetraacetic acid, sodium pyrosulfite, etc.

[0113] <<Metal ion sequestering agent>> Examples of the metal ion sequestering agent include 1-hydroxyethane-1,1-diphosphonic acid, tetrasodium 1-hydroxyethane-1,1-diphosphonate, disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyltriacetate, and the like.

[0114] Drugs other than component (a) Examples of the drugs other than component (a) include vitamins, preservatives, anti-inflammatory agents, skin lightening agents, chelating agents, various extracts, activators, blood circulation promoters, anti-seborrheic agents, anti-inflammatory agents, aromatic alcohols, humectants, cooling agents, amino acids, bactericides, phospholipids, lecithin, lysophosphatidylcholine, ceramides, and the like.

[0115] - Vitamins - Examples of the vitamins include vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E, or derivatives thereof, pantothenic acid or derivatives thereof, biotin, and the like.

[0116] - Preservatives - Examples of the preservatives include benzoic acid, salicylic acid, paraoxybenzoic acid esters (such as methylparaben, ethylparaben, butylparaben, etc.), sorbic acid, parachlorometacresol, hexachlorophene, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, photosensitizer, phenoxyethanol, and the like.

[0117] - Anti-inflammatory agents - Examples of the anti-inflammatory agents include glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, and the like.

[0118] - Skin lightening agents - Examples of skin brighteners include, for example, Saxifraga stolonifera extract, arbutin, 4-methoxysalicylic acid, tranexamic acid, ethyl vitamin C, magnesium ascorbyl phosphate, niacinamide, and the like.

[0119] -Chelating agent- Examples of chelating agents include, for example, citramalic acid, agaric acid, glyceric acid, shikimic acid, hinokitiol, gallic acid, tannic acid, caffeic acid, trisodium ethylenediamine-N,N,N',N'-tetraacetate dihydrate (EDTA-2Na), ethylenediamine tetraacetic acid, diethylenetriaminepentaacetic acid, phytic acid, polyphosphoric acid, metaphosphoric acid, analogs thereof, alkali metal salts thereof, carboxylic acid esters thereof, and the like.

[0120] -Extract- Examples of various extracts include, for example, extracts of Paeonia lactiflora, Coptis japonica, Trichosanthes kirilowii, Paeonia albiflora, Bupleurum falcatum, Betula platyphylla, Salvia officinalis, Eriobotrya japonica, Daucus carota, Aloe vera, Abutilon theophrasti, Iris ensata, Vitis vinifera, Dioscorea opposita, Benincasa hispida, Lilium lancifolium, Crocus sativus, Scutellaria baicalensis, Zingiber officinale, Viola yedoensis, Ononis spinosa, Allium sativum, Capsicum annuum, Cnidium officinale, Atractylodes lancea, seaweed, and the like.

[0121] -Activator- Examples of activators include, for example, royal jelly, photosensitizer, cholesterol derivatives, and the like.

[0122] -Blood circulation promoter- Examples of blood circulation promoters include, for example, nonivamide, benzyl nicotinate, β-butoxyethyl nicotinate, capsaicin, gingerol, cantharidin, ichthyol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, and the like.

[0123] -Sebum regulator- Examples of sebum regulators include, for example, sulfur, thiol, and the like.

[0124] - Anti - inflammatory agent - Examples of the anti - inflammatory agent include tranexamic acid, thiotaurine, hypotaurine, etc.

[0125] - Aromatic alcohol - Examples of the aromatic alcohol include benzyl alcohol, benzyloxyethanol, etc.

[0126] - Humectant - Examples of the humectant include polyethylene glycol, sodium chondroitin sulfate, sodium hyaluronate, sodium lactate, glucosamine, cyclodextrin, polyethylene glycol / polypropylene glycol (PPG) - 17 / 4 dimethyl ether, etc. Also, the glycols, the glycerols, the sugar alcohols, and the saccharides can also be used as humectants.

[0127] - Cooling agent - Examples of the cooling agent include L - menthol, camphor, etc.

[0128] << Solvent >> As the solvent, an aqueous solvent is preferred, and examples include water, lower alcohols, etc. Examples of the lower alcohol include alcohols having 5 or less carbon atoms. Specific examples of the lower alcohol include methanol, ethanol, propyl alcohol, isopropyl alcohol, 2 - amino - 2 - methyl - 1 - propanol, 2 - amino - 2 - methyl - 1,3 - propanediol, etc.

[0129] < Dosage form > The dosage form of the cosmetic according to one embodiment is not particularly limited and can be appropriately selected according to the purpose, but a liquid cosmetic is preferred, a liquid emulsified cosmetic is more preferred, and an oil - in - water emulsion is even more preferred.

[0130] The product form of the cosmetic according to one embodiment is not particularly limited and can be appropriately selected according to the purpose. For example, facial or body skin care cosmetics such as lotion, emulsion, essence, cream, etc., or hair care cosmetics; sunscreen cosmetics; self-tanning cosmetics; skin cleansing cosmetics such as makeup remover; ointments and the like. Further, the product form of the cosmetic according to one embodiment may be in a form impregnated in a substrate such as a pack. Among these, as the product form of the cosmetic according to one embodiment, skin care cosmetics are preferred because they are excellent in lightness of elongation, quickness of stopping, richness during application, and moist feeling after application.

[0131] <Manufacturing method> The manufacturing method of the cosmetic according to one embodiment is not particularly limited and can be manufactured according to the methods commonly used for cosmetics, preferably liquid cosmetics. As a specific example of the manufacturing method of the cosmetic according to one embodiment, first, a water-soluble component appropriately selected from the (a) component, (b) component, (c) component, and (d) component, and further, if necessary, other components is dissolved in water to prepare an aqueous phase. Next, a water-insoluble component appropriately selected from other components is mixed to prepare an oil phase. Finally, a method of manufacturing the cosmetic according to one embodiment by emulsifying the oil phase and the aqueous phase is mentioned.

[0132] The emulsification method is not particularly limited, and known methods can be used. For example, mechanical emulsification methods using high-pressure emulsifiers such as high-pressure homogenizers, high-shear dispersers, colloid mills, etc.; phase inversion emulsification method; aggregation method; liquid crystal emulsification method; D-phase emulsification method; membrane emulsification method, etc. These methods can be used alone or in combination of multiple. Among these, the membrane emulsification method is preferred.

[0133] Membrane emulsification is an emulsification method in which a dispersed-phase liquid is atomized into minute droplets by passing through pores of a porous membrane and dispersed in a continuous phase. Here, the dispersed phase (inner phase) means the liquid phase dispersed as minute droplets. Also, the continuous phase (outer phase) means the liquid phase surrounding the dispersed-phase droplets. Since the droplet diameter of the emulsion prepared by this membrane emulsification is determined by the pore diameter of the membrane through which the dispersed phase passes, the droplet diameter of the emulsion can be arbitrarily controlled by the pore diameter of the porous membrane, and if the pore diameter is uniform, it is also possible to prepare a monodisperse emulsion.

Examples

[0134] Examples and comparative examples are given below to more specifically explain the embodiments, but the embodiments are not limited by these examples and comparative examples. In the examples and comparative examples, the content of each component shown in Table 1 and Table 2 below indicates "mass %" with respect to the total mass of the cosmetic, unless otherwise specified, and all values are in terms of pure components.

[0135] (Examples 1 to 3) Each component was mixed with the composition and content (mass %) shown in Table 1 below to prepare the cosmetics of Examples 1 to 3, respectively. Specifically, first, the water-soluble components among the (a) component, (b) component, (c) component, and other components were dissolved in water to prepare an aqueous phase. Next, the water-insoluble components among the other components were mixed to prepare an oil phase. Finally, the oil phase was added to the aqueous phase and stirred to obtain the oil-in-water type lotion of Examples 1 to 3.

[0136] (Comparative Example 1) An oil-in-water type lotion of Comparative Example 1 was obtained in the same manner as in Example 1, except that the (a) component was not added, according to the composition and content (mass %) shown in Table 1 below.

[0137] <Evaluation> For each of the cosmetics of Examples 1 to 3 and Comparative Example 1, "lightness of elongation", "quickness of stopping", "rich feeling during application", and "moist feeling after application" were evaluated by the following methods. The results are shown in Table 1 below.

[0138] <<Lightness of stretch>> Five professional panels evaluated the lightness of stretch when applying the cosmetics of Examples 1 to 3 and Comparative Example 1 to the skin, respectively, based on the following evaluation criteria. The average score of the five panelists was calculated and judged based on the following judgment criteria. - Evaluation criteria for lightness of stretch - 3 points: Excellent lightness of stretch 2 points: Normal lightness of stretch 1 point: Poor lightness of stretch - Judgment criteria for lightness of stretch - ◎: Average score is 2.7 or more and 3 or less 〇: Average score is 2 or more and less than 2.7 △: Average score is less than 2

[0139] <<Quickness of stopping>> Five professional panels evaluated the quickness of stopping when applying the cosmetics of Examples 1 to 3 and Comparative Example 1 to the skin, respectively, based on the following evaluation criteria. The average score of the five panelists was calculated and judged based on the following judgment criteria. - Evaluation criteria for quickness of stopping - 3 points: Excellent quickness of stopping 2 points: Normal quickness of stopping 1 point: Poor quickness of stopping - Judgment criteria for quickness of stopping - ◎: Average score is 2.7 or more and 3 or less 〇: Average score is 2 or more and less than 2.7 △: Average score is less than 2

[0140] <<Rich feeling during application>> Five professional panels evaluated the rich feeling during the application of the cosmetics of Examples 1 to 3 and Comparative Example 1 to the skin, respectively, based on the following evaluation criteria. The average score of the five panelists was calculated and judged based on the following judgment criteria. - Evaluation criteria for rich feeling during application - 3 points: Excellent rich feeling during application 2 points: Normal rich feeling during application 1 point: Poor rich feeling during application - Judgment criteria for rich feeling during application - ◎: The average score is 2.7 or more and 3 or less 〇: The average score is 2.4 or more and less than 2.7 △: The average score is 2 or more and less than 2.4 ×: The average score is less than 2

[0141] <<Moist feeling after application>> Five professional panelists evaluated the moist feeling on the skin of the cosmetics of Examples 1 to 3 and Comparative Example 1 after application respectively based on the following evaluation criteria. The average score of the five scores was calculated and judged based on the following judgment criteria. - Evaluation criteria for moist feeling after application - 3 points: The moist feeling after application is excellent 2 points: The moist feeling after application is ordinary 1 point: The moist feeling after application is poor - Judgment criteria for moist feeling after application - ◎: The average score is 2.7 or more and 3 or less 〇: The average score is 2.4 or more and less than 2.7 △: The average score is 2 or more and less than 2.4 ×: The average score is less than 2

[0142]

Table 1

[0143] In addition, 2-(3,5-dimethylpyrazol-1-yl)-4,6-dimethylpyrimidine hydrochloride (dimethylpyrazolyl dimethylpyrimidine hydrochloride) used in the examples is a compound represented by the following structural formula (1) produced by the method described in Patent No. 4586108.

[0144]

Chem.

[0145] Examples of the aspects of the present invention include, for example, the following. <1> (a) A pyrimidylpyrazole compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof, and

[0146] [Chemical formula] (In the general formula (1), R 1 , R 3 , R 4 , and R 6 each independently represent an alkyl group having 1 to 3 carbon atoms, and R 2 and R 5 each independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.) (b) At least one selected from the group consisting of a polyoxyethylene dialkyl ester and a polyoxyethylene dialkyl ether represented by the following general formula (2), and

[0147] [Chemical formula] (However, in the general formula (2), R 7 and R 8 each independently represent a linear aliphatic acid residue or a linear aliphatic alcohol residue having 16 to 24 carbon atoms, and n represents an integer of 4 to 15.) (c) At least one selected from the group consisting of a polyoxyethylene alkyl ester and a polyoxyethylene alkyl ether represented by the following general formula (3), and

[0148] [Chemical formula] (However, in the general formula (3), R 9 represents a linear aliphatic residue, a linear aliphatic acid residue, or a linear aliphatic alcohol residue having 16 to 24 carbon atoms, and n represents an integer of 5 to 30.) A cosmetic characterized by containing the same. <2> In the pyrimidylpyrazole compound represented by the general formula (1) in the above (a) or a pharmacologically acceptable salt thereof, R 2 and R 5The cosmetic according to <1>, wherein <1> is a hydrogen atom. <3> R in the pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof in the above (a) 1 R 3 R 4 and R 6 are methyl groups, and the cosmetic according to <1> or <2>. <4> The content of the pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof in the above (a) is 0.1% by mass to 1% by mass, and the cosmetic according to any one of <1> to <3>. <5> The content of at least any one selected from the group consisting of the polyoxyethylene dialkyl ester and the polyoxyethylene dialkyl ether represented by the general formula (2) in the above (b) is 15% by mass to 45% by mass with respect to the total content of the component (b) and the component (c), and the cosmetic according to any one of <1> to <4>. <6> Further containing (d) water, and the content of the (d) water is 20% by mass to 80% by mass, and the cosmetic according to any one of <1> to <5>.

[0149] As described above, the present invention has been described based on specific embodiments and examples, but these embodiments and examples are merely presented as examples, and the present invention is not limited by the above embodiments and examples. The above embodiments can be implemented in various other forms, and various combinations, omissions, replacements, additions, changes, etc. can be made without departing from the gist of the invention. These embodiments and their modifications are included in the scope and gist of the invention, and are included in the invention described in the claims and the equivalent scope thereof.

Claims

1. (a)A pyrimidylpyrazole compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof; 【Chemical Formula 1】 (In the general formula (1), R １ , R ３ , R ４ , and R ６ each independently represent an alkyl group having 1 to 3 carbon atoms, and R ２ and R ５ each independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.) (b)At least one selected from the group consisting of polyoxyethylene dialkyl esters and polyoxyethylene dialkyl ethers represented by the following general formula (2); [Chemical 2] (However, in the general formula (2), R ７ and R ８ each independently represent a linear aliphatic acid residue or a linear aliphatic alcohol residue having 16 to 24 carbon atoms, and n represents an integer of 4 to 15.) (c)At least one selected from the group consisting of polyoxyethylene alkyl esters and polyoxyethylene alkyl ethers represented by the following general formula (3); 【Chemical Formula 3】 (However, in the general formula (3), R ９ represents a linear aliphatic residue, a linear aliphatic acid residue, or a linear aliphatic alcohol residue having 16 to 24 carbon atoms, and n represents an integer of 5 to 30.) A cosmetic characterized by containing the above components.

2. R in the (a) pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof ２ and R ５ are hydrogen atoms, and the cosmetic according to claim 1.

3. R in the above-mentioned (a) pyrimidylpyrazole compound represented by the general formula (1) or a pharmacologically acceptable salt thereof １ , R ３ , R ４ , and R ６ is a methyl group, The cosmetic according to claim 1 or 2.

4. The cosmetic according to Claim 1, wherein the content of the pyrimidylpyrazole compound represented by the general formula (1) or the pharmacologically acceptable salt thereof in the component (a) is 0.1% by mass to 1% by mass.

5. The cosmetic according to Claim 1, wherein the content of at least one selected from the group consisting of the polyoxyethylene dialkyl ester and the polyoxyethylene dialkyl ether represented by the general formula (2) in the component (b) is 15% by mass to 45% by mass based on the total content of the component (b) and the component (c).

6. The cosmetic according to Claim 1, further containing (d) water, wherein the content of the water in the component (d) is 20% by mass to 80% by mass.

Images