Medicament filling system

Abstract

To provide a syringe assembly that has efficient and improved accuracy of a medicament transferred.SOLUTION: A syringe assembly (2) that provides haptic feedback during dose setting comprises a syringe (10) and a dose selector. The syringe includes: a barrel (12) configured to carry a medicament; and a plunger (14) having a plunger head (16) disposed on a proximal end of the plunger, the plunger communicating with the barrel, the plunger including a plurality of axial ribs (24) extending along a length of the plunger and a notch 26 disposed in each axial rib. The dose selector (70) is disposed around the barrel, and passes through one of the notches to set a dose.SELECTED DRAWING: Figure 6

Description

[Technical Field]

[0001] Various exemplary embodiments of the present invention relate to a device for filling a delivery device with a pharmaceutical agent (drug). [Background technology]

[0002] This application claims the benefit under 35 USC § 119(e) of U.S. Provisional Patent Application Serial No. 62 / 908,377, filed September 30, 2019, which is incorporated herein by reference in its entirety.

[0003] Systems such as delivery devices and syringe assemblies are typically used to inject medications such as insulin into patients. However, inefficiencies and inconveniences can arise. These challenges include providing dosage feedback, minimizing air ingress into the delivery device, preventing medication backflow in the delivery device during and after the filling step, and improving safety, handling, and stability. Summary of the Invention

[0004] One aspect of the present invention is to provide a syringe assembly that locks the syringe to prevent backflow of medication. After the delivery device is filled with medication, the syringe plunger is configured to prevent backflow of medication from the delivery device into the syringe. Such an assembly provides efficient and improved accuracy of medication transferred to the delivery device.

[0005] Another aspect of the present invention provides a syringe assembly that provides tactile feedback during dose setting. Such a configuration provides user confirmation of the specified dose setting, prevents unintentional locking, and minimizes user confusion.

[0006] In another aspect of the invention, the fluid transfer device engages with a syringe to provide different fluid paths for aspirating and injecting medication. Such a configuration prevents backflow of medication from the delivery device into the syringe, avoids the use of locking mechanisms, and provides efficiency and improved accuracy of medication transferred to the delivery device without changing the syringe.

[0007] The foregoing and / or other aspects of the present invention can be accomplished by providing a syringe assembly for locking a syringe to prevent backflow of a medicament, the syringe assembly including: a barrel configured to carry a medicament; a plunger in communication with the barrel; a plunger head disposed at a proximal end of the plunger; and a locking assembly disposed about the barrel, the locking assembly preventing the plunger from moving away from the barrel to draw the medicament into the barrel.

[0008] The foregoing and / or other aspects of the present invention can be further accomplished by providing a syringe assembly that provides tactile feedback during dose setting, the syringe assembly comprising: a syringe including a barrel configured to carry a medicament; and a plunger having a plunger head disposed at a proximal end of the plunger, the plunger in communication with the barrel, the plunger including a plurality of axial ribs extending along the length of the plunger, a notch disposed in each axial rib, and a dose selector disposed about the barrel, the dose selector passing through one of the notches to set the dose.

[0009] The foregoing and / or other aspects of the present invention can also be achieved by providing a fluid transfer device that prevents backflow of a medication, the fluid transfer device including: a barrel configured to carry the medication; a plunger connected to the barrel; and a vial adapter including: a first needle cannula that allows the medication to exit the fluid transfer device; a second needle cannula, the second needle cannula having a length shorter than the first needle cannula, that allows the medication to enter the fluid transfer device; a first one-way valve connected to the first needle cannula; and a second one-way valve connected to the second needle cannula.

[0010] The foregoing and / or other aspects of the present invention may additionally be achieved by providing a fluid transfer device that prevents backflow of a medication, the fluid transfer device comprising: a first needle cannula that allows the medication to exit the fluid transfer device; a second needle cannula that allows the medication to enter the fluid transfer device, the second needle cannula being shorter in length than the first needle cannula and positioned within the first needle cannula; and a two-way valve connected to the first and second needle cannula, wherein the second needle cannula is configured to withdraw the medication from a vial, and the first needle cannula transfers the medication into the delivery device when the fluid transfer device is engaged with the delivery device.

[0011] Additional and / or other aspects and advantages of the present invention will be set forth in the description that follows, or will be obvious from the description, or may be learned by practice of the invention. [Brief explanation of the drawings]

[0012] The above aspects and features of the present invention will become more apparent from the following description of exemplary embodiments of the invention, which proceeds with reference to the accompanying drawings. [Figure 1] FIG. 1 illustrates a first exemplary embodiment of a left perspective view of a syringe assembly. [Figure 2] FIG. 2 illustrates a second exemplary embodiment of a right perspective view of a syringe assembly with a plunger head platform. [Figure 3] FIG. 3 illustrates a third exemplary embodiment of a side view of a syringe assembly having a dial dose and position indicator. [Figure 4] 4 is a perspective view of the syringe assembly of FIG. 3 in an unlocked position. [Figure 5] 5 is a perspective view of the syringe assembly of FIG. 3 in a locked position. [Figure 6] FIG. 6 illustrates a fourth exemplary embodiment of a right perspective view of a syringe assembly that provides tactile feedback. [Figure 7] FIG. 7 is a cross-sectional view of the syringe assembly taken along line AA in FIG. [Figure 8] FIG. 8 illustrates a fifth exemplary embodiment of a side view of a syringe assembly engaging a plunger head platform. [Figure 9] FIG. 9 illustrates a sixth exemplary embodiment of a cross-sectional view of a fluid transfer device engaged with a syringe. [Figure 10] FIG. 10 is a cross-sectional view of the fluid transfer device of FIG. 9 engaged with a vial. [Figure 11] FIG. 11 is a cross-sectional view of the fluid transfer device of FIG. 9 engaged with an insulin delivery device. [Figure 12] FIG. 12 illustrates a seventh exemplary embodiment of a cross-sectional view of a fluid transfer device depicting a drug. [Figure 13] FIG. 13 is a cross-sectional view of the fluid transfer device of FIG. 12 showing the ejection of the agent. [Figure 14] FIG. 14 is a cross-sectional view of the fluid transfer device of FIG. 12 illustrating the agent and providing a vent passageway. [Figure 15] FIG. 15 is a cross-sectional view of the fluid transfer device of FIG. 12 showing the ejection of medication and the provision of a vent passageway. DETAILED DESCRIPTION OF THE INVENTION

[0013] FIG. 1 illustrates a syringe assembly 2 according to one embodiment. The syringe assembly 2 includes a syringe 10 having a barrel 12, a plunger 14, a plunger head 16, and a needle (not shown), as conventionally understood by those skilled in the art. Specifically, the barrel 12 carries a medication, and the plunger 14 is disposed within the barrel 12 to move the medication into and out of the barrel 12. The plunger head 16 is connected to the proximal end of the plunger 14 and allows a user to move the plunger 14 to perform medication filling and dispensing operations. The needle receives the medication from a vial and dispenses the medication into an insulin delivery device.

[0014] Syringe assembly 2 further includes a locking assembly 50 that locks plunger 14 of syringe 10 after the medication has been dispensed to advantageously prevent backflow of the medication into barrel 12. Locking assembly 50 includes a hook 52, an arm 54, a base 56, a pivot shaft 58, a spring member 60, and a button 62.

[0015] Hook 52 is disposed at the proximal end of arm 54 and includes a cantilevered surface configured to engage the top surface of plunger head 16 when medication is dispensed from barrel 12 of syringe 10. Base 56 is secured to and surrounds barrel 12. Pivot shaft 58 is disposed on a side of base 56 and is rotatable. Pivot shaft 58 engages a central portion of arm 54 to allow hook 52 to rotate.

[0016] The distal end of arm 54 includes a spring member 60 and a button 62. Spring member 60 contacts barrel 12 on one side of arm 54, and button 62 is located on the opposite side of arm 54 to provide a user-depressible surface. Hook 52 is configured to rotate about a pivot shaft 58 located between button 62 and hook 52. Pivot shaft 58 allows arm 54 to rotate between an engaged position and a disengaged position upon actuation of button 62 by a user.

[0017] Specifically, when medication from syringe 10 is dispensed, plunger 14 is in a distal position. The natural state of locking assembly 50 positions hook 52 over plunger head 16 to lock movement of plunger 14. In this state, button 62 is in a free or released state, and spring member 60 pushes button 62 (first compression force) to provide maximum engagement of hook 52 with plunger head 16.

[0018] To unlock the syringe 10 from the locking assembly 50, the user depresses the button 62 against the spring force (second compression force) of the spring member 60. This causes the arm 54 to rotate about the pivot shaft 58, disengaging the hook 52 from the plunger head 16. The second compression force is greater than the first compression force.

[0019] When a syringe conventionally fills an insulin delivery device, the user must simultaneously hold the plunger head and remove the syringe from the insulin delivery device to avoid backflow of medication into the syringe 10. The locking assembly 50 disclosed herein advantageously locks the plunger head 16 after medication has been dispensed into the insulin delivery device. In this way, no medication will backflow into the syringe 10 and the user can comfortably remove the syringe 10 from the insulin delivery device. The locking assembly 50 also advantageously allows the user to unlock the syringe 10 for use if the syringe 10 has been accidentally locked.

[0020] FIG. 2 illustrates a syringe assembly 4 according to a second embodiment. This embodiment discloses a syringe 10 and locking assembly 50 similar to those described above, with the following modifications: The plunger head 16 of the syringe 10 includes a plunger head platform 20. The platform 20 is positioned below the plunger head 16 such that a gap exists between the two features. The platform 20 is preferably molded as part of the plunger 14, but alternatively, can be a separate part attached to the plunger 14. A hook 52 of the locking assembly 50 is advantageously configured to engage the gap to lock the plunger 14 after the medication has been dispensed from the barrel 12 of the syringe 10.

[0021] Additionally, hook 52 includes a plurality of protrusions 66 that provide a depressible surface. Thus, a user can advantageously apply force to hook 52 where protrusions 66 are located, or to button 62 to move hook 52 from an engaged, locked position to a disengaged, unlocked position. This configuration in this embodiment advantageously provides a full surface on plunger head 16 available for a user to manipulate when engaging and disengaging lock assembly 50.

[0022] 3-5 illustrate a syringe assembly 6 according to a third embodiment. This embodiment discloses a syringe 10 and locking assembly 50 similar to those described above, with the following modifications: The plunger head 16 includes a dial dose 18. The dial dose 18 indicates a dosage unit amount. Specifically, the plunger head 16 is rotated to set the desired dose identified by the dial dose 18.

[0023] Additionally, lock assembly 50 includes a position indicator 64 shaped as an arrow. Position indicator 64 advantageously cooperates with dial dose 18 to identify the dose position of plunger head 16. As shown in FIG. 5 , position indicator 64 points to the particular dosage represented by dial dose 18 set by the user via rotation of plunger head 16. Button 62 on lock assembly 50 also includes a protrusion 66 that provides a friction surface for the user to depress button 62.

[0024] In operation, Figures 3 and 4 illustrate the unlocked position of the locking assembly 50, while Figure 5 illustrates the locked position. In the unlocked position, the plunger 14 is free to move within the barrel. In the locked position, the plunger 14 cannot move because the hook 52 engages the platform 20 to prevent movement.

[0025] 6 and 7 illustrate a syringe assembly 8 according to a fourth embodiment. This embodiment discloses a syringe 10 similar to that described above, with the following modifications: This embodiment incorporates a dose selector 70 with the syringe 10 to advantageously provide tactile feedback to the user when setting the dose.

[0026] The plunger 14 of the syringe 10 is modified to cooperate with the dose selector 70. Specifically, the plunger 14 includes a plurality of axial ribs 24 extending along the length of the plunger 14. The axial ribs 24 provide stability and rigidity to the plunger 14. A curved recess 28 is disposed between each adjacent axial rib 24.

[0027] Figure 6 shows that the vertical portions of the plurality of axial ribs 24 include notches 26. A cross section of the plunger 14 at the notches 26 is shown in Figure 7. The notches 26 advantageously provide a smooth, raised surface around the plunger 14. The notches 26 also advantageously provide a continuous surface between adjacent curved recesses 28.

[0028] 6 further illustrates dose selector 70, which includes arm 72, position indicator 74, base 76, and tab 78. Base 76 is secured to and surrounds barrel 12 of syringe 10. Arm 72 extends upwardly from base 76 and includes position indicator 74, such as an arrow that indicates the set dose. Base 76 and position indicator 74 are also similarly described above for various embodiments of the locking assembly.

[0029] Tab 78 is an inwardly extending member located on the interior surface of base 76. Tab 78 cooperates with plunger 14 and notch 26. Specifically, plunger 14 can only move vertically when tab 78 is located between axial ribs 24, within curved recess 28, and outside notch 26 of plunger 14. A user places tab 78 in a vertical position on plunger 14 where notch 26 is positioned to rotate plunger 14 and adjust the dosage.

[0030] As the user rotates plunger 14 to set a dose, a detent or force is advantageously provided each time tab 78 encounters notch 26 in one of axial ribs 24. As shown in FIG. 7, this force or detent occurs because of contact between axial rib 24 and tab 78 within notch 26. This detent or force is tactile feedback indicating that the dosage has been changed. In this position, plunger 14 is also locked to prevent vertical movement.

[0031] 7, when the tab 78 is positioned between two of the axial ribs 24, there is no contact and therefore no detent or force is provided, i.e., the tab 78 does not contact the curved recess 28. Thus, the user advantageously experiences alternative pressure (tactile feedback) when rotating between dose setting positions.

[0032] FIG. 8 illustrates a syringe assembly 9 according to a fifth embodiment. This embodiment discloses a syringe 10 and lock assembly 50 similar to those described above, with the following modifications. Specifically, the plunger head platform 20 includes a rounded circumferential surface that engages the hook 52. More specifically, the hook 52 includes a hook recess 53 that is contoured to engage and receive the rounded circumferential surface of the plunger head platform 20. Such a configuration advantageously provides a more secure and smooth engagement of the hook 52 with the platform 20 when the lock assembly 50 is in the locked position.

[0033] Figures 9-11 show cross-sectional views of a fluid transfer device 120 attached to a syringe 121 according to a fifth embodiment. Figure 10 illustrates the fluid transfer device 120 engaged with a vial 100 to receive a medication. Figure 11 illustrates the fluid transfer device 120 engaged with an insulin delivery device (IDD) 110 to transfer a medication. Further details of the fluid transfer device 120 are provided below.

[0034] Syringe 121 is commonly understood by those skilled in the art and includes, for example, a barrel 122 that carries a medication and a plunger 124 disposed in barrel 122 that aspirates and dispenses the medication. Syringe 121 is configured to engage with and establish fluid communication with vial adapter 130 of fluid transfer device 120. In an alternative embodiment, fluid transfer device 120 includes barrel 122 and plunger 124 in fluid communication with vial adapter 130.

[0035] Vial adapter 130 includes a first needle cannula 132, a second needle cannula 134, a first one-way valve 136, and a second one-way valve 138. First needle cannula 132 is used to transfer medication from barrel 122 to insulin delivery device 110, as shown in FIG. 11. Second needle cannula 134 is used to receive medication from vial 100, as shown in FIG. 10.

[0036] The first needle cannula 132 is advantageously longer than the second needle cannula 134 so that only the first needle cannula 132 engages with the insulin delivery device 110. As shown in FIG. 11 , the second needle cannula 132 is too short to engage with the insulin delivery device 110.

[0037] Meanwhile, second needle cannula 134 is advantageously shorter than first needle cannula 132 in order to receive more medication from vial 100. FIG. 10 shows both first needle cannula 132 and second needle cannula 134 positioned within vial 100. However, the distal end of second needle cannula 134 is closer to the bottom of vial 100. As medication leaves vial 100, the associated fluid level drops within vial 100. Having a short needle cannula 134 advantageously optimizes the amount of medication that can be removed from vial 100.

[0038] First one-way valve 136 controls the flow of medication through first needle cannula 132 so that medication within barrel 122 can only exit through first needle cannula 132. That is, first one-way valve 136 does not allow first needle cannula 132 to receive medication into barrel 122.

[0039] Meanwhile, second one-way valve 138 controls the flow of medication through second needle cannula 134 so that medication can only enter through second needle cannula 134 to fill barrel 122. Conversely, second one-way valve 138 does not allow second needle cannula 134 to dispense medication from barrel 122.

[0040] The fluid transfer device 120 of this embodiment provides an alternative means for preventing backflow of medication from the insulin delivery device 110 to the syringe 121. To achieve this benefit, the fluid transfer device 120 advantageously provides a separate fluid path without using a plunger locking mechanism or the need to manually hold the syringe plunger after fluid delivery.

[0041] 12-15 show cross-sectional views of a fluid transfer device 220 according to a sixth embodiment. Fluid transfer device 220 includes a vial adapter 230, a first needle cannula 232, a second needle cannula 234, a two-way valve 236, a vent membrane 239, and a syringe adapter 242. FIG. 14 shows that vial adapter 230 is preferably engaged with vial 200 via a snap-lock engagement, although other means are contemplated herein. Syringe adapter 242 is configured to engage with a syringe (not shown), preferably via a luer lock, although other means are contemplated herein.

[0042] As also described above, the first needle cannula 232 is used to transfer medication from a syringe to the insulin delivery device 210, as shown in Figure 15. The second needle cannula 234 is used to receive medication from the vial 200, as shown in Figure 14.

[0043] The first needle cannula 232 is advantageously longer than the second needle cannula 234 so that only the first needle cannula 232 engages with the insulin delivery device 210. The bottom surface of the vial adapter 230 advantageously controls the insertion depth of the first needle cannula 232 within the insulin delivery device 210. As shown in FIG. 15 , the second needle cannula 232 is too short to engage with the insulin delivery device 210. Specifically, the second needle cannula 232 does not extend beyond the bottom surface of the vial adapter 230 to advantageously ensure that fluid communication to the insulin delivery device 210 is not established.

[0044] Meanwhile, second needle cannula 234 is advantageously shorter than first needle cannula 232 to receive more medication from vial 200. FIG. 14 shows that the distal end of second needle cannula 234 is closer to the bottom of vial 200. As medication leaves vial 200, the associated fluid level drops within vial 200. Having a short second needle cannula 234 optimizes the amount of medication removed from vial 200. The depth of the cavity within vial adapter 230 that engages vial 200 advantageously controls the insertion depth of second needle cannula 234.

[0045] Additionally, first needle cannula 232 is advantageously disposed within second needle cannula 234. Such a configuration optimizes space, provides a simple design, and continues to accommodate different fluid pathways, as described in more detail below.

[0046] The two-way valve 236 is preferably a combination duckbill and umbrella valve. However, other combinations of valves can be used to achieve the functional advantages described herein. The two-way valve 236 controls the flow of medication through the first needle cannula 232 so that the medication in the syringe can only exit through the first needle cannula 232. That is, the two-way valve 236 does not allow the first needle cannula 232 to receive medication into the syringe.

[0047] The two-way valve 236 also controls the flow of medication through the second needle cannula 234 so that medication can only enter through the second needle cannula 234 to fill the syringe. Similarly, the two-way valve 236 does not allow the second needle cannula 234 to dispense medication from the syringe.

[0048] In view of the above, the two-way valve 236 advantageously controls the transfer of medication. However, the two-way valve 236 does not control the exchange of air. Further description of the airflow path 254 within the fluid transfer device 220 is provided below.

[0049] 12-15 also show vent membrane 239, which connects to airflow pathway 254, as well as medication inlet pathway 250 and medication outlet pathway 252. FIG. 12 shows a syringe being filled with medication. Specifically, medication inlet pathway 250 is illustrated in a manner in which medication enters the distal end of second needle cannula 234, is routed in a path offset from the centerline of vial adapter 230 to two-way valve 236, and ultimately into syringe adapter 242 to fill the syringe.

[0050] 14 shows the medication inlet pathway 250 when the vial adapter 230 is engaged with the vial 200. The vent membrane 239 cooperates with the transfer of medication from the vial 200 to the syringe and is located upstream of the two-way valve 236.

[0051] Specifically, as the medication exits vial 200, air advantageously enters vial 200 via airflow path 254 and vent membrane 239. Airflow path 254 is upstream from two-way valve 236 and includes a path through first needle cannula 232. In this manner, no vacuum is created within vial 200 and the pressure within vial 200 equalizes with environmental pressure.

[0052] 13 and 15 show a drug exit pathway 252 that allows drug to exit the syringe and enter the insulin delivery device 210. The drug exit pathway 252 travels through the two-way valve 236, through the centerline of the fluid transfer device 220, and through the first needle cannula 232 before finally entering the insulin delivery device 210.

[0053] Meanwhile, as described above, the same airflow path 254 through the first needle cannula 232 and vent membrane 239 is used to remove air from the insulin delivery device 220. Advantageously, no vacuum is created in the insulin delivery device 220, and the pressure within the insulin delivery device 220 equalizes with environmental pressure.

[0054] The fluid transfer device 220 of this embodiment provides an alternative means for preventing backflow of medication from the insulin delivery device 210 back into the syringe. To achieve this benefit, the fluid transfer device 220 advantageously provides separate fluid and air paths without using a plunger locking mechanism or the need to manually hold the syringe plunger after fluid delivery.

[0055] The foregoing detailed description of certain exemplary embodiments is provided to illustrate the principles of the invention and its practical application, thereby enabling those skilled in the art to understand the invention in various embodiments and with various modifications as appropriate for a particular use contemplated. This description is not necessarily intended to be exhaustive or to limit the invention to the detailed embodiments described. Additionally, any of the embodiments, features, and / or elements disclosed herein may be combined with one another to form various additional combinations not specifically disclosed, so long as the combined embodiments, features, and / or elements are not mutually inconsistent. Accordingly, additional embodiments are possible and are intended to be encompassed within the scope of this specification and the present invention. This specification describes specific examples for achieving more general goals that may be achieved in other ways.

[0056] As used in this application, the terms "front," "back," "top," "bottom," "upward," "downward," and other directional descriptors are intended to facilitate the description of exemplary embodiments of the present invention and are not intended to limit the structures of exemplary embodiments of the present invention to any particular location or orientation. Terms of degree, such as "substantially" or "approximately," will be understood by those skilled in the art to refer to a reasonable range around a given value, e.g., the typical tolerance range associated with the manufacture, assembly, and use of the described embodiments.

Claims

1. 1. A syringe assembly that provides tactile feedback during dose setting, comprising: a barrel configured to carry the medicament; and A plunger in communication with the barrel, the plunger having a plunger head disposed at a proximal end of the plunger, the plunger comprising: a plurality of axial ribs extending along the length of the plunger; a notch disposed in each axial rib; a syringe including a dose selector disposed about the barrel, the dose selector passing through one of the notches to set a dose; A syringe assembly comprising:

2. the plunger includes a curved recess between each of the notches, the curved recess being disposed between adjacent axial ribs of the plurality of axial ribs; the dose selector engages and disengages the notch to provide tactile feedback regarding the dose setting. The syringe assembly of claim 1 .

3. the plunger head includes a dial dose to indicate a dose setting; the dose selector includes an arm having a position indicator that cooperates with the dial dose to identify and set a desired dose; 3. The syringe assembly of claim 2.

4. the dose selector having a base secured to the barrel; the arm extends upwardly from the base; a tab disposed on an inner surface of the base for engaging and disengaging with the notch; 4. The syringe assembly of claim 3.

5. 1. A fluid transfer device engageable with a syringe having a barrel configured to carry a medicament and a plunger connected to the barrel, the fluid transfer device preventing backflow of the medicament into the syringe, comprising: a first needle cannula that allows the medicament to exit the fluid transfer device; a second needle cannula that allows the medication to enter the fluid transfer device, the second needle cannula having a length that is shorter than the first needle cannula; a first one-way valve connected to the first needle cannula; and a second one-way valve connected to the second needle cannula. Vial adapter comprising A fluid transfer device comprising:

6. the medication is drawn from the vial through the second needle cannula; When the fluid transfer device is engaged with a delivery device, the first needle cannula is in fluid communication with the delivery device for transferring a medicament. The fluid transfer device of claim 5 .

7. the first one-way valve prevents pressure within the delivery device from forcing the medication back into the fluid transfer device; The fluid transfer device of claim 5 .

8. When the fluid transfer device is engaged with a delivery device, the second needle cannula is disengaged from the delivery device. The fluid transfer device of claim 5 .

9. 1. A fluid transfer device for preventing backflow of a drug, comprising: a first needle cannula that allows the medicament to exit the fluid transfer device; a second needle cannula that allows the medicament to enter the fluid transfer device, the second needle cannula having a shorter length than the first needle cannula, the second needle cannula being disposed within the first needle cannula; and a two-way valve connected to the first needle cannula and the second needle cannula; the second needle cannula is configured to withdraw the medication from a vial; When the fluid transfer device is engaged with a delivery device, the first needle cannula transfers a medicament to the delivery device. Fluid transfer devices.

10. the two-way valve comprises a combination duckbill and umbrella valve; The fluid transfer device of claim 9.

11. a vent membrane that supplies air to the vial when the medication is withdrawn and releases air from the delivery device when the medication is delivered to the delivery device. The fluid transfer device of claim 9.

12. the two-way valve prevents backflow of the medication as it is delivered to the delivery device; The fluid transfer device of claim 9.

Images