Compositions

Abstract

To provide a means to suppress stickiness even when a certain amount of dipotassium glycyrrhizinate is compounded.SOLUTION: Provided is a composition containing (A) dipotassium glycyrrhizinate and (B) polyglyceryl-10 (eicosanedioate / tetradecanedioate), the content of (A) being 0.2 to 1.0 mass% based on the total mass of the composition.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a composition containing dipotassium glycyrrhizinate. [Background technology]

[0002] Dipotassium glycyrrhizinate has anti-inflammatory properties and is a widely used ingredient in topical skin preparations intended to improve rough skin, etc. It is also known as an ingredient that improves wrinkles, one of the symptoms of aging, and is incorporated into topical skin preparations such as cosmetics (Patent Document 1). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Publication No. 2019-108278 Summary of the Invention [Problem to be solved by the invention]

[0004] Compositions containing dipotassium glycyrrhizinate tend to feel sticky. In view of the above circumstances, an object of the present invention is to provide a means for suppressing stickiness even when a certain amount of dipotassium glycyrrhizinate is blended. [Means for solving the problem]

[0005] The present inventors have conducted research to solve the above problems and have found that the above problems can be solved by combining dipotassium glycyrrhizinate with a specific ester oil, thereby completing the present invention. That is, the present invention is as follows.

[0006] [1] A composition comprising (A) dipotassium glycyrrhizinate and (B) polyglyceryl-10 (eicosanedioate / tetradecanedioate), A composition in which the content of (A) is 0.2 to 1.0% by mass based on the total mass of the composition. [2] The composition according to [1], wherein the content of (B) is 0.0001 to 5% by mass based on the total mass of the composition. [3] The composition according to [1] or [2], wherein the mass ratio of the contents of component (A) and component (B) is 1:10 to 100:1. [4] The composition according to any one of [1] to [3], which is an external preparation for skin. [Effects of the Invention]

[0007] According to the present invention, it is possible to provide a composition that suppresses sticky feeling even when a certain amount of dipotassium glycyrrhizinate is blended. Furthermore, the composition of the present invention suppresses the squeaky feeling and provides a moist / fresh feeling, and therefore has an excellent feel when applied to the skin. Furthermore, in the composition of the present invention, precipitation of dipotassium glycyrrhizinate crystals is also inhibited. DETAILED DESCRIPTION OF THE INVENTION

[0008] The present invention will be described below. The composition of the present invention contains (A) dipotassium glycyrrhizinate and (B) polyglyceryl-10 (eicosanedioate / tetradecanedioate).

[0009] (A) Dipotassium glycyrrhizinate may be an artificially synthesized substance or may be derived from natural products such as plants. Dipotassium glycyrrhizinate may also be provided in the form of a plant extract containing it.

[0010] Dipotassium glycyrrhizinate may be a commercially available product, or may be extracted from, for example, a plant of the genus Glycyrrhiza in the family Fabaceae, such as Glycyrrhiza glauca (G. glabra), Glycyrrhiza uralensis, Glycyrrhiza inflata, etc.

[0011] The method for extracting dipotassium glycyrrhizinate from a plant of the genus Glycyrrhiza in the family Leguminosae is not particularly limited, and can be a conventional extraction method, i.e., adding 1 to 20 times the amount of water or a lower alcohol such as ethanol as a solvent to the plant body or a processed product thereof, stirring as desired, and immersing the plant body or a processed product thereof for several days at room temperature or for several hours at a temperature near the boiling point, removing insoluble matter by filtration or the like, and then, if desired, removing the solvent by vacuum distillation or the like, and, in some cases, purifying and fractionating the product by column chromatography or the like, and then using the product. A preferred example of a plant part for preparing a plant extract is the rhizome.

[0012] In the composition of the present invention, the content of component (A) is 0.2 to 1.0% by mass relative to the total composition. This range reduces stickiness, provides an excellent feel during use, such as a non-greasy feeling, a moist feeling, and a fresh feeling, and also suppresses crystal precipitation. A content of component (A) less than 0.2% by mass makes it difficult to achieve the desired effects, while a content exceeding 1.0% by mass reduces the desired effects and limits the flexibility of formulation of the composition. The content of component (A) may be 0.2% by mass or more, 0.3% by mass or more, or 0.5% by mass or more, or 1.0% by mass or less, 0.8% by mass or less, or 0.7% by mass or less, or any combination thereof, consistent with the total composition. The content of component (A) may be 0.2 to 1.0% by mass, 0.3 to 0.8% by mass, or 0.5 to 0.7% by mass relative to the total composition.

[0013] The polyglyceryl-10 (eicosanedioate / tetradecanedioate) (B) contained in the composition of the present invention is not particularly limited as long as it is one that is normally contained in cosmetics, and commercially available products can be used. Commercially available products of polyglyceryl-10 (eicosanedioate / tetradecanedioate) include, for example, Neosolue-AquaS (manufactured by Nippon Fine Chemical Co., Ltd.).

[0014] The content of component (B) in the composition of the present invention is not particularly limited, and may be, for example, 0.0001% by mass or more, 0.0005% by mass or more, or 0.001% by mass or more, or 5% by mass or less, 2% by mass or less, or 1% by mass or less, or any compatible combination thereof, relative to the total mass of the composition. Furthermore, the content of component (B) may be 0.0001 to 5% by mass, 0.0005 to 2% by mass, or 0.001 to 1% by mass, relative to the total mass of the composition. By using the component in this range, the cosmetic composition will feel less sticky after application, and it is also easier to obtain a better feel when used, such as no squeaky or dry feeling, and formulation stability.

[0015] In the composition of the present invention, the mass ratio of the contents of component (A) and component (B) is not particularly limited, but from the viewpoints of usability and formulation stability, it is preferably, for example, 1:10 to 100:1, and more preferably 1:5 to 10:1.

[0016] The formulation of the composition of the present invention is not particularly limited, and may be an emulsion, aqueous formulation, oil-based formulation, oil gel formulation, etc. In the case of an emulsion, it may be a water-in-oil type or an oil-in-water type, and may be a W / O type, an O / W / O type, a (W1+W2) / O type, an O / W type, a W / O / W type, or an (O1+O2) It may be a / W type or the like.

[0017] When the composition of the present invention is in the form of an emulsion, it usually contains an aqueous phase component and an oil phase component. The aqueous phase component may be any component that dissolves in water at 25 to 90° C. The oil phase component is not limited to oils and generally includes powders, etc., and may be any component that undergoes phase separation from water after being suspended in water at 25 to 90° C. and left to stand for 1 hour. When the composition of the present invention is in the form of an emulsion, the mass ratio of the contents of the aqueous phase component to the oil phase component is not particularly limited, but is preferably 30:70 to 90:10, more preferably 60:40 to 85:15.

[0018] The composition of the present invention has an excellent feel when applied to the skin, and is therefore suitable for use as an external skin preparation. External skin preparations can be used, for example, in the form of cosmetics, including pharmaceuticals and quasi-drugs. Cosmetics are particularly preferred. Specific examples of cosmetics include skin care cosmetics such as lotions, emulsions, and creams; makeup cosmetics such as makeup bases and foundations; and sunscreen cosmetics such as sunscreen emulsions and sunscreen creams. Furthermore, the cosmetic form can be selected from a variety of forms, including liquid, emulsion, and cream.

[0019] The composition of the present invention may contain optional components other than the above components, as long as the effects of the composition are not impaired. The optional components are not particularly limited and can be any known component used in the field of compositions such as cosmetics. One or a combination of two or more optional components can be used in the present invention.

[0020] Examples of such optional components include oils, powders, alcohols, ethers, moisturizers, surfactants, sequestering agents, pearlescent agents, amino acids, organic amines, polymer emulsions, pH adjusters, vitamins, antioxidants, preservatives, water-soluble polymers, fragrances, and various active ingredients.

[0021] Examples of oil agents include silicone oil, polar oil, natural oil, and hydrocarbon.

[0022] Silicone oils include dimethylpolysiloxane (dimethicone), cyclopentasiloxane, decamethylcyclopentasiloxane, caprylyl methicone, trimethylsiloxysilicate, and the like.

[0023] Polar oils include synthetic ester oils such as isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid esters, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, diisostearyl malate, glyceryl di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentaneerythritol tetra-2-ethylhexylate, Glyceryl 2-ethylhexanoate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleic acid oil, cetostearyl alcohol, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroy Examples of suitable esters include 2-octyldodecyl-L-glutamate, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, isononyl isononanoate, ethyl acetate, butyl acetate, amyl acetate, and triethyl citrate.

[0024] Examples of natural oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, camellia oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, Japanese kaya oil, rice bran oil, Chinese tung oil, Japanese tung oil, jojoba oil, germ oil, sunflower oil, triglycerin, glyceryl trioctanoate, and glyceryl triisopalmitate.

[0025] Examples of hydrocarbon oils include isododecane, isohexadecane, squalane, hydrogenated poly(C6-12)olefin, and hydrogenated polyisobutene.

[0026] The powder may be spherical, needle-like, plate-like, or the like, and its shape is not particularly limited. Examples of the powder include inorganic white pigments (e.g., titanium dioxide, zinc oxide, etc.); inorganic red pigments (e.g., iron oxide (red iron), iron titanate, etc.); inorganic brown pigments (e.g., γ-iron oxide, etc.); inorganic yellow pigments (e.g., yellow iron oxide, ochre, etc.); inorganic black pigments (e.g., black iron oxide, low-order titanium oxide, etc.); inorganic purple pigments (e.g., mango violet, cobalt violet, etc.); inorganic green pigments (e.g., chromium oxide, hydroxide chromium chloride, cobalt titanate, etc.); inorganic blue pigments (e.g., ultramarine, iron blue, etc.); pearl pigments (e.g., titanium dioxide-coated mica, titanium dioxide-coated bismuth oxychloride, titanium dioxide-coated talc, colored titanium dioxide-coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (e.g., aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium, or aluminum lake (e.g., Red 201, Red 202, Red 204, Red Organic pigments such as Color No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, and Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow 202, Yellow No. 203, Green No. 3, and Blue No. 1; natural pigments (e.g., chlorophyll, beta-carotene, etc.); inorganic powders (e.g., talc, kaolin, Mica, sericite (sericite), muscovite, phlogopite, synthetic mica, lepidolite, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, alumina, zeolite, barium sulfate, calcined calcium sulfate (calcined gypsum), calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, boron nitride, etc.);Examples of suitable organic powders include polyamide resin powder (nylon powder), polyethylene powder, poly(methyl meth)acrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, silicone resin powder, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, and silicone composite spherical powders (e.g., vinyl dimethicone / methicone silsesquioxane crosspolymer, diphenyl dimethicone / vinyl diphenyl dimethicone / silsesquioxane crosspolymer, polysilicone-22, polysilicone-1 crosspolymer, etc.); metal soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate); and organically modified clay minerals (e.g., organically modified bentonite, organically modified hectorite, etc.).

[0027] Examples of alcohols include ethanol, isopropanol, cetanol, batyl alcohol, behenyl alcohol, palmitoleic alcohol, heptadecanol, 1-heptadecanol, stearyl alcohol, isostearyl alcohol, and elaidyl alcohol. Monohydric alcohols such as oleyl alcohol, linoleyl alcohol, elaidolinoleyl alcohol, linolenyl alcohol, elaidolinolenyl alcohol, ricinoleyl alcohol, nonadecyl alcohol, arachidyl alcohol, heneicosanol, and erucyl alcohol; ethylene glycol, 1,3-butylene glycol, 1,3-propanediol, trimethylene glycol, 1,2-butylene glycol, propylene glycol, dipropylene glycol, propanediol, 1,2-pentanediol, 3-methylpropanol, ... Dihydric alcohols such as 1,3-butyl-1,3-butanediol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene glycol, 2-butene-1,4-diol, isopentyldiol, hexylene glycol, and octylene glycol; trihydric alcohols such as trimethylolpropane; tetrahydric alcohols such as pentaerythritol; pentahydric alcohols such as xylitol; polyhydric alcohol polymers such as triglycerin, tetraglycerin, and polyglycerin; sugar alcohols such as starch-decomposed sugar-reduced alcohols; polyglycerin; alcohol alkyl ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono-2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, and ethylene glycol isopropyl ether; alcohol alkyl ethers such as diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, and dipropylene glycol butyl ether; glycerin monoalkyl ethers such as xyl alcohol, selachyl alcohol, and batyl alcohol; Alcohol polymers such as diethylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, and polyethylene glycol; Examples include glycerol; tetrahydrofurfuryl alcohol; POE-tetrahydrofurfuryl alcohol; POP-butyl ether; POP·POE-butyl ether; tripolyoxypropylene glycerin ether; POP-glycerin ether; POP-glycerin ether phosphate; POP·POE-pentaneerythritol ether, etc.

[0028] Examples of ethers include those corresponding to the above alcohols, as well as ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol methyl ethyl ether, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diadipate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, and propylene glycol monophenyl ether acetate.

[0029] Examples of moisturizing agents include chondroitin sulfate and its salts, hyaluronic acid and its salts, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO)PO adduct, Rosa robur extract, yarrow extract, and melilot extract.

[0030] Surfactants include anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants.

[0031] Examples of anionic surfactants include fatty acid soaps (e.g., sodium laurate, sodium palmitate, etc.); higher alkyl sulfates (e.g., sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (e.g., POE triethanolamine lauryl sulfate, POE sodium lauryl sulfate, etc.); N-acyl sarcosinates (e.g., sodium lauroyl sarcosinate, etc.); higher fatty acid amide sulfonates (e.g., sodium N-myristoyl-N-methyl taurate, sodium coconut oil fatty acid methyl tauride, sodium lauryl methyl tauride, etc.); phosphate salts (sodium POE oleyl ether phosphate, sodium POE stearyl ether phosphate, etc.); sulfosuccinates (e.g., sodium di-2-ethylhexyl sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.); sodium carboxylate, etc.); alkylbenzenesulfonates (e.g., sodium linear dodecylbenzenesulfonate, triethanolamine linear dodecylbenzenesulfonate, linear dodecylbenzenesulfonic acid, etc.); higher fatty acid ester sulfate salts (e.g., sodium hydrogenated coconut oil fatty acid glycerin sulfate, etc.); N-acylglutamates (e.g., monosodium N-lauroylglutamate, disodium N-stearoylglutamate, monosodium N-myristoyl-L-glutamate, etc.); sulfated oils (e.g., turmeric oil, etc.); POE alkyl ether carboxylic acids; POE alkyl allyl ether carboxylate salts; α-olefin sulfonates; higher fatty acid ester sulfonates; secondary alcohol sulfate salts; higher fatty acid alkylolamide sulfate salts; sodium lauroylmonoethanolamide succinate; ditriethanolamine N-palmitoyl aspartate; sodium caseinate, etc.

[0032] Examples of cationic surfactants include alkyltrimethylammonium salts (e.g., stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (e.g., cetylpyridinium chloride, etc.); distearyldimethylammonium chloride dialkyldimethylammonium salts; poly(N,N'-dimethyl-3,5-methylenepiperidinium chloride); alkyl quaternary ammonium salts; alkyldimethylbenzylammonium salts; alkylisoquinolinium salts; dialkylmorphonium salts; POE alkylamines; alkylamine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride; benzethonium chloride, etc.

[0033] Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants (e.g., 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc.); betaine-based surfactants (e.g., 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkyl betaine, amido betaine, sulfobetaine, etc.).

[0034] Nonionic surfactants include sucrose fatty acid esters, alkyl glycosides, polyether-modified silicones (e.g., polyethylene glycol-10 dimethicone, polyethylene glycol-12 dimethicone, PEG-9 polymethylsiloxyethyl dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, etc.); polyglycerin-modified silicones (e.g., polyglyceryl-3 disiloxane dimethicone, polyglyceryl-3 polydimethylsiloxyethyl dimethicone, etc.); sorbitan fatty acid esters (e.g., sorbitan monooleate, sorbitan monostearate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmite, etc.); sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate, etc.); glycerin fatty acids (e.g., glycerin monocottonseed oil fatty acid, glycerin monoerucate, glycerin sesquioleate, glycerin monostearate, glycerin α,α'-oleic acid pyroglutamate, glycerin monostearate malate, etc.); propylene glycol fatty acid esters (e.g., propylene glycol monostearate, etc.); POE castor oil / hydrogenated castor oil derivatives (POE castor oil, POE hydrogenated castor oil, etc.); and non-hydrophilic nonionic surfactants such as glycerin alkyl ethers. Also included are polyglycerol fatty acid esters other than component (B) (e.g., polyglyceryl monooleate, polyglyceryl monostearate, etc.); POE sorbitan fatty acid esters (e.g., POE sorbitan monooleate, POE sorbitan monostearate, POE sorbitan tetraoleate, etc.); POE sorbit fatty acid esters (e.g., POE sorbit monolaurate, POE sorbit monooleate, POE sorbit pentaoleate, POE sorbit monostearate, etc.); POE glycerin fatty acid esters (e.g., POE monooleates such as POE glycerin monostearate, POE glycerin monoisostearate, POE glycerin triisostearate, etc.);POE fatty acid esters (e.g., POE distearate, POE monodioleate, ethylene glycol distearate, etc.); POE alkyl ethers (e.g., POE lauryl ether, POE oleyl ether, POE stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE cholestanol ether, etc.); POE alkyl phenyl ethers (e.g., POE nonylphenyl ether, etc.); Pluronic types (e.g., Pluronic (registered trademark), etc.); POE·POP alkyl ethers (e.g., POE·POP cetyl ether, POE·POP-2-decyltetradecyl ether, POE·POP monobutyl ether, POE·POP hydrogenated lanolin, POE·POP glycerin ether, etc.); tetra Hydrophilic nonionic surfactants such as POE-tetra-POP ethylenediamine condensates (e.g., Tetronic, etc.); POE castor oil hydrogenated castor oil derivatives (e.g., POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil triisostearate, POE hydrogenated castor oil monopyroglutamic acid monoisostearate diester, POE hydrogenated castor oil maleic acid, etc.); POE beeswax and lanolin derivatives (e.g., POE sorbitan beeswax, etc.); alkanolamides (e.g., coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE propylene glycol fatty acid esters; POE alkylamines; POE fatty acid amides; alkyl glucosides; alkyl ethoxydimethylamine oxides; and trioleyl phosphate.

[0035] Examples of sequestering agents include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, edetate disodium, edetate trisodium, edetate tetrasodium, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, and ethylenediaminehydroxyethyltriacetate trisodium salt.

[0036] Examples of pearlescent agents include glycol distearate and titanium mica.

[0037] Examples of amino acids include neutral amino acids (e.g., threonine, cysteine, etc.); basic amino acids (e.g., hydroxylysine, etc.); and the like. Examples of such an acid include sodium acyl sarcosine (sodium lauroyl sarcosine), acyl glutamate, sodium acyl β-alanine, glutathione, and pyrrolidone carboxylic acid.

[0038] Examples of organic amines include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-methyl-1-propanol.

[0039] Examples of polymer emulsions include acrylic resin emulsion, polyethyl acrylate emulsion, acrylic resin liquid, polyacrylic alkyl ester emulsion, polyvinyl acetate resin emulsion, and natural rubber latex.

[0040] Examples of pH adjusters include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate, and are usually used to adjust the pH of the internal phase (aqueous component).

[0041] Examples of vitamins include vitamins A, B1, B2, B6, C, E and their derivatives, pantothenic acid and its derivatives, biotin, etc.

[0042] Examples of antioxidants include tocopherols, dibutylhydroxytoluene (BHT), butylhydroxyanisole, pyrosulfite, gallic acid ester, phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, cephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetate.

[0043] Examples of preservatives include parabens and phenoxyethanol.

[0044] Examples of water-soluble polymers include natural water-soluble polymers such as plant-derived polymers (e.g., gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), algae colloid (cassow extract), starch (rice, corn, potato, wheat), glycyrrhizic acid); microbial-derived polymers (e.g., xanthan gum, dextran, succinoglucan, pullulan, etc.); and animal-derived polymers (e.g., collagen, casein, albumin, gelatin, etc.). semi-synthetic water-soluble polymers such as starch-based polymers (e.g., carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose-based polymers (hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, methylcellulose, ethylcellulose, hydroxypropylmethylcellulose stearoxy ether, sodium cellulose sulfate, carboxymethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, etc.); alginic acid-based polymers (e.g., sodium alginate, propylene glycol alginate, etc.), etc. Examples include synthetic water-soluble polymers such as polyoxyethylene polymers (for example, polyethylene glycol 20,000, 40,000, 60,000, etc.); polyethyleneimine; and cationic polymers.

[0045] Examples of various active ingredients include anti-inflammatory agents (e.g., salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.); whitening agents (e.g., placenta extract, saxifrage extract, arbutin, resorcinol derivatives, etc.); various extracts (e.g., Phellodendron bark, Coptis chinensis, Lithospermum root, Peony, Swertia japonica, Birch, sage, Loquat, Carrot, Aloe, Mallow, Iris, Grape, Job's tears, Loofah, Lily, Saffron, Cnidium rhizome, Angelica acutiloba, Garlic, Capsicum annuum, Angelica acutiloba, Seaweed, etc.), activators (e.g., Royal jelly, Photosensitizer, Cholesterol, sterol derivatives, etc.); blood circulation promoters (e.g., nonylic acid valenylamide, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, zingerone, cantharides tincture, ichthammol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, etc.); antiseborrheic agents (e.g., sulfur, thianthol, etc.); anti-inflammatory agents (e.g., tranexamic acid, thiotaurine, hypotaurine, etc.), etc.

[0046] The composition of the present invention can be produced according to a conventional method in accordance with the dosage form. [Example]

[0047] The present invention will be specifically described below with reference to examples, but these are merely examples of the present invention and the scope of the present invention is not limited to these examples.

[0048] An oil-in-water emulsion type composition was prepared according to the formulation shown in Table 1 by a conventional method. Aqueous compositions were prepared according to the formulations shown in Table 2 by conventional methods. A water-in-oil emulsion type composition was prepared according to the formulation shown in Table 3 by a conventional method.

[0049] Each of the resulting compositions was evaluated for the following items, and the results are shown in Table 1.

[0050] (crystallization) Each composition was placed in a glass standard bottle and left to stand in a thermostatic chamber set at 0°C for one month, after which a specialist evaluator visually evaluated the composition on the following four-point scale. ◎: No crystalline precipitation is observed ○: Very little crystalline precipitation is observed △: A small amount of crystalline matter is observed ×: Crystalline deposits observed

[0051] (sticky feeling) An appropriate amount of the cosmetic was applied to the skin, and the stickiness of the skin one minute after application was scored by a specialist evaluator according to the following criteria. 5 points: No stickiness 4 points: Almost no stickiness 3 points: Feels slightly sticky 2 points: Sticky feeling 1 point: Very sticky The average scores of the 10 evaluators were assigned to the following evaluations. ◎: Over 4 points: Very good ○: Over 3 points and 4 points or less: Good △: More than 2 points and 3 points or less: Slightly poor × : 2 points or less : Defective

[0052] (creaking sensation) An appropriate amount of the cosmetic was applied to the skin, and the feeling of roughness felt on the skin during application was scored by a specialist evaluator according to the following criteria. 5 points: No creaking sensation 4 points: Almost no creaking sensation 3 points: Slight creaking sensation 2 points: Feels creaky 1 point: Very creaky The average scores of the 10 evaluators were assigned to the following evaluations. ◎: Over 4 points: Very good ○: Over 3 points and 4 points or less: Good △: More than 2 points and 3 points or less: Slightly poor × : 2 points or less : Defective

[0053] (Moisturizing / Freshness) An appropriate amount of the cosmetic product was applied to the skin, and one minute after application, expert evaluators scored the skin's moisturizing / freshness according to the following criteria. 5 points: Very moist / feels fresh 4 points: Moist / refreshing feeling 3 points: Slightly moist / feels fresh 2 points: Almost no moist feeling 1 point: Not moist / refreshing The average scores of the 10 evaluators were assigned to the following evaluations. ◎: Over 4 points: Very good ○: Over 3 points and 4 points or less: Good △: More than 2 points and 3 points or less: Slightly poor × : 2 points or less : Defective

[0054] [Table 1-1]

[0055] [Table 1-2]

[0056] [Table 2-1]

[0057] [Table 2-2]

[0058] [Table 3-1]

[0059] [Table 3-2]

[0060] The compositions of the examples containing components (A) and (B) were found to be less sticky, and also had excellent feel when used, such as a lack of squeaky feeling and a moist / fresh feeling. Furthermore, the precipitation of crystals was suppressed, resulting in excellent formulation stability. [Industrial Applicability]

[0061] The composition of the present invention can be preferably applied to external skin preparations such as cosmetics, cosmetics including quasi-drugs, and medicines.

Claims

1. A composition comprising (A) dipotassium glycyrrhizinate and (B) polyglyceryl-10 (eicosanedioate / tetradecanedioate), The content of (A) is 0.2 to 1.0 mass% based on the total mass of the composition.

2. The composition according to claim 1, wherein the content of (B) is 0.0001 to 5% by mass based on the total mass of the composition.

3. The composition according to claim 1, wherein the mass ratio of the contents of component (A) and component (B) is 1:10 to 100:

1.

4. The composition according to any one of claims 1 to 3, which is an external preparation for skin.

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