Topical preparation for skin

Abstract

To provide a topical preparation for skin exhibiting superior usability even when containing active ingredients including niacinamide, dipotassium glycyrrhizate, or heparinoid, as well as an oily component and a surfactant.SOLUTION: A topical preparation for skin characterized by comprising (A) niacinamide, (B) dipotassium glycyrrhizate, (C) a heparinoid, (D) an oily component, (E) a surfactant, and (F) a divalent alcohol.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an external skin preparation containing niacinamide, dipotassium glycyrrhizinate, a heparinoid, an oily component, a surfactant, and a dihydric alcohol. [Background technology]

[0002] Various active ingredients can be incorporated into topical skin preparations. For example, niacinamide is known to be highly safe and to have anti-aging effects on the skin (Patent Document 1). However, niacinamide has issues such as stickiness after application to the skin and poor usability. It has also been proposed to incorporate dipotassium glycyrrhizinate or heparinoids into topical skin preparations in the hope of improving their skin benefits, but these ingredients are also known to have issues with usability. Furthermore, topical skin preparations often contain oily ingredients as a base, and it has also been proposed to incorporate surfactants or alcohols to dissolve the oily ingredients. However, these topical skin preparations have issues with usability, such as stickiness after application and poor moisturizing. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Publication No. 10-130135 Summary of the Invention [Problem to be solved by the invention]

[0004] Therefore, the present inventors have conducted various studies with the objective of providing an external skin preparation that contains active ingredients such as niacinamide, dipotassium glycyrrhizinate, and heparinoids, as well as an oily component and a surfactant, yet has an excellent feel when used. [Means for solving the problem]

[0005] As a result, the inventors have succeeded in developing an external skin preparation that is excellent in feel when used, by making it contain niacinamide, dipotassium glycyrrhizinate, a heparinoid, an oily component, a surfactant, and a dihydric alcohol, and have completed the present invention.

[0006] That is, the present invention is as follows. <1> A topical skin preparation characterized by containing (A) niacinamide, (B) dipotassium glycyrrhizinate, (C) a heparinoid, (D) an oily component, (E) a surfactant, and (F) a dihydric alcohol. <2> (D) The oil component is one or more selected from liquid, solid, and paste oil components. <1> The topical skin preparation according to claim 1. <3> (F) The dihydric alcohol is two or more selected from 1,3-butylene glycol, 1,2-pentanediol, and propylene glycol. <1> The topical skin preparation according to claim 1. <4> (E) The surfactant is at least one selected from nonionic surfactants and amphoteric surfactants. <1> The topical skin preparation according to claim 1. <5> (D) The oily component is at least one selected from the group consisting of fragrances, phytosterols, N-lauroyl-L-glutamic acid di(phytosteryl behenyl 2-octyldodecyl), macadamia nut oil fatty acid phytosteryl, and petrolatum. <1> or <2> The topical skin preparation according to claim 1. <6> (E) The surfactant is at least one selected from the group consisting of hydrogenated soybean phospholipid, polyglyceryl monostearate, lipophilic glyceryl monostearate, polyethylene glycol monostearate, polyoxyethylene polyoxypropylene decyl tetradecyl ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene cetyl ether, and polyoxyethylene stearyl ether. <1> or <4> The topical skin preparation according to claim 1. <7> The content of (C) is 0.05% by mass or more. <1> The topical skin preparation according to claim 1. <8> A topical skin preparation comprising (A) niacinamide at 3% by mass or more, (B) dipotassium glycyrrhizinate at 0.001% by mass or more, and (C) a heparinoid at 0.001% by mass or more. [Effects of the Invention]

[0007] According to the present invention, an external skin preparation having an excellent feel when used can be provided by containing niacinamide, dipotassium glycyrrhizinate, a heparinoid, an oily component, a surfactant, and a dihydric alcohol. DETAILED DESCRIPTION OF THE INVENTION

[0008] The topical skin preparation of the present invention will be described in detail below. The present invention is not limited to the following embodiments, and may be modified, added, modified, or deleted within the scope of what a person skilled in the art can conceive. Any embodiment is within the scope of the present invention as long as it exhibits the functions and effects of the present invention.

[0009] <(A) Niacinamide> The topical skin preparation of the present invention is characterized by containing niacinamide. Niacinamide is an amide of niacin (nicotinic acid / vitamin B3), a water-soluble vitamin that is a member of the B vitamin group. In the present invention, niacinamide that is commonly used in cosmetics and quasi-drugs can be used, and commercially available niacinamides such as those extracted from natural products, purified from natural products, and synthesized by known methods can also be used.

[0010] In the topical skin preparation of the present invention, niacinamide is preferably incorporated in the topical skin preparation at 3% by mass or more, more preferably 5% by mass or more, from the viewpoint of exerting its effect.The upper limit is not particularly limited, but is preferably 30% by mass or less, more preferably 20% by mass or less, and from the viewpoint of obtaining a topical skin preparation that is excellent in usability and enjoys the effect of niacinamide, it is particularly preferably 10% by mass or less.The content of niacinamide in the topical skin preparation of the present invention can be analyzed, for example, by high performance liquid chromatography.

[0011] <(B) Dipotassium glycyrrhizinate> The topical skin preparation of the present invention is characterized by containing dipotassium glycyrrhizinate. Dipotassium glycyrrhizinate is a salt of glycyrrhizic acid and potassium, and is also known as dipotassium glycyrrhizinate, dipotassium glycyrrhizinate, glycyrrhizinate K2, or glycinone K2. It is a component known to be contained in licorice (licorice) and has anti-inflammatory properties. In the present invention, dipotassium glycyrrhizinate typically used in cosmetics, quasi-drugs, etc. can be used. For example, commercially available products such as those extracted from natural products, purified from natural products, or synthesized by known methods can also be used.

[0012] The content of dipotassium glycyrrhizinate in the topical skin preparation of the present invention is not particularly limited, and is, for example, preferably 0.001% by mass or more, more preferably 0.01% by mass or more, and from the viewpoint of obtaining a topical skin preparation with excellent usability, particularly preferably 0.03% by mass or more. Also, it is preferably 10% by mass or less, more preferably 5% by mass or less, and particularly preferably 1% by mass or less. The content of dipotassium glycyrrhizinate in the topical skin preparation of the present invention can be analyzed, for example, by high performance liquid chromatography.

[0013] <(C) Heparinoids> The topical skin preparation of the present invention is characterized by containing a heparinoid. Heparinoids are polysulfated mucopolysaccharides such as chondroitin polysulfate, which are obtained by polysulfating a polysaccharide having a repeating unit of a disaccharide composed of D-glucuronic acid and N-acetyl-D-galactosamine. They are known to have moisturizing, anti-inflammatory, and blood circulation-promoting effects. In the present invention, heparinoids commonly used in cosmetics and quasi-drugs can be used, and commercially available products such as those extracted from natural products, purified from natural products, or synthesized by known methods can also be used.

[0014] The content of heparinoids in the topical skin preparation of the present invention is not particularly limited, and is, for example, preferably 0.001% by mass or more, more preferably 0.01% by mass or more, and from the viewpoint of obtaining a topical skin preparation with excellent usability, particularly preferably 0.05% by mass or more. It is also preferably 10% by mass or less, more preferably 5% by mass or less, and particularly preferably 1% by mass or less. The content of heparinoids in the topical skin preparation of the present invention can be analyzed, for example, by high-performance liquid chromatography or the organic sulfate group measurement method described in the Japanese Pharmacopoeia Non-Drug Ingredients Standards 2002, Quantitative Method for Heparinoids (3).

[0015] <(D) Oily component> The topical skin preparation of the present invention is characterized by containing an oily component. The oily component is not particularly limited as long as it is one normally used in topical skin preparations, but an oily component that is liquid, solid, or paste-like at 25°C is preferred. Specific examples of the oily component include essential oils extracted from the flowers, leaves, peels, seeds, roots, resin, and wood of natural plants (e.g., citrus fruits such as orange oil, grapefruit oil, bergamot oil, lemon oil, and yuzu oil, lavender oil, ylang-ylang oil, geranium oil, peppermint oil, lemongrass oil, Lilium longiflorum fruit oil, spearmint oil, tea tree leaf oil, basil oil, pelargonium graveolens oil, bitter orange flower oil, Cinnamon leaf oil, cardamom seed oil, salvia oil, juniper oil, wild rose oil, Roman chamomile flower oil, and rosemary leaf oil), and chemically synthesized fragrances (fragrance oils). Oils, for example, fragrances (fragrances) such as hydrocarbons, alcohols, aldehydes, ketones, esters, lactones, phenols, acetals, etc. (compounds with aromatic chemical structures); phytosterols, which are plant sterols and plant stanols; waxes such as candelilla wax, carnauba wax, beeswax, jojoba seed oil, and lanolin; fatty acids such as isostearic acid, oleic acid, and polyhydroxystearic acid; fats and oils such as macadamia seed oil, olive fruit oil, argania spinosa kernel oil, castor oil, and shea butter; higher alcohols such as cetyl alcohol, stearyl alcohol, octyldodecanol, and tetradecyldecanol;Isopropyl palmitate, isopropyl myristate, isopropyl stearate, isobutyl stearate, 2-ethylhexyl stearate, isopropyl isostearate, butyl isostearate, decyl isostearate, lauryl isostearate, isodecyl isodecanoate, isodecyl isononanoate, isotridecyl isononanoate, isononyl isononanoate, diisostearyl malate, neopentyl glycol dioctanoate, propylene glycol dicaprate, propylene glycol dicaprylate, glyceryl tri-2-ethylhexanoate, polyglyceryl monoisostearate, polyglyceryl diisostearate, diglyceryl triisostearate, diglyceryl tetraisostearate, diethyl sebacate, 2-ethylhexyl hydroxybenzoate Examples of the oils include ester oils such as cetyl xanthate, ethylhexyl palmitate, octyldodecyl myristate, oleyl oleate, ethyl oleate, macadamia nut fatty acid phytosteryl, N-lauroyl-glutamic acid di(phytosteryl / 2-octyldodecyl), N-lauroyl-glutamic acid di(phytosteryl / behenyl / 2-octyldodecyl), N-lauroyl-glutamic acid di(cholesteryl / 2-octyldodecyl), and N-lauroyl-sarcosine-isopropyl; silicone oils such as dimethylpolysiloxane, cyclopentasiloxane, and alkoxy-modified polysiloxane; and hydrocarbons such as squalane, mineral oil, petrolatum, and microcrystalline wax. One or more of these oils may be used. In the present invention, fragrances, phytosterols, macadamiate phytostearyl, N-lauroyl-glutamic acid di(phytosteryl / behenyl / 2-octyldodecyl), and petrolatum are preferred, and fragrances that are liquid at 25°C (specifically, synthetic fragrances, orange peel oil, lavender oil, pelargonium graveolens oil, bergamot fruit oil, bergamot peel oil, grapefruit peel oil, lemon peel oil, yuzu peel oil, ylang-ylang flower oil, wild rose oil, Roman chamomile flower oil, and rosemary leaf oil), phytosterols that are solid at 25°C, and macadamiate phytostearyl, N-lauroyl-glutamic acid di(phytosteryl / behenyl / 2-octyldodecyl), and petrolatum are more preferred.

[0016] The content of the oily component in the external preparation for skin of the present invention is not particularly limited, and is, for example, preferably 0.00001% by mass or more, more preferably 0.0001% by mass or more, and from the viewpoint of obtaining an external preparation for skin with excellent usability, particularly preferably 0.001% by mass or more. Also, it is preferably 50% by mass or less, more preferably 40% by mass or less, and particularly preferably 30% by mass or less. When two or more oily components are blended, the total amount is the total amount.

[0017] <(E) Surfactant> The topical skin preparation of the present invention is characterized by containing a surfactant. The surfactant is not particularly limited as long as it is one that is normally used in topical skin preparations, but for example, preferred surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, polymeric surfactants, etc. The HLB of the surfactant is not particularly limited, and surfactants from a low HLB of about 1 to a high HLB of about 20 can be used, and it is also preferable to combine surfactants with low and high HLBs. Preferable examples of surfactants include anionic surfactants, such as fatty acid salts such as potassium laurate, alkyl sulfate ester salts, polyoxyethylene alkyl sulfate salts, acyl N-methylamino acid salts, acylamino acid salts, polyoxyethylene alkyl ether acetate salts, succinate ester salts, fatty acid alkanolamide ether carboxylate salts, polyoxyethylene fatty amine sulfate salts, fatty acid alkanolamide sulfate salts, fatty acid glyceride sulfate salts, alkylbenzene polyoxyethylene sulfate salts, olefin sulfonates, alkyl sulfosuccinates, alkyl ether sulfosuccinates, alkylbenzene sulfonates, alkyl naphthalene sulfonates, alkanesulfonates, α-sulfofatty acid methyl ester salts, acyl isethionates, alkyl glycerides, and the like. Examples of the nonionic surfactants include alkyl ether sulfonates, alkyl sulfoacetates, alkyl ether phosphate ester salts, alkyl phosphate ester salts, sodium caseinate, alkylaryl ether phosphates, fatty acid amide ether phosphates, phospholipids, and silicone-based anionic surfactants. Examples of nonionic surfactants include polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, and derivatives thereof; sorbitan fatty acid esters such as sorbitan monopalmitate, sorbitan monostearate, sorbitan monooleate, sorbitan tristearate, and sorbitan trioleate; glycerin fatty acid esters such as glyceryl monostearate, self-emulsifying glyceryl monostearate, lipophilic glyceryl monostearate, and glyceryl monoisostearate;Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene glyceryl monostearate, polyoxyethylene glyceryl monoisostearate, polyoxyethylene glyceryl tristearate, polyoxyethylene glyceryl triisostearate, and polyoxyethylene glyceryl trioleate; polyoxyethylene alkyl ethers such as polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene oleyl ether, and polyoxyethylene octyldodecyl ether; polyethylene glycol fatty acid esters such as polyethylene glycol monolaurate and polyethylene glycol monooleate; polyglyceryl monolaurate, monomyristyl Polyglycerin fatty acid esters such as polyglyceryl phosphate, polyglyceryl monostearate, polyglyceryl monooleate, polyglyceryl tristearate, and polyglyceryl trioleate; polyethylene glycol fatty acid esters such as polyethylene glycol monooleate, polyethylene glycol monostearate, and polyethylene glycol monolaurate; polyalkylene glycol fatty acid esters such as propylene glycol monostearate, propylene glycol monolaurate, and propylene glycol monooleate; polyoxyethylene polyoxypropylene alkyl ethers such as polyoxyethylene polyoxypropylene decyltetradecyl ether and polyoxyethylene polyoxypropylene cetyl ether;Examples of cationic surfactants include alkyltrimethylammonium chloride, alkyltrimethylammonium bromide, dialkyldimethylammonium chloride, fatty acid amidoamines and their salts, alkyletheramines and their salts or quaternary salts, fatty acid amide quaternary ammonium salts, polyoxyethylene alkylamines and their salts or quaternary salts, alkylamine salts, fatty acid amide guanidium salts, alkyletheramine ammonium salts, alkyltrialkyleneglycol ammonium salts, benzalkonium salts, benzethonium salts, pyridinium salts, imidazolinium salts, alkylisoquinolinium salts, dialkyl Examples of amphoteric surfactants include morpholinium salts, polyamine fatty acid derivatives, amino-modified silicones, and silicone-based cationic surfactants. Examples of amphoteric surfactants include sphingophospholipids such as lecithin, phosphatidylcholine, and sphingomyelin, phosphatidic acid, cyclic lysophosphatidic acid or its salts, and lysolecithin; phospholipid derivatives such as hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, and partially hydrogenated egg yolk phospholipid; N-alkyl-N,N-dimethyl amino acid betaines; fatty acid amidoalkyl-N,N-dimethyl amino acid betaines; imidazoline betaines; alkyl sulfobetaines; sulfate betaines; and phosphate betaines. Examples of polymeric surfactants include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymers; alkylated sugar polymers such as hydrophobized hydroxypropyl methylcellulose and hydroxyethyl cellulose hydroxypropyl stearyl ether / sodium hydroxypropyl sulfonate; and various silicone-based surfactants. These may be used alone or in combination of two or more.

[0018] The content of surfactant in the topical skin preparation of the present invention is not particularly limited, and is, for example, preferably 0.001% by mass or more, more preferably 0.01% by mass or more, and from the viewpoint of obtaining a topical skin preparation with excellent usability, particularly preferably 0.1% by mass or more. Also, it is preferably 20% by mass or less, more preferably 10% by mass or less, and particularly preferably 5% by mass or less. When two or more surfactants are blended, the content is the total amount thereof.

[0019] <(F) Dihydric alcohol> The topical skin preparation of the present invention is characterized by containing a dihydric alcohol. A dihydric alcohol refers to an alcohol with a valence of 2. The dihydric alcohol used in the present invention is not particularly limited as long as it is one typically used in topical skin preparations. For example, a dihydric alcohol having 2 to 20 carbon atoms is preferred, a dihydric alcohol having 2 to 16 carbon atoms is more preferred, and a dihydric alcohol having 2 to 10 carbon atoms is particularly preferred. Specific examples of such dihydric alcohols include ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, 1,3-propanediol, 1,3-butylene glycol, 1,2-butylene glycol, dibutylene glycol, tributylene glycol, polybutylene glycol, 1,2-pentanediol (pentylene glycol), 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, neopentyl glycol, and 1,2-hexadecanediol. In the present invention, propylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, dibutylene glycol, tributylene glycol, polybutylene glycol, 1,2-pentanediol (pentylene glycol), 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, neopentyl glycol, and 1,2-hexadecanediol are preferred, and 1,3-butylene glycol, 1,2-pentanediol, and propylene glycol are particularly preferred.

[0020] The total content of two or more dihydric alcohols in the topical skin preparation of the present invention is not particularly limited, and is, for example, preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and from the viewpoint of obtaining a topical skin preparation with excellent usability, particularly preferably 1% by mass or more. Also, it is preferably 50% by mass or less, more preferably 40% by mass or less, and particularly preferably 35% by mass or less.

[0021] <Other ingredients> In addition to the above-mentioned components, the topical skin preparation of the present invention may contain other components as needed. These other components may include one or more of the components typically used in topical skin preparations, such as active ingredients such as thickeners, gelling agents, moisturizers, dispersants, plasticizers, spreading agents, preservatives, film-forming agents, pH adjusters, deodorants, chelating agents, antioxidants, antibacterial agents, antibacterial and antifungal agents, anti-inflammatory agents, and whitening agents, as well as cosmetic and medicinal ingredients such as animal extracts, plant extracts, and vitamins other than niacinamide.

[0022] <External skin preparations> The topical skin preparation of the present invention is a composition to be applied to the skin. When the topical skin preparation of the present invention is an oil-in-water type, the viscosity of the topical skin preparation of the present invention is preferably 500 mPa·s or more, more preferably 1,000 mPa·s or more, and from the viewpoint of excellent usability, particularly preferably 3,000 mPa·s or more. The viscosity of the topical skin preparation of the present invention can be measured, for example, with a B-type viscometer (Brookfield rotational viscometer, temperature: 25°C, rotation speed: 5 rpm).

[0023] The pH of the topical skin preparation of the present invention is preferably 3 to 9, and from the viewpoint of excellent usability, more preferably 4 to 8.5. The pH of the topical skin preparation of the present invention can be measured, for example, by the glass electrode method using a pH meter.

[0024] The topical skin preparation of the present invention can be used in pharmaceuticals, quasi-drugs, and cosmetics, and can be used in skin care cosmetics such as lotions, emulsions, creams, serums, gels, etc. Among these, the topical skin preparation of the present invention is preferably a lotion, emulsion, serum, or cream, more preferably a lotion, serum, or cream, and particularly preferably an oil-in-water type serum or cream.

[0025] The topical skin preparation of the present invention can be produced by a conventional method. For example, when obtaining an oil-in-water composition, (A) niacinamide, (B) dipotassium glycyrrhizinate, (C) heparinoid, and optionally a moisturizer, a thickener, etc. are uniformly dispersed in water to prepare an aqueous phase, and then a pre-homogenized oil component, a surfactant, an alcohol, etc. are added, and the mixture is uniformly emulsified using a homomixer or the like, and the pH is adjusted as necessary to obtain the topical skin preparation of the present invention. [Example]

[0026] The present invention will be described below based on examples, but the present invention is not limited to these examples and can take various forms. The amount of each component used in the examples is in mass % unless otherwise specified.

[0027] <Preparation of topical skin preparation> The topical skin preparations of Examples 1 to 8 were prepared according to Table 1 by the following method. Specifically, (A), (B), and (C) were heated in water to uniformly dissolve them to prepare an aqueous phase, and then fragrance (liquid), phytosterols (solid), N-lauroyl-L-glutamic acid di(phytosteryl behenyl 2-octyldodecyl) (paste), macadamia nut oil fatty acid phytosteryl (paste), and petrolatum (paste) were added as (D), and hydrogenated soybean phospholipid, polyglyceryl monostearate, lipophilic glyceryl monostearate, and monostearate were added as (E). Polyethylene glycol tearate, polyoxyethylene polyoxypropylene decyl tetradecyl ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene cetyl ether, or polyoxyethylene stearyl ether, along with 1,3-butylene glycol, 1,2-pentanediol, or propylene glycol (F), were heated in advance to prepare a homogenized oil phase, which was then added to the aqueous phase and uniformly solubilized or emulsified using a homomixer, followed by cooling.

[0028] [Table 1]

[0029] <Evaluation of topical skin preparations> (1) Evaluation of usability The resulting topical skin preparation was evaluated for its feel upon use. Samples were used at the time of manufacture (day 0). Five subjects in their 20s and 30s were randomly selected as test subjects. The topical skin preparation was applied to the test subjects' faces, and the test subjects were asked to comprehensively evaluate the feel upon use (stickiness after application, moisturizing sensation, and fragrance) as evaluation items, and then complete a questionnaire based on a five-point rating scale. The average value for each item in the questionnaire was calculated and evaluated. The results are shown in Table 2. (No stickiness after application) 5: Very good (non-sticky and feels great to use) 4: Good (not too sticky, feels good to use) 3: Neither 2: Bad (slightly sticky and uncomfortable to use) 1: Very bad (sticky, unusable) (Moisturizing feeling after application) 5: Very good (very moisturizing after application) 4: Good (moisturized after application) 3: Neither (feels slightly moist after application) 2: Poor (hardly any moist feeling after application) 1: Very bad (no moist feeling after application, not suitable for use) (Fragrance) 5: Very good (very good fragrance) 4: Good (somewhat strong aroma) 3: Neither (normal fragrance) 2: Bad (fragrance is not very strong) 1: Very bad (poor aroma)

[0030] (2) Evaluation of moisturizing properties The moisturizing properties of the obtained topical skin preparations were evaluated. Two subjects in their 20s and 30s were randomly selected as subjects. 0.03 ml of the skin cosmetic preparations of the examples and comparative examples of the present invention was applied to a 3 x 3 cm area on the inside of the subject's forearm. After acclimatization for 15 minutes in an environment of 26.8°C temperature and 37.5% relative humidity, the moisture content of the stratum corneum (conductance value) was measured using a Corneometer (MPA580, Courage+Khazaka). The percentage change was calculated when the moisture content before application was set to 100%, and the average value for the two subjects was then calculated. The results are shown in Table 2.

[0031] [Table 2]

[0032] All of the topical skin preparations of the present invention had an excellent feel when used. The topical skin preparations of Examples 1 to 8 were not sticky after application and left the skin feeling moisturized after application, compared to the topical skin preparations of Comparative Examples 1 to 8, and had an excellent feel when used, and also increased the moisture content of the stratum corneum. Furthermore, the topical skin preparations of Examples 1 to 4, which contained a fragrance as an oily component, all had a more pleasant fragrance than the topical skin preparations of Comparative Examples 1 to 4.

[0033] From the above, it can be seen that the topical skin preparation of the present invention is a topical skin preparation that has an excellent feel when used, such as being non-sticky after application and providing a moist feeling after application.Furthermore, it can be seen that the topical skin preparation of the present invention not only has an excellent feel when used, but also has an excellent fragrance and moisturizing properties.

[0034] <Preparation of topical skin preparation> The lotions listed in Tables 3 and 4 were prepared in the same manner as in the Examples. The obtained lotions all had a pH of 5 to 8, were non-sticky after use, left a moist feeling, and had a pleasant fragrance, providing an excellent feeling when used.

[0035] [Table 3]

[0036] [Table 4]

[0037] The oil-in-water serums listed in Table 5 were prepared in the same manner as in the Examples. The obtained serums had a viscosity of 3,000 mPa·s or more, a pH of 5 to 8, were non-sticky after use, and were moisturizing, had a pleasant fragrance, and were excellent in feel.

[0038] [Table 5]

[0039] The oil-in-water cream-type topical skin preparations listed in Table 6 were prepared in the same manner as in Example 1. The obtained topical skin preparations had a viscosity of 50,000 mPa·s or more, a pH of 5 to 8, were non-sticky after use, and were moisturizing, had a pleasant fragrance, and were excellent in feel.

[0040] [Table 6] [Industrial Applicability]

[0041] The topical skin preparation of the present invention contains niacinamide, dipotassium glycyrrhizinate, a heparinoid, an oily component, a surfactant, and a dihydric alcohol, and therefore can provide a topical skin preparation that is excellent in feel when used and has high potential for industrial applicability.

Claims

1. A topical skin preparation characterized by containing (A) niacinamide, (B) dipotassium glycyrrhizinate, (C) a heparinoid, (D) an oily component, (E) a surfactant, and (F) a dihydric alcohol.

2. 2. The external preparation for skin according to claim 1, wherein the oily component (D) is at least one selected from the group consisting of liquid, solid, and paste-like oily components.

3. 2. The external skin preparation according to claim 1, wherein the surfactant (E) is at least one selected from nonionic surfactants and amphoteric surfactants.

4. 2. The external skin preparation according to claim 1, wherein the dihydric alcohol (F) is two or more selected from 1,3-butylene glycol, 1,2-pentanediol, and propylene glycol.

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