Lipid membrane structure-containing composition, and cosmetic and topical skin preparation comprising the same

Abstract

To provide means enabling simple preparation of a lipid membrane structure-containing composition.SOLUTION: A lipid membrane structure-containing composition comprising (A) a lipid membrane structure-forming component, (B) a polyol compound, (C) water, and (D) a functional component.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a lipid membrane structure-containing composition, and to cosmetics and topical skin preparations containing the lipid membrane structure-containing composition. [Background technology]

[0002] Lipid membrane structures such as liposomes and bicelles have skin care effects such as moisturizing and improving skin quality, and can encapsulate active ingredients, making them useful in cosmetics and topical skin preparations. While phospholipids, glycolipids, lipoproteins, and the like are examples of raw materials for lipid membrane structures used in the above applications, phospholipids are primarily used because they are naturally derived and highly safe. Among these, hydrogenated phospholipids, in which hydrogen atoms are added to the unsaturated carbon bonds of phospholipids, are preferred because they are less susceptible to degradation by oxidation.

[0003] Furthermore, by incorporating functional ingredients into lipid membrane structures such as liposomes and bicelles, these lipid membrane structures can be incorporated into cosmetics and topical skin preparations, thereby making the skin care effects more effective.

[0004] To date, techniques for forming lipid membrane structures, particularly using hydrogenated phospholipids, have been investigated. For example, Patent Document 1 describes that liposomes with high lipid membrane flexibility and storage stability can be obtained by preparing a composition in which hydrogenated phospholipids are mixed with ceramides, branched alcohols, etc., and dispersing the mixture in a large excess of water. Patent Document 2 describes that multilayer liposomes can be formed by mixing an oil-soluble composition containing hydrogenated phospholipids, a glycol compound, and a fat-soluble compound with a water-soluble composition, and then treating the mixture in a conversion process to obtain fine unilamellar liposomes. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Laid-Open No. 2011-32230 [Patent Document 2] Special Publication No. 2012-504620 Summary of the Invention [Problem to be solved by the invention]

[0006] For use in cosmetics and topical skin preparations, fine lipid membrane structures (e.g., with an average particle size of 200 nm or less) are required from the viewpoints of skin penetration, the expression of the effects of the encapsulated active ingredients, and storage stability. However, hydrogenated phospholipids have a higher phase transition temperature than non-hydrogenated phospholipids, making it difficult to form fine lipid membrane structures. In fact, in the techniques for forming lipid membrane structures using hydrogenated phospholipids as described in Patent Documents 1 and 2, it was necessary to use a micronization means such as a microfluidizer in order to form fine lipid membrane structures (e.g., with an average particle size of 200 nm or less).

[0007] Therefore, an object of the present invention is to provide a means for easily forming a composition containing fine lipid membrane structures containing an active ingredient. [Means for solving the problem]

[0008] The present inventors have conducted extensive research to solve the above-mentioned problems, and as a result have found that the above-mentioned problems can be achieved by preparing a lipid membrane structure-containing composition containing a lipid membrane structure-forming component, a polyol compound, water, and a functional component, thereby completing the present invention. [Effects of the Invention]

[0009] According to the present invention, a composition containing fine lipid membrane structures can be easily formed. [Brief explanation of the drawings]

[0010] [Figure 1] 1 is a photograph of a lipid membrane structure formed in a lipid membrane structure-containing composition of an example, observed by cryo-electron microscopy (Cryo-TEM). DETAILED DESCRIPTION OF THE INVENTION

[0011] The lipid membrane structure-containing composition according to the present invention contains (A) a lipid membrane structure-forming component, (B) a polyol compound, (C) water, and (D) a functional component, and in particular, contains (A) a phospholipid and (B) a compound represented by the following formula 1:

[0012] [ka]

[0013] In the above formula 1, R is a substituted or unsubstituted alkyl group having 2 to 6 carbon atoms or a substituted or unsubstituted cycloalkyl group having 3 to 6 carbon atoms; X is -O-, -C(=O)O- or -OC(=O)-; n is 0 or 1.

[0014] (D) Functional ingredients are not particularly limited as long as they are expected to have various functional effects such as maintaining health, exhibiting antioxidant properties, or mitigating the effects of substances that inhibit human body functions, and examples thereof include oily bases, moisturizers, texture improvers, polymers, thickeners, gelling agents, antioxidants, reducing agents, oxidizing agents, antioxidants, whitening agents, vitamins and their derivatives, plant, animal, and microbial extracts, UV absorbers, antibacterial and preservatives, chelating agents, pH adjusters, acids and alkalis, solvents and propellants, antipruritics, exfoliants and dissolving agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, anti-inflammatory and anti-inflammatory agents, hair growth agents, blood circulation promoters, and stimulants, hormones, anti-wrinkle and anti-aging agents, irritation-reducing agents, cooling agents, warming agents, powders, dyes, colorants, dyes, and pigments, and fragrances.

[0015] The lipid membrane structure-containing composition of the present invention makes it possible to form fine lipid membrane structures (for example, with an average particle size of 200 nm or less) without the need for a micronizing means such as a microfluidizer.

[0016] As described above, lipid membrane structures such as liposomes and bicelles are useful in cosmetics and topical skin preparations. For these applications, fine lipid membrane structures (e.g., with an average particle diameter of 200 nm or less) are required from the viewpoints of skin permeability, the expression of the effects of the encapsulated active ingredients, and storage stability. Phospholipids are primarily used as raw materials for lipid membrane structures in these applications because they are naturally derived and highly safe. Among these, hydrogenated phospholipids are preferred because they are less susceptible to deterioration by oxidation. However, compared to non-hydrogenated phospholipids, hydrogenated phospholipids have a higher phase transition temperature, and the physical properties of the two are significantly different. For this reason, the techniques described in Patent Documents 1 and 2 make it difficult to easily form fine lipid membrane structures (e.g., with an average particle diameter of 200 nm or less) using hydrogenated phospholipids with high phase transition temperatures.

[0017] Therefore, the present inventors have intensively investigated means for easily forming a composition containing fine lipid membrane structures, and as a result, have surprisingly found that a composition containing (A) a lipid membrane structure-forming component, (B) a polyol compound, (C) water, and (D) a functional component can form a lipid membrane structure-containing composition having fine lipid membrane structures (e.g., an average particle size of 200 nm or less) without the need for a micronization means.

[0018] A preferred embodiment of the present invention will be described below, but the present invention is not limited to the following embodiment.

[0019] As used herein, "lipid membrane structures" refers to particles having a lamellar (lipid bilayer) structure in which lipid molecules are arranged with their hydrophilic groups facing outward and their hydrophobic groups facing each other. Specific forms include those described in the section below titled "Lipid Membrane Structure-Containing Composition." Furthermore, as used herein, lipid membrane structures are considered to be formed if the average particle size of a prepared lipid membrane structure-containing composition can be measured using a dynamic light scattering measurement device, more specifically, a Zetasizer Nano ZSP (manufactured by Malvern Instruments).

[0020] In this specification, the range "x to y" is inclusive of x and y and means "x or more and y or less." Unless otherwise specified, operations and measurements of physical properties are performed at room temperature (20 to 25°C) and a relative humidity of 40 to 50% RH.

[0021] <Composition containing lipid membrane structure> The present invention provides a lipid membrane structure-containing composition.

[0022] The lipid membrane structure-containing composition contains (A) a lipid membrane structure-forming component, (B) a polyol compound, (C) water, and (D) a functional component, particularly (A) a phospholipid and (B) a compound represented by the following formula 1:

[0023] [ka]

[0024] In the above formula 1, R is a substituted or unsubstituted alkyl group having 2 to 6 carbon atoms or a substituted or unsubstituted cycloalkyl group having 3 to 6 carbon atoms; X is -O-, -C(=O)O- or -OC(=O)-; n is 0 or 1.

[0025] [Component (A)] The lipid membrane structure-containing composition of the present invention includes, as component (A), any lipid membrane structure-forming component, particularly phospholipids and further hydrogenated phospholipids. Component (A) may be one or a combination of two or more lipid membrane structure-forming components.

[0026] Hydrogenated phospholipids can be obtained by adding hydrogen atoms to the unsaturated carbon bonds of phospholipids using conventionally known methods. The origin of the phospholipid is not particularly limited, but lecithin is particularly preferred because it is naturally derived and can be suitably used in cosmetics and topical skin preparations. Therefore, in one embodiment of the present invention, component (A) is hydrogenated lecithin. Lecithin may be derived from soybeans, egg yolk, rapeseed, sunflower, corn, etc., but is preferably derived from plants such as soybeans, rapeseed, sunflower, or corn, and is more preferably derived from soybeans due to its ease of availability and stable quality.

[0027] The component (A) may be either a synthetic product or a commercially available product. Examples of commercially available products include NIKKOL (registered trademark) Lecinol S-10 and S-10PLUS manufactured by Nikko Chemicals Co., Ltd., EMALEX (registered trademark) SLP manufactured by Nippon Emulsion Co., Ltd., and SLP-White H manufactured by Tsuji Oil Mills Co., Ltd. These may be used alone or in combination of two or more.

[0028] [(B) Component] The lipid membrane structure-containing composition of the present invention contains a polyol compound as component (B). In the present invention, the polyol compound is an aliphatic compound having two or more hydroxy groups, and is not limited to saturated or unsaturated compounds, regardless of whether it has other functional groups. It may also be a compound having a phenyl group. It is particularly desirable to contain a compound represented by the following formula 1. Component (B) may be one type or two or more types.

[0029] [ka]

[0030] In the above formula 1, R is a substituted or unsubstituted alkyl group having 2 to 6 carbon atoms or a substituted or unsubstituted cycloalkyl group having 3 to 6 carbon atoms.

[0031] The alkyl group having 2 to 6 carbon atoms may be either linear or branched. Examples of the alkyl group having 2 to 6 carbon atoms include ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isoamyl, tert-pentyl, neopentyl, sec-pentyl, 3-pentyl, n-hexyl, 3-methylpentan-2-yl, 3-methylpentan-3-yl, 4-methylpentyl, 4-methylpentan-2-yl, 1,3-dimethylbutyl, 3,3-dimethylbutyl, and 3,3-dimethylbutan-2-yl. The alkyl group having 2 to 6 carbon atoms is preferably linear. That is, the alkyl group having 2 to 6 carbon atoms is preferably a group selected from the group consisting of ethyl, n-propyl, n-butyl, n-pentyl, and n-hexyl.

[0032] Examples of the cycloalkyl group having 3 to 6 carbon atoms include a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, and a cyclohexyl group, and preferably a cyclohexyl group.

[0033] There are no particular limitations on the substituents that may be present on the alkyl group having 2 to 6 carbon atoms and the cycloalkyl group having 3 to 6 carbon atoms, as long as the effects of the present invention are achieved. Examples of the substituents include halogen atoms, hydroxy groups, acyl groups, alkyl groups, aryl groups, alkoxyl groups, nitro groups, amino groups, and cyano groups. However, the alkyl group having 2 to 6 carbon atoms is not substituted with an alkyl group.

[0034] In the above formula 1, X is -O-, -C(=O)O-, or -OC(=O)-, and is preferably -O-. Furthermore, in the above formula 1, n is 0 or 1. In the above formula 1, when X is -O- and n is 1, the number of carbon atoms in the alkyl group represented by R is preferably 4 or more.

[0035] The component (B) is preferably at least one selected from the group consisting of, for example, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, cyclohexylglycerin, and hexylglycerin.

[0036] In particular, when 1,2-hexanediol, 1,2-heptanediol, or cyclohexylglycerin is used as component (B), extremely fine lipid membrane structures can be formed. In this case, the lipid membrane structures are thought to form bicelles. Because bicelles are disc-shaped single-layer lamellar structures, they have superior permeability to the stratum corneum compared to liposomes of comparable particle size. Therefore, from the perspective of obtaining lipid membrane structures with high permeability for lipid-soluble components, it is preferable to use at least one selected from the group consisting of 1,2-hexanediol, 1,2-heptanediol, and cyclohexylglycerin as component (B).

[0037] Component (B) may be either a synthetic product or a commercially available product.

[0038] In the lipid membrane structure-containing composition of the present invention, the content of component (B) exceeds 100 parts by mass per 100 parts by mass of component (A). When the content of component (B) is 100 parts by mass or less per 100 parts by mass of component (A), fine lipid membrane structures cannot be formed. Furthermore, the content of component (B) is preferably 150 parts by mass or more per 100 parts by mass of component (A). When the content is 150 parts by mass or more, component (A) is more easily dispersed in component (C), making it possible to form lipid membrane structures with excellent dispersibility in the aqueous phase. Furthermore, from the viewpoint of obtaining finer lipid membrane structures, the content of component (B) is preferably 200 parts by mass or more, more preferably 250 parts by mass or more, even more preferably 300 parts by mass or more, even more preferably 350 parts by mass or more, and particularly preferably 400 parts by mass or more per 100 parts by mass of component (A). On the other hand, there is no particular upper limit to the content of component (B) per 100 parts by mass of component (A), but even if it exceeds 2000 parts by mass, it does not affect the dispersibility of component (A) in component (C) and is simply uneconomical. Therefore, the content of component (B) is preferably 2000 parts by mass or less per 100 parts by mass of component (A). Therefore, according to a preferred embodiment of the present invention, the content of component (B) is preferably 150 to 2000 parts by mass per 100 parts by mass of component (A).

[0039] [(C) component] The lipid membrane structure-containing composition of the present invention further contains water as component (C). Component (C) serves as a dispersion medium for lipid membrane structures containing components (A), (B), and the following component (D) (functional component), and also serves to facilitate the incorporation of water-soluble components of component (D) into the lipid membrane structure-containing composition. Specifically, component (D) can be easily incorporated into the lipid membrane structure-containing composition by dissolving the water-soluble components of component (D) in component (C) beforehand and then mixing with components (A) and (B).

[0040] Component (C) is preferably water with few impurities, such as purified water, which is purified from tap water using a system that employs ion exchange, distillation, reverse osmosis, or ultrafiltration, either alone or in combination.

[0041] [(D) component] (D) The functional ingredients may include, for example, one or more selected from oily bases, moisturizers, texture improvers, polymers, thickeners, gelling agents, antioxidants, reducing agents, oxidizing agents, antioxidants, whitening agents, vitamins and their derivatives, plant, animal, and microbial extracts, UV absorbers, antibacterial agents and preservatives, chelating agents, pH adjusters, acids and alkalis, solvents and propellants, antipruritics, exfoliants and dissolving agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, anti-inflammatory and anti-inflammatory agents, hair growth agents, blood circulation promoters, and stimulants, hormones, anti-wrinkle and anti-aging agents, irritation soothing agents, cooling agents, warming agents, powders, dyes, colorants, dyes, pigments, and fragrances.

[0042] Examples of oily bases include higher alcohols such as cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, selachyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, and isostearyl alcohol. Higher fatty acids such as carboxylic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, long-chain α-hydroxy fatty acids, dimer acids, hydrogenated dimer acids, and their aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts, sodium salts, and other metal soaps, as well as nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaben, Hydrocarbons such as paraffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, and solid paraffin; waxes such as candelilla wax, carnauba wax, rice wax, Japan wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, and ethylene-propylene copolymer; coconut oil, palm oil, and palm oil. Vegetable oils and fats such as coconut oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, and hydrogenated jojoba oil; animal oils and fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, and turtle oil;Animal waxes such as spermaceti, lanolin, and orange roughy oil; lanolin derivatives such as liquid lanolin, reduced lanolin, adsorbed and purified lanolin, acetated lanolin, acetated liquid lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acids, hard lanolin fatty acids, lanolin alcohol, acetated lanolin alcohol, and cetyl lanolyl acetate ester; phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, and sphingolipids such as sphingomyelin, phosphatidic acid, cyclic lysophosphatidic acid or its salt, and lysolecithin; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, and cholic acid; sapogenins; cholesteryl acetate, cholesteryl nonanoate, and cholesteryl stearate. sterol esters such as cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / octyldodecyl), N-lauroylsarcosinate isopropyl, acyl sarcosine alkyl esters such as cholesteryl 12-hydroxystearate, cholesteryl macadamiate, phytosteryl macadamiate, phytosteryl sunflower seed oil fatty acid, phytosteryl isostearate, cholesteryl soft lanolinate, cholesteryl hard lanolinate, cholesteryl long-chain branched fatty acid, and cholesteryl long-chain α-hydroxy fatty acid;Octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolinate, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hydrogenated castor oil isostearate, Monoalcohol carboxylic acid esters such as ethyl oleate, avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolinate, methylheptyl laurate, methylheptyl myristate, methylheptyl palmitate, methylheptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, and triethyl citrate; oxyacid esters such as cetyl lactate, hydrogenated castor oil monoisostearate, γ-erucalactone, and diisostearyl malate;Glyceryl Trioctanoate, Glyceryl Trioleate, Glyceryl Triisostearate, Glyceryl Diisostearate, Caprylic / Capric Triglyceride, Caprylic / Capric / Myristic / Stearic Triglyceride, Hydrogenated Rosin Triglyceride (Hydrogenated Ester Gum), Rosin Triglyceride (Ester Gum), Glyceryl Behenate Eicosandioate, Trimethylolpropane Trioctanoate, Trimethylolpropane Triisostearate, Neopentyl Glycol Dioctanoate, Dicaprylate Neopentyl glycol dioctanoate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, pentaerythrityl hydrogenated rosin, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane isostearate / sebacic acid, pentaerythrityl triethylhexanoate, dipentaerythrityl hydroxystearate / stearic acid / rosin acid, diglyceryl diisostearate, polyglyceryl tetraisostearate Polyol fatty acid esters such as ethylene glycol distearate, 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethyl-1,5-pentanediol dineopentanoate, polyglyceryl-10 nonaisostearate, polyglyceryl-8 deca(erucate / isostearate / ricinoleate), diglyceryl oligoester of hexyldecanoate / sebacic acid, glycol distearate, alkyl ethers such as dicaprylyl ether, diisopropyl dimer dilinoleate, dimer Derivatives of dimer acid or dimer diol such as diisostearyl dimer dilinoleate, di(isostearyl / phytosteryl) dimer dilinoleate, phytosteryl / behenyl dimer dilinoleate, phytosteryl / isostearyl / cetyl / stearyl / behenyl dimer dilinoleate, dimer dilinoleyl dimer dilinoleate, dimer dilinoleyl diisostearate, dimer dilinoleyl hydrogenated rosin condensate, hydrogenated castor oil dimer dilinoleate, and hydroxyalkyl dimer dilinoleyl ether;Fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), and coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyl trimethicone, diphenyl dimethicone, phenyl dimethicone, (aminoethyl aminopropyl methicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, and silicone resin. Examples of silicones include silicone rubber, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicones, sugar-modified silicones, carboxylic acid-modified silicones, phosphate-modified silicones, sulfate-modified silicones, alkyl-modified silicones, fatty acid-modified silicones, alkyl ether-modified silicones, amino acid-modified silicones, peptide-modified silicones, fluorine-modified silicones, cation-modified and polyether-modified silicones, amino-modified and polyether-modified silicones, alkyl-modified and polyether-modified silicones, amidoalkyl-modified silicones, aminoglycol-modified silicones, aminophenyl-modified silicones, and polysiloxane-oxyalkylene copolymers; and fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyethers.

[0043] Moisturizing agents and feel improvers include polyols and their polymers such as glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, and ethylene glycol-propylene glycol copolymer; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether; water-soluble esters such as polyglyceryl-10 (eicosane diacid / tetradecanedioic acid), polyglyceryl-10 tetradecanedioate, and bisethoxydiglycol cyclohexanedicarboxylate; and sugar alkyl esters such as sorbitol, xylitol, erythritol, mannitol, and maltitol. Alcohols; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylated and hydroxyalkylated), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycol Sugars and their derivatives, such as cogen, ethyl glucoside, and glucosyl ethyl methacrylate polymers or copolymers; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronin sulfate, keratosulfate, dermatan sulfate; Tremella fuciformis extract, Tremella fuciformis polysaccharide; fructans, such as inulin and levan; fucoidan; tuberose polysaccharide, naturally occurring polysaccharides; organic acids, such as citric acid, tartaric acid, and lactic acid, and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its sodium salts, etc.Amino acids and their salts, such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, and creatine; collagen, fish-derived collagen, atelocollagen, and ze Protein peptides and their derivatives such as keratin, elastin, collagen hydrolysis peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin hydrolysis peptides, keratin hydrolysis peptides, hydrolyzed keratin, conchiolin hydrolysis peptides, hydrolyzed conchiolin, silk proteolytic peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soybean proteolytic peptides, wheat proteolytic peptides, hydrolyzed wheat protein, casein hydrolysis peptides, acylated peptides; palmitoyl oligopeptides, palmitoyl peptides Acylated peptides such as pentapeptide and palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture medium, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; animal and plant extracts such as placenta extract, alastin, collagen, aloe extract, witch hazel water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, rose rouge extract, yarrow extract, eucalyptus extract, and melilot extract; Examples of ceramides include ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide EOP, ceramide NG, ceramide NP, ceramide EOS, ceramide NS, ceramide AS, ceramide AG, ceramide AP, dihydroxylignoceroylphytosphingosine, sphingolipids, hydroxyceramides, pseudoceramides, glycosphingolipids (e.g., cerebrosides, horse sphingolipids, corn sphingolipids, rice bran sphingolipids, glucosylceramides, etc.), ceramide- and glycoceramide-containing extracts, etc.;

[0044] Polymers, thickeners, and gelling agents include guar gum, locust bean gum, queen seed, carrageenan, galactan, gum arabic, tara gum, tamarind, furcellaran, karaya gum, aoi, caragam, tragacanth gum, pectin, pectinic acid and its sodium salts, alginic acid and its sodium salts, mannan; starches from rice, corn, potato, wheat, etc.; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin, chitin, etc. Tosan, agar, cassou extract, chondroitin sulfate, casein, collagen, gelatin, albumin; cellulose and its derivatives such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and its sodium salts, methylhydroxypropyl cellulose, dialkyldimethylammonium cellulose sulfate, crystalline cellulose, cellulose powder, etc.; starch-based polymers such as soluble starch, carboxymethyl starch, methylhydroxypropyl starch, methyl starch, etc.; arsenic chloride Starch derivatives such as hydroxypropyltrimonium starch and corn starch aluminum octenylsuccinate; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), vinylpyrrolidone-vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylate copolymers such as (methacryloyloxyethyl carboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine oxide methacrylate) copolymer; (dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymer; acrylic resins with alkanolamine; polyesters, water-dispersible polyesters; polyacrylamides;Polyacrylic acid ester copolymers such as polyethyl acrylate, carboxyvinyl polymers, polyacrylic acid and its salts such as sodium salt, acrylic acid-methacrylic acid ester copolymers; acrylic acid-alkyl methacrylate copolymers; cationized cellulose such as Polyquaternium-10, diallyldimethylammonium chloride-acrylamide copolymers such as Polyquaternium-7, acrylic acid-diallyldimethylammonium chloride copolymers such as Polyquaternium-22, acrylic acid-diallyldimethylammonium chloride-acrylamide copolymers such as Polyquaternium-39, acrylic acid-cationized methacrylic acid ester copolymers, acrylic acid-cationized methacrylic acid amide copolymers, acrylic acid-methyl acrylate-methacrylamidopropyltrimethylammonium chloride copolymers such as Polyquaternium-47, methacrylic acid choline ester chloride polymers; cationized oligosaccharides, cationized dextran, cations such as guar hydroxypropyltrimonium chloride, etc. Examples of suitable polymers include ionized polysaccharides, polyethyleneimine, cationic polymers, 2-methacryloyloxyethyl phosphorylcholine polymers such as polyquaternium-51 and copolymers with butyl methacrylate copolymers, acrylic resin emulsions, polyethyl acrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, natural rubber latex, and synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone copolymers such as acrylic-silicone graft copolymers; various fluorine-containing polymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, fumed silica (ultrafine silicic anhydride particles), aluminum magnesium silicate, sodium magnesium silicate, metal soaps, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, and fructooligosaccharide fatty acid esters.

[0045] Examples of antioxidants include tocopherol (vitamin E), tocopherol derivatives such as tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine ​​hydrochloride.

[0046] Examples of reducing agents include thioglycolic acid, cysteine, and cysteamine.

[0047] Oxidizing agents include hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate. Examples include:

[0048] Antioxidants include ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid; ascorbic acid glucoside and its fatty acid esters such as ascorbic acid-2-glucoside; Examples of suitable antioxidants include ascorbic acid derivatives such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate; vitamin A compounds such as retinol, retinol acetate, retinol palmitate, and hydrogenated retinol; vitamin E compounds such as tocopherol, tocopherol acetate, and tocotrienol; carotenoids such as carotene, lycopene, astaxanthin, and lutein; polyphenols such as phlorotannin, curcumin, anthocyanin, proanthocyanin, catechin, ellagic acid, quercetin, and apple polyphenols; coenzyme Q10, lipoic acid, lactoferrin, sesamin, hesperidin, protoanthocyanidin, lignan, chlorogenic acid, rutin, fullerene, and platinum nanocolloid.

[0049] Examples of whitening agents include hydroquinone glycosides and esters thereof, such as arbutin and α-arbutin; ascorbic acid, ascorbic acid phosphate salts, such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters, such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid derivatives, such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid; ascorbic acid ethers; ascorbic acid glucoside and its fatty acid esters such as ascorbic acid-2-glucoside; ascorbic acid derivatives such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate; tranexamic acid derivatives such as tranexamic acid, cetyl tranexamate, and tranexamic acid amide; licorice extract-related substances such as glabridin, glabrene, liquiritin, and isoliquiritin; and plant extracts such as kojic acid, ellagic acid, ferulic acid and their derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomilla extract, oil-soluble licorice extract, Nishikawa willow extract, and saxifrage extract.

[0050] Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, and retinol palmitate; vitamin B such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide and benzyl nicotinate, and choline; vitamin C such as ascorbic acid and its sodium salts; vitamin D; vitamin E such as α-, β-, γ-, and δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt. ascorbic acid phosphate salts such as ascorbic acid tetraisopalmitate, ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate, and other ascorbic acid fatty acid esters; ascorbic acid alkyl ethers such as ascorbic acid ethyl ether; ascorbic acid glucoside and its fatty acid esters such as ascorbic acid-2-glucoside; ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, tocopherol phosphate, and other tocopherol derivatives; tocotrienols, and various other vitamin derivatives.

[0051] Plant, animal and microbial extracts include iris extract, angelica extract, dolabrata extract, asparagus extract, avocado extract, hydrangea extract, almond extract, althaea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, chinko extract, fennel extract, turmeric extract, oolong tea extract, uva-ursi extract, angelica tree extract, echinacea leaf extract, emmeiso extract, scutellaria root extract, phellodendron bark extract, coptis japonica extract, barley extract, ginseng extract, St. John's wort extract, and nettle root. Sow extract, Ononis extract, Dutch mustard extract, orange extract, dried seawater, seaweed extract, oyster leaf extract, oak extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, Pueraria root extract, chamomilla extract, oil-soluble chamomilla extract, carrot extract, artemisia capillaris extract, oat extract, kalk extract, licorice extract, oil-soluble licorice extract, kiwi extract, ash extract, wood ear extract, cinchona extract, cucumber extract, paulownia leaf extract, guanosine, guava extract, lily of the valley extract, gardenia extract, kumazasa extract, Sophora flavescens extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar extract, chlorella extract, mulberry extract, gentian extract, geranium extract, black tea extract, yeast extract, magnolia bark extract, coffee extract, burdock extract, rice extract, fermented rice extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, cowberry extract, Chinese radish extract, Bupleurum Root extract, umbilical cord extract, saffron extract, salvia extract, soapwort extract, bamboo grass extract, hawthorn extract, Chinese holly Kisu, Zanthoxylum extract, Shiitake mushroom extract, Rehmannia root extract, Lithospermum root extract, Perilla extract, Tilia extract, Meadowsweet extract, Jatoba extract, Peony extract, Angelica root extract, Calamus root extract, Birch extract, White wood ear extract, Horsetail extract, Stevia extract, Stevia fermented product, Nishikawa willow extract, Ivy extract, Hawthorn extract, Elderberry extract, Yarrow extract, Peppermint extract, Sage extract, Mallow extract, Cnidium extract, Swertia japonica extract, Sophora japonica extract, Rhubarb extract,Soybean extract, Chinese laurel extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, Imperata cylindrica extract, tangerine extract, tea tree oil, sweet tea extract, chili pepper extract, angelica extract, calendula extract, peach kernel extract, spruce extract, Houttuynia cordata extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, burdock extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, parietaria extract, jasmine extract, bisabolol, cypress extract, bifidobacteria extract, loquat extract, coltsfoot extract, butterbur shoot extract, poria cocos extract, butcher's broom extract, grape extract, Examples of such extracts include dough seed extract, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, squid extract, pine extract, horse chestnut extract, skunk cabbage extract, soapberry extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, coix seed extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, lychee extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and burnet extract.

[0052] Examples of ultraviolet absorbers include benzoic acid-based ultraviolet absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerin ester, N,N-dipropoxypara-aminobenzoic acid ethyl ester, N,N-diethoxypara-aminobenzoic acid ethyl ester, N,N-dimethylpara-aminobenzoic acid ethyl ester, N,N-dimethylpara-aminobenzoic acid butyl ester, and N,N-dimethylpara-aminobenzoic acid ethyl ester; anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid and its sodium salt, amyl salicylate, and menthyl salicylate. salicylic acid-based ultraviolet absorbers such as phenyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanol phenyl salicylate; octyl cinnamate, ethyl 4-isopropyl cinnamate, methyl 2,5-diisopropyl cinnamate, ethyl 2,4-diisopropyl cinnamate, methyl 2,4-diisopropyl cinnamate, propyl p-methoxycinnamate, isopropyl p-methoxycinnamate, isoamyl p-methoxycinnamate, 2-ethylhexyl Cinnamic acid-based UV absorbers such as ethyl p-methoxycinnamate (octyl para-methoxycinnamate), 2-ethoxyethyl p-methoxycinnamate (cinoxate), cyclohexyl p-methoxycinnamate, ethyl α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocurine), glyceryl mono-2-ethylhexanoyl-di-para-methoxycinnamate, ferulic acid and its derivatives; 2,4-dihydroxybenzophenone, 2,2-dihydroxy-4-methoxybenzophenone, 2,2-dihydroxybenzophenone, benzophenone-based ultraviolet absorbers such as 4,4-dimethoxybenzophenone, 2,2,4,4-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, and 4-hydroxy-3-carboxybenzophenone;3-(4-Methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2-hydroxy-5-methylphenylbenzotriazole; 2-(2-hydroxy-5-t-octylphenyl)benzotriazole; 2-(2-hydroxy-5-methylphenylbenzotriazole; Dibenzalazine; Dianisoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; Dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; Octyltriazole urocanic acid and urocanic acid derivatives such as ethyl urocanate; hydantoin derivatives such as 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, and 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate, phenylbenzimidazol sulfonic acid, terephthalylidene dicamphor sulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives;

[0053] Antibacterial and antiseptic agents include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-alkanediols such as 1,2-decanediol; alkyl glyceryl ethers such as 2-ethylhexylglyceryl ether (ethylhexylglycerin); salicylic acid; lanolin fatty acids and their salts; benzoic acid and its salts; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; and phenols. halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, and phenylphenol sodium; phenylethyl alcohol, photosensitive materials, antibacterial zeolites, and silver ions.

[0054] Examples of chelating agents include edetates (ethylenediaminetetraacetates) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetates such as HEDTA3Na; pentetates (diethylenetriaminepentaacetate); phytic acid; phosphonic acids such as etidronic acid and salts thereof such as their sodium salts; sodium oxalate; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, and tartaric acid.

[0055] Examples of pH adjusters, acids, and alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

[0056] Solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyl diol; diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, and propylene glycol monoethyl ether. Examples of suitable propellants include glycol ethers such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, and propylene glycol monoethyl ether acetate; glycol ether esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbons, next-generation chlorofluorocarbons; LPG, dimethyl ether, and carbon dioxide gas.

[0057] Antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance P inhibitors, and the like.

[0058] Examples of keratin exfoliating and dissolving agents include salicylic acid, sulfur, resorcinol, selenium sulfide, pyridoxine, glycolic acid, and the like.

[0059] Examples of antiperspirants include aluminum chlorohydrate, aluminum chloride, zinc oxide, and zinc paraphenolsulfonate.

[0060] Examples of the cooling agent include menthol and methyl salicylate. Astringents include citric acid, tartaric acid, lactic acid, aluminum and potassium sulfate, tannic acid, and caffeine.

[0061] Examples of the enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, and protease. Examples of nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and adenosine triphosphate disodium.

[0062] Examples of anti-inflammatory agents include glycyrrhizinic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid and its derivatives, azelaic acid and its derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and mugwort leaf extract.

[0063] Hair growth agents, blood circulation promoters, and stimulants include plant extracts and tinctures such as Swertia japonica extract, capsicum tincture, ginger tincture, ginger extract, and cantharis tincture; capsaicin, nonylic acid valenylamide, zingerone, ichthammol, tannic acid, borneol, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, gamma-oryzanol, cepharanthine, vitamin E, and derivatives such as tocopherol nicotinate and tocopherol acetate, gamma-oryzanol, nicotinic acid, and derivatives such as nicotinamide, nicotinic acid benzyl ester, inositol hexanicotinate, and nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmastanol and their glycosides, and minoxidil.

[0064] Examples of hormones include estradiol, estrone, ethinylestradiol, cortisone, hydrocortisone, and prednisone.

[0065] Examples of anti-wrinkle and anti-aging agents include ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid; ascorbic acid glucosides and their fatty acid esters such as ascorbic acid 2-glucoside; ascorbic acid sulfate, tocopheryl ascorbyl phosphate, and other ascorbic acid esters. Examples of suitable vitamins include: retinol, retinol acetate, retinol palmitate, hydrogenated retinol, and other vitamin A derivatives; nicotinamide, glutathione, cysteine, crocetin, sericin, geraniol, glycerin glucoside, lactoferrin, proanthocyanin, pantothenic acid, panthenol, revelastol, isoflavones, coenzyme Q10, chondroitin sulfate, acetylglucosamine, glycerophosphatidylcholine, hydrolyzed hyaluronic acid, collagen peptides, conchiolin hydrolysate, adenosine 5'-monophosphate, phosphatidylinositol, trifluoroisopropyloxopropylaminocarbonylpyrrolidinecarbonylmethylpropylaminocarbonylbenzoylaminoacetate sodium, tranexamic acid, and derivatives thereof.

[0066] Examples of irritation-reducing agents include mannosylerythritol lipid, dimer dilinoleic acid diethylene glycol oligomer ester, diisostearyl malate, N-acyl-L-glutamic acid, trehalose monofatty acid ester, fatty acid amidoamine oxide, alkyldimethylamine oxide, phenylethyl glucoside, lauryl glucoside, ferulic acid glucoside, salicin, cedrol, polyethylene glycol, and polypropylene glycol.

[0067] Examples of cooling agents include menthol, camphor, menthyl lactate, monomenthyl succinate, menthyl acetate, borneol, cineol, thymol, peppermint oil, and derivatives thereof.

[0068] Examples of warming agents include vanillin and its derivatives, nonanoic acid vanillylamide, shogaol, gingerol, capsicum tincture, capsicum extract, nicotinic acid derivatives such as benzyl nicotinate, methyl nicotinate, phenyl nicotinate, and tocopherol nicotinate, capsaicin, watercress extract, Japanese pepper extract, ginger extract, and canthari extract.

[0069] Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, lepidolite, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salts, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soap (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, Prussian blue, carbon black, titanium oxide Examples of suitable inorganic powders include inorganic powders such as titanium dioxide, fine and ultrafine particles, zinc oxide, fine and ultrafine particles, zinc oxide, alumina, silica, fumed silica (ultrafine particle anhydrous silicic acid), titanium mica, fish scale foil, boron nitride, photochromic pigments, synthetic fluorine-containing phlogopite, fine particle composite powder, gold, and aluminum; and organic powders and organic-inorganic composite powders such as starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate-polymethyl methacrylate laminate powder, polyethylene terephthalate-aluminum-epoxy laminate powder, urethane powder, silicone powder, and Teflon (registered trademark) powder.

[0070] Examples of inorganic salts include sodium chloride-containing salts such as table salt, regular salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, and ammonium chloride; sodium sulfate, aluminum sulfate, aluminum-potassium sulfate (alum), aluminum-ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, and copper sulfate; and sodium phosphates such as monosodium, disodium, and trisodium phosphate, potassium phosphates, calcium phosphates, and magnesium phosphates.

[0071] Colorants, colorants, dyes, and pigments include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404, Green No. 3, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402, Red No. 102, Red No. 104-1, Red No. 105-1, Red No. 106, Red No. 2, Red No. 3, Red 201, Red 202, Red 203, Red 204, Red 205, Red Color 206, Red 207, Red 208, Red 213, Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230-1, Red 23 No. 0-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 404, Red No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange 2 Legal dyes such as No. 06, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1, Yellow No. 202-2, Yellow No. 203, Yellow No. 204, Yellow No. 205, Yellow No. 4, Yellow No. 401, Yellow 402, Yellow No. 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow No. 407, and Yellow No. 5; other acid dyes such as Acid Red 14; basic dyes; nitro dyes; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red iron oxide) and iron titanate; inorganic brown pigments such as gamma-iron oxide Color pigments; inorganic yellow pigments such as yellow iron oxide and ochre; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and Prussian blue; pearl pigments such as titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, colored titanium oxide-coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold;Examples include natural pigments and dyes such as anthraquinones (e.g., astaxanthin, alizarin), anthocyanidins, β-carotene, catenal, capsanthin, chalcone, carthamine, quercetin, crocin, chlorophyll, curcumin, naphthoquinones (e.g., cochineal, shikonin), bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, and rutin; oxidation dye intermediates and couplers (e.g., p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine, and salts thereof; autoxidation dyes (e.g., indoline); and dihydroxyacetone.

[0072] Fragrance: acetyl cedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, isoe super, isobutylquinoline, iris oil, iron, indole, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, estragole, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galacsolids, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethylbenzylcarbinyl acetate, styraryl acetate, cedryl acetate, terpineol acetate, pt-butylcyclohexyl acetate Al, vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamen aldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, gamma-terpinene, tripluran, nerol, nonanal, 2,6-Nonadienol, Nonalactone, Patchouli Alcohol, Vanilla Absolute, Vanillin, Basil Oil, Patchouli Oil, Hydroxycitronellal, Alpha-Pinene, Piperitone, Phenethyl Alcohol, Phenylacetaldehyde, Petitgrain Oil, Hexyl Cinnamaldehyde, Cis-3-Hexenol, Balsam of Peru, Vetiver Oil, Vetiverol, Peppermint Oil, Pepper Oil, Heliotropin, Bergamot Oil, Benzyl Benzoate Examples of fragrances include synthetic and natural fragrances such as zoate, borneol, myrresinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, lyral, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, and various essential oils, as well as various blended fragrances.

[0073] In addition to the functional ingredients described above, other functional ingredients include antihistamines, humectants, oily ingredients, ultraviolet blocking agents, fat-soluble substances, and additives.

[0074] Examples of antihistamines include antibiotics such as tetracycline hydrochloride, diphenhydramine hydrochloride, chlorpheniramine, diphenylimidazole and chloramphenicol, diphenhydramine, chlorpheniramine maleate, diphenhydramine hydrochloride, chlorpheniramine and diphenylimidazole.

[0075] Humectants include glycerin, propylene glycol, sorbitol, 1,3-butylene glycol, dl-pyrrolidonecarboxylic acid, and sodium lactate.

[0076] Oily ingredients include almond oil, olive oil, hardened oil, camellia oil, castor oil, Japan wax oil, coconut oil, beeswax, spermaceti, lanolin, carnauba wax, candelilla wax, liquid paraffin, petrolatum, microcrystalline wax, ceresin, squalene, lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, octyldodecanol, cholesterol, hexyldecanol, white sterol, cetyl lactate, Examples include isopropyl myristate, hexyl laurate, myristyl myristate, isopropyl palmitate, octyldodecanol myristate, butyl stearate, cocoa oil, Japan wax, jojoba oil, grapeseed oil, avocado oil, mink oil, egg yolk oil, beeswax, spermaceti, lanolin, carnauba wax, candelilla wax, liquid paraffin, ceresin wax, paraffin wax, behenic acid, isopropyl adipate, octyldodecyl myristate, octyldodecyl oleate, and cholesterol oleate.

[0077] Examples of ultraviolet blocking agents include benzophenone-based agents such as ASL-24, Cyasorb UV-9, and Uvinul M-40, benzoic acid-based agents such as Salol, azole-based agents such as Tinuvin P, nitrile-based agents such as Uvinul N-35, urea-based agents such as Ancour UA, para-amino acid-based agents such as Neo Heliopan Give tan F, 2-hydroxy-4-methoxybenzophenone, octyl dimethyl para-aminobenzoate, and ethylhexyl para-methoxycyanamate, salicylic acid-based agents, benzofuran-based agents, coumarin-based agents, and azole-based agents.

[0078] Lipid-soluble substances include ascorbic acid isopalmitate, ascorbic acid-2-phosphate-6-palmitate, ascorbic acid-2-phosphate-6-isopalmitate, ascorbic acid tetrahexyldecanoate, ascorbic acid-6-palmitate, ascorbic acid-2,6-dipalmitate, ascorbic acid-6-stearate, retinol, retinoic acid, retinol palmitate, tocopheryl retinoate, retinoic acid palmitate, retinoic acid isopalmitate, retinoic acid stearate, retinol stearate, astaxanthin, lutein, lycopene, beta-carotene, alpha-carotene, alpha-tocopherol, beta-tocopherol, gamma-tocopherol, dimethylglycine tocopherol, ubiquinone, and coenzyme A. , Tocotrienol, Mineral Oil, Liquid Paraffin, Squalane, Isopropyl Palmitate, Isopropyl Myristate, Isooctyl Myristate, Isotridecyl Myristate, Octadecyl Myristate, Octyldodecyl Myristate, Isostearyl Cholesteryl Ester, 2-Ethylhexanoic Acid Triglyceride, 2- Cetyl ethylhexanoate, sunflower oil, olive oil, jojoba oil, camellia oil, grapeseed oil, avocado oil, macadamia nut oil, almond oil, rice germ oil, clove oil, orange oil, spruce oil, pycnogenol, coenzyme A, iris extract oil, angelica extract oil, hibiscus extract oil, asparagus extract oil, avocado extract oil, amacha extract oil, almond extract oil, althea extract oil, arnica extract oil, aloe extract oil, apricot extract oil, apricot kernel extract oil, ginkgo extract oil, inchiko extract oil, Fennel extract oil, turmeric extract oil, oolong tea extract oil, uva-ursi extract oil, star anise extract oil, echinacea leaf extract oil, Enmeiso extract oil, Scutellaria root extract oil, Phellodendron bark extract oil, Coptis japonica extract oil, barley extract oil, Panax ginseng extract oil, St. John's wort extract oil, dead nettle extract oil, Ononis extract oil, watercress extract oil, orange extract oil, dried seawater, seaweed extract oil, persimmon leaf extract oil, kakyō extract oil, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk,Pueraria lobata extract oil, chamomilla extract oil, carrot extract oil, mugwort extract oil, oat extract oil, karkade extract oil, licorice extract oil, oil-soluble licorice extract oil, kiwi extract oil, angelica extract oil, wood ear extract oil, cinchona extract oil, cucumber extract oil, paulownia leaf extract oil, guanosine, guava extract oil, liquorice root extract oil, gardenia extract oil, bamboo grass extract oil, sophora angustifolia extract oil, walnut extract oil, chestnut extract oil, grapefruit extract oil, clematis extract oil, black rice extract oil, Fat-soluble brown sugar extract, fat-soluble black vinegar extract, chlorella extract oil, mulberry extract oil, gentian extract oil, geranium extract oil, black tea extract oil, yeast extract oil, magnolia bark extract oil, coffee extract oil, burdock extract oil, rice extract oil, fermented rice extract oil, fermented rice bran extract oil, rice germ oil, comfrey extract oil, collagen, cowberry extract oil, Chinese radish extract oil, Bupleurum extract oil, umbilical cord extract, saffron extract oil, salvia extract oil, soapwort extract oil, bamboo extract oil, hawthorn extract oil, Sanshi Extract oil of shiitake mushroom, extract oil of rehmannia root, extract oil of lithospermum root, extract oil of perilla, extract oil of linden tree, extract oil of meadowsweet, extract oil of jatoba, extract oil of peony, extract oil of angelica tree, extract oil of calamus root, extract oil of white birch, extract oil of white fungus, extract oil of horsetail, extract oil of stevia, fermented stevia, extract oil of willow, extract oil of ivy, extract oil of hawthorn, extract oil of elderberry, extract oil of yarrow, extract oil of peppermint, Mallow extract oil, Cnidium extract oil, Swertia japonica extract oil, Sophora japonica extract oil, Rhubarb extract oil, Soybean extract oil, Chinese laurel extract oil, Thyme extract oil, Dandelion extract oil, Lichen extract oil, Tea extract oil, Clove extract oil, Imperata cylindrica extract oil, Citrus tangerine extract oil, Tea tree oil, Sweet tea extract oil, Chili pepper extract oil, Angelica acutiloba extract oil, Calendula extract oil, Peach kernel extract oil, Spruce extract oil, Houttuynia cordata extract oil, Tomato extract oil, Natto extract oil, Carrot extract oil,Garlic extract oil, wild rose extract oil, hibiscus extract oil, burdock extract oil, lotus extract oil, parsley extract oil, birch extract oil, honey, witch hazel extract oil, parietaria extract oil, holly extract oil, bisabolol, cypress extract oil, bifidobacteria extract oil, loquat extract oil, coltsfoot extract oil, butterbur extract oil, poria extract oil, butcher's broom extract oil, grape extract oil, grape seed extract oil, propolis, loofah extract oil, safflower extract oil, peppermint extract oil, linden extract oil, peony extract oil, hop extract oil, squid extract oil, pine extract oil, horse chestnut extract oil, skunk cabbage extract oil, soapberry extract oil, melissa extract oil, mozuku extract oil, peach extract oil, cornflower extract oil, eucalyptus extract oil, saxifrage extract oil, yuzu extract oil, lily extract oil, coix seed extract oil, mugwort extract oil, lavender extract oil, green tea extract oil, eggshell membrane extract oil, apple extract oil, rooibos tea extract oil, lychee extract oil, lettuce extract oil, lemon extract oil, forsythia extract oil, astragalus extract oil, rose extract oil, rosemary extract oil, Roman chamomile extract oil, royal jelly extract oil, burnet extract oil, dimethyl silicone oils such as octamethyltrisiloxane, decamethyltetrasiloxane, methylpolysiloxane, and highly polymerized methylpolysiloxane; Examples of suitable silicone oils include cyclic silicone oils such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, methylcyclopolysiloxane, and methylpolycyclosiloxane; and methylphenylsilicone oils such as polyether-modified silicone oils and methylphenylpolysiloxane.

[0079] Additives include hydrocarbons such as hydrocarbons, waxes, fatty acids, higher alcohols, ester oils, silicone oils, fluorine-based oils, ozokerite, squalane, squalene, ceresin, paraffin, paraffin wax, liquid paraffin, pristane, polyisobutylene, microcrystalline wax, and petrolatum; waxes such as beeswax, carnauba wax, candelilla wax, and whale wax; animal oils such as beef tallow, beef leg fat, beef bone fat, hardened beef tallow, hardened oil, turtle oil, lard, horse fat, mink oil, liver oil, and egg yolk oil; lanolin, liquid lanolin, reduced lanolin, and lanolin alcohol; Hard lanolin, lanolin acetate, lanolin fatty acid isopropyl, phosphatidylcholine, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, oleic acid, linoleic acid, arachidonic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), isostearic acid, 12-hydroxystearic acid and other fatty acids, lauryl alcohol, myristyl alcohol, palmityl alcohol, stearyl alcohol, behenyl alcohol, hexadecyl alcohol, oleyl alcohol, isostearyl alcohol , hexyldodecanol, octyldodecanol, cetostearyl alcohol-2-decyltetradecinol, cholesterol, phytosterol, sitosterol, lanosterol, higher alcohols such as monostearyl glycerin ether (batyl alcohol), diisobutyl adipate, 2-hexyldecyl adipate, di-2-heptylundecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene glycol di-2-ethylhexanoate Cetyl 2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, cetyl octanoate, octyldodecyl gum ester, oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl glycol dicaprate, triethyl citrate, 2-ethylhexyl succinate, amyl acetate, ethyl acetate, butyl acetate, isocetyl stearate, butyl stearate, diisopropyl sebacate, di-2-ethylhexyl sebacate, cetyl lactate, myristyl lactate,Ester oils such as isopropyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, 2-heptylundecyl palmitate, cholesteryl 12-hydroxystearate, dipentaerythritol fatty acid esters, isopropyl myristate, octyldodecyl myristate, 2-hexyldecyl myristate, myristyl myristate, hexyldecyl dimethyloctanoate, ethyl laurate, hexyl laurate, N-lauroyl-L-glutamic acid 2-octyldodecyl ester, and diisostearyl malate, acetoglyceride, triisooctanoic acid glyceride, triisostearic acid glyceride, triisopalmitic acid glyceride, and tri-2-ethylhexanoic acid Examples of suitable oils include glycerides, monostearate glyceride, di-2-heptylundecanoate glyceride, and trimyristic acid glyceride; higher alkoxy-modified silicones such as dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, tetramethyltetrahydrogencyclotetrasiloxane, and stearoxysilicone; higher fatty acid-modified silicones; silicone resins; silicone rubbers; and silicone resins; and fluorine-based oils such as perfluoropolyether, perfluorodecalin, and perfluorooctane.

[0080] <Lipid membrane structures and lipid membrane structure compositions> The form of the lipid membrane structure is not particularly limited as long as it has a lamellar (lipid bilayer) structure in which lipid molecules are arranged with their hydrophilic groups facing outward and their hydrophobic groups facing inward, and examples thereof include liposomes, bicelles, and α-gels. The lipid membrane structure may be a single-layer lamellar structure called a unilamellar or single-lamellar structure, a multi-layered (2 to 10) lamellar structure called an oligolamellar structure, a multi-layered structure with more layers, or a mixture of these. The lipid membrane structure is preferably a single-layer lamellar structure. A single-layer lamellar structure has a fine particle size and is excellent in compound encapsulation efficiency and skin permeability. The fact that the lipid membrane structure is a single-layer lamellar structure can be confirmed, for example, using cryo-electron microscopy (cryo-TEM). In one embodiment of the present invention, the lipid membrane structure is preferably a single-layer lamellar liposome. A single-layer lamellar liposome has a fine particle size and a large internal aqueous phase volume, resulting in excellent water-soluble compound encapsulation efficiency and skin permeability. Therefore, they are useful in cosmetics and topical skin preparations that contain water-soluble cosmetic ingredients. In one embodiment of the present invention, the lipid membrane structures are preferably bicelles. Bicelles are fine, disc-shaped, unilamellar structures with a thickness of 3 to 10 nm and a diameter of 15 to 100 nm, and are excellent in encapsulation efficiency of fat-soluble ingredients and skin permeability. Therefore, they are useful in cosmetics and topical skin preparations that contain fat-soluble cosmetic ingredients. The lipid membrane structure-containing composition of the present invention may contain only one type of unilamellar liposome or bicelles, or these two types may be present together.

[0081] The upper limit of the average particle size of the lipid membrane structures is preferably 200 nm or less, more preferably 140 nm or less, and even more preferably 90 nm or less, from the viewpoints of dispersibility, storage stability, and skin permeability. The lower limit of the average particle size of the lipid membrane structures is not particularly limited, but is, for example, 20 nm or more, from the viewpoint of the efficiency of forming unilamellar structures.

[0082] From the viewpoints of dispersibility, storage stability, and skin permeability, the upper limit of the polydispersity index (PDI) of the lipid membrane structures is preferably 0.80 or less, more preferably 0.50 or less, even more preferably 0.40 or less, still more preferably 0.30 or less, particularly preferably 0.25 or less, and most preferably 0.20 or less. The lower limit of the polydispersity index (PDI) of the lipid membrane structures is not particularly limited, but is, for example, 0.01 or more.

[0083] In this specification, the particle size of the lipid membrane structure refers to the average hydrodynamic diameter. The particle size (average hydrodynamic diameter) and polydispersity index (PDI) of the lipid membrane structure are measured using a dynamic light scattering measurement device (Malvern Instruments, Zetasizer Nano ZSP) and the harmonic mean diameter (Z-Average) and polydispersity index (PDI) based on scattered light intensity by cumulant analysis. The definitions of particle size and polydispersity index used here are as described in "JIS Z8828:2019 Particle Size Analysis - Dynamic Light Scattering Method."

[0084] From the viewpoint of obtaining the skin care effect of the lipid membrane structures, the concentration of the lipid membrane structures in the lipid membrane structure-containing composition of the present invention is preferably 0.0001% by mass or more, more preferably 0.01% by mass or more, and even more preferably 1% by mass or more. On the other hand, the upper limit of the concentration is not particularly limited, but is, for example, less than 5% by mass.

[0085] <Method of producing lipid membrane structure-containing composition> The method for producing the lipid membrane structure-containing composition of the present invention is not particularly limited. It may involve mixing components (A), (B), and (D) in any order and then dispersing the mixture in an aqueous phase containing component (C). Alternatively, it may involve mixing components (A), (B), and, if necessary, a portion of component (C) and a portion of component (D) in any order and then dispersing the mixture in an aqueous phase containing the remaining components (C) and (D). From the viewpoint of improving the dispersibility of the lipid membrane structures, the latter method is preferred. Therefore, a method for producing a lipid membrane structure-containing composition according to one embodiment of the present invention includes the steps of: mixing component (A), component (B), and, if necessary, a portion of component (C) and a portion of component (D) to obtain a mixture (mixing step); and dispersing this mixture in an aqueous phase containing the remaining components (C) and (D) (dispersing step).

[0086] In this case, the content of the component (B) exceeds 100 parts by mass per 100 parts by mass of the component (A).

[0087] In the mixing step of this manufacturing method, the components may be mixed all at once or sequentially. When the components are mixed sequentially, the order in which they are mixed is not particularly limited. For example, when a mixture is produced using component (A), component (B), and optionally a portion of component (C) and a portion of component (D), components (A) and (B) may be mixed, and then a mixture of a portion of component (C) and a portion of component (D) may be added and mixed; or components (A), (B), and a portion of component (C) may be mixed, and then a portion of component (D) may be added and mixed.

[0088] In this production method, the mixing temperature is not particularly limited, but is preferably 25 to 120°C, more preferably 40 to 100°C, and even more preferably 60 to 90°C. The mixing time is also not particularly limited, but is preferably 10 to 60 minutes. The mixing method is not particularly limited, but since it does not require a high level of mechanical shearing force, it can be carried out using known mixing means such as a magnetic stirrer (for example, a hot stirrer), a paddle mixer, a propeller mixer, or a planetary mixer.

[0089] In addition to the mixing step, this production method may also include other steps, such as purification (e.g., filtration), cooling, and storage, as appropriate. It is preferable to use water with few impurities as the aqueous phase, such as purified water, which is purified from tap water using a system that employs ion exchange, distillation, reverse osmosis, or ultrafiltration, either alone or in combination. Furthermore, the aqueous phase may contain components other than water, as long as the lipid membrane structure can be formed. Examples of such components include oils, surfactants, moisturizers, whitening agents, coloring materials, alcohols, amino acids, sugars, vitamins, viscosity modifiers, polymers, colorants, powders, UV absorbers, preservatives, antibacterial agents, antioxidants, fragrances, cosmetic ingredients, electrolytes, fibers, and plant extracts.

[0090] In the dispersion step, the temperature of the aqueous phase is preferably 25 to 100°C, more preferably 40 to 95°C, and even more preferably 60 to 90°C.

[0091] In the dispersing step, the temperature of the mixture to be dispersed is preferably 25 to 120°C, more preferably 40 to 100°C, and even more preferably 60 to 90°C.

[0092] In the method for producing a lipid membrane structure-containing composition according to the present invention, in addition to the above-mentioned mixing and dispersing steps, other steps such as purification (for example, filtration), cooling, and storage may be further carried out.

[0093] <Uses of the lipid membrane structure-containing composition> The lipid membrane structure-containing composition of the present invention can be used as a cosmetic or topical skin preparation by itself, or can be blended into a cosmetic or topical skin preparation to impart skin care effects such as moisturizing and improving skin quality. Therefore, one embodiment of the present invention is a cosmetic containing the lipid membrane structure-containing composition. The types of the cosmetic of the present invention include hair cosmetics, skin cosmetics, makeup cosmetics, and fragrance cosmetics. Examples of the cosmetic product include cosmetics, body cosmetics, etc. Another embodiment of the present invention is an external skin preparation containing the lipid membrane structure-containing composition.

[0094] Hair cosmetics include shampoos such as oil shampoo, cream shampoo, conditioning shampoo, anti-dandruff shampoo, hair color shampoo, and rinse-in-one shampoo; hair care products such as rinse, conditioner, treatment, hair pack, hair mist, and hair oil; hair styling products such as hair foam, hair mousse, hair spray, hair wax, hair gel, hair cream, water grease, setting lotion, pomade, and tic; hair dyes such as color lotion, hair color treatment, hair manicure, and oxidation hair dye; hair tonic, hair liquid, hair blow dryer, split end coat, permanent wave agent, straight perm agent, hair bleach, hair color pre-treatment, hair color after-treatment, perm pre-treatment, perm after-treatment, and hair growth agent.

[0095] Skin cosmetics include lotions such as softening lotion, astringent lotion, cleansing lotion, multi-layered lotion, and liposome lotion; emulsions such as emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizing emulsion, massage lotion, exfoliating smoother, elbow lotion, hand lotion, and body lotion; creams such as emollient cream, nourishing cream, nourishing cream, vanishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, and exfoliating cream; gels such as moisturizing gel, whitening gel, and all-in-one gel; serums such as moisturizing essence, whitening essence, moisturizing serum, and whitening serum; sunscreens such as sun protect, sun protector, UV care milk, and sunscreen; Examples include packs and masks such as peel-off packs, powder packs, washing packs, oil packs and cleansing masks; makeup removers such as cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel and cleansing oil; and facial cleansers such as paste facial cleanser, gel facial cleanser, foam facial cleanser, facial powder, cosmetic soap, transparent soap, medicated soap, liquid soap and shaving soap.

[0096] Examples of makeup cosmetics include lipstick, lip gloss, foundation, blush, powder, concealer, eyeliner, mascara, eye shadow, eyebrow pencil, nail enamel, enamel remover, and nail treatment.

[0097] Examples of the scented cosmetics include perfumes, perfumes, parfums, eau de parfum, eau de toilette, eau de cologne, solid perfumes, scented powders, perfumed soaps, body lotions, and bath oils.

[0098] Examples of body cosmetics include body cleansers such as body shampoos; deodorant cosmetics such as deodorant lotions, deodorant powders, deodorant sprays, and deodorant sticks; bleaches, depilatories, bath additives, and insect repellents such as insect repellent sprays.

[0099] The form of the cosmetic or topical skin preparation of the present invention is not particularly limited as long as the lipid membrane structures can be stably incorporated, and examples thereof include lotion, gel, emulsion, cream, shampoo, facial cleanser, etc. From the viewpoint of taking advantage of the transparent appearance, penetration upon application, and high stability that are achieved by containing the fine lipid membrane structures of the present invention (for example, average particle diameter of 200 nm or less), preferred examples include incorporation into low-viscosity lotions, into which it has been difficult to incorporate lipid membrane structures in the past.

[0100] The concentration of lipid membrane structures in cosmetics and topical skin preparations containing the lipid membrane structure-containing composition of the present invention is preferably 0.0001% by mass or more, more preferably 0.01% by mass or more, and even more preferably 1% by mass or more, from the viewpoint of obtaining the skin care effect of the lipid membrane structures. On the other hand, the upper limit of the concentration is not particularly limited, but is, for example, less than 5% by mass. [Example]

[0101] The effects of the present invention will be explained using the following examples and comparative examples. However, the technical scope of the present invention is not limited to the following examples. In the following examples, unless otherwise specified, operations were performed at room temperature (20 to 25°C). Furthermore, unless otherwise specified, "%" and "parts" mean "% by mass" and "parts by mass", respectively.

[0102] <Preparation of lipid membrane structure-containing composition> A lipid membrane structure-containing composition was prepared by the following method.

[0103] [Examples 1 to 10, Comparative Example 1] Component A, component B or component B', component C, and component D were added to a 100 mL beaker in the amounts shown in Table 1, and the mixture was stirred at 80°C for 20 minutes using a hot stirrer to prepare a lipid membrane structure-containing composition.

[0104] <Evaluation of the composition> [Appearance (composition containing lipid membrane structure)] The appearance of the lipid membrane structure-containing composition prepared above was visually observed at 25°C in a glass bottle with a diameter of 3.7 cm, and evaluated based on the following criteria (◎ or ○ indicates good dispersibility of the lipid membrane structures): ◎: Transparent or semi-transparent liquid in which the text on the opposite side of the container can be seen ○: The letters on the other side of the container are not visible, but the liquid is homogeneous ×: Separation or precipitation is observed Furthermore, the lipid membrane structure-containing composition was stored at 25° C. for one month, and the appearance was observed and evaluated in the same manner as above.

[0105] The results are shown in Table 1 below.

[0106] [Table 1]

[0107] In Table 1 above, component (B) was examined. When a polyol compound corresponding to component (B) was used, lipid membrane structures with an average particle size of 200 nm or less could be formed in all cases (Examples 1 to 10). Furthermore, the lipid membrane structure-containing compositions prepared maintained stability (excellent appearance) even after storage at 25°C for one month. On the other hand, when ethanol, which does not correspond to component (B), was used, it was difficult to form lipid membrane structures (Comparative Example 1).

[0108] [Cryo-TEM observation] The lipid membrane structure-containing composition prepared in Example 7 was subjected to cryo-TEM observation using a transmission electron microscope (Hitachi High-Technologies Corporation, H-7650). As a result, ring-shaped images indicated unilamellar liposome structures, and rod-shaped images indicated bicelle structures, confirming the formation of unilamellar lipid membrane structures (Figure 1).

Claims

1. A lipid membrane structure-containing composition comprising (A) a lipid membrane structure-forming component, (B) a polyol compound, (C) water, and (D) a functional component.

2. The lipid membrane structure-containing composition according to claim 1, wherein the component (A) is a phospholipid.

3. The lipid membrane structure-containing composition according to claim 1, wherein the component (A) is a hydrogenated phospholipid.

4. The lipid membrane structure-containing composition according to any one of claims 1 to 3, wherein the component (B) is a compound represented by the following formula 1: 【Chemical 1】 In the above formula 1, R is a substituted or unsubstituted alkyl group having 2 to 6 carbon atoms or a substituted or unsubstituted cycloalkyl group having 3 to 6 carbon atoms; X is —O—, —C(═O)O—, or —O—C(═O)—; n is 0 or 1.

5. The lipid membrane structure-containing composition according to any one of claims 1 to 3, wherein the component (B) is at least one selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, cyclohexylglycerin, and hexylglycerin.

6. 4. The lipid membrane structure-containing composition according to claim 1, wherein the component (D) is at least one compound selected from the group consisting of oily bases, moisturizers and texture improvers, surfactants, polymers, thickeners and gelling agents, antioxidants, reducing agents, oxidizing agents, antioxidants, whitening agents, vitamins and derivatives thereof, plant, animal and microbial extracts, UV absorbers, antibacterial and preservatives, chelating agents, pH adjusters, acids and alkalis, solvents and propellants, antipruritics, exfoliants and dissolving agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, anti-inflammatory and anti-inflammatory agents, hair growth agents, blood circulation promoters and stimulants, hormones, anti-wrinkle and anti-aging agents, irritation mitigators, cooling agents, warming agents, powders, dyes, colorants, dyes and pigments, and fragrances.

7. The lipid membrane structure-containing composition according to any one of claims 1 to 3, wherein the lipid membrane structures are unilamellar structures.

8. A cosmetic preparation comprising the lipid membrane structure-containing composition according to any one of claims 1 to 3.

9. An external skin preparation comprising the lipid membrane structure-containing composition according to any one of claims 1 to 3.

Images