Topical composition

Abstract

To provide a novel minoxidil-containing topical composition having excellent combability.SOLUTION: An topical composition characterized by containing (a) 3 w / v% or more of minoxidil and (b) a volatile organosilicon compound.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a topical composition containing minoxidil. [Background technology]

[0002] Minoxidil has the chemical name 6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide, and is known to be applicable as a hair growth agent (Patent Document 1), and there have been many reports that it is a drug that exhibits excellent hair growth and hair regrowth effects.

[0003] Since compositions containing minoxidil are used on the scalp daily for a long period of time, there is a demand for formulations that also provide an excellent feeling when used. Preparations with increased concentrations of minoxidil have been reported (Patent Document 2), but they have problems such as poor combability and a poor feel when used.

[0004] In order to solve the above problems, methods of blending higher alcohols or higher fatty acids have been reported (Patent Documents 3 and 4). [Prior art documents] [Patent documents]

[0005] [Patent Document 1] U.S. Patent No. 4,139,619 [Patent Document 2] Japanese Patent Application Laid-Open No. 2001-288090 [Patent Document 3] Japanese Patent Application Publication No. 2020-105217 [Patent Document 4] Japanese Patent Application Laid-Open No. 2016-164146 Summary of the Invention [Problem to be solved by the invention]

[0006] An object of the present invention is to provide a new minoxidil-containing topical composition that is easy to comb through. Another object of the present invention is to provide a minoxidil-containing topical composition that is easy to comb through and has excellent formulation stability. [Means for solving the problem]

[0007] The present inventors conducted extensive research to solve the above problems and discovered that the incorporation of a volatile organosilicon compound improves the combability of a topical composition containing minoxidil, leading to the completion of the present invention. Furthermore, the inventors discovered that the incorporation of a surfactant improves combability and formulation stability, leading to the completion of the present invention.

[0008] That is, the present invention provides: (1) A composition for external use, characterized by containing (a) 3 w / v% or more minoxidil and (b) a volatile organosilicon compound; (2) (c) The topical composition according to (1), which contains a surfactant; (3) (c) The composition for external use according to (2), wherein the surfactant is a nonionic surfactant and / or a cationic surfactant; (4) (c) The topical composition according to (3), wherein the nonionic surfactant is at least one selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene glyceryl fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, sucrose fatty acid ester, and polyoxyethylene sterol; (5) (c) The composition for external use according to (3), wherein the cationic surfactant is at least one selected from the group consisting of aliphatic amidoamine, monoalkyl type, monoalkyl ether type, and benzalkonium type. (6) (d) The composition for external use according to any one of (1) to (5), which contains water; (7) (e) The topical composition according to any one of (1) to (6), which contains a lower alcohol; (8) (f) The composition for external use according to any one of (1) to (7), which contains a polyhydric alcohol; (9) (f) The topical composition according to (8), wherein the polyhydric alcohol is at least one selected from the group consisting of 1,3-butylene glycol, dipropylene glycol, propylene glycol, and glycerin; (10) (g) The composition for external use according to any one of (1) to (9), which contains a polar oil; is. [Effects of the Invention]

[0009] The present invention makes it possible to provide a minoxidil-containing topical composition that is easy to comb and also has excellent formulation stability. [Brief explanation of the drawings]

[0010] [Figure 1] FIG. 1 shows scanning electron microscope (SEM) images (1000x or 500x) of the topical composition of Example 2. [Figure 2] FIG. 2 is a scanning electron microscope (SEM) image (1000x or 500x) of the topical composition of Comparative Example 1. DETAILED DESCRIPTION OF THE INVENTION

[0011] The (a) minoxidil used in the topical composition of the present invention can be of the same quality as that typically used in pharmaceuticals. Furthermore, according to the present invention, the higher the minoxidil content, the greater the problem of combing. Therefore, the higher the concentration of minoxidil in the topical composition, the greater the significance of implementing the present invention. Specifically, the minoxidil content is 3 w / v% to 15 w / v%, more preferably 4 w / v% to 12 w / v%, and even more preferably 5 w / v% to 10 w / v% of the total topical composition of the present invention.

[0012] The volatile organosilicon compound (b) used in the topical composition of the present invention is not particularly limited, but examples include linear silicones with a molecular weight of 100 to 600, cyclic silicones with a molecular weight of 100 to 600, etc. Examples of linear silicones having a molecular weight of 100 to 600 include hexamethyldisiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, dodecamethylpentasiloxane, tetradecamethylhexasiloxane, and hexadecamethylheptasiloxane. Examples of cyclic silicones having a molecular weight of 100 to 600 include octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, and tetradecamethylcycloheptasiloxane. The volatile organosilicon compounds (b) of the present invention may be used singly or in combination of two or more. Among the volatile organosilicon compounds (b) of the present invention, decamethylcyclopentasiloxane and dodecamethylcyclohexasiloxane are preferred. In this invention, "volatile" means that the compound is easily volatilizable at room temperature, ambient temperature, or body temperature, and for example, has a boiling point of 250°C or lower. (b) In terms of the effects of the present invention, the content of the volatile organosilicon compound in the topical composition of the present invention is preferably 0.1 to 8 w / v%, more preferably 0.3 to 5 w / v%, and even more preferably 0.5 to 3 w / v%.

[0013] The topical composition of the present invention may contain a surfactant (c) to enhance combing effectiveness. The surfactant (c) of the present invention is not particularly limited and may include nonionic surfactants, cationic surfactants, anionic surfactants, amphoteric surfactants, etc., with nonionic surfactants and / or cationic surfactants being preferred. Examples of nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid esters, polyethylene glycol fatty acid esters, polyoxyethylene glyceryl fatty acid esters, polyoxyethylene sorbit fatty acid esters, polyoxyethylene alkyl ethers, polyglycerin fatty acid esters, sucrose fatty acid esters, and polyoxyethylene sterols. Preferred examples of polyoxyethylene hydrogenated castor oils include polyoxyethylene hydrogenated castor oil 40, polyoxyethylene hydrogenated castor oil 50, and polyoxyethylene hydrogenated castor oil 60. Preferred examples of polyoxyethylene sorbitan fatty acid esters include polyoxyethylene sorbitan monostearate and polyoxyethylene sorbitan trioleate, with the average number of moles of polyoxyethylene chains preferably being 20. Preferred examples of polyethylene glycol fatty acid esters include polyethylene glycol monostearate, polyethylene glycol monooleate, and polyethylene glycol monolaurate, with the average number of moles of polyoxyethylene chains preferably being 10. Preferred examples of polyoxyethylene glyceryl fatty acid esters include polyoxyethylene glyceryl monostearate, with the average number of moles of polyoxyethylene chains preferably being 15. Preferred examples of polyoxyethylene sorbit fatty acid esters include polyoxyethylene sorbit tetraoleate, with the average number of moles of polyoxyethylene chains preferably being 30 to 60. Preferred examples of polyoxyethylene alkyl ethers include polyoxyethylene cetyl ether and polyoxyethylene oleyl ether, with the average number of moles of polyoxyethylene chains preferably being 4 to 10. The polyglycerin fatty acid ester is preferably polyglyceryl monostearate or polyglyceryl monooleate, and the average degree of polymerization of glycerin is preferably 10. The sucrose fatty acid ester is preferably sucrose stearate. The polyoxyethylene sterol is preferably PEG30-phytosterol. The cationic surfactants include aliphatic amidoamine, monoalkyl type, monoalkyl ether type, and benzalkonium type, and preferred are aliphatic amidoamine and monoalkyl type. As the aliphatic amidoamine, stearamidopropyl dimethylamine and behenamidopropyl dimethylamine are preferred, and as the monoalkyl type, cetrimonium chloride, steartrimonium chloride, behentrimonium chloride and steartrimonium bromide are preferred. These surfactants may be used alone or in combination of two or more. In terms of the effects of the present invention, the content of the surfactant in the topical composition of the present invention is preferably 0.1 to 15 w / v%, more preferably 0.1 to 10 w / v%, even more preferably 0.5 to 8 w / v%, and particularly preferably 1 to 5 w / v%.

[0014] The content of (d) water in the topical composition of the present invention is preferably 1 to 75 w / v %, more preferably 5 to 50 w / v %, and even more preferably 8 to 30 w / w %.

[0015] The lower alcohol (e) used in the topical composition of the present invention preferably has 1 to 5 carbon atoms, such as ethanol or isopropanol, and these may be used in combination. The content of the lower alcohol in the topical composition of the present invention is preferably greater than 20 w / v%, more preferably 35 w / v% or more, and even more preferably 50 w / v% or more. The upper limit is preferably 80 w / v%, more preferably 70 w / v%.

[0016] Examples of the polyhydric alcohol (f) used in the topical composition of the present invention include 1,3-butylene glycol, dipropylene glycol, propylene glycol, glycerin, etc., which may be used alone or in combination. The content of the polyhydric alcohol in the topical composition of the present invention is preferably 2 to 50 w / v%, more preferably 5 to 35 w / v%.

[0017] The incorporation of a (g) polar oil in the topical composition of the present invention enhances the low-temperature stability of the minoxidil-containing composition of the present invention. Examples of the (g) polar oil of the present invention include diisopropyl adipate, diisopropyl sebacate, diethyl sebacate, cetyl ethylhexanoate, ethyl olivate, decyl isostearate, isopropyl myristate, isopropyl palmitate, myristyl myristate, cetyl palmitate, octyldodecyl myristate, triethylhexanoin, propylene glycol monocaprylate, and propylene glycol dicaprylate, and these may be used alone or in combination. The (g) polar oil of the present invention is non-volatile. The amount of the (g) polar oil in the topical composition of the present invention is preferably 0.05 to 8 w / v%, more preferably 0.1 to 5 w / v%, and even more preferably 0.2 to 2 w / v%. When the topical composition of the present invention contains (g) a polar oil, the low-temperature stability of the minoxidil-containing composition is further improved.

[0018] The topical composition of the present invention may contain a pH adjuster, if necessary. Examples of pH adjusters include phosphoric acid, citric acid, lactic acid, tartaric acid, hydrochloric acid, acetic acid, boric acid, etc., and these may be used alone or in combination. From the viewpoints of the stability of the active ingredient minoxidil, the sensation of irritation to the skin during use, drug penetration, and usability, it is preferable to adjust the pH of the topical composition of the present invention to a range of 4 to 9.5, and more preferably a range of 5.5 to 7.0.

[0019] In addition to the above-mentioned components, the topical composition of the present invention may contain other necessary active ingredients and auxiliary ingredients within the scope of not impairing the effects of the present invention. Examples of medicinal ingredients that are preferably added or incorporated into the topical composition of the present invention include one or more components selected from the group consisting of menthol, vitamin E acetate, pantothenyl ethyl ether, hinokitiol, pyridoxine hydrochloride, glycyrrhetinic acid, diphenhydramine hydrochloride, panthenol, retinol palmitate, nicotinamide, and allantoin. There are no particular restrictions on the amounts of these optional ingredients added, and they can be determined experimentally, taking into consideration the feel when used, the stability of minoxidil, the composition of the solvent system, and the like.

[0020] In addition to the above-mentioned components, the topical composition of the present invention can contain various active ingredients and auxiliary ingredients used in general topical preparations, provided that the effects of the present invention are not impaired. For example, excipients, hair growth ingredients (6-benzylaminopurine, adenosine, pentadecanoic acid glyceride, Polygonum polyglutamum, etc.), vasodilators (carpronium chloride, benzyl nicotinate, Swertia japonica extract, Panax ginseng extract, ginseng tincture, capsicum tincture, etc.), antihistamines (isothipendyl hydrochloride, etc.), anti-inflammatory agents (guaiazulene, etc.), keratolytic agents (urea, salicylic acid, etc.), disinfectants (chlorhexidine gluconate, isopropylmethylphenol, quaternary ammonium salts, piroctone olamine, etc.), moisturizers (hyaluronic acid or its salts, chondroitin sulfate, etc.), various plants and animals (yew, moutan pith, licorice, St. John's wort, aconite, loquat, artemisonia capillaris, konjac, etc.), It can contain commonly used ingredients such as extracts of (e.g., Angelica keiskei, saffron, Sanshishi, rosemary, sage, Mukkou, Seimokkou, hops, placenta, saw palmetto, pumpkin seed, etc.), vitamins (retinol acetate, ascorbic acid, thiamine nitrate, cyanocobalamin, biotin, etc.), antioxidants (dibutylhydroxytoluene, sodium metabisulfite, tocopherol, sodium edetate, ascorbic acid, isopropyl gallate, etc.), solubilizers (various vegetable oils, various animal oils, alkyl glyceryl ethers, hydrocarbons, etc.), metabolic activators, gelling agents (water-soluble polymers, etc.), adhesives, fragrances, fresheners (peppermint oil, camphor, etc.), dyes, etc.

[0021] The topical composition of the present invention can be prepared by incorporating the above-mentioned components in a conventional manner.

[0022] The thus obtained external composition of the present invention can be used as a skin application preparation such as a hair preparation, eyelash preparation, or eyebrow preparation.

[0023] EXAMPLES The present invention will be explained in more detail below with reference to Examples, Comparative Examples and Test Examples, but the present invention is not limited to these Examples in any way. [Example]

[0024] (Examples 1 to 6, Comparative Example 1, and Reference Example 1) The components listed in Table 1 were mixed, stirred and dissolved to prepare the topical compositions of Examples 1 to 6, Comparative Example 1 and Reference Example 1.

[0025] [Table 1] * Decamethylcyclopentasiloxane 5-NF (manufactured by DuPont Toray Specialty Materials Co., Ltd.; a mixture of decamethylcyclopentasiloxane and dodecamethylcyclohexasiloxane)

[0026] <Test Example 1: Preparation test of topical composition, combing test> Preparation tests of topical compositions were carried out for Examples 1 to 6, Comparative Example 1, and Reference Example 1. A test in which all of the formulated ingredients were dissolved was marked with a circle, and a test in which some ingredients were insoluble was marked with an X. A combing test was also carried out using hair bundle samples (3 g, 100% human black hair, Beaulux) from Examples 1 to 6, Comparative Example 1, and Reference Example 1. 0.05 mL / 20 cm of the formulation was applied to a dry hair bundle. 2 The formulation was applied to a 4cm x 5cm area, and combability was evaluated 12 to 24 hours after application. A metal comb (φ1mm, pitch 1mm) was used. Combability was scored on a four-point scale of 1 (no resistance), 2 (almost no resistance), 3 (resistance), and 4 (considerable resistance), and evaluation was performed twice. The average value was calculated, and the difference from Comparative Example 1 was used as the combability improvement score. The results are shown in Table 2.

[0027] [Table 2]

[0028] In the topical compositions of Examples 1 to 6 and Comparative Example 1, all of the ingredients dissolved, resulting in clear topical compositions without precipitates. The combing improvement score for Example 1 was 1.0, and by incorporating a volatile organosilicon compound, combing was improved to the same extent as in Reference Example 1 (the composition of Example 1 described in paragraph 0021 of Patent Document 3 (JP 2020-105217 A), a prior art). The combing improvement scores for Examples 2 to 6 were 1.0 to 2.0, and by further incorporating a surfactant in Example 1, combing was improved to the same extent as in Reference Example 1 or significantly improved.

[0029] <Test Example 2: Evaluation of adhesion of topical composition to hair> For Example 2 and Comparative Example 1, 0.03 mL / 4 cm of the preparation was applied to a dry hair bundle sample (10 g, 100% human black hair, Beaulux). 2 The formulation was applied to a 4 cm x 1 cm area. 12 to 24 hours after application, a portion of the hair to which the formulation had adhered was cut out and observed using a tabletop low-vacuum scanning electron microscope (Miniscope (registered trademark) TM-1000, Hitachi High-Technologies Corporation) (SEM). SEM photographs (1000x and 500x magnifications) of Example 2 are shown in Figure 1, and SEM photographs (1000x and 500x magnifications) of Comparative Example 1 are shown in Figure 2.

[0030] 1 and 2, it was observed that the topical composition of Example 2 adhered to the hair with gaps. On the other hand, it was observed that the topical composition of Comparative Example 1 adhered over a wide area, bridging the hair strands. From the above, it is thought that the change in the adhesion of the preparation to the hair may contribute to the improvement in combing.

[0031] (Examples 7 to 15, Comparative Example 2) The components listed in Table 3 were mixed, stirred and dissolved to prepare the topical compositions of Examples 7 to 15 and Comparative Example 2.

[0032] [Table 3]

[0033] <Test Example 3: Preparation test of topical composition, combing test> Preparation tests of topical compositions were carried out for Examples 7 to 15 and Comparative Example 2. A mark of "O" was given when all of the ingredients were dissolved, and a mark of "X" was given when some ingredients were insoluble. A combing test was also carried out using hair bundle samples (3 g, 100% human black hair, Beaulux Co., Ltd.) from Examples 7 to 15. 0.05 mL / 20 cm of the formulation was applied to a dry hair bundle. 2 The formulation was applied to a 4cm x 5cm area, and combability was evaluated 12 to 24 hours after application. A metal comb (φ1mm, pitch 1mm) was used. Combability was scored on a four-point scale of 1 (no resistance), 2 (almost no resistance), 3 (resistance), and 4 (considerable resistance), and evaluation was performed twice. The average value was calculated, and the difference from Comparative Example 2 was used as the combability improvement score. The results are shown in Table 4.

[0034] [Table 4]

[0035] As is clear from Table 4, the topical compositions of Examples 7 to 15 dissolved all of the ingredients, resulting in clear topical compositions free of precipitates. On the other hand, Comparative Example 2, which contained dimethylsiloxane, a non-volatile oily ingredient, failed to dissolve all of the ingredients. Furthermore, the combing improvement scores of Examples 13 and 14 were 1.0 and 0.5, respectively, showing improvements comparable to those of Reference Example 1. On the other hand, the combing improvement scores of Examples 7 to 12 and Example 15 were 1.5 or higher, showing significant improvements in combing.

[0036] <Test Example 4: Evaluation of low temperature stability> Each of Examples 7 to 15 was filled into a transparent glass screw tube, and after storage at 5°C for 7 days, the presence or absence of precipitation of the compounded ingredients was visually evaluated. After low-temperature storage, the topical composition of Example 7 precipitated oil droplets to a degree that did not pose a problem in the preparation of the formulation. On the other hand, the topical compositions of Examples 8 to 15 did not precipitate even after low-temperature storage, resulting in more favorable results.

[0037] (Examples 16 to 18) The components listed in Table 5 were mixed, stirred and dissolved to prepare the topical compositions of Examples 16 to 18.

[0038] [Table 5]

[0039] <Test Example 5: Preparation test of topical composition, combing test> Preparation tests of topical compositions were carried out for Examples 16 to 18. A mark of "O" was given when all of the ingredients were dissolved, and a mark of "X" was given when some ingredients were insoluble. A combing test was also carried out using hair bundle samples (3 g, 100% human black hair, Beaulux Co., Ltd.) from Examples 16 to 18. 0.05 mL / 20 cm of the formulation was applied to a dry hair bundle. 2 The formulation was applied to a 4cm x 5cm area, and combability was evaluated 12 to 24 hours after application. A metal comb (φ1mm, pitch 1mm) was used. Combability was scored on a four-point scale of 1 (no resistance), 2 (almost no resistance), 3 (resistance), and 4 (considerable resistance), and evaluation was performed twice. The average value was calculated, and the difference from Comparative Example 2 was used as the combability improvement score. The results are shown in Table 6.

[0040] [Table 6]

[0041] As is clear from Table 6, all of the ingredients in the topical compositions of Examples 16 to 18 were dissolved, resulting in clear topical compositions without precipitates. The combing improvement score for Example 16 was 1.0, which was an improvement comparable to that of Reference Example 1. On the other hand, the combing improvement scores for Examples 17 and 18 were 1.5 or higher, showing a significant improvement in combing.

[0042] <Test Example 6: Evaluation of low temperature stability> Each of Examples 16 to 18 was filled into a transparent glass screw tube and stored at 5°C for 7 days, after which the presence or absence of precipitation of the blended ingredients was visually evaluated. The topical compositions of Examples 16 to 18 did not exhibit precipitation even after low-temperature storage, which was a favorable result.

[0043] (Prescription Example 1) A composition for external use was prepared by mixing 5 g of minoxidil, 5 g of 1,3-butylene glycol, 10 g of glycerin, 53 g of ethanol, 0.3 g of l-menthol, 0.05 g of hinokitiol, 0.08 g of vitamin E acetate, 0.04 g of retinol palmitate, 0.1 g of allantoin, 0.1 g of glycyrrhetinic acid, 0.1 g of diphenhydramine hydrochloride, 0.5 g of decamethylcyclopentasiloxane 5-NF, 4 g of polyethylene glycol monolaurate, 0.25 g of isopropyl myristate, an appropriate amount of antioxidant, an appropriate amount of citric acid, purified water to a total volume of 100 mL, and stirring to obtain a composition for external use.

[0044] (Prescription example 2) A composition for external use was prepared by mixing 5 g of minoxidil, 5 g of 1,3-butylene glycol, 10 g of glycerin, 53 g of ethanol, 0.3 g of l-menthol, 0.05 g of pyridoxine hydrochloride, 0.08 g of vitamin E acetate, 1 g of panthenol, 0.1 g of allantoin, 0.1 g of glycyrrhetinic acid, 0.1 g of diphenhydramine hydrochloride, 0.5 g of decamethylcyclopentasiloxane 5-NF, 4 g of polyethylene glycol monolaurate, 0.25 g of diisopropyl adipate, an appropriate amount of antioxidant, an appropriate amount of citric acid, and purified water to a total volume of 100 mL, and dissolving the mixture with stirring.

[0045] Another embodiment of the topical composition may contain, for example, 0.1 to 10 w / v% minoxidil, 2 to 30 w / v% 1,3-butylene glycol, 1 to 30 w / v% glycerin, 20 to 70 w / v% ethanol, 0.001 to 1 w / v% antioxidant (dibutylhydroxytoluene, dibutylhydroxyanisole, sodium metabisulfite, sodium edetate, or propionyl gallate), and other active ingredients or auxiliary ingredients such as 0.1 to 5 w / v% menthol, 0.001 to 1 w / v% vitamin E acetate, and 0.001 to 1 w / v% pyridoxine hydrochloride. Examples of formulations include: 1-1 w / v%, diphenhydramine hydrochloride 0.001-1 w / v%, pantothenyl ethyl ether or panthenol 0.1-10 w / v%, allantoin 0.001-1 w / v%, glycyrrhetinic acid 0.001-1 w / v%, isopropylmethylphenol 0.001-1 w / v%, hinokitiol 0.001-1 w / v%, an appropriate amount of citric acid and / or phosphoric acid, glycine 0.00001-1 w / v%, and L-arginine 0.00001-1 w / v%, with the remainder made up with water and filled into a PET container. These active ingredients and auxiliary ingredients can be appropriately blended taking into consideration the usability, stability of minoxidil, solvent composition, etc. Formulation examples of these topical compositions are shown in Table 7.

[0046] [Table 7] [Industrial Applicability]

[0047] The present invention makes it possible to provide a minoxidil-containing topical composition for hair growth that has an increased concentration of minoxidil and that allows for easy combing.

Claims

1. A topical composition comprising (a) 3 w / v% or more minoxidil, and (b) a volatile organosilicon compound.

2. The topical composition according to claim 1, further comprising (c) a surfactant.

3. The topical composition according to claim 2, wherein (c) the surfactant is a nonionic surfactant and / or a cationic surfactant.

4. The topical composition according to claim 3, wherein (c) the nonionic surfactant is at least one selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene glyceryl fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, sucrose fatty acid ester, and polyoxyethylene sterol.

5. The topical composition according to claim 3, wherein (c) the cationic surfactant is at least one selected from the group consisting of aliphatic amidoamine, monoalkyl type, monoalkyl ether type, and benzalkonium type.

6. The topical composition according to claim 1 or 2, which contains (d) water.

7. The topical composition according to claim 1 or 2, which contains (e) a lower alcohol.

8. The topical composition according to claim 1 or 2, which contains (f) a polyhydric alcohol.

9. The topical composition according to claim 8, wherein (f) the polyhydric alcohol is at least one selected from the group consisting of 1,3-butylene glycol, dipropylene glycol, propylene glycol, and glycerin.

10. The topical composition according to claim 1 or 2, which contains (g) a polar oil.

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