Antiperspirant / deodorant for underarms

Abstract

To provide a safe antiperspirant / deodorant for underarms which has high antiperspirant / deodorant effect, and does not cause skin irritation and rash.SOLUTION: An antiperspirant / deodorant for underarms has lactate contained in ethanol aqueous solution.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an agent for preventing underarm odor. [Background technology]

[0002] It is known that the cause of axillary odor is that when sweat secreted from the apocrine sweat glands in the armpits is released onto the skin, it mixes with oil secreted from the sebaceous glands and sweat secreted from the eccrine sweat glands, and is then broken down by the bacteria resident on the skin, producing substances that cause axillary odor.

[0003] It is said that sweat is mostly water, over 99%, with other components including sodium chloride (about 0.65%), urea, lactic acid, and trace amounts of electrolytes such as potassium, ammonia, calcium, magnesium, and heavy carbon ions.

[0004] Conventional methods for preventing axillary odor include surgical treatment to remove the apocrine sweat glands in the armpits, and conservative treatments such as applying anti-armpit odor agents to the armpits that inhibit the activity of the apocrine sweat glands.

[0005] On the other hand, focusing on the normal flora of the skin, a method has also been used in which an aqueous solution of ethanol or isopropanol is applied to the armpits to kill the normal flora of the skin. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Japanese Patent Application Laid-Open No. 2001-288063 [Patent Document 2] Japanese Patent Application Laid-Open No. 2002-284658 Summary of the Invention [Problem to be solved by the invention]

[0007] Surgical treatment to remove apocrine sweat glands not only poses psychological resistance, but also requires hospitalization and outpatient visits, which significantly restricts free activities of daily life. Furthermore, complete removal is difficult because removal scars remain, and because apocrine sweat glands are located inside the skin, some may remain, and apocrine sweat glands may even regrow.

[0008] Furthermore, even when anti-armpit odor agents that inhibit apocrine sweat gland activity, which is one of the conservative treatments, are used, they have not been sufficiently effective. Furthermore, while anti-armpit odor agents that kill resident skin bacteria have been shown to have a certain effect on the beneficial bacteria that are resident on the skin, they are ineffective against the harmful bacteria that play a particularly important role in the mechanism of armpit odor.

[0009] Therefore, an object of the present invention is to provide an agent for preventing underarm odor that kills harmful bacteria, among the normal bacteria present on the skin. [Means for solving the problem]

[0010] In order to solve the above problems, the present invention provides: (1) An agent for preventing underarm odor, characterized by containing lactate in an aqueous ethanol solution. Also, (2) The underarm odor prevention agent according to (1), characterized in that it contains lactate in an amount of 0.1 to 30 mass percent. moreover, (3) The underarm odor prevention agent according to (1), characterized in that it contains lactate in an amount of 0.5 to 1.5 mass percent. is. [Effects of the Invention]

[0011] The present invention can effectively prevent underarm odor and can be used safely. DETAILED DESCRIPTION OF THE INVENTION

[0012] The effects of the present invention will be explained below by giving test examples.

[0013] [Test 1] (Skin resident bad bacteria sterilization test) (1) Products used as underarm odor inhibitors ▲1▼ Lactate: A mixture of lactic acid and lactic acid polycondensates, containing 90% lactic acid (C3H6O3) ("Food Additive Lactic Acid" 50ml, Kenei Pharmaceutical Co., Ltd.) 2. Ethanol: Contains 76.9-81.4% by volume of ethanol (C2H6O:46.07) at 15°C ("Disinfectant Ethanol 'Metal' 500ml, Nakakita Pharmaceutical Co., Ltd.")

[0014] (2) Preparation of anti-armpit odor agent (base) 3.5 ml of (1) lactate was measured using a 5.0 ml cylinder, and 496.5 ml of (2) ethanol was measured using a 500 ml cylinder. The two were mixed by stirring to prepare a 0.70% by mass anti-armpit odor agent (base). The solutions of the anti-armpit odor agent used in Test 1 were prepared by adding 0.70 mass % of the anti-armpit odor agent (base material) as is or an appropriate amount of (1) lactate or (2) ethanol.

[0015] (3) Preparation of agar medium 4g of powdered agar, 2g of potato starch, and 400ml of water were mixed and heated. After the mixture had dissolved and become colorless and transparent, it was poured into a sample container (7-8cm diameter) to a thickness of 1-2cm. The mixture was left at room temperature until it solidified, and this was used as the agar medium.

[0016] (4) Test method First, colorless skin bacteria were scraped off from the armpits of subjects with axillary odor over a period of 2 to 3 seconds using food wrap wrapped around the index, middle, and ring fingers to increase the contact area. Next, the wrap film was sprayed twice (approximately 0.2 cc / twice) with the anti-armpit odor agent of each concentration, which had been prepared in a 10 cc spray container, and then (or left as is) rubbed onto the center of the agar medium prepared in (3). After leaving (cultivating) the specimens at room temperature for the specified number of days, the presence or absence of colorless resident skin bacteria was examined by coloration using a 10-fold diluted solution of commercially available mouthwash (containing iodine).

[0017] When iodine solution is added to starch, the chemical reaction that turns it blue or red is called the iodine starch reaction. Starch is a carbohydrate that plants store in their bodies through photosynthesis, and the starch extracted from dogtooth violets is potato starch. In this test, if a 10-fold diluted solution of commercially available mouthwash turned blue-purple, it was determined that the iodine-starch reaction had occurred, and the resident skin bacteria rubbed onto the center of the agar medium had been killed by the anti-armpit odor agent. Conversely, if the solution remained colorless and transparent rather than turning blue-purple, it was determined that the iodine-starch reaction had not occurred, and the resident skin bacteria had been cultured.

[0018] (5) Test conditions (A) Sample types: No. 1 (0.50% lactate solution), No. 2 (0.70% lactate solution), No. 3 (1.00% lactate solution), No. 4 (1.50% lactate solution), No. 5 (Comparative Example 1 (100% ethanol solution)), No. 6 (Comparative Example 2 (as is)). (a) Culture period: 3 days, 5 days, and 10 days

[0019] (6) Test results For each type of sample after each number of days of culture, the observation results were evaluated into three levels: "○" (no white area (i.e., the normal skin bacteria were killed)), "△" (it was difficult to determine whether or not there was a white area), and "×" (white area was present (i.e., the normal skin bacteria were cultured)) (some combinations were not performed). The observation results and photographs are shown in Table 1 below. [Table 1]

[0020] [Test 2] (Axillary Odor Prevention Test A) (1) Test method One subject with armpit odor was sprayed twice with [Test 1] (1)▲1▼ lactate (undiluted solution) in a 10cc spray container into the left armpit, and the right armpit was left as is, and the armpit odor of each subject was evaluated one day later. The evaluation method was to rate the odor of the left armpit as either "effective" or "ineffective" compared to the odor of the right armpit.

[0021] (2) Test results One subject responded that the application of the lactate (undiluted solution) to the left armpit was "effective" and prevented armpit odor compared to the left armpit left untouched. However, he reported that he had developed a skin rash in his left armpit, which caused the skin to peel and remain itchy.

[0022] [Test 3] (Axillary Odor Prevention Test B) (1) Test method The same subject as in [Test 2] was sprayed twice with the 0.70% lactate solution prepared in [Test 1] (2) in a 10 cc spray container into the right armpit, and the left armpit was left as is. One day later, the axillary odor of each subject was evaluated. The evaluation method was to rate the right armpit odor as either "effective" or "ineffective" compared to the left armpit odor.

[0023] (2) Test results One subject responded that the right armpit to which the 0.70% lactate solution was applied was "effective" and prevented armpit odor compared to the left armpit which was left untreated. He also stated that the skin in his right armpit did not peel or itch.

[0024] [Test 4] (Axillary Odor Prevention Test C) (1) Test method Two subjects with axillary odor other than the one subject in [Test 2] were given the 0.70% lactate solution prepared in [Test 1] (2) in a 10 cc spray container and instructed to spray it twice into each armpit.

[0025] (2) Test results Both subjects reported that their armpit odor had disappeared, unlike the day before the test. They also reported that they had not experienced any changes in their armpits that would cause a skin rash.

[0026] From the above, it was confirmed that the lactate of the present invention contained in an aqueous ethanol solution has the effect of preventing axillary odor.

Claims

1. An anti-armpit odor agent characterized by containing lactate in an ethanol aqueous solution.

2. 2. The underarm odor prevention agent according to claim 1, wherein lactate is contained in an amount of 0.1 to 30 mass percent.

3. 2. The underarm odor prevention agent according to claim 1, wherein lactate is contained in an amount of 0.5 to 1.5 mass percent.

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