Syringe with vial

Abstract

To provide a safe syringe with a vial capable of easily taking out an arbitrary amount of a liquid body from a sealed vial and filling it.SOLUTION: In a syringe with a plunger of the syringe as a vial, a movable sealing member inside the vial has a penetration part penetrating the movable sealing member inside the vial, and the penetration does not depend on the directionality of the longitudinal direction of the vial, and the syringe with the vial is opened according to the pressure to the movable sealing member inside the vial, and is closed when the pressure to the movable sealing member inside the vial is released. An injection needle, a syringe vial adapter body, a connecting cylindrical member, a vial inside movable sealing member, and the vial can be detachably and closely connected to each other.SELECTED DRAWING: Figure 2

Description

[Technical Field]

[0001] The present invention relates to a syringe with a vial. [Background technology]

[0002] Vials containing liquid medicines are used in medical settings, research and development, etc. A rubber cap is attached to the top of the vial to prevent leakage of the liquid medicine inside. A syringe needle is inserted into the cap to draw up the liquid medicine into the syringe. The following prior art has been proposed in relation to the technology for handling such vials.

[0003] Prior art 1 discloses a technique in which the plunger rod of a syringe is replaced with a vial filled with a liquid medicine (Patent Document 1). According to this prior art, a vial insertion needle separate from the injection needle is installed inside the syringe body, and the plunger rod of the syringe can be pushed toward the distal end of the syringe to discharge the liquid medicine sealed inside the plunger rod toward the distal end of the syringe.

[0004] Meanwhile, a check valve known as a duckbill valve is commonly known as another prior art 2. A duckbill valve has a slit or an umbrella-shaped valve inside, which opens when gas or liquid passes through it, and closes when the flow of gas or liquid stops, allowing fluids such as gas or liquid to flow in one direction. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Special Publication No. 5-60952 Summary of the Invention [Problem to be solved by the invention]

[0006] However, in the case of the above-mentioned Prior Art 1, it is necessary to push the plunger rod containing the vial toward the vial insertion needle installed inside the syringe body, which requires the user to bring their finger close to the needle. Although the syringe body is usually made of a material with sufficient strength, and therefore the possibility of the syringe body being damaged is low, bringing their finger close to the needle is not desirable from the perspective of safety management.

[0007] A syringe typically includes a needle, a syringe barrel, a plunger rod, and a sealing member made of elastic resin attached to the tip of the plunger rod. With the needle of the syringe inserted into the rubber cap of a vial, problems arise when sucking up a liquid medicine or the like from the vial into the syringe, and when filling the vial with the liquid medicine or the like. For example, suppose that the sealing member made of elastic resin of the syringe moves from a state in contact with the distal end inside the syringe barrel body, i.e., the side where the injection needle is attached, to a state in contact with the proximal end inside the syringe barrel body, i.e., the side opposite to the side where the injection needle is attached. In this case, unless the vial is replenished with the same volume of air as the volume displaced by the elastic resin sealing member of the syringe inside the syringe barrel body, the elastic resin sealing member of the syringe will return to the distal end inside the syringe barrel body when the plunger rod attached to the syringe barrel body is released, making it impossible to efficiently draw up the medicinal liquid into the syringe barrel body.

[0008] Conversely, when filling a vial with a liquid, unless there is a mechanism for effectively releasing the air inside the vial to the outside, it becomes difficult to fill the vial with a liquid medicine or the like from the outside.

[0009] On the other hand, the check valve known as a duckbill valve in Prior Art 2 described above is designed to allow fluids such as liquids and gases to flow in one direction, so even if Prior Art 1 and Prior Art 2 were combined, it would be difficult to introduce or remove liquids into or from the vial.

[0010] An object of the present invention is to provide a safe syringe with a vial that can easily dispense any amount of liquid from a sealed vial and can also be filled with the liquid. [Means for solving the problem]

[0011] As a result of intensive research by the present inventors to solve the above problems, they found that among syringes in which the syringe plunger is a vial, a syringe with a vial in which the movable sealing member inside the vial has a penetration part that penetrates the movable sealing member inside the vial, and this penetration part opens in response to pressure on the movable sealing member inside the vial without being dependent on the longitudinal direction of the vial, and closes when the pressure on the movable sealing member inside the vial is released, meets the object of the present invention, and they have completed the present invention.

[0012] That is, the present invention provides: [1] A syringe vial adapter comprising: a syringe needle; a syringe vial adapter body; a connecting cylindrical member; a vial internal movable sealing member; and a vial; The inside of the syringe vial adapter body is cylindrical, the syringe vial adapter body has a syringe needle attachment portion on a distal end side and a vial attachment portion on a proximal end side, the syringe vial adapter body has a conductive cylindrical portion therein that communicates with the injection needle attachment portion on the distal end side, the connecting tubular member has a connecting portion for a conductive tubular member on a distal end side and a connecting portion for a vial internal movable sealing member on a proximal end side, the conductive cylindrical portion of the syringe vial adapter body is installed in the conductive cylindrical portion connecting portion on the distal end side of the connecting cylindrical member, the vial internal movable sealing member is installed at a vial internal movable sealing member connecting portion on the proximal end side of the connecting tubular member; The side surface of the vial interior movable sealing member is movably in close contact with the inner surface of the vial, the vial is movably installed in a vial mounting portion on the proximal end side of the syringe vial adapter body, The injection needle is installed in the injection needle mounting portion of the syringe vial adapter body, the syringe needle, the conductive cylindrical portion of the syringe vial adapter body, and the connecting cylindrical member are linearly and closely connected to each other with respect to the longitudinal direction of the syringe vial adapter body; the vial interior movable sealing member has a through-hole that penetrates the vial interior movable sealing member in the up-and-down direction with respect to the longitudinal direction of the syringe vial adapter body, The syringe with a vial is characterized in that the penetration part opens in response to pressure on the movable sealing member inside the vial and closes when the pressure on the movable sealing member inside the vial is released.

[0013] Another aspect of the present invention is [2] The present invention provides the vial-equipped syringe according to the above [1], wherein the penetration portion is at least one of a notch and an opening slit.

[0014] Another aspect of the present invention is [3] The present invention provides a syringe with a vial according to the above [2], in which the injection needle, the syringe vial adapter body, the connecting cylindrical member, the vial internal movable sealing member, and the vial can be detachably and tightly connected to each other.

[0015] Another aspect of the present invention is [4] The side of the movable sealing member inside the vial is kept in close contact with the inner surface of the vial. The present invention provides a syringe with a vial according to the above item [3], in which the vial can be inserted into the syringe vial adapter body while being held by the user.

[0016] The present invention also provides [5] inserting the vial into the syringe vial adapter body while maintaining a state in which the side of the vial interior movable sealing member is in close contact with the inner surface of the vial; a penetration portion of the vial internal movable sealing member that opens in response to pressure on the vial internal movable sealing member and closes when the pressure on the vial internal movable sealing member is released; The present invention provides a method for delivering a liquid material using the vial-equipped syringe according to any one of [1] to [4] above. [Effects of the Invention]

[0017] With the vial-equipped syringe of the present invention, anyone can easily dispense any amount of liquid from the vial to the outside by simply attaching the vial containing the liquid and inserting the vial into the syringe vial adapter body. The amount of liquid discharged to the outside can be seen by looking at the syringe, so any desired amount of liquid can be easily discharged to the outside. Even when a vial is attached to the vial-equipped syringe according to the present invention, the movable sealing member inside the vial has a through-hole that penetrates the movable sealing member inside the vial in the vertical direction based on the longitudinal direction of the syringe vial adapter body, and therefore, the liquid can be easily discharged from inside the vial or filled into the vial through this through-hole. In addition, in the case of the syringe with a vial according to the present invention, the gas inside the vial can be released to the outside through the penetration part, so that after the liquid material is poured into the vial, the movable vial internal sealing member used in the present invention can be easily attached to the vial. [Brief explanation of the drawings]

[0018] [Figure 1] FIG. 1 is a schematic perspective view illustrating the relationship between a syringe needle, a syringe vial adapter body, a connecting tubular member, a vial internal movable sealing member, and a vial, which are used in the invention according to embodiment 1 of the present invention. [Figure 2] FIG. 2 is a schematic partial cross-sectional view for explaining the operation of the vial-equipped syringe 100 according to the first embodiment of the present invention. [Figure 3] FIG. 3 is a schematic partial cross-sectional view for explaining the operation of the vial-equipped syringe 100 according to the first embodiment of the present invention. [Figure 4] FIG. 4 is a schematic diagram illustrating a vial internal movable sealing member 60 used in the second embodiment of the present invention. [Figure 5] FIG. 5 is a schematic partial cross-sectional view illustrating a state in which a vial interior movable sealing member 60 used in the second embodiment of the present invention is inserted into a vial 30. As shown in FIG. DETAILED DESCRIPTION OF THE INVENTION

[0019] The present invention will be described in detail below based on embodiments with reference to the drawings, but the present invention is not limited to the contents of the following embodiments.

[0020] [Embodiment 1] FIG. 1 is a schematic perspective view illustrating the relationship between a syringe needle, a syringe vial adapter body, a connecting tubular member, a vial internal movable sealing member, and a vial, which are used in the invention according to embodiment 1 of the present invention. The vial-equipped syringe 100 according to the first embodiment of the present invention is formed by a syringe vial adapter body 1, a connecting tubular member 11, a vial inner movable sealing member 20, a vial 30, and an injection needle 50.

[0021] The syringe vial adapter body 1 illustrated in Fig. 1 is made of one or more of organic materials such as synthetic resin, inorganic materials such as glass and ceramic, and metal materials such as stainless steel. The syringe vial adapter body 1 is preferably made of synthetic resin because it is easy to process and has excellent impact resistance. Furthermore, it is more preferable that the syringe vial adapter body 1 be made of a transparent material so that the contents can be visually confirmed.

[0022] The syringe vial adapter body 1 has a syringe needle mounting part 3 on the distal end side, ie, the upper side in FIG. 1, and a vial mounting part 5 on the proximal end side, ie, the lower side in FIG. The inside of the syringe vial adapter body 1 is cylindrical, and a vial 30 can be inserted into the syringe vial adapter body 1.

[0023] 1 has a cylindrical interior that allows liquid to pass through it, and has a connecting part 51 for connecting to the vial adapter body. The material of the injection needle 50 can be appropriately selected from the same materials as those normally used for syringes.

[0024] A tip end 7a of a conductive cylindrical part 7 is provided at the distal end of the injection needle attachment part 3, and an injection needle 50 can be tightly connected to the tip end 7a of the conductive cylindrical part 7.

[0025] As a means for tightly connecting the injection needle 50 to the tip end 7a of the conductive cylindrical part 7 in the injection needle attachment part 3 of the syringe vial adapter body 1, for example, a means for forming a screw thread and a screw groove at each joint part and fixing them by rotating them, or a means such as a locking mechanism for connecting them to each other by rotating them, can be used. Means for tightly connecting the injection needle 50 to the injection needle mounting part 3 of the syringe vial adapter body 1 are known, and any appropriate means can be used from among these known means.

[0026] Furthermore, a flange 9 is provided on the syringe vial adapter body 1, and by pressing this flange 9 with a finger, the vial 30 can be pushed into the syringe vial adapter body 1 with a thumb.

[0027] The vial mounting portion 5 of the syringe vial adapter body 1 can be fitted into the vial 30, and the vial mounting portion 5 can be installed so as to be movable relative to the vial 30 in the longitudinal direction of the syringe vial adapter body 1, i.e., in the vertical direction in Figure 1.

[0028] Next, the connecting tubular member 11 is preferably formed from the same material as the syringe vial adapter body 1. It is more preferable that it is made of a synthetic resin, as it is easy to process and has excellent impact resistance. The connecting tubular member 11 is a tubular body that penetrates from the distal end 11a to the proximal end 11b of the connecting tubular member 11. The distal end 11a of the connecting tubular member 11 is a connecting part for a conducting tubular part, and the proximal end 11b of the connecting tubular member 11 is a connecting part for a movable sealing member inside a vial.

[0029] The distal end 11a of the connecting tubular member 11 can be tightly connected to the conducting tubular portion 7 of the syringe vial adapter body 1. The proximal end 11 b of the connecting tubular member 11 can be tightly connected to the distal end 21 a of the inner movable sealing member 20 .

[0030] The connecting tubular member 11 has a flange portion 13, and the proximal end of this flange portion 13 is structured so as to be tightly connected to the distal end 21a of the vial internal movable sealing member 20.

[0031] Next, the vial inner movable sealing member 20 used in the present invention is inserted into the vial 30 and is movable within the vial 30 .

[0032] The vial internal movable sealing member 20 is made of an elastic material such as flexible synthetic rubber, silicone rubber, or elastomer resin. The vial internal movable sealing member 20 may be made entirely of an elastic material, or may be made of a combination of an elastic material and a material other than an elastic material. Examples of materials other than elastic materials include one or more of synthetic resin, metal, ceramic, and the like.

[0033] The vial inner movable sealing member 20 has protrusions 21, 23 and 25 formed at the distal end 21a, the central portion 21b and the proximal end 21c, respectively. In the case of the first embodiment of the present invention, three of these protrusions 21, 23 and 25 are formed, but the number of protrusions can be appropriately selected taking into consideration the sealing property and movability inside the vial.

[0034] Since the sides of the protrusions 21, 23 and 25 of the vial interior movable sealing member 20 move in close contact with the inner surface of the vial 30, the liquid 40 inside the vial 30 can be prevented from leaking out of the vial 30.

[0035] The vial internal movable sealing member 20 has a bottomed cylindrical opening 20d at the distal end 21a of the vial internal movable sealing member 20. By fitting the proximal end 11b of the connecting cylindrical member 11 into this bottomed cylindrical opening 20d, the vial internal movable sealing member 20 and the connecting cylindrical member 11 can be connected.

[0036] Although not shown in FIG. 1, vial-internal movable sealing member 20 has a penetration portion 27 that penetrates the entire vial-internal movable sealing member 20 relative to the longitudinal direction of vial adapter body 1 for syringe, i.e., the vertical direction in FIG. 1.

[0037] This penetration 27 opens when subjected to gas or liquid pressure and closes when this pressure is released. When there is no difference in gas or liquid pressure between the proximal end 21c and the distal end 21a of the vial-internal movable sealing member 20, the inner surface of the vial 30 and the side surface of the vial-internal movable sealing member 20 come into close contact with each other, and pressure is applied in the horizontal direction in Figure 1. This allows the penetration 27 to remain closed.

[0038] In the case of the first embodiment of the present invention, the penetration portion 27 of the vial internal movable sealing member 20 is a notch.

[0039] The vial 30 can be sealed with the movable sealing member 20 inside the vial, so that the liquid material 40 inside the vial 30 can be prevented from coming into contact with the outside air.

[0040] A liquid material 40 can be sealed inside the vial 30 . Examples of the liquid material 40 include liquid medicines, aqueous solutions of medicines dissolved in water, suspensions of medicines suspended in water, and paste-like substances such as medicines, cosmetics, repair agents, adhesives, etc.

[0041] 2 and 3 are schematic partial cross-sectional views for explaining the operation of the vial-equipped syringe 100 according to the first embodiment of the present invention.

[0042] As shown in FIG. 2, first, the syringe vial adapter body 1, the connecting tubular member 11, the vial inner movable sealing member 20, and the vial 30 are tightly connected. In the present invention, the meaning of "closely connected" is that even when the vial 30 is moved inside the syringe vial adapter body 1, the liquid material 40 does not leak out from anywhere other than the tip of the syringe needle. means. 2 and 3, the injection needle 50 is omitted for the sake of convenience.

[0043] The space between the distal end of the liquid 40 inside the vial 30 and the proximal end 20c of the vial inner movable sealing member 20 can be filled with nitrogen. The gas filled in the space of the vial 30 is not limited to nitrogen, and an inert gas such as helium or argon can also be used.

[0044] Next, the injection needle 50 is placed on the tip 7a of the conductive cylindrical part 7 at the distal end of the injection needle mounting part 3 at the upper end of FIG. 2 (see FIG. 1).

[0045] Inside the syringe vial adapter body 1, a conductive cylindrical part 7 that communicates with the injection needle mounting part 3 on the distal end side is provided. By tightly connecting the proximal end of this conductive cylindrical portion 7 and the distal end of the connecting cylindrical member 11, the syringe vial adapter body 1 and the connecting cylindrical member 11 can be communicated with each other.

[0046] Next, the vial 30 is inserted into the syringe vial adapter body 1 . Then, the inside of the vial 30 moves toward the proximal end of the vial 30, i.e., toward the bottom of the vial 30, while the sides of the protrusions 21, 23, and 25 of the vial internal movable sealing member 20 on the side of the vial internal movable sealing member 20 remain in close contact with the inner surface of the vial 30.

[0047] When the vial interior movable sealing member 20 moves inside the vial 30 , the liquid material 40 inside the vial 30 is pushed out from the inside of the vial 30 . This pressurization opens the penetration 27 that penetrates the entire movable sealing member 20 inside the vial, and the liquid material 40 passes through the inside of the movable sealing member 20 inside the vial, the inside of the connecting tubular member 11, the inside of the conductive tubular part 7 of the syringe vial adapter body 1, and the inside of the injection needle 50, and is discharged to the outside.

[0048] In the case of the vial-equipped syringe 100 of the invention according to the first embodiment of the present invention, the liquid material 40 inside the vial 30 can be transferred to the outside without being exposed to the outside air. This makes it possible to prevent the intrusion of foreign components contained in the outside air.

[0049] Furthermore, in the case of the vial-equipped syringe 100 of the invention according to embodiment 1 of the present invention, when the operation of pushing the vial 30 into the syringe vial adapter body 1 is stopped, the pressure applied to the penetration part 27 that penetrates the entire movable sealing member 20 inside the vial is released, and the open penetration part 27 closes. This makes it possible to stop the transfer of the liquid material 40 from the vial 30 to the outside. Therefore, even if one does not have special skills, anyone can easily discharge any desired amount of liquid material 40 from the vial-attached syringe 100 to the outside while visually checking the liquid material 40 safely.

[0050] The reverse operation to the above operation can also be performed. In the case of the vial-equipped syringe 100 of the invention according to the first embodiment of the present invention, an empty vial 30 is attached, and the vial 30 is first pushed into the syringe vial adapter body 1.

[0051] Next, while keeping the tip of the injection needle 50 immersed in the liquid 40, the vial 30 is pulled toward the proximal end, reducing the pressure inside the vial 30 and opening the penetration portion 27 that penetrates the entire movable sealing member 20 inside the vial. This allows the liquid material 40 to be easily stored inside the vial 30 from the injection needle 50 side. can.

[0052] The vial-equipped syringe 100 according to the first embodiment of the present invention has other advantages as well. Normally, when inserting the vial internal movable sealing member 20 into the vial 30 containing the liquid material 40, the internal gas is pressurized to the volume of the vial internal movable sealing member 20 being inserted, which makes it difficult to insert the vial internal movable sealing member 20 into the vial 30. However, in the case of the vial-internal movable sealing member 20 used in the present invention, there is a through-hole 27 that penetrates the entire vial-internal movable sealing member 20. Therefore, when the vial-internal movable sealing member 20 is inserted into a vial 30 containing a liquid material 40, even if the internal gas is pressurized to the volume of the inserted vial-internal movable sealing member 20, the pressurized through-hole 27 opens and the internal gas can escape to the outside. Therefore, the movable vial interior sealing member 20 can be easily inserted into the vial 30.

[0053] Additionally, in the case of the vial-equipped syringe 100 according to the first embodiment of the present invention, there is no need to pierce the movable sealing member 20 inside the vial with a syringe needle or the like, so the liquid material 40 can be transferred to the outside more easily.

[0054] Furthermore, in the case of the vial-equipped syringe 100 according to the first embodiment of the present invention, there is no need to bring a finger close to the injection needle, which is a safe and preferable design.

[0055] [Embodiment 2] FIG. 4 is a schematic diagram illustrating a vial internal movable sealing member 60 used in the second embodiment of the present invention. Embodiment 2 according to the present invention is a modified example of embodiment 1. In the case of embodiment 1, a notch is used as the penetration part 27 of the vial interior movable sealing member 20. In contrast to this, in the case of the second embodiment of the present invention, an opening slit that can be seen with the naked eye is formed as the through-hole 67 of the vial interior movable sealing member 60. The rest of the configuration is the same as in the case of the first embodiment.

[0056] Figure 4(a) is a plan view of the vial-internal movable sealing member 60, (b) is a cross-sectional view of the vial-internal movable sealing member 60 observed from the side, and (c) is a bottom view of the vial-internal movable sealing member 60 observed from the bottom.

[0057] The vial-internal movable sealing member 20 is made of an elastic material such as flexible synthetic rubber, silicone rubber, elastomer resin, etc. As a method for forming a slit as the penetration part 27 in the vial-internal movable sealing member 20, for example, a method of forming a slit in the vial-internal movable sealing member 20 with a blade or the like can be mentioned.

[0058] In contrast, the vial-internal movable sealing member 60 used in embodiment 2 is formed, for example, by heating an elastomer resin to make it fluid, and then extrusion molding using a mold. The overall shape of the vial-internal movable sealing member 60 and the opening slit serving as the through-hole 67 are simultaneously formed by extrusion molding.

[0059] The slit serving as the penetration portion 27 in the vial interior movable sealing member 20 used in embodiment 1 is naturally closed. In contrast, the opening slit serving as the penetration portion 67 in the vial interior movable sealing member 60 used in embodiment 2 can be seen with the naked eye. Here, the opening of the opening slit can be seen with the naked eye means that when light is applied to one end of the through-hole 67 of the vial interior movable sealing member 60, the light can be seen in its natural state from the other end. In other words, the opening slit penetrates the vial interior movable sealing member 60.

[0060] FIG. 5 is a schematic partial cross-sectional view illustrating a state in which a vial interior movable sealing member 60 used in the second embodiment of the present invention is inserted into a vial 30. As shown in FIG. As illustrated in FIG. 5, the horizontal diameter of the vial interior movable sealing member 60, based on a plane perpendicular to the longitudinal direction of the vial 30, is smaller than the diameter of the interior of the vial. Therefore, when the vial internal movable sealing member 60 is inserted into the vial 30, the opening slit serving as the penetration portion 67 of the vial internal movable sealing member 60 closes.

[0061] As in the case of the previous embodiment 1, the through-hole 67 opens in response to pressure on the vial-internal movable sealing member 60, and closes when the pressure on the vial-internal movable sealing member 60 is released. Therefore, it is possible to provide a vial-attached syringe 110 that has the same function as the vial-attached syringe 100 of embodiment 1. [Industrial Applicability]

[0062] By using the syringe with a vial according to the present invention, the liquid contained in the vial can be easily transferred to the outside of the syringe without coming into contact with the outside, and therefore the syringe with a vial according to the present invention can be widely used in, for example, medical and dental care fields and various development sites. [Explanation of symbols]

[0063] 1 syringe vial adapter body 3 Syringe needle installation part 5 Vial attachment section 7 Cylindrical part for inserting needle 7a Tip 9,13 Tsuba section 11 Connecting tubular member 11a, 21a distal end 11b, 21c proximal end 20,60 Movable sealing member inside vial 20d Bottomed cylindrical opening 21b Central part 21,23,25 Protrusion 27,67 Penetration 30 vials 40 Liquid 50 syringe needle 51 Vial adapter body connection part 100,110 Syringes with vials

Claims

1. The syringe vial adapter includes a syringe needle, a syringe vial adapter body, a connecting tubular member, a vial internal movable sealing member, and a vial; The inside of the syringe vial adapter body is cylindrical, the syringe vial adapter body has a syringe needle attachment portion on a distal end side and a vial attachment portion on a proximal end side, the syringe vial adapter body has a conductive cylindrical portion therein that communicates with the injection needle attachment portion on the distal end side, the connecting tubular member has a connecting portion for a conductive tubular member on a distal end side and a connecting portion for a vial internal movable sealing member on a proximal end side, the conductive cylindrical portion of the syringe vial adapter body is installed in the conductive cylindrical portion connecting portion on the distal end side of the connecting cylindrical member, the vial internal movable sealing member is installed at a vial internal movable sealing member connecting portion on the proximal end side of the connecting tubular member; The side surface of the vial interior movable sealing member is movably in close contact with the inner surface of the vial, the vial is movably installed in a vial mounting portion on the proximal end side of the syringe vial adapter body, The injection needle is installed in the injection needle mounting portion of the syringe vial adapter body, the syringe needle, the conductive cylindrical portion of the syringe vial adapter body, and the connecting cylindrical member are linearly and closely connected to each other with respect to the longitudinal direction of the syringe vial adapter body; the vial interior movable sealing member has a through-hole that penetrates the vial interior movable sealing member in the up-and-down direction with respect to the longitudinal direction of the syringe vial adapter body, A syringe with a vial, wherein the penetration portion opens in response to pressure on the vial's internal movable sealing member and closes when the pressure on the vial's internal movable sealing member is released.

2. 2. The syringe with a vial according to claim 1, wherein the through-hole is at least one of a notch and an opening slit.

3. 3. The syringe with a vial according to claim 2, wherein the injection needle, the syringe vial adapter body, the connecting tubular member, the vial internal movable sealing member, and the vial can be detachably and tightly connected to each other.

4. 4. The syringe with a vial according to claim 3, wherein the vial can be inserted into the syringe vial adapter body while the side surface of the vial inner movable sealing member remains in close contact with the inner surface of the vial.

5. inserting the vial into the syringe vial adapter body while maintaining a state in which the side surface of the vial interior movable sealing member is in close contact with the inner surface of the vial; a penetration portion of the vial internal movable sealing member that opens in response to pressure on the vial internal movable sealing member and closes when the pressure on the vial internal movable sealing member is released; A method for delivering a liquid material using the vial-equipped syringe according to any one of claims 1 to 4, comprising:

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