Composition for oral cavity

Abstract

To provide a composition for oral cavity which is not transformed into film even if dried, and sufficiently holds plasticity, does not inhibit cleanability inside an oral cavity, and is capable of suppressing drying of an oral cavity for a long period.SOLUTION: A composition for oral cavity according to the present invention contains a component A consisting of hydrophobic modified polyether-urethane and a component B consisting of polyacrylic acid and / or polyacrylic acid salt (note that a composition for oral cavity containing xanthan gum by 1.4 mass% or more is excluded). Further, it is preferable that the composition for oral cavity according to the present invention contain the component B consisting of sodium polyacrylate and water, the content of the component A be 0.25 mass% or more and 3 mass% or less, and the content of the component B be 0.01 mass% or more and 1 mass% or less.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an oral composition. [Background technology]

[0002] In recent years, the number of cases of dry mouth syndrome caused by a decrease in saliva secretion due to factors such as stress, aging, and side effects of medication has been increasing. When dry mouth syndrome develops, the mouth becomes dry and various unpleasant symptoms occur, and in severe cases, the tongue may crack or taste disorders may occur, making it difficult to taste food. Saliva also has antibacterial and self-cleaning properties, and plays an important role in protecting health, so when there is less saliva, bad breath becomes stronger and people become more susceptible to diseases such as tooth decay, periodontal disease, and stomatitis.

[0003] As a technique for improving dry mouth syndrome, for example, oral compositions that suppress dryness in the oral cavity have been proposed (see, for example, Patent Document 1). [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2012-153677 Summary of the Invention [Problem to be solved by the invention]

[0005] However, although the oral composition of Patent Document 1 can temporarily suppress dryness in the oral cavity, there is a problem that the preparation may turn into a film after a certain period of time, which reduces the ability to clean the oral cavity. Furthermore, once a film is formed, it is difficult to sufficiently suppress dryness in the oral cavity.

[0006] Therefore, the object of the present invention is to provide an oral composition that does not form a film even when dried, retains sufficient plasticity, does not hinder oral hygiene, and can suppress dryness in the oral cavity for a long period of time. [Means for solving the problem]

[0007] The oral composition of the present invention comprises component A consisting of a hydrophobically modified polyether urethane and component B consisting of polyacrylic acid and / or a polyacrylate (excluding oral compositions containing 1.4% by mass or more of xanthan gum).

[0008] The oral composition according to the present invention contains the component B consisting of sodium polyacrylate and water, The content of the component A is 0.25% by mass or more and 3% by mass or less, The content of the component B is preferably 0.01% by mass or more and 1% by mass or less.

[0009] Furthermore, in the oral composition of the present invention, when the content of component A is X [mass%] and the content of component B is Y [mass%], it is preferable that the relationship 4≦X / Y≦12 is satisfied. In addition, the oral composition according to the present invention preferably functions as an oral moisturizer. [Effects of the Invention]

[0010] According to the present invention, an oral composition can be provided that does not form a film even when dried, retains sufficient plasticity, does not hinder oral hygiene, and can suppress dryness in the oral cavity for a long period of time. DETAILED DESCRIPTION OF THE INVENTION

[0011] Preferred embodiments of the oral composition of the present invention will be described in detail below. The oral composition according to the present invention comprises a component A consisting of a hydrophobically modified polyether urethane and a component B consisting of polyacrylic acid and / or a polyacrylate salt.

[0012] The inclusion of such components A and B increases the retention of the oral composition in the oral cavity and can suppress dryness in the oral cavity. Furthermore, the inclusion of both components allows the oral composition to maintain its plasticity even when dried, does not impair its ability to clean the oral cavity, and can suppress dryness in the oral cavity for a long period of time. That is, the oral composition according to the present invention is a preparation that functions as an oral moisturizer.

[0013] The oral composition in this specification may be in any form, such as liquid, gel, or paste, but is preferably in gel form.

[0014] Each component will be described below. <Ingredient A> The oral composition of the present invention contains, as component A, a hydrophobically modified polyether urethane. The hydrophobically modified polyetherurethane is at least one associative polyurethane, which is a graft or sequential polymer containing at least two C6-C30 alkyl chains separated by a polyoxyethylenated hydrophilic chain. More specifically, the hydrophobically modified polyetherurethane may be, for example, a reaction product (copolymer) of polyethylene glycol, diisocyanate, and polyoxyethylene alkyl ether.

[0015] Generally, polyethylene glycol is a substance obtained by polymerizing ethylene oxide. Due to its unique properties of viscosity, non-irritation, water solubility, and lubricity, polyethylene glycol is a compound widely used in aqueous paints, paper coatings, adhesives, printing inks, and other surfactants. Due to its excellent solubility and compatibility with drugs, polyethylene glycol is an important raw material for the manufacture of pharmaceuticals and cosmetics in the bio-related fields of the pharmaceutical and cosmetic industries. In particular, polyethylene glycol, known as the Japanese Pharmacopoeia drug "Macrogol," is used as a solubilizer for various drugs, as an excipient, and as a cosmetic ingredient, depending on its molecular weight. Among the polyethylene glycols mentioned above, polyethylene glycols with a degree of polymerization of 200 to 2000 are preferred, and polyethylene glycols with a degree of polymerization of 200 to 300 are more preferred.

[0016] The diisocyanate is preferably an aliphatic diisocyanate, such as methylene diisocyanate, dimethylene diisocyanate, trimethylene diisocyanate, tetramethylene diisocyanate, pentamethylene diisocyanate, hexamethylene diisocyanate, dipropyl ether diisocyanate, 2,2-dimethylpentane diisocyanate, 3-methoxyhexane diisocyanate, octamethylene diisocyanate, 2,2,4-trimethylpentane diisocyanate, nonamethylene diisocyanate, decamethylene diisocyanate, 3-butoxyhexane diisocyanate, 1,4-butylene glycol dipropyl ether diisocyanate, thiodihexyl diisocyanate, metaxylylene diisocyanate, paraxylylene diisocyanate, and tetramethylxylylene diisocyanate.

[0017] Polyoxyethylene alkyl ether is HO-(CH2CH2O) nThe alkyl group is represented by -R, where n represents the average degree of polymerization, preferably 5 to 25, and more preferably 15 to 20. R represents an alkyl group. Examples of the alkyl group include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertiary butyl, pentyl, isopentyl, neopentyl, tertiary pentyl, hexyl, heptyl, octyl, 2-ethylhexyl, nonyl, decyl, undecyl, dodecyl, tridecyl, isotridecyl, myristyl, palmityl, stearyl, isostearyl, icosyl, docosyl, tetracosyl, triacontyl, 2-octyldodecyl, 2-dodecylhexadecyl, 2-tetradecyloctadecyl, and 2-decyltetradecyl.

[0018] The hydrophobically modified polyether urethane used in the oral composition of the present invention may be a commercially available product, such as Akzo's "Dapral T210" and "Dapral T212" brand, or Rohm and Haas's "Acrisol" brand.

[0019] The content of component A in the oral composition of the present invention is preferably 0.01% by mass to 10% by mass, more preferably 0.1% by mass to 5% by mass, and even more preferably 0.5% by mass to 3% by mass, which can more effectively prevent the oral composition from forming a film when dried.

[0020] <Component B> The oral composition of the present invention contains, as component B, polyacrylic acid and / or a polyacrylate. By including such a component, it is possible to maintain the gel state and prevent the gel from turning into a film due to drying.

[0021] The polyacrylic acid salt is preferably a monovalent salt, more preferably an alkali metal salt or an ammonium salt, further preferably an alkali metal salt such as a sodium salt or a potassium salt, and particularly preferably a sodium salt. The content of component B in the oral composition of the present invention is preferably 0.001% by mass to 3% by mass, more preferably 0.005% by mass to 2% by mass, and even more preferably 0.01% by mass to 1% by mass, which can more effectively prevent the oral composition from forming a film when dried.

[0022] Furthermore, when the content of component A is X [mass%] and the content of component B is Y [mass%], it is preferable to satisfy the relationship 0.0033≦X / Y≦10,000, more preferably 0.05≦X / Y≦1,000, even more preferably 0.5≦X / Y≦300, and particularly preferably 4≦X / Y≦12. By satisfying these relationships, the retention of the oral composition in the oral cavity can be further improved, and oral dryness can be more effectively suppressed. Furthermore, by setting the blending ratio of both components within the above range, the oral composition can more reliably maintain its plasticity even when dried, and oral dryness can be effectively suppressed for a long period of time. Furthermore, a decrease in oral hygiene can be more effectively suppressed.

[0023] <Other ingredients> The oral composition of the present invention may contain various ingredients depending on its dosage form, etc. For example, the oral composition of the present invention may contain abrasives, humectants, binders, foaming agents, sweeteners, preservatives, flavoring ingredients, medicinal ingredients, etc. Examples of abrasives include silica-based abrasives such as silica gel, precipitated silica, pyrogenic silica, hydrous silicic acid, anhydrous silicic acid, zeolite, aluminosilicate, and zirconosilicate, as well as crystalline cellulose, dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrate, calcium pyrophosphate, tribasic magnesium phosphate, tribasic calcium phosphate, aluminum hydroxide, alumina, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, zirconium silicate, and synthetic resin abrasives, and these can be used alone or in combination of two or more. The amount of the abrasive to be added is not particularly limited, but is preferably 3 to 60 mass %, and more preferably 10 to 45 mass %.

[0024] Examples of humectants include polyhydric alcohols such as glycerin, diglycerin, polyglycerin, 1,3-butylene glycol, polyethylene glycol, 1,2-pentanediol, 1,3-hexanediol, propylene glycol, dipropylene glycol, isopropylene glycol, polypropylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, maltitol, reduced starch syrup, lactitol, palatinit, erythritol, sorbitol, mannitol, xylitol, xylose, trehalose, glucose, lactose, mannose, maltose, fructose, inositol, pentaerythritol, maltotriose, starch hydrolyzed sugars, and starch hydrolyzed sugar reduced alcohols, and these may be used alone or in combination of two or more. The amount of the wetting agent to be added is not particularly limited, but is preferably 1 to 60% by mass, and more preferably 5 to 50% by mass.

[0025] Furthermore, a binder can be added to the extent that the function of component B is not impaired. Examples of binders include carrageenan (ι, λ, κ), alginic acid, sodium alginate, propylene glycol alginate, calcium-containing sodium alginate, potassium alginate, calcium alginate, ammonium alginate, and other alginates and their derivatives, xanthan gum, guar gum, agar, sodium carboxymethylcellulose, and hydroxyethyl cellulose, and one or more of these can be used in combination. The amount of binder blended is not particularly limited, but is preferably 0.1 to 5.0 mass %, and more preferably 0.5 to 3.0 mass %.

[0026] Examples of foaming agents include sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium alkyl sulfosuccinate, sodium coconut oil fatty acid monoglycerin sulfonate, sodium α-olefin sulfonate, N-acylamino acid salts such as N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, maltitol fatty acid esters, sucrose fatty acid esters, polyglycerin fatty acid esters, fatty acid diethanolamides, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, and polyoxyethylene fatty acid esters, and these can be used alone or in combination of two or more. The amount of the foaming agent to be added is not particularly limited, but is preferably 0.1 to 10.0% by mass, and more preferably 0.5 to 5.0% by mass.

[0027] Examples of sweeteners include saccharin sodium, aspartame, trehalose, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, and perillartine, and one or more of these can be used in combination. The amount of sweetener to be added is not particularly limited, but is preferably 0.005 to 5.0% by mass, and more preferably 0.01 to 3.0% by mass.

[0028] Examples of preservatives include parabens such as methylparaben, ethylparaben, propylparaben, and butylparaben, sodium benzoate, phenoxyethanol, and alkyldiaminoethylglycine hydrochloride, and these can be used alone or in combination of two or more. The amount of preservative to be added varies depending on the type of preservative, but is preferably 0.005 to 5.0% by mass, and more preferably 0.01 to 3.0% by mass.

[0029] The fragrance component may be one or more of 1-menthol, anethole, menthone, cineole, limonene, carvone, methyl salicylate, ethyl butyrate, eugenol, cinnamic aldehyde, trans-2-hexenal, etc. These components may be blended individually, or essential oils containing these may be used. In addition to the above fragrance components, fragrance components such as aliphatic alcohols and their esters, terpene hydrocarbons, phenol ethers, aldehydes, ketones, lactones, and essential oils may be blended within a range that does not impair the effects of the present invention. The blending amount of the above fragrances is generally in the range of 0.02 to 2% by mass.

[0030] The oral cavity composition of the present invention may further contain active ingredients other than those mentioned above. Examples of such active ingredients include lysozyme chloride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, polyethylene glycol, polyvinylpyrrolidone, zeolite, ascorbic acid, ascorbic acid salts, chlorhexidine salts, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, dequalinium chloride, bisabolol, tocopherol acetate, ε-aminocaproic acid, tranexamic acid, allantoin chlorohydroxyaluminum, allantoin, aluminum lactate, potassium nitrate, dihydrocholesterol, glycyrrhetinic acid, glycyrrhizinate salts, copper chlorophyllin salt, sodium chloride, guaiazulene sulfonate, dextranase, and pyridoxine hydrochloride, and one or more of these may be contained.

[0031] In addition to the above-mentioned ingredients, the composition may also contain, for example, coloring matter such as Blue No. 1, pigments such as titanium oxide, antioxidants such as dibutylhydroxytoluene, chelating agents such as edetate, and flavoring agents such as tea extract and dry distillation liquid of tea.

[0032] In addition to the above, the oral composition of the present invention may also contain herbal extracts. Examples of herbal extracts include chamomile extract, valerian extract, jujube extract, hop extract, lavender extract, linden extract, quince extract, goldenrod extract, kumazasa extract, kelp extract, clove extract, ginseng extract, salvia extract, soapberry extract, platycodon extract, rehmannia root extract, peony extract, hawthorn extract, angelica extract, tea extract, oak salicylate extract, bark extract, white birch extract, carrot extract, asafoetida extract, turmeric extract, and rosemary extract, and one or more of these may be used in combination. In addition to the above, the oral cavity composition of the present invention may contain an appropriate amount of a solvent such as water or ethanol.

[0033] The oral composition of the present invention can be produced in accordance with a conventional method, and the production method is not particularly limited. The obtained oral composition can be filled into an aluminum tube, a laminated tube, a glass-deposited tube, a plastic tube, a plastic bottle, an aerosol container, or the like for use.

[0034] Although the oral composition of the present invention has been described above, the present invention is not limited thereto. For example, in addition to the components described above, the oral composition of the present invention may contain components having any desired functions. [Example]

[0035] Next, specific examples of the present invention will be described. 1. Preparation of oral composition (Examples 1 to 7, Comparative Examples 1 to 4) The components shown in Tables 1 and 2 were prepared in the amounts shown in Table 1, and oral compositions were produced in a conventional manner. The units of contents in the table are % by mass. Furthermore, X / Y in the table is the content ratio of the hydrophobically modified polyether urethane of component A to the sodium polyacrylate (Na polyacrylate) of component B.

[0036] [Table 1]

[0037] 2. Evaluation Method [About stability] 100 g of the oral composition of each Example and Comparative Example was filled into a laminated tube, stored at 60°C for one week, and then returned to room temperature. The properties were visually evaluated according to the following three-level criteria. ◎: No change in properties. ○: Slight separation and / or softening is observed. ×: Separation and / or softening is observed.

[0038] [Lack of stickiness] A sample of each Example and Comparative Example oral composition was dispensed onto a piece of paper from a tube filled with the composition, and the sample was spread on the paper surface with a finger and evaluated according to the following three-level criteria. ◎: Non-sticky and smooth. 〇: Sticky ×: Sticky and stringy.

[0039] [Liquidity] A sample was taken out of the tube filled with the oral composition of each Example and Comparative Example, and evaluated according to the following three-level criteria. ◎: Moderate fluidity. ○: It is easy to drip or is too hard to remove from the storage container. ×: Liquid or too hard to be taken out of the storage container.

[0040] [Difficulty in filming] 1. A circle with a diameter of 3 cm was drawn in the center of a petri dish, and 0.3 g of a sample of the oral composition of each Example and Comparative Example was placed inside the circle and spread to the size of the drawn circle with a glass rod. The mixture was placed in a constant temperature incubator at 260°C and left to dry overnight (approximately 18 hours). 3. After removing from the incubator and returning to room temperature, the sample was spread with a finger and evaluated according to the following three-level criteria. ◎: Can be expanded by more than 1cm beyond a 3cm diameter circle. 〇: It can be expanded to an area of ​​1mm to 1cm larger than a 3cm diameter circle. ×: Solidified (turned into a film) and could not be spread at all (even 1 mm).

[0041] [About cleaning] 1. A circle with a diameter of 3 cm was drawn in the center of a petri dish, and 0.3 g of a sample of the oral composition of each Example and Comparative Example was placed inside the circle and spread to the size of the drawn circle with a glass rod. The mixture was placed in a constant temperature incubator at 260°C and left to dry overnight (approximately 18 hours). 3. After removing from the incubator and returning to room temperature, 0.3 g of the oral composition sample was placed on the dried oral composition and spread to cover it. 4. After 1 minute, the oral composition was wiped off with a sponge brush and evaluated according to the following three-level scale. ◎: The dried matter on the petri dish was completely removed. 〇: Almost all of the dried material on the petri dish can be removed. ×: No dried matter on the petri dish was removed These results are also shown in Table 1.

[0042] [Overall score] ◎: There are four or more ◎. 〇: Less than 4 ◎s and no ×s. ×: There is one or more ×.

[0043] As shown in Table 1, the oral compositions of the Examples suppress film formation upon drying, suppressing deterioration of oral hygiene and further suppressing oral dryness for a long period of time. Furthermore, the Examples also show excellent stability, stickiness, and fluidity. In contrast, the Comparative Examples did not produce satisfactory results.

Claims

1. An oral composition comprising component A consisting of a hydrophobically modified polyether urethane and component B consisting of polyacrylic acid and / or a polyacrylate salt (excluding oral compositions containing 1.4% by mass or more of xanthan gum).

2. The component B is composed of sodium polyacrylate, and water is included, The content of the component A is 0.25% by mass or more and 3% by mass or less, The oral composition according to claim 1 , wherein the content of component B is 0.01% by mass or more and 1% by mass or less.

3. 3. The oral composition according to claim 1, wherein the content of component A is X [mass %] and the content of component B is Y [mass %], the relationship of 4≦X / Y≦12 is satisfied.

4. 4. The oral composition according to claim 1, which functions as an oral moisturizer.

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