Oral composition

Abstract

To provide an oral composition capable of enhancing nail condition.SOLUTION: An oral composition comprises polyamines and piperines.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to oral compositions containing polyamines and piperines. [Background technology]

[0002] Many people pay attention to their nails, conscious of the impression they give others, as beautiful and healthy nails give a sense of cleanliness. However, many people have experienced problems with their nails and fingertips, including cracks, chips, and hangnails.

[0003] The causes of these problems include nutritional deficiencies, aging, and the effects of detergents and chemicals, and in young women, artificial nail adhesives and nail polish are among the causes. Patent Document 1 shows that mixing a tetrapeptide with nail keratin-increasing properties into artificial nail adhesives or nail polish can improve nail health. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Patent Publication No. 2011-87501 Summary of the Invention [Problem to be solved by the invention]

[0005] There is a need for a method to eliminate problems related to nails and fingertips. [Means for solving the problem]

[0006] The present invention includes, for example, the following aspects.

[0007] [1] An oral composition comprising polyamines and piperines. [2] The oral composition according to [1], which contains polyamines and piperines in a mass ratio of 1:10 to 1:50. [3] The oral composition according to [1], wherein the piperines are derived from at least one selected from the group consisting of long pepper extract and black pepper extract. [4] The oral composition according to [3], which contains polyamines, a long pepper extract, and a black pepper extract. [5] The oral composition according to [4], which contains a long pepper extract and a black pepper extract in a mass ratio of 1:0.5 to 1:3. [6] The oral composition according to [1], wherein the polyamines are derived from a soybean extract. [7] The oral composition according to [3], wherein the polyamines are derived from a soybean extract. [8] The oral composition according to [7], which contains soybean extract, long pepper extract, and black pepper extract. [9] The oral composition according to [1], further comprising one or more selected from biotin, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, and zinc compounds.

[10] The oral composition for improving the condition of nails according to any one of [1] to [9] above.

[11] A capsule containing the oral composition according to any one of [1] to [9] above.

[12] The oral composition according to any one of [1] to [9] above, which is in the form of granules, tablets or gummies. [Effects of the Invention]

[0008] According to the present invention, the condition of nails can be improved by ingesting the oral composition of the present invention. [Brief explanation of the drawings]

[0009] [Figure 1] This is a graph summarizing the results of a questionnaire about the condition of nails after four weeks of intake. DETAILED DESCRIPTION OF THE INVENTION

[0010] Hereinafter, embodiments of the present invention will be described in detail, but the present invention is not limited thereto.

[0011] The oral composition of the present invention contains polyamines and piperine. It may further contain one or more selected from biotin, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, and zinc compounds. Each component contained in the composition of the present invention will be described in detail below.

[0012] Polyamines, a general term for aliphatic hydrocarbons with two or more amino groups, are naturally occurring substances ubiquitously present in living organisms, and more than 20 types of polyamines have been discovered. Examples include 1,3-diaminopropane, putrescine, cadaverine, caldine, spermidine, homospermidine, aminopropylcadaverine, thermine, spermine, thermospermine, canavalmine, aminopentylnorspermidine, N,N-bis(aminopropyl)cadaverine, homospermine, caldopentamine, homocaldopentamine, caldohexamine, and homocaldohexamine. In the present invention, polyamines preferably contain putrescine, spermidine, and spermine. The origin and production method of polyamines are not particularly limited. Polyamines may be synthetic or extracted from plants containing polyamines. Examples of plants containing polyamines include soybeans, rice, and wheat. When polyamines are obtained by extraction from plants, the extraction solvent is not particularly limited, and examples thereof include water, alcohols (e.g., methanol, ethanol, n-propanol, n-butanol, etc.), acetone, etc. In one embodiment, polyamines may be extracted from soybeans. Commercially available polyamines and soybean extracts can also be used.

[0013] In the oral composition of the present invention, the amount of polyamines to be added may be appropriately determined depending on the form of the food, etc., and may be, for example, 0.001% by weight to 10% by weight, preferably 0.005% by weight to 1% by weight, and more preferably 0.01% by weight to 0.5% by weight.

[0014] The daily intake of polyamines is usually 0.001 mg or more, preferably 0.01 mg or more, more preferably 0.05 mg or more, and usually 10 mg or less, preferably 5 mg or less, more preferably 3 mg or less.

[0015] Piperines are substances classified as piperidine ring-containing alkaloids, including (2E,4E,8E)-N-[9-(3,4-methylenedeoxyphenyl)-2,4,8-nonatrienoyl]piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoyl]piperidine, and 1-[(2Z,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoyl]piperidine. In the present invention, the origin and production method of piperines are not particularly limited. Piperines may be synthetic or extracted from plants containing piperine. Examples of plants containing piperine include plants of the Piperaceae family, such as black pepper (Piper nigrum) and long pepper (Piper longum). When obtained by extraction from plants, the extraction solvent is not particularly limited, but examples include water, alcohol (e.g., methanol, ethanol, n-propanol, n-butanol, etc.), acetone, etc., and preferably hot water or ethanol. In one embodiment, piperines may be extracted from black pepper fruits or long pepper spikes. Commercially available piperines, black pepper extracts, and long pepper extracts can also be used. It is also preferable to use a powdered long pepper extract together with dextrin.

[0016] In the oral composition of the present invention, the amount of piperine may be appropriately determined depending on the food form, etc., but may be, for example, 0.01% to 10% by weight, preferably 0.05% to 5% by weight, and more preferably 0.1% to 3% by weight. When black pepper extract is added, the amount may be appropriately determined depending on the food form, etc., but may be, for example, 0.01% to 10% by weight, preferably 0.05% to 5% by weight, and more preferably 0.1% to 3% by weight. When long pepper extract is added, the amount may be appropriately determined depending on the food form, etc., but may be, for example, 0.01% to 10% by weight, preferably 0.05% to 5% by weight, and more preferably 0.1% to 3% by weight.

[0017] In addition, the daily intake of piperines is usually 0.01 mg or more, preferably 0.1 mg or more, more preferably 0.5 mg or more, and usually 50 mg or less, preferably 30 mg or less, more preferably 10 mg or less. The daily intake of black pepper extract is usually 0.01 mg or more, preferably 0.1 mg or more, more preferably 0.5 mg or more, and usually 50 mg or less, preferably 30 mg or less, more preferably 10 mg or less. The daily intake of long pepper extract is usually 0.01 mg or more, preferably 0.1 mg or more, more preferably 0.5 mg or more, and usually 50 mg or less, preferably 30 mg or less, more preferably 10 mg or less.

[0018] In the oral composition of the present invention, the ratio of polyamines to piperines is 1:1 to 1:100, preferably 1:5 to 1:70, and more preferably 1:10 to 1:50.

[0019] In the oral composition of the present invention, the mass ratio of the black pepper extract to the long pepper extract is 1:0.1 to 1:10, preferably 1:0.3 to 1:7, and more preferably 1:0.5 to 1:3.

[0020] Biotins refer to biotin, its derivatives, and salts thereof. The types of biotins used in the present invention are not particularly limited, as long as they can be incorporated into foods. Salts of biotin and its derivatives include, for example, alkaline earth metal salts such as calcium salts; and ammonium salts. These biotins may be used alone or in combination of two or more.

[0021] Vitamin A refers to vitamin A1 (retinol, retinal, retinoic acid), vitamin A2 (3-dehydroretinol, 3-dehydroretinal, 3-dehydroretinoic acid), and derivatives thereof. The type of vitamin A used in the present invention is not particularly limited, as long as it can be incorporated into foods. These vitamin A compounds may be used alone or in combination of two or more.

[0022] Vitamin B1 refers to vitamin B1 (thiamine), its derivatives, and their salts. The type of vitamin B1 used in the present invention is not particularly limited, as long as it can be incorporated into foods. In addition, salts of vitamin B1 and its derivatives include inorganic acid salts such as hydrochloride, nitrate, and sulfate. These vitamin B1 compounds may be used alone or in combination of two or more.

[0023] Vitamin B2 refers to vitamin B2 (riboflavin), its derivatives, and salts thereof. The type of vitamin B2 used in the present invention is not particularly limited, as long as it can be incorporated into foods. In addition, salts of vitamin B2 and its derivatives include inorganic acid salts such as hydrochloride and nitrate. These vitamin B2s may be used alone or in combination of two or more.

[0024] Vitamin B6 refers to vitamin B6 (pyridoxine), its derivatives, and salts thereof. The type of vitamin B6 used in the present invention is not particularly limited, as long as it can be incorporated into foods. In addition, salts of vitamin B6 and its derivatives include, for example, inorganic acid salts such as hydrochloride. These vitamin B6 compounds may be used alone or in combination of two or more.

[0025] Vitamin B12 compounds refer to vitamin B12 (cyanocobalamin), its derivatives, and salts thereof. The type of vitamin B12 compounds used in the present invention is not particularly limited, as long as they can be incorporated into foods. In addition, salts of vitamin B12 and its derivatives include, for example, inorganic acid salts such as hydrochloride and nitrate. These vitamin B12 compounds may be used alone or in combination of two or more.

[0026] Vitamin C refers to vitamin C (ascorbic acid), its derivatives, and their salts. The type of vitamin C used in the present invention is not particularly limited, as long as it can be incorporated into foods. In addition, examples of salts of vitamin C and its derivatives include alkali metal salts such as sodium salt and potassium salt. These vitamin C compounds may be used alone or in combination of two or more.

[0027] Vitamin Ds refer to vitamin D2 (ergocalciferol), vitamin D3 (cholecalciferol), and their derivatives. The types of vitamin Ds used in the present invention are not particularly limited, as long as they can be incorporated into foods. These vitamin Ds may be used alone or in combination of two or more.

[0028] Vitamin E refers to vitamin E (tocopherol, tocotrienol) and its derivatives. The type of vitamin E used in the present invention is not particularly limited, as long as it can be incorporated into foods. Examples of vitamin E derivatives include tocopherol organic acid esters such as tocopherol acetate, tocopherol succinate, tocopherol linoleate, tocopherol linolenate, tocopherol nicotinate, and tocopherol (linoleate / oleate). These vitamin E compounds may be used alone or in combination of two or more.

[0029] The zinc compound refers to zinc salts or zinc yeasts enriched with zinc by adding zinc salts to yeast cultures to allow the yeast to incorporate zinc. The type of zinc compound used in the present invention is not particularly limited, as long as it can be incorporated into foods. Examples of zinc salts include zinc chloride, zinc sulfate, zinc gluconate, zinc lactate, and zinc citrate. These zinc compounds may be used alone or in combination of two or more.

[0030] The oral composition of the present invention may contain other nutritional components or pharmacological components in addition to the above-mentioned components. Such nutritional components and pharmacological components are not particularly limited as long as they are usable in foods and oral pharmaceuticals, and examples thereof include amino acids, minerals, carbohydrates, animal fats and oils, vegetable fats and oils, fatty acids, flavorings, seasonings, plant extracts, etc. These components may be used alone or in combination of two or more. The content of these components is appropriately determined depending on the type of components used and the intended use of the oral composition.

[0031] Furthermore, in order to prepare the oral composition of the present invention into a desired formulation, it may contain, as necessary, bases, additives, etc. in addition to the above-mentioned components. Such bases and additives are not particularly limited as long as they are usable in foods and pharmaceuticals, and examples thereof include water, lower alcohols, higher alcohols, water-soluble polymers, surfactants, polyhydric alcohols, pH adjusters, buffers, antioxidants, preservatives, thickeners, chelating agents, etc. These may be used alone or in combination of two or more. The content of these bases and additives is appropriately determined depending on the types of components used and the intended use of the oral composition.

[0032] The form of the oral composition of the present invention is not particularly limited as long as it can be orally ingested or administered, and may be any of solid, semi-solid, or liquid, and may be appropriately selected depending on the type and use of the oral composition.

[0033] The uses of the oral composition of the present invention are not particularly limited as long as it can be orally ingested or administered, and specific examples include foods and beverages and oral pharmaceuticals. Examples of foods and beverages include general foods and beverages, as well as foods for specified health uses, nutritional supplements, functional foods, nutritionally functional foods, and foods for patients. When made into beverages, they can be made into nutritional drinks, soft drinks, carbonated drinks, lactic acid drinks, and the like, and when made into foods, they can be made into luxury items such as gummies and candies.

[0034] When the oral composition of the present invention is formulated, the dosage form is not particularly limited, and examples thereof include capsules (soft capsules, hard capsules), tablets, granules, powders, jellies, etc. Among these, capsules, tablets, granules, and powders are preferred, capsules are more preferred, and soft capsules are particularly preferred. When the oral composition of the present invention is formulated as a capsule, the content ratio of each component described above means the content ratio in the contents of the capsule.

[0035] The base material used in soft capsules is not particularly limited, but examples thereof include vegetable oils and fats, animal oils and fats, etc.

[0036] Examples of vegetable oils include, but are not limited to, rice germ oil, olive oil, linseed oil, wheat germ oil, safflower oil, perilla oil, soybean oil, camellia oil, corn oil, peppermint oil, castor oil, cottonseed oil, coconut oil, peanut oil, and refined oils derived from vegetable oils.

[0037] The animal fats and oils are not particularly limited, but examples thereof include fish oil, egg yolk oil, beef tallow, lard, refined oils derived from animal fats and oils, and the like.

[0038] Refined oils derived from animal fats include docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). DHA is found in large amounts in tuna, monkfish, mackerel, saury, yellowtail, horse mackerel, eel, salmon, sardines, etc. EPA is found in large amounts in tuna, mackerel, saury, yellowtail, horse mackerel, sardines, red sea bream, flounder, etc.

[0039] In one embodiment, the oil preferably includes vegetable oil. Compared to animal oil, vegetable oil has almost no taste or odor, and therefore, soft capsules that are easy to ingest can be obtained. In another embodiment, the oil preferably includes at least one of rice germ oil, linseed oil, and safflower oil, and more preferably includes rice germ oil.

[0040] The emulsifier used in soft capsules is not particularly limited, but examples thereof include lecithin, glycerin fatty acid ester, sucrose fatty acid ester, saponin, wax, and the like.

[0041] Lecithin is a glycerophospholipid containing glycerin, choline, and fatty acids. Examples of the fatty acids include palmitic acid, stearic acid, oleic acid, linoleic acid, and α-linolenic acid. Lecithin is usually a mixture of glycerophospholipids. Lecithin can be obtained by extraction from chicken eggs, soybeans, rapeseed, beef, etc. Among these, soybean lecithin and egg yolk lecithin are preferred, and soybean lecithin is more preferred. The composition of the glycerophospholipids contained in lecithin can be appropriately adjusted, for example, by selecting raw materials, extraction methods, purification methods, etc.

[0042] Glycerin fatty acid esters have a structure in which a fatty acid is ester-bonded to one or two of the three hydroxyl groups of glycerin. Examples of glycerin fatty acid esters include, but are not limited to, acetate monoglyceride, lactate monoglyceride, citrate monoglyceride, diacetyltartarate monoglyceride, succinate monoglyceride, polyglycerin fatty acid ester, and polyglycerin condensed linosyl acid ester.

[0043] Sucrose fatty acid esters have a structure in which sucrose is esterified with a fatty acid to 1 to 8, preferably 1 to 3, of the eight hydroxyl groups of sucrose. Examples of sucrose fatty acid esters include, but are not limited to, sucrose stearate, sucrose palmitate, sucrose myristate, sucrose oleate, sucrose laurate, sucrose behenate, sucrose erucate, and sucrose mixed fatty acid (oleate / palmitate / stearate) ester.

[0044] Saponins are glycosides containing sapogenin (aglycone) with a triterpene or steroid skeleton and a sugar chain. There are a variety of molecular species depending on the aglycone structure, sugar chain structure, and whether or not the sugar chain has been modified (acetylated, etc.) with a hydroxyl group. Specific examples of saponins include soybean saponin, onjisaponin, platycodon saponin, senegasaponin, and ginsenoside.

[0045] Wax, also called wax, is an ester of fatty acids and alcohol obtained from plants and animals. Specific examples of wax include beeswax, white beeswax, carnauba wax, rice bran wax, and lanolin.

[0046] The gelling agent used in soft capsules is not particularly limited, but examples thereof include gelatin, casein, polysaccharides, starches, and the like.

[0047] Examples of gelatin include beef gelatin, pork gelatin, chicken gelatin, fish gelatin, and gelatin derivatives. In this case, examples of the gelatin derivatives include cross-linked gelatin cross-linked with organic compounds (methacrylic acid, acrylic acid, (poly)lactic acid, methacrylamide, etc.), gelatin hydrolysates, etc.

[0048] Examples of the polysaccharides include carrageenan, agar, sodium alginate, pullulan, glucomannan, gum arabic, welan gum, xanthan gum, gellan gum, tragacanth gum, locust bean gum, pectin, polydextrose, dextrin, maltodextrin, cyclodextrin, indigestible dextrin, guar gum, psyllium seed gum, hydroxypropyl cellulose, hydroxypropylmethylcellulose, methylcellulose, carboxymethylcellulose, and chitosan.

[0049] Starches include, but are not limited to, natural starches and modified starches.

[0050] The natural starch is not particularly limited, but examples thereof include potato starch, tapioca starch, glutinous corn starch, glutinous rice starch, sago starch, sweet potato starch, mung bean starch, and wheat starch.

[0051] "Improving the condition of the nails" in the present invention includes the concept of making the nails and / or the skin around the nails healthy, improving the condition compared to the current state, etc. Specific examples include, but are not limited to, improving vertical lines on the nails, improving nail hardness, improving cracks and chips in the nails, improving nail luster, improving nail color, improving hangnails, etc.

[0052] The "oral composition for improving nail condition" of the present invention is not particularly limited as long as it can be distinguished from other products in that it is used to improve nail condition. For example, the scope of the present invention includes a product that displays, by words, photographs, pictures, etc., on the body, packaging, instructions, or promotional materials of the product according to the present invention, that the product has the function of keeping nails and / or the skin around the nails healthy.

[0053] The oral composition of the present invention can be administered or taken once or in divided doses (for example, 2 to 3 times) per day.

[0054] The oral composition of the present invention can be administered or taken over an extended period of time, for example, two or more days, three or more days, five or more days, one or more weeks, two or more weeks, three or more weeks, one or more months, two or more months, three or more months, four or more months, five or more months, six or more months, seven or more months, eight or more months, or more. [Example]

[0055] The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples.

[0056] An ingestion test was conducted on the oral composition of the present invention. The composition of the oral composition used is as shown in Table 1, and it was ingested in the form of a soft capsule. The soft capsule had a capsule shell mainly composed of gelatin and glycerin, and was produced by a punching method using a rotary mold capsule filling machine.

[0057] [Table 1]

[0058] In Table 1, the sources and raw material names of the soybean extract powder, long pepper extract powder, and black pepper extract used are as follows: Soy extract powder: "Soypolia (contains soy extract, citric acid, and approximately 0.15% polyamines)" (manufactured by Combi, Inc.) Long Pepper Extract Powder: "Tie2 Long Pepper Extract Powder MF (contains long pepper extract, dextrin, and approximately 800 ppm of piperine)" (Maruzen Pharmaceutical Co., Ltd.) Black pepper extract: "Bioperine (piperine content approximately 100%)" (Sabinsa Japan Corporation)

[0059] How to take Thirteen male and female subjects (aged 23 to 52 years) took three soft capsules containing the oral composition shown in Table 1 daily for four weeks.

[0060] "Evaluation of the experience" 1. Evaluation Method After 4 weeks of intake, 13 subjects were asked to complete a questionnaire to rate their physical condition on a 3-point scale (improved, no change, worsened) in terms of "condition of vertical lines on nails," "condition of nail hardness," "condition of cracks and chips on nails," "condition of nail shine," "condition of nail color," and "condition of hangnails" compared to before intake. The results are shown in Figure 1.

[0061] 2.Results Of the 13 people who took the supplement, 7 reported that the condition of the vertical lines on their nails had improved. Of the 13 people who took the supplement, 9 reported that their "nail hardness" had improved. Of the 13 people who took the supplement, 6 reported that their "cracked and chipped nails" had improved. Of the 13 people who took the supplement, 7 reported that the "luster condition of their nails" had improved. Of the 13 people who took the supplement, 10 reported that the color of their nails had improved. Of the 13 people who took the product, 6 reported that their hangnail condition had improved. All 13 people who took the product reported improvement in one or more of the following areas: "Vertical lines on the nails," "Hardness of the nails," "Cracks and chips on the nails," "Shine on the nails," "Nail color," and "Hangnails."

[0062] From the above, it was confirmed that taking a composition containing polyamines and piperines has the effect of improving the condition of nails.

Claims

1. An oral composition comprising polyamines and piperines.

2. 2. The oral composition according to claim 1, wherein the polyamines and piperines are contained in a mass ratio of 1:10 to 1:

50.

3. 2. The oral composition of claim 1, wherein the piperines are derived from at least one selected from the group consisting of long pepper extract and black pepper extract.

4. 4. The oral composition according to claim 3, comprising polyamines, a long pepper extract and a black pepper extract.

5. 5. The oral composition according to claim 4, wherein the long pepper extract and the black pepper extract are contained in a mass ratio of 1:0.5 to 1:

3.

6. 10. The oral composition of claim 1, wherein the polyamines are derived from a soybean extract.

7. 4. The oral composition of claim 3, wherein the polyamines are derived from a soybean extract.

8. 8. The oral composition of claim 7, comprising soybean extract, long pepper extract and black pepper extract.

9. The oral composition according to claim 1, further comprising one or more selected from biotins, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, and zinc compounds.

10. The oral composition for improving nail condition according to any one of claims 1 to 9.

11. A capsule containing the oral composition according to any one of claims 1 to 9 as its content.

12. The oral composition according to any one of claims 1 to 9, which is in the form of granules, tablets or gummies.

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