Skin external preparation
By combining hydrolyzed gardenia extract with bilberry leaf and/or rice bran extract, the fading issue is addressed, enhancing skin elasticity and clarity while allowing for a wider range of formulations with higher water content.
Patent Information
- Application Number
- JP2024087559
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2024-05-30
- Publication Date
- 2025-12-11
AI Technical Summary
Natural pigments like hydrolyzed gardenia extract suffer from poor light and heat resistance, leading to fading and limiting their application in a wide range of formulations due to restrictions on water content and amount added, which affects skin care benefits.
Incorporating bilberry leaf extract and/or rice bran extract with hydrolyzed gardenia extract in topical skin preparations to inhibit discoloration, allowing for a water content of 10% or more without impairing skin appearance or effects, and enabling a broader range of formulations.
The combination enhances skin elasticity, improves skin clarity, and maintains transparency over time while preventing fading, with no restrictions on the amount added or application, thus expanding formulation possibilities.
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Abstract
Description
[Technical Field]
[0001] The present invention relates to an external preparation for skin. [Background technology]
[0002] Natural pigments derived from animals, plants, and microorganisms not only impart color to formulations but also can change the color of skin and hair to a desired shade, and thus have been used in many topical skin preparations. Some natural pigments not only have skin color-imparting effects, but also have skin care effects, such as moisturizing the skin. One example is hydrolyzed gardenia extract obtained from gardenia. It has been reported that when combined with a moisturizer, it is effective in moisturizing, improving rough skin, and preventing skin aging, and that when combined with a whitening agent, it enhances the whitening effect. (Patent Documents 1 and 2)
[0003] On the other hand, many natural pigments, including hydrolyzed gardenia extract, have poor light and heat resistance and tend to fade over time, resulting in reduced skin benefits. Therefore, when incorporating natural pigments into topical skin preparations, measures to ensure quality are necessary. Measures to ensure quality include, for example, the use of an anti-fading agent for gardenia blue pigment and / or safflower yellow pigment containing chlorogenic acids as active ingredients (Patent Document 3), and containing 20% by weight or more of a natural pigment, a hydrophilic surfactant, and at least one polyhydric alcohol having at least three or more hydroxyl groups in the molecule, with a substantial water content of 10% by weight or less (Patent Document 4). [Prior art documents] [Patent documents]
[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2000-119155 [Patent Document 2] Japanese Patent Application Laid-Open No. 2000-119156 [Patent Document 3] Japanese Patent Application Publication No. 5-032909 [Patent Document 4] Japanese Patent Application Laid-Open No. 2007-077112 Summary of the Invention [Problem to be solved by the invention]
[0005] However, the above-mentioned measures have limitations on the amount added and applications due to the unique color or fragrance caused by the anti-fading agent, and the range of formulations is limited if the water content is 10% by mass or less, making it difficult to apply to a wide range of formulations. For these reasons, a new method for preventing or suppressing the fading of hydrolyzed gardenia extract that is not limited by the amount added or applications and can be applied to a wide range of formulations is needed.
[0006] The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an external skin preparation containing hydrolyzed gardenia extract that can be applied to a wide range of formulations while preventing discoloration of the hydrolyzed gardenia extract. [Means for solving the problem]
[0007] As a result of intensive research to solve the above problems, the present inventors discovered that the incorporation of bilberry leaf extract and / or rice bran extract can inhibit the discoloration of hydrolyzed gardenia extract. Therefore, by combining hydrolyzed gardenia extract, bilberry leaf extract, and / or rice bran extract, they discovered an external skin preparation that can have a water content of 10% by mass or more without impairing the appearance or effects on the skin of the external skin preparation over time, without imposing restrictions on the amount added or application, and completed the present invention.
[0008] The external skin preparation according to the present invention contains the following component (A) and component (B): (A) Hydrolyzed Gardenia Extract (B) Bilberry leaf extract and / or rice bran extract
[0009] With this constitution, the external skin preparation of the present invention can be applied to a wide range of preparations while preventing discoloration of the hydrolyzed gardenia extract.
[0010] The topical skin preparation according to the present invention may have an amount of component (A) of 0.0001 to 3% by mass relative to the total mass of the topical skin preparation, an amount of component (B) of 0.00001 to 3% by mass relative to the total mass of the topical skin preparation, and a ratio (A / B) of the amount of component (A) to the amount of component (B) of 0.05 to 25.
[0011] The external preparation for skin according to the present invention has the following properties: [Effects of the Invention]
[0012] According to the present invention, it is possible to provide an external skin preparation which suppresses dullness of the skin, contributes to improving transparency, increases skin elasticity, and has an excellent feel when used. DETAILED DESCRIPTION OF THE INVENTION
[0013] The following describes in detail embodiments of the present invention, but the present invention is not limited to the following embodiments. The present invention is not limited to the configurations described below, and various modifications are possible within the scope of the claims. Embodiments and examples obtained by appropriately combining the technical means disclosed in different embodiments and examples are also included in the technical scope of the present invention. Furthermore, in this specification, unless otherwise specified, "A to B" representing a numerical range means "greater than or equal to A and less than or equal to B."
[0014] The topical skin preparation according to this embodiment contains (A) hydrolyzed gardenia extract and (B) bilberry leaf extract and / or rice bran extract.
[0015] <(A) Hydrolyzed Gardenia Extract> The component (A) used in the topical skin preparation according to this embodiment is a hydrolyzed gardenia extract. The hydrolyzed gardenia extract is obtained by hydrolyzing an extract obtained from the fruit of gardenia, a plant of the Rubiaceae family. Methods for hydrolysis include, but are not limited to, the use of acids and enzymes.
[0016] These ingredients are available as commercially available cosmetic ingredients, such as "Gardenia Green Color PG1" and "Gardenia Blue Color 1250P" (both manufactured by Glico Nutrition Foods Co., Ltd.) and "Gardenia Blue" (manufactured by Koei Kogyo Co., Ltd.).
[0017] The inclusion of hydrolyzed gardenia extract as component (A) in the topical skin preparation according to this embodiment reduces skin dullness, contributes to improved skin clarity, and enhances skin elasticity. The amount of component (A) is not particularly limited, but is preferably 0.0001% by mass or more and 3% by mass or less of the total mass of the topical skin preparation. A content of component (A) of 0.0001% by mass or more sufficiently reduces dullness and achieves a sufficient effect of improving skin clarity. On the other hand, a content of component (A) of 3% by mass or less reduces stickiness and improves the complexion of the skin. From the viewpoint of usability, the amount of component (A) is more preferably 0.0005% by mass or more and 1% by mass or less, and even more preferably 0.001% by mass or more and 0.5% by mass or less.
[0018] Hydrolyzed gardenia extract alone can improve skin elasticity, but as will be explained later (B By adding hydrolyzed gardenia extract to the ingredients, the effect of improving skin elasticity is synergistically enhanced and the effect is long-lasting.
[0019] <(B) Bilberry leaf extract and / or rice bran extract> The component (B) used in the topical skin preparation according to this embodiment is bilberry leaf extract and / or rice bran extract. Bilberry leaf extract is an extract obtained from the leaves of Vaccinium maritimus, a member of the Ericaceae family.
[0020] Bilberry leaf extract is available as a cosmetic ingredient in the market, including "Cureberry," "Ecofarm Bilberry Leaf E," and "Ecofarm Bilberry Leaf G" (all manufactured by Ichimaru Pharcos Co., Ltd.).
[0021] Rice bran extract is an extract obtained from rice bran. Extraction methods include, but are not limited to, methods using water, ethanol, butylene glycol, etc.
[0022] Rice bran extract is available commercially as a cosmetic ingredient. Examples of commercially available products include "Rice Bran Extract" (Koei Kogyo Co., Ltd.), "Purple Brown Rice Bran Extract" and "Rice Bran Extract BG" (both from Maruzen Pharmaceutical Co., Ltd.), and "Tsuyahime Rice Bran Extract" (NOF Corporation).
[0023] The inclusion of bilberry leaf extract and / or rice bran extract as component (B) in the topical skin preparation according to this embodiment can inhibit discoloration of the hydrolyzed gardenia extract. This is presumably because the polyphenols contained in the bilberry leaf extract and / or rice bran extract absorb and convert light and heat, thereby inhibiting the effects of these on the hydrolyzed gardenia extract.
[0024] The amount of component (B) contained in the topical skin preparation according to this embodiment is preferably 0.00001% by mass or more and 3% by mass or less of the total mass of the topical skin preparation. A content of component (B) of 0.00001% by mass or more provides sufficient anti-fading effect of hydrolyzed gardenia extract, while a content of component (B) of 3% by mass or less can suppress stickiness and is not affected by the unpleasant odor derived from bilberry leaf extract and / or rice bran extract over time. From the viewpoint of usability, the amount of component (B) is more preferably 0.00005% by mass or more and 1% by mass or less, and even more preferably 0.0001% by mass or more and 0.5% by mass or less.
[0025] Hydrolyzed gardenia extract alone can improve skin elasticity, but adding ingredient (B) synergistically enhances the skin elasticity-enhancing effect and provides excellent lasting effects.
[0026] Furthermore, in the topical skin preparation according to this embodiment, the ratio (A / B) of the amount of component (A) to the amount of component (B) is preferably 0.05 to 25, more preferably 0.1 to 20. When this ratio is 0.05 or more, the effect of component (B) in inhibiting discoloration relative to component (A) can be sufficiently exhibited, and the effect of maintaining skin transparency over time can be maintained. When this ratio is 25 or less, the color derived from component (A) or the color of the preparation is not affected by the color derived from (B).
[0027] The topical skin preparation according to this embodiment contains bilberry leaf extract and / or rice bran extract, which are component (B), to suppress discoloration of hydrolyzed gardenia extract, which is component (A). Therefore, there is no effect of the scent of bilberry leaf extract and / or rice bran extract, and there are no restrictions on the amount added or application. Furthermore, there is no restriction on the water content of the topical skin preparation. Therefore, the topical skin preparation according to this embodiment can be applied to a wide range of formulations.
[0028] <Other ingredients> In addition to the above-mentioned components, the topical skin preparation according to this embodiment may contain other components, such as anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, oils, polymeric compounds, thickeners, powders (dyes, resins, pigments), preservatives, fragrances, moisturizers, physiologically active ingredients, mineral salts, solvents, antioxidants, chelating agents, pearlizing agents, neutralizing agents, pH adjusters, plant extracts, enzymes, and the like, as appropriate, provided that the purpose of the present invention is not impaired.
[0029] Furthermore, the topical skin preparation of the present invention can be appropriately blended with physiologically active ingredients within the scope of the present invention. Physiologically active substances are substances that impart some physiological activity to the skin when applied to the skin, and examples thereof include anti-inflammatory agents, anti-aging agents, UV protection agents, astringents, antioxidants, blood circulation promoters, antibacterial agents, disinfectants, drying agents, cooling agents, warming agents, vitamins, amino acids, wound healing promoters, irritation soothing agents, analgesics, and cell activators.
[0030] The topical skin preparation according to this embodiment can be manufactured according to conventional methods. The topical skin preparation according to this embodiment can be used, for example, as a lotion, emulsion, cream, gel, serum, sheet mask, makeup, body lotion, body gel, body cream, or makeup base. The dosage form can also be selected arbitrarily depending on the purpose. Examples include liquid, cream, gel, emulsion, sheet, stick, and aerosol forms. The topical skin preparation according to this embodiment is not limited to general topical preparations, but also includes quasi-drugs, designated quasi-drugs, and topical pharmaceuticals. [Example]
[0031] The present invention will now be described in detail with reference to examples, but is not limited thereto. Prior to the examples, the test and evaluation methods employed in each example will be described.
[0032] 1. Skin clarity evaluation test The forearms of 10 evaluation panelists were washed with lukewarm water and then allowed to acclimate for 20 minutes in an environment of 25°C and 50% relative humidity. An appropriate amount of each skin preparation from the Examples and Comparative Examples was then applied, and a sensory evaluation of the skin translucency after use was carried out using the following scoring system. The evaluation criteria were based on the average of the scores for translucency from the 10 panelists, and the results were classified as follows: <Transparency rating and details> 5 points: After use, the skin feels very clear. 4 points: After use, the skin feels slightly clearer. 3 points: After use, I feel that my skin is slightly clearer. 2 points: After use, I feel that my skin is slightly clearer. 1 point: My skin doesn't feel any clearer after using it. (Transparency evaluation criteria) ◎: Excellent (average score of 10 people was 4 points or more) ○: Good (the average score of 10 people was 3 points or more but less than 4 points) △: Slightly poor (the average score of 10 people was 2 points or more but less than 3 points) ×: Poor (the average score of 10 people was less than 2 points)
[0033] 2. Evaluation test of changes in skin clarity over time The above-mentioned "skin transparency evaluation test" was also performed on the topical skin preparations of the Examples and Comparative Examples stored at 45°C for one month using the same test system and evaluation method, and the amount of change in the sensory evaluation over time was calculated. The amount of change in the skin transparency evaluation was calculated using the following formula. <Changes in skin clarity evaluation> Change in skin transparency evaluation = {Scores of the topical skin preparations of Examples and Comparative Examples in the above "Skin Transparency Evaluation Test"} - {Scores of the topical skin preparations of Examples and Comparative Examples stored at 45°C for 1 month}
[0034] 3. Skin elasticity evaluation test The cheeks of 10 expert panel members were washed with soap, and then conditioned for 20 minutes in an environment of 25°C and 50% relative humidity. After that, 0.1 mL / cm of the topical skin preparations according to the examples and comparative examples of the present invention were applied to the cheeks. 2 After application, the skin was allowed to acclimate for 60 minutes in an environment of 25°C and 50% relative humidity, and then the skin's viscoelasticity was measured using a Cutometer (MPA580, manufactured by Courage+Khazaka). The skin elasticity improvement effect was evaluated by calculating the elasticity change rate (%) using the following formula, obtaining the average value for 10 subjects, and based on the following criteria. The results are shown in the table. <Calculation formula> Elasticity change rate (%) = (skin elasticity 60 minutes after application / skin elasticity before application) x 100 (Skin elasticity evaluation criteria) ◎: Elasticity change rate (%) was 150% or more. ○: The elasticity change rate (%) was 120% or more and less than 150%. △: Elasticity change rate (%) was 100% or more and less than 120%. ×: The elasticity change rate (%) was less than 100%.
[0035] 4. Evaluation test of color difference change in the appearance of topical skin preparations over time The topical skin preparations of the present invention and comparative examples were measured using a colorimeter (ZE 6000, manufactured by Nippon Denshoku Industries Co., Ltd.) and the b* values were quantified. The values were quantified for the products immediately after production and for the products stored at 45°C for one month, and the color difference change Δb* was calculated using the following formula. <Score for redness reduction effect> Δb* = (b* value of topical skin preparations of Examples and Comparative Examples stored at 45°C for 1 month / b* value of topical skin preparations of Examples and Comparative Examples immediately after production) × 100 (Evaluation criteria for color difference change) ⊚: The change in color difference was less than 15. ◯: The amount of change in color difference was 15 or more and less than 30. △: The amount of change in color difference was 30 or more and less than 45. ×: The amount of change in color difference was 45 or more.
[0036] 5. Non-stickiness evaluation test Ten expert panelists washed their forearms with lukewarm water and then allowed them to acclimate for 20 minutes in an environment at 25°C and 50% relative humidity. Then, an appropriate amount of each skin preparation from the Examples and Comparative Examples was applied, and a sensory evaluation was conducted on the stickiness of the skin during and after use using the following scoring system. The evaluation criteria were based on the average of the scores of the 10 panelists regarding the lack of stickiness, and the results were classified as follows: <Scores and details regarding non-stickiness> 5 points: Skin does not feel sticky during or after use. 4 points: Skin feels slightly sticky during and after use. 3 points: Skin feels slightly sticky during and after use. 2 points: Skin feels sticky during and after use. 1 point: The skin feels very sticky during and after use, which is uncomfortable. (Evaluation criteria for non-stickiness) ◎: Excellent (average score of 10 people was 4 points or more) ○: Good (the average score of 10 people was 3 points or more but less than 4 points) △: Slightly poor (the average score of 10 people was 2 points or more but less than 3 points) ×: Poor (the average score of 10 people was less than 2 points)
[0037] <Examples 1 to 14 and Comparative Examples 1 to 3> The topical skin preparations having the formulations of Examples 1 to 14 and Comparative Examples 1 to 3 shown in Tables 1 and 2 were prepared by conventional methods and evaluated by the respective test methods.
[0038] [Table 1]
[0039] [Table 2]
[0040] As is clear from Tables 1 and 2, all of the topical skin preparations of the Examples had excellent performance. In particular, the change in color difference in appearance over time was small, and there was no fading of the hydrolyzed gardenia extract over time. It was also shown that the water content was sufficient and that the product could be applied to a wide range of preparations. On the other hand, the comparative example was inferior in any of the following aspects: skin transparency, change in skin transparency evaluation over time, skin elasticity, change in color difference in appearance over time, non-stickiness, and stability, and the object of the present invention could not be achieved.
[0041] Other examples are listed below as formulation examples to demonstrate that the topical skin preparation of the present invention can be applied to a wide range of formulations. The topical skin preparations of these formulation examples were also examined for the above-mentioned skin transparency, changes in skin transparency evaluation over time, skin elasticity, changes in color difference in appearance over time, non-stickiness, and stability, and were found to have excellent properties in all respects.
[0042] Formulation example 1 (beauty serum) (mass%) (1) Hydrolyzed Gardenia Extract 3.0% (2) Angelica keiskei leaf / stem extract 0.4% (3) Bilberry Leaf Extract 0.2% (4) Glucosylceramide 0.01% (5) Retinol palmitate 0.1% (6) Ascorbic acid 2-glucoside 3.0% (7) L-Ascorbic acid sulfate disodium 0.7% (8) Loquat Fruit Extract 0.4% (9) Rose water 2.0% (10) Job's Tears Seed Extract 0.01% (11) Agar 0.1% (12) Diphenylsiloxyphenyl trimethicone 0.3% (13) Trimethylsiloxyphenyl dimethicone 0.2% (14) Phenyl trimethicone 0.01% (15) Yuzu Fruit Extract 0.4% (16) PEG-20 0.07% (17) PEG-400 0.5% (18) Polyglycerin-6 0.1% (19) Methylgluceth-20 5.0% (20) Glycerin 10.0% (21) Dipropylene glycol 3.0% (22) 1,3-butylene glycol 0.5% (23) EDTA-2Na 0.01% (24) Xanthan gum 0.01% (25) Carboxyvinyl polymer 0.2% (26) Alkyl-modified carboxyvinyl polymer 0.01% (27) Trisodium Hydroxyethylethylenediaminetriacetate 0.001% (28) PPG-13 decyltetradeceth-24 0.5% (29) Polysorbate 20 0.1% (30) Polyglyceryl-10 myristate 1.5% (31) Citric acid 0.02% (32) Sodium citrate 0.004% (33)Fragrance 0.07% (34) Phenoxyethanol 0.1% (35) Methylparaben 0.5% (36) Purified water remainder
[0043] (Production method) (12) to (36) were heated to 80°C and dissolved uniformly. After cooling to room temperature, (1) to (11) were added and dissolved uniformly, and the mixture was filled into a container to prepare a beauty serum.
[0044] Formulation example 2 (sheet mask) (mass%) (1) Hydrolyzed Gardenia Extract 0.2% (2) Rice bran extract 2.0% (3) Water-soluble collagen 1.0% (4) Glucosyltrehalose 0.01% (5) Betaine 0.01% (6) Royal jelly extract 0.02% (7) Ascorbic acid 2-glucoside 0.1% (8) Sage Leaf Extract 0.6% (9) Lemon Fruit Extract 0.5% (10) α-glucan 1.5% (11) PEG-250 2.5% (12) Sodium polyacrylate 1.0% (13) Dipropylene glycol 3.0% (14) Copper chlorophyll 0.01% (15) Alkyl-modified carboxyvinyl polymer 0.15% (16) PEG-10 glyceryl triisostearate 0.1% (17) (PCA / Isostearic acid) PEG-40 Hydrogenated Castor Oil 0.1% (18) PEG-60 hydrogenated castor oil 0.1% (19) Monopotassium phosphate 0.09% (20) Disodium phosphate 0.01% (21) Methylparaben 0.005% (22) Cyclohexylglycerin 0.5% (23) Squalane 0.1% (24) PEG-11 methyl ether dimethicone 0.05% (25) Ethylhexyl palmitate 0.1% (26) Diphenylsiloxyphenyl trimethicone 0.5% (27) Purified water remainder
[0045] (Production method) (1) to (22) and (27) were heated to 80°C and stirred to dissolve uniformly (Liquid A). (23) to (26) were heated to 80°C and stirred to disperse uniformly (Liquid B). Liquid B was added to Liquid A and dispersed uniformly using a homomixer, and then cooled to 30°C to prepare a beauty serum. The prepared beauty serum was then impregnated into a nonwoven fabric sheet to prepare a sheet mask.
[0046] Formulation example 3 (whitening makeup base cream) (mass%) (1) Gardenia blue liquid 0.5% (2) Bilberry Leaf Extract 0.9% (3) Japanese Knotweed Root Extract 1.2% (4) Peony extract 0.1% (5) Glycine 8.0% (6) Scutellaria root extract 0.75% (7) D-Pantothenyl alcohol 0.05% (8) Chamomile flower extract 0.0003% (9) Gardenia fruit extract 2.5% (10) Licorice Root Extract 5.0% (11) Althea Root Extract 0.0007% (12) Aloe vera juice 0.85% (13) Fennel Fruit Extract 1.0% (14) Turmeric extract 0.02% (15) Coenzyme Q10 0.001% (16) Cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 0.75% (17) Dipotassium glycyrrhizinate 0.2% (18) Ascorbic acid 2-glucoside 2.0% (19) Tranexamic acid 3.0% (20) Sodium N-stearoyl-L-glutamate 0.5% (21) Sorbitan monoisostearate 0.1% (22) PEG-10 glyceryl triisostearate 0.2% (23) PEG-60 hydrogenated castor oil 0.9% (24) Carboxyvinyl polymer 0.1% (25) Xanthan gum 0.01% (26) Hydrophobized hydroxypropyl methylcellulose 0.01% (27) Potassium hydroxide 0.02% (28) L-Arginine 0.01% (29) Citric acid 0.01% (30) Dipotassium phosphate 0.04% (31)Tartaric acid 0.01% (32) Triethanolamine 0.02% (33) Ethylparaben 0.05% (34) Methylparaben 0.05% (35) Phenoxyethanol 0.5% (36) 3-O-Ethyl ascorbic acid 0.01% (37) Retinol palmitate 0.01% (38) dl-α-Tocopherol Nicotinate 0.05% (39) Mineral oil 7.0% (40) Octyldodecyl myristate 2.0% (41) Squalane 1.0% (42) Tri(caprylic / capric / myristic / stearic acid) Glyceryl Glyceryl 0.5% (43) Zinc oxide 0.1% (44) Di(phytosteryl / isostearyl / dilinoleate) Cetyl / Stearyl / Behenyl) 0.3% (45) White Beeswax 1.2% (46) Sodium cetyl sulfate 0.5% (47) Phenyl trimethicone 0.3% (48) Methylphenylpolysiloxane 1.0% (49) Diphenyl trimethicone 0.1% (50) Purified water remainder
[0047] (Production method) (20) to (35) and a portion of (50) were heated to approximately 80°C and stirred to dissolve uniformly (liquid A). (36) to (49) were heated to approximately 80°C and stirred to dissolve uniformly (liquid B). Liquid A was added to liquid B and dispersed using a homomixer. The mixture was then cooled, and a solution of (1) to (19) in the remainder of (50) at 40°C was added and further dissolved uniformly. The mixture was again cooled to 30°C to prepare a whitening makeup base cream.
[0048] Formulation example 4 (gel cream) (mass%) (1) Hydrolyzed Gardenia Extract 0.58% (2) Rice bran extract 0.22% (3) White clover extract 0.41% (4) Tranexamic acid 2.0% (5) Aminobutyric acid 0.05% (6) Guaiazulene 0.01% (7) Glucosylceramide 0.1% (8) Glycereth-26 0.5% (9) Arginine 0.1% (10) Edetate disodium 0.01% (11) PEG-20 0.01% (12) Behenyl alcohol 1.0% (13) Sodium stearoyl glutamate 1.2% (14) Carboxyvinyl polymer 0.2% (15) (Acrylates / C10-30 alkyl acrylate) Crosspolymer 0.1% (16)HEDTA-3Na 0.005% (17) Citric acid 0.01% (18) Potassium hydroxide 0.22% (19) Caramel 0.2% (20) 1,3-butylene glycol 5.0% (21) Glyceryl monostearate 3.0% (22) Octyldodecyl myristate 0.5% (23) Methylpolysiloxane (6CS) 1.5% (24) Diphenylsiloxyphenyl trimethicone 0.05% (25) Beeswax 1.0% (26) Ceramide III 0.1% (27) Polyglyceryl-10 myristate 0.5% (28) Sorbitan isostearate 0.2% (29) Pure water remainder
[0049] Manufacturing method) (9) to (20) and (29) were heated to 80°C and uniformly dissolved (liquid A). (21) to (28) were uniformly dissolved and then heated to 80°C (liquid B). Liquid A was added to liquid B, and the mixture was dispersed using a homomixer. The mixture was then cooled to room temperature to prepare a gel cream.
[0050] Formulation example 5 (wrinkle concealing cream) (mass%) (1) Hydrolyzed Gardenia Extract 0.07% (2) Bilberry Leaf Extract 0.1% (3) Glucosylceramide 1.0% (4) Hydrolyzed collagen 0.05% (5) Lactobacillus / Pear Juice Fermentation Filtrate 0.5% (6) Silk hydrolyzate 0.3% (7) Rosa multiflora fruit extract 0.08% (8) Rosemary Leaf Extract 0.32% (9) Brown algae extract 0.001% (10) Red algae extract 0.25% (11) Green algae extract 0.001% (12) Saccharomyces / Rice Fermentation Liquid 0.09% (13) Ethanol 15.0% (14) Polyoxyethylene (2) alkyl (12-15) phosphate 0.5% (15) Polyoxyethylene (2) oleyl ether 0.5% (16) PEG-60 hydrogenated castor oil 0.5% (17) Polyvinylpyrrolidone 0.1% (18) Carboxyvinyl polymer 0.3% (19) Potassium hydroxide 0.15% (20) Edetate disodium 0.05% (21)Fragrance 0.1% (22) Phenoxyethanol 0.2% (23) Liquid paraffin 5.0% (24) Methylpolysiloxane (100cs) 1.0% (25) Vaseline 1.0% (26) Diphenyl trimethicone 1.5% (27) Diphenylsiloxyphenyl trimethicone 1.0% (28) Purified water remainder
[0051] (Production method) (14) to (22) are added to (28) and heated to 70°C to dissolve uniformly (liquid A). (23) to (27) are heated to 60°C to disperse uniformly, and added to liquid A and dispersed using a homomixer. Next, (1) to (13) are added and stirred, and the mixture is filled into a tube container to prepare a wrinkle concealing cream.
[0052] Formulation example 6 (skin texture improving serum) (mass %) (1) Hydrolyzed Gardenia Extract 1.3% (2) Bilberry Leaf Extract 7.0% (3) PEG-75 1.0% (4) Birch bark extract 0.001% (5) Tea leaf extract 0.01% (6) Hydrolyzed elastin 0.5% (7) Rice bran extract 0.3% (8) PEG-20 0.2% (9) English: ... (10) Elderberry Extract 0.5% (11) Parietaria extract 0.75% (12) Arnica flower extract 0.3% (13) Soybean Seed Extract 0.1% (14) Grape Leaf Extract 0.1% (15) Hypericum perforatum flower / leaf / stem extract 0.07% (16) Hamamelis leaf extract 0.1% (17) Horse Chestnut Leaf Extract 0.1% (18) Fuyubotaiju extract 0.004% (19) Calendula officinalis flower extract 0.25% (20) Cornflower flower extract 0.1% (21) Roman chamomile flower extract 0.0001% (22) peach leaf extract 0.0005% (23) cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol 0.01% (24) (Sodium acrylate / sodium acryloyldimethyltaurate) Copolymer 0.2% (25) Polyquaternium-52 0.1% (26) POE(60) hydrogenated castor oil 0.1% (27) 1,3-butylene glycol 3.0% (28) Glycerin 5.0% (29) Methylgluceth-20 2.0% (30) Sorbitol 2.0% (31) Maltitol 2.0% (32) Diisopropanolamine 0.05% (33) Potassium hydroxide 0.05% (34) Carboxyvinyl polymer 0.05% (35) Alkyl-modified carboxyvinyl polymer 0.12% (36) Xanthan gum 0.1% (37) Edetate disodium 0.01% (38) Sodium pyrosulfite 0.005% (39) Octyldodecyl myristate 3.0% (40) Cholesterol 0.5% (41) Diphenylsiloxyphenyl trimethicone 1.2% (42) Purified water remainder
[0053] (Production method) (1) to (38) and (42) were uniformly dissolved at 80°C, and (39) to (41) were uniformly dispersed at 80°C. The mixture was added to the solution, dispersed using a homomixer, and then cooled to prepare a texture-improving serum.
[0054] Formulation example 7 (Sunscreen) (mass%) (1) Hydrolyzed Gardenia Extract 0.1% (2) Rice bran extract 0.2% (3) Sodium hyaluronate 1.0% (4) Ethanol 15.0% (5) Dipropylene glycol 6.0% (6) Ethylhexyl methoxycinnamate 4.0% (7) Diethylaminohydroxybenzoylhexyl benzoate 1.0% (8) Bis-ethylhexyloxyphenol Methoxyphenyltriazine 1.0% (9) t-Butyl methoxydibenzoylmethane 6.0% (10) Starch octenyl succinate aluminum 0.2% (11) POE·POP modified dimethylpolysiloxane 1.0% (12) Octyldodecyl myristate 5.0% (13) Isononyl isononanoate 1.0% (14) Diphenylsiloxyphenyl trimethicone 8.0% (15) Methylcyclopolysiloxane 1.0% (16) Dimethylpolysiloxane 1.0% (17) Hydrogenated lecithin 0.08% (18) Phytosterol 0.8% (19) DL-α-Tocopherol Acetate 0.1% (20) Scutellaria root extract 0.5% (21) Lithospermum Root Extract 0.05% (22) Angelica acutiloba root extract 0.02% (23) Royal Jelly Extract 1.2% (24) Orange flower water 0.001% (25) Aloe vera leaf extract 0.01% (26) Sodium chondroitin sulfate 0.1% (27) Ceramide NG 0.3% (28) Acetylglucosamine 0.2% (29) Bentonite 0.5% (30) Disteardimonium hectorite 0.1% (31) Silica-coated zinc oxide 2.0% (32) Purified water remainder
[0055] (Production method) (1) to (3) are added to (31) heated to 80°C and dissolved (Liquid A). (5), (16) to (32) are added and heated to 80°C to disperse uniformly (Liquid B). (6) to (15) are heated to 70°C to dissolve uniformly (Liquid C). Liquids B and C are added to Liquid A in this order, mixed uniformly using a homomixer, and then cooled to 50°C. (4) and (10) are added to this, mixed further uniformly using a homomixer, and then cooled to obtain the sunscreen.
Claims
1. A topical skin preparation containing the following components (A) and (B): (A) Hydrolyzed Gardenia Extract (B) Bilberry leaf extract and / or rice bran extract
2. The amount of component (A) is 0.0001 to 3% by mass relative to the total mass of the topical skin preparation, The amount of component (B) is 0.00001 to 3% by mass relative to the total mass of the topical skin preparation, 2. The external skin preparation according to claim 1, wherein the ratio (A / B) of the amount of component (A) to the amount of component (B) is 0.05 to 25.
Citation Information
Patent Citations
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