Kit or device and method for detecting dementia

Abstract

To provide a kit or a device and a detection method for detecting dementia.SOLUTION: Provided are a kit or a device for detecting dementia which includes a nucleic acid capable of specifically binding to miRNA in a sample of a subject or a complementary strand thereof, and a method for detecting dementia including measuring the miRNA in vitro.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a specific miRNA used to test for the presence or absence of dementia in a subject. A kit or device for detecting dementia, comprising a nucleic acid capable of specifically binding to RNA or its complementary strand. The present invention relates to a method for detecting dementia, which comprises measuring the expression level of the miRNA. [Background technology]

[0002] Future estimates of the number and prevalence of dementia patients among people aged 65 and over in Japan In 2012, 4.62 million people (1 in 7 people aged 65 or over (prevalence rate 15.0%)) ), but by 2025, this will be about 7 million (one in five people aged 65 or over). (Cabinet Office, 2016 White Paper on Aging Society) The cost of nursing care in 2014 was 14.5 trillion yen (breakdown: medical expenses 1.9 trillion yen (hospitalization approximately 9 trillion yen) 70.3 billion yen, outpatient costs approximately 941.2 billion yen), nursing care costs 6.4 trillion yen (home care costs approximately 3.5281 trillion yen, It was reported that the cost of public health care reached approximately 2.916 trillion yen and the cost of informal care reached 6.2 trillion yen. (Ministry of Health, Labor and Welfare Research Group, "Estimation of the Social Cost of Dementia," May 2015). However, by 2030, the number of dementia patients is expected to increase to 74.7 million, and the cost of dementia care will The estimated cost is estimated at 240 trillion yen (ADI, World Alzheimer's Research Dementia is generally progressive and causes irreversible degeneration of brain nerve cells. Currently, there are no drugs to treat dementia, so in order to reduce the burden on patients and caregivers as well as the social costs, Therefore, it is important to examine and diagnose dementia and provide early medical intervention to prevent its progression. .

[0003] Currently, dementia is diagnosed based on medical history, current symptoms, physical examination, neuropsychological tests, blood tests, imaging tests, etc. This is done through differential diagnosis.

[0004] As a method for examining dementia using neuropsychological tests, Folstein's "Mini-Mental State" The MMSE (Multi-Mental State Examination) is the most widely used internationally and has the advantages of sensitivity, specificity, simplicity and Given the amount of data accumulated to date, this is the most recommended screening test. The total score is 30 points, and the tests include orientation, memory, attention and calculation, language function, verbal command, and figure copying. It is possible to easily evaluate multiple cognitive functions such as dementia, and a score of 23 points or less is generally considered to be a sign of dementia. However, depending on educational and work history, it is possible to judge whether a person has dementia or not. However, such interview methods should be used only for screening purposes. However, no definitive diagnosis can be reached.

[0005] Imaging tests for dementia include CT, MRI, PET / SPECT, etc. However, diagnostic imaging requires special equipment, making it difficult to carry out. There are only a limited number of medical institutions that can perform this treatment. In addition, current imaging diagnostic technology is unable to detect dementia at an early stage. It is difficult to distinguish between normal and normal cognitive function, so the judgement depends on the doctor who looks at the images. The results may differ and have the drawback of being less objective.

[0006] The blood tests recommended in the dementia diagnostic disease guidelines are for Alzheimer's disease and other dementias. In the diagnosis of degenerative dementia, to exclude medical diseases that cause dementia and dementia-like symptoms However, at present, there are no blood tests that can identify dementia. Cerebrospinal fluid (CSF) in Zheimer's dementia d) Low amyloid protein levels and high tau levels are used as surrogate markers. However, there is a problem that it is highly invasive for the patient.

[0007] In recent years, markers for diagnosing dementia such as Alzheimer's disease and neurodegenerative diseases have been developed. Development is currently underway.

[0008] For example, six miRNAs (miR-483-5p, miR-486- 5p, miR-30b-5p, miR-200a-3p, miR-502-3p, miR -142-3p) to identify mild cognitive impairment (MCI), a precursor to dementia. It has been reported that it is possible to diagnose early Alzheimer's disease (Non-Patent Document 1). Subjects with dementia were asked to take a supplement that alleviates the symptoms of dementia, and serum As a result of an attempt to search for dementia markers by comparing the expression of miRNAs in the brain, 21 miRNAs were identified. Car (hsa-miR-486-5p, hsa-miR-21-5p, hsa-miR- 92a-3p, hsa-miR-451a, hsa-let-7b-5p, hsa-mi R-126-3p, hsa-miR-25-3p, hsa-miR-10b-5p, hs a-miR-30e-5p, hsa-miR-140-3p, hsa-miR-101- 3p, hsa-miR-222-3p, hsa-miR-10a-5p, hsa-miR -221-3p, hsa-miR-375, hsa-miR-30a-5p, hsa-m iR-584-5p, hsa-miR-27b-3p, hsa-miR-484, hsa -miR-125a-5p, hsa-miR-93-5p, etc.) have been reported to be extracted. (Patent Document 1).

[0009] Specific miRNA targets for the prevention and treatment of neurodegenerative diseases, especially Alzheimer's disease In the search, miR-206 was identified (Patent Document 2). The neurotransmitter chain increases the levels of nerve growth factor BDNF and IGF-1, leading to synaptic regeneration. The researchers confirmed this in Alzheimer's disease model mice and reported that this marker could also be used for diagnosis. is doing.

[0010] Aiming to diagnose Alzheimer's disease, 67 miRs (hsa-miR-1296, hs miR-424*, hsa-miR-424, hsa-miR-629, etc. It has been reported that Alzheimer's disease can be diagnosed by measuring RNA expression levels (e.g., Reference 3).

[0011] Neural tissue and synaptic miRNAs (miR-7, miR-25, miR-26a) in body fluids ) for diagnosing mild dementia and Alzheimer's disease and monitoring treatment. It has been reported that this is possible (Patent Document 4).

[0012] Patent Document 5 describes the treatment of Alzheimer's disease and neurofibrillary degeneration caused by abnormal tau expression, and Search for miRNAs that bind to the 3'UTR of tau mRNA and regulate tau expression for the purpose of prevention The therapeutic markers obtained as a result of the It has been reported that these methods (e.g., MRI, MRI, etc.) can also be applied to diagnosis.

[0013] We isolated vesicles derived from microglia present in body fluids and analyzed the miRNAs contained therein. The aim is to diagnose, predict, and monitor treatment for neurodegenerative diseases through expression analysis. It has been reported that 36 miRNAs have been identified (Patent Document 6).

[0014] Patent Document 7 discloses a microfluidic device that hybridizes and detects microRNA. For the purpose of development, detection, for example, of cancer and inflammatory diseases in body fluids including blood, serum, and plasma reported detecting microRNAs associated with dementia.

[0015] On the other hand, it has become clear that dementia can occur in combination with many other types of illness. For example, in a report comparing the doctor's diagnosis and the pathological diagnosis, Of the 447 patients diagnosed with Alzheimer's disease, the pathological diagnosis was Only 14 people (3.13%) had dementia, and in addition to Alzheimer's disease, 366 people (81.88%) had concurrent vascular dementia or Lewy body dementia. It has been reported that the patient had been diagnosed with Alzheimer's disease by a doctor (Non-Patent Document 2). Of the 477 patients diagnosed, 67 (14.98%) had pathologically diagnosed Alzheimer's disease. Dementia or Alzheimer's dementia with other dementias than Alzheimer's dementia, but not blood dementia that is different from Alzheimer's disease, such as vascular dementia, dementia with Lewy bodies, and hippocampal atrophy The patient had dementia (Non-patent document 2). [Prior art documents] [Patent documents]

[0016] [Patent Document 1] Japanese Patent Application Laid-Open No. 2017-184642 [Patent Document 2] US Patent Application Publication No. 2013 / 0184331 [Patent Document 3] US Patent Application Publication No. 2014 / 0206777 [Patent Document 4] US Patent Application Publication No. 2014 / 0120545 [Patent Document 5] US Patent Application Publication No. 2017 / 0002348 [Patent Document 6] International Publication No. 2017 / 084770 [Patent Document 7] International Publication No. 2017 / 059094 [Non-patent literature]

[0017] [Non-Patent Document 1] Siranjeevi N. et al., Oncotarget, 2017 Feb 05, vol.8, No.10, p.16122-16143 [Non-patent document 2] Alifiya Kapasi et al., Acta Neuropathol, 2017, vol.134, p.171-186 Summary of the Invention [Problem to be solved by the invention]

[0018] As mentioned above, dementia is generally progressive and involves irreversible degeneration of brain nerve cells. Therefore, it is essential to detect the disease without fail and to carry out medical intervention aimed at preventing its progression. In addition, in order to provide medical interventions such as prescription of drugs to suppress progression and cognition to suppress progression, A diagnostic method that can objectively detect multiple types of dementia without overlooking them, regardless of the symptom type, is needed. However, as mentioned above, diagnosing dementia is not easy, and the diagnosis depends on the doctor. The diagnostic methods used are subjective and vary widely, and many dementias are comorbid. Therefore, if only certain types of dementia are diagnosed, other types of dementia may be overlooked and treatment may be unavailable. Because there is a possibility that the patient may lose contact with others, it is necessary to provide an objective and comprehensive diagnosis of dementia. However, the markers described in Non-Patent Document 1 and Patent Documents 1 to 7 are The markers identified have sufficient performance as markers for diagnosing dementia, as described below. It could not be said that they had

[0019] In Non-Patent Document 1, the term "mild cognitive impairment (MCI)" includes early Alzheimer's disease and Alzheimer's disease. It has only been verified for Alzheimer's dementia, and not for other dementias It is unclear whether this type of dementia can be detected.

[0020] In Patent Document 1, only MCI, which is a pre-dementia stage, was examined, and dementia It is unclear whether it can be detected.

[0021] In Patent Document 2, only verification was carried out using Alzheimer's model mice and human brain samples. However, there has been no verification using blood samples that can be collected minimally invasively.

[0022] Patent Document 3 only targets Alzheimer's dementia, It is unclear whether other types of dementia can be detected.

[0023] Patent Document 4 describes how to distinguish between MCI and healthy individuals, and between MCI and Alzheimer's dementia. However, it is not possible to distinguish between healthy individuals and those with Alzheimer's disease.

[0024] In Patent Document 5, only verification using brain tissue is reported as an example, and the same was not reported for blood samples. It is unclear whether it can be detected in the same way.

[0025] Patent Document 6 investigates whether markers are expressed in microglial cells of model mice. It has only been verified in human blood samples, and it is unclear whether the marker can be detected using human blood samples. .

[0026] Patent Document 7 relates to a diagnostic device using microRNA in body fluids, and is intended to detect cancer and inflammatory diseases. Dementia is also exemplified. MicroRNA analysis using samples including blood, serum, and plasma Although there is a description of the detection of the marker, there are no examples, and the marker has not been detected using human blood samples. It is unclear whether this can be done.

[0027] As mentioned above, previous reports on dementia markers have used a single type of dementia sample. Only validation has been performed, and if these markers are used for diagnosis, other cognitive There is a possibility that treatment opportunities may be missed due to overlooking symptomatic patients. The report evaluates the drug using model mice and human brain samples, and verification using human blood has not been performed. Therefore, it may not be suitable for diagnosing dementia.

[0028] In addition, collecting cerebrospinal fluid as a measurement sample is highly invasive to the patient and is therefore not preferred. Since it is not necessary to collect blood samples, it can be detected using minimally invasive methods, making it possible to accurately determine whether or not someone has dementia. A comprehensive dementia marker that can distinguish dementia is desired. In this case, medical intervention can be expected to slow the progression of dementia.

[0029] The object of the present invention is to provide a method for identifying one or more dementia types that can distinguish between dementia and cognitively normal (non-dementia) patients. The present invention provides a dementia marker that can be used to diagnose dementia, and uses a nucleic acid that can specifically bind to the marker. The object of the present invention is to provide a method for objectively and effectively detecting whether or not a person has dementia. In terms of the results, 1. there are no differences between medical facilities or doctors, and 2. multiple types of dementia can be comprehensively detected. 3. High sensitivity and specificity for detecting dementia, 4. Minimal invasiveness. The purpose of the present invention is to provide an inspection method that satisfies at least all of the above. [Means for solving the problem]

[0030] As a result of intensive research to solve the above problems, the present inventors have found that Alzheimer's disease, vascular One of the following conditions is selected from dementia, dementia with Lewy bodies, normal pressure hydrocephalus, frontotemporal lobar degeneration, etc. The present invention was accomplished by discovering novel dementia markers that can detect the above types of dementia. I arrived.

[0031] <Summary of the Invention> That is, the present invention includes the following aspects. (1) Dementia markers: miR-4274, miR-4272, and miR-4728 -5p, miR-4443, miR-4506, miR-6773-5p, miR-46 62a-5p, miR-3184-3p, miR-4281, miR-320d, miR -6729-3p, miR-5192, miR-6853-5p, miR-1234-3 p, miR-1233-3p, miR-4539, miR-3914, miR-4738 -5p, miR-548au-3p, miR-1539, miR-4720-3p, mi R-365b-5p, miR-4486, miR-1227-5p, miR-4667- 5p, miR-6088, miR-6820-5p, miR-4505, miR-548 q, miR-4658, miR-450a-5p, miR-1260b, miR-367 7-5p, miR-6777-3p, miR-6826-3p, miR-6832-3p , miR-4725-3p, miR-7161-3p, miR-2277-5p, miR -7110-3p, miR-4312, miR-4461, miR-6766-5p, m iR-1266-3p, miR-6729-5p, miR-526b-3p, miR-5 19e-5p, miR-512-5p, miR-5088-5p, miR-1909-3 p, miR-6511a-5p, miR-4734, miR-936, miR-1249 -3p, miR-6777-5p, miR-4487, miR-3155a, miR-5 63, miR-4741, miR-6788-5p, miR-4433b-5p, miR -323a-5p, miR-6811-5p, miR-6721-5p, miR-500 4-5p, miR-6509-3p, miR-648, miR-3917, miR-60 87, miR-1470, miR-586, miR-3150a-5p, miR-105 -3p、miR-7973、miR-1914-5p、miR-4749-3p、miR -15b-5p, miR-1289, miR-4433a-5p, miR-3666, m iR-3186-3p, miR-4725-5p, miR-4488, miR-4474 -3p, miR-6731-3p, miR-4640-3p, miR-202-5p, m iR-6816-5p, miR-638, miR-6821-5p, miR-1247- 3p, miR-6765-5p, miR-6800-5p, miR-3928-3p, m iR-3940-5p, miR-3960, miR-6775-5p, miR-3178 miR-1202 miR-6790-5p miR-4731-3p miR-26 81-3p, miR-6758-5p, miR-8072, miR-518d-3p, m iR-3606-3p, miR-4800-5p, miR-1292-3p, miR-6 784-3p, miR-4450, miR-6132, miR-4716-5p, miR -6860, miR-1268b, miR-378d, miR-4701-5p, miR -4329, miR-185-3p, miR-552-3p, miR-1273g-5p miR-6769b-3p miR-520a-3p miR-4524b-5p m iR-4291, miR-6734-3p, miR-143-5p, miR-939-3 p, miR-6889-3p, miR-6842-3p, miR-4511, miR-4 318, miR-4653-5p, miR-6867-3p, miR-133b, miR -3196, miR-193b-3p, miR-3162-3p, miR-6819-3 p, miR-1908-3p, miR-6786-5p, miR-3648, miR-4 513, miR-3652, miR-4640-5p, miR-6871-5p, miR -7845-5p, miR-3138, miR-6884-5p, miR-4653-3 p, miR-636, miR-4652-3p, miR-6823-5p, miR-45 02、miR-7113-5p、miR-8087、miR-7154-3p、miR- 5189-5p, miR-1253, miR-518c-5p, miR-7151-5p miR-3614-3p miR-4727-5p miR-3682-5p miR -5090, miR-337-3p, miR-488-5p, miR-100-5p, m iR-4520-3p, miR-373-3p, miR-6499-5p, miR-39 09, miR-32-5p, miR-302a-3p, miR-4686, miR-46 59a-3p, miR-4287, miR-1301-5p, miR-593-3p, m iR-517a-3p, miR-517b-3p, miR-142-3p, miR-11 85-2-3p, miR-602, miR-527, miR-518a-5p, miR- 4682, miR-28-5p, miR-4252, miR-452-5p, miR-5 25-5p, miR-3622a-3p, miR-6813-3p, miR-4769- 3p、miR-5698、miR-1915-3p、miR-1343-5p、miR- 6861-5p, miR-6781-5p, miR-4508, miR-6743-5p miR-6726-5p miR-4525 miR-4651 miR-6813- 5p, miR-5787, miR-1290, miR-6075, miR-4758-5 p, miR-4690-5p, miR-762, miR-371a-5p, miR-67 65-3p, miR-6784-5p, miR-6778-5p, miR-6875-5 p、miR-4534、miR-4721、miR-6756-5p、miR-615- 5p, miR-6727-5p, miR-6887-5p, miR-8063, miR- 6880-5p, miR-6805-3p, miR-4726-5p, miR-4710 miR-7111-5p miR-3619-3p miR-6795-5p miR -1254、miR-1233-5p、miR-6836-3p、miR-6769a- 5p, miR-4532, miR-365a-5p, miR-1231, miR-122 8-5p, miR-4430, miR-296-3p, miR-1237-5p, miR -4466, miR-6789-5p, miR-4632-5p, miR-4745-5 p, miR-4665-5p, miR-6807-5p, miR-7114-5p, mi R-516a-5p, miR-769-3p, miR-3692-5p, miR-394 5, miR-4433a-3p, miR-4485-3p, miR-6831-5p, m iR-519c-5p, miR-551b-5p, miR-1343-3p, miR-4 286, miR-4634, miR-4733-3p, and miR-6086 or a complementary strand of the polynucleotide. A kit for detecting dementia, comprising a nucleic acid capable of binding. (2) The nucleic acid is a polynucleotide represented by any one of the following (a) to (e): (a) any of SEQ ID NOs: 1 to 210, 374, 1315 to 1350, and 1435 to 1448 or a base sequence in which u is t in the base sequence A polynucleotide, its variant, derivative, or fragment containing 15 or more consecutive bases piece, (b) any of SEQ ID NOs: 1 to 210, 374, 1315 to 1350, and 1435 to 1448 A polynucleotide comprising a base sequence represented by any one of (c) SEQ ID NOs: 1 to 210, 374, 1315 to 1350, and 1435 to 1448 Complementary to the base sequence represented by either or the base sequence in which u is t a polynucleotide consisting of a base sequence identical to that of the nucleotide sequence of the present invention, a variant thereof, a derivative thereof, or a polynucleotide consisting of 15 or more consecutive bases a fragment thereof containing the base, (d) SEQ ID NOs: 1 to 210, 374, 1315 to 1350, and 1435 to 1448 Complementary to the base sequence represented by either or the base sequence in which u is t a polynucleotide containing a base sequence such as (e) combining any one of the polynucleotides (a) to (d) under stringent conditions hybridizing polynucleotides, The kit according to (1), wherein the polynucleotide is selected from the group consisting of: (3) The kit is for detecting another dementia marker, miR-1225-3p, miR-3 184-5p, miR-665, miR-211-5p, miR-1247-5p, mi R-3656, miR-149-5p, miR-744-5p, miR-345-5p, miR-150-5p, miR-191-3p, miR-651-5p, miR-34a -5p, miR-409-5p, miR-369-5p, miR-1915-5p, mi R-204-5p, miR-137, miR-382-5p, miR-517-5p, m iR-532-5p, miR-22-5p, miR-1237-3p, miR-1224 -3p, miR-625-3p, miR-328-3p, miR-122-5p, miR -202-3p, miR-4781-5p, miR-718, miR-342-3p, m iR-26b-3p, miR-140-3p, miR-200a-3p, miR-378 a-3p, miR-484, miR-296-5p, miR-205-5p, miR-4 31-5p, miR-150-3p, miR-423-5p, miR-575, miR- 671-5p, miR-939-5p, miR-3665, miR-30d-5p, mi R-30b-3p, miR-92a-3p, miR-371b-5p, and miR-48 6-5p, or one or more polynucleotides selected from the group consisting of The kit according to (1) or (2), further comprising a nucleic acid capable of specifically binding to a complementary strand of (4) The nucleic acid is a polynucleotide represented by any one of the following (f) to (j): (f) any of SEQ ID NOs: 211 to 249, 1351 to 1356, and 1449 to 1453 or a polynucleotide sequence in which u is t in the base sequence a nucleotide, a variant thereof, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases; (g) any of SEQ ID NOs: 211 to 249, 1351 to 1356, and 1449 to 1453 A polynucleotide comprising a base sequence represented by (h) any of SEQ ID NOs: 211 to 249, 1351 to 1356, and 1449 to 1453 A base sequence complementary to the base sequence represented by the above or the base sequence in which u is t A polynucleotide consisting of a base sequence, its variant, its derivative, or 15 or more consecutive salts a fragment thereof containing the group, (i) any of SEQ ID NOs: 211 to 249, 1351 to 1356, and 1449 to 1453 A base sequence complementary to the base sequence represented by the above or the base sequence in which u is t a polynucleotide comprising the base sequence, and (j) combining the polynucleotide of any one of (f) to (i) under stringent conditions hybridizing polynucleotides, The kit according to (3), wherein the polynucleotide is selected from the group consisting of:

[0032] (5) The kit is for detecting other dementia markers, such as miR-1471 and miR-1538. , miR-449b-3p, miR-1976, miR-4268, miR-4279, miR-3620-3p, miR-3944-3p, miR-3156-3p, miR- 3187-5p, miR-4685-3p, miR-4695-3p, miR-4697 -3p、miR-4713-5p、miR-4723-3p、miR-371b-3p、 miR-3151-3p, miR-3192-3p, miR-6728-3p, miR- 6736-3p, miR-6740-3p, miR-6741-3p, miR-6743 -3p、miR-6747-3p、miR-6750-3p、miR-6754-3p、 miR-6759-3p, miR-6761-3p, miR-6762-3p, miR- 6769a-3p, miR-6776-3p, miR-6778-3p, miR-677 9-3p, miR-6786-3p, miR-6787-3p, miR-6792-3p miR-6794-3p miR-6801-3p miR-6802-3p miR -6803-3p, miR-6804-3p, miR-6810-5p, miR-682 3-3p, miR-6825-3p, miR-6829-3p, miR-6833-3p miR-6834-3p miR-6780b-3p miR-6845-3p mi R-6862-3p, miR-6865-3p, miR-6870-3p, miR-68 75-3p, miR-6877-3p, miR-6879-3p, miR-6882-3 p, miR-6885-3p, miR-6886-3p, miR-6887-3p, mi R-6890-3p, miR-6893-3p, miR-6894-3p, miR-71 06-3p, miR-7109-3p, miR-7114-3p, miR-7155-5 p, miR-7160-5p, miR-615-3p, miR-920, miR-182 5, miR-675-3p, miR-1910-5p, miR-2278, miR-26 82-3p, miR-3122, miR-3151-5p, miR-3175, miR- 4323, miR-4326, miR-4284, miR-3605-3p, miR-3 622b-5p, miR-3646, miR-3158-5p, miR-4722-3p , miR-4728-3p, miR-4747-3p, miR-4436b-5p, mi R-5196-3p, miR-5589-5p, miR-345-3p, miR-642 b-5p, miR-6716-3p, miR-6511b-3p, miR-208a-5 p, miR-6726-3p, miR-6744-5p, miR-6782-3p, mi R-6789-3p, miR-6797-3p, miR-6800-3p, miR-68 06-5p, miR-6824-3p, miR-6837-5p, miR-6846-3 p, miR-6858-3p, miR-6859-3p, miR-6861-3p, mi R-6880-3p, miR-7111-3p, miR-7152-5p, miR-64 2a-5p, miR-657, miR-1236-3p, miR-764, miR-43 14, miR-3675-3p, miR-5703, miR-3191-5p, miR- 6511a-3p, miR-6809-3p, miR-6815-5p, miR-685 one or more polynucleotides selected from the group consisting of miR-7-3p, and miR-6878-3p (1) further comprising a nucleic acid capable of specifically binding to a strand of the polynucleotide, or a complementary strand of the polynucleotide; The kit according to any one of (1) to (4). (6) The nucleic acid is a polynucleotide represented by any one of the following (k) to (o): (k) a base sequence represented by any one of SEQ ID NOs: 250 to 373 or the base sequence a polynucleotide consisting of a base sequence in which u is t, a variant thereof, a derivative thereof, or a fragment thereof containing 5 or more consecutive bases; (l) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 250 to 373; (m) a base sequence represented by any one of SEQ ID NOs: 250 to 373 or the base sequence a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t, a variant thereof, its derivatives or fragments containing 15 or more consecutive bases; (n) a base sequence represented by any one of SEQ ID NOs: 250 to 373 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (o) combining any one of the polynucleotides (k) to (n) under stringent conditions hybridizing polynucleotides, The kit according to (5), wherein the polynucleotide is selected from the group consisting of: (7) The kit includes another dementia marker, miR-766-3p, miR-12 29-3p, miR-1306-5p, miR-210-5p, miR-198, miR -485-3p, miR-668-3p, miR-532-3p, miR-877-3p , miR-1238-3p, miR-3130-5p, miR-4298, miR-42 90, miR-3943, miR-346, and miR-767-3p. capable of specifically binding to one or more polynucleotides selected from the group consisting of nucleotides having a complementary strand to the polynucleotides The kit according to any one of (1) to (6), further comprising a nucleic acid capable of being used for the detection of a target gene. (8) The nucleic acid is a polynucleotide represented by any one of the following (p) to (t): (p) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide consisting of a base sequence in which u is t, a variant thereof, a derivative thereof, or a fragment thereof containing 5 or more consecutive bases; (q) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 375 to 390; (r) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t, a variant thereof, its derivatives or fragments containing 15 or more consecutive bases; (s) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (t) combining any one of the polynucleotides (p) to (s) under stringent conditions hybridizing polynucleotides, The kit according to (7), wherein the polynucleotide is selected from the group consisting of:

[0033] (9) Dementia markers miR-4728-5p, miR-3184-3p, and mi R-1233-3p, miR-6088, miR-6777-3p, miR-7110- 3p, miR-936, miR-6087, miR-1202, miR-4731-3p , miR-4800-5p, miR-6784-3p, miR-4716-5p, miR -6734-3p, miR-6889-3p, miR-6867-3p, miR-362 2a-3p, miR-6813-3p, miR-4769-3p, miR-5698, m iR-3184-5p, miR-1471, miR-1538, miR-449b-3p , miR-1976, miR-4268, miR-4279, miR-3620-3p, miR-3944-3p, miR-3156-3p, miR-3187-5p, miR- 4685-3p, miR-4695-3p, miR-4697-3p, miR-4713 -5p、miR-4723-3p、miR-371b-3p、miR-3151-3p、 miR-3192-3p, miR-6728-3p, miR-6736-3p, miR- 6740-3p, miR-6741-3p, miR-6743-3p, miR-6747 -3p、miR-6750-3p、miR-6754-3p、miR-6759-3p、 miR-6761-3p, miR-6762-3p, miR-6769a-3p, miR -6776-3p、miR-6778-3p、miR-6779-3p、miR-678 6-3p, miR-6787-3p, miR-6792-3p, miR-6794-3p miR-6801-3p miR-6802-3p miR-6803-3p miR -6804-3p, miR-6810-5p, miR-6823-3p, miR-682 5-3p, miR-6829-3p, miR-6833-3p, miR-6834-3p miR-6780b-3p miR-6845-3p miR-6862-3p mi R-6865-3p, miR-6870-3p, miR-6875-3p, miR-68 77-3p, miR-6879-3p, miR-6882-3p, miR-6885-3 p, miR-6886-3p, miR-6887-3p, miR-6890-3p, mi R-6893-3p, miR-6894-3p, miR-7106-3p, miR-71 09-3p, miR-7114-3p, miR-7155-5p, miR-7160-5 p, miR-615-3p, miR-920, miR-1825, miR-675-3p , miR-1910-5p, miR-2278, miR-2682-3p, miR-31 22, miR-3151-5p, miR-3175, miR-4323, miR-432 6, miR-4284, miR-3605-3p, miR-3622b-5p, miR- 3646, miR-3158-5p, miR-4722-3p, miR-4728-3p , miR-4747-3p, miR-4436b-5p, miR-5196-3p, mi R-5589-5p, miR-345-3p, miR-642b-5p, miR-671 6-3p, miR-6511b-3p, miR-208a-5p, miR-6726-3 p, miR-6744-5p, miR-6782-3p, miR-6789-3p, mi R-6797-3p, miR-6800-3p, miR-6806-5p, miR-68 24-3p, miR-6837-5p, miR-6846-3p, miR-6858-3 p, miR-6859-3p, miR-6861-3p, miR-6880-3p, mi R-7111-3p, miR-7152-5p, miR-642a-5p, miR-65 7, miR-1236-3p, miR-764, miR-4314, miR-3675- 3p, miR-5703, miR-3191-5p, miR-6511a-3p, miR -6809-3p, miR-6815-5p, miR-6857-3p, miR-687 one or more polynucleotides selected from the group consisting of miR-8-3p, and miR-371a-5p a nucleic acid I capable of specifically binding to a strand of the polynucleotide or a complementary strand of the polynucleotide; Optionally, other dementia markers, such as miR-766-3p and miR-1229-3p , miR-1306-5p, miR-210-5p, miR-198, miR-485- 3p, miR-668-3p, miR-532-3p, miR-877-3p, miR- 1238-3p, miR-3130-5p, miR-4298, miR-4290, mi miR-3943, miR-346, and miR-767-3p The above polynucleotide or a nucleic acid capable of specifically binding to the complementary strand of the polynucleotide I A kit for detecting or predicting dementia, further comprising I. (10) The nucleic acid I is a polynucleotide represented by any one of the following (u) to (y): (u) SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128, 133, 191-194, 212, and 250-37 4 or a base sequence in which u is t a polynucleotide comprising 15 or more consecutive bases, a variant thereof, a derivative thereof, or The fragment, (v) SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128, 133, 191-194, 212, and 250-37 (w) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 3, 8, and 15; , 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 1 A base represented by any one of 28, 133, 191 to 194, 212, and 250 to 374 or a polypeptide consisting of a base sequence complementary to the base sequence in which u is t a nucleotide, its variant, its derivative, or a fragment thereof containing 15 or more consecutive bases , (x) SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128, 133, 191-194, 212, and 250-37 4 or the base sequence in which u is t a polynucleotide comprising a complementary base sequence, and (y) a polynucleotide selected from any one of (u) to (x) under stringent conditions; hybridizing polynucleotides, is a polynucleotide selected from the group consisting of The nucleic acid II is a polynucleotide represented by any one of the following (p) to (t): (p) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide consisting of a base sequence in which u is t, a variant thereof, a derivative thereof, or a fragment thereof containing 5 or more consecutive bases; (q) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 375 to 390; (r) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t, a variant thereof, its derivatives or fragments containing 15 or more consecutive bases; (s) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (t) combining any one of the polynucleotides (p) to (s) under stringent conditions hybridizing polynucleotides, The kit according to (9), wherein the polynucleotide is selected from the group consisting of:

[0034] (11) Dementia markers: miR-4274, miR-4272, and miR-472 8-5p, miR-4443, miR-4506, miR-6773-5p, miR-4 662a-5p, miR-3184-3p, miR-4281, miR-320d, mi R-6729-3p, miR-5192, miR-6853-5p, miR-1234- 3p, miR-1233-3p, miR-4539, miR-3914, miR-473 8-5p, miR-548au-3p, miR-1539, miR-4720-3p, m iR-365b-5p, miR-4486, miR-1227-5p, miR-4667 -5p, miR-6088, miR-6820-5p, miR-4505, miR-54 8q、miR-4658、miR-450a-5p、miR-1260b、miR-36 77-5p, miR-6777-3p, miR-6826-3p, miR-6832-3 p, miR-4725-3p, miR-7161-3p, miR-2277-5p, mi R-7110-3p, miR-4312, miR-4461, miR-6766-5p miR-1266-3p, miR-6729-5p, miR-526b-3p, miR- 519e-5p, miR-512-5p, miR-5088-5p, miR-1909- 3p, miR-6511a-5p, miR-4734, miR-936, miR-124 9-3p, miR-6777-5p, miR-4487, miR-3155a, miR- 563, miR-4741, miR-6788-5p, miR-4433b-5p, mi R-323a-5p, miR-6811-5p, miR-6721-5p, miR-50 04-5p, miR-6509-3p, miR-648, miR-3917, miR-6 087, miR-1470, miR-586, miR-3150a-5p, miR-10 5-3p, miR-7973, miR-1914-5p, miR-4749-3p, mi R-15b-5p, miR-1289, miR-4433a-5p, miR-3666 miR-3186-3p, miR-4725-5p, miR-4488, miR-447 4-3p, miR-6731-3p, miR-4640-3p, miR-202-5p miR-6816-5p, miR-638, miR-6821-5p, miR-1247 -3p、miR-6765-5p、miR-6800-5p、miR-3928-3p、 miR-3940-5p, miR-3960, miR-6775-5p, miR-317 8, miR-1202, miR-6790-5p, miR-4731-3p, miR-2 681-3p, miR-6758-5p, miR-8072, miR-518d-3p miR-3606-3p, miR-4800-5p, miR-1292-3p, miR- 6784-3p, miR-4450, miR-6132, miR-4716-5p, mi R-6860, miR-1268b, miR-378d, miR-4701-5p, mi R-4329, miR-185-3p, miR-552-3p, miR-1273g-5 p、miR-6769b-3p、miR-520a-3p、miR-4524b-5p、 miR-4291, miR-6734-3p, miR-143-5p, miR-939- 3p、miR-6889-3p、miR-6842-3p、miR-4511、miR- 4318, miR-4653-5p, miR-6867-3p, miR-133b, mi R-3196, miR-193b-3p, miR-3162-3p, miR-6819- 3p、miR-1908-3p、miR-6786-5p、miR-3648、miR- 4513, miR-3652, miR-4640-5p, miR-6871-5p, mi R-7845-5p, miR-3138, miR-6884-5p, miR-4653- 3p, miR-636, miR-4652-3p, miR-6823-5p, miR-4 502, miR-7113-5p, miR-8087, miR-7154-3p, miR -5189-5p, miR-1253, miR-518c-5p, miR-7151-5 p, miR-3614-3p, miR-4727-5p, miR-3682-5p, mi R-5090, miR-337-3p, miR-488-5p, miR-100-5p miR-4520-3p, miR-373-3p, miR-6499-5p, miR-3 909, miR-32-5p, miR-302a-3p, miR-4686, miR-4 659a-3p, miR-4287, miR-1301-5p, miR-593-3p miR-517a-3p, miR-517b-3p, miR-142-3p, miR-1 185-2-3p, miR-602, miR-527, miR-518a-5p, miR -4682、miR-28-5p、miR-4252、miR-452-5p、miR- 525-5p, miR-3622a-3p, miR-6813-3p, miR-4769 -3p、miR-5698、miR-1915-3p、miR-1343-5p、miR -6861-5p, miR-6781-5p, miR-4508, miR-6743-5 p, miR-6726-5p, miR-4525, miR-4651, miR-6813 -5p、miR-5787、miR-1290、miR-6075、miR-4758- 5p, miR-4690-5p, miR-762, miR-371a-5p, miR-6 765-3p, miR-6784-5p, miR-6778-5p, miR-6875- 5p, miR-4534, miR-4721, miR-6756-5p, miR-615 -5p, miR-6727-5p, miR-6887-5p, miR-8063, miR -6880-5p, miR-6805-3p, miR-4726-5p, miR-471 0, miR-7111-5p, miR-3619-3p, miR-6795-5p, mi R-1254, miR-1233-5p, miR-6836-3p, miR-6769a -5p, miR-4532, miR-365a-5p, miR-1231, miR-12 28-5p, miR-4430, miR-296-3p, miR-1237-5p, mi R-4466, miR-6789-5p, miR-4632-5p, miR-4745- 5p, miR-4665-5p, miR-6807-5p, miR-7114-5p, m iR-516a-5p, miR-769-3p, miR-3692-5p, miR-39 45, miR-4433a-3p, miR-4485-3p, miR-6831-5p, miR-519c-5p, miR-551b-5p, miR-1343-3p, miR- 4286, miR-4634, miR-4733-3p, and miR-6086 Specific to one or more polynucleotides selected from the group, or the complementary strand of said polynucleotides A device for detecting dementia, comprising a nucleic acid capable of binding to (12) The nucleic acid is a polynucleotide represented by any one of the following (a) to (e): (a) any of SEQ ID NOs: 1 to 210, 374, 1315 to 1350, and 1435 to 1448 or a base sequence in which u is t in the base sequence A polynucleotide, its variant, derivative, or fragment containing 15 or more consecutive bases piece, (b) any of SEQ ID NOs: 1 to 210, 374, 1315 to 1350, and 1435 to 1448 A polynucleotide comprising a base sequence represented by any one of (c) SEQ ID NOs: 1 to 210, 374, 1315 to 1350, and 1435 to 1448 Complementary to the base sequence represented by either or the base sequence in which u is t a polynucleotide consisting of a base sequence identical to that of the nucleotide sequence of the present invention, a variant thereof, a derivative thereof, or a polynucleotide consisting of 15 or more consecutive bases a fragment thereof containing the base, (d) SEQ ID NOs: 1 to 210, 374, 1315 to 1350, and 1435 to 1448 Complementary to the base sequence represented by either or the base sequence in which u is t a polynucleotide containing a base sequence such as (e) combining any one of the polynucleotides (a) to (d) under stringent conditions hybridizing polynucleotides, The device according to (11), wherein the polynucleotide is selected from the group consisting of: (13) The device is configured to detect another dementia marker, miR-1225-3p, miR -3184-5p, miR-665, miR-211-5p, miR-1247-5p, miR-3656, miR-149-5p, miR-744-5p, miR-345-5 p, miR-150-5p, miR-191-3p, miR-651-5p, miR-3 4a-5p, miR-409-5p, miR-369-5p, miR-1915-5p, miR-204-5p, miR-137, miR-382-5p, miR-517-5p , miR-532-5p, miR-22-5p, miR-1237-3p, miR-12 24-3p, miR-625-3p, miR-328-3p, miR-122-5p, m iR-202-3p, miR-4781-5p, miR-718, miR-342-3p , miR-26b-3p, miR-140-3p, miR-200a-3p, miR-3 78a-3p, miR-484, miR-296-5p, miR-205-5p, miR -431-5p, miR-150-3p, miR-423-5p, miR-575, mi R-671-5p, miR-939-5p, miR-3665, miR-30d-5p, miR-30b-3p, miR-92a-3p, miR-371b-5p, and miR- 486-5p, or one or more polynucleotides selected from the group consisting of The method according to (11) or (12), further comprising a nucleic acid capable of specifically binding to a complementary strand of the nucleic acid. Vice. (14) The nucleic acid is a polynucleotide represented by any one of the following (f) to (j): (f) any of SEQ ID NOs: 211 to 249, 1351 to 1356, and 1449 to 1453 or a polynucleotide sequence in which u is t in the base sequence a nucleotide, a variant thereof, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases; (g) any of SEQ ID NOs: 211 to 249, 1351 to 1356, and 1449 to 1453 A polynucleotide comprising a base sequence represented by (h) any of SEQ ID NOs: 211 to 249, 1351 to 1356, and 1449 to 1453 or a base complementary to the base sequence in which u is t in the base sequence A polynucleotide consisting of a sequence, its variant, its derivative, or 15 or more consecutive bases The fragment containing (i) any of SEQ ID NOs: 211 to 249, 1351 to 1356, and 1449 to 1453 A base sequence complementary to the base sequence represented by the above or the base sequence in which u is t a polynucleotide comprising the base sequence, and (j) combining the polynucleotide of any one of (f) to (i) under stringent conditions hybridizing polynucleotides, The device according to (13), wherein the polynucleotide is selected from the group consisting of:

[0035] (15) The device is capable of detecting other dementia markers, such as miR-1471 and miR-15 38, miR-449b-3p, miR-1976, miR-4268, miR-427 9, miR-3620-3p, miR-3944-3p, miR-3156-3p, mi R-3187-5p, miR-4685-3p, miR-4695-3p, miR-46 97-3p, miR-4713-5p, miR-4723-3p, miR-371b-3 p, miR-3151-3p, miR-3192-3p, miR-6728-3p, mi R-6736-3p, miR-6740-3p, miR-6741-3p, miR-67 43-3p, miR-6747-3p, miR-6750-3p, miR-6754-3 p, miR-6759-3p, miR-6761-3p, miR-6762-3p, mi R-6769a-3p, miR-6776-3p, miR-6778-3p, miR-6 779-3p, miR-6786-3p, miR-6787-3p, miR-6792- 3p, miR-6794-3p, miR-6801-3p, miR-6802-3p, m iR-6803-3p, miR-6804-3p, miR-6810-5p, miR-6 823-3p, miR-6825-3p, miR-6829-3p, miR-6833- 3p, miR-6834-3p, miR-6780b-3p, miR-6845-3p miR-6862-3p, miR-6865-3p, miR-6870-3p, miR- 6875-3p, miR-6877-3p, miR-6879-3p, miR-6882 -3p、miR-6885-3p、miR-6886-3p、miR-6887-3p、 miR-6890-3p, miR-6893-3p, miR-6894-3p, miR- 7106-3p, miR-7109-3p, miR-7114-3p, miR-7155 -5p, miR-7160-5p, miR-615-3p, miR-920, miR-1 825, miR-675-3p, miR-1910-5p, miR-2278, miR- 2682-3p, miR-3122, miR-3151-5p, miR-3175, mi R-4323, miR-4326, miR-4284, miR-3605-3p, miR -3622b-5p、miR-3646、miR-3158-5p、miR-4722- 3p、miR-4728-3p、miR-4747-3p、miR-4436b-5p、 miR-5196-3p, miR-5589-5p, miR-345-3p, miR-6 42b-5p, miR-6716-3p, miR-6511b-3p, miR-208a -5p、miR-6726-3p、miR-6744-5p、miR-6782-3p、 miR-6789-3p, miR-6797-3p, miR-6800-3p, miR- 6806-5p, miR-6824-3p, miR-6837-5p, miR-6846 -3p, miR-6858-3p, miR-6859-3p, miR-6861-3p, miR-6880-3p, miR-7111-3p, miR-7152-5p, miR- 642a-5p, miR-657, miR-1236-3p, miR-764, miR- 4314, miR-3675-3p, miR-5703, miR-3191-5p, mi R-6511a-3p, miR-6809-3p, miR-6815-5p, miR-6 one or more polynucleotides selected from the group consisting of miR-857-3p, and miR-6878-3p The polynucleotide further comprises a nucleic acid capable of specifically binding to a complementary strand of the polynucleotide, The device according to any one of 11) to 14). (16) The nucleic acid is a polynucleotide represented by any one of the following (k) to (o): (k) a base sequence represented by any one of SEQ ID NOs: 250 to 373 or the base sequence a polynucleotide consisting of a base sequence in which u is t, a variant thereof, a derivative thereof, or a fragment thereof containing 5 or more consecutive bases; (l) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 250 to 373; (m) a base sequence represented by any one of SEQ ID NOs: 250 to 373 or the base sequence a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t, a variant thereof, its derivatives or fragments containing 15 or more consecutive bases; (n) a base sequence represented by any one of SEQ ID NOs: 250 to 373 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (o) combining any one of the polynucleotides (k) to (n) under stringent conditions hybridizing polynucleotides, The device according to (15), wherein the polynucleotide is selected from the group consisting of: (17) The device is capable of detecting another dementia marker, miR-766-3p, miR- 1229-3p, miR-1306-5p, miR-210-5p, miR-198, m iR-485-3p, miR-668-3p, miR-532-3p, miR-877- 3p, miR-1238-3p, miR-3130-5p, miR-4298, miR- From the group consisting of 4290, miR-3943, miR-346, and miR-767-3p or a complementary strand of the polynucleotide. The device according to any one of (11) to (16), further comprising a nucleic acid capable of binding. (18) The nucleic acid is a polynucleotide represented by any one of the following (p) to (t): (p) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide consisting of a base sequence in which u is t, a variant thereof, a derivative thereof, or a fragment thereof containing 5 or more consecutive bases; (q) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 375 to 390; (r) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t, a variant thereof, its derivatives or fragments containing 15 or more consecutive bases; (s) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (t) combining any one of the polynucleotides (p) to (s) under stringent conditions hybridizing polynucleotides, The device according to (17), which is a polynucleotide selected from the group consisting of

[0036] (19) miR-4728-5p, miR-3184-3p, m iR-1233-3p, miR-6088, miR-6777-3p, miR-7110 -3p, miR-936, miR-6087, miR-1202, miR-4731-3 p, miR-4800-5p, miR-6784-3p, miR-4716-5p, mi R-6734-3p, miR-6889-3p, miR-6867-3p, miR-36 22a-3p, miR-6813-3p, miR-4769-3p, miR-5698, miR-3184-5p, miR-1471, miR-1538, miR-449b-3 p, miR-1976, miR-4268, miR-4279, miR-3620-3p , miR-3944-3p, miR-3156-3p, miR-3187-5p, miR -4685-3p, miR-4695-3p, miR-4697-3p, miR-471 3-5p, miR-4723-3p, miR-371b-3p, miR-3151-3p , miR-3192-3p, miR-6728-3p, miR-6736-3p, miR -6740-3p, miR-6741-3p, miR-6743-3p, miR-674 7-3p, miR-6750-3p, miR-6754-3p, miR-6759-3p , miR-6761-3p, miR-6762-3p, miR-6769a-3p, mi R-6776-3p, miR-6778-3p, miR-6779-3p, miR-67 86-3p, miR-6787-3p, miR-6792-3p, miR-6794-3 p, miR-6801-3p, miR-6802-3p, miR-6803-3p, mi R-6804-3p, miR-6810-5p, miR-6823-3p, miR-68 25-3p, miR-6829-3p, miR-6833-3p, miR-6834-3 p, miR-6780b-3p, miR-6845-3p, miR-6862-3p, m iR-6865-3p, miR-6870-3p, miR-6875-3p, miR-6 877-3p, miR-6879-3p, miR-6882-3p, miR-6885- 3p, miR-6886-3p, miR-6887-3p, miR-6890-3p, m iR-6893-3p, miR-6894-3p, miR-7106-3p, miR-7 109-3p, miR-7114-3p, miR-7155-5p, miR-7160- 5p, miR-615-3p, miR-920, miR-1825, miR-675-3 p, miR-1910-5p, miR-2278, miR-2682-3p, miR-3 122、miR-3151-5p、miR-3175、miR-4323、miR-43 26、miR-4284、miR-3605-3p、miR-3622b-5p、miR -3646, miR-3158-5p, miR-4722-3p, miR-4728-3 p, miR-4747-3p, miR-4436b-5p, miR-5196-3p, m iR-5589-5p, miR-345-3p, miR-642b-5p, miR-67 16-3p, miR-6511b-3p, miR-208a-5p, miR-6726- 3p, miR-6744-5p, miR-6782-3p, miR-6789-3p, m iR-6797-3p, miR-6800-3p, miR-6806-5p, miR-6 824-3p, miR-6837-5p, miR-6846-3p, miR-6858- 3p, miR-6859-3p, miR-6861-3p, miR-6880-3p, m iR-7111-3p, miR-7152-5p, miR-642a-5p, miR-6 57, miR-1236-3p, miR-764, miR-4314, miR-3675 -3p, miR-5703, miR-3191-5p, miR-6511a-3p, mi R-6809-3p, miR-6815-5p, miR-6857-3p, miR-68 one or more polynucleotides selected from the group consisting of miR-78-3p, and miR-371a-5p a nucleic acid I capable of specifically binding to a complementary strand of the polynucleotide, Optionally, other dementia markers, such as miR-766-3p and miR-1229-3p , miR-1306-5p, miR-210-5p, miR-198, miR-485- 3p, miR-668-3p, miR-532-3p, miR-877-3p, miR- 1238-3p, miR-3130-5p, miR-4298, miR-4290, mi miR-3943, miR-346, and miR-767-3p The above polynucleotide or a nucleic acid capable of specifically binding to the complementary strand of the polynucleotide I A device for detecting or predicting dementia, further comprising I. (20) The nucleic acid I is a polynucleotide represented by any one of the following (u) to (y): (u) SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128, 133, 191-194, 212, and 250-37 4 or a base sequence in which u is t a polynucleotide comprising 15 or more consecutive bases, a variant thereof, a derivative thereof, or The fragment, (v) SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128, 133, 191-194, 212, and 250-37 (w) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 3, 8, and 15; , 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 1 A base represented by any one of 28, 133, 191 to 194, 212, and 250 to 374 or a polypeptide consisting of a base sequence complementary to the base sequence in which u is t a nucleotide, its variant, its derivative, or a fragment thereof containing 15 or more consecutive bases , (x) SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128, 133, 191-194, 212, and 250-37 4 or the base sequence in which u is t a polynucleotide comprising a complementary base sequence, and (y) a polynucleotide selected from any one of (u) to (x) under stringent conditions; hybridizing polynucleotides, is a polynucleotide selected from the group consisting of The nucleic acid II is a polynucleotide represented by any one of the following (p) to (t): (p) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide consisting of a base sequence in which u is t, a variant thereof, a derivative thereof, or a fragment thereof containing 5 or more consecutive bases; (q) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 375 to 390; (r) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t, a variant thereof, its derivatives or fragments containing 15 or more consecutive bases; (s) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (t) combining any one of the polynucleotides (p) to (s) under stringent conditions hybridizing polynucleotides, The device according to (19), wherein the polynucleotide is selected from the group consisting of: (21) The device is a device for measurement by hybridization technology. The device according to any one of (11) to (20). (22) The method according to (21), wherein the hybridization technique is a nucleic acid array technique. device.

[0037] (23) In the subject's samples, the dementia markers miR-4274 and miR-4 272, miR-4728-5p, miR-4443, miR-4506, miR-67 73-5p, miR-4662a-5p, miR-3184-3p, miR-4281, miR-320d, miR-6729-3p, miR-5192, miR-6853-5 p, miR-1234-3p, miR-1233-3p, miR-4539, miR-3 914, miR-4738-5p, miR-548au-3p, miR-1539, mi R-4720-3p, miR-365b-5p, miR-4486, miR-1227- 5p, miR-4667-5p, miR-6088, miR-6820-5p, miR- 4505, miR-548q, miR-4658, miR-450a-5p, miR-1 260b, miR-3677-5p, miR-6777-3p, miR-6826-3p miR-6832-3p miR-4725-3p miR-7161-3p miR -2277-5p、miR-7110-3p、miR-4312、miR-4461、m iR-6766-5p, miR-1266-3p, miR-6729-5p, miR-5 26b-3p, miR-519e-5p, miR-512-5p, miR-5088-5 p、miR-1909-3p、miR-6511a-5p、miR-4734、miR- 936、miR-1249-3p、miR-6777-5p、miR-4487、miR -3155a, miR-563, miR-4741, miR-6788-5p, miR- 4433b-5p, miR-323a-5p, miR-6811-5p, miR-672 1-5p, miR-5004-5p, miR-6509-3p, miR-648, miR -3917, miR-6087, miR-1470, miR-586, miR-3150 a-5p, miR-105-3p, miR-7973, miR-1914-5p, miR -4749-3p, miR-15b-5p, miR-1289, miR-4433a-5 p, miR-3666, miR-3186-3p, miR-4725-5p, miR-4 488, miR-4474-3p, miR-6731-3p, miR-4640-3p miR-202-5p, miR-6816-5p, miR-638, miR-6821- 5p, miR-1247-3p, miR-6765-5p, miR-6800-5p, m iR-3928-3p, miR-3940-5p, miR-3960, miR-6775 -5p, miR-3178, miR-1202, miR-6790-5p, miR-47 31-3p, miR-2681-3p, miR-6758-5p, miR-8072, m iR-518d-3p, miR-3606-3p, miR-4800-5p, miR-1 292-3p, miR-6784-3p, miR-4450, miR-6132, miR -4716-5p, miR-6860, miR-1268b, miR-378d, miR -4701-5p, miR-4329, miR-185-3p, miR-552-3p miR-1273g-5p, miR-6769b-3p, miR-520a-3p, mi R-4524b-5p, miR-4291, miR-6734-3p, miR-143- 5p, miR-939-3p, miR-6889-3p, miR-6842-3p, mi R-4511, miR-4318, miR-4653-5p, miR-6867-3p miR-133b, miR-3196, miR-193b-3p, miR-3162-3 p, miR-6819-3p, miR-1908-3p, miR-6786-5p, mi R-3648, miR-4513, miR-3652, miR-4640-5p, miR -6871-5p, miR-7845-5p, miR-3138, miR-6884-5 p, miR-4653-3p, miR-636, miR-4652-3p, miR-68 23-5p, miR-4502, miR-7113-5p, miR-8087, miR- 7154-3p, miR-5189-5p, miR-1253, miR-518c-5p miR-7151-5p miR-3614-3p miR-4727-5p miR -3682-5p、miR-5090、miR-337-3p、miR-488-5p、 miR-100-5p, miR-4520-3p, miR-373-3p, miR-64 99-5p, miR-3909, miR-32-5p, miR-302a-3p, miR -4686、miR-4659a-3p、miR-4287、miR-1301-5p、 miR-593-3p, miR-517a-3p, miR-517b-3p, miR-1 42-3p、miR-1185-2-3p、miR-602、miR-527、miR- 518a-5p, miR-4682, miR-28-5p, miR-4252, miR- 452-5p, miR-525-5p, miR-3622a-3p, miR-6813- 3p、miR-4769-3p、miR-5698、miR-1915-3p、miR- 1343-5p, miR-6861-5p, miR-6781-5p, miR-4508 miR-6743-5p miR-6726-5p miR-4525 miR-46 51, miR-6813-5p, miR-5787, miR-1290, miR-607 5, miR-4758-5p, miR-4690-5p, miR-762, miR-37 1a-5p, miR-6765-3p, miR-6784-5p, miR-6778-5 p, miR-6875-5p, miR-4534, miR-4721, miR-6756 -5p, miR-615-5p, miR-6727-5p, miR-6887-5p, m iR-8063, miR-6880-5p, miR-6805-3p, miR-4726 -5p, miR-4710, miR-7111-5p, miR-3619-3p, miR -6795-5p, miR-1254, miR-1233-5p, miR-6836-3 p, miR-6769a-5p, miR-4532, miR-365a-5p, miR- 1231, miR-1228-5p, miR-4430, miR-296-3p, miR -1237-5p, miR-4466, miR-6789-5p, miR-4632-5 p, miR-4745-5p, miR-4665-5p, miR-6807-5p, mi R-7114-5p, miR-516a-5p, miR-769-3p, miR-369 2-5p, miR-3945, miR-4433a-3p, miR-4485-3p, m iR-6831-5p, miR-519c-5p, miR-551b-5p, miR-1 343-3p, miR-4286, miR-4634, miR-4733-3p, and m measuring the expression level of one or more polynucleotides selected from the group consisting of iR-6086; The measured expression level is used to determine whether or not a subject suffers from dementia in vitro. 10. A method for detecting dementia, comprising assessing (24) Gene expression levels of samples from subjects known to have dementia and non-dementia subjects The gene expression levels of samples derived from the body were used as teacher samples, and the subjects were either dementia or non-dementia. a discriminant that can distinguish between the one or more Substituting the expression level of polynucleotides to evaluate dementia or non-dementia. The method according to (23), comprising: (25) A nucleic acid capable of specifically binding to the polynucleotide or a complementary strand of the polynucleotide. The expression level of the polynucleotide is measured using an acid, and the nucleic acid is determined to be one of the following (a) to (b): e) a polynucleotide as defined in any one of: (a) any of SEQ ID NOs: 1 to 210, 374, 1315 to 1350, and 1435 to 1448 A base sequence represented by either of the above, or a base sequence in which u is t in the base sequence, a polynucleotide comprising 15 or more consecutive bases, a variant thereof, a derivative thereof, or a polynucleotide comprising 15 or more consecutive bases Fragments of, (b) any of SEQ ID NOs: 1 to 210, 374, 1315 to 1350, and 1435 to 1448 A polynucleotide comprising a base sequence represented by any one of (c) SEQ ID NOs: 1 to 210, 374, 1315 to 1350, and 1435 to 1448 or a base sequence in which u is t in the base sequence. A polynucleotide consisting of a complementary base sequence, its variant, its derivative, or a sequence of 15 or more a fragment thereof containing the following bases, (d) SEQ ID NOs: 1 to 210, 374, 1315 to 1350, and 1435 to 1448 or a base sequence in which u is t in the base sequence. a polynucleotide comprising the complementary base sequence, and (e) combining any one of the polynucleotides (a) to (d) under stringent conditions hybridizing polynucleotides, The method according to (23) or (24), wherein the polynucleotide is selected from the group consisting of .

[0038] (26) miR-1225-3p and miR-3184-5p, which are other dementia markers , miR-665, miR-211-5p, miR-1247-5p, miR-3656 , miR-149-5p, miR-744-5p, miR-345-5p, miR-15 0-5p, miR-191-3p, miR-651-5p, miR-34a-5p, mi R-409-5p, miR-369-5p, miR-1915-5p, miR-204- 5p, miR-137, miR-382-5p, miR-517-5p, miR-532 -5p, miR-22-5p, miR-1237-3p, miR-1224-3p, mi R-625-3p, miR-328-3p, miR-122-5p, miR-202-3 p, miR-4781-5p, miR-718, miR-342-3p, miR-26b -3p, miR-140-3p, miR-200a-3p, miR-378a-3p, m iR-484, miR-296-5p, miR-205-5p, miR-431-5p, miR-150-3p, miR-423-5p, miR-575, miR-671-5p , miR-939-5p, miR-3665, miR-30d-5p, miR-30b- 3p, miR-92a-3p, miR-371b-5p, and miR-486-5p Further comprising measuring the expression level of one or more polynucleotides selected from the group consisting of: The method according to any one of (23) to (25). (27) A nucleic acid capable of specifically binding to the polynucleotide or a complementary strand of the polynucleotide. The expression level of the polynucleotide is measured using an acid, and the nucleic acid is determined to be one of the following (f) to ( j) a polynucleotide as defined in any one of: (f) any of SEQ ID NOs: 211 to 249, 1351 to 1356, and 1449 to 1453 or a base sequence in which u is t in the base sequence A polynucleotide, its variant, derivative, or fragment containing 15 or more consecutive bases piece, (g) any of SEQ ID NOs: 211 to 249, 1351 to 1356, and 1449 to 1453 A polynucleotide comprising a base sequence represented by (h) any of SEQ ID NOs: 211 to 249, 1351 to 1356, and 1449 to 1453 or a base sequence in which u is t in the base sequence, a polynucleotide consisting of a base sequence identical to that of the nucleotide sequence of the present invention, a variant thereof, a derivative thereof, or a polynucleotide consisting of 15 or more consecutive bases a fragment thereof containing the base, (i) any of SEQ ID NOs: 211 to 249, 1351 to 1356, and 1449 to 1453 or a base sequence in which u is t in the base sequence, a polynucleotide containing a base sequence such as (j) combining the polynucleotide of any one of (f) to (i) under stringent conditions hybridizing polynucleotides, The method according to (26), wherein the polynucleotide is selected from the group consisting of: (28) miR-1471, miR-1538, and miR-4, which are other dementia markers. 49b-3p, miR-1976, miR-4268, miR-4279, miR-36 20-3p, miR-3944-3p, miR-3156-3p, miR-3187-5 p, miR-4685-3p, miR-4695-3p, miR-4697-3p, mi R-4713-5p, miR-4723-3p, miR-371b-3p, miR-31 51-3p, miR-3192-3p, miR-6728-3p, miR-6736-3 p, miR-6740-3p, miR-6741-3p, miR-6743-3p, mi R-6747-3p, miR-6750-3p, miR-6754-3p, miR-67 59-3p, miR-6761-3p, miR-6762-3p, miR-6769a- 3p, miR-6776-3p, miR-6778-3p, miR-6779-3p, m iR-6786-3p, miR-6787-3p, miR-6792-3p, miR-6 794-3p, miR-6801-3p, miR-6802-3p, miR-6803- 3p, miR-6804-3p, miR-6810-5p, miR-6823-3p, m iR-6825-3p, miR-6829-3p, miR-6833-3p, miR-6 834-3p, miR-6780b-3p, miR-6845-3p, miR-6862 -3p、miR-6865-3p、miR-6870-3p、miR-6875-3p、 miR-6877-3p, miR-6879-3p, miR-6882-3p, miR- 6885-3p, miR-6886-3p, miR-6887-3p, miR-6890 -3p、miR-6893-3p、miR-6894-3p、miR-7106-3p、 miR-7109-3p, miR-7114-3p, miR-7155-5p, miR- 7160-5p, miR-615-3p, miR-920, miR-1825, miR- 675-3p、miR-1910-5p、miR-2278、miR-2682-3p、 miR-3122, miR-3151-5p, miR-3175, miR-4323, m iR-4326, miR-4284, miR-3605-3p, miR-3622b-5 p, miR-3646, miR-3158-5p, miR-4722-3p, miR-4 728-3p, miR-4747-3p, miR-4436b-5p, miR-5196 -3p, miR-5589-5p, miR-345-3p, miR-642b-5p, m iR-6716-3p, miR-6511b-3p, miR-208a-5p, miR- 6726-3p, miR-6744-5p, miR-6782-3p, miR-6789 -3p, miR-6797-3p, miR-6800-3p, miR-6806-5p, miR-6824-3p, miR-6837-5p, miR-6846-3p, miR- 6858-3p, miR-6859-3p, miR-6861-3p, miR-6880 -3p, miR-7111-3p, miR-7152-5p, miR-642a-5p, miR-657, miR-1236-3p, miR-764, miR-4314, miR -3675-3p, miR-5703, miR-3191-5p, miR-6511a- 3p, miR-6809-3p, miR-6815-5p, miR-6857-3p, and and miR-6878-3p. The method according to any one of (23) to (27), further comprising measuring: (29) A nucleic acid capable of specifically binding to the polynucleotide or a complementary strand of the polynucleotide. The expression level of the polynucleotide is measured using an acid, and the nucleic acid is selected from the following (k) to ( o) a polynucleotide as defined in any one of: (k) a base sequence represented by any one of SEQ ID NOs: 250 to 373 or the base sequence a polynucleotide consisting of a base sequence in which u is t, a variant thereof, a derivative thereof, or a fragment thereof containing 5 or more consecutive bases; (l) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 250 to 373; (m) a base sequence represented by any one of SEQ ID NOs: 250 to 373 or the base sequence a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t, a variant thereof, its derivatives or fragments containing 15 or more consecutive bases; (n) a base sequence represented by any one of SEQ ID NOs: 250 to 373 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (o) combining any one of the polynucleotides (k) to (n) under stringent conditions hybridizing polynucleotides, The device according to (28), wherein the polynucleotide is selected from the group consisting of: (30) miR-766-3p, miR-1229-3p, another dementia marker, miR-1306-5p, miR-210-5p, miR-198, miR-485-3 p, miR-668-3p, miR-532-3p, miR-877-3p, miR-1 238-3p, miR-3130-5p, miR-4298, miR-4290, miR one or more selected from the group consisting of miR-3943, miR-346, and miR-767-3p Any of (23) to (29) further comprising measuring the expression level of the polynucleotide. The method described below.

[0039] (31) A nucleic acid capable of specifically binding to the polynucleotide or a complementary strand of the polynucleotide. The expression level of the polynucleotide is measured using an acid, and the nucleic acid is determined to be one of the following (p) to ( t) a polynucleotide as set forth in any one of: (p) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide consisting of a base sequence in which u is t, a variant thereof, a derivative thereof, or a fragment thereof containing 5 or more consecutive bases; (q) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 375 to 390; (r) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t, a variant thereof, its derivatives or fragments containing 15 or more consecutive bases; (s) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (t) combining any one of the polynucleotides (p) to (s) under stringent conditions hybridizing polynucleotides, The method according to (30), wherein the polynucleotide is selected from the group consisting of: (32) miR-4728-5p, miR-3184-3p, and miR-m iR-1233-3p, miR-6088, miR-6777-3p, miR-7110 -3p, miR-936, miR-6087, miR-1202, miR-4731-3 p, miR-4800-5p, miR-6784-3p, miR-4716-5p, mi R-6734-3p, miR-6889-3p, miR-6867-3p, miR-36 22a-3p, miR-6813-3p, miR-4769-3p, miR-5698, miR-3184-5p, miR-1471, miR-1538, miR-449b-3 p, miR-1976, miR-4268, miR-4279, miR-3620-3p , miR-3944-3p, miR-3156-3p, miR-3187-5p, miR -4685-3p, miR-4695-3p, miR-4697-3p, miR-471 3-5p, miR-4723-3p, miR-371b-3p, miR-3151-3p , miR-3192-3p, miR-6728-3p, miR-6736-3p, miR -6740-3p, miR-6741-3p, miR-6743-3p, miR-674 7-3p, miR-6750-3p, miR-6754-3p, miR-6759-3p miR-6761-3p miR-6762-3p miR-6769a-3p mi R-6776-3p, miR-6778-3p, miR-6779-3p, miR-67 86-3p, miR-6787-3p, miR-6792-3p, miR-6794-3 p, miR-6801-3p, miR-6802-3p, miR-6803-3p, mi R-6804-3p, miR-6810-5p, miR-6823-3p, miR-68 25-3p, miR-6829-3p, miR-6833-3p, miR-6834-3 p, miR-6780b-3p, miR-6845-3p, miR-6862-3p, m iR-6865-3p, miR-6870-3p, miR-6875-3p, miR-6 877-3p, miR-6879-3p, miR-6882-3p, miR-6885- 3p, miR-6886-3p, miR-6887-3p, miR-6890-3p, m iR-6893-3p, miR-6894-3p, miR-7106-3p, miR-7 109-3p, miR-7114-3p, miR-7155-5p, miR-7160- 5p, miR-615-3p, miR-920, miR-1825, miR-675-3 p, miR-1910-5p, miR-2278, miR-2682-3p, miR-3 122、miR-3151-5p、miR-3175、miR-4323、miR-43 26、miR-4284、miR-3605-3p、miR-3622b-5p、miR -3646, miR-3158-5p, miR-4722-3p, miR-4728-3 p, miR-4747-3p, miR-4436b-5p, miR-5196-3p, m iR-5589-5p, miR-345-3p, miR-642b-5p, miR-67 16-3p, miR-6511b-3p, miR-208a-5p, miR-6726- 3p, miR-6744-5p, miR-6782-3p, miR-6789-3p, m iR-6797-3p, miR-6800-3p, miR-6806-5p, miR-6 824-3p, miR-6837-5p, miR-6846-3p, miR-6858- 3p, miR-6859-3p, miR-6861-3p, miR-6880-3p, m iR-7111-3p, miR-7152-5p, miR-642a-5p, miR-6 57, miR-1236-3p, miR-764, miR-4314, miR-3675 -3p, miR-5703, miR-3191-5p, miR-6511a-3p, mi R-6809-3p, miR-6815-5p, miR-6857-3p, miR-68 one or more polynucleotides selected from the group consisting of miR-78-3p, and miR-371a-5p measuring the expression level of otide I; Optionally, other dementia markers, such as miR-766-3p and miR-1229-3p , miR-1306-5p, miR-210-5p, miR-198, miR-485- 3p, miR-668-3p, miR-532-3p, miR-877-3p, miR- 1238-3p, miR-3130-5p, miR-4298, miR-4290, mi miR-3943, miR-346, and miR-767-3p The method further comprises measuring the expression level of the above polynucleotide II, The measured expression level is used to determine whether or not a subject suffers from dementia in vitro. or to predict in vitro the likelihood that a subject will suffer from dementia. A method for detecting or predicting dementia, comprising: (33) A nucleic acid capable of specifically binding to the polynucleotide I or a complementary strand of the polynucleotide I. The expression level of the polynucleotide I is measured using a nucleic acid, and the nucleic acid is found to be A polynucleotide shown in any one of (y) to (y): (u) SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128, 133, 191-194, 212, and 250-37 4 or a base sequence in which u is t a polynucleotide comprising 15 or more consecutive bases, a variant thereof, a derivative thereof, or The fragment, (v) SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128, 133, 191-194, 212, and 250-37 (w) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 3, 8, and 15; , 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 1 A base represented by any one of 28, 133, 191 to 194, 212, and 250 to 374 or a polypeptide consisting of a base sequence complementary to the base sequence in which u is t a nucleotide, its variant, its derivative, or a fragment thereof containing 15 or more consecutive bases , (x) SEQ ID NOs: 3, 8, 15, 26, 34, 40, 53, 69, 99, 101, 107, 109, 112, 125, 128, 133, 191-194, 212, and 250-37 4 or the base sequence in which u is t a polynucleotide comprising a complementary base sequence, and (y) a polynucleotide selected from any one of (u) to (x) under stringent conditions; hybridizing polynucleotides, is a polynucleotide selected from the group consisting of a nucleic acid capable of specifically binding to the polynucleotide II or a complementary strand of the polynucleotide; The expression level of the polynucleotide II is measured using the following (p) to ( t) a polynucleotide as set forth in any one of: (p) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide consisting of a base sequence in which u is t, a variant thereof, a derivative thereof, or a fragment thereof containing 5 or more consecutive bases; (q) a polynucleotide comprising a nucleotide sequence represented by any one of SEQ ID NOs: 375 to 390; (r) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t, a variant thereof, its derivatives or fragments containing 15 or more consecutive bases; (s) a base sequence represented by any one of SEQ ID NOs: 375 to 390 or the base sequence a polynucleotide comprising a base sequence complementary to the base sequence in which u is t; (t) combining any one of the polynucleotides (p) to (s) under stringent conditions hybridizing polynucleotides, The method according to (32), wherein the polynucleotide is selected from the group consisting of: (34) The kit according to any one of (1) to (10) or (11) to (22). The expression level of a target gene in a sample of a subject is measured using the device described in (2). The method according to any one of 3) to (33). (35) The method according to any one of (23) to (34), wherein the subject is a human.

[0040] (36) The sample according to any one of (23) to (35), wherein the sample is blood, serum, or plasma. How to do it. (1') Dementia markers, miR-5698, miR-1915-3p, and miR- 1343-5p, miR-6861-5p, miR-6781-5p, miR-4508 , miR-6743-5p, miR-6726-5p, miR-4525, miR-46 51, miR-6813-5p, miR-5787, miR-1290, miR-607 5, miR-4758-5p, miR-4690-5p, miR-762, miR-37 1a-5p, miR-6765-3p, miR-6784-5p, miR-6778-5 p, miR-6875-5p, miR-4534, miR-4721, miR-6756 -5p, miR-615-5p, miR-6727-5p, miR-6887-5p, m iR-8063, miR-6880-5p, miR-6805-3p, miR-4726 -5p, miR-4710, miR-7111-5p, miR-3619-3p, miR -6795-5p, miR-1254, miR-1233-5p, miR-6836-3 p, miR-6769a-5p, miR-4532, miR-365a-5p, miR- 1231, miR-1228-5p, miR-4430, miR-296-3p, miR -1237-5p, miR-4466, miR-6789-5p, miR-4632-5 p, miR-4745-5p, miR-4665-5p, miR-6807-5p, and miR-7114-5p A kit for detecting dementia, comprising a nucleic acid capable of binding. (2') The nucleic acid is a polynucleotide represented by any one of the following (a) to (e): (a) SEQ ID NOs: 194 to 210, 374, and 1315 to 1350 A polynucleotide consisting of a base sequence or a base sequence in which u is t , a variant thereof, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases, (b) SEQ ID NOs: 194 to 210, 374, and 1315 to 1350 a polynucleotide comprising a base sequence; (c) SEQ ID NOs: 194 to 210, 374, and 1315 to 1350 A base sequence that is complementary to a base sequence in which u is replaced by t. a polynucleotide containing 15 or more consecutive bases, a variant thereof, a derivative thereof, or a sequence thereof containing 15 or more consecutive bases piece, (d) SEQ ID NOs: 194 to 210, 374, and 1315 to 1350 Contains a base sequence or a base sequence complementary to the base sequence in which u is replaced by t polynucleotides, and (e) combining any one of the polynucleotides (a) to (d) under stringent conditions hybridizing polynucleotides, The kit according to (1'), wherein the polynucleotide is selected from the group consisting of: (3') The kit further comprises a diagnostic kit for detecting another dementia marker, miR-1225-3p, miR- 3184-5p, miR-150-3p, miR-423-5p, miR-575, mi miR-671-5p, miR-939-5p, and miR-3665 (1') or ( 2') A kit according to the above. (4') The nucleic acid is a polynucleotide represented by any one of the following (f) to (j): (f) a nucleotide sequence represented by any one of SEQ ID NOs: 211 to 212 and 1351 to 1356 Or a polynucleotide consisting of a base sequence in which u is t in the base sequence, or a variant thereof variants, derivatives thereof, or fragments thereof containing 15 or more consecutive bases; (g) a nucleotide sequence represented by any one of SEQ ID NOs: 211 to 212 and 1351 to 1356 a polynucleotide comprising (h) a nucleotide sequence represented by any one of SEQ ID NOs: 211 to 212 and 1351 to 1356 Or a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t in the base sequence. a nucleotide, a variant thereof, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases; (i) a nucleotide sequence represented by any one of SEQ ID NOs: 211 to 212 and 1351 to 1356 Or a polynucleotide containing a base sequence complementary to the base sequence in which u is t in the base sequence. Reotide, and (j) combining the polynucleotide of any one of (f) to (i) under stringent conditions hybridizing polynucleotides, The kit according to (3'), wherein the polynucleotide is selected from the group consisting of: (5') Dementia markers, miR-5698, miR-1915-3p, miR- 1343-5p, miR-6861-5p, miR-6781-5p, miR-4508 , miR-6743-5p, miR-6726-5p, miR-4525, miR-46 51, miR-6813-5p, miR-5787, miR-1290, miR-607 5, miR-4758-5p, miR-4690-5p, miR-762, miR-37 1a-5p, miR-6765-3p, miR-6784-5p, miR-6778-5 p, miR-6875-5p, miR-4534, miR-4721, miR-6756 -5p, miR-615-5p, miR-6727-5p, miR-6887-5p, m iR-8063, miR-6880-5p, miR-6805-3p, miR-4726 -5p, miR-4710, miR-7111-5p, miR-3619-3p, miR -6795-5p, miR-1254, miR-1233-5p, miR-6836-3 p, miR-6769a-5p, miR-4532, miR-365a-5p, miR- 1231, miR-1228-5p, miR-4430, miR-296-3p, miR -1237-5p, miR-4466, miR-6789-5p, miR-4632-5 p, miR-4745-5p, miR-4665-5p, miR-6807-5p, and miR-7114-5p A device for detecting dementia, comprising a nucleic acid capable of binding. (6') The nucleic acid is a polynucleotide represented by any one of the following (a) to (e): (a) SEQ ID NOs: 194 to 210, 374, and 1315 to 1350 A polynucleotide consisting of a base sequence or a base sequence in which u is t , a variant thereof, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases, (b) SEQ ID NOs: 194 to 210, 374, and 1315 to 1350 a polynucleotide comprising a base sequence; (c) SEQ ID NOs: 194 to 210, 374, and 1315 to 1350 A base sequence that is complementary to a base sequence in which u is replaced by t. a polynucleotide containing 15 or more consecutive bases, a variant thereof, a derivative thereof, or a sequence thereof containing 15 or more consecutive bases piece, (d) SEQ ID NOs: 194 to 210, 374, and 1315 to 1350 Contains a base sequence or a base sequence complementary to the base sequence in which u is replaced by t polynucleotides, and (e) combining any one of the polynucleotides (a) to (d) under stringent conditions hybridizing polynucleotides, The device according to (5'), wherein the polynucleotide is selected from the group consisting of: (7') The device is configured to detect another dementia marker, miR-1225-3p, miR -3184-5p, miR-150-3p, miR-423-5p, miR-575, m Selected from the group consisting of iR-671-5p, miR-939-5p, and miR-3665 (5') or The device according to (6'). (8') The nucleic acid is a polynucleotide represented by any one of the following (f) to (j): (f) a nucleotide sequence represented by any one of SEQ ID NOs: 211 to 212 and 1351 to 1356 Or a polynucleotide consisting of a base sequence in which u is t in the base sequence, or a variant thereof variants, derivatives thereof, or fragments thereof containing 15 or more consecutive bases; (g) a nucleotide sequence represented by any one of SEQ ID NOs: 211 to 212 and 1351 to 1356 a polynucleotide comprising (h) a nucleotide sequence represented by any one of SEQ ID NOs: 211 to 212 and 1351 to 1356 Or a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t in the base sequence. a nucleotide, a variant thereof, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases; (i) a nucleotide sequence represented by any one of SEQ ID NOs: 211 to 212 and 1351 to 1356 Or a polynucleotide containing a base sequence complementary to the base sequence in which u is t in the base sequence. Reotide, and (j) combining the polynucleotide of any one of (f) to (i) under stringent conditions hybridizing polynucleotides, The device according to (7'), wherein the polynucleotide is selected from the group consisting of: (9') The device is a device for measurement by hybridization technology. The device according to any one of (5') to (8'). (10') The method according to (9'), wherein the hybridization technique is a nucleic acid array technique. device. (11') Dementia markers, miR-5698, miR-1915-3p, and miR -1343-5p, miR-6861-5p, miR-6781-5p, miR-450 8, miR-6743-5p, miR-6726-5p, miR-4525, miR-4 651, miR-6813-5p, miR-5787, miR-1290, miR-60 75, miR-4758-5p, miR-4690-5p, miR-762, miR-3 71a-5p, miR-6765-3p, miR-6784-5p, miR-6778- 5p, miR-6875-5p, miR-4534, miR-4721, miR-675 6-5p, miR-615-5p, miR-6727-5p, miR-6887-5p, miR-8063, miR-6880-5p, miR-6805-3p, miR-472 6-5p, miR-4710, miR-7111-5p, miR-3619-3p, mi R-6795-5p, miR-1254, miR-1233-5p, miR-6836- 3p, miR-6769a-5p, miR-4532, miR-365a-5p, miR -1231, miR-1228-5p, miR-4430, miR-296-3p, mi R-1237-5p, miR-4466, miR-6789-5p, miR-4632- 5p, miR-4745-5p, miR-4665-5p, miR-6807-5p, and and miR-7114-5p, The kit according to any one of (1') to (4'), which contains a nucleic acid capable of specifically binding thereto, or Using the device according to any one of (5') to (10'), a target in a specimen of a subject is detected. The expression level of the nucleic acid is measured, and the measured expression level is compared with the control expression level of a non-dementia sample measured in the same manner. Using the present amount, it is possible to evaluate in vitro whether a subject is suffering from dementia. and a method for detecting dementia, comprising: (12') Dementia markers, miR-5698, miR-1915-3p, and miR -1343-5p, miR-6861-5p, miR-6781-5p, miR-450 8, miR-6743-5p, miR-6726-5p, miR-4525, miR-4 651, miR-6813-5p, miR-5787, miR-1290, miR-60 75, miR-4758-5p, miR-4690-5p, miR-762, miR-3 71a-5p, miR-6765-3p, miR-6784-5p, miR-6778- 5p, miR-6875-5p, miR-4534, miR-4721, miR-675 6-5p, miR-615-5p, miR-6727-5p, miR-6887-5p, miR-8063, miR-6880-5p, miR-6805-3p, miR-472 6-5p, miR-4710, miR-7111-5p, miR-3619-3p, mi R-6795-5p, miR-1254, miR-1233-5p, miR-6836- 3p, miR-6769a-5p, miR-4532, miR-365a-5p, miR -1231, miR-1228-5p, miR-4430, miR-296-3p, mi R-1237-5p, miR-4466, miR-6789-5p, miR-4632- 5p, miR-4745-5p, miR-4665-5p, miR-6807-5p, and and miR-7114-5p, The kit according to any one of (1') to (4'), which contains a nucleic acid capable of specifically binding thereto, or A method for detecting a target gene in a specimen of a subject using the device according to any one of (5') to (10'). Gene expression levels were measured, and gene expression levels of samples from subjects known to have dementia were compared. The gene expression levels of samples from subjects with and without dementia were used as teacher samples, and A discriminant capable of distinguishing between dementia and non-dementia is prepared by adding a test compound to a sample derived from the subject. This involves substituting the expression level of the target gene into the phenotype, thereby assessing whether the patient has dementia or not. A method for detecting dementia in a subject. (13') The nucleic acid is a polynucleotide represented by any one of the following (a) to (e): (a) SEQ ID NOs: 194 to 210, 374, and 1315 to 1350 A polynucleotide consisting of a base sequence or a base sequence in which u is t , a variant thereof, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases, (b) SEQ ID NOs: 194 to 210, 374, and 1315 to 1350 a polynucleotide comprising a base sequence; (c) SEQ ID NOs: 194 to 210, 374, and 1315 to 1350 A base sequence that is complementary to a base sequence in which u is replaced by t. a polynucleotide containing 15 or more consecutive bases, a variant thereof, a derivative thereof, or a sequence thereof containing 15 or more consecutive bases piece, (d) SEQ ID NOs: 194 to 210, 374, and 1315 to 1350 Contains a base sequence or a base sequence complementary to the base sequence in which u is replaced by t polynucleotides, and (e) combining any one of the polynucleotides (a) to (d) under stringent conditions hybridizing polynucleotides, The polynucleotide according to (11') or (12') is selected from the group consisting of method. (14') The kit or device is a method for detecting miR-1225-, another dementia marker. 3p, miR-3184-5p, miR-150-3p, miR-423-5p, miR -575, miR-671-5p, miR-939-5p, and miR-3665 and a nucleic acid capable of specifically binding to at least one polynucleotide selected from the group consisting of: The method according to any one of (11') to (13'), comprising: (15') The nucleic acid is a polynucleotide represented by any one of the following (f) to (j): (f) a nucleotide sequence represented by any one of SEQ ID NOs: 211 to 212 and 1351 to 1356 Or a polynucleotide consisting of a base sequence in which u is t in the base sequence, or a variant thereof variants, derivatives thereof, or fragments thereof containing 15 or more consecutive bases; (g) a nucleotide sequence represented by any one of SEQ ID NOs: 211 to 212 and 1351 to 1356 a polynucleotide comprising (h) a nucleotide sequence represented by any one of SEQ ID NOs: 211 to 212 and 1351 to 1356 Or a polynucleotide consisting of a base sequence complementary to the base sequence in which u is t in the base sequence. a nucleotide, a variant thereof, a derivative thereof, or a fragment thereof containing 15 or more consecutive bases; (i) a nucleotide sequence represented by any one of SEQ ID NOs: 211 to 212 and 1351 to 1356 Or a polynucleotide containing a base sequence complementary to the base sequence in which u is t in the base sequence. Reotide, and (j) combining the polynucleotide of any one of (f) to (i) under stringent conditions hybridizing polynucleotides, The method according to (14'), wherein the polynucleotide is selected from the group consisting of: (16') The method according to any one of (11') to (15'), wherein the subject is a human. . (17') Any of (11') to (16'), wherein the sample is blood, serum, or plasma. The method described below.

[0041] In a preferred embodiment of the kit, device, or method for detecting dementia of the present invention, The types of dementia are Alzheimer's disease, vascular dementia, Lewy body dementia, People with diseases such as normal pressure hydrocephalus, frontotemporal lobar degeneration, neurofibrillary tangle dementia, and infectious diseases Dementia caused by alcoholism, dementia caused by alcoholism, or dementia caused by vitamin deficiency, Dementia of unknown or unspecified type.

[0042] Another preferred embodiment of the kit, device, or method for detecting dementia of the present invention In this study, miR-4274, a dementia marker, was found to be hsa-miR-4274. miR-4272 is hsa-miR-4272 and miR-4728-5p is hsa -miR-4728-5p, and miR-4443 is hsa-miR-4443 , miR-4506 is hsa-miR-4506, and miR-6773-5p is hs a-miR-6773-5p and miR-4662a-5p are hsa-miR-46 62a-5p, miR-3184-3p is hsa-miR-3184-3p , miR-4281 is hsa-miR-4281, and miR-320d is hsa-m iR-320d and miR-6729-3p is hsa-miR-6729-3p miR-5192 is hsa-miR-5192, and miR-6853-5p is hsa-miR-5192. sa-miR-6853-5p and miR-1234-3p are hsa-miR-12 34-3p, miR-1233-3p is hsa-miR-1233-3p, miR-4539 is hsa-miR-4539 and miR-3914 is hsa-mi R-3914, and miR-4738-5p is hsa-miR-4738-5p , miR-548au-3p is hsa-miR-548au-3p, and miR-15 39 is hsa-miR-1539, and miR-4720-3p is hsa-miR-4 720-3p, and miR-365b-5p is hsa-miR-365b-5p , miR-4486 is hsa-miR-4486, and miR-1227-5p is hs a-miR-1227-5p and miR-4667-5p are hsa-miR-466 7-5p, miR-6088 is hsa-miR-6088, and miR-682 0-5p is hsa-miR-6820-5p, and miR-4505 is hsa-miR -4505, miR-548q is hsa-miR-548q, and miR-46 58 is hsa-miR-4658, and miR-450a-5p is hsa-miR-4 50a-5p, miR-1260b is hsa-miR-1260b, and miR -3677-5p is hsa-miR-3677-5p, and miR-6777-3p is hsa-miR-6777-3p and miR-6826-3p are hsa-miR-6 826-3p, and miR-6832-3p is hsa-miR-6832-3p. , miR-4725-3p is hsa-miR-4725-3p, and miR-7161 -3p is hsa-miR-7161-3p, and miR-2277-5p is hsa-m iR-2277-5p and miR-7110-3p are hsa-miR-7110-3 p, miR-4312 is hsa-miR-4312, and miR-4461 is h sa-miR-4461 and miR-6766-5p is hsa-miR-6766- 5p, miR-1266-3p is hsa-miR-1266-3p, and miR -6729-5p is hsa-miR-6729-5p, and miR-526b-3p is hsa-miR-526b-3p and miR-519e-5p are hsa-miR-5 19e-5p, miR-512-5p is hsa-miR-512-5p, and m iR-5088-5p is hsa-miR-5088-5p, and miR-1909-3 p is hsa-miR-1909-3p and miR-6511a-5p is hsa-mi R-6511a-5p, miR-4734 is hsa-miR-4734, and m iR-936 is hsa-miR-936, and miR-1249-3p is hsa-mi miR-1249-3p and miR-6777-5p are hsa-miR-6777-5p , miR-4487 is hsa-miR-4487, and miR-3155a is h sa-miR-3155a, miR-563 is hsa-miR-563, and m iR-4741 is hsa-miR-4741, and miR-6788-5p is hsa- miR-6788-5p and miR-4433b-5p are hsa-miR-4433 b-5p, miR-323a-5p is hsa-miR-323a-5p, and m iR-6811-5p is hsa-miR-6811-5p and miR-6721-5 p is hsa-miR-6721-5p, and miR-5004-5p is hsa-miR -5004-5p and miR-6509-3p is hsa-miR-6509-3p miR-648 is hsa-miR-648 and miR-3917 is hsa-m iR-3917, miR-6087 is hsa-miR-6087, and miR- 1470 is hsa-miR-1470 and miR-586 is hsa-miR-586 and miR-3150a-5p is hsa-miR-3150a-5p, and miR -105-3p is hsa-miR-105-3p, and miR-7973 is hsa-m iR-7973 and miR-1914-5p are hsa-miR-1914-5p. miR-4749-3p is hsa-miR-4749-3p, and miR-15b -5p is hsa-miR-15b-5p, and miR-1289 is hsa-miR-1 289, and miR-4433a-5p is hsa-miR-4433a-5p; miR-3666 is hsa-miR-3666, and miR-3186-3p is hsa -miR-3186-3p and miR-4725-5p are hsa-miR-4725 -5p, miR-4488 is hsa-miR-4488, and miR-4474 -3p is hsa-miR-4474-3p, and miR-6731-3p is hsa-m iR-6731-3p and miR-4640-3p are hsa-miR-4640-3 p, miR-202-5p is hsa-miR-202-5p, and miR-68 16-5p is hsa-miR-6816-5p, and miR-638 is hsa-miR -638, miR-6821-5p is hsa-miR-6821-5p, and m iR-1247-3p is hsa-miR-1247-3p, and miR-6765-5 p is hsa-miR-6765-5p and miR-6800-5p is hsa-miR -6800-5p, and miR-3928-3p is hsa-miR-3928-3p miR-3940-5p is hsa-miR-3940-5p, and miR-39 60 is hsa-miR-3960, and miR-6775-5p is hsa-miR-6 775-5p, miR-3178 is hsa-miR-3178, and miR-1 202 is hsa-miR-1202, and miR-6790-5p is hsa-miR- 6790-5p, and miR-4731-3p is hsa-miR-4731-3p. miR-2681-3p is hsa-miR-2681-3p, and miR-675 8-5p is hsa-miR-6758-5p, and miR-8072 is hsa-miR -8072, and miR-518d-3p is hsa-miR-518d-3p; miR-3606-3p is hsa-miR-3606-3p, and miR-4800- 5p is hsa-miR-4800-5p and miR-1292-3p is hsa-mi miR-1292-3p and miR-6784-3p are hsa-miR-6784-3p , miR-4450 is hsa-miR-4450, and miR-6132 is hs a-miR-6132 and miR-4716-5p is hsa-miR-4716-5 p, miR-6860 is hsa-miR-6860, and miR-1268b is hsa-miR-1268b and miR-378d miR-4701-5p is hsa-miR-4701-5p, and miR-432 9 is hsa-miR-4329, and miR-185-3p is hsa-miR-185 -3p, miR-552-3p is hsa-miR-552-3p, and miR- 1273g-5p is hsa-miR-1273g-5p, and miR-6769b-3 p is hsa-miR-6769b-3p, and miR-520a-3p is hsa-mi R-520a-3p and miR-4524b-5p are hsa-miR-4524b- 5p, miR-4291 is hsa-miR-4291, and miR-6734- 3p is hsa-miR-6734-3p, and miR-143-5p is hsa-miR -143-5p, and miR-939-3p is hsa-miR-939-3p; miR-6889-3p is hsa-miR-6889-3p, and miR-6842- 3p is hsa-miR-6842-3p, and miR-4511 is hsa-miR-4 511, miR-4318 is hsa-miR-4318, and miR-4653 -5p is hsa-miR-4653-5p, and miR-6867-3p is hsa-m iR-6867-3p, miR-133b is hsa-miR-133b, and m iR-3196 is hsa-miR-3196, and miR-193b-3p is hsa- miR-193b-3p and miR-3162-3p are hsa-miR-3162- 3p, miR-6819-3p is hsa-miR-6819-3p, and miR -1908-3p is hsa-miR-1908-3p, and miR-6786-5p is hsa-miR-6786-5p and miR-3648 , miR-4513 is hsa-miR-4513, and miR-3652 is hs a-miR-3652 and miR-4640-5p is hsa-miR-4640-5 p, miR-6871-5p is hsa-miR-6871-5p, and miR- 7845-5p is hsa-miR-7845-5p, and miR-3138 is hsa- miR-3138 and miR-6884-5p are hsa-miR-6884-5p. miR-4653-3p is hsa-miR-4653-3p, and miR-63 6 is hsa-miR-636, and miR-4652-3p is hsa-miR-465 2-3p, miR-6823-5p is hsa-miR-6823-5p, and m iR-4502 is hsa-miR-4502, and miR-7113-5p is hsa- miR-7113-5p, miR-8087 is hsa-miR-8087, miR-7154-3p is hsa-miR-7154-3p, and miR-5189- 5p is hsa-miR-5189-5p, and miR-1253 is hsa-miR-1 253, miR-518c-5p is hsa-miR-518c-5p, and mi R-7151-5p is hsa-miR-7151-5p, and miR-3614-3p is hsa-miR-3614-3p, and miR-4727-5p is hsa-miR- 4727-5p, and miR-3682-5p is hsa-miR-3682-5p. miR-5090 is hsa-miR-5090, and miR-337-3p is hs a-miR-337-3p and miR-488-5p is hsa-miR-488-5 p, miR-100-5p is hsa-miR-100-5p, and miR-45 20-3p is hsa-miR-4520-3p, and miR-373-3p is hsa- miR-373-3p and miR-6499-5p are hsa-miR-6499-5 p, miR-3909 is hsa-miR-3909, and miR-32-5p is hsa-miR-32-5p and miR-302a-3p are hsa-miR-302 a-3p, miR-4686 is hsa-miR-4686, and miR-465 9a-3p is hsa-miR-4659a-3p, and miR-4287 is hsa-m iR-4287 and miR-1301-5p is hsa-miR-1301-5p miR-593-3p is hsa-miR-593-3p, and miR-517a- 3p is hsa-miR-517a-3p, and miR-517b-3p is hsa-mi miR-517b-3p and miR-142-3p are hsa-miR-142-3p. miR-1185-2-3p is hsa-miR-1185-2-3p, and miR -602 is hsa-miR-602, and miR-527 is hsa-miR-527. miR-518a-5p is hsa-miR-518a-5p, and miR-46 82 is hsa-miR-4682, and miR-28-5p is hsa-miR-28- 5p, miR-4252 is hsa-miR-4252, and miR-452-5 p is hsa-miR-452-5p and miR-525-5p is hsa-miR-5 25-5p, and miR-3622a-3p is hsa-miR-3622a-3p. miR-6813-3p is hsa-miR-6813-3p, and miR-476 9-3p is hsa-miR-4769-3p, and miR-5698 is hsa-miR -5698, and miR-1915-3p is hsa-miR-1915-3p, miR-1343-5p is hsa-miR-1343-5p, and miR-6861- 5p is hsa-miR-6861-5p, and miR-6781-5p is hsa-mi miR-6781-5p, miR-4508 is hsa-miR-4508, and mi R-6743-5p is hsa-miR-6743-5p, and miR-6726-5p is hsa-miR-6726-5p, and miR-4525 is hsa-miR-452 5, miR-4651 is hsa-miR-4651, and miR-6813-5 p is hsa-miR-6813-5p and miR-5787 is hsa-miR-57 87, miR-1290 is hsa-miR-1290, and miR-6075 is hsa-miR-6075 and miR-4758-5p are hsa-miR-4758 -5p, miR-4690-5p is hsa-miR-4690-5p, and mi R-762 is hsa-miR-762, and miR-1225-3p is hsa-miR -1225-3p, and miR-3184-5p is hsa-miR-3184-5p. miR-665 is hsa-miR-665, and miR-211-5p is hsa -miR-211-5p, and miR-1247-5p is hsa-miR-1247- 5p, miR-3656 is hsa-miR-3656, and miR-149-5 p is hsa-miR-149-5p, and miR-744-5p is hsa-miR-7 44-5p, miR-345-5p is hsa-miR-345-5p, and mi R-150-5p is hsa-miR-150-5p, and miR-191-3p is hs a-miR-191-3p and miR-651-5p are hsa-miR-651-5 p, miR-34a-5p is hsa-miR-34a-5p, and miR-40 9-5p is hsa-miR-409-5p, and miR-369-5p is hsa-mi miR-369-5p and miR-1915-5p are hsa-miR-1915-5p. miR-204-5p is hsa-miR-204-5p, and miR-137 is hsa-miR-137 and miR-382-5p , miR-517-5p is hsa-miR-517-5p, and miR-532 -5p is hsa-miR-532-5p, and miR-22-5p is hsa-miR- 22-5p, and miR-1237-3p is hsa-miR-1237-3p; miR-1224-3p is hsa-miR-1224-3p, and miR-625-3 p is hsa-miR-625-3p, and miR-328-3p is hsa-miR-3 28-3p, miR-122-5p is hsa-miR-122-5p, and mi R-202-3p is hsa-miR-202-3p, and miR-4781-5p is h sa-miR-4781-5p, and miR-718 is hsa-miR-718 , miR-342-3p is hsa-miR-342-3p, and miR-26b-3p is hsa-miR-26b-3p, and miR-140-3p is hsa-miR-14 0-3p, miR-200a-3p is hsa-miR-200a-3p, and m iR-378a-3p is hsa-miR-378a-3p, and miR-484 is hs a-miR-484 and miR-296-5p is hsa-miR-296-5p miR-205-5p is hsa-miR-205-5p, and miR-431-5 p is hsa-miR-431-5p and miR-1471 is hsa-miR-147 1, miR-1538 is hsa-miR-1538, and miR-449b-3 p is hsa-miR-449b-3p, and miR-1976 is hsa-miR-19 76, miR-4268 is hsa-miR-4268, and miR-4279 is hsa-miR-4279 and miR-3620-3p are hsa-miR-3620 -3p, miR-3944-3p is hsa-miR-3944-3p, and mi R-3156-3p is hsa-miR-3156-3p, and miR-3187-5p is hsa-miR-3187-5p, and miR-4685-3p is hsa-miR- 4685-3p, and miR-4695-3p is hsa-miR-4695-3p. miR-4697-3p is hsa-miR-4697-3p, and miR-471 3-5p is hsa-miR-4713-5p, and miR-4723-3p is hsa- miR-4723-3p and miR-371b-3p are hsa-miR-371b- 3p, miR-3151-3p is hsa-miR-3151-3p, and miR -3192-3p is hsa-miR-3192-3p, and miR-6728-3p is hsa-miR-6728-3p and miR-6736-3p are hsa-miR-6 736-3p, and miR-6740-3p is hsa-miR-6740-3p , miR-6741-3p is hsa-miR-6741-3p, and miR-6743 -3p is hsa-miR-6743-3p, and miR-6747-3p is hsa-m iR-6747-3p and miR-6750-3p are hsa-miR-6750-3 p, miR-6754-3p is hsa-miR-6754-3p, and miR- 6759-3p is hsa-miR-6759-3p, and miR-6761-3p is h sa-miR-6761-3p and miR-6762-3p are hsa-miR-67 62-3p, and miR-6769a-3p is hsa-miR-6769a-3p. miR-6776-3p is hsa-miR-6776-3p, and miR-677 8-3p is hsa-miR-6778-3p, and miR-6779-3p is hsa- miR-6779-3p and miR-6786-3p are hsa-miR-6786- 3p, miR-6787-3p is hsa-miR-6787-3p, and miR -6792-3p is hsa-miR-6792-3p, and miR-6794-3p is hsa-miR-6794-3p and miR-6801-3p are hsa-miR-6 miR-6801-3p is hsa-miR-6802-3p, and miR-6802-3p is hsa-miR-6802-3p. , miR-6803-3p is hsa-miR-6803-3p, and miR-6804 -3p is hsa-miR-6804-3p, and miR-6810-5p is hsa-m iR-6810-5p and miR-6823-3p are hsa-miR-6823-3 p, miR-6825-3p is hsa-miR-6825-3p, and miR- 6829-3p is hsa-miR-6829-3p and miR-6833-3p is h sa-miR-6833-3p and miR-6834-3p are hsa-miR-68 34-3p, and miR-6780b-3p is hsa-miR-6780b-3p. miR-6845-3p is hsa-miR-6845-3p, and miR-686 2-3p is hsa-miR-6862-3p, and miR-6865-3p is hsa- miR-6865-3p and miR-6870-3p are hsa-miR-6870- 3p, miR-6875-3p is hsa-miR-6875-3p, and miR -6877-3p is hsa-miR-6877-3p, and miR-6879-3p is hsa-miR-6879-3p and miR-6882-3p are hsa-miR-6 882-3p, and miR-6885-3p is hsa-miR-6885-3p , miR-6886-3p is hsa-miR-6886-3p, and miR-6887 -3p is hsa-miR-6887-3p, and miR-6890-3p is hsa-m iR-6890-3p and miR-6893-3p are hsa-miR-6893-3 p, miR-6894-3p is hsa-miR-6894-3p, and miR- 7106-3p is hsa-miR-7106-3p, and miR-7109-3p is h sa-miR-7109-3p and miR-7114-3p are hsa-miR-71 14-3p, and miR-7155-5p is hsa-miR-7155-5p; miR-7160-5p is hsa-miR-7160-5p, and miR-615-3 p is hsa-miR-615-3p and miR-920 is hsa-miR-920 miR-1825 is hsa-miR-1825, and miR-675-3p is h sa-miR-675-3p and miR-1910-5p are hsa-miR-191 0-5p, miR-2278 is hsa-miR-2278, and miR-268 2-3p is hsa-miR-2682-3p, and miR-3122 is hsa-miR -3122, and miR-3151-5p is hsa-miR-3151-5p; miR-3175 is hsa-miR-3175 and miR-4323 is hsa-mi miR-4323, miR-4326 is hsa-miR-4326, and miR-4 284 is hsa-miR-4284, and miR-3605-3p is hsa-miR- 3605-3p, and miR-3622b-5p is hsa-miR-3622b-5p , miR-3646 is hsa-miR-3646, and miR-3158-5p is hsa-miR-3158-5p, and miR-4722-3p is hsa-miR- 4722-3p, and miR-4728-3p is hsa-miR-4728-3p. miR-4747-3p is hsa-miR-4747-3p, and miR-443 6b-5p is hsa-miR-4436b-5p, and miR-5196-3p is hs a-miR-5196-3p and miR-5589-5p are hsa-miR-558 9-5p, miR-345-3p is hsa-miR-345-3p, and miR -642b-5p is hsa-miR-642b-5p, and miR-6716-3p is hsa-miR-6716-3p, and miR-6511b-3p is hsa-miR- 6511b-3p, and miR-208a-5p is hsa-miR-208a-5p. miR-6726-3p is hsa-miR-6726-3p, and miR-67 44-5p is hsa-miR-6744-5p, and miR-6782-3p is hsa -miR-6782-3p, and miR-6789-3p is hsa-miR-6789 -3p, miR-6797-3p is hsa-miR-6797-3p, and mi R-6800-3p is hsa-miR-6800-3p, and miR-6806-5p is hsa-miR-6806-5p, and miR-6824-3p is hsa-miR- 6824-3p, and miR-6837-5p is hsa-miR-6837-5p. miR-6846-3p is hsa-miR-6846-3p, and miR-685 8-3p is hsa-miR-6858-3p, and miR-6859-3p is hsa- miR-6859-3p and miR-6861-3p are hsa-miR-6861- 3p, miR-6880-3p is hsa-miR-6880-3p, and miR -7111-3p is hsa-miR-7111-3p, and miR-7152-5p is hsa-miR-7152-5p and miR-642a-5p are hsa-miR-6 42a-5p, miR-657 is hsa-miR-657, and miR-123 6-3p is hsa-miR-1236-3p, and miR-764 is hsa-miR- 764, miR-4314 is hsa-miR-4314, and miR-3675 -3p is hsa-miR-3675-3p, and miR-5703 is hsa-miR- 5703, miR-3191-5p is hsa-miR-3191-5p, and m iR-6511a-3p is hsa-miR-6511a-3p, and miR-6809 -3p is hsa-miR-6809-3p, and miR-6815-5p is hsa-m iR-6815-5p and miR-6857-3p are hsa-miR-6857-3 p, miR-6878-3p is hsa-miR-6878-3p, and miR- 371a-5p is hsa-miR-371a-5p, and miR-766-3p is hs a-miR-766-3p and miR-1229-3p are hsa-miR-1229 -3p, miR-1306-5p is hsa-miR-1306-5p, and mi miR-210-5p is hsa-miR-210-5p, and miR-198 is hsa-m iR-198, miR-485-3p is hsa-miR-485-3p, and m iR-668-3p is hsa-miR-668-3p, and miR-532-3p is h sa-miR-532-3p and miR-877-3p are hsa-miR-877- 3p, miR-1238-3p is hsa-miR-1238-3p, and miR -3130-5p is hsa-miR-3130-5p, and miR-4298 is hsa -miR-4298, miR-4290 is hsa-miR-4290, and mi R-3943 is hsa-miR-3943, and miR-346 is hsa-miR-3 46, miR-767-3p is hsa-miR-767-3p, and miR-5 16a-5p is hsa-miR-516a-5p, and miR-769-3p is hsa -miR-769-3p, and miR-3692-5p is hsa-miR-3692- 5p, miR-3945 is hsa-miR-3945, and miR-4433a -3p is hsa-miR-4433a-3p, and miR-4485-3p is hsa- miR-4485-3p and miR-6831-5p are hsa-miR-6831- 5p, miR-519c-5p is hsa-miR-519c-5p, and miR -551b-5p is hsa-miR-551b-5p, and miR-1343-3p is hsa-miR-1343-3p and miR-4286 , miR-4634 is hsa-miR-4634, and miR-4733-3p is hsa-miR-4733-3p, and miR-6086 is hsa-miR-608 6, miR-30d-5p is hsa-miR-30d-5p, and miR-30 b-3p is hsa-miR-30b-3p, and miR-92a-3p is hsa-mi miR-92a-3p and miR-371b-5p are hsa-miR-371b-5p. and miR-486-5p is hsa-miR-486-5p.

[0043] Another preferred embodiment of the kit, device, or method for detecting dementia of the present invention In this study, miR-6765-3p, a dementia marker, was detected in hsa-miR-6765- 3p, miR-6784-5p is hsa-miR-6784-5p, and miR -5698 is hsa-miR-5698, and miR-6778-5p is hsa-mi R-6778-5p and miR-1915-3p are hsa-miR-1915-3p , miR-6875-5p is hsa-miR-6875-5p, and miR-1 343-5p is hsa-miR-1343-5p, and miR-4534 is hsa-m iR-4534 and miR-6861-5p are hsa-miR-6861-5p. miR-4721 is hsa-miR-4721, and miR-6756-5p is hsa-miR-4721. sa-miR-6756-5p and miR-615-5p is hsa-miR-615 -5p, miR-6727-5p is hsa-miR-6727-5p, and mi R-6887-5p is hsa-miR-6887-5p, and miR-8063 is hs a-miR-8063 and miR-6880-5p is hsa-miR-6880-5 p, miR-6805-3p is hsa-miR-6805-3p, and miR- 6781-5p is hsa-miR-6781-5p, and miR-4508 is hsa- miR-4508 and miR-4726-5p are hsa-miR-4726-5p. miR-4710 is hsa-miR-4710, and miR-7111-5p is hsa-miR-7111-5p and miR-3619-3p are hsa-miR-3 619-3p, and miR-6743-5p is hsa-miR-6743-5p , miR-6795-5p is hsa-miR-6795-5p, and miR-6726 -5p is hsa-miR-6726-5p, and miR-4525 is hsa-miR- 4525, miR-1254 is hsa-miR-1254, and miR-123 3-5p is hsa-miR-1233-5p, and miR-4651 is hsa-miR -4651, and miR-6836-3p is hsa-miR-6836-3p; miR-6769a-5p is hsa-miR-6769a-5p, and miR-681 3-5p is hsa-miR-6813-5p, and miR-4532 is hsa-miR -4532, and miR-365a-5p is hsa-miR-365a-5p; miR-1231 is hsa-miR-1231 and miR-5787 is hsa-mi R-5787, miR-1290 is hsa-miR-1290, and miR-1 228-5p is hsa-miR-1228-5p, and miR-371a-5p is hs a-miR-371a-5p, and miR-4430 is hsa-miR-4430. miR-296-3p is hsa-miR-296-3p, and miR-6075 is hsa-miR-6075 and miR-1237-5p are hsa-miR-1237 -5p, miR-4758-5p is hsa-miR-4758-5p, and mi R-4690-5p is hsa-miR-4690-5p, and miR-4466 is hs a-miR-4466 and miR-6789-5p is hsa-miR-6789-5 p, miR-4632-5p is hsa-miR-4632-5p, and miR- 4745-5p is hsa-miR-4745-5p and miR-4665-5p is h sa-miR-4665-5p and miR-6807-5p are hsa-miR-68 07-5p, miR-762 is hsa-miR-762, and miR-7114 -5p is hsa-miR-7114-5p, and miR-150-3p is hsa-mi miR-150-3p and miR-423-5p is hsa-miR-423-5p , miR-575 is hsa-miR-575, and miR-671-5p is hsa-m iR-671-5p and miR-939-5p are hsa-miR-939-5p. miR-1225-3p is hsa-miR-1225-3p, and miR-318 4-5p is hsa-miR-3184-5p, and miR-3665 is hsa-miR It is -3665.

[0044] <Terminology> Terms used herein have the following definitions.

[0045] Nucleotide, polynucleotide, DNA, RNA, etc. are abbreviated as "base sequence" Guidelines for the Preparation of Specifications Including Sequences or Amino Acid Sequences" (edited by the Japan Patent Office) and and conventions in the art shall be followed.

[0046] As used herein, the term "polynucleotide" refers to RNA, DNA, and RNA / DNA ( The term "DNA" refers to nucleic acids that include both cDNA and chimeric DNA. The above-mentioned RNA includes total DNA, genomic DNA, and synthetic DNA. l RNA, mRNA, rRNA, miRNA, siRNA, snoRNA, snRNA In this specification, the term "RNA" includes both non-coding RNA and synthetic RNA. "Synthetic DNA" and "synthetic RNA" are defined as those that contain a specific base sequence (either a natural sequence or a non-natural sequence). ) can be artificially produced using, for example, an automatic nucleic acid synthesizer. As used herein, the term "non-natural sequence" is used in a broad sense. The term "naturally occurring sequence" refers to a sequence that differs from the native sequence by, for example, one or more nucleotide substitutions, deletions, or insertions. sequences containing insertions and / or additions (i.e., mutant sequences), including one or more modified nucleotides; sequences (i.e., modified sequences), etc. Also, as used herein, polynucleotides is used interchangeably with nucleic acid.

[0047] As used herein, the term "fragment" refers to a fragment having a continuous partial base sequence of a polynucleotide. It is a polynucleotide having 15 or more bases, preferably 17 or more bases, and more preferably 1 It is desirable that the length be 9 bases or more.

[0048] As used herein, the term "gene" refers not only to RNA and double-stranded DNA, but also to any of the components thereof. Each strand contains a single strand of DNA, such as the positive strand (or sense strand) or the complementary strand (or antisense strand). The term "subject matter" is intended to encompass all subjects, and is not particularly limited by its length.

[0049] Therefore, in this specification, unless otherwise specified, the term "gene" includes human genomic DNA. Double-stranded DNA, single-stranded DNA (positive strand), and single-stranded DNA with a sequence complementary to the positive strand (complementary strand), cDNA, microRNA (miRNA), and their fragments, human genome The term "gene" includes a specific base sequence (or sequence) and its transcription product. Not only "genes" represented by the sequence numbers, but also the RNA and biological RNAs with equivalent biological functions, e.g., homologs (i.e., homologs or orthologs) The term "nucleic acid" includes variants such as polymorphisms and derivatives thereof. Specific examples of "nucleic acids" that encode the clones, mutants, or derivatives include the streams described below. Under irritant conditions, SEQ ID NOs: 1 to 1314, 1315 to 1434, and 1435 to 1 505 (e.g., SEQ ID NOs: 194 to 212, 374, 398, 490, 591, 593 to 609, 766, 1015-1017, 1019-1024, 1026-1031, 12 85 to 1286, and 1315 to 1434) or the corresponding base sequence The base sequence has a base sequence that hybridizes with the complementary sequence of the base sequence in which u is t. The term "gene" does not refer to any specific functional region. It may include, for example, an expression control region, a coding region, an exon, or an intron. Furthermore, a "gene" may be contained within a cell, or may be released outside the cell and exist independently. They may also be encapsulated in small vesicles called exosomes.

[0050] As used herein, "exosome" or "exosome" refers to lipids secreted from cells. Exosomes are small vesicles enclosed in a plasma bilayer. They originate from multivesicular endosomes and are transported into the extracellular environment. When released into the atmosphere, they contain biological substances such as RNA, DNA, and proteins. Exosomes are known to be contained in bodily fluids such as blood, serum, plasma, and lymph. It is being done.

[0051] As used herein, the term "transcription product" refers to a RNA synthesized using the DNA sequence of a gene as a template. A refers to the region called the promoter upstream of the gene where RNA polymerase is located. and binds to the 3' end of the DNA, and binds a ribonucleotide to the 3' end so that it is complementary to the base sequence of the DNA. This RNA contains not only the gene itself but also the the region from the transcription start site to the poly(A) sequence, including the coding region, exon or intron The entire sequence is included, all the way to the termini.

[0052] In addition, in this specification, unless otherwise specified, "microRNA (miRNA)" means It is transcribed as a hairpin-like RNA precursor and has RNase III cleavage activity. It is cleaved by sRNA cleavage enzymes and incorporated into a protein complex called RISC, Non-coding RNAs of 15 to 25 bases involved in RNA translational repression are used intentionally. Furthermore, as used herein, "miRNA" is represented by a specific base sequence (or SEQ ID NO:). In addition to the miRNAs themselves, we also study the precursors of these miRNAs (pre-miRNAs, p ri-miRNAs) and the miRNAs encoded by them and their biological functions. Equivalent miRNAs, e.g., homologs (i.e., homologs or orthologs), genetic The term "miRNA" also encompasses variants, such as polymorphisms, and derivatives thereof. Specifically, "miRNA" encoding a homologue, variant or derivative thereof includes "mi The data can be identified using the RBase (version 21) and the streams described later. Under irritant conditions, SEQ ID NOs: 1 to 1314, 1315 to 1434, and 1435 to 1 505 (e.g., SEQ ID NOs: 194 to 212, 374, 398, 490, 591, 593 to 609, 766, 1015-1017, 1019-1024, 1026-1031, 12 Any specific base sequence represented by any of the following: Examples of such miRNAs include "miRNAs" that have a base sequence that hybridizes with a complementary sequence of a target gene. "miRBase" (version 21) provides information on miRNA base sequences and algorithms. It is a web-based database that provides annotations, predictions of target genes, etc. ( http: / / www.mirbase.org / ). Registered in "miRBase" All miRNAs have been cloned or have been shown to be expressed in vivo. The scope of the present invention is limited to those that have been processed and are shown to have undergone processing. As used herein, "miRNA" may refer to the gene product of a miR gene. The gene products are mature miRNAs (e.g., involved in translational repression of mRNAs as described above). Non-coding RNA (15-25 bases or 19-25 bases) or miRNA precursor (e.g., pre-miRNA or pri-miRNA as described above).

[0053] As used herein, the term "probe" refers to RNA generated by gene expression or a probe derived therefrom. Polynucleotides and / or includes polynucleotides complementary thereto.

[0054] As used herein, the term "primer" refers to an RNA generated by gene expression or a primer therefor. A contiguous polynucleotide that specifically recognizes and amplifies the polynucleotide from which it is derived, and and / or a polynucleotide complementary thereto.

[0055] Here, the "complementary polynucleotide" (complementary strand, reverse strand) refers to SEQ ID NOs: 1 to 1314 , 1315 to 1434, and 1435 to 1505 (for example, SEQ ID NOs: 194 to 212, 3 74, 398, 490, 591, 593-609, 766, 1015-1017, 101 9-1024, 1026-1031, 1285-1286, and 1315-1434) A base sequence defined by either of these or a base sequence in which u is t The full-length sequence of a polynucleotide consisting of a sequence, or a partial sequence thereof (for convenience, this is referred to as the positive base-complementary to the nucleotide sequence (called the "strand") based on base pairing relationships such as A:T(U) and G:C The term "complementary strand" refers to a polynucleotide that is in a complementary relationship to the target strand. It is not limited to cases where the base sequence is completely complementary to the target positive strand. The complementary relationship may be such that the hybridization occurs under normal conditions.

[0056] As used herein, "stringent conditions" refers to conditions under which a nucleic acid probe is highly sensitive to other sequences. to a detectably greater extent (e.g., the average of background measurements plus background The number of hybridizations to the target sequence is determined by the number of hybridizations (measurements of at least 2 times the standard error of the round measurement). Stringent conditions are sequence-dependent and are conditions under which hybridization is The stringency of hybridization and / or washing conditions varies depending on the environment in which they are performed. By controlling the gene expression, a target sequence that is 100% complementary to the nucleic acid probe is obtained. Specific examples of "stringent conditions" are described below.

[0057] As used herein, the term "Tm value" refers to the time at which the double-stranded portion of a polynucleotide is denatured into a single strand. means the temperature at which double-stranded and single-stranded molecules exist in a 1:1 ratio.

[0058] As used herein, the term "variant" refers to a naturally occurring variant of a nucleic acid resulting from polymorphism, mutation, etc. or a variant of the base sequence represented by the sequence number or the base sequence in which u is t In a certain base sequence or a partial sequence thereof, one, two, three or more (e.g., one to several a mutant containing a deletion, substitution, addition or insertion of nucleotides (number of nucleotides), or a mutant containing a sequence of SEQ ID NO: 1 to 210, 2 11~249, 250~374, and 375~390, 1315~1350, 1351~ Precursor RN of any of the sequences 1356, 1435 to 1448, and 1449 to 1453 The base sequence of A (premature miRNA) or the base sequence in which u is A base sequence that is t, or a partial sequence thereof, in which one or more bases are deleted, substituted, added, or inserted. or a variant containing the base sequence or a partial sequence thereof, and or more, about 97% or more, about 98% or more, or about 99% or more percent identity, or A polynucleotide or oligonucleotide containing the base sequence or a partial sequence thereof as defined above The term "nucleic acid" refers to a nucleic acid that hybridizes under stringent conditions.

[0059] As used herein, "several" refers to an integer of about 10, 9, 8, 7, 6, 5, 4, 3, or 2. means.

[0060] As used herein, the term "mutant" refers to a mutation obtained by site-directed mutagenesis or PCR. They can be produced using well-known techniques such as heterotransferase.

[0061] As used herein, "% identity" refers to the percentage of identity found using BLAST (https: / / blast.ncb i.nlm.nih.gov / Blast.cgi) and FASTA (http: / / ww Protein or gene detection using the fasta (www.genome.jp / tools / fasta / ) Determining the gap width using a search system with or without introducing a gap (Zheng Zhang et al., 2000, J. Comput. Biol. , vol. 7, pp. 203-214; Altschul, S. F. et al., 1990, Journa l of Molecular Biology, Vol. 215, p403-410;Pe arson, W.R. et al., 1988, Proc. Natl. Acad. Sci. USA, Vol. 85, p2444-2448).

[0062] As used herein, the term "derivative" refers to a modified nucleic acid, for example, but not limited to, labeling with a fluorophore or the like. modified nucleotides (e.g., halogenated, alkyl, such as methyl, methoxy, etc.); Reconstruction of nucleotides and bases containing alkoxy, thio, carboxymethyl, etc. groups nucleotides that have undergone double bond saturation, deamination, and substitution of oxygen molecules with sulfur molecules derivatives including PNA (peptide nucleic acid; Niel Sen, PE et al., 1991, Science, Vol. 254, pp. 1497-500) LNA (locked nucleic acid; Obika, S. et al., 1998) , Tetrahedron Lett., Vol. 39, p5401-5404) This means:

[0063] As used herein, a polynucleotide selected from the miRNAs that are dementia markers is The "nucleic acid" capable of specifically binding to the complementary strand of the polynucleotide or the polynucleotide can be synthesized or prepared. Specifically, it includes a "nucleic acid probe" or a "primer" and is used to detect a nucleic acid in a subject. To detect the presence or absence of dementia, or to determine the presence or absence, severity, or severity of dementia To diagnose whether or not there is improvement, the degree of improvement, or the sensitivity to treatment for dementia, or to To screen for candidate substances useful for the prevention, amelioration or treatment of diseases, These include the testing of body fluids, particularly blood and urine, in relation to dementia. In the body, SEQ ID NOs: 1 to 1314, 1315 to 1434, and 1435 to 1505 (e.g. For example, SEQ ID NOs: 194 to 212, 374, 398, 490, 591, 593 to 609, 7 66, 1015-1017, 1019-1024, 1026-1031, 1285-12 86, and 1315-1434) or its cDNA synthesis nucleic acid nucleotides and oligonucleotides that can specifically recognize and bind to the nucleic acids or their complementary strands. These nucleotides, oligonucleotides, and polynucleotides are included. Based on the above properties, the genes and polynucleotides are expressed in vivo, in tissues, cells, etc. It can be used as a probe for detecting the above gene and for amplifying the above gene expressed in vivo. It can be effectively used as a primer for

[0064] The term "detection" as used herein means inspection, measurement, detection, or decision support. In addition, the term "evaluation" as used herein refers to test results or measurement results. It is used to include assisting in diagnosis or evaluation based on the above.

[0065] As used herein, a "subject" refers to a human, a primate, including a chimpanzee, a dog, a cat, or the like. Any pet animals, livestock animals such as cows, horses, sheep, goats, rodents such as mice and rats The preferred subject is a human. Furthermore, "cognitively normal individuals" are also such mammals, and A cognitively normal individual is a cognitively normal individual, or a cognitively normal individual.

[0066] As used herein, "dementia" refers to the loss of once normal cognitive function due to an acquired brain disorder. Generally, it refers to a state of persistent decline that interferes with daily life and social life. It is diagnosed when a significant degree of functional decline is observed.

[0067] Dementia is generally classified into Alzheimer's disease, vascular dementia, and Levitra. These are classified into disease types such as dementia with leukocyte bodies, normal pressure hydrocephalus, and frontotemporal lobar degeneration. The types of dementia that are mentioned include Alzheimer's disease, vascular dementia, Lewy body dementia, and Normal pressure hydrocephalus, frontotemporal lobar degeneration, neurofibrillary tangle dementia, other diseases (infectious diseases, etc.) This includes dementia caused by alcohol, vitamin deficiency, etc. In addition, the term "dementia" in the present invention also includes dementia that is a mixed type of any of these disease types. Furthermore, dementia of unknown or unspecified type is also included in the "dementia" of the present invention. can be.

[0068] As used herein, "Alzheimer's disease" refers to dementia that is diagnosed using imaging techniques such as CT, MRI, and PET. Imaging tests revealed no abnormal structures in the brain, but atrophy of the medial temporal lobe was observed, suggesting that this was the core of cognitive and memory impairment. The main symptom is dementia, which causes memory loss.

[0069] As used herein, "vascular dementia" refers to cognitive and memory impairment that occurs in association with cerebrovascular disease. The damage is uneven or patchy, with a decline in memory and intellectual ability, but awareness of the illness and judgment are relatively well preserved. It is a type of dementia that develops over time.

[0070] As used herein, "dementia with Lewy bodies" refers to the condition characterized by cerebral blood flow SPECT or PET imaging. Imaging revealed decreased dopamine transporter uptake in the basal ganglia. Symptoms include fluctuating cognitive impairment, recurring visual hallucinations with specific details, and parkinsonism. Dementia with phononism.

[0071] As used herein, "normal pressure hydrocephalus" refers to a condition in which cerebrospinal fluid accumulates in the ventricles of the brain and presses on the surrounding brain. This is a type of dementia that causes cognitive impairment, walking difficulties, and urinary problems. It is a type of dementia that can be improved.

[0072] As used herein, "frontotemporal lobar degeneration" refers to a condition characterized by significant atrophy of the frontal and temporal lobes. This is a type of dementia that presents with language disorders and psychiatric symptoms.

[0073] As used herein, "P" or "P value" refers to the probability that a statistical test will yield a positive result under the null hypothesis. indicates the probability that a statistic more extreme than the statistic calculated from the actual data will be observed. Therefore, the smaller the "P" or "P value," the more significant the difference between the compared subjects.

[0074] As used herein, "sensitivity" refers to the value of (the number of true positives) / (the number of true positives + the number of false negatives). High sensitivity means that dementia can be detected early, allowing for early medical intervention. It becomes Noh.

[0075] As used herein, "specificity" means (number of true negatives) / (number of true negatives + number of false positives). High specificity can prevent unnecessary follow-up due to misclassification of cognitively normal individuals as dementia patients. This will prevent the need for additional testing, reducing the burden on patients and cutting medical costs.

[0076] In this specification, "accuracy" means the value of (number of true positives + number of true negatives) / (total number of cases). Accuracy indicates the percentage of all samples for which the discrimination results were correct, and is used to evaluate detection performance. This will be the first indicator.

[0077] In this specification, the term "sample" as a target of determination, detection or diagnosis refers to a sample that is used to determine whether or not dementia has occurred, whether or not cognitive function has improved, or whether or not cognitive function has improved. The expression of the gene of the present invention changes with the progression of the disease and the exertion of therapeutic effects against dementia. This refers to tissues and biological materials, specifically brain tissue and nerve cells, neural tissue, cerebrospinal fluid, and bone marrow fluid. , organs, skin, and body fluids such as blood, urine, saliva, sweat, tissue exudates, and blood preparations Furthermore, biological samples extracted from these include serum, plasma, stool, hair, etc. Specifically, it refers to genes such as RNA and miRNA.

[0078] As used herein, "hsa-miR-4274 gene" or "hsa-miR-4 The term "miR-4274" refers to the hsa-miR-4274 gene (miRB) set forth in SEQ ID NO: 1. ase Accession No. MIMAT0016906) and other species homologues The hsa-miR-4274 gene is a member of the Goff According to the method described in LA et al., 2009, PLoS One., Vol. 4, e7192 In addition, "hsa-miR-4274" can be obtained by using hairpin as its precursor. The miRBase Accession No. 100001266666 (hsa-mir-4274) has a miR-like structure. No. MI0015884, SEQ ID NO: 391) is known.

[0079] As used herein, "hsa-miR-4272 gene" or "hsa-miR-4 The term "miR-4272" refers to the hsa-miR-4272 gene (miRB) set forth in SEQ ID NO: 2. ase Accession No. MIMAT0016902) and other species homologues The hsa-miR-4272 gene is a member of the Goff LA et al., 2009, PLoS One., Vol. 4, e7192. In addition, "hsa-miR-4272" can be obtained by using hairpin as its precursor. The miRBase Accession No. 100001266664444 (hsa-mir-4272) has a miR-like structure. No. MI0015880, SEQ ID NO: 392) is known.

[0080] As used herein, "hsa-miR-4728-5p gene" or "hsa-mi The term "miR-4728-5p" refers to hsa-miR-4728-5p as set forth in SEQ ID NO: 3. p gene (miRBase Accession No. MIMAT0019849) Other species homologs or orthologs are also included. hsa-miR-4728 The -5p gene is Persson H et al., 2011, Cancer Res., Vol. 71 , pp. 78-86. 728-5p is a precursor of hsa-mir-4728, which has a hairpin-like structure. ” (miRBase Accession No. MI0017365, SEQ ID NO: 393 ) is known.

[0081] As used herein, "hsa-miR-4443 gene" or "hsa-miR-4 The term "miR-4443" refers to the hsa-miR-4443 gene (miRB) set forth in SEQ ID NO: 4. ase Accession No. MIMAT0018961) and other species homologues The hsa-miR-4443 gene is a member of the Jima The method described in DD et al., 2010, Blood., Vol. 116, e118-e127 Furthermore, "hsa-miR-4443" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4443" (miRBase Accession No. on No. MI0016786, SEQ ID NO: 394) is known.

[0082] As used herein, "hsa-miR-4506 gene" or "hsa-miR-4 The term "miR-4506" refers to the hsa-miR-4506 gene (miRB) set forth in SEQ ID NO: 5. ase Accession No. MIMAT0019042) and other species homologues The hsa-miR-4506 gene is also included in the Jima The method described in DD et al., 2010, Blood., Vol. 116, e118-e127 Furthermore, "hsa-miR-4506" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-4506" (miRBase Accession No. on No. MI0016869, SEQ ID NO: 395) is known.

[0083] As used herein, "hsa-miR-6773-5p gene" or "hsa-mi The term "miR-6773-5p" refers to hsa-miR-6773-5p as set forth in SEQ ID NO: 6. p gene (miRBase Accession No. MIMAT0027446) Other species homologs or orthologs are also included. hsa-miR-6773 The -5p gene is Ladewig E et al., 2012, Genome Res., Vol. 22 , 1634-1645. iR-6773-5p is a precursor of the hairpin-like structure known as hsa-mir- 6773" (miRBase Accession No. MI0022618, sequence no. No. 396) is known.

[0084] As used herein, "hsa-miR-4662a-5p gene" or "hsa-m The term "miR-4662a-5p" refers to hsa-miR-4662a-5p as set forth in SEQ ID NO: 7. a-5p gene (miRBase Accession No. MIMAT001973 1) and other species homologs or orthologs. The 662a-5p gene is described in Persson H et al., 2011, Cancer Res. , vol. 71, pp. 78-86. iR-4662a-5p is a precursor of hsa-mir, which has a hairpin-like structure. -4662a” (miRBase Accession No. MI0017290, Column number 397) is known.

[0085] As used herein, "hsa-miR-3184-3p gene" or "hsa-mi The term "miR-3184-3p" refers to hsa-miR-3184-3p as set forth in SEQ ID NO: 8. p gene (miRBase Accession No. MIMAT0022731) Other species homologs or orthologs are also included. hsa-miR-3184 -3p gene, Stark MS et al., 2010, PLoS One., Vol. 5, e96 The miR-3184 gene can be obtained by the method described in 85. 3p" has a hairpin-like structure as its precursor "hsa-mir-3184" (mi RBase Accession No. MI0014226, sequence number 398) It is being done.

[0086] As used herein, "hsa-miR-4281 gene" or "hsa-miR-4 The term "miR-4281" refers to the hsa-miR-4281 gene (miRB) set forth in SEQ ID NO: 9. ase Accession No. MIMAT0016907) and other species homologues The hsa-miR-4281 gene is a member of the Goff LA et al., 2009, PLoS One., Vol. 4, e7192. In addition, "hsa-miR-4281" can be obtained by using hairpin as its precursor. The miRBase Accession No. 10 ... No. MI0015885, SEQ ID NO: 399) is known.

[0087] As used herein, "hsa-miR-320d gene" or "hsa-miR-3 The term "miR-320d" refers to the hsa-miR-320d gene (miR Base Accession No. MIMAT0006764) and other species of Homo sapiens The hsa-miR-320d gene is a miR-320d gene that encodes a miR-320d gene. Edlander MR et al., 2008, Nat Biotechnol., 26, 4 The "hsa-miR-3" can be obtained by the method described in JP 07-415. 20d" has a hairpin-like structure as its precursor, "hsa-mir-320d-1, hsa-mir-320d-2” (miRBase Accession No.MI0 008190, MI0008192, SEQ ID NOs: 400, 401) are known.

[0088] As used herein, "hsa-miR-6729-3p gene" or "hsa-mi The term "hsa-miR-6729-3p" refers to hsa-miR-6729-3p as set forth in SEQ ID NO: 11. 3p gene (miRBase Accession No. MIMAT0027360) hsa-miR-672 and other species homologs or orthologs. The 9-3p gene is Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6729-3p has a hairpin-like structure as its precursor, hsa-mir -6729" (miRBase Accession No. MI0022574, sequence Number 402) is known.

[0089] As used herein, "hsa-miR-5192 gene" or "hsa-miR-5 The term "miR-5192" refers to the hsa-miR-5192 gene (miR-5192) set forth in SEQ ID NO: 12. Base Accession No. MIMAT0021123) and other species of Homo sapiens The hsa-miR-5192 gene is a member of the Sch otte D et al., 2011, Leukemia., vol. 25, 1389-1399 hsa-miR-5192 can be obtained by the method described above. The miRBase Ac receptor has a hairpin-like structure as a carrier. Accession No. MI0018171, SEQ ID NO: 403) is known.

[0090] As used herein, "hsa-miR-6853-5p gene" or "hsa-mi The term "miR-6853-5p" refers to hsa-miR-6853-5p as set forth in SEQ ID NO: 13. 5p gene (miRBase Accession No. MIMAT0027606) hsa-miR-685 and other species homologs or orthologs. The 3-5p genes are described in Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6853-5p has a hairpin-like structure as its precursor, hsa-mir -6853" (miRBase Accession No. MI0022699, sequence Number 404) is known.

[0091] As used herein, the term "hsa-miR-1234-3p gene" or "hsa-mi The term "miR-1234-3p" refers to hsa-miR-1234-3p as set forth in SEQ ID NO: 14. 3p gene (miRBase Accession No. MIMAT0005589) hsa-miR-123 and other species homologs or orthologs. The 4-3p gene is described in Berezikov E et al., 2007, Mol Cell., 28 It can be obtained by the method described in Vol. 328-336. R-1234-3p is a precursor of hsa-mir-1, which has a hairpin-like structure. 234" (miRBase Accession No. MI0006324, SEQ ID NO: 405) is known.

[0092] As used herein, "hsa-miR-1233-3p gene" or "hsa-mi The term "miR-1233-3p" refers to hsa-miR-1233-3p as set forth in SEQ ID NO: 15. 3p gene (miRBase Accession No. MIMAT0005588) hsa-miR-123 and other species homologs or orthologs. The 3-3p gene is described in Berezikov E et al., 2007, Mol Cell., 28 It can be obtained by the method described in Vol. 328-336. R-1233-3p is a precursor of hsa-mir-1, which has a hairpin-like structure. 233-1, hsa-mir-1233-2” (miRBase Accession No. MI0006323, MI0015973, SEQ ID NO: 406, 407) are known. There are.

[0093] As used herein, "hsa-miR-4539 gene" or "hsa-miR-4 The term "miR-4539" refers to the hsa-miR-4539 gene (miR Base Accession No. MIMAT0019082) and other species of Homo sapiens The hsa-miR-4539 gene is a member of the Jim a) DD et al., 2010, Blood., Vol. 116, e118-e127 hsa-miR-4539 can be obtained by the method described above. The miRBase Accession No. 1006266666, which has a hairpin-like structure, is a missense mutation in the miR-1 gene. ion No. MI0016910, SEQ ID NO: 408) is known.

[0094] As used herein, "hsa-miR-3914 gene" or "hsa-miR-3 The term "miR-3914" refers to the hsa-miR-3914 gene (miR Base Accession No. MIMAT0018188) and other species of Homo sapiens The hsa-miR-3914 gene is expressed by Cre Lighton CJ et al., 2010, PLoS One., Vol. 5, e9637 Furthermore, "hsa-miR-3914" can be obtained by the method described above. The hairpin-like structures of hsa-mir-3914-1 and hsa-mir-391 4-2” (miRBase Accession No. MI0016419, MI00 16421, SEQ ID NOs: 409, 410) are known.

[0095] As used herein, "hsa-miR-4738-5p gene" or "hsa-mi The term "miR-4738-5p" refers to hsa-miR-4738-5p as set forth in SEQ ID NO: 18. 5p gene (miRBase Accession No. MIMAT0019866) hsa-miR-473 and other species homologs or orthologs. The 8-5p gene is Persson H et al., 2011, Cancer Res., 71 The miR-hsa gene can be obtained by the method described in Vol. 78-86. 4738-5p is a precursor of hsa-mir-473, which has a hairpin-like structure. 8" (miRBase Accession No. MI0017376, SEQ ID NO: 41 1) is known.

[0096] As used herein, "hsa-miR-548au-3p gene" or "hsa-m The term "miR-548au-3p" refers to hsa-miR-548 as set forth in SEQ ID NO: 19. The au-3p gene (miRBase Accession No. MIMAT00222 92) and other species homologs or orthologs. The 548au-3p gene is described in Friedlander MR et al., 2012, Nucle Acids Res., Vol. 40, 37-52. In addition, "hsa-miR-548au-3p" has a hairpin-like structure as its precursor. The structure of "hsa-mir-548au" (miRBase Accession No. o.MI0019145, SEQ ID NO: 412) is known.

[0097] As used herein, "hsa-miR-1539 gene" or "hsa-miR-1 The term "miR-1539" refers to the hsa-miR-1539 gene (miR Base Accession No. MIMAT0007401) and other species of Homo sapiens The hsa-miR-1539 gene is a member of the Azu family of miR-1539 genes. ma-Mukai A et al., 2008, Proc Natl Acad Sci US A., Vol. 105, pp. 7964-7969. In addition, "hsa-miR-1539" has a hairpin-like structure as its precursor, "hsa -mir-1539” (miRBase Accession No. MI000726 0, SEQ ID NO: 413) is known.

[0098] As used herein, "hsa-miR-4720-3p gene" or "hsa-mi The term "miR-4720-3p" refers to hsa-miR-4720-3p as set forth in SEQ ID NO: 21. 3p gene (miRBase Accession No. MIMAT0019834) hsa-miR-472 and other species homologs or orthologs. The 0-3p gene is Persson H et al., 2011, Cancer Res., 71 The miR-hsa gene can be obtained by the method described in Vol. 78-86. 4720-3p is a precursor of hsa-mir-472, which has a hairpin-like structure. 0" (miRBase Accession No. MI0017355, SEQ ID NO: 41 4) is known.

[0099] As used herein, the term "hsa-miR-365b-5p gene" or "hsa-mi The term "miR-365b-5p" refers to hsa-miR-365b-5p as set forth in SEQ ID NO: 22. 5p gene (miRBase Accession No. MIMAT0022833) hsa-miR-365 and other species homologs or orthologs. The b-5p gene is Xie X et al., 2005, Nature., Vol. 434, pp. 338-3 The miR-365b gene can be obtained by the method described in 45. 5p" has a hairpin-like structure as its precursor "hsa-mir-365b" (mi RBase Accession No. MI0000769, sequence number 415) It is being done.

[0100] As used herein, "hsa-miR-4486 gene" or "hsa-miR-4 The term "miR-4486" refers to the hsa-miR-4486 gene (miR Base Accession No. MIMAT0019020) and other species of Homo sapiens The hsa-miR-4486 gene is a member of the Jim a) DD et al., 2010, Blood., Vol. 116, e118-e127 hsa-miR-4486 can be obtained by the method described above. The miRBase Accession No. 100002606 (hsa-mir-4486) has a hairpin-like structure. ion No. MI0016847, SEQ ID NO: 416) is known.

[0101] As used herein, "hsa-miR-1227-5p gene" or "hsa-mi The term "miR-1227-5p" refers to hsa-miR-1227-5p as set forth in SEQ ID NO: 24. 5p gene (miRBase Accession No. MIMAT0022941) hsa-miR-122 and other species homologs or orthologs. The 7-5p gene is described in Berezikov E et al., 2007, Mol Cell., 28 It can be obtained by the method described in Vol. 328-336. R-1227-5p is a precursor of hsa-mir-1, which has a hairpin-like structure. 227" (miRBase Accession No. MI0006316, SEQ ID NO: 417) is known.

[0102] As used herein, "hsa-miR-4667-5p gene" or "hsa-mi The term "miR-4667-5p" refers to hsa-miR-4667-5p as set forth in SEQ ID NO: 25. 5p gene (miRBase Accession No. MIMAT0019743) hsa-miR-466 and other species homologs or orthologs. The 7-5p gene is Persson H et al., 2011, Cancer Res., 71 The miR-hsa gene can be obtained by the method described in Vol. 78-86. 4667-5p is a precursor of hsa-mir-466, which has a hairpin-like structure. 7" (miRBase Accession No. MI0017297, SEQ ID NO: 41 8) is known.

[0103] As used herein, "hsa-miR-6088 gene" or "hsa-miR-6 The term "miR-6088" refers to the hsa-miR-6088 gene (miR-6088) set forth in SEQ ID NO: 26. Base Accession No. MIMAT0023713) and other species of Homo sapiens The hsa-miR-6088 gene is a member of the Yoo JK et al., 2012, Stem Cells Dev., Vol. 21, 2049-2057 Furthermore, "hsa-miR-6088" can be obtained by the method described in Its precursor, "hsa-mir-6088" (miRBase Accession No. MI0020365, SEQ ID NO: 419) is known.

[0104] As used herein, "hsa-miR-6820-5p gene" or "hsa-mi The term "miR-6820-5p" refers to hsa-miR-6820-5p as set forth in SEQ ID NO: 27. 5p gene (miRBase Accession No. MIMAT0027540) hsa-miR-682 and other species homologs or orthologs. The 0-5p gene is Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6820-5p has a hairpin-like structure as its precursor, hsa-mir -6820" (miRBase Accession No. MI0022665, sequence Number 420) is known.

[0105] As used herein, "hsa-miR-4505 gene" or "hsa-miR-4 The term "miR-4505" refers to the hsa-miR-4505 gene (miR Base Accession No. MIMAT0019041) and other species of Homo sapiens The hsa-miR-4505 gene is a member of the Jim a) DD et al., 2010, Blood., Vol. 116, e118-e127 hsa-miR-4505 can be obtained by the method described above. The miRBase Accession No. 10000266666 (hsa-mir-4505) has a hairpin-like structure. ion No. MI0016868, SEQ ID NO: 421) is known.

[0106] As used herein, "hsa-miR-548q gene" or "hsa-miR-5 The term "miR-548q" refers to the hsa-miR-548q gene (miR Base Accession No. MIMAT0011163) and other species of Homo sapiens The hsa-miR-548q gene is a member of the Wym The method described in An SK et al., 2009, PLoS One., Vol. 4, e5311 hsa-miR-548q can be obtained by The apin-like structure of "hsa-mir-548q" (miRBase Accession No. 1001001001001) n No. MI0010637, sequence number 422) is known.

[0107] As used herein, "hsa-miR-4658 gene" or "hsa-miR-4 The term "miR-4658" refers to the hsa-miR-4658 gene (miR Base Accession No. MIMAT0019725) and other species of Homo sapiens The hsa-miR-4658 gene is a member of the Per sson H et al., 2011, Cancer Res., 71, 78-86 Furthermore, "hsa-miR-4658" can be obtained by the method described above. The miRBase Accession No. 100626 ... The sequence of the gene encoding the nucleotide sequence of the present invention is known to be nucleotide sequence no. MI0017286, sequence number 423.

[0108] As used herein, "hsa-miR-450a-5p gene" or "hsa-mi The term "miR-450a-5p" refers to hsa-miR-450a-5p as set forth in SEQ ID NO: 31. 5p gene (miRBase Accession No. MIMAT0001545) hsa-miR-450 and other species homologs or orthologs. The a-5p gene is Xie X et al., 2005, Nature., Vol. 434, pp. 338-3 45. Also, "hsa-miR-450a- 5p" has a hairpin-like structure as its precursor "hsa-mir-450a-1, h sa-mir-450a-2” (miRBase Accession No. MI00 01652, MI0003187, SEQ ID NOs: 424, 425) are known.

[0109] As used herein, "hsa-miR-1260b gene" or "hsa-miR- The term "miR-1260b" refers to the hsa-miR-1260b gene ( miRBase Accession No. MIMAT0015041) and other organisms The hsa-miR-1260b gene is a member of the family of miR-1260b. , Stark MS et al., 2010, PLoS One., Vol. 5, e9685 hsa-miR-1260b can be obtained by the method described above. The miRBase Ac Accession No. MI0014197, SEQ ID NO: 426) is known.

[0110] As used herein, "hsa-miR-3677-5p gene" or "hsa-mi The term "miR-3677-5p" refers to hsa-miR-3677-5p as set forth in SEQ ID NO: 33. 5p gene (miRBase Accession No. MIMAT0019221) hsa-miR-367 and other species homologs or orthologs. The 7-5p gene is Vaz C et al., 2010, BMC Genomics., Vol. 11, 288. Also, "hsa-miR-3677" can be obtained by the method described in -5p" has a hairpin-like structure as its precursor, "hsa-mir-3677" (m iRBase Accession No. MI0016078, sequence number 427) It is being done.

[0111] As used herein, "hsa-miR-6777-3p gene" or "hsa-mi The term "miR-6777-3p" refers to hsa-miR-6777-3p as set forth in SEQ ID NO: 34. 3p gene (miRBase Accession No. MIMAT0027455) hsa-miR-677 and other species homologs or orthologs. The 7-3p gene is Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6777-3p has a hairpin-like structure as its precursor, hsa-mir -6777" (miRBase Accession No. MI0022622, sequence Number 428) is known.

[0112] As used herein, "hsa-miR-6826-3p gene" or "hsa-mi The term "miR-6826-3p" refers to hsa-miR-6826-3p as set forth in SEQ ID NO: 35. 3p gene (miRBase Accession No. MIMAT0027553) hsa-miR-682 and other species homologs or orthologs. The 6-3p gene is Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6826-3p has a hairpin-like structure as its precursor, hsa-mir -6826" (miRBase Accession No. MI0022671, sequence Number 429) is known.

[0113] As used herein, "hsa-miR-6832-3p gene" or "hsa-mi The term "miR-6832-3p" refers to hsa-miR-6832-3p as set forth in SEQ ID NO: 36. 3p gene (miRBase Accession No. MIMAT0027565) and other species homologs or orthologs. The 2-3p genes are described in Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6832-3p has a hairpin-like structure as its precursor, hsa-mir -6832" (miRBase Accession No. MI0022677, sequence Number 430) is known.

[0114] As used herein, "hsa-miR-4725-3p gene" or "hsa-mi The term "miR-4725-3p" refers to hsa-miR-4725-3p as set forth in SEQ ID NO: 37. 3p gene (miRBase Accession No. MIMAT0019844) hsa-miR-472 and other species homologs or orthologs. The 5-3p gene is Persson H et al., 2011, Cancer Res., 71 The miR-hsa gene can be obtained by the method described in Vol. 78-86. 4725-3p is a precursor of hsa-mir-472, which has a hairpin-like structure. 5" (miRBase Accession No. MI0017362, SEQ ID NO: 43 1) is known.

[0115] As used herein, "hsa-miR-7161-3p gene" or "hsa-mi The term "hsa-miR-7161-3p" refers to hsa-miR-7161-3p as set forth in SEQ ID NO: 38. 3p gene (miRBase Accession No. MIMAT0028233) and other species homologs or orthologs. The 1-3p genes are described in Meunier J et al., 2013, Genome Res., 23 The miR-hsa gene can be obtained by the method described in Vol. 34-45. 7161-3p is a precursor of hsa-mir-716, which has a hairpin-like structure. 1" (miRBase Accession No. MI0023619, SEQ ID NO: 43 2) is known.

[0116] As used herein, "hsa-miR-2277-5p gene" or "hsa-mi The term "miR-2277-5p" refers to hsa-miR-2277- 5p gene (miRBase Accession No. MIMAT0017352) hsa-miR-227 and other species homologs or orthologs. The 7-5p gene is described in Nygaard S et al., 2009, BMC Med Genome CS., Vol. 2, p. 35. R-2277-5p is a precursor of hsa-mir-2, which has a hairpin-like structure. 277" (miRBase Accession No. MI0011284, SEQ ID NO: 433) is known.

[0117] As used herein, "hsa-miR-7110-3p gene" or "hsa-mi The term "hsa-miR-7110-3p" refers to hsa-miR-7110-3p as set forth in SEQ ID NO: 40. 3p gene (miRBase Accession No. MIMAT0028118) hsa-miR-711 and other species homologs or orthologs. The 0-3p gene is Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-7110-3p has a hairpin-like structure as its precursor, hsa-mir -7110" (miRBase Accession No. MI0022961, sequence Number 434) is known.

[0118] As used herein, "hsa-miR-4312 gene" or "hsa-miR-4 The term "miR-4312" refers to the hsa-miR-4312 gene (miR Base Accession No. MIMAT0016864) and other species of Homo sapiens The hsa-miR-4312 gene is a member of the Gof f By the method described in LA et al., 2009, PLoS One., Vol. 4, e7192 In addition, "hsa-miR-4312" can be obtained by The pin-like structure of "hsa-mir-4312" (miRBase Accession No. No. MI0015842, SEQ ID NO: 435) is known.

[0119] As used herein, "hsa-miR-4461 gene" or "hsa-miR-4 The term "miR-4461" refers to the hsa-miR-4461 gene (miR Base Accession No. MIMAT0018983) and other species of Homo sapiens The hsa-miR-4461 gene is a member of the Jim a) DD et al., 2010, Blood., Vol. 116, e118-e127 hsa-miR-4461 can be obtained by the method described above. The miRBase Accession No. 100126 ... ion No. MI0016807, SEQ ID NO: 436) is known.

[0120] As used herein, "hsa-miR-6766-5p gene" or "hsa-mi The term "miR-6766-5p" refers to hsa-miR-6766-5p as set forth in SEQ ID NO: 43. 5p gene (miRBase Accession No. MIMAT0027432) hsa-miR-676 and other species homologs or orthologs. The 6-5p gene is Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6766-5p has a hairpin-like structure as its precursor, hsa-mir -6766" (miRBase Accession No. MI0022611, sequence Number 437) is known.

[0121] As used herein, "hsa-miR-1266-3p gene" or "hsa-mi The term "miR-1266-3p" refers to hsa-miR-1266-3p as set forth in SEQ ID NO: 44. 3p gene (miRBase Accession No. MIMAT0026742) hsa-miR-126 and other species homologs or orthologs. The 6-3p gene is Morin RD et al., 2008, Genome Res., Vol. 18 and the like. -1266-3p is a precursor of hsa-mir-12, which has a hairpin-like structure. 66" (miRBase Accession No. MI0006403, SEQ ID NO: 4 38) is known.

[0122] As used herein, "hsa-miR-6729-5p gene" or "hsa-mi The term "miR-6729-5p" refers to hsa-miR-6729-5p as set forth in SEQ ID NO: 45. 5p gene (miRBase Accession No. MIMAT0027359) hsa-miR-672 and other species homologs or orthologs. The 9-5p gene is Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6729-5p has a hairpin-like structure as its precursor, hsa-mir -6729" (miRBase Accession No. MI0022574, sequence Number 402) is known.

[0123] As used herein, "hsa-miR-526b-3p gene" or "hsa-mi The term "hsa-miR-526b-3p" refers to hsa-miR-526b-3p as set forth in SEQ ID NO: 46. 3p gene (miRBase Accession No. MIMAT0002836) hsa-miR-526 and other species homologs or orthologs. The b-3p gene is described in Bentwich I et al., 2005, Nat Genet., 37 It can be obtained by the method described in Vol. 766-770. R-526b-3p is a precursor of hsa-mir-5, which has a hairpin-like structure. 26b" (miRBase Accession No. MI0003150, SEQ ID NO: 439) is known.

[0124] As used herein, "hsa-miR-519e-5p gene" or "hsa-mi The term "hsa-miR-519e-5p" refers to hsa-miR-519e- 5p gene (miRBase Accession No. MIMAT0002828) hsa-miR-519 and other species homologs or orthologs. The e-5p gene is described in Bentwich I et al., 2005, Nat Genet., 37 It can be obtained by the method described in Vol. 766-770. R-519e-5p is a precursor of hsa-mir-5, which has a hairpin-like structure. 19e" (miRBase Accession No. MI0003145, SEQ ID NO: 440) is known.

[0125] As used herein, "hsa-miR-512-5p gene" or "hsa-miR The term "miR-512-5p" refers to the hsa-miR-512-5p gene set forth in SEQ ID NO: 48. gene (miRBase Accession No. MIMAT0002822) and its It also includes homologs or orthologs from other species. Genes are as follows: Bentwich I et al., 2005, Nat Genet., 37, 76 The miR-51 gene can be obtained by the method described in US Pat. No. 6,770,670. 2-5p" has a hairpin-like structure as its precursor, "hsa-mir-512-1, hsa-mir-512-2” (miRBase Accession No. MI00 03140, MI0003141, SEQ ID NOs: 441, 442) are known.

[0126] As used herein, "hsa-miR-5088-5p gene" or "hsa-mi The term "hsa-miR-5088-5p" refers to hsa-miR-5088- 5p gene (miRBase Accession No. MIMAT0021080) hsa-miR-508 and other species homologs or orthologs. The 8-5p gene is Ding N et al., 2011, J Radiat Res., Vol. 52 The hsa-miR can be obtained by the method described in -5088-5p is a precursor of hsa-mir-50, which has a hairpin-like structure. 88" (miRBase Accession No. MI0017977, SEQ ID NO: 4 43) is known.

[0127] As used herein, "hsa-miR-1909-3p gene" or "hsa-mi The term "hsa-miR-1909-3p" refers to hsa-miR-1909- 3p gene (miRBase Accession No. MIMAT0007883) hsa-miR-190 and other species homologs or orthologs. The 9-3p gene is Bar M et al., 2008, Stem Cells., Vol. 26, No. 24 The "hsa-miR- 1909-3p is a precursor of hsa-mir-190, which has a hairpin-like structure. 9" (miRBase Accession No. MI0008330, SEQ ID NO: 44 4) is known.

[0128] As used herein, "hsa-miR-6511a-5p gene" or "hsa-m The term "hsa-miR-6511a-5p" refers to hsa-miR-6511a-5p as set forth in SEQ ID NO: 51. 1a-5p gene (miRBase Accession No. MIMAT00254 78) and other species homologs or orthologs. The 6511a-5p gene is Joyce CE et al., 2011, Hum Mol Gen et al., Vol. 20, pp. 4025-4040. "hsa-miR-6511a-5p" has a hairpin-like structure as its precursor " hsa-mir-6511a-1, hsa-mir-6511a-2, hsa-mir- 6511a-3, hsa-mir-6511a-4” (miRBase Accessi on No. MI0022223, MI0023564, MI0023565, MI00 23566, SEQ ID NOs: 445, 446, 447, 448) are known.

[0129] As used herein, "hsa-miR-4734 gene" or "hsa-miR-4 The term "miR-4734" refers to the hsa-miR-4734 gene (miR Base Accession No. MIMAT0019859) and other species of Homo sapiens The hsa-miR-4734 gene is a member of the Per sson H et al., 2011, Cancer Res., 71, 78-86 Furthermore, "hsa-miR-4734" can be obtained by the method described above. The miRBase Accession No. 1000012666666, which has a hairpin-like structure, is a nucleotide sequence of the miR-1 gene. The sequence of the gene encoding the nucleotide sequence of the present invention is known to be nucleotide sequence no. MI0017371, sequence number 449.

[0130] As used herein, "hsa-miR-936 gene" or "hsa-miR-93 The term "miR-936" refers to the hsa-miR-936 gene (miRBas) set forth in SEQ ID NO: 53. e Accession No. MIMAT0004979) and homologs in other species The hsa-miR-936 gene is described by Lui WO et al. , 2007, Cancer Res., Vol. 67, pp. 6031-6043 hsa-miR-936 can be obtained by The apin-like structure of "hsa-mir-936" (miRBase Accession No. No. MI0005758, SEQ ID NO: 450) is known.

[0131] As used herein, "hsa-miR-1249-3p gene" or "hsa-mi The term "miR-1249-3p" refers to hsa-miR-1249-3p as set forth in SEQ ID NO: 54. 3p gene (miRBase Accession No. MIMAT0005901) hsa-miR-124 and other species homologs or orthologs. The 9-3p gene is Morin RD et al., 2008, Genome Res., Vol. 18 and the like. -1249-3p is a precursor of hsa-mir-12, which has a hairpin-like structure. 49" (miRBase Accession No. MI0006384, SEQ ID NO: 4 51) is known.

[0132] As used herein, "hsa-miR-6777-5p gene" or "hsa-mi The term "miR-6777-5p" refers to hsa-miR-6777-5p as set forth in SEQ ID NO: 55. 5p gene (miRBase Accession No. MIMAT0027454) hsa-miR-677 and other species homologs or orthologs. The 7-5p gene is Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6777-5p has a hairpin-like structure as its precursor, hsa-mir -6777” (miRBase Accession No. MI0022622, Column number 428) is known.

[0133] As used herein, "hsa-miR-4487 gene" or "hsa-miR-4 The term "miR-4487" refers to the hsa-miR-4487 gene (miR Base Accession No. MIMAT0019021) and other species of Homo sapiens The hsa-miR-4487 gene is a member of the Jim a) DD et al., 2010, Blood., Vol. 116, e118-e127 hsa-miR-4487 can be obtained by the method described above. The miRBase Accession No. 1000020 ... ion No. MI0016848, SEQ ID NO: 452) is known.

[0134] As used herein, "hsa-miR-3155a gene" or "hsa-miR- The term "miR-3155a" refers to the hsa-miR-3155a gene ( miRBase Accession No. MIMAT0015029) and other organisms The hsa-miR-3155a gene is a member of the family of miR-3155a. , Stark MS et al., 2010, PLoS One., Vol. 5, e9685 hsa-miR-3155a can be obtained by the method described above. The miRBase Ac Accession No. MI0014183, SEQ ID NO: 453) is known.

[0135] As used herein, "hsa-miR-563 gene" or "hsa-miR-56 The term "miR-563" refers to the hsa-miR-563 gene (miRBas) set forth in SEQ ID NO: 58. e Accession No. MIMAT0003227) and homologs in other species The hsa-miR-563 gene is a member of the Cummins JM et al., 2006, Proc Natl Acad Sci U S A., 103 It can be obtained by the method described in Vol. 3687-3692. miR-563 has a hairpin-like structure as its precursor, hsa-mir-563 ” (miRBase Accession No. MI0003569, SEQ ID NO: 454 ) is known.

[0136] As used herein, "hsa-miR-4741 gene" or "hsa-miR-4 The term "miR-4741" refers to the hsa-miR-4741 gene (miR Base Accession No. MIMAT0019871) and other species of Homo sapiens The hsa-miR-4741 gene is a member of the Per sson H et al., 2011, Cancer Res., 71, 78-86 Furthermore, "hsa-miR-4741" can be obtained by the method described above. The miRBase Accession No. 100012666644 (hsa-mir-4741) has a hairpin-like structure as a The sequence number of the gene encoding the nucleotide sequence of the present invention is 455 (sequence number MI0017379).

[0137] As used herein, "hsa-miR-6788-5p gene" or "hsa-mi The term "miR-6788-5p" refers to hsa-miR-6788-5p as set forth in SEQ ID NO: 60. 5p gene (miRBase Accession No. MIMAT0027476) hsa-miR-678 and other species homologs or orthologs. The 8-5p gene is Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6788-5p has a hairpin-like structure as its precursor, hsa-mir -6788" (miRBase Accession No. MI0022633, sequence Number 456) is known.

[0138] As used herein, "hsa-miR-4433b-5p gene" or "hsa-m The term "miR-4433b-5p" refers to hsa-miR-4433b-5p as set forth in SEQ ID NO: 61. 3b-5p gene (miRBase Accession No. MIMAT00304 13) and other species homologs or orthologs. The 4433b-5p gene is Ple H et al., 2012, PLoS One., Vol. 7, e The miR-44 gene can be obtained by the method described in 50746. 33b-5p has a hairpin-like structure as its precursor, hsa-mir-4433 b" (miRBase Accession No. MI0025511, SEQ ID NO: 45 7) is known.

[0139] As used herein, "hsa-miR-323a-5p gene" or "hsa-mi The term "miR-323a-5p" refers to hsa-miR-323a-5p as set forth in SEQ ID NO: 62. 5p gene (miRBase Accession No. MIMAT0004696) hsa-miR-323 and other species homologs or orthologs. The a-5p gene is described in Kim J et al., 2004, Proc Natl Acad Sci US A., Vol. 101, pp. 360-365 In addition, "hsa-miR-323a-5p" has a hairpin-like structure as its precursor. The miRBase Accession No. MI0 000807, SEQ ID NO: 458) is known.

[0140] As used herein, "hsa-miR-6811-5p gene" or "hsa-mi The term "hsa-miR-6811-5p" refers to hsa-miR-6811-5p as set forth in SEQ ID NO: 63. 5p gene (miRBase Accession No. MIMAT0027522) hsa-miR-681 and other species homologs or orthologs. The 1-5p gene is Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6811-5p has a hairpin-like structure as its precursor, hsa-mir -6811" (miRBase Accession No. MI0022656, sequence Number 459) is known.

[0141] As used herein, "hsa-miR-6721-5p gene" or "hsa-mi The term "miR-6721-5p" refers to hsa-miR-6721-5p as set forth in SEQ ID NO: 64. 5p gene (miRBase Accession No. MIMAT0025852) hsa-miR-672 and other species homologs or orthologs. The 1-5p gene is described in Li Y et al., 2012, Gene., Vol. 497, 330-335. The "hsa-miR-6721-5p" can be obtained by the method described in the specification. The precursor of miRBa is a hairpin-like structure called "hsa-mir-6721" (miRBa (Accession No. MI0022556, SEQ ID NO: 460) do.

[0142] As used herein, "hsa-miR-5004-5p gene" or "hsa-mi The term "miR-5004-5p" refers to hsa-miR-5004-5p as set forth in SEQ ID NO: 65. 5p gene (miRBase Accession No. MIMAT0021027) hsa-miR-500 and other species homologs or orthologs. The 4-5p genes are Hansen TB et al., 2011, RNA Biol., Vol. 8, No. 3 78-383. 004-5p has a hairpin-like structure as its precursor, hsa-mir-5004 ” (miRBase Accession No. MI0017870, SEQ ID NO: 461 ) is known.

[0143] As used herein, "hsa-miR-6509-3p gene" or "hsa-mi The term "hsa-miR-6509-3p" refers to hsa-miR-6509-3p as set forth in SEQ ID NO: 66. 3p gene (miRBase Accession No. MIMAT0025475) hsa-miR-650 and other species homologs or orthologs. The 9-3p gene is described in Joyce CE et al., 2011, Hum Mol Genet. 20, pp. 4025-4040. a-miR-6509-3p has a hairpin-like structure as its precursor, hsa-m ir-6509” (miRBase Accession No. MI0022221, SEQ ID NO: 462) is known.

[0144] As used herein, "hsa-miR-648 gene" or "hsa-miR-64 The term "miR-648" refers to the hsa-miR-648 gene (miRBas) set forth in SEQ ID NO: 67. e Accession No. MIMAT0003318) and homologs in other species The hsa-miR-648 gene is a member of the Cummins JM et al., 2006, Proc Natl Acad Sci U S A., 103 It can be obtained by the method described in Vol. 3687-3692. miR-648 has a hairpin-like structure as its precursor, hsa-mir-648 ” (miRBase Accession No. MI0003663, SEQ ID NO: 463 ) is known.

[0145] As used herein, "hsa-miR-3917 gene" or "hsa-miR-3 The term "miR-3917" refers to the hsa-miR-3917 gene (miR Base Accession No. MIMAT0018191) and other species of Homo sapiens The hsa-miR-3917 gene is expressed by Cre Lighton CJ et al., 2010, PLoS One., Vol. 5, e9637 Furthermore, "hsa-miR-3917" can be obtained by the method described above. The miRBase Accession No. 10000126634444444 has a hairpin-like structure as a target protein, "hsa-mir-3917" (miRBase Accession No. 100001266344444444). The sequence of the gene encoding the nucleotide sequence of the present invention is known to be nucleotide sequence no. MI0016423, sequence number 464.

[0146] As used herein, "hsa-miR-6087 gene" or "hsa-miR-6 The term "miR-6087" refers to the hsa-miR-6087 gene (miR-6087) set forth in SEQ ID NO: 69. Base Accession No. MIMAT0023712) and other species of Homo sapiens The hsa-miR-6087 gene is a member of the Yoo JK et al., 2012, Stem Cells Dev., Vol. 21, 2049-2057 Furthermore, "hsa-miR-6087" can be obtained by the method described in Its precursor, "hsa-mir-6087" (miRBase Accession No. MI0020364, SEQ ID NO: 465) is known.

[0147] As used herein, "hsa-miR-1470 gene" or "hsa-miR-1 The term "miR-1470" refers to the hsa-miR-1470 gene (miR-1470) set forth in SEQ ID NO: 70. Base Accession No. MIMAT0007348) and other species of Homo sapiens The hsa-miR-1470 gene is a member of the Kaw Aji H et al., 2008, BMC Genomics., Vol. 9, No. 157 hsa-miR-1470 can be obtained by the method described above. The miRBase Accession No. 100002666666 (hsa-mir-1470) has a hairpin-like structure. ion No. MI0007075, SEQ ID NO: 466) is known.

[0148] As used herein, "hsa-miR-586 gene" or "hsa-miR-58 The term "miR-586" refers to the hsa-miR-586 gene (miRBas) set forth in SEQ ID NO: 71. e Accession No. MIMAT0003252) and homologs in other species The hsa-miR-586 gene is a member of the Cummins JM et al., 2006, Proc Natl Acad Sci U S A., 103 It can be obtained by the method described in Vol. 3687-3692. miR-586 has a hairpin-like structure as its precursor, hsa-mir-586 ” (miRBase Accession No. MI0003594, SEQ ID NO: 467 ) is known.

[0149] As used herein, "hsa-miR-3150a-5p gene" or "hsa-m The term "hsa-miR-3150a-5p" refers to hsa-miR-3150a-5p as set forth in SEQ ID NO: 72. 0a-5p gene (miRBase Accession No. MIMAT00192 06) and other species homologs or orthologs. The 3150a-5p gene is described in Stark MS et al., 2010, PLoS One., 5 The miR-hsa gene can be obtained by the method described in Vol. 3150a-5p is a precursor of hsa-mir-31, which has a hairpin-like structure. 50a" (miRBase Accession No. MI0014177, SEQ ID NO: 468) is known.

[0150] As used herein, "hsa-miR-105-3p gene" or "hsa-miR The term "miR-105-3p" refers to the hsa-miR-105-3p gene set forth in SEQ ID NO: 73. gene (miRBase Accession No. MIMAT0004516) and its It also includes homologs or orthologs from other species. Genes are described in Mourelatos Z et al., 2002, Genes Dev., Vol. 16, The "hsa-miR- 105-3p has a hairpin-like structure as its precursor, hsa-mir-105- 1, hsa-mir-105-2” (miRBase Accession No. MI 0000111, MI0000112, SEQ ID NOs: 469, 470) are known.

[0151] As used herein, "hsa-miR-7973 gene" or "hsa-miR-7 The term "miR-7973" refers to the hsa-miR-7973 gene (miR Base Accession No. MIMAT0031176) and other species of Homo sapiens The hsa-miR-7973 gene is a member of the Vel Thut-Meikas A et al., 2013, Mol Endocrinol., Vol. 27 , 1128-1141. iR-7973 has a hairpin-like structure as its precursor, hsa-mir-797 3-1, hsa-mir-7973-2” (miRBase Accession No. .MI0025748, MI0025749, sequence numbers 471 and 472) are known .

[0152] As used herein, "hsa-miR-1914-5p gene" or "hsa-mi The term "hsa-miR-1914-5p" refers to hsa-miR-1914- 5p gene (miRBase Accession No. MIMAT0007889) hsa-miR-191 and other species homologs or orthologs. The 4-5p gene is Bar M et al., 2008, Stem Cells., Vol. 26, No. 24 The "hsa-miR- 1914-5p is a precursor of hsa-mir-191, which has a hairpin-like structure. 4" (miRBase Accession No. MI0008335, SEQ ID NO: 47 3) is known.

[0153] As used herein, "hsa-miR-4749-3p gene" or "hsa-mi The term "miR-4749-3p" refers to hsa-miR-4749-3p as set forth in SEQ ID NO: 76. 3p gene (miRBase Accession No. MIMAT0019886) hsa-miR-474 and other species homologs or orthologs. The 9-3p gene is Persson H et al., 2011, Cancer Res., 71 The miR-hsa gene can be obtained by the method described in Vol. 78-86. 4749-3p is a precursor of hsa-mir-474, which has a hairpin-like structure. 9" (miRBase Accession No. MI0017388, SEQ ID NO: 47 4) is known.

[0154] As used herein, "hsa-miR-15b-5p gene" or "hsa-miR The term "miR-15b-5p" refers to the hsa-miR-15b-5p gene set forth in SEQ ID NO: 77. gene (miRBase Accession No. MIMAT0000417) and its It also includes homologs or orthologs from other species. The gene is from Lagos-Quintana M et al., 2002, Curr Biol., 12, pp. 735-739. miR-15b-5p has a hairpin-like structure as its precursor, hsa-mir- 15b" (miRBase Accession No. MI0000438, SEQ ID NO: 475) is known.

[0155] As used herein, "hsa-miR-1289 gene" or "hsa-miR-1 The term "miR-1289" refers to the hsa-miR-1289 gene (miR Base Accession No. MIMAT0005879) and other species of Homo sapiens The hsa-miR-1289 gene is a member of the Mor In RD et al., 2008, Genome Res., Vol. 18, 610-621 hsa-miR-1289 can be obtained by the method described above. The hairpin-like structures of hsa-mir-1289-1 and hsa-mir-12 89-2” (miRBase Accession No. MI0006350, MI0 006351, SEQ ID NOs: 476, 477) are known.

[0156] As used herein, "hsa-miR-4433a-5p gene" or "hsa-m The term "hsa-miR-4433a-5p" refers to hsa-miR-4433a-5p as set forth in SEQ ID NO: 79. 3a-5p gene (miRBase Accession No. MIMAT00209 56) and other species homologs or orthologs. The 4433a-5p gene is described in Jima DD et al., 2010, Blood., Vol. 116, It can be obtained by the method described in E118-E127. R-4433a-5p is a precursor of hsa-mir- 4433a" (miRBase Accession No. MI0016773, sequence Number 478) is known.

[0157] As used herein, "hsa-miR-3666 gene" or "hsa-miR-3 The term "miR-3666" refers to the hsa-miR-3666 gene (miR-3666) set forth in SEQ ID NO: 80. Base Accession No. MIMAT0018088) and other species of Homo sapiens The hsa-miR-3666 gene is involved in the regulation of Xie X et al., 2005, Nature., Vol. 434, 338-345. In addition, "hsa-miR-3666" can be obtained by The pin-like structure of "hsa-mir-3666" (miRBase Accession No. No. MI0016067, SEQ ID NO: 479) is known.

[0158] As used herein, "hsa-miR-3186-3p gene" or "hsa-mi The term "hsa-miR-3186-3p" refers to hsa-miR-3186- 3p gene (miRBase Accession No. MIMAT0015068) hsa-miR-318 and other species homologs or orthologs. The 6-3p gene is Creighton CJ et al., 2010, PLoS One., 5 The miR-hsa gene can be obtained by the method described in Vol. 3186-3p is a precursor of hsa-mir-318, which has a hairpin-like structure. 6" (miRBase Accession No. MI0014229, SEQ ID NO: 48 0) is known.

[0159] As used herein, "hsa-miR-4725-5p gene" or "hsa-mi The term "miR-4725-5p" refers to hsa-miR-4725-5p as set forth in SEQ ID NO: 82. 5p gene (miRBase Accession No. MIMAT0019843) hsa-miR-472 and other species homologs or orthologs. The 5-5p gene is Persson H et al., 2011, Cancer Res., 71 The miR-hsa gene can be obtained by the method described in Vol. 78-86. 4725-5p is a precursor of hsa-mir-472, which has a hairpin-like structure. 5" (miRBase Accession No. MI0017362, SEQ ID NO: 4 31) is known.

[0160] As used herein, "hsa-miR-4488 gene" or "hsa-miR-4 The term "miR-4488" refers to the hsa-miR-4488 gene (miR Base Accession No. MIMAT0019022) and other species of Homo sapiens The hsa-miR-4488 gene is a member of the Jim a) DD et al., 2010, Blood., Vol. 116, e118-e127 hsa-miR-4488 can be obtained by the method described above. The miRBase Accession No. 10062666666 (hsa-mir-4488) forms a hairpin-like structure. ion No. MI0016849, SEQ ID NO: 481) is known.

[0161] As used herein, "hsa-miR-4474-3p gene" or "hsa-mi The term "miR-4474-3p" refers to hsa-miR-4474-3p as set forth in SEQ ID NO: 84. 3p gene (miRBase Accession No. MIMAT0019001) hsa-miR-447 and other species homologs or orthologs. The 4-3p gene is described in Jima DD et al., 2010, Blood., Vol. 116, e118 The miR-44 gene can be obtained by the method described in Ref. "74-3p" has a hairpin-like structure as its precursor "hsa-mir-4474" (miRBase Accession No. MI0016826, SEQ ID NO: 482) is known.

[0162] As used herein, "hsa-miR-6731-3p gene" or "hsa-mi The term "miR-6731-3p" refers to hsa-miR-6731-3p as set forth in SEQ ID NO: 85. 3p gene (miRBase Accession No. MIMAT0027364) hsa-miR-673 and other species homologs or orthologs. The 1-3p genes are described in Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6731-3p has a hairpin-like structure as its precursor, hsa-mir -6731" (miRBase Accession No. MI0022576, sequence Number 483) is known.

[0163] As used herein, "hsa-miR-4640-3p gene" or "hsa-mi The term "miR-4640-3p" refers to hsa-miR-4640-3p as set forth in SEQ ID NO: 86. 3p gene (miRBase Accession No. MIMAT0019700) hsa-miR-464 and other species homologs or orthologs. The 0-3p gene is Persson H et al., 2011, Cancer Res., 71 The miR-hsa gene can be obtained by the method described in Vol. 78-86. 4640-3p is a precursor of hsa-mir-464, which has a hairpin-like structure. 0" (miRBase Accession No. MI0017267, SEQ ID NO: 48 4) is known.

[0164] As used herein, "hsa-miR-202-5p gene" or "hsa-miR The term "miR-202-5p" refers to the hsa-miR-202-5p gene set forth in SEQ ID NO: 87. gene (miRBase Accession No. MIMAT0002810) and its It also includes homologs or orthologs from other species. Genes are as follows: Bentwich I et al., 2005, Nat Genet., 37, 76 The "hsa-miR-20" can be obtained by the method described in US Pat. No. 6,770,670. 2-5p" has a hairpin-like structure as its precursor, "hsa-mir-202" (m iRBase Accession No. MI0003130, sequence number 485) It is being done.

[0165] As used herein, "hsa-miR-6816-5p gene" or "hsa-mi The term "miR-6816-5p" refers to hsa-miR-6816-5p as set forth in SEQ ID NO: 88. 5p gene (miRBase Accession No. MIMAT0027532) hsa-miR-681 and other species homologs or orthologs. The 6-5p gene is Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6816-5p has a hairpin-like structure as its precursor, hsa-mir -6816" (miRBase Accession No. MI0022661, sequence Number 486) is known.

[0166] As used herein, "hsa-miR-638 gene" or "hsa-miR-63 The term "miR-638" refers to the hsa-miR-638 gene (miRBas) set forth in SEQ ID NO: 89. e Accession No. MIMAT0003308) and homologs in other species The hsa-miR-638 gene is a member of the Cummins JM et al., 2006, Proc Natl Acad Sci U S A., 103 It can be obtained by the method described in Vol. 3687-3692. miR-638 has a hairpin-like structure as its precursor, hsa-mir-638 ” (miRBase Accession No. MI0003653, SEQ ID NO: 487 ) is known.

[0167] As used herein, "hsa-miR-6821-5p gene" or "hsa-mi The term "hsa-miR-6821-5p" refers to hsa-miR-6821-5p as set forth in SEQ ID NO: 90. 5p gene (miRBase Accession No. MIMAT0027542) hsa-miR-682 and other species homologs or orthologs. The 1-5p gene is Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6821-5p has a hairpin-like structure as its precursor, hsa-mir -6821" (miRBase Accession No. MI0022666, sequence Number 488) is known.

[0168] As used herein, the term "hsa-miR-1247-3p gene" or "hsa-mi The term "miR-1247-3p" refers to hsa-miR-1247-3p as set forth in SEQ ID NO: 91. 3p gene (miRBase Accession No. MIMAT0022721) hsa-miR-124 and other species homologs or orthologs. The 7-3p gene is Morin RD et al., 2008, Genome Res., Vol. 18 and the like. -1247-3p is a precursor of hsa-mir-12, which has a hairpin-like structure. 47" (miRBase Accession No. MI0006382, SEQ ID NO: 4 89) is known.

[0169] As used herein, "hsa-miR-6765-5p gene" or "hsa-mi The term "miR-6765-5p" refers to hsa-miR-6765-5p as set forth in SEQ ID NO: 92. 5p gene (miRBase Accession No. MIMAT0027430) hsa-miR-676 and other species homologs or orthologs. The 5-5p gene is Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6765-5p has a hairpin-like structure as its precursor, hsa-mir -6765" (miRBase Accession No. MI0022610, sequence Number 490) is known.

[0170] As used herein, "hsa-miR-6800-5p gene" or "hsa-mi The term "miR-6800-5p" refers to the miR-6800-5p described in SEQ ID NO: 93. 5p gene (miRBase Accession No. MIMAT0027500) hsa-miR-680 and other species homologs or orthologs. The 0-5p gene is Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6800-5p has a hairpin-like structure as its precursor, hsa-mir -6800" (miRBase Accession No. MI0022645, sequence Number 491) is known.

[0171] As used herein, the term "hsa-miR-3928-3p gene" or "hsa-mi The term "miR-3928-3p" refers to hsa-miR-3928- 3p gene (miRBase Accession No. MIMAT0018205) hsa-miR-392 and other species homologs or orthologs. The 8-3p gene is Creighton CJ et al., 2010, PLoS One., 5 The miR-hsa gene can be obtained by the method described in Vol. 3928-3p is a precursor of hsa-mir-392, which has a hairpin-like structure. 8" (miRBase Accession No. MI0016438, SEQ ID NO: 49 2) is known.

[0172] As used herein, "hsa-miR-3940-5p gene" or "hsa-mi The term "miR-3940-5p" refers to hsa-miR-3940-5p as set forth in SEQ ID NO: 95. 5p gene (miRBase Accession No. MIMAT0019229) hsa-miR-394 and other species homologs or orthologs. The 0-5p gene is Liao JY et al., 2010, PLoS One., Vol. 5, e10 563. Also, "hsa-miR-3940" can be obtained by the method described in -5p" has a hairpin-like structure as its precursor, "hsa-mir-3940" (m iRBase Accession No. MI0016597, sequence number 493) It is being done.

[0173] As used herein, "hsa-miR-3960 gene" or "hsa-miR-3 The term "miR-3960" refers to the hsa-miR-3960 gene (miR Base Accession No. MIMAT0019337) and other species of Homo sapiens The hsa-miR-3960 gene is a member of the Hu R et al., 2011, J Biol Chem., vol. 286, 12328-12339 hsa-miR-3960 can be obtained by the method described in the The precursor of "hsa-mir-3960" (miRBase A Accession No. MI0016964, SEQ ID NO: 494) is known.

[0174] As used herein, "hsa-miR-6775-5p gene" or "hsa-mi The term "miR-6775-5p" refers to hsa-miR-6775- 5p gene (miRBase Accession No. MIMAT0027450) hsa-miR-677 and other species homologs or orthologs. The 5-5p gene is Ladewig E et al., 2012, Genome Res., 22 It can be obtained by the method described in Vol. 1634-1645. miR-6775-5p has a hairpin-like structure as its precursor, hsa-mir -6775" (miRBase Accession No. MI0022620, sequence Number 495) is known.

[0175] As used herein, "hsa-miR-3178 gene" or "hsa-miR-3 The term "miR-3178" refers to the hsa-miR-3178 gene (miR-3178) set forth in SEQ ID NO: 98. Base Accession No. MIMAT0015055) and other species of Homo sapiens The hsa-miR-3178 gene is a member of the Sta rk MS et al., 2010, PLoS One., Vol. 5, e9685 hsa-miR-3178 can be obtained by The miRBase Accession No. hsa-mir-3178 (hsa-mir-3178) has an apin-like structure. n No. MI0014212, sequence number 496) is known.

[0176] As used herein, "hsa-miR-1202 gene" or "hsa-miR-1 The term "miR-1202" refers to the hsa-miR-1202 gene (miR-1202) set forth in SEQ ID NO: 99. Base Accession No. MIMAT0005865) and other species of Homo sapiens The hsa-miR-1202 gene is a member of the Mar ton S et al., 2008, Leukemia., vol. 22, 330-338 hsa-miR-1202 can be obtained by the method described above. The miRBase Accession No. 1202 (hsa-mir-1202) forms a hairpin-like structure. sion No. MI0006334, SEQ ID NO: 497) is known.

[0177] As used herein, "hsa-miR-6790-5p gene" or "hsa-mi The term "miR-6790-5p" refers to hsa-miR-6790 set forth in SEQ ID NO: 100. -5p gene (miRBase Accession No. MIMAT0027480 ) and other species homologs or orthologs. The 90-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6790-5p has a hairpin-like structure as its precursor, "hsa-mi r-6790" (miRBase Accession No. MI0022635, Column number 498) is known.

[0178] As used herein, "hsa-miR-4731-3p gene" or "hsa-mi The term "miR-4731-3p" refers to hsa-miR-4731 set forth in SEQ ID NO: 101. -3p gene (miRBase Accession No. MIMAT0019854 ) and other species homologs or orthologs. The 31-3p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4731-3p is a precursor of hsa-mir-47, which has a hairpin-like structure. 31" (miRBase Accession No. MI0017368, SEQ ID NO: 4 99) is known.

[0179] As used herein, "hsa-miR-2681-3p gene" or "hsa-mi The term "miR-2681-3p" refers to hsa-miR-2681 set forth in SEQ ID NO: 102. -3p gene (miRBase Accession No. MIMAT0013516 ) and other species homologs or orthologs. The 81-3p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -2681-3p is a precursor of hsa-mir-26, which has a hairpin-like structure. 81" (miRBase Accession No. MI0012062, SEQ ID NO: 5 00) is known.

[0180] As used herein, "hsa-miR-6758-5p gene" or "hsa-mi The term "miR-6758-5p" refers to hsa-miR-6758 as set forth in SEQ ID NO: 103. -5p gene (miRBase Accession No. MIMAT0027416 ) and other species homologs or orthologs. The 58-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6758-5p has a hairpin-like structure as its precursor, "hsa-mi r-6758” (miRBase Accession No. MI0022603, Column number 501) is known.

[0181] As used herein, "hsa-miR-8072 gene" or "hsa-miR-8 The term "miR-8072" refers to the hsa-miR-8072 gene (miR-8072) set forth in SEQ ID NO: 104. RBase Accession No. MIMAT0030999) and other species The hsa-miR-8072 gene is a homologue or ortholog. The method described in ng HJ et al., 2013, Shock., Vol. 39, pp. 480-487 hsa-miR-8072 can be obtained as a precursor of hsa-miR-8072. The miRBase Accession No. 1244444 (hsa-mir-8072) has an apin-like structure. n No. MI0025908, sequence number 502) is known.

[0182] As used herein, "hsa-miR-518d-3p gene" or "hsa-mi The term "hsa-miR-518d-3p" refers to hsa-miR-518d as set forth in SEQ ID NO: 105. -3p gene (miRBase Accession No. MIMAT0002864 ) and other species homologs or orthologs. The 8d-3p gene is described in Bentwich I et al., 2005, Nat Genet., 3 7, pp. 766-770. iR-518d-3p is a precursor of the hairpin-like structure known as hsa-mir- 518d" (miRBase Accession No. MI0003171, sequence no. No. 503) is known.

[0183] As used herein, the term "hsa-miR-3606-3p gene" or "hsa-mi The term "miR-3606-3p" refers to hsa-miR-3606 as set forth in SEQ ID NO: 106. -3p gene (miRBase Accession No. MIMAT0022965 ) and other species homologs or orthologs. The 06-3p gene is described in Witten D et al., 2010, BMC Biol., Vol. 8, No. 5 8. Also, "hsa-miR-3606-3 p” has a hairpin-like structure as its precursor “hsa-mir-3606” (miR Base Accession No. MI0015996, SEQ ID NO: 504) is known are.

[0184] As used herein, "hsa-miR-4800-5p gene" or "hsa-mi The term "miR-4800-5p" refers to the hsa-miR-4800 protein set forth in SEQ ID NO: 107. -5p gene (miRBase Accession No. MIMAT0019978 ) and other species homologs or orthologs. The 00-5p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4800-5p is a precursor of hsa-mir-48, which has a hairpin-like structure. 00" (miRBase Accession No. MI0017448, SEQ ID NO: 5 05) is known.

[0185] As used herein, the term "hsa-miR-1292-3p gene" or "hsa-mi The term "miR-1292-3p" refers to hsa-miR-1292 as set forth in SEQ ID NO: 108. -3p gene (miRBase Accession No. MIMAT0022948 ) and other species homologs or orthologs. The 92-3p gene is Morin RD et al., 2008, Genome Res., 18 It can be obtained by the method described in Vol. 610-621. R-1292-3p is a precursor of hsa-mir-1, which has a hairpin-like structure. 292" (miRBase Accession No. MI0006433, SEQ ID NO: 506) is known.

[0186] As used herein, "hsa-miR-6784-3p gene" or "hsa-mi The term "miR-6784-3p" refers to hsa-miR-6784 set forth in SEQ ID NO: 109. -3p gene (miRBase Accession No. MIMAT0027469 ) and other species homologs or orthologs. The 84-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6784-3p has a hairpin-like structure as its precursor, "hsa-mi r-6784" (miRBase Accession No. MI0022629, Column number 507) is known.

[0187] As used herein, "hsa-miR-4450 gene" or "hsa-miR-4 The term "miR-4450" refers to the hsa-miR-4450 gene (miR-4450) set forth in SEQ ID NO: 110. RBase Accession No. MIMAT0018971) and other species The hsa-miR-4450 gene is a homologue or ortholog of the Ji Ma DD et al., 2010, Blood., Vol. 116, e118-e127 hsa-miR-4450 can be obtained by the method described above. The miRBase Accession No. 1000226666445 forms a hairpin-like structure. sion No. MI0016795, SEQ ID NO: 508) is known.

[0188] As used herein, "hsa-miR-6132 gene" or "hsa-miR-6 The term "miR-6132" refers to the hsa-miR-6132 gene (miR-6132) set forth in SEQ ID NO: 111. RBase Accession No. MIMAT0024616) and other species The hsa-miR-6132 gene is a homologue or ortholog. Nnemann M et al., 2012, Genome Biol Evol., vol. 4, 55 2-564. 32” has a hairpin-like structure as its precursor, “hsa-mir-6132” (mi RBase Accession No. MI0021277, sequence number 509) It is being done.

[0189] As used herein, "hsa-miR-4716-5p gene" or "hsa-mi The term "miR-4716-5p" refers to hsa-miR-4716 as set forth in SEQ ID NO: 112. -5p gene (miRBase Accession No. MIMAT0019826 ) and other species homologs or orthologs. The 16-5p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4716-5p is a precursor of hsa-mir-47, which has a hairpin-like structure. 16" (miRBase Accession No. MI0017350, SEQ ID NO: 5 10) is known.

[0190] As used herein, "hsa-miR-6860 gene" or "hsa-miR-6 The term "miR-6860" refers to the hsa-miR-6860 gene (mi RBase Accession No. MIMAT0027622) and other species The hsa-miR-6860 gene is a homologue or ortholog. Dewig E et al., 2012, Genome Res., vol. 22, 1634-1645 Furthermore, "hsa-miR-6860" can be obtained by the method described in Its precursor, "hsa-mir-6860" (miRBase Accession No. MI0022707, SEQ ID NO: 511) is known.

[0191] As used herein, "hsa-miR-1268b gene" or "hsa-miR- The term "miR-1268b" refers to the hsa-miR-1268b gene set forth in SEQ ID NO: 114. (miRBase Accession No. MIMAT0018925) and other Species homologs or orthologs are included. hsa-miR-1268b gene This is reported in Jima DD et al., 2010, Blood., Vol. 116, e118-e127. hsa-miR-1268b can be obtained by the method described in the literature. The precursor of the miR gene, hsa-mir-1268b (miRBase Accession No. MI0016748, SEQ ID NO: 512) is known.

[0192] As used herein, "hsa-miR-378d gene" or "hsa-miR-3 The term "miR-378d" refers to the hsa-miR-378d gene (mi RBase Accession No. MIMAT0018926) and other species The hsa-miR-378d gene is a homologue or ortholog of the Be Rezikov E et al., 2006, Genome Res., 16, 1289-12 98. Also, "hsa-miR-378d" can be obtained by the method described in Its precursor, hsa-mir-378d-1, has a hairpin-like structure. mir-378d-2” (miRBase Accession No. MI00167 49, MI0003840, SEQ ID NOs: 513, 514) are known.

[0193] As used herein, "hsa-miR-4701-5p gene" or "hsa-mi The term "miR-4701-5p" refers to hsa-miR-4701 set forth in SEQ ID NO: 116. -5p gene (miRBase Accession No. MIMAT0019798 ) and other species homologs or orthologs. The 01-5p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4701-5p is a precursor of hsa-mir-47, which has a hairpin-like structure. 01" (miRBase Accession No. MI0017334, SEQ ID NO: 5 15) is known.

[0194] As used herein, "hsa-miR-4329 gene" or "hsa-miR-4 The term "miR-4329" refers to the hsa-miR-4329 gene (miR-4329) set forth in SEQ ID NO: 117. RBase Accession No. MIMAT0016923) and other species The hsa-miR-4329 gene is a homologue or ortholog. The method described in ff LA et al., 2009, PLoS One., Vol. 4, e7192 hsa-miR-4329 can be obtained by The miRBase Accession No. 100001266666 (hsa-mir-4329) has an apin-like structure. n No. MI0015901, sequence number 516) is known.

[0195] As used herein, "hsa-miR-185-3p gene" or "hsa-miR The term "miR-185-3p" refers to hsa-miR-185-3p set forth in SEQ ID NO: 118. Gene (miRBase Accession No. MIMAT0004611) and This includes homologs or orthologs of hsa-miR-185-3 in other species. The p gene is from Lagos-Quintana M et al., 2003, RNA., 9, 17 The "hsa-miR-18" can be obtained by the method described in 5-179. 5-3p" has a hairpin-like structure as its precursor "hsa-mir-185" (m iRBase Accession No. MI0000482, sequence number 517) It is being done.

[0196] As used herein, "hsa-miR-552-3p gene" or "hsa-miR The term "miR-552-3p" refers to hsa-miR-552-3p as set forth in SEQ ID NO: 119. Gene (miRBase Accession No. MIMAT0003215) and This includes homologs or orthologs of hsa-miR-552-3 in other species. The p gene is described in Cummins JM et al., 2006, Proc Natl Acad S ci US A., Vol. 103, 3687-3692 In addition, "hsa-miR-552-3p" has a hairpin-like structure as its precursor. The structure of "hsa-mir-552" (miRBase Accession No. I0003557, SEQ ID NO: 518) is known.

[0197] As used herein, "hsa-miR-1273g-5p gene" or "hsa-m The term "miR-1273g-5p" refers to hsa-miR-12 73g-5p gene (miRBase Accession No. MIMAT0020 602) and other species homologs or orthologs. The -1273g-5p gene is described in Reshmi G et al., 2011, Genomics. 97, pp. 333-340. miR-1273g-5p has a hairpin-like structure as its precursor, hsa-mi r-1273g” (miRBase Accession No. MI0018003, SEQ ID NO: 519) is known.

[0198] As used herein, "hsa-miR-6769b-3p gene" or "hsa-m The term "miR-6769b-3p" refers to hsa-miR-6769b-3p as set forth in SEQ ID NO: 121. 69b-3p gene (miRBase Accession No. MIMAT0027 621) and other species homologs or orthologs. The -6769b-3p gene is from Ladewig E et al., 2012, Genome Re s., Vol. 22, pp. 1634-1645. "hsa-miR-6769b-3p" is a precursor of "hsa-miR-6769b-3p" which has a hairpin-like structure. sa-mir-6769b” (miRBase Accession No. MI002 2706, SEQ ID NO: 520) is known.

[0199] As used herein, "hsa-miR-520a-3p gene" or "hsa-mi The term "miR-520a-3p" refers to hsa-miR-520a set forth in SEQ ID NO: 122. -3p gene (miRBase Accession No. MIMAT0002834 ) and other species homologs or orthologs. The 0a-3p gene is described in Bentwich I et al., 2005, Nat Genet., 3 7, pp. 766-770. iR-520a-3p is a precursor of the hairpin-like structure known as hsa-mir- 520a" (miRBase Accession No. MI0003149, sequence no. No. 521) is known.

[0200] As used herein, "hsa-miR-4524b-5p gene" or "hsa-m The term "miR-4524b-5p" refers to hsa-miR-4524b-5p as set forth in SEQ ID NO: 123. 24b-5p gene (miRBase Accession No. MIMAT0022 255) and other species homologs or orthologs. The -4524b-5p gene is described in Tandon M et al., 2012, Oral Dis. 18, pp. 127-131. miR-4524b-5p has a hairpin-like structure as its precursor, hsa-mi r-4524b” (miRBase Accession No. MI0019114, SEQ ID NO: 522) is known.

[0201] As used herein, "hsa-miR-4291 gene" or "hsa-miR-4 The term "miR-4291" refers to the hsa-miR-4291 gene (mi RBase Accession No. MIMAT0016922) and other species The hsa-miR-4291 gene is a Go The method described in ff LA et al., 2009, PLoS One., Vol. 4, e7192 hsa-miR-4291 can be obtained by The miRBase Accession No. hsa-mir-4291 (miRBase Accession No. hsa-mir-4291) has an apin-like structure. n No. MI0015900, sequence number 523) is known.

[0202] As used herein, "hsa-miR-6734-3p gene" or "hsa-mi The term "miR-6734-3p" refers to hsa-miR-6734 set forth in SEQ ID NO: 125. -3p gene (miRBase Accession No. MIMAT0027370 ) and other species homologs or orthologs. The 34-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6734-3p has a hairpin-like structure as its precursor, "hsa-mi r-6734” (miRBase Accession No. MI0022579, Column number 524) is known.

[0203] As used herein, "hsa-miR-143-5p gene" or "hsa-miR The term "miR-143-5p" refers to hsa-miR-143-5p as set forth in SEQ ID NO: 126. Gene (miRBase Accession No. MIMAT0004599) and This includes homologs or orthologs of hsa-miR-143-5 in other species. The p gene is described in Lagos-Quintana M et al., 2002, Curr Biol. 12, pp. 735-739. -miR-143-5p has a hairpin-like structure as its precursor, hsa-mir -143" (miRBase Accession No. MI0000459, sequence no. No. 525) is known.

[0204] As used herein, "hsa-miR-939-3p gene" or "hsa-miR The term "miR-939-3p" refers to hsa-miR-939-3p set forth in SEQ ID NO: 127. Gene (miRBase Accession No. MIMAT0022939) and This includes homologs or orthologs of hsa-miR-939-3 in other species. The p gene is described in Lui WO et al., 2007, Cancer Res., Vol. 67, No. 6031 The miR-93 can be obtained by the method described in US Pat. 9-3p" has a hairpin-like structure as its precursor "hsa-mir-939" (m iRBase Accession No. MI0005761, sequence number 526) It is being done.

[0205] As used herein, "hsa-miR-6889-3p gene" or "hsa-mi The term "miR-6889-3p" refers to hsa-miR-6889 set forth in SEQ ID NO: 128. -3p gene (miRBase Accession No. MIMAT0027679 ) and other species homologs or orthologs. The 89-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6889-3p has a hairpin-like structure as its precursor, "hsa-mi r-6889" (miRBase Accession No. MI0022736, Column number 527) is known.

[0206] As used herein, "hsa-miR-6842-3p gene" or "hsa-mi The term "miR-6842-3p" refers to hsa-miR-6842 as set forth in SEQ ID NO: 129. -3p gene (miRBase Accession No. MIMAT0027587 ) and other species homologs or orthologs. The 42-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6842-3p has a hairpin-like structure as its precursor, "hsa-mi r-6842” (miRBase Accession No. MI0022688, Column number 528) is known.

[0207] As used herein, "hsa-miR-4511 gene" or "hsa-miR-4 The term "miR-4511" refers to the hsa-miR-4511 gene (miR-4511) set forth in SEQ ID NO: 130. RBase Accession No. MIMAT0019048) and other species The hsa-miR-4511 gene is a homologue or ortholog. Ma DD et al., 2010, Blood., Vol. 116, e118-e127 hsa-miR-4511 can be obtained by the method described above. The miRBase Accession No. 10 ... sion No. MI0016877, SEQ ID NO: 529) is known.

[0208] As used herein, "hsa-miR-4318 gene" or "hsa-miR-4 The term "miR-4318" refers to the hsa-miR-4318 gene (miR-4318) set forth in SEQ ID NO: 131. RBase Accession No. MIMAT0016869) and other species The hsa-miR-4318 gene is a homologue or ortholog. The method described in ff LA et al., 2009, PLoS One., Vol. 4, e7192 hsa-miR-4318 can be obtained by The miRBase Accession No. 1001266666, which has an apin-like structure, is a member of the miRBase Accession No. 100126 .... n No. MI0015847, SEQ ID NO: 530) is known.

[0209] As used herein, "hsa-miR-4653-5p gene" or "hsa-mi The term "miR-4653-5p" refers to hsa-miR-4653 as set forth in SEQ ID NO: 132. -5p gene (miRBase Accession No. MIMAT0019718 ) and other species homologs or orthologs. The 53-5p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4653-5p is a precursor of hsa-mir-46, which has a hairpin-like structure. 53" (miRBase Accession No. MI0017281, SEQ ID NO: 5 31) is known.

[0210] As used herein, "hsa-miR-6867-3p gene" or "hsa-mi The term "miR-6867-3p" refers to hsa-miR-6867 set forth in SEQ ID NO: 133. -3p gene (miRBase Accession No. MIMAT0027635 ) and other species homologs or orthologs. The 67-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6867-3p has a hairpin-like structure as its precursor, "hsa-mi r-6867” (miRBase Accession No. MI0022714, Column number 532) is known.

[0211] As used herein, "hsa-miR-133b gene" or "hsa-miR-1 The term "miR-133b" refers to the hsa-miR-133b gene (mi RBase Accession No. MIMAT0000770) and other species The hsa-miR-133b gene is a homologue or ortholog. by the method described in m LP et al., 2003, Science., Vol. 299, 1540 In addition, "hsa-miR-133b" can be obtained by The pin-like structure of "hsa-mir-133b" (miRBase Accession No. No. MI0000822, SEQ ID NO: 533) are known.

[0212] As used herein, "hsa-miR-3196 gene" or "hsa-miR-3 The term "miR-3196" refers to the hsa-miR-3196 gene (miR-3196) set forth in SEQ ID NO: 135. RBase Accession No. MIMAT0015080) and other species The hsa-miR-3196 gene is a homologue or ortholog of the St The method described in ark MS et al., 2010, PLoS One., Vol. 5, e9685 In addition, "hsa-miR-3196" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-3196" (miRBase Accession No. on No. MI0014241, SEQ ID NO: 534) is known.

[0213] As used herein, the term "hsa-miR-193b-3p gene" or "hsa-mi The term "miR-193b-3p" refers to hsa-miR-193b as set forth in SEQ ID NO: 136. -3p gene (miRBase Accession No. MIMAT0002819 ) and other species homologs or orthologs. The 3b-3p genes are described in Bentwich I et al., 2005, Nat Genet., 3 7, pp. 766-770. iR-193b-3p is a precursor of the hairpin-like structure known as hsa-mir- 193b" (miRBase Accession No. MI0003137, sequence no. No. 535) is known.

[0214] As used herein, "hsa-miR-3162-3p gene" or "hsa-mi The term "miR-3162-3p" refers to hsa-miR-3162 as set forth in SEQ ID NO: 137. -3p gene (miRBase Accession No. MIMAT0019213 ) and other species homologs or orthologs. The 62-3p gene is Stark MS et al., 2010, PLoS One., Vol. 5, e The miR-316 can be obtained by the method described in 9685. 2-3p" has a hairpin-like structure as its precursor, "hsa-mir-3162" ( miRBase Accession No. MI0014192, SEQ ID NO: 536) It is known.

[0215] As used herein, "hsa-miR-6819-3p gene" or "hsa-mi The term "miR-6819-3p" refers to hsa-miR-6819 set forth in SEQ ID NO: 138. -3p gene (miRBase Accession No. MIMAT0027539 ) and other species homologs or orthologs. The 19-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6819-3p has a hairpin-like structure as its precursor, "hsa-mi r-6819" (miRBase Accession No. MI0022664, Column number 537) is known.

[0216] As used herein, "hsa-miR-1908-3p gene" or "hsa-mi The term "miR-1908-3p" refers to hsa-miR-1908 as set forth in SEQ ID NO: 139. -3p gene (miRBase Accession No. MIMAT0026916 ) and other species homologs or orthologs. The 08-3p gene is described in Bar M et al., 2008, Stem Cells., Vol. 26, No. 2 The hsa-miR can be obtained by the method described in JP 496-2505. -1908-3p is a precursor of hsa-mir-19, which has a hairpin-like structure. 08" (miRBase Accession No. MI0008329, SEQ ID NO: 5 38) is known.

[0217] As used herein, "hsa-miR-6786-5p gene" or "hsa-mi The term "miR-6786-5p" refers to hsa-miR-6786 set forth in SEQ ID NO: 140. -5p gene (miRBase Accession No. MIMAT0027472 ) and other species homologs or orthologs. The 86-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6786-5p has a hairpin-like structure as its precursor, "hsa-mi r-6786" (miRBase Accession No. MI0022631, Column number 539) is known.

[0218] As used herein, "hsa-miR-3648 gene" or "hsa-miR-3 The term "miR-3648" refers to the hsa-miR-3648 gene (miR-3648) set forth in SEQ ID NO: 141. RBase Accession No. MIMAT0018068) and other species The hsa-miR-3648 gene is a homologue or ortholog of the Me iri E et al., 2010, Nucleic Acids Res., Vol. 38, 6234 The miR-36 can be obtained by the method described in US Pat. No. 6,246,624. 48" has a hairpin-like structure as its precursor, "hsa-mir-3648-1, h sa-mir-3648-2” (miRBase Accession No. MI00 16048, MI0031512, SEQ ID NOs: 540, 541) are known.

[0219] As used herein, "hsa-miR-4513 gene" or "hsa-miR-4 The term "miR-4513" refers to the hsa-miR-4513 gene (miR-4513) set forth in SEQ ID NO: 142. RBase Accession No. MIMAT0019050) and other species The hsa-miR-4513 gene is a homologue or ortholog. Ma DD et al., 2010, Blood., Vol. 116, e118-e127 hsa-miR-4513 can be obtained by the method described above. The miRBase Accession No. 13444444, which forms a hairpin-like structure, is sion No. MI0016879, SEQ ID NO: 542) is known.

[0220] As used herein, "hsa-miR-3652 gene" or "hsa-miR-3 The term "miR-3652" refers to the hsa-miR-3652 gene (miR-3652) set forth in SEQ ID NO: 143. RBase Accession No. MIMAT0018072) and other species The hsa-miR-3652 gene is a homologue or ortholog of the Me iri E et al., 2010, Nucleic Acids Res., Vol. 38, 6234 The miR-36 can be obtained by the method described in US Pat. No. 6,246,624. 52” has a hairpin-like structure as its precursor, “hsa-mir-3652” (mi RBase Accession No. MI0016052, sequence number 543) It is being done.

[0221] As used herein, "hsa-miR-4640-5p gene" or "hsa-mi The term "miR-4640-5p" refers to hsa-miR-4640 as set forth in SEQ ID NO: 144. -5p gene (miRBase Accession No. MIMAT0019699 ) and other species homologs or orthologs. The 40-5p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4640-5p is a precursor of hsa-mir-46, which has a hairpin-like structure. 40" (miRBase Accession No. MI0017267, SEQ ID NO: 4 84) is known.

[0222] As used herein, "hsa-miR-6871-5p gene" or "hsa-mi The term "miR-6871-5p" refers to hsa-miR-6871 set forth in SEQ ID NO: 145. -5p gene (miRBase Accession No. MIMAT0027642 ) and other species homologs or orthologs. The 71-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6871-5p has a hairpin-like structure as its precursor, "hsa-mi r-6871” (miRBase Accession No. MI0022718, Column number 544) is known.

[0223] As used herein, "hsa-miR-7845-5p gene" or "hsa-mi The term "miR-7845-5p" refers to hsa-miR-7845 as set forth in SEQ ID NO: 146. -5p gene (miRBase Accession No. MIMAT0030420 ) and other species homologs or orthologs. The 45-5p gene is Ple H et al., 2012, PLoS One., Vol. 7, e507 46. ​​Also, "hsa-miR-7845- 5p" has a hairpin-like structure as its precursor "hsa-mir-7845" (mi RBase Accession No. MI0025515, sequence number 545) It is being done.

[0224] As used herein, "hsa-miR-3138 gene" or "hsa-miR-3 The term "miR-3138" refers to the hsa-miR-3138 gene (miR-3138) set forth in SEQ ID NO: 147. RBase Accession No. MIMAT0015006) and other species The hsa-miR-3138 gene is a homologue or ortholog of the Cr Eighton CJ et al., 2010, PLoS One., Vol. 5, e9637 hsa-miR-3138 can be obtained by the method described above. The miRBase Accelerator has a hairpin-like structure called "hsa-mir-3138" ( Session No. MI0014161, SEQ ID NO: 546) is known.

[0225] As used herein, "hsa-miR-6884-5p gene" or "hsa-mi The term "miR-6884-5p" refers to hsa-miR-6884 set forth in SEQ ID NO: 148. -5p gene (miRBase Accession No. MIMAT0027668 ) and other species homologs or orthologs. The 84-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6884-5p has a hairpin-like structure as its precursor, "hsa-mi r-6884" (miRBase Accession No. MI0022731, Column number 547) is known.

[0226] As used herein, "hsa-miR-4653-3p gene" or "hsa-mi The term "miR-4653-3p" refers to hsa-miR-4653 as set forth in SEQ ID NO: 149. -3p gene (miRBase Accession No. MIMAT0019719 ) and other species homologs or orthologs. The 53-3p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4653-3p is a precursor of hsa-mir-46, which has a hairpin-like structure. 53" (miRBase Accession No. MI0017281 , SEQ ID NO: 531) is known.

[0227] As used herein, "hsa-miR-636 gene" or "hsa-miR-63 The term "miR-636" refers to the hsa-miR-636 gene (miRBa se Accession No. MIMAT0003306) and other species homologs The hsa-miR-636 gene is a member of the Cumming s JM et al., 2006, Proc Natl Acad Sci U S A., 10 3, pp. 3687-3692. -miR-636 has a hairpin-like structure as its precursor, hsa-mir-63 6" (miRBase Accession No. MI0003651, SEQ ID NO: 54 8) is known.

[0228] As used herein, "hsa-miR-4652-3p gene" or "hsa-mi The term "miR-4652-3p" refers to hsa-miR-4652 as set forth in SEQ ID NO: 151. -3p gene (miRBase Accession No. MIMAT0019717 ) and other species homologs or orthologs. The 52-3p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4652-3p is a precursor of hsa-mir-46, which has a hairpin-like structure. 52" (miRBase Accession No. MI0017280, SEQ ID NO: 5 49) is known.

[0229] As used herein, "hsa-miR-6823-5p gene" or "hsa-mi The term "miR-6823-5p" refers to hsa-miR-6823 as set forth in SEQ ID NO: 152. -5p gene (miRBase Accession No. MIMAT0027546 ) and other species homologs or orthologs. The 23-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6823-5p has a hairpin-like structure as its precursor, "hsa-mi r-6823" (miRBase Accession No. MI0022668, Column number 550) is known.

[0230] As used herein, "hsa-miR-4502 gene" or "hsa-miR-4 The term "miR-4502" refers to the hsa-miR-4502 gene (miR-4502) set forth in SEQ ID NO: 153. RBase Accession No. MIMAT0019038) and other species The hsa-miR-4502 gene is a homologue or ortholog. Ma DD et al., 2010, Blood., Vol. 116, e118-e127 hsa-miR-4502 can be obtained by the method described above. The miRBase Accession No. 100210 ... sion No. MI0016865, SEQ ID NO: 551) is known.

[0231] As used herein, "hsa-miR-7113-5p gene" or "hsa-mi The term "miR-7113-5p" refers to hsa-miR-7113 as set forth in SEQ ID NO: 154. -5p gene (miRBase Accession No. MIMAT0028123 ) and other species homologs or orthologs. The 13-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-7113-5p has a hairpin-like structure as its precursor, "hsa-mi r-7113" (miRBase Accession No. MI0022964, Column number 552) is known.

[0232] As used herein, "hsa-miR-8087 gene" or "hsa-miR-8 The term "miR-8087" refers to the hsa-miR-8087 gene (miR-8087) set forth in SEQ ID NO: 155. RBase Accession No. MIMAT0031014) and other species The hsa-miR-8087 gene is a homologue or ortholog. The method described in ng HJ et al., 2013, Shock., Vol. 39, pp. 480-487 hsa-miR-8087 can be obtained by The apin-like structure of "hsa-mir-8087" (miRBase Accession No. n No. MI0025923, sequence number 553) is known.

[0233] As used herein, "hsa-miR-7154-3p gene" or "hsa-mi The term "miR-7154-3p" refers to hsa-miR-7154 as set forth in SEQ ID NO: 156. -3p gene (miRBase Accession No. MIMAT0028219 ) and other species homologs or orthologs. The 54-3p gene is described in Meunier J et al., 2013, Genome Res., 2 3, pp. 34-45. -7154-3p is a precursor of hsa-mir-71, which has a hairpin-like structure. 54" (miRBase Accession No. MI0023614, SEQ ID NO: 5 54) is known.

[0234] As used herein, "hsa-miR-5189-5p gene" or "hsa-mi The term "miR-5189-5p" refers to hsa-miR-5189 as set forth in SEQ ID NO: 157. -5p gene (miRBase Accession No. MIMAT0021120 ) and other species homologs or orthologs. The 89-5p gene is Schotte D et al., 2011, Leukemia., Vol. 25 , 1389-1399. iR-5189-5p is a precursor of the hairpin-like structure known as hsa-mir- 5189" (miRBase Accession No. MI0018168, sequence no. No. 555) is known.

[0235] As used herein, "hsa-miR-1253 gene" or "hsa-miR-1 The term "miR-1253" refers to the hsa-miR-1253 gene (miR-1253) set forth in SEQ ID NO: 158. RBase Accession No. MIMAT0005904) and other species The hsa-miR-1253 gene is a homologue or ortholog. Rin RD et al., 2008, Genome Res., vol. 18, pp. 610-621 hsa-miR-1253 can be obtained by the method described above. The miRBase Ac receptor has a hairpin-like structure as a precursor protein, hsa-mir-1253 (miRBase Ac Accession No. MI0006387, SEQ ID NO: 556) is known.

[0236] As used herein, "hsa-miR-518c-5p gene" or "hsa-mi The term "miR-518c-5p" refers to hsa-miR-518c set forth in SEQ ID NO: 159. -5p gene (miRBase Accession No. MIMAT0002847 ) and other species homologs or orthologs. The 8c-5p gene is described in Bentwich I et al., 2005, Nat Genet., 3 7, pp. 766-770. iR-518c-5p is a precursor of the hairpin-like structure known as hsa-mir- 518c" (miRBase Accession No. MI0003159, sequence no. No. 557) is known.

[0237] As used herein, "hsa-miR-7151-5p gene" or "hsa-mi The term "miR-7151-5p" refers to hsa-miR-7151 set forth in SEQ ID NO: 160. -5p gene (miRBase Accession No. MIMAT0028212 ) and other species homologs or orthologs. The 51-5p gene is described in Meunier J et al., 2013, Genome Res., 2 3, pp. 34-45. -7151-5p is a precursor of hsa-mir-71, which has a hairpin-like structure. 51" (miRBase Accession No. MI0023611, SEQ ID NO: 5 58) is known.

[0238] As used herein, "hsa-miR-3614-3p gene" or "hsa-mi The term "miR-3614-3p" refers to hsa-miR-3614 set forth in SEQ ID NO: 161. -3p gene (miRBase Accession No. MIMAT0017993 ) and other species homologs or orthologs. The 14-3p gene is described in Witten D et al., 2010, BMC Biol., Vol. 8, No. 5 8. Also, "hsa-miR-3614-3 p” has a hairpin-like structure as its precursor “hsa-mir-3614” (miR Base Accession No. MI0016004, SEQ ID NO: 559) is known are.

[0239] As used herein, "hsa-miR-4727-5p gene" or "hsa-mi The term "miR-4727-5p" refers to hsa-miR-4727 as set forth in SEQ ID NO: 162. -5p gene (miRBase Accession No. MIMAT0019847 ) and other species homologs or orthologs. The 27-5p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4727-5p is a precursor of hsa-mir-47, which has a hairpin-like structure. 27" (miRBase Accession No. MI0017364, SEQ ID NO: 5 60) is known.

[0240] As used herein, "hsa-miR-3682-5p gene" or "hsa-mi The term "miR-3682-5p" refers to hsa-miR-3682 set forth in SEQ ID NO: 163. -5p gene (miRBase Accession No. MIMAT0019222 ) and other species homologs or orthologs. The 82-5p gene is Vaz C et al., 2010, BMC Genomics., Vol. 11 The miR-368 can be obtained by the method described in 2-5p" has a hairpin-like structure as its precursor "hsa-mir-3682" ( miRBase Accession No. MI0016083, SEQ ID NO: 561) It is known.

[0241] As used herein, "hsa-miR-5090 gene" or "hsa-miR-5 The term "miR-5090" refers to the hsa-miR-5090 gene (miR-5090) set forth in SEQ ID NO: 164. RBase Accession No. MIMAT0021082) and other species The hsa-miR-5090 gene is a homologue or ortholog. ng N et al., 2011, J Radiat Res., vol. 52, pp. 425-432 hsa-miR-5090 can be obtained by the method described above. The miRBase Ac receptor has a hairpin-like structure as a precursor protein, "hsa-mir-5090" (miRBase Ac Accession No. MI0017979, SEQ ID NO: 562) is known.

[0242] As used herein, "hsa-miR-337-3p gene" or "hsa-miR The term "miR-337-3p" refers to hsa-miR-337-3p as set forth in SEQ ID NO: 165. Gene (miRBase Accession No. MIMAT0000754) and This includes homologs or orthologs of hsa-miR-337-3 in other species. The p gene is described in Kim J et al., 2004, Proc Natl Acad Sci U S A., Vol. 101, pp. 360-365. "hsa-miR-337-3p" is a precursor of "hs a-mir-337” (miRBase Accession No. MI000080 6, SEQ ID NO: 563) is known.

[0243] As used herein, "hsa-miR-488-5p gene" or "hsa-miR The term "miR-488-5p" refers to hsa-miR-488-5p as set forth in SEQ ID NO: 166. Gene (miRBase Accession No. MIMAT0002804) and This includes homologs or orthologs of hsa-miR-488-5 in other species. The p gene is described in Bentwich I et al., 2005, Nat Genet., vol. 37, no. 7 66-770. 88-5p" has a hairpin-like structure as its precursor "hsa-mir-488" ( miRBase Accession No. MI0003123, SEQ ID NO: 564) It is known.

[0244] As used herein, "hsa-miR-100-5p gene" or "hsa-miR The term "miR-100-5p" refers to hsa-miR-100-5p as set forth in SEQ ID NO: 167. Gene (miRBase Accession No. MIMAT0000098) and This includes homologs or orthologs of hsa-miR-100-5 from other species. The p gene is described in Mourelatos Z et al., 2002, Genes Dev., Vol. 16 The hsa-miR -100-5p is a precursor of hsa-mir-100, which has a hairpin-like structure. ” (miRBase Accession No. MI0000102, SEQ ID NO: 565 ) is known.

[0245] As used herein, "hsa-miR-4520-3p gene" or "hsa-mi The term "miR-4520-3p" refers to hsa-miR-4520-3p as set forth in SEQ ID NO: 168. -3p gene (miRBase Accession No. MIMAT0019057 ) and other species homologs or orthologs. The 20-3p gene is described in Jima DD et al., 2010, Blood., Vol. 116, e11 8-e127. 520-3p has a hairpin-like structure as its precursor, hsa-mir-4520 -1" (miRBase Accession No. MI0016886, SEQ ID NO: 5 66) is known.

[0246] As used herein, "hsa-miR-373-3p gene" or "hsa-miR The term "miR-373-3p" refers to hsa-miR-373-3p set forth in SEQ ID NO: 169. Gene (miRBase Accession No. MIMAT0000726) and This includes homologs or orthologs of hsa-miR-373-3 in other species. The p gene is Suh MR et al., 2004, Dev Biol., vol. 270, pp. 488-4 The miR-373-3 can be obtained by the method described in 98. p” has a hairpin-like structure as its precursor “hsa-mir-373” (miRB p). The enzyme (Accession No. MI0000781, SEQ ID NO: 567) is known There are.

[0247] As used herein, "hsa-miR-6499-5p gene" or "hsa-mi The term "miR-6499-5p" refers to hsa-miR-6499 as set forth in SEQ ID NO: 170. -5p gene (miRBase Accession No. MIMAT0025450 ) and other species homologs or orthologs. The 99-5p gene is Joyce CE et al., 2011, Hum Mol Genet. , vol. 20, pp. 4025-4040. sa-miR-6499-5p has a hairpin-like structure as its precursor, hsa- mir-6499” (miRBase Accession No.MI0022209 , SEQ ID NO: 568) is known.

[0248] As used herein, "hsa-miR-3909 gene" or "hsa-miR-3 The term "miR-3909" refers to the hsa-miR-3909 gene (mi RBase Accession No. MIMAT0018183) and other species The hsa-miR-3909 gene is a homologue or ortholog of the Cr Eighton CJ et al., 2010, PLoS One., Vol. 5, e9637 hsa-miR-3909 can be obtained by the method described above. The miRBase Accelerator has a hairpin-like structure called "hsa-mir-3909" ( Session No. MI0016413, SEQ ID NO: 569) is known.

[0249] As used herein, "hsa-miR-32-5p gene" or "hsa-miR- The term "miR-32-5p" refers to the hsa-miR-32-5p gene set forth in SEQ ID NO: 172. (miRBase Accession No. MIMAT0000090) and other Species homologs or orthologs are included. hsa-miR-32-5p gene Lagos-Quintana M et al., 2001, Science., Vol. 294, The "hsa-miR- 32-5p" has a hairpin-like structure as its precursor, "hsa-mir-32" (m iRBase Accession No. MI0000090, sequence number 570) It is being done.

[0250] As used herein, the term "hsa-miR-302a-3p gene" or "hsa-mi The term "miR-302a-3p" refers to hsa-miR-302a set forth in SEQ ID NO: 173. -3p gene (miRBase Accession No. MIMAT0000684 ) and other species homologs or orthologs. The 2a-3p genes are described in Houbaviy HB et al., 2003, Dev Cell., 5 It can be obtained by the method described in Vol. 351-358. R-302a-3p is a precursor of hsa-mir-3, which has a hairpin-like structure. 02a" (miRBase Accession No. MI0000738, SEQ ID NO: 571) is known.

[0251] As used herein, "hsa-miR-4686 gene" or "hsa-miR-4 The term "miR-4686" refers to the hsa-miR-4686 gene (miR-4686) set forth in SEQ ID NO: 174. RBase Accession No. MIMAT0019773) and other species The hsa-miR-4686 gene is a homologue or ortholog of the rsson H et al., 2011, Cancer Res., 71, 78-86 hsa-miR-4686 can be obtained by the method described above. The miRBase Accelerator has a hairpin-like structure. Session No. MI0017318, SEQ ID NO: 572) is known.

[0252] As used herein, "hsa-miR-4659a-3p gene" or "hsa-m The term "hsa-miR-4659a-3p" refers to hsa-miR-4659a-3p as set forth in SEQ ID NO: 175. 59a-3p gene (miRBase Accession No. MIMAT0019 727) and other species homologs or orthologs. The -4659a-3p gene is described in Persson H et al., 2011, Cancer Re s., Vol. 71, pp. 78-86. -miR-4659a-3p has a hairpin-like structure as its precursor, "hsa-m ir-4659a” (miRBase Accession No. MI0017287 , SEQ ID NO: 573) is known.

[0253] As used herein, "hsa-miR-4287 gene" or "hsa-miR-4 The term "miR-4287" refers to the hsa-miR-4287 gene (miR-4287) set forth in SEQ ID NO: 176. RBase Accession No. MIMAT0016917) and other species The hsa-miR-4287 gene is a homologue of the Go The method described in ff LA et al., 2009, PLoS One., Vol. 4, e7192 hsa-miR-4287 can be obtained by The apin-like structure of "hsa-mir-4287" (miRBase Accession No. 1001001001001) n No. MI0015895, sequence number 574) is known.

[0254] As used herein, "hsa-miR-1301-5p gene" or "hsa-mi The term "miR-1301-5p" refers to hsa-miR-1301 set forth in SEQ ID NO: 177. -5p gene (miRBase Accession No. MIMAT0026639 ) and other species homologs or orthologs. The 01-5p gene is described in Berezikov E et al., 2006, Genome Res. , vol. 16, pp. 1289-1298. sa-miR-1301-5p has a hairpin-like structure as its precursor, hsa- mir-1301” (miRBase Accession No.MI0003815 , SEQ ID NO: 575) is known.

[0255] As used herein, "hsa-miR-593-3p gene" or "hsa-miR The term "miR-593-3p" refers to hsa-miR-593-3p as set forth in SEQ ID NO: 178. Gene (miRBase Accession No. MIMAT0004802) and This includes homologs or orthologs of hsa-miR-593-3 in other species. The p gene is described in Cummins JM et al., 2006, Proc Natl Acad S ci US A., Vol. 103, 3687-3692 In addition, "hsa-miR-593-3p" has a hairpin-like structure as its precursor. The miRBase Accession No. I0003605, SEQ ID NO: 576) is known.

[0256] As used herein, "hsa-miR-517a-3p gene" or "hsa-mi The term "miR-517a-3p" refers to hsa-miR-517a set forth in SEQ ID NO: 179. -3p gene (miRBase Accession No. MIMAT0002852 ) and other species homologs or orthologs. The 7a-3p gene is described in Bentwich I et al., 2005, Nat Genet., 3 7, pp. 766-770. iR-517a-3p is a precursor of the hairpin-like structure known as hsa-mir- 517a" (miRBase Accession No. MI0003161, sequence no. No. 577) is known.

[0257] As used herein, "hsa-miR-517b-3p gene" or "hsa-mi The term "miR-517b-3p" refers to hsa-miR-517b as set forth in SEQ ID NO: 180. -3p gene (miRBase Accession No. MIMAT0002857 ) and other species homologs or orthologs. The 7b-3p gene is described in Bentwich I et al., 2005, Nat Genet., 3 7, pp. 766-770. iR-517b-3p is a precursor of the hairpin-like structure known as hsa-mir- 517b" (miRBase Accession No. MI0003165, sequence no. No. 578) is known.

[0258] As used herein, "hsa-miR-142-3p gene" or "hsa-miR The term "miR-142-3p" refers to hsa-miR-142-3p as set forth in SEQ ID NO: 181. Gene (miRBase Accession No. MIMAT0000434) and This includes homologs or orthologs of hsa-miR-142-3 in other species. The p gene is described in Lagos-Quintana M et al., 2002, Curr Biol. 12, pp. 735-739. -miR-142-3p has a hairpin-like structure as its precursor, hsa-mir -142" (miRBase Accession No. MI0000458, sequence no. No. 579) is known.

[0259] As used herein, "hsa-miR-1185-2-3p gene" or "hsa- The term "miR-1185-2-3p" refers to the hsa-miR- 1185-2-3p gene (miRBase Accession No. MIMAT0 022713) and other species homologs or orthologues. The miR-1185-2-3p gene is described in Berezikov E et al., 2006, Gen It can be obtained by the method described in Ome Res., Vol. 16, 1289-1298. In addition, "hsa-miR-1185-2-3p" has a hairpin-like structure as its precursor. The structure of "hsa-mir-1185-2" (miRBase Accession No. MI0003821, SEQ ID NO: 580) is known.

[0260] As used herein, "hsa-miR-602 gene" or "hsa-miR-60 The term "miR-602" refers to the hsa-miR-602 gene (miRBa se Accession No. MIMAT0003270) and other species homologs The hsa-miR-602 gene is a member of the Cumming s JM et al., 2006, Proc Natl Acad Sci U S A., 10 3, pp. 3687-3692. -miR-602 has a hairpin-like structure as its precursor, hsa-mir-60 2" (miRBase Accession No. MI0003615, SEQ ID NO: 58 1) is known.

[0261] As used herein, "hsa-miR-527 gene" or "hsa-miR-52 The term "miR-527" refers to the hsa-miR-527 gene (miRBa 7) set forth in SEQ ID NO: 184. se Accession No. MIMAT0002862) and other species homologs The hsa-miR-527 gene is a member of the Bentwi ch I et al., 2005, Nat Genet., 37, 766-770 hsa-miR-527 can be obtained by the method described above. The miRBase Accession No. 1000012666666 (hsa-mir-527) forms a hairpin-like structure. on No. MI0003179, SEQ ID NO: 582) is known.

[0262] As used herein, "hsa-miR-518a-5p gene" or "hsa-mi The term "miR-518a-5p" refers to hsa-miR-518a as set forth in SEQ ID NO: 185. -5p gene (miRBase Accession No. MIMAT0005457 ) and other species homologs or orthologs. The 8a-5p gene is described in Bentwich I et al., 2005, Nat Genet., 3 7, pp. 766-770. iR-518a-5p is a precursor of the hairpin-like structure known as hsa-mir- 518a-1, hsa-mir-518a-2” (miRBase Accession No. MI0003170, MI0003173, SEQ ID NO: 583, 584) are known are.

[0263] As used herein, "hsa-miR-4682 gene" or "hsa-miR-4 The term "miR-4682" refers to the hsa-miR-4682 gene (miR-4682) set forth in SEQ ID NO: 186. RBase Accession No. MIMAT0019767) and other species The hsa-miR-4682 gene is a homologue or ortholog of the rsson H et al., 2011, Cancer Res., 71, 78-86 hsa-miR-4682 can be obtained by the method described above. The miRBase Accelerator has a hairpin-like structure. Session No. MI0017314, SEQ ID NO: 585) is known.

[0264] As used herein, "hsa-miR-28-5p gene" or "hsa-miR- The term "miR-28-5p" refers to the hsa-miR-28-5p gene set forth in SEQ ID NO: 187. (miRBase Accession No. MIMAT0000085) and other Species homologs or orthologs are included. hsa-miR-28-5p gene Lagos-Quintana M et al., 2001, Science., Vol. 294, The "hsa-miR- 28-5p" has a hairpin-like structure as its precursor, "hsa-mir-28" (m iRBase Accession No. MI0000086, sequence number 586) It is being done.

[0265] As used herein, "hsa-miR-4252 gene" or "hsa-miR-4 The term "miR-4252" refers to the hsa-miR-4252 gene (miR-4252) set forth in SEQ ID NO: 188. RBase Accession No. MIMAT0016886) and other species The hsa-miR-4252 gene is a homologue or ortholog. The method described in ff LA et al., 2009, PLoS One., Vol. 4, e7192 hsa-miR-4252 can be obtained as a precursor of The miRBase Accession No. 1 (hsa-mir-4252) has an apin-like structure. n No. MI0015864, sequence number 587) is known.

[0266] As used herein, "hsa-miR-452-5p gene" or "hsa-miR The term "miR-452-5p" refers to hsa-miR-452-5p as set forth in SEQ ID NO: 189. Gene (miRBase Accession No. MIMAT0001635) and This includes homologs or orthologs of hsa-miR-452-5 in other species. p gene is Altuvia Y et al., 2005, Nucleic Acids Res ., Vol. 33, pp. 2697-2706. hsa-miR-452-5p is a precursor of hsa- mir-452” (miRBase Accession No. MI0001733, SEQ ID NO: 588) is known.

[0267] As used herein, "hsa-miR-525-5p gene" or "hsa-miR The term "miR-525-5p" refers to hsa-miR-525-5p as set forth in SEQ ID NO: 190. Gene (miRBase Accession No. MIMAT0002838) and This includes homologs or orthologs of hsa-miR-525-5 in other species. The p gene is described in Bentwich I et al., 2005, Nat Genet., vol. 37, no. 7 The miR-5 gene can be obtained by the method described in US Pat. No. 6,667,770. 25-5p" has a hairpin-like structure as its precursor "hsa-mir-525" ( miRBase Accession No. MI0003152, SEQ ID NO: 589) It is known.

[0268] As used herein, "hsa-miR-3622a-3p gene" or "hsa-m The term "hsa-miR-3622a-3p" refers to hsa-miR-3622a-3p as set forth in SEQ ID NO: 191. 22a-3p gene (miRBase Accession No. MIMAT0018 004) and other species homologs or orthologs. The -3622a-3p gene is described in Witten D et al., 2010, BMC Biol. 8, 58. 22a-3p is a precursor of hsa-mir-3622, which has a hairpin-like structure. a" (miRBase Accession No. MI0016013, SEQ ID NO: 59 0) is known.

[0269] As used herein, "hsa-miR-6813-3p gene" or "hsa-mi The term "miR-6813-3p" refers to hsa-miR-6813 as set forth in SEQ ID NO: 192. -3p gene (miRBase Accession No. MIMAT0027527 ) and other species homologs or orthologs. The 13-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6813-3p has a hairpin-like structure as its precursor, "hsa-mi r-6813" (miRBase Accession No. MI0022658, Column number 591) is known.

[0270] As used herein, "hsa-miR-4769-3p gene" or "hsa-mi The term "miR-4769-3p" refers to hsa-miR-4769 as set forth in SEQ ID NO: 193. -3p gene (miRBase Accession No. MIMAT0019923 ) and other species homologs or orthologs. The 69-3p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4769-3p is a precursor of hsa-mir-47, which has a hairpin-like structure. 69" (miRBase Accession No. MI0017410, SEQ ID NO: 5 92) is known.

[0271] As used herein, "hsa-miR-5698 gene" or "hsa-miR-5 The term "miR-5698" refers to the hsa-miR-5698 gene (miR-5698) set forth in SEQ ID NO: 194. RBase Accession No. MIMAT0022491) and other species The hsa-miR-5698 gene is a homologue or ortholog of the Wa Tahiki A et al., 2011, PLoS One., Vol. 6, e24950 Furthermore, "hsa-miR-5698" can be obtained by the method described above. The miRBase Accession No. 100002666666686 has a hairpin-like structure as a target gene. The sequence number of the gene encoding the nucleotide sequence of the present invention is 593 (sequence number MI0019305, sequence number 593).

[0272] As used herein, "hsa-miR-1915-3p gene" or "hsa-mi The term "miR-1915-3p" refers to hsa-miR-1915 as set forth in SEQ ID NO: 195. -3p gene (miRBase Accession No. MIMAT0007892 ) and other species homologs or orthologs. The 15-3p gene is Bar M et al., 2008, Stem Cells., Vol. 26, No. 2 The hsa-miR can be obtained by the method described in JP 496-2505. -1915-3p is a precursor of hsa-mir-19, which has a hairpin-like structure. 15" (miRBase Accession No. MI0008336, SEQ ID NO: 5 94) is known.

[0273] As used herein, "hsa-miR-1343-5p gene" or "hsa-mi The term "miR-1343-5p" refers to hsa-miR-1343 as set forth in SEQ ID NO: 196. -5p gene (miRBase Accession No. MIMAT0027038 ) and other species homologs or orthologs. The 43-5p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -1343-5p is a precursor of hsa-mir-13, which has a hairpin-like structure. 43" (miRBase Accession No. MI0017320, SEQ ID NO: 5 95) is known.

[0274] As used herein, "hsa-miR-6861-5p gene" or "hsa-mi The term "miR-6861-5p" refers to hsa-miR-6861 set forth in SEQ ID NO: 197. -5p gene (miRBase Accession No. MIMAT0027623 ) and other species homologs or orthologs. The 61-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6861-5p has a hairpin-like structure as its precursor, "hsa-mi r-6861” (miRBase Accession No. MI0022708, Column number 596) is known.

[0275] As used herein, "hsa-miR-6781-5p gene" or "hsa-mi The term "miR-6781-5p" refers to hsa-miR-6781 set forth in SEQ ID NO: 198. -5p gene (miRBase Accession No. MIMAT0027462 ) and other species homologs or orthologs. The 81-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6781-5p has a hairpin-like structure as its precursor, "hsa-mi r-6781" (miRBase Accession No. MI0022626, Column number 597) is known.

[0276] As used herein, "hsa-miR-4508 gene" or "hsa-miR-4 The term "miR-4508" refers to the hsa-miR-4508 gene (miR-4508) set forth in SEQ ID NO: 199. RBase Accession No. MIMAT0019045) and other species The hsa-miR-4508 gene is a homologue or ortholog. Ma DD et al., 2010, Blood., Vol. 116, e118-e127 Furthermore, "hsa-miR-4508" can be obtained by the method described above. The miRBase Accession No. 1006266666, which forms a hairpin-like structure, is sion No. MI0016872, SEQ ID NO: 598) is known.

[0277] As used herein, "hsa-miR-6743-5p gene" or "hsa-mi The term "miR-6743-5p" refers to hsa-miR-6743 as set forth in SEQ ID NO: 200. -5p gene (miRBase Accession No. MIMAT0027387 ) and other species homologs or orthologs. The 43-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6743-5p has a hairpin-like structure as its precursor, "hsa-mi r-6743" (miRBase Accession No. MI0022588, Column number 599) is known.

[0278] As used herein, "hsa-miR-6726-5p gene" or "hsa-mi The term "miR-6726-5p" refers to hsa-miR-6726 set forth in SEQ ID NO: 201. -5p gene (miRBase Accession No. MIMAT0027353 ) and other species homologs or orthologs. The 26-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6726-5p has a hairpin-like structure as its precursor, "hsa-mi r-6726" (miRBase Accession No. MI0022571, Column number 600) is known.

[0279] As used herein, "hsa-miR-4525 gene" or "hsa-miR-4 The term "miR-4525" refers to the hsa-miR-4525 gene (miR-4525) set forth in SEQ ID NO: 202. RBase Accession No. MIMAT0019064) and other species The hsa-miR-4525 gene is a homologue or ortholog. Ma DD et al., 2010, Blood., Vol. 116, e118-e127 hsa-miR-4525 can be obtained by the method described above. The miRBase Accession No. 100001266666, which has a hairpin-like structure, is a missense mutation called "hsa-mir-4525" (miRBase Accession No. 100001266666666). sion No. MI0016892, SEQ ID NO: 601) is known.

[0280] As used herein, "hsa-miR-4651 gene" or "hsa-miR-4 The term "miR-4651" refers to the hsa-miR-4651 gene (miR-4651) set forth in SEQ ID NO: 203. RBase Accession No. MIMAT0019715) and other species The hsa-miR-4651 gene is a homologue or ortholog of the rsson H et al., 2011, Cancer Res., 71, 78-86 hsa-miR-4651 can be obtained by the method described above. The miRBase Accelerator has a hairpin-like structure. Session No. MI0017279, SEQ ID NO: 602) is known.

[0281] As used herein, "hsa-miR-6813-5p gene" or "hsa-mi The term "miR-6813-5p" refers to hsa-miR-6813 as set forth in SEQ ID NO: 204. -5p gene (miRBase Accession No. MIMAT0027526 ) and other species homologs or orthologs. The 13-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6813-5p has a hairpin-like structure as its precursor, "hsa-mi r-6813” (miRBase Accession No. MI0022658, SEQ ID NO: 591) is known.

[0282] As used herein, "hsa-miR-5787 gene" or "hsa-miR-5 The term "miR-5787" refers to the hsa-miR-5787 gene (miR-5787) set forth in SEQ ID NO: 205. RBase Accession No. MIMAT0023252) and other species The hsa-miR-5787 gene is a homologue or ortholog. o H et al., 2011, Biochem Biophys Res Commun., 4 15, pp. 567-572. miR-5787 has a hairpin-like structure as its precursor, hsa-mir-57 87" (miRBase Accession No. MI0019797, SEQ ID NO: 6 03) is known.

[0283] As used herein, "hsa-miR-1290 gene" or "hsa-miR-1 The term "miR-1290" refers to the hsa-miR-1290 gene (miR-1290) set forth in SEQ ID NO: 206. RBase Accession No. MIMAT0005880) and other species The hsa-miR-1290 gene is a homologue or ortholog. Rin RD et al., 2008, Genome Res., vol. 18, pp. 610-621 hsa-miR-1290 can be obtained by the method described above. The miRBase Ac receptor has a hairpin-like structure as a carrier protein, Accession No. MI0006352, SEQ ID NO: 604) is known.

[0284] As used herein, "hsa-miR-6075 gene" or "hsa-miR-6 The term "miR-6075" refers to the hsa-miR-6075 gene (miR-6075) set forth in SEQ ID NO: 207. RBase Accession No. MIMAT0023700) and other species The hsa-miR-6075 gene is a homologue or ortholog of the Vo As described in ellenkle C et al., 2012, RNA., vol. 18, 472-484 hsa-miR-6075 can be obtained by the method described above. The miRBase Accession No. 100002666666, which has a hairpin-like structure, is sion No. MI0020352, SEQ ID NO: 605) is known.

[0285] As used herein, "hsa-miR-4758-5p gene" or "hsa-mi The term "miR-4758-5p" refers to hsa-miR-4758 as set forth in SEQ ID NO: 208. -5p gene (miRBase Accession No. MIMAT0019903 ) and other species homologs or orthologs. The 58-5p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4758-5p is a precursor of hsa-mir-47, which has a hairpin-like structure. 58" (miRBase Accession No. MI0017399, SEQ ID NO: 6 06) is known.

[0286] As used herein, "hsa-miR-4690-5p gene" or "hsa-mi The term "miR-4690-5p" refers to hsa-miR-4690 set forth in SEQ ID NO: 209. -5p gene (miRBase Accession No. MIMAT0019779 ) and other species homologs or orthologs. The 90-5p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4690-5p is a precursor of hsa-mir-46, which has a hairpin-like structure. 90" (miRBase Accession No. MI0017323, SEQ ID NO: 6 07) is known.

[0287] As used herein, "hsa-miR-762 gene" or "hsa-miR-76 The term "miR-762" refers to the hsa-miR-762 gene (miRBa se Accession No. MIMAT0010313) and other species homologs The hsa-miR-762 gene is a member of the Berezi kov E et al., 2006, Genome Res., 16, 1289-1298 hsa-miR-762 can be obtained by the method described in the literature. The miRBase Accelerator, "hsa-mir-762" (miRBase Accelerator), has a hairpin-like structure. Session No. MI0003892, SEQ ID NO: 608) is known.

[0288] As used herein, "hsa-miR-1225-3p gene" or "hsa-mi The term "miR-1225-3p" refers to hsa-miR-1225 as set forth in SEQ ID NO: 211. -3p gene (miRBase Accession No. MIMAT0005573 ) and other species homologs or orthologs. The 25-3p gene is described in Berezikov E et al., 2007, Mol Cell., 2 8, pp. 328-336. iR-1225-3p is a precursor of the hairpin-like structure known as hsa-mir- 1225" (miRBase Accession No. MI0006311, sequence no. No. 609) is known.

[0289] As used herein, "hsa-miR-3184-5p gene" or "hsa-mi The term "miR-3184-5p" refers to hsa-miR-3184 set forth in SEQ ID NO: 212. -5p gene (miRBase Accession No. MIMAT0015064 ) and other species homologs or orthologs. The 84-5p gene is described in Stark MS et al., 2010, PLoS One., Vol. 5, e The miR-318 can be obtained by the method described in 9685. 4-5p" has a hairpin-like structure as its precursor "hsa-mir-3184" ( miRBase Accession No. MI0014226, SEQ ID NO: 398) It is known.

[0290] As used herein, "hsa-miR-665 gene" or "hsa-miR-66 The term "miR-665" refers to the hsa-miR-665 gene (miRBa se Accession No. MIMAT0004952) and other species homologs The hsa-miR-665 gene is a member of the Berezi kov E et al., 2006, Genome Res., 16, 1289-1298 hsa-miR-665 can be obtained by the method described in the literature. The miRBase Accelerator, "hsa-mir-665" (miRBase Accelerator), has a hairpin-like structure. Session No. MI0005563, SEQ ID NO: 610) is known.

[0291] As used herein, "hsa-miR-211-5p gene" or "hsa-miR The term "miR-211-5p" refers to hsa-miR-211-5p set forth in SEQ ID NO: 214. Gene (miRBase Accession No. MIMAT0000268) and This includes homologs or orthologs of hsa-miR-211-5 in other species. The p gene is described in Lim LP et al., 2003, Science., Vol. 299, 1540. Furthermore, "hsa-miR-211-5p" can be obtained by the method described in Its precursor, "hsa-mir-211" (miRBase Accession No. MI0000287, SEQ ID NO: 611) is known.

[0292] As used herein, "hsa-miR-1247-5p gene" or "hsa-mi The term "miR-1247-5p" refers to hsa-miR-1247 as set forth in SEQ ID NO: 215. -5p gene (miRBase Accession No. MIMAT0005899 ) and other species homologs or orthologs. The 47-5p gene is Morin RD et al., 2008, Genome Res., 18 It can be obtained by the method described in Vol. 610-621. R-1247-5p is a precursor of hsa-mir-1, which has a hairpin-like structure. 247" (miRBase Accession No. MI0006382, SEQ ID NO: 489) is known.

[0293] As used herein, "hsa-miR-3656 gene" or "hsa-miR-3 The term "miR-3656" refers to the hsa-miR-3656 gene (miR-3656) set forth in SEQ ID NO: 216. RBase Accession No. MIMAT0018076) and other species The hsa-miR-3656 gene is a homologue or ortholog of the Me iri E et al., 2010, Nucleic Acids Res., Vol. 38, 6234 The miR-36 can be obtained by the method described in US Pat. No. 6,246,624. 56" has a hairpin-like structure as its precursor, "hsa-mir-3656" (mi RBase Accession No. MI0016056, sequence number 612) is known. It is being done.

[0294] As used herein, "hsa-miR-149-5p gene" or "hsa-miR The term "miR-149-5p" refers to hsa-miR-149-5p as set forth in SEQ ID NO: 217. Gene (miRBase Accession No. MIMAT0000450) and This includes homologs or orthologs of hsa-miR-149-5 in other species. The p gene is described in Lagos-Quintana M et al., 2002, Curr Biol. 12, pp. 735-739. -miR-149-5p has a hairpin-like structure as its precursor, hsa-mir -149" (miRBase Accession No. MI0000478, sequence no. No. 613) is known.

[0295] As used herein, "hsa-miR-744-5p gene" or "hsa-miR The term "miR-744-5p" refers to hsa-miR-744-5p set forth in SEQ ID NO: 218. Gene (miRBase Accession No. MIMAT0004945) and This includes homologs or orthologs of hsa-miR-744-5 in other species. The p gene is from Berezikov E et al., 2006, Genome Res., Vol. 16 , 1289-1298. iR-744-5p is a precursor of hsa-mir-7, which has a hairpin-like structure. 44" (miRBase Accession No. MI0005559, SEQ ID NO: 6 14) is known.

[0296] As used herein, "hsa-miR-345-5p gene" or "hsa-miR The term "miR-345-5p" refers to hsa-miR-345-5p set forth in SEQ ID NO: 219. Gene (miRBase Accession No. MIMAT0000772) and This includes homologs or orthologs of hsa-miR-345-5 in other species. The p gene is described in Kim J et al., 2004, Proc Natl Acad Sci U S A., Vol. 101, pp. 360-365. "hsa-miR-345-5p" is a precursor of "hs a-mir-345” (miRBase Accession No. MI000082 5, SEQ ID NO: 615) is known.

[0297] As used herein, "hsa-miR-150-5p gene" or "hsa-miR The term "miR-150-5p" refers to hsa-miR-150-5p as set forth in SEQ ID NO: 220. Gene (miRBase Accession No. MIMAT0000451) and This includes homologs or orthologs of hsa-miR-150-5 in other species. The p gene is described in Lagos-Quintana M et al., 2002, Curr Biol. 12, pp. 735-739. -miR-150-5p has a hairpin-like structure as its precursor, hsa-mir -150" (miRBase Accession No. MI0000479, sequence no. No. 616) is known.

[0298] As used herein, "hsa-miR-191-3p gene" or "hsa-miR The term "miR-191-3p" refers to hsa-miR-191-3p set forth in SEQ ID NO: 221. Gene (miRBase Accession No. MIMAT0001618) and This includes homologs or orthologs of hsa-miR-191-3 in other species. The p gene is from Lagos-Quintana M et al., 2003, RNA., 9, 17 The "hsa-miR-19" can be obtained by the method described in 5-179. 1-3p" has a hairpin-like structure as its precursor "hsa-mir-191" (m iRBase Accession No. MI0000465, sequence number 617) It is being done.

[0299] As used herein, "hsa-miR-651-5p gene" or "hsa-miR The term "miR-651-5p" refers to hsa-miR-651-5p set forth in SEQ ID NO: 222. Gene (miRBase Accession No. MIMAT0003321) and This includes homologs or orthologs of hsa-miR-651-5 in other species. The p gene is described in Cummins JM et al., 2006, Proc Natl Acad S ci US A., Vol. 103, 3687-3692 In addition, "hsa-miR-651-5p" has a hairpin-like structure as its precursor. The miRBase Accession No. I0003666, SEQ ID NO: 618) is known.

[0300] As used herein, "hsa-miR-34a-5p gene" or "hsa-miR The term "miR-34a-5p" refers to hsa-miR-34a-5p as set forth in SEQ ID NO: 223. Gene (miRBase Accession No. MIMAT0000255) and This includes homologs or orthologs of hsa-miR-34a-5 from other species. The p gene is described in Dostie J et al., 2003, RNA., Vol. 9, 180-186. Furthermore, "hsa-miR-34a-5p" can be obtained by the method described above. The precursor of miR, hsa-mir-34a (miRBase A Accession No. MI0000268, SEQ ID NO: 619) is known.

[0301] As used herein, "hsa-miR-409-5p gene" or "hsa-miR The term "miR-409-5p" refers to hsa-miR-409-5p as set forth in SEQ ID NO: 224. Gene (miRBase Accession No. MIMAT0001638) and This includes homologs or orthologs of hsa-miR-409-5 in other species. p gene is Altuvia Y et al., 2005, Nucleic Acids Res ., Vol. 33, pp. 2697-2706. hsa-miR-409-5p is a precursor of hsa- mir-409” (miRBase Accession No. MI0001735, SEQ ID NO: 620) is known.

[0302] As used herein, "hsa-miR-369-5p gene" or "hsa-miR The term "miR-369-5p" refers to hsa-miR-369-5p set forth in SEQ ID NO: 225. Gene (miRBase Accession No. MIMAT0001621) and This includes homologs or orthologs of hsa-miR-369-5 in other species. The p gene is Suh MR et al., 2004, Dev Biol., vol. 270, pp. 488-4 The miR-369-5 gene can be obtained by the method described in 98. p” has a hairpin-like structure as its precursor “hsa-mir-369” (miRB p). The enzyme is known to have the following structure: There are.

[0303] As used herein, "hsa-miR-1915-5p gene" or "hsa-mi The term "miR-1915-5p" refers to hsa-miR-1915 as set forth in SEQ ID NO: 226. -5p gene (miRBase Accession No. MIMAT0007891 ) and other species homologs or orthologs. The 15-5p gene is described in Bar M et al., 2008, Stem Cells., Vol. 26, No. 2 The hsa-miR can be obtained by the method described in JP 496-2505. -1915-5p is a precursor of hsa-mir-19, which has a hairpin-like structure. 15" (miRBase Accession No. MI0008336, SEQ ID NO: 5 94) is known.

[0304] As used herein, "hsa-miR-204-5p gene" or "hsa-miR The term "miR-204-5p" refers to hsa-miR-204-5p as set forth in SEQ ID NO: 227. Gene (miRBase Accession No. MIMAT0000265) and This includes homologs or orthologs of hsa-miR-204-5 in other species. The p gene is described in Lim LP et al., 2003, Science., Vol. 299, 1540. Furthermore, "hsa-miR-204-5p" can be obtained by the method described in Its precursor, "hsa-mir-204" (miRBase Accession No. MI0000284, SEQ ID NO: 622) is known.

[0305] As used herein, "hsa-miR-137 gene" or "hsa-miR-13 The term "miR-137" refers to the hsa-miR-137 gene (miRBa se Accession No. MIMAT0000429) and other species homologs The hsa-miR-137 gene is a member of the Lagos- Quintana M et al., 2002, Curr Biol., 12, 735-739 Furthermore, "hsa-miR-137" can be obtained by the method described in The precursor of the hairpin-like structure "hsa-mir-137" (miRBase A Accession No. MI0000454, SEQ ID NO: 623) is known.

[0306] As used herein, "hsa-miR-382-5p gene" or "hsa-miR The term "miR-382-5p" refers to hsa-miR-382-5p set forth in SEQ ID NO: 229. Gene (miRBase Accession No. MIMAT0000737) and This includes homologs or orthologs of hsa-miR-382-5 in other species. p gene is Altuvia Y et al., 2005, Nucleic Acids Res ., Vol. 33, pp. 2697-2706. hsa-miR-382-5p is a precursor of hsa- mir-382” (miRBase Accession No. MI0000790, SEQ ID NO: 624) is known.

[0307] As used herein, "hsa-miR-517-5p gene" or "hsa-miR The term "miR-517-5p" refers to hsa-miR-517-5p as set forth in SEQ ID NO: 230. Gene (miRBase Accession No. MIMAT0002851) and This includes homologs or orthologs of hsa-miR-517-5 in other species. The p gene is described in Bentwich I et al., 2005, Nat Genet., vol. 37, no. 7 The miR-5 gene can be obtained by the method described in US Pat. No. 6,667,770. "17-5p" has a hairpin-like structure as its precursor, "hsa-mir-517c" (miRBase Accession No. MI0003174, SEQ ID NO: 625) is known.

[0308] As used herein, "hsa-miR-532-5p gene" or "hsa-miR The term "miR-532-5p" refers to hsa-miR-532-5p set forth in SEQ ID NO: 231. Gene (miRBase Accession No. MIMAT0002888) and This includes homologs or orthologs of hsa-miR-532-5 in other species. The p gene is described in Lagos-Quintana M et al., 2001, Science., 2 94, pp. 853-858. miR-532-5p has a hairpin-like structure as its precursor, hsa-mir- 532" (miRBase Accession No. MI0003205, SEQ ID NO: 626) is known.

[0309] As used herein, "hsa-miR-22-5p gene" or "hsa-miR- The term "miR-22-5p" refers to the hsa-miR-22-5p gene set forth in SEQ ID NO: 232. (miRBase Accession No. MIMAT0004495) and other Species homologs or orthologs are included. hsa-miR-22-5p gene Berezikov E et al., 2007, Mol Cell., 28, 328-3 36. " has a hairpin-like structure as its precursor, "hsa-mir-22" (miRBas e Accession No. MI0000078, SEQ ID NO: 627) is known .

[0310] As used herein, "hsa-miR-1237-3p gene" or "hsa-mi The term "miR-1237-3p" refers to hsa-miR-1237 as set forth in SEQ ID NO: 233. -3p gene (miRBase Accession No. MIMAT0005592 ) and other species homologs or orthologs. The 37-3p gene is described in Berezikov E et al., 2006, Genome Res. , vol. 16, pp. 1289-1298. sa-miR-1237-3p has a hairpin-like structure as its precursor, hsa- mir-1237” (miRBase Accession No. MI0006327 , SEQ ID NO: 628) is known.

[0311] As used herein, "hsa-miR-1224-3p gene" or "hsa-mi The term "miR-1224-3p" refers to hsa-miR-1224 set forth in SEQ ID NO: 234. -3p gene (miRBase Accession No. MIMAT0005459 ) and other species homologs or orthologs. The 24-3p gene is described in Cummins JM et al., 2006, Proc Natl Ac Ad Sci U S A., Vol. 103, 3687-3692 Furthermore, "hsa-miR-1224-3p" can be obtained as a precursor of hsa-miR-1224-3p. The apin-like structure of "hsa-mir-1224" (miRBase Accession No. 1224) n No. MI0003764, sequence number 629) is known.

[0312] As used herein, "hsa-miR-625-3p gene" or "hsa-miR The term "miR-625-3p" refers to hsa-miR-625-3p set forth in SEQ ID NO: 235. Gene (miRBase Accession No. MIMAT0004808) and This includes homologs or orthologs of hsa-miR-625-3 in other species. The p gene is described in Kim J et al., 2004, Proc Natl Acad Sci U S A., Vol. 101, pp. 360-365. "hsa-miR-625-3p" is a precursor of "hs a-mir-625” (miRBase Accession No. MI000363 9, SEQ ID NO: 630) is known.

[0313] As used herein, "hsa-miR-328-3p gene" or "hsa-miR The term "miR-328-3p" refers to hsa-miR-328-3p set forth in SEQ ID NO: 236. Gene (miRBase Accession No. MIMAT0000752) and This includes homologs or orthologs of hsa-miR-328-3 in other species. The p gene is described in Lagos-Quintana M et al., 2002, Curr Biol. 12, pp. 735-739. -miR-328-3p has a hairpin-like structure as its precursor, hsa-mir -328" (miRBase Accession No. MI0000804, sequence no. No. 631) is known.

[0314] As used herein, "hsa-miR-122-5p gene" or "hsa-miR The term "miR-122-5p" refers to hsa-miR-122-5p as set forth in SEQ ID NO: 237. Gene (miRBase Accession No. MIMAT0000421) and This includes homologs or orthologs of hsa-miR-122-5 in other species. The p gene is described in Bentwich I et al., 2005, Nat Genet., vol. 37, no. 7 66-770. 22-5p" has a hairpin-like structure as its precursor "hsa-mir-122" ( miRBase Accession No. MI0000442, SEQ ID NO: 632) It is known.

[0315] As used herein, "hsa-miR-202-3p gene" or "hsa-miR The term "miR-202-3p" refers to hsa-miR-202-3p set forth in SEQ ID NO: 238. Gene (miRBase Accession No. MIMAT0002811) and This includes homologs or orthologs of hsa-miR-202-3 in other species. The p gene is described in Persson H et al., 2011, Cancer Res., Vol. 71, No. 7 8-86. The precursor of α-3p is hsa-mir-202 (mi RBase Accession No. MI0003130, sequence number 485) It is being done.

[0316] As used herein, "hsa-miR-4781-5p gene" or "hsa-mi The term "miR-4781-5p" refers to hsa-miR-4781 set forth in SEQ ID NO: 239. -5p gene (miRBase Accession No. MIMAT0019942 ) and other species homologs or orthologs. The 81-5p gene is from Artzi S et al., 2008, BMC Bioinformatics ICS, Vol. 9, p. 39. iR-4781-5p is a precursor of the hairpin-like structure known as hsa-mir- 4781" (miRBase Accession No. MI0017426, sequence no. No. 633) is known.

[0317] As used herein, "hsa-miR-718 gene" or "hsa-miR-71 The term "miR-718" refers to the hsa-miR-718 gene (miRBa se Accession No. MIMAT0012735) and other species homologs The hsa-miR-718 gene is described in Kim J et al. ,2004,Proc Natl Acad Sci U S A.,Vol.101,36 0-365. 8” has a hairpin-like structure as its precursor, “hsa-mir-718” (miRB The enzyme (Accession No. MI0012489, SEQ ID NO: 634) is known There are.

[0318] As used herein, "hsa-miR-342-3p gene" or "hsa-miR The term "miR-342-3p" refers to hsa-miR-342-3p set forth in SEQ ID NO: 241. Gene (miRBase Accession No. MIMAT0000753) and This includes homologs or orthologs of hsa-miR-342-3 in other species. The p gene is described in Lagos-Quintana M et al., 2001, Science., 2 94, pp. 853-858. miR-342-3p has a hairpin-like structure as its precursor, hsa-mir- 342" (miRBase Accession No. MI0000805, SEQ ID NO: 635) is known.

[0319] As used herein, "hsa-miR-26b-3p gene" or "hsa-miR The term "miR-26b-3p" refers to hsa-miR-26b-3p as set forth in SEQ ID NO: 242. Gene (miRBase Accession No. MIMAT0004500) and This includes homologs or orthologs of hsa-miR-26b-3 in other species. The p gene is described in Lagos-Quintana M et al., 2002, Curr Biol. 12, pp. 735-739. -miR-26b-3p has a hairpin-like structure as its precursor, hsa-mir -26b" (miRBase Accession No. MI0000084, sequence no. No. 636) is known.

[0320] As used herein, "hsa-miR-140-3p gene" or "hsa-miR The term "miR-140-3p" refers to hsa-miR-140-3p as set forth in SEQ ID NO: 243. Gene (miRBase Accession No. MIMAT0004597) and This includes homologs or orthologs of hsa-miR-140-3 in other species. The p gene is from Lagos-Quintana M et al., 2003, RNA., 9, 17 The miR-14 gene can be obtained by the method described in 5-179. 0-3p" has a hairpin-like structure as its precursor "hsa-mir-140" (m iRBase Accession No. MI0000456, sequence number 637) It is being done.

[0321] As used herein, "hsa-miR-200a-3p gene" or "hsa-mi The term "miR-200a-3p" refers to hsa-miR-200a set forth in SEQ ID NO: 244. -3p gene (miRBase Accession No. MIMAT0000682 ) and other species homologs or orthologs. The 0a-3p gene is described in Kasashima K et al., 2004, Biochem Bio Phys Res Commun., Vol. 322, 403-410. Furthermore, "hsa-miR-200a-3p" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-200a" (miRBase Accession No. on No. MI0000737, SEQ ID NO: 638) is known.

[0322] As used herein, the term "hsa-miR-378a-3p gene" or "hsa-mi The term "miR-378a-3p" refers to hsa-miR-378a set forth in SEQ ID NO: 245. -3p gene (miRBase Accession No. MIMAT0000732 ) and other species homologs or orthologs. The 8a-3p gene is described in Fu H et al., 2005, FEBS Lett., Vol. 579, No. 38 The "hsa-miR- 378a-3p is a precursor of hsa-mir-378, which has a hairpin-like structure. a" (miRBase Accession No. MI0000786, SEQ ID NO: 63 9) is known.

[0323] As used herein, "hsa-miR-484 gene" or "hsa-miR-48 The term "miR-484" refers to the hsa-miR-484 gene (miRBa se Accession No. MIMAT0002174) and other species homologs The hsa-miR-484 gene is a member of the Houbav The method described in iy HB et al., 2003, Dev Cell., Vol. 5, 351-358 hsa-miR-484 can be obtained by the method described above. The hairpin-like structure of "hsa-mir-484" (miRBase Accession No. n No. MI0002468, SEQ ID NO: 640) is known.

[0324] As used herein, "hsa-miR-296-5p gene" or "hsa-miR The term "miR-296-5p" refers to hsa-miR-296-5p set forth in SEQ ID NO: 247. Gene (miRBase Accession No. MIMAT0000690) and This includes homologs or orthologs of hsa-miR-296-5 in other species. The p gene is described in Lim LP et al., 2003, Science., Vol. 299, 1540. hsa-miR-296-5p can be obtained by the method described in Its precursor, hsa-mir-296 (miRBase Accession No. MI0000747, SEQ ID NO: 641) is known.

[0325] As used herein, "hsa-miR-205-5p gene" or "hsa-miR The term "miR-205-5p" refers to hsa-miR-205-5p set forth in SEQ ID NO: 248. Gene (miRBase Accession No. MIMAT0000266) and This includes homologs or orthologs of hsa-miR-205-5 in other species. p gene is Altuvia Y et al., 2005, Nucleic Acids Res ., Vol. 33, pp. 2697-2706. hsa-miR-205-5p is a precursor of hsa- mir-205” (miRBase Accession No. MI0000285, SEQ ID NO: 642) is known.

[0326] As used herein, "hsa-miR-431-5p gene" or "hsa-miR The term "miR-431-5p" refers to hsa-miR-431-5p set forth in SEQ ID NO: 249. Gene (miRBase Accession No. MIMAT0001625) and This includes homologs or orthologs of hsa-miR-431-5 in other species. The p gene is Kawaji H et al., 2008, BMC Genomics., Vol. 9, No. 1 57. Also, "hsa-miR-431-5" can be obtained by the method described in p” has a hairpin-like structure as its precursor, “hsa-mir-431” (miRB p). The enzyme (Accession No. MI0001721, SEQ ID NO: 643) is known There are.

[0327] As used herein, "hsa-miR-1471 gene" or "hsa-miR-1 The term "miR-1471" refers to the hsa-miR-1471 gene (miR-1471) set forth in SEQ ID NO: 250. RBase Accession No. MIMAT0007349) and other species The hsa-miR-1471 gene is a homologue or ortholog. uma-Mukai A et al., 2008, Proc Natl Acad Sci U S A., vol. 105, pp. 7964-7969. In addition, "hsa-miR-1471" has a hairpin-like structure as its precursor, "hs a-mir-1471” (miRBase Accession No. MI00070 76, SEQ ID NO: 644) is known.

[0328] As used herein, "hsa-miR-1538 gene" or "hsa-miR-1 The term "miR-1538" refers to the hsa-miR-1538 gene (miR-1538) set forth in SEQ ID NO: 251. RBase Accession No. MIMAT0007400) and other species The hsa-miR-1538 gene is a homologue or ortholog of the Cu mmins JM et al., 2006, Proc Natl Acad Sci USA ., Vol. 103, pp. 3687-3692. "hsa-miR-1538" is a precursor of "hsa-m ir-1538” (miRBase Accession No. MI0007259, SEQ ID NO: 645) is known.

[0329] As used herein, the term "hsa-miR-449b-3p gene" or "hsa-mi The term "miR-449b-3p" refers to hsa-miR-449b set forth in SEQ ID NO: 252. -3p gene (miRBase Accession No. MIMAT0009203 ) and other species homologs or orthologs. The 9b-3p gene is Schotte D et al., 2009, Leukemia., Vol. 23 The hsa-miR can be obtained by the method described in -449b-3p is a precursor of hsa-mir-44, which has a hairpin-like structure. 9b" (miRBase Accession No. MI0003673, SEQ ID NO: 6 46) is known.

[0330] As used herein, "hsa-miR-1976 gene" or "hsa-miR-1 The term "miR-1976" refers to the hsa-miR-1976 gene (miR-1976) set forth in SEQ ID NO: 253. RBase Accession No. MIMAT0009451) and other species The hsa-miR-1976 gene is a homologue or ortholog. The method described in ff LA et al., 2009, PLoS One., Vol. 4, e7192 hsa-miR-1976 can be obtained by The miRBase Accession No. hsa-mir-1976 (hsa-mir-1976) has an apin-like structure. n No. MI0009986, sequence number 647) is known.

[0331] As used herein, "hsa-miR-4268 gene" or "hsa-miR-4 The term "miR-4268" refers to the hsa-miR-4268 gene (miR-4268) set forth in SEQ ID NO: 254. RBase Accession No. MIMAT0016896) and other species The hsa-miR-4268 gene is a Go The method described in ff LA et al., 2009, PLoS One., Vol. 4, e7192 hsa-miR-4268 can be obtained by The miRBase Accession No. 100001268 (hsa-mir-4268) has an apin-like structure. n No. MI0015874, sequence number 648) is known.

[0332] As used herein, "hsa-miR-4279 gene" or "hsa-miR-4 The term "miR-4279" refers to the hsa-miR-4279 gene (miR-4279) set forth in SEQ ID NO: 255. RBase Accession No. MIMAT0016909) and other species The hsa-miR-4279 gene is a homologue or ortholog. By the method described in Tten D et al., 2010, BMC Biol., Vol. 8, 58 In addition, "hsa-miR-4279" can be obtained by using hairpin as its precursor. The miRBase Accession No. 100001266664444 has a phosphodiesterase-like structure, "hsa-mir-4279" (miRBase Accession No. 1000012666644444). No. MI0015887, SEQ ID NO: 649) is known.

[0333] As used herein, "hsa-miR-3620-3p gene" or "hsa-mi The term "miR-3620-3p" refers to hsa-miR-3620 set forth in SEQ ID NO: 256. -3p gene (miRBase Accession No. MIMAT0018001 ) and other species homologs or orthologs. The 20-3p gene is described in Witten D et al., 2010, BMC Biol., Vol. 8, No. 5 8. Also, "hsa-miR-3620-3 p” has a hairpin-like structure as its precursor “hsa-mir-3620” (miR Base Accession No. MI0016011, SEQ ID NO: 650) is known are.

[0334] As used herein, the term "hsa-miR-3944-3p gene" or "hsa-mi The term "miR-3944-3p" refers to hsa-miR-3944 set forth in SEQ ID NO: 257. -3p gene (miRBase Accession No. MIMAT0018360 ) and other species homologs or orthologs. The 44-3p gene is Liao JY et al., 2010, PLoS One., Vol. 5, e1 The miR-394 gene can be obtained by the method described in JP 2005-0563. 4-3p" has a hairpin-like structure as its precursor "hsa-mir-3944" ( miRBase Accession No. MI0016601, SEQ ID NO: 651) It is known.

[0335] As used herein, the term "hsa-miR-3156-3p gene" or "hsa-mi The term "miR-3156-3p" refers to hsa-miR-3156 as set forth in SEQ ID NO: 258. -3p gene (miRBase Accession No. MIMAT0019209 ) and other species homologs or orthologs. The 56-3p gene is Stark MS et al., 2010, PLoS One., Vol. 5, e The miR-315 can be obtained by the method described in 9685. 6-3p has a hairpin-like structure as its precursor, hsa-mir-3156-1 , hsa-mir-3156-2” (miRBase Accession No. MI 0014184, MI0014230, SEQ ID NOs: 652, 653) are known.

[0336] As used herein, "hsa-miR-3187-5p gene" or "hsa-mi The term "miR-3187-5p" refers to hsa-miR-3187 set forth in SEQ ID NO: 259. -5p gene (miRBase Accession No. MIMAT0019216 ) and other species homologs or orthologs. The 87-5p gene is described in Stark MS et al., 2010, PLoS One., Vol. 5, e The miR-318 can be obtained by the method described in 9685. 7-5p" has a hairpin-like structure as its precursor "hsa-mir-3187" ( miRBase Accession No. MI0014231, SEQ ID NO: 654) It is known.

[0337] As used herein, "hsa-miR-4685-3p gene" or "hsa-mi The term "miR-4685-3p" refers to hsa-miR-4685 as set forth in SEQ ID NO: 260. -3p gene (miRBase Accession No. MIMAT0019772 ) and other species homologs or orthologs. The 85-3p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4685-3p is a precursor of hsa-mir-46, which has a hairpin-like structure. 85" (miRBase Accession No. MI0017317, SEQ ID NO: 6 55) is known.

[0338] As used herein, "hsa-miR-4695-3p gene" or "hsa-mi The term "miR-4695-3p" refers to hsa-miR-4695 as set forth in SEQ ID NO: 261. -3p gene (miRBase Accession No. MIMAT0019789 ) and other species homologs or orthologs. The 95-3p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4695-3p is a precursor of hsa-mir-46, which has a hairpin-like structure. 95" (miRBase Accession No. MI0017328, SEQ ID NO: 6 56) is known.

[0339] As used herein, "hsa-miR-4697-3p gene" or "hsa-mi The term "miR-4697-3p" refers to hsa-miR-4697 as set forth in SEQ ID NO: 262. -3p gene (miRBase Accession No. MIMAT0019792 ) and other species homologs or orthologs. The 97-3p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4697-3p is a precursor of hsa-mir-46, which has a hairpin-like structure. 97" (miRBase Accession No. MI0017330, SEQ ID NO: 6 57) is known.

[0340] As used herein, "hsa-miR-4713-5p gene" or "hsa-mi The term "miR-4713-5p" refers to hsa-miR-4713 as set forth in SEQ ID NO: 263. -5p gene (miRBase Accession No. MIMAT0019820 ) and other species homologs or orthologs. The 13-5p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4713-5p is a precursor of hsa-mir-47, which has a hairpin-like structure. 13" (miRBase Accession No. MI0017347, SEQ ID NO: 6 58) is known.

[0341] As used herein, "hsa-miR-4723-3p gene" or "hsa-mi The term "miR-4723-3p" refers to hsa-miR-4723 as set forth in SEQ ID NO: 264. -3p gene (miRBase Accession No. MIMAT0019839 ) and other species homologs or orthologs. The 23-3p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4723-3p is a precursor of hsa-mir-47, which has a hairpin-like structure. 23" (miRBase Accession No. MI0017359, SEQ ID NO: 6 59) is known.

[0342] As used herein, the term "hsa-miR-371b-3p gene" or "hsa-mi The term "miR-371b-3p" refers to hsa-miR-371b set forth in SEQ ID NO: 265. -3p gene (miRBase Accession No. MIMAT0019893 ) and other species homologs or orthologs. The 1b-3p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -371b-3p is a precursor of hsa-mir-37, which has a hairpin-like structure. 1b" (miRBase Accession No. MI0017393, SEQ ID NO: 6 60) is known.

[0343] As used herein, "hsa-miR-3151-3p gene" or "hsa-mi The term "miR-3151-3p" refers to hsa-miR-3151 set forth in SEQ ID NO: 266. -3p gene (miRBase Accession No. MIMAT0027026 ) and other species homologs or orthologs. The 51-3p gene is Stark MS et al., 2010, PLoS One., Vol. 5, e The miR-315 can be obtained by the method described in 9685. 1-3p" has a hairpin-like structure as its precursor "hsa-mir-3151" ( miRBase Accession No. MI0014178, SEQ ID NO: 661) It is known.

[0344] As used herein, "hsa-miR-3192-3p gene" or "hsa-mi The term "miR-3192-3p" refers to hsa-miR-3192 as set forth in SEQ ID NO: 267. -3p gene (miRBase Accession No. MIMAT0027027 ) and other species homologs or orthologs. The 92-3p gene is described in Stark MS et al., 2010, PLoS One., Vol. 5, e The miR-319 can be obtained by the method described in 9685. 2-3p" has a hairpin-like structure as its precursor "hsa-mir-3192" ( miRBase Accession No. MI0014237, SEQ ID NO: 662) It is known.

[0345] As used herein, "hsa-miR-6728-3p gene" or "hsa-mi The term "miR-6728-3p" refers to hsa-miR-6728 set forth in SEQ ID NO: 268. -3p gene (miRBase Accession No. MIMAT0027358 ) and other species homologs or orthologs. The 28-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6728-3p has a hairpin-like structure as its precursor, "hsa-mi r-6728" (miRBase Accession No. MI0022573, Column number 663) is known.

[0346] As used herein, "hsa-miR-6736-3p gene" or "hsa-mi The term "miR-6736-3p" refers to hsa-miR-6736 set forth in SEQ ID NO: 269. -3p gene (miRBase Accession No. MIMAT0027374 ) and other species homologs or orthologs. The 36-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6736-3p has a hairpin-like structure as its precursor, "hsa-mi r-6736" (miRBase Accession No. MI0022581, Column number 664) is known.

[0347] As used herein, "hsa-miR-6740-3p gene" or "hsa-mi The term "miR-6740-3p" refers to hsa-miR-6740 set forth in SEQ ID NO: 270. -3p gene (miRBase Accession No. MIMAT0027382 ) and other species homologs or orthologs. The 40-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6740-3p has a hairpin-like structure as its precursor, "hsa-mi r-6740” (miRBase Accession No. MI0022585, Column number 665) is known.

[0348] As used herein, "hsa-miR-6741-3p gene" or "hsa-mi The term "miR-6741-3p" refers to hsa-miR-6741 set forth in SEQ ID NO: 271. -3p gene (miRBase Accession No. MIMAT0027384 ) and other species homologs or orthologs. The 41-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6741-3p has a hairpin-like structure as its precursor, "hsa-mi r-6741" (miRBase Accession No. MI0022586, Column number 666) is known.

[0349] As used herein, "hsa-miR-6743-3p gene" or "hsa-mi The term "miR-6743-3p" refers to hsa-miR-6743 as set forth in SEQ ID NO: 272. -3p gene (miRBase Accession No. MIMAT0027388 ) and other species homologs or orthologs. The 43-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6743-3p has a hairpin-like structure as its precursor, "hsa-mi r-6743" (miRBase Accession No. MI0022588, Column number 599) is known.

[0350] As used herein, "hsa-miR-6747-3p gene" or "hsa-mi The term "miR-6747-3p" refers to hsa-miR-6747 as set forth in SEQ ID NO: 273. -3p gene (miRBase Accession No. MIMAT0027395 ) and other species homologs or orthologs. The 47-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6747-3p has a hairpin-like structure as its precursor, "hsa-mi r-6747” (miRBase Accession No. MI0022592, Column number 667) is known.

[0351] As used herein, "hsa-miR-6750-3p gene" or "hsa-mi The term "miR-6750-3p" refers to hsa-miR-6750 set forth in SEQ ID NO: 274. -3p gene (miRBase Accession No. MIMAT0027401 ) and other species homologs or orthologs. The 50-3p gene is Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6750-3p has a hairpin-like structure as its precursor, "hsa-mi r-6750" (miRBase Accession No. MI0022595, Column number 668) is known.

[0352] As used herein, "hsa-miR-6754-3p gene" or "hsa-mi The term "miR-6754-3p" refers to hsa-miR-6754 set forth in SEQ ID NO: 275. -3p gene (miRBase Accession No. MIMAT0027409 ) and other species homologs or orthologs. The 54-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6754-3p has a hairpin-like structure as its precursor, "hsa-mi r-6754" (miRBase Accession No. MI0022599, Column number 669) is known.

[0353] As used herein, "hsa-miR-6759-3p gene" or "hsa-mi The term "miR-6759-3p" refers to hsa-miR-6759 as set forth in SEQ ID NO: 276. -3p gene (miRBase Accession No. MIMAT0027419 ) and other species homologs or orthologs. The 59-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6759-3p has a hairpin-like structure as its precursor, "hsa-mi r-6759" (miRBase Accession No. MI0022604, Column number 670) is known.

[0354] As used herein, "hsa-miR-6761-3p gene" or "hsa-mi The term "miR-6761-3p" refers to hsa-miR-6761 set forth in SEQ ID NO: 277. -3p gene (miRBase Accession No. MIMAT0027423 ) and other species homologs or orthologs. The 61-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6761-3p has a hairpin-like structure as its precursor, "hsa-mi r-6761” (miRBase Accession No. MI0022606, Column number 671) is known.

[0355] As used herein, "hsa-miR-6762-3p gene" or "hsa-mi The term "miR-6762-3p" refers to hsa-miR-6762 set forth in SEQ ID NO: 278. -3p gene (miRBase Accession No. MIMAT0027425 ) and other species homologs or orthologs. The 62-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6762-3p has a hairpin-like structure as its precursor, "hsa-mi r-6762" (miRBase Accession No. MI0022607, Column number 672) is known.

[0356] As used herein, "hsa-miR-6769a-3p gene" or "hsa-m The term "hsa-miR-6769a-3p" refers to hsa-miR-6769a-3p as set forth in SEQ ID NO: 279. 69a-3p gene (miRBase Accession No. MIMAT0027 439) and other species homologs or orthologs. The -6769a-3p gene is described in Ladewig E et al., 2012, Genome Re s., Vol. 22, pp. 1634-1645. "hsa-miR-6769a-3p" is a precursor of "hsa-miR-6769a-3p" which has a hairpin-like structure. sa-mir-6769a” (miRBase Accession No. MI002 2614, SEQ ID NO: 673) is known.

[0357] As used herein, "hsa-miR-6776-3p gene" or "hsa-mi The term "miR-6776-3p" refers to hsa-miR-6776 set forth in SEQ ID NO: 280. -3p gene (miRBase Accession No. MIMAT0027453 ) and other species homologs or orthologs. The 76-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6776-3p has a hairpin-like structure as its precursor, "hsa-mi r-6776” (miRBase Accession No. MI0022621, Column number 674) is known.

[0358] As used herein, "hsa-miR-6778-3p gene" or "hsa-mi The term "miR-6778-3p" refers to hsa-miR-6778 as set forth in SEQ ID NO: 281. -3p gene (miRBase Accession No. MIMAT0027457 ) and other species homologs or orthologs. The 78-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6778-3p has a hairpin-like structure as its precursor, "hsa-mi r-6778" (miRBase Accession No. MI0022623, Column number 675) is known.

[0359] As used herein, "hsa-miR-6779-3p gene" or "hsa-mi The term "miR-6779-3p" refers to hsa-miR-6779 set forth in SEQ ID NO: 282. -3p gene (miRBase Accession No. MIMAT0027459 ) and other species homologs or orthologs. The 79-3p gene is Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6779-3p has a hairpin-like structure as its precursor, "hsa-mi r-6779” (miRBase Accession No. MI0022624, Column number 676) is known.

[0360] As used herein, "hsa-miR-6786-3p gene" or "hsa-mi The term "miR-6786-3p" refers to hsa-miR-6786 set forth in SEQ ID NO: 283. -3p gene (miRBase Accession No. MIMAT0027473 ) and other species homologs or orthologs. The 86-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6786-3p has a hairpin-like structure as its precursor, "hsa-mi r-6786" (miRBase Accession No. MI0022631, Column number 539) is known.

[0361] As used herein, "hsa-miR-6787-3p gene" or "hsa-mi The term "miR-6787-3p" refers to hsa-miR-6787 set forth in SEQ ID NO: 284. -3p gene (miRBase Accession No. MIMAT0027475 ) and other species homologs or orthologs. The 87-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6787-3p has a hairpin-like structure as its precursor, "hsa-mi r-6787" (miRBase Accession No. MI0022632, Column number 677) is known.

[0362] As used herein, "hsa-miR-6792-3p gene" or "hsa-mi The term "miR-6792-3p" refers to hsa-miR-6792 set forth in SEQ ID NO: 285. -3p gene (miRBase Accession No. MIMAT0027485 ) and other species homologs or orthologs. The 92-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6792-3p has a hairpin-like structure as its precursor, "hsa-mi r-6792" (miRBase Accession No. MI0022637, Column number 678) is known.

[0363] As used herein, "hsa-miR-6794-3p gene" or "hsa-mi The term "miR-6794-3p" refers to hsa-miR-6794 set forth in SEQ ID NO: 286. -3p gene (miRBase Accession No. MIMAT0027489 ) and other species homologs or orthologs. The 94-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6794-3p has a hairpin-like structure as its precursor, "hsa-mi r-6794" (miRBase Accession No. MI0022639, Column number 679) is known.

[0364] As used herein, "hsa-miR-6801-3p gene" or "hsa-mi The term "miR-6801-3p" refers to hsa-miR-6801 set forth in SEQ ID NO: 287. -3p gene (miRBase Accession No. MIMAT0027503 ) and other species homologs or orthologs. The 01-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6801-3p has a hairpin-like structure as its precursor, "hsa-mi r-6801" (miRBase Accession No. MI0022646, Column number 680) is known.

[0365] As used herein, "hsa-miR-6802-3p gene" or "hsa-mi The term "miR-6802-3p" refers to hsa-miR-6802 set forth in SEQ ID NO: 288. -3p gene (miRBase Accession No. MIMAT0027505 ) and other species homologs or orthologs. The 02-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6802-3p has a hairpin-like structure as its precursor, "hsa-mi r-6802" (miRBase Accession No. MI0022647, Column number 681) is known.

[0366] As used herein, "hsa-miR-6803-3p gene" or "hsa-mi The term "miR-6803-3p" refers to hsa-miR-6803 set forth in SEQ ID NO: 289. -3p gene (miRBase Accession No. MIMAT0027507 ) and other species homologs or orthologs. The 03-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6803-3p has a hairpin-like structure as its precursor, "hsa-mi r-6803” (miRBase Accession No. MI0022648, Column number 682) is known.

[0367] As used herein, "hsa-miR-6804-3p gene" or "hsa-mi The term "miR-6804-3p" refers to hsa-miR-6804 set forth in SEQ ID NO: 290. -3p gene (miRBase Accession No. MIMAT0027509 ) and other species homologs or orthologs. The 04-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6804-3p has a hairpin-like structure as its precursor, "hsa-mi r-6804” (miRBase Accession No. MI0022649, Column number 683) is known.

[0368] As used herein, "hsa-miR-6810-5p gene" or "hsa-mi The term "miR-6810-5p" refers to hsa-miR-6810 set forth in SEQ ID NO: 291. -5p gene (miRBase Accession No. MIMAT0027520 ) and other species homologs or orthologs. The 10-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6810-5p has a hairpin-like structure as its precursor, "hsa-mi r-6810" (miRBase Accession No. MI0022655, Column number 684) is known.

[0369] As used herein, "hsa-miR-6823-3p gene" or "hsa-mi The term "miR-6823-3p" refers to hsa-miR-6823 as set forth in SEQ ID NO: 292. -3p gene (miRBase Accession No. MIMAT0027547 ) and other species homologs or orthologs. The 23-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6823-3p has a hairpin-like structure as its precursor, "hsa-mi r-6823" (miRBase Accession No. MI0022668, Column number 550) is known.

[0370] As used herein, "hsa-miR-6825-3p gene" or "hsa-mi The term "miR-6825-3p" refers to hsa-miR-6825 set forth in SEQ ID NO: 293. -3p gene (miRBase Accession No. MIMAT0027551 ) and other species homologs or orthologs. The 25-3p gene is Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6825-3p has a hairpin-like structure as its precursor, "hsa-mi r-6825" (miRBase Accession No. MI0022670, Column number 685) is known.

[0371] As used herein, "hsa-miR-6829-3p gene" or "hsa-mi The term "miR-6829-3p" refers to hsa-miR-6829 set forth in SEQ ID NO: 294. -3p gene (miRBase Accession No. MIMAT0027559 ) and other species homologs or orthologs. The 29-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6829-3p has a hairpin-like structure as its precursor, "hsa-mi r-6829” (miRBase Accession No. MI0022674, Column number 686) is known.

[0372] As used herein, "hsa-miR-6833-3p gene" or "hsa-mi The term "miR-6833-3p" refers to hsa-miR-6833 as set forth in SEQ ID NO: 295. -3p gene (miRBase Accession No. MIMAT0027567 ) and other species homologs or orthologs. The 33-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6833-3p has a hairpin-like structure as its precursor, "hsa-mi r-6833" (miRBase Accession No. MI0022678, Column number 687) is known.

[0373] As used herein, "hsa-miR-6834-3p gene" or "hsa-mi The term "miR-6834-3p" refers to hsa-miR-6834 set forth in SEQ ID NO: 296. -3p gene (miRBase Accession No. MIMAT0027569 ) and other species homologs or orthologs. The 34-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6834-3p has a hairpin-like structure as its precursor, "hsa-mi r-6834" (miRBase Accession No. MI0022679, Column number 688) is known.

[0374] As used herein, "hsa-miR-6780b-3p gene" or "hsa-m The term "miR-6780b-3p" refers to hsa-miR-6780b-3p as set forth in SEQ ID NO: 297. 80b-3p gene (miRBase Accession No. MIMAT0027 573) and other species homologs or orthologs. The -6780b-3p gene is from Ladewig E et al., 2012, Genome Re s., Vol. 22, pp. 1634-1645. "hsa-miR-6780b-3p" is a precursor of "hsa-miR-6780b-3p" which has a hairpin-like structure. sa-mir-6780b” (miRBase Accession No. MI002 2681, sequence number 689) is known.

[0375] As used herein, "hsa-miR-6845-3p gene" or "hsa-mi The term "miR-6845-3p" refers to hsa-miR-6845 set forth in SEQ ID NO: 298. -3p gene (miRBase Accession No. MIMAT0027591 ) and other species homologs or orthologs. The 45-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6845-3p has a hairpin-like structure as its precursor, "hsa-mi r-6845" (miRBase Accession No. MI0022691, Column number 690) is known.

[0376] As used herein, "hsa-miR-6862-3p gene" or "hsa-mi The term "miR-6862-3p" refers to hsa-miR-6862 set forth in SEQ ID NO: 299. -3p gene (miRBase Accession No. MIMAT0027626 ) and other species homologs or orthologs. The 62-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6862-3p has a hairpin-like structure as its precursor, "hsa-mi r-6862-1, hsa-mir-6862-2” (miRBase Accessi on No. MI0022709, MI0026415, sequence numbers 691 and 692) are known It is being done.

[0377] As used herein, "hsa-miR-6865-3p gene" or "hsa-mi The term "miR-6865-3p" refers to hsa-miR-6865 as set forth in SEQ ID NO: 300. -3p gene (miRBase Accession No. MIMAT0027631 ) and other species homologs or orthologs. The 65-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6865-3p has a hairpin-like structure as its precursor, "hsa-mi r-6865” (miRBase Accession No. MI0022712, Column number 693) is known.

[0378] As used herein, "hsa-miR-6870-3p gene" or "hsa-mi The term "miR-6870-3p" refers to hsa-miR-6870 set forth in SEQ ID NO: 301. -3p gene (miRBase Accession No. MIMAT0027641 ) and other species homologs or orthologs. The 70-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6870-3p has a hairpin-like structure as its precursor, "hsa-mi r-6870” (miRBase Accession No. MI0022717, Column number 694) is known.

[0379] As used herein, "hsa-miR-6875-3p gene" or "hsa-mi The term "miR-6875-3p" refers to hsa-miR-6875 as set forth in SEQ ID NO: 302. -3p gene (miRBase Accession No. MIMAT0027651 ) and other species homologs or orthologs. The 75-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6875-3p has a hairpin-like structure as its precursor, "hsa-mi r-6875” (miRBase Accession No. MI0022722, Column number 695) is known.

[0380] As used herein, the term "hsa-miR-6877-3p gene" or "hsa-mi The term "miR-6877-3p" refers to hsa-miR-6877 as set forth in SEQ ID NO: 303. -3p gene (miRBase Accession No. MIMAT0027655 ) and other species homologs or orthologs. The 77-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6877-3p has a hairpin-like structure as its precursor, "hsa-mi r-6877” (miRBase Accession No. MI0022724, Column number 696) is known.

[0381] As used herein, "hsa-miR-6879-3p gene" or "hsa-mi The term "miR-6879-3p" refers to hsa-miR-6879 as set forth in SEQ ID NO: 304. -3p gene (miRBase Accession No. MIMAT0027659 ) and other species homologs or orthologs. The 79-3p gene is Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6879-3p has a hairpin-like structure as its precursor, "hsa-mi r-6879” (miRBase Accession No. MI0022726, Column number 697) is known.

[0382] As used herein, "hsa-miR-6882-3p gene" or "hsa-mi The term "miR-6882-3p" refers to hsa-miR-6882 set forth in SEQ ID NO: 305. -3p gene (miRBase Accession No. MIMAT0027665 ) and other species homologs or orthologs. The 82-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6882-3p has a hairpin-like structure as its precursor, "hsa-mi r-6882" (miRBase Accession No. MI0022729, Column number 698) is known.

[0383] As used herein, the term "hsa-miR-6885-3p gene" or "hsa-mi The term "miR-6885-3p" refers to hsa-miR-6885 set forth in SEQ ID NO: 306. -3p gene (miRBase Accession No. MIMAT0027671 ) and other species homologs or orthologs. The 85-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6885-3p has a hairpin-like structure as its precursor, "hsa-mi r-6885" (miRBase Accession No. MI0022732, Column number 699) is known.

[0384] As used herein, "hsa-miR-6886-3p gene" or "hsa-mi The term "miR-6886-3p" refers to hsa-miR-6886 set forth in SEQ ID NO: 307. -3p gene (miRBase Accession No. MIMAT0027673 ) and other species homologs or orthologs. The 86-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6886-3p has a hairpin-like structure as its precursor, "hsa-mi r-6886" (miRBase Accession No. MI0022733, Column number 700) is known.

[0385] As used herein, "hsa-miR-6887-3p gene" or "hsa-mi The term "miR-6887-3p" refers to hsa-miR-6887 set forth in SEQ ID NO: 308. -3p gene (miRBase Accession No. MIMAT0027675 ) and other species homologs or orthologs. The 87-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6887-3p has a hairpin-like structure as its precursor, "hsa-mi r-6887" (miRBase Accession No. MI0022734, Column number 701) is known.

[0386] As used herein, the term "hsa-miR-6890-3p gene" or "hsa-mi The term "miR-6890-3p" refers to hsa-miR-6890 set forth in SEQ ID NO: 309. -3p gene (miRBase Accession No. MIMAT0027681 ) and other species homologs or orthologs. The 90-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6890-3p has a hairpin-like structure as its precursor, "hsa-mi r-6890" (miRBase Accession No. MI0022737, Column number 702) is known.

[0387] As used herein, the term "hsa-miR-6893-3p gene" or "hsa-mi The term "miR-6893-3p" refers to hsa-miR-6893 as set forth in SEQ ID NO: 310. -3p gene (miRBase Accession No. MIMAT0027687 ) and other species homologs or orthologs. The 93-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6893-3p has a hairpin-like structure as its precursor, "hsa-mi r-6893" (miRBase Accession No. MI0022740, Column number 703) is known.

[0388] As used herein, the term "hsa-miR-6894-3p gene" or "hsa-mi The term "miR-6894-3p" refers to hsa-miR-6894 set forth in SEQ ID NO: 311. -3p gene (miRBase Accession No. MIMAT0027689 ) and other species homologs or orthologs. The 94-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6894-3p has a hairpin-like structure as its precursor, "hsa-mi r-6894" (miRBase Accession No. MI0022741, Column number 704) is known.

[0389] As used herein, "hsa-miR-7106-3p gene" or "hsa-mi The term "miR-7106-3p" refers to hsa-miR-7106 as set forth in SEQ ID NO: 312. -3p gene (miRBase Accession No. MIMAT0028110 ) and other species homologs or orthologs. The 06-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-7106-3p has a hairpin-like structure as its precursor, "hsa-mi r-7106" (miRBase Accession No. MI0022957, Column number 705) is known.

[0390] As used herein, "hsa-miR-7109-3p gene" or "hsa-mi The term "miR-7109-3p" refers to hsa-miR-7109 set forth in SEQ ID NO: 313. -3p gene (miRBase Accession No. MIMAT0028116 ) and other species homologs or orthologs. The 09-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-7109-3p has a hairpin-like structure as its precursor, "hsa-mi r-7109" (miRBase Accession No. MI0022960, Column number 706) is known.

[0391] As used herein, "hsa-miR-7114-3p gene" or "hsa-mi The term "miR-7114-3p" refers to hsa-miR-7114 set forth in SEQ ID NO: 314. -3p gene (miRBase Accession No. MIMAT0028126 ) and other species homologs or orthologs. The 14-3p gene is Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-7114-3p has a hairpin-like structure as its precursor, "hsa-mi r-7114" (miRBase Accession No. MI0022965, Column number 707) is known.

[0392] As used herein, "hsa-miR-7155-5p gene" or "hsa-mi The term "miR-7155-5p" refers to hsa-miR-7155 as set forth in SEQ ID NO: 315. -5p gene (miRBase Accession No. MIMAT0028220 ) and other species homologs or orthologs. The 55-5p gene is described in Meunier J et al., 2013, Genome Res., 2 3, pp. 34-45. -7155-5p is a precursor of hsa-mir-71, which has a hairpin-like structure. 55" (miRBase Accession No. MI0023615, SEQ ID NO: 7 08) is known.

[0393] As used herein, "hsa-miR-7160-5p gene" or "hsa-mi The term "miR-7160-5p" refers to hsa-miR-7160 set forth in SEQ ID NO: 316. -5p gene (miRBase Accession No. MIMAT0028230 ) and other species homologs or orthologs. The 60-5p gene is described in Meunier J et al., 2013, Genome Res., 2 3, pp. 34-45. -7160-5p is a precursor of hsa-mir-71, which has a hairpin-like structure. 60" (miRBase Accession No. MI0023621, SEQ ID NO: 7 09) is known.

[0394] As used herein, "hsa-miR-615-3p gene" or "hsa-miR The term "miR-615-3p" refers to hsa-miR-615-3p set forth in SEQ ID NO: 317. Gene (miRBase Accession No. MIMAT0003283) and This includes homologs or orthologs of hsa-miR-615-3 in other species. The p gene is described in Cummins JM et al., 2006, Proc Natl Acad S ci US A., Vol. 103, 3687-3692 In addition, "hsa-miR-615-3p" has a hairpin-like structure as its precursor. The miRBase Accession No. I0003628, SEQ ID NO: 710) is known.

[0395] As used herein, "hsa-miR-920 gene" or "hsa-miR-92 The term "miR-920" refers to the hsa-miR-920 gene (miRBa se Accession No. MIMAT0004970) and other species homologs The hsa-miR-920 gene is available from Novotn y GW et al., 2007, Int J Androl., 30, 316-326 Furthermore, "hsa-miR-920" can be obtained by the method described above. The miRBase Accession No. 10001266666, which has a hairpin-like structure as its base, is designated "hsa-mir-920" (miRBase Accession No. 1000126666666). The sequence number of the nucleotide sequence ...

[0396] As used herein, "hsa-miR-1825 gene" or "hsa-miR-1 The term "miR-1825" refers to the hsa-miR-1825 gene (miR-1825) set forth in SEQ ID NO: 319. RBase Accession No. MIMAT0006765) and other species The hsa-miR-1825 gene is a homologue or ortholog of the Fr Iedlander MR et al., 2008, Nat Biotechnol., vol. 26, The "hsa-miR- 1825" has a hairpin-like structure as its precursor, "hsa-mir-1825" ( miRBase Accession No. MI0008193, SEQ ID NO: 712) It is known.

[0397] As used herein, "hsa-miR-675-3p gene" or "hsa-miR The term "miR-675-3p" refers to hsa-miR-675-3p set forth in SEQ ID NO: 320. Gene (miRBase Accession No. MIMAT0006790) and This includes homologs or orthologs of hsa-miR-675-3 in other species. The p gene is described in Cai X et al., 2007, RNA., Vol. 13, 313-316. hsa-miR-675-3p can be obtained by the method The miRBase Accelerator, "hsa-mir-675" (miRBase Accelerator), has a hairpin-like structure. Session No. MI0005416, SEQ ID NO: 713) is known.

[0398] As used herein, "hsa-miR-1910-5p gene" or "hsa-mi The term "miR-1910-5p" refers to hsa-miR-1910 set forth in SEQ ID NO: 321. -5p gene (miRBase Accession No. MIMAT0007884 ) and other species homologs or orthologs. The 10-5p gene is Bar M et al., 2008, Stem Cells., Vol. 26, No. 2 The hsa-miR can be obtained by the method described in JP 496-2505. -1910-5p is a precursor of hsa-mir-19, which has a hairpin-like structure. 10" (miRBase Accession No. MI0008331, SEQ ID NO: 7 14) is known.

[0399] As used herein, "hsa-miR-2278 gene" or "hsa-miR-2 The term "miR-2278" refers to the hsa-miR-2278 gene (miR-2278) set forth in SEQ ID NO: 322. RBase Accession No. MIMAT0011778) and other species The hsa-miR-2278 gene is a homologue or ortholog of the Ny Gaard S et al., 2009, BMC Med Genomics., Vol. 2, No. 35 hsa-miR-2278 can be obtained by the method described in the The precursor of "hsa-mir-2278" (miRBase A Accession No. MI0011285, SEQ ID NO: 715) is known.

[0400] As used herein, "hsa-miR-2682-3p gene" or "hsa-mi The term "miR-2682-3p" refers to hsa-miR-2682 set forth in SEQ ID NO: 323. -3p gene (miRBase Accession No. MIMAT0013518 ) and other species homologs or orthologs. The 82-3p gene is Creighton CJ et al., 2010, PLoS One. 5, e9637. -2682-3p is a precursor of hsa-mir-26, which has a hairpin-like structure. 82" (miRBase Accession No. MI0012063, SEQ ID NO: 7 16) is known.

[0401] As used herein, "hsa-miR-3122 gene" or "hsa-miR-3 The term "miR-3122" refers to the hsa-miR-3122 gene (miR-3122) set forth in SEQ ID NO: 324. RBase Accession No. MIMAT0014984) and other species The hsa-miR-3122 gene is a homologue or ortholog of the St The method described in ark MS et al., 2010, PLoS One., Vol. 5, e9685 Furthermore, "hsa-miR-3122" can be obtained as its precursor. The hairpin-like structure of "hsa-mir-3122" (miRBase Accession No. on No. MI0014138, SEQ ID NO: 717) is known.

[0402] As used herein, "hsa-miR-3151-5p gene" or "hsa-mi The term "miR-3151-5p" refers to hsa-miR-3151 set forth in SEQ ID NO: 325. -5p gene (miRBase Accession No. MIMAT0015024 ) and other species homologs or orthologs. The 51-5p gene is Stark MS et al., 2010, PLoS One., Vol. 5, e The miR-315 can be obtained by the method described in 9685. 1-5p" has a hairpin-like structure as its precursor "hsa-mir-3151" ( miRBase Accession No. MI0014178, SEQ ID NO: 661) It is known.

[0403] As used herein, "hsa-miR-3175 gene" or "hsa-miR-3 The term "miR-3175" refers to the hsa-miR-3175 gene (miR-3175) set forth in SEQ ID NO: 326. RBase Accession No. MIMAT0015052) and other species The hsa-miR-3175 gene is a homologue or ortholog of the Cr Eighton CJ et al., 2010, PLoS One., Vol. 5, e9637 hsa-miR-3175 can be obtained by the method described above. The miRBase Accelerator has a hairpin-like structure called "hsa-mir-3175" ( Session No. MI0014209, SEQ ID NO: 718) is known.

[0404] As used herein, "hsa-miR-4323 gene" or "hsa-miR-4 The term "miR-4323" refers to the hsa-miR-4323 gene (miR-4323) set forth in SEQ ID NO: 327. RBase Accession No. MIMAT0016875) and other species The hsa-miR-4323 gene is a homologue or ortholog. The method described in ff LA et al., 2009, PLoS One., Vol. 4, e7192 hsa-miR-4323 can be obtained as a precursor of The miRBase Accession No. 1001266666 (hsa-mir-4323) has an apin-like structure. n No. MI0015853, sequence number 719) is known.

[0405] As used herein, "hsa-miR-4326 gene" or "hsa-miR-4 The term "miR-4326" refers to the hsa-miR-4326 gene (miR-4326) set forth in SEQ ID NO: 328. RBase Accession No. MIMAT0016888) and other species The hsa-miR-4326 gene is a homologue or ortholog. The method described in ff LA et al., 2009, PLoS One., Vol. 4, e7192 hsa-miR-4326 can be obtained by The miRBase Accession No. 10000126444 (hsa-mir-4326) has an apin-like structure. n No. MI0015866, SEQ ID NO: 720) is known.

[0406] As used herein, "hsa-miR-4284 gene" or "hsa-miR-4 The term "miR-4284" refers to the hsa-miR-4284 gene (miR-4284) set forth in SEQ ID NO: 329. RBase Accession No. MIMAT0016915) and other species The hsa-miR-4284 gene is a homologue or ortholog. The method described in ff LA et al., 2009, PLoS One., Vol. 4, e7192 hsa-miR-4284 can be obtained by The apin-like structure of "hsa-mir-4284" (miRBase Accession No. 1001001001001) n No. MI0015893, sequence number 721) is known.

[0407] As used herein, "hsa-miR-3605-3p gene" or "hsa-mi The term "miR-3605-3p" refers to hsa-miR-3605 as set forth in SEQ ID NO: 330. -3p gene (miRBase Accession No. MIMAT0017982 ) and other species homologs or orthologs. The 05-3p gene is described in Creighton CJ et al., 2010, PLoS One. 5, e9637. -3605-3p is a precursor of hsa-mir-36, which has a hairpin-like structure. 05" (miRBase Accession No. MI0015995, SEQ ID NO: 7 22) is known.

[0408] As used herein, "hsa-miR-3622b-5p gene" or "hsa-m The term "miR-3622b-5p" refers to hsa-miR-3622b-5p as set forth in SEQ ID NO: 331. 22b-5p gene (miRBase Accession No. MIMAT0018 005) and other species homologs or orthologs. The -3622b-5p gene is described in Witten D et al., 2010, BMC Biol. 8, 58. 22b-5p is a precursor of hsa-mir-3622, which has a hairpin-like structure. b" (miRBase Accession No. MI0016014, SEQ ID NO: 72 3) is known.

[0409] As used herein, "hsa-miR-3646 gene" or "hsa-miR-3 The term "miR-3646" refers to the hsa-miR-3646 gene (miR-3646) set forth in SEQ ID NO: 332. RBase Accession No. MIMAT0018065) ​​and other species The hsa-miR-3646 gene is a homologue or ortholog of the Me iri E et al., 2010, Nucleic Acids Res., Vol. 38, 6234 The miR-36 can be obtained by the method described in US Pat. No. 6,246,624. 46" has a hairpin-like structure as its precursor, "hsa-mir-3646" (mi RBase Accession No. MI0016046, sequence number 724) It is being done.

[0410] As used herein, "hsa-miR-3158-5p gene" or "hsa-mi The term "miR-3158-5p" refers to hsa-miR-3158 as set forth in SEQ ID NO: 333. -5p gene (miRBase Accession No. MIMAT0019211 ) and other species homologs or orthologs. The 58-5p gene is Creighton CJ et al., 2010, PLoS One. 5, e9637. -3158-5p is a precursor of hsa-mir-31, which has a hairpin-like structure. 58-1, hsa-mir-3158-2” (miRBase Accession N o.MI0014186, MI0014187, SEQ ID NOs: 725, 726) are known do.

[0411] As used herein, "hsa-miR-4722-3p gene" or "hsa-mi The term "miR-4722-3p" refers to hsa-miR-4722 as set forth in SEQ ID NO: 334. -3p gene (miRBase Accession No. MIMAT0019837 ) and other species homologs or orthologs. The 22-3p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4722-3p is a precursor of hsa-mir-47, which has a hairpin-like structure. 22" (miRBase Accession No. MI0017357, SEQ ID NO: 7 27) is known.

[0412] As used herein, "hsa-miR-4728-3p gene" or "hsa-mi The term "miR-4728-3p" refers to hsa-miR-4728 as set forth in SEQ ID NO: 335. -3p gene (miRBase Accession No. MIMAT0019850 ) and other species homologs or orthologs. The 28-3p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4728-3p is a precursor of hsa-mir-47, which has a hairpin-like structure. 28" (miRBase Accession No. MI0017365, SEQ ID NO: 3 93) is known.

[0413] As used herein, "hsa-miR-4747-3p gene" or "hsa-mi The term "miR-4747-3p" refers to hsa-miR-4747 as set forth in SEQ ID NO: 336. -3p gene (miRBase Accession No. MIMAT0019883 ) and other species homologs or orthologs. The 47-3p gene is described in Persson H et al., 2011, Cancer Res., 7 1, pp. 78-86. -4747-3p is a precursor of hsa-mir-47, which has a hairpin-like structure. 47" (miRBase Accession No. MI0017386, SEQ ID NO: 7 28) is known.

[0414] As used herein, "hsa-miR-4436b-5p gene" or "hsa-m The term "miR-4436b-5p" refers to hsa-miR-4436b-5p as set forth in SEQ ID NO: 337. 36b-5p gene (miRBase Accession No. MIMAT0019 940) and other species homologs or orthologs. The -4436b-5p gene is described in Persson H et al., 2011, Cancer Re s., Vol. 71, pp. 78-86. -miR-4436b-5p has a hairpin-like structure as its precursor, "hsa-m ir-4436b-1, hsa-mir-4436b-2” (miRBase Acce Sequence No. MI0017425, MI0019110, sequence numbers 729 and 730 ) is known.

[0415] As used herein, "hsa-miR-5196-3p gene" or "hsa-mi The term "miR-5196-3p" refers to hsa-miR-5196 as set forth in SEQ ID NO: 338. -3p gene (miRBase Accession No. MIMAT0021129 ) and other species homologs or orthologs. The 96-3p gene is Schotte D et al., 2011, Leukemia., Vol. 25 , 1389-1399. iR-5196-3p is a precursor of the hairpin-like structure known as hsa-mir- 5196" (miRBase Accession No. MI0018175, sequence no. No. 731) is known.

[0416] As used herein, "hsa-miR-5589-5p gene" or "hsa-mi The term "miR-5589-5p" refers to hsa-miR-5589 set forth in SEQ ID NO: 339. -5p gene (miRBase Accession No. MIMAT0022297 ) and other species homologs or orthologs. The 89-5p gene is described in Friedlander MR et al., 2012, Nucleic Acids Res., Vol. 40, 37-52 In addition, "hsa-miR-5589-5p" has a hairpin-like structure as its precursor. The miRBase Accession No. "hsa-mir-5589" (MIRBase Accession No. MI0 019148, SEQ ID NO: 732) is known.

[0417] As used herein, "hsa-miR-345-3p gene" or "hsa-miR The term "miR-345-3p" refers to hsa-miR-345-3p set forth in SEQ ID NO: 340. Gene (miRBase Accession No. MIMAT0022698) and This includes homologs or orthologs of hsa-miR-345-3 in other species. The p gene is described in Kim J et al., 2004, Proc Natl Acad Sci U S A., Vol. 101, pp. 360-365. The precursor of "hsa-miR-345-3p" is "hs a-mir-345” (miRBase Accession No. MI000082 5, SEQ ID NO: 615) is known.

[0418] As used herein, "hsa-miR-642b-5p gene" or "hsa-mi The term "miR-642b-5p" refers to hsa-miR-642b as set forth in SEQ ID NO: 341. -5p gene (miRBase Accession No. MIMAT0022736 ) and other species homologs or orthologs. The 2b-5p gene is described in Witten D et al., 2010, BMC Biol., Vol. 8, No. 5 8. Also, "hsa-miR-642b-5" can be obtained by the method described in p” has a hairpin-like structure as its precursor, “hsa-mir-642b” (miR Base Accession No. MI0016685, SEQ ID NO: 733) is known are.

[0419] As used herein, "hsa-miR-6716-3p gene" or "hsa-mi The term "miR-6716-3p" refers to hsa-miR-6716 set forth in SEQ ID NO: 342. -3p gene (miRBase Accession No. MIMAT0025845 ) and other species homologs or orthologs. The 16-3p gene is Li Y et al., 2012, Gene., Vol. 497, 330-335 The miR-6716-3p gene can be obtained by the method described in " has a hairpin-like structure as its precursor "hsa-mir-6716" (miRB The enzyme (Accession No. MI0022550, SEQ ID NO: 734) is known There are.

[0420] As used herein, "hsa-miR-6511b-3p gene" or "hsa-m The term "miR-6511b-3p" refers to hsa-miR-65 as set forth in SEQ ID NO: 343. 11b-3p gene (miRBase Accession No. MIMAT0025 848) and other species homologs or orthologs. The -6511b-3p gene is described in Li Y et al., 2012, Gene., Vol. 497, No. 330 The miR-651 can be obtained by the method described in Ref. 335. 1b-3p has a hairpin-like structure as its precursor, hsa-mir-6511b -1, hsa-mir-6511b-2” (miRBase Accession No. .MI0022552, MI0023431, sequence numbers 735 and 736) are known .

[0421] As used herein, "hsa-miR-208a-5p gene" or "hsa-mi The term "miR-208a-5p" refers to hsa-miR-208a set forth in SEQ ID NO: 344. -5p gene (miRBase Accession No. MIMAT0026474 ) and other species homologs or orthologs. The 8a-5p gene is Lagos-Quintana M et al., 2003, RNA., 9 It can be obtained by the method described in Vol. 175-179. R-208a-5p is a precursor of hsa-mir-2, which has a hairpin-like structure. 08a" (miRBase Accession No. MI0000251, SEQ ID NO: 737) is known.

[0422] As used herein, "hsa-miR-6726-3p gene" or "hsa-mi The term "miR-6726-3p" refers to hsa-miR-6726 set forth in SEQ ID NO: 345. -3p gene (miRBase Accession No. MIMAT0027354 ) and other species homologs or orthologs. The 26-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6726-3p has a hairpin-like structure as its precursor, "hsa-mi r-6726" (miRBase Accession No. MI0022571, Column number 600) is known.

[0423] As used herein, "hsa-miR-6744-5p gene" or "hsa-mi The term "miR-6744-5p" refers to hsa-miR-6744 set forth in SEQ ID NO: 346. -5p gene (miRBase Accession No. MIMAT0027389 ) and other species homologs or orthologs. The 44-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6744-5p has a hairpin-like structure as its precursor, "hsa-mi r-6744” (miRBase Accession No. MI0022589, Column number 738) is known.

[0424] As used herein, "hsa-miR-6782-3p gene" or "hsa-mi The term "miR-6782-3p" refers to hsa-miR-6782 set forth in SEQ ID NO: 347. -3p gene (miRBase Accession No. MIMAT0027465 ) and other species homologs or orthologs. The 82-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6782-3p has a hairpin-like structure as its precursor, "hsa-mi r-6782” (miRBase Accession No. MI0022627, Column number 739) is known.

[0425] As used herein, "hsa-miR-6789-3p gene" or "hsa-mi The term "miR-6789-3p" refers to hsa-miR-6789 set forth in SEQ ID NO: 348. -3p gene (miRBase Accession No. MIMAT0027479 ) and other species homologs or orthologs. The 89-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6789-3p has a hairpin-like structure as its precursor, "hsa-mi r-6789" (miRBase Accession No. MI0022634, Column number 740) is known.

[0426] As used herein, "hsa-miR-6797-3p gene" or "hsa-mi The term "miR-6797-3p" refers to hsa-miR-6797 set forth in SEQ ID NO: 349. -3p gene (miRBase Accession No. MIMAT0027495 ) and other species homologs or orthologs. The 97-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6797-3p has a hairpin-like structure as its precursor, "hsa-mi r-6797" (miRBase Accession No. MI0022642, Column number 741) is known.

[0427] As used herein, "hsa-miR-6800-3p gene" or "hsa-mi The term "miR-6800-3p" refers to the hsa-miR-6800 gene set forth in SEQ ID NO: 350. -3p gene (miRBase Accession No. MIMAT0027501 ) and other species homologs or orthologs. The 00-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6800-3p has a hairpin-like structure as its precursor, "hsa-mi r-6800” (miRBase Accession No. MI0022645, Column number 491) is known.

[0428] As used herein, "hsa-miR-6806-5p gene" or "hsa-mi The term "miR-6806-5p" refers to hsa-miR-6806 set forth in SEQ ID NO: 351. -5p gene (miRBase Accession No. MIMAT0027512 ) and other species homologs or orthologs. The 06-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6806-5p has a hairpin-like structure as its precursor, "hsa-mi r-6806" (miRBase Accession No. MI0022651, Column number 742) is known.

[0429] As used herein, "hsa-miR-6824-3p gene" or "hsa-mi The term "miR-6824-3p" refers to hsa-miR-6824 set forth in SEQ ID NO: 352. -3p gene (miRBase Accession No. MIMAT0027549 ) and other species homologs or orthologs. The 24-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6824-3p has a hairpin-like structure as its precursor, "hsa-mi r-6824" (miRBase Accession No. MI0022669, Column number 743) is known.

[0430] As used herein, "hsa-miR-6837-5p gene" or "hsa-mi The term "miR-6837-5p" refers to hsa-miR-6837 set forth in SEQ ID NO: 353. -5p gene (miRBase Accession No. MIMAT0027576 ) and other species homologs or orthologs. The 37-5p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6837-5p has a hairpin-like structure as its precursor, "hsa-mi r-6837" (miRBase Accession No. MI0022683, Column number 744) is known.

[0431] As used herein, "hsa-miR-6846-3p gene" or "hsa-mi The term "miR-6846-3p" refers to hsa-miR-6846 as set forth in SEQ ID NO: 354. -3p gene (miRBase Accession No. MIMAT0027593 ) and other species homologs or orthologs. The 46-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6846-3p has a hairpin-like structure as its precursor, "hsa-mi r-6846” (miRBase Accession No. MI0022692, Column number 745) is known.

[0432] As used herein, "hsa-miR-6858-3p gene" or "hsa-mi The term "miR-6858-3p" refers to hsa-miR-6858 as set forth in SEQ ID NO: 355. -3p gene (miRBase Accession No. MIMAT0027617 ) and other species homologs or orthologs. The 58-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6858-3p has a hairpin-like structure as its precursor, "hsa-mi r-6858" (miRBase Accession No. MI0022704, Column number 746) is known.

[0433] As used herein, "hsa-miR-6859-3p gene" or "hsa-mi The term "miR-6859-3p" refers to hsa-miR-6859 set forth in SEQ ID NO: 356. -3p gene (miRBase Accession No. MIMAT0027619 ) and other species homologs or orthologs. The 59-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6859-3p has a hairpin-like structure as its precursor, "hsa-mi r-6859-1, hsa-mir-6859-2, hsa-mir-6859-3, h sa-mir-6859-4” (miRBase Accession No. MI00 22705, MI0026420, MI0026421, MI0031521, SEQ ID NO: 747, 748, 749, 750) are known.

[0434] As used herein, "hsa-miR-6861-3p gene" or "hsa-mi The term "miR-6861-3p" refers to hsa-miR-6861 set forth in SEQ ID NO: 357. -3p gene (miRBase Accession No. MIMAT0027624 ) and other species homologs or orthologs. The 61-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6861-3p has a hairpin-like structure as its precursor, "hsa-mi r-6861” (miRBase Accession No. MI0022708, Column number 596) is known.

[0435] As used herein, "hsa-miR-6880-3p gene" or "hsa-mi The term "miR-6880-3p" refers to hsa-miR-6880 set forth in SEQ ID NO: 358. -3p gene (miRBase Accession No. MIMAT0027661 ) and other species homologs or orthologs. The 80-3p gene is Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6880-3p has a hairpin-like structure as its precursor, "hsa-mi r-6880” (miRBase Accession No. MI0022727, Column number 751) is known.

[0436] As used herein, "hsa-miR-7111-3p gene" or "hsa-mi The term "miR-7111-3p" refers to hsa-miR-7111 set forth in SEQ ID NO: 359. -3p gene (miRBase Accession No. MIMAT0028120 ) and other species homologs or orthologs. The 11-3p gene is Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-7111-3p has a hairpin-like structure as its precursor, "hsa-mi r-7111" (miRBase Accession No. MI0022962, Column number 752) is known.

[0437] As used herein, "hsa-miR-7152-5p gene" or "hsa-mi The term "miR-7152-5p" refers to hsa-miR-7152 as set forth in SEQ ID NO: 360. -5p gene (miRBase Accession No. MIMAT0028214 ) and other species homologs or orthologs. The 52-5p gene is described in Meunier J et al., 2013, Genome Res., 2 3, pp. 34-45. -7152-5p is a precursor of hsa-mir-71, which has a hairpin-like structure. 52" (miRBase Accession No. MI0023612, SEQ ID NO: 7 53) is known.

[0438] As used herein, "hsa-miR-642a-5p gene" or "hsa-mi The term "miR-642a-5p" refers to hsa-miR-642a set forth in SEQ ID NO: 361. -5p gene (miRBase Accession No. MIMAT0003312 ) and other species homologs or orthologs. The 2a-5p gene is described in Cummins JM et al., 2006, Proc Natl Ac Ad Sci U S A., Vol. 103, 3687-3692 Furthermore, "hsa-miR-642a-5p" can be obtained as a precursor of hsa-miR-642a-5p. The apin-like structure of "hsa-mir-642a" (miRBase Accession No. 1001001001001) n No. MI0003657, sequence number 754) is known.

[0439] As used herein, "hsa-miR-657 gene" or "hsa-miR-65 The term "miR-657" refers to the hsa-miR-657 gene (miRBa se Accession No. MIMAT0003335) and other species homologs The hsa-miR-657 gene is a member of the Cumming s JM et al., 2006, Proc Natl Acad Sci U S A., 10 3, pp. 3687-3692. -miR-657 has a hairpin-like structure as its precursor, hsa-mir-65 7" (miRBase Accession No. MI0003681, SEQ ID NO: 75 5) is known.

[0440] As used herein, "hsa-miR-1236-3p gene" or "hsa-mi The term "miR-1236-3p" refers to hsa-miR-1236 as set forth in SEQ ID NO: 363. -3p gene (miRBase Accession No. MIMAT0005591 ) and other species homologs or orthologs. The 36-3p gene is described in Berezikov E et al., 2007, Mol Cell., 2 8, pp. 328-336. iR-1236-3p is a precursor of the hairpin-like structure known as hsa-mir- 1236" (miRBase Accession No. MI0006326, sequence no. No. 756) is known.

[0441] As used herein, "hsa-miR-764 gene" or "hsa-miR-76 The term "miR-764" refers to the hsa-miR-764 gene (miRBa se Accession No. MIMAT0010367) and other species homologs The hsa-miR-764 gene is a member of the Berezi kov E et al., 2006, Genome Res., 16, 1289-1298 hsa-miR-764 can be obtained by the method described in the literature. The miRBase Accelerator, "hsa-mir-764" (miRBase Accelerator), has a hairpin-like structure. Session No. MI0003944, SEQ ID NO: 757) is known.

[0442] As used herein, "hsa-miR-4314 gene" or "hsa-miR-4 The term "miR-4314" refers to the hsa-miR-4314 gene (miR-4314) set forth in SEQ ID NO: 365. RBase Accession No. MIMAT0016868) and other species The hsa-miR-4314 gene is a Go The method described in ff LA et al., 2009, PLoS One., Vol. 4, e7192 hsa-miR-4314 can be obtained as a precursor of The miRBase Accession No. 1001266666, which has an apin-like structure, is a member of the miRBase Accession No. 100126 .... n No. MI0015846, sequence number 758) is known.

[0443] As used herein, the term "hsa-miR-3675-3p gene" or "hsa-mi The term "miR-3675-3p" refers to hsa-miR-3675 as set forth in SEQ ID NO: 366. -3p gene (miRBase Accession No. MIMAT0018099 ) and other species homologs or orthologs. The 75-3p gene is Vaz C et al., 2010, BMC Genomics., Vol. 11 The miR-367 gene can be obtained by the method described in the Japanese Patent Application Laid-Open No. 2002-28854. 5-3p" has a hairpin-like structure as its precursor "hsa-mir-3675" ( miRBase Accession No. MI0016076, SEQ ID NO: 759) It is known.

[0444] As used herein, "hsa-miR-5703 gene" or "hsa-miR-5 The term "miR-5703" refers to the hsa-miR-5703 gene (miR-5703) set forth in SEQ ID NO: 367. RBase Accession No. MIMAT0022496) and other species The hsa-miR-5703 gene is a homologue or ortholog. Tahiki A et al., 2011, PLoS One., Vol. 6, e24950 Furthermore, "hsa-miR-5703" can be obtained by the method described above. The miRBase Accession No. 10000266664444444444 has a hairpin-like structure as a target protein. The sequence number of the nucleotide sequence ...

[0445] As used herein, "hsa-miR-3191-5p gene" or "hsa-mi The term "miR-3191-5p" refers to hsa-miR-3191 set forth in SEQ ID NO: 368. -5p gene (miRBase Accession No. MIMAT0022732 ) and other species homologs or orthologs. The 91-5p gene is described in Stark MS et al., 2010, PLoS One., Vol. 5, e The miR-319 can be obtained by the method described in 9685. 1-5p" has a hairpin-like structure as its precursor "hsa-mir-3191" ( miRBase Accession No. MI0014236, SEQ ID NO: 761) It is known.

[0446] As used herein, "hsa-miR-6511a-3p gene" or "hsa-m The term "miR-6511a-3p" refers to hsa-miR-65 as set forth in SEQ ID NO: 369. 11a-3p gene (miRBase Accession No. MIMAT0025 479) and other species homologs or orthologs. The -6511a-3p gene is Joyce CE et al., 2011, Hum Mol Ge net., Vol. 20, pp. 4025-4040. In addition, "hsa-miR-6511a-3p" has a hairpin-like structure as its precursor. "hsa-mir-6511a-1" (miRBase Accession No.M I0022223, SEQ ID NO: 445) is known.

[0447] As used herein, "hsa-miR-6809-3p gene" or "hsa-mi The term "miR-6809-3p" refers to hsa-miR-6809 set forth in SEQ ID NO: 370. -3p gene (miRBase Accession No. MIMAT0027519 ) and other species homologs or orthologs. The 09-3p gene is described in Ladewig E et al., 2012, Genome Res., 2 2, 1634-1645. -miR-6809-3p has a hairpin-like structure as its precursor, "hsa-mi r-6809"...

Claims

1. A kit for detecting dementia, comprising a detection nucleic acid, The kit, wherein the detection nucleic acid is a nucleic acid probe capable of specifically binding to each of the polynucleotides of miR-4486, miR-6088, and miR-211-5p, which are dementia markers, and / or a primer for specifically recognizing and amplifying the polynucleotide.

2. The detection nucleic acid A polynucleotide selected from the group consisting of (a) to (d) below: (a) a polynucleotide consisting of the base sequence represented by SEQ ID NO: 23 or the base sequence in which u is replaced with t, a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment of any of these containing 15 or more consecutive bases; (b) a polynucleotide comprising the base sequence represented by SEQ ID NO: 23; (c) a polynucleotide consisting of a base sequence complementary to the base sequence represented by SEQ ID NO: 23 or the base sequence in which u is t, a polynucleotide consisting of a base sequence having 90% or more percent identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment containing 15 or more consecutive bases of any of these; and (d) a polynucleotide comprising a base sequence complementary to the base sequence represented by SEQ ID NO: 23 or the base sequence in which u is t; A polynucleotide selected from the group consisting of (a1) to (d1) below: (a1) a polynucleotide consisting of the base sequence represented by SEQ ID NO: 26 or the base sequence in which u is replaced with t, a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment of any of these containing 15 or more consecutive bases; (b1) a polynucleotide comprising the base sequence represented by SEQ ID NO: 26; (c1) A polynucleotide consisting of a base sequence complementary to the base sequence represented by SEQ ID NO: 26 or the base sequence in which u is t, a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment containing 15 or more consecutive bases of any of these, and (d1) a polynucleotide comprising a base sequence complementary to the base sequence represented by SEQ ID NO: 26 or the base sequence in which u is t; and A polynucleotide selected from the group consisting of (a2) to (d2) below: (a2) a polynucleotide consisting of the base sequence represented by SEQ ID NO: 214 or the base sequence in which u is t, a polynucleotide consisting of a base sequence having 90% or more percent identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment containing 15 or more consecutive bases of any of these, (b2) a polynucleotide comprising the base sequence represented by SEQ ID NO: 214; (c2) a polynucleotide consisting of a base sequence complementary to the base sequence represented by SEQ ID NO: 214 or the base sequence in which u is t, a polynucleotide consisting of a base sequence having 90% or more percent identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment containing 15 or more consecutive bases of any of these; and (d2) a polynucleotide comprising a base sequence complementary to the base sequence represented by SEQ ID NO: 214 or the base sequence in which u is t; The kit of claim 1, wherein

3. Another dementia marker, miR-4274, miR-4272, miR-4728-5p, miR-4443, miR-4506, miR-6773-5p, miR-4662a-5p, miR-3184-3p, miR-4281, miR-320d, miR-6729-3p, miR-5192, miR-6853-5p, miR-1234-3p, miR-1233-3p, miR-4539, miR-3914, miR-4738-5p, miR-548au-3p, miR-1539, miR-4720-3p, miR-365b-5p, miR-1227-5p, miR-4667-5p, miR-6820-5p, miR-4505, miR-548q, miR-4658, miR-450a-5p, miR-1260b, miR-3677-5p, miR-6777-3p, miR-6826-3p, miR-6832-3p, miR-4725-3p, miR-7161-3p, miR-2277-5p, miR-7110-3p, miR-4312, miR-4461, miR-6766-5p, miR-1266-3p, miR-6729-5p, miR-526b-3p, miR-519e-5p, miR-512-5p, miR-5088-5p, miR-1909-3p, miR-6511a-5p, miR-4734, miR-936, miR-1249-3p, miR-6777-5p, miR-4487, miR-3155a, miR-563, miR-4741, miR-6788-5p, miR-4433b-5p, miR-323a-5p, miR-6811-5p, miR-6721-5p, miR-5004-5p, miR-6509-3p, miR-648, miR-3917, miR-6087, miR-1470, miR-586, miR-3150a-5p, miR-105-3p, miR-7973, miR-1914-5p, miR-4749-3p, miR-15b-5p, miR-1289, miR-4433a-5p, miR-3666, miR-3186-3p, miR-4725-5p, miR-4488, miR-4474-3p, miR-6731-3p, miR-4640-3p, miR-202-5p, miR-6816-5p, miR-638, miR-6821-5p, miR-1247-3p, miR-6765-5pmiR-6800-5p、miR-3928-3p、miR-3940-5p、miR-3960、miR-6775-5p、miR-3 1888、miR-1202、miR-6790-5p、miR-4731-3p、miR-26811-3p、miR-6758-5p、mi R-8072、miR-518d-3p、miR-3606-3p、miR-4800-5p、miR-1292-3p、miR-678 4-3p、miR-4450、miR-6132、miR-4716-5p、miR-6860、miR-1268b、miR-378d、 miR-4701-5p、miR-4329、miR-185-3p、miR-552-3p、miR-1273g-5p、miR-67 69b-3p、miR-520a-3p、miR-4524b-5p、miR-42911、miR-6734-3p、miR-143-5p 、miR-939-3p、miR-6889-3p、miR-6842-3p、miR-451111、miR-43118、miR-4653 -5p、miR-6867-3p、miR-133b、miR-3196、miR-193b-3p、miR-3162-3p、miR-6 8119-3p、miR-1908-3p、miR-6786-5p、miR-3648、miR-45113、miR-3652、miR- 4640-5p、miR-6871-5p、miR-7845-5p、miR-3138、miR-6884-5p、miR-4653-3 p、miR-636、miR-4652-3p、miR-6823-5p、miR-4502、miR-7113-5p、miR-808 7、miR-71154-3p、miR-51189-5p、miR-1253、miR-5118c-5p、miR-711511-5p、miR- 36144-3p、miR-4727-5p、miR-3682-5p、miR-5090、miR-337-3p、miR-488-5p 、miR-100-5p、miR-4520-3p、miR-373-3p、miR-6499-5p、miR-3909、miR-32- 5p、miR-302a-3p、miR-4686、miR-4659a-3p、miR-4287、miR-1301-5p、miR-5 93-3p、miR-5117a-3p、miR-5117b-3p、miR-1142-3p、miR-11185-2-3p、miR-602、miR-527, miR-518a-5p, miR-4682, miR-28-5p, miR-4252, miR-452-5p, miR -525-5p, miR-3622a-3p, miR-6813-3p, miR-4769-3p, miR-5698, miR-1915 -3p, miR-1343-5p, miR-6861-5p, miR-6781-5p, miR-4508, miR-6743-5p, m iR-6726-5p, miR-4525, miR-4651, miR-6813-5p, miR-5787, miR-1290, miR -6075, miR-4758-5p, miR-4690-5p, miR-762, miR-371a-5p, miR-6765-3p, miR-6784-5p, miR-6778-5p, miR-6875-5p, miR-4534, miR-4721, miR-6756 -5p, miR-615-5p, miR-6727-5p, miR-6887-5p, miR-8063, miR-6880-5p, mi R-6805-3p, miR-4726-5p, miR-4710, miR-7111-5p, miR-3619-3p, miR-679 5-5p, miR-1254, miR-1233-5p, miR-6836-3p, miR-6769a-5p, miR-4532, mi R-365a-5p, miR-1231, miR-1228-5p, miR-4430, miR-296-3p, miR-1237-5p , miR-4466, miR-6789-5p, miR-4632-5p, miR-4745-5p, miR-4665-5p, miR- 6807-5p, miR-7114-5p, miR-516a-5p, miR-769-3p, miR-3692-5p, miR-394 5, a nucleic acid probe capable of specifically binding to one or more polynucleotides selected from the group consisting of miR-4433a-3p, miR-4485-3p, miR-6831-5p, miR-519c-5p, miR-551b-5p, miR-1343-3p, miR-4286, miR-4634, miR-4733-3p, and miR-6086 (excluding a combination of polynucleotides containing miR-4443, miR-4728-5p, and miR-4734), and / or a primer for specifically recognizing and amplifying the polynucleotide;The kit according to claim 1 or 2, further comprising as a detection nucleic acid:

4. The additional detecting nucleic acid is a polynucleotide selected from the group consisting of (a') to (d') below: (a') a polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 1 to 22, 24, 25, 27 to 210, 374, 1315 to 1350, and 1435 to 1448, or a base sequence in which u is t in the base sequence; a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence; a labeled derivative thereof; a modified nucleotide; or a peptide nucleic acid (PNA); or a partial fragment of any of these containing 15 or more consecutive bases; (b') a polynucleotide comprising a base sequence represented by any one of SEQ ID NOs: 1 to 22, 24, 25, 27 to 210, 374, 1315 to 1350, and 1435 to 1448; (c') a polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 1 to 22, 24, 25, 27 to 210, 374, 1315 to 1350, and 1435 to 1448, or a base sequence complementary to the base sequence in which u is t in the base sequence; a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence; a labeled derivative thereof; a modified nucleotide; or a peptide nucleic acid (PNA); or a partial fragment of any of these containing 15 or more consecutive bases; (d') a polynucleotide comprising a base sequence complementary to any one of SEQ ID NOs: 1 to 22, 24, 25, 27 to 210, 374, 1315 to 1350, and 1435 to 1448, or the base sequence in which u is t; The kit according to claim 3, wherein

5. The kit is another dementia marker, miR-1225-3p, miR-3184-5p, miR-665, miR-1247-5p, miR-3656, miR-149-5p, miR-744-5p, miR-345-5p, miR-150-5p, miR-191-3p, miR-651-5p, miR-34a-5p, miR-409-5p, miR-369-5p, miR-1915-5p, miR-204-5p, miR-137, miR-382-5p, miR-517-5p, miR-532-5p, miR-22-5p, miR-1237-3p, miR-1224-3p, miR-625-3p, miR-328-3p, miR-122-5p, miR-202-3p, miR-4781-5p, miR-718, miR-342-3p, miR-26b-3p, miR-140-3p, miR-200a-3p, miR-378a-3p, miR-484, miR-296-5p, miR-205-5p, miR-431-5p, miR-150-3p, miR-423-5p, miR-575, miR-671-5p, miR-939-5p, miR-3665, miR-30d-5p, miR-30b-3p, miR-92a-3p, miR-371b-5p, miR-486-5p, miR-1471, miR-1538, miR-449b-3p, miR-1976, miR-4268, miR-4279, miR-3620-3p, miR-3944-3p, miR-3156-3p, miR-3187-5p, miR-4685-3p, miR-4695-3p, miR-4697-3p, miR-4713-5p, miR-4723-3p, miR-371b-3p, miR-3151-3p, miR-3192-3p, miR-6728-3p, miR-6736-3p, miR-6740-3p, miR-6741-3p, miR-6743-3p, miR-6747-3p, miR-6750-3p, miR-6754-3p, miR-6759-3p, miR-6761-3p, miR-6762-3p, miR-6769a-3q, miR-6776-3p, miR-6778-3p, miR-6779-3p, miR-6786-3p, miR-67Bia-3p, miR-6792-3p, miR-6794-3p, miR-6801-3p,miR-6802-3p、miR-6803-3p、miR-6804-3p、miR-6810-5p、miR-6823-3p、mi R-6825-3p、miR-6829-3p、miR-6833-3p、miR-6834-3p、miR-6780b-3p、miR -6845-3p、miR-6862-3p、miR-6865-3p、miR-6870-3p、miR-6875-3p、miR-6 877-3p、miR-6879-3p、miR-6882-3p、miR-6885-3p、miR-6886-3p、miR-688 7-3p、miR-6890-3p、miR-6893-3p、miR-6894-3p、miR-7106-3p、miR-7109- 3p、miR-7114-3p、miR-7155-5p、miR-7160-5p、miR-615-3p、miR-920、miR- 1825、miR-675-3p、miR-1811910-5p、miR-22278、miR-2682-3p、miR-318222、miR- 31511-5p、miR-31175、miR-4323、miR-4326、miR-4284、miR-3605-3p、miR-36 22b-5p、miR-3646、miR-3158-5p、miR-4722-3p、miR-4728-3p、miR-4747-3 p、miR-4436b-5p、miR-5196-3p、miR-5589-5p、miR-345-3p、miR-642b-5p、 miR-6716-3p、miR-6511b-3p、miR-208a-5p、miR-6726-3p、miR-6744-5p、m iR-6782-3p、miR-6789-3p、miR-6797-3p、miR-6800-3p、miR-6806-5p、miR -6824-3p、miR-6837-5p、miR-6846-3p、miR-6858-3p、miR-6859-3p、miR-6 861-3p、miR-6880-3p、miR-7111-3p、miR-7152-5p、miR-642a-5p、miR-657 、miR-1236-3p、miR-764、miR-4314、miR-3675-3p、miR-5703、miR-3191-5p 、miR-6511a-3p、miR-6809-3p、miR-6815-5p、miR-6857-3p、miR-6878-3p、The kit according to any one of claims 1 to 4, further comprising, as an additional detection nucleic acid, a nucleic acid probe capable of specifically binding to one or more polynucleotides selected from the group consisting of miR-766-3p, miR-1229-3p, miR-1306-5p, miR-210-5p, miR-198, miR-485-3p, miR-668-3p, miR-532-3p, miR-877-3p, miR-1238-3p, miR-3130-5p, miR-4298, miR-4290, miR-3943, miR-346, and miR-767-3p, and / or a primer for specifically recognizing and amplifying the polynucleotide.

6. The additional detection nucleic acid is a polynucleotide selected from the group consisting of (f) to (i) below: (f) a polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 211 to 213, 215 to 373, 375 to 390, 1351 to 1356, and 1449 to 1453, or a base sequence in which u is t in the base sequence; a polynucleotide consisting of a base sequence having 90% or more percent identity to the base sequence; a labeled derivative thereof; a modified nucleotide or peptide nucleic acid (PNA); or a partial fragment containing 15 or more consecutive bases of any of these; (G) a polynucleotide comprising a base sequence represented by any one of SEQ ID NOs: 211 to 213, 215 to 373, 375 to 390, 1351 to 1356, and 1449 to 1453; (h) a polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 211 to 213, 215 to 373, 375 to 390, 1351 to 1356, and 1449 to 1453, or a base sequence complementary to the base sequence in which u is t in the base sequence; a polynucleotide consisting of a base sequence having 90% or more percent identity to the base sequence; a labeled derivative thereof; a modified nucleotide or peptide nucleic acid (PNA); or a partial fragment containing 15 or more consecutive bases of any of these; (I) a polynucleotide comprising a base sequence complementary to any one of SEQ ID NOs: 211 to 213, 215 to 373, 375 to 390, 1351 to 1356, and 1449 to 1453, or the base sequence in which u is t; The kit according to claim 5, wherein

7. A device for detecting dementia, comprising a detection nucleic acid, The device, wherein the detection nucleic acid is a nucleic acid probe capable of specifically binding to each of the polynucleotides of miR-4486, miR-6088, and miR-211-5p, which are dementia markers, and / or a primer for specifically recognizing and amplifying the polynucleotide.

8. The detection nucleic acid A polynucleotide selected from the group consisting of (a) to (d) below: (a) a polynucleotide consisting of the base sequence represented by SEQ ID NO: 23 or the base sequence in which u is replaced with t, a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment of any of these containing 15 or more consecutive bases; (b) a polynucleotide comprising the base sequence represented by SEQ ID NO: 23; (c) a polynucleotide consisting of a base sequence complementary to the base sequence represented by SEQ ID NO: 23 or the base sequence in which u is t, a polynucleotide consisting of a base sequence having 90% or more percent identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment containing 15 or more consecutive bases of any of these; and (d) a polynucleotide comprising a base sequence complementary to the base sequence represented by SEQ ID NO: 23 or the base sequence in which u is replaced with t; A polynucleotide selected from the group consisting of (a1) to (d1) below: (a1) a polynucleotide consisting of the base sequence represented by SEQ ID NO: 26 or the base sequence in which u is replaced with t, a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment of any of these containing 15 or more consecutive bases; (b1) a polynucleotide comprising the base sequence represented by SEQ ID NO: 26; (c1) A polynucleotide consisting of a base sequence complementary to the base sequence represented by SEQ ID NO: 26 or the base sequence in which u is t, a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment containing 15 or more consecutive bases of any of these, and (d1) a polynucleotide comprising a base sequence complementary to the base sequence represented by SEQ ID NO: 26 or the base sequence in which u is t; and A polynucleotide selected from the group consisting of (a2) to (d2) below: (a2) a polynucleotide consisting of the base sequence represented by SEQ ID NO: 214 or the base sequence in which u is t, a polynucleotide consisting of a base sequence having 90% or more percent identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment containing 15 or more consecutive bases of any of these, (b2) a polynucleotide comprising the base sequence represented by SEQ ID NO: 214; (c2) a polynucleotide consisting of a base sequence complementary to the base sequence represented by SEQ ID NO: 214 or the base sequence in which u is t, a polynucleotide consisting of a base sequence having 90% or more percent identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment containing 15 or more consecutive bases of any of these; and (d2) a polynucleotide comprising a base sequence complementary to the base sequence represented by SEQ ID NO: 214 or the base sequence in which u is t; 8. The device of claim 7, wherein:

9. Another dementia marker, miR-4274, miR-4272, miR-4728-5p, miR-4443, miR-4506, miR-6773-5p, miR-4662a-5p, miR-3184-3p, miR-4281, miR-320d, miR-6729-3p, miR-5192, miR-6853-5p, miR-1234-3p, miR-1233-3p, miR-4539, miR-3914, miR-4738-5p, miR-548au-3p, miR-1539, miR-4720-3p, miR-365b-5p, miR-1227-5p, miR-4667-5p, miR-6820-5p, miR-4505, miR-548q, miR-4658, miR-450a-5p, miR-1260b, miR-3677-5p, miR-6777-3p, miR-6826-3p, miR-6832-3p, miR-4725-3p, miR-7161-3p, miR-2277-5p, miR-7110-3p, miR-4312, miR-4461, miR-6766-5p, miR-1266-3p, miR-6729-5p, miR-526b-3p, miR-519e-5p, miR-512-5p, miR-5088-5p, miR-1909-3p, miR-6511a-5p, miR-4734, miR-936, miR-1249-3p, miR-6777-5p, miR-4487, miR-3155a, miR-563, miR-4741, miR-6788-5p, miR-4433b-5p, miR-323a-5p, miR-6811-5p, miR-6721-5p, miR-5004-5p, miR-6509-3p, miR-648, miR-3917, miR-6087, miR-1470, miR-586, miR-3150a-5p, miR-105-3p, miR-7973, miR-1914-5p, miR-4749-3p, miR-15b-5p, miR-1289, miR-4433a-5p, miR-3666, miR-3186-3p, miR-4725-5p, miR-4488, miR-4474-3p, miR-6731-3p, miR-4640-3p, miR-202-5p, miR-6816-5p, miR-638, miR-6821-5p, miR-1247-3p, miR-6765-5pmiR-6800-5p、miR-3928-3p、miR-3940-5p、miR-3960、miR-6775-5p、miR-3 1888、miR-1202、miR-6790-5p、miR-4731-3p、miR-26811-3p、miR-6758-5p、mi R-8072、miR-518d-3p、miR-3606-3p、miR-4800-5p、miR-1292-3p、miR-678 4-3p、miR-4450、miR-6132、miR-4716-5p、miR-6860、miR-1268b、miR-378d、 miR-4701-5p、miR-4329、miR-185-3p、miR-552-3p、miR-1273g-5p、miR-67 69b-3p、miR-520a-3p、miR-4524b-5p、miR-42911、miR-6734-3p、miR-143-5p 、miR-939-3p、miR-6889-3p、miR-6842-3p、miR-451111、miR-43118、miR-4653 -5p、miR-6867-3p、miR-133b、miR-3196、miR-193b-3p、miR-3162-3p、miR-6 8119-3p、miR-1908-3p、miR-6786-5p、miR-3648、miR-45113、miR-3652、miR- 4640-5p、miR-6871-5p、miR-7845-5p、miR-3138、miR-6884-5p、miR-4653-3 p、miR-636、miR-4652-3p、miR-6823-5p、miR-4502、miR-7113-5p、miR-808 7、miR-71154-3p、miR-51189-5p、miR-1253、miR-5118c-5p、miR-711511-5p、miR- 36144-3p、miR-4727-5p、miR-3682-5p、miR-5090、miR-337-3p、miR-488-5p 、miR-100-5p、miR-4520-3p、miR-373-3p、miR-6499-5p、miR-3909、miR-32- 5p、miR-302a-3p、miR-4686、miR-4659a-3p、miR-4287、miR-1301-5p、miR-5 93-3p、miR-5117a-3p、miR-5117b-3p、miR-1142-3p、miR-11185-2-3p、miR-602、miR-527, miR-518a-5p, miR-4682, miR-28-5p, miR-4252, miR-452-5p, mi R-525-5p, miR-3622a-3p, miR-6813-3p, miR-4769-3p, miR-5698, miR-191 5-3p, miR-1343-5p, miR-6861-5p, miR-6781-5p, miR-4508, miR-6743-5p, miR-6726-5p, miR-4525, miR-4651, miR-6813-5p, miR-5787, miR-1290, mi R-6075, miR-4758-5p, miR-4690-5p, miR-762, miR-371a-5p, miR-6765-3p , miR-6784-5p, miR-6778-5p, miR-6875-5p, miR-4534, miR-4721, miR-675 6-5p, miR-615-5p, miR-6727-5p, miR-6887-5p, miR-8063, miR-6880-5p, m iR-6805-3p, miR-4726-5p, miR-4710, miR-7111-5p, miR-3619-3p, miR-67 95-5p, miR-1254, miR-1233-5p, miR-6836-3p, miR-6769a-5p, miR-4532, m iR-365a-5p, miR-1231, miR-1228-5p, miR-4430, miR-296-3p, miR-1237-5 p, miR-4466, miR-6789-5p, miR-4632-5p, miR-4745-5p, miR-4665-5p, miR -6807-5p, miR-7114-5p, miR-516a-5p, miR-769-3p, miR-3692-5p, miR-39 45, miR-4433a-3p, miR-4485-3p, miR-6831-5p, miR-519c-5p, miR-551b-5p, miR-1343-3p, miR-4286, miR-4634, miR-4733-3p, and miR-6086 (excluding a combination of polynucleotides containing miR-4443, miR-4728-5p, and miR-4734), and / or a primer for specifically recognizing and amplifying the polynucleotide,The device according to claim 7 or 8, comprising as an additional detector nucleic acid.

10. The additional detecting nucleic acid is a polynucleotide selected from the group consisting of (a') to (d') below: (a') a polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 1 to 22, 24, 25, 27 to 210, 374, 1315 to 1350, and 1435 to 1448, or a base sequence in which u is t in the base sequence; a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence; a labeled derivative thereof; a modified nucleotide; or a peptide nucleic acid (PNA); or a partial fragment of any of these containing 15 or more consecutive bases; (b') a polynucleotide comprising a base sequence represented by any one of SEQ ID NOs: 1 to 22, 24, 25, 27 to 210, 374, 1315 to 1350, and 1435 to 1448; (c') a polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 1 to 22, 24, 25, 27 to 210, 374, 1315 to 1350, and 1435 to 1448, or a base sequence complementary to the base sequence in which u is t in the base sequence; a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence; a labeled derivative thereof; a modified nucleotide; or a peptide nucleic acid (PNA); or a partial fragment of any of these containing 15 or more consecutive bases; (d') a polynucleotide comprising a base sequence complementary to any one of SEQ ID NOs: 1 to 22, 24, 25, 27 to 210, 374, 1315 to 1350, and 1435 to 1448, or the base sequence in which u is t; 10. The device of claim 9, wherein:

11. The device is another dementia marker, miR-1225-3p, miR-3184-5p, miR-665, miR-1247-5p, miR-3656, miR-149-5p, miR-744-5p, miR-345-5p, miR-150-5p, miR-191-3p, miR-651-5p, miR-34a-5p, miR-409-5p, miR-369-5p, miR-1915-5p, miR-204-5p, miR-137, miR-382-5p, miR-517-5p, miR-532-5p, miR-22-5p, miR-1237-3p, miR-1224-3p, miR-625-3p, miR-328-3p, miR-122-5p, miR-202-3p, miR-4781-5p, miR-718, miR-342-3p, miR-26b-3p, miR-140-3p, miR-200a-3p, miR-378a-3p, miR-484, miR-296-5p, miR-205-5p, miR-431-5p, miR-miR-6802-3p、miR-6803-3p、miR-6804-3p、miR-6810-5p、miR-6823-3p、mi R-6825-3p、miR-6829-3p、miR-6833-3p、miR-6834-3p、miR-6780b-3p、miR -6845-3p、miR-6862-3p、miR-6865-3p、miR-6870-3p、miR-6875-3p、miR-6 877-3p、miR-6879-3p、miR-6882-3p、miR-6885-3p、miR-6886-3p、miR-688 7-3p、miR-6890-3p、miR-6893-3p、miR-6894-3p、miR-7106-3p、miR-7109- 3p、miR-7114-3p、miR-7155-5p、miR-7160-5p、miR-615-3p、miR-920、miR- 1825、miR-675-3p、miR-1811910-5p、miR-22278、miR-2682-3p、miR-318222、miR- 31511-5p、miR-31175、miR-4323、miR-4326、miR-4284、miR-3605-3p、miR-36 22b-5p、miR-3646、miR-3158-5p、miR-4722-3p、miR-4728-3p、miR-4747-3 p、miR-4436b-5p、miR-5196-3p、miR-5589-5p、miR-345-3p、miR-642b-5p、 miR-6716-3p、miR-6511b-3p、miR-208a-5p、miR-6726-3p、miR-6744-5p、m iR-6782-3p、miR-6789-3p、miR-6797-3p、miR-6800-3p、miR-6806-5p、miR -6824-3p、miR-6837-5p、miR-6846-3p、miR-6858-3p、miR-6859-3p、miR-6 861-3p、miR-6880-3p、miR-7111-3p、miR-7152-5p、miR-642a-5p、miR-657 、miR-1236-3p、miR-764、miR-4314、miR-3675-3p、miR-5703、miR-3191-5p 、miR-6511a-3p、miR-6809-3p、miR-6815-5p、miR-6857-3p、miR-6878-3p、The device according to any one of claims 7 to 10, further comprising, as an additional detection nucleic acid, a nucleic acid probe capable of specifically binding to one or more polynucleotides selected from the group consisting of miR-766-3p, miR-1229-3p, miR-1306-5p, miR-210-5p, miR-198, miR-485-3p, miR-668-3p, miR-532-3p, miR-877-3p, miR-1238-3p, miR-3130-5p, miR-4298, miR-4290, miR-3943, miR-346, and miR-767-3p, and / or a primer for specifically recognizing and amplifying the polynucleotide.

12. The additional detection nucleic acid is a polynucleotide selected from the group consisting of (f) to (i) below: (f) a polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 211 to 213, 215 to 373, 375 to 390, 1351 to 1356, and 1449 to 1453, or a base sequence in which u is t in the base sequence; a polynucleotide consisting of a base sequence having 90% or more percent identity to the base sequence; a labeled derivative thereof; a modified nucleotide; or a peptide nucleic acid (PNA). or a partial fragment containing 15 or more consecutive bases of any of these, (G) a polynucleotide comprising a base sequence represented by any one of SEQ ID NOs: 211 to 213, 215 to 373, 375 to 390, 1351 to 1356, and 1449 to 1453; (h) a polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 211 to 213, 215 to 373, 375 to 390, 1351 to 1356, and 1449 to 1453, or a base sequence complementary to the base sequence in which u is t in the base sequence; a polynucleotide consisting of a base sequence having 90% or more percent identity to the base sequence; a labeled derivative thereof; a modified nucleotide or peptide nucleic acid (PNA); or a partial fragment containing 15 or more consecutive bases of any of these; (I) a polynucleotide comprising a base sequence complementary to any one of SEQ ID NOs: 211 to 213, 215 to 373, 375 to 390, 1351 to 1356, and 1449 to 1453, or the base sequence in which u is t; 12. The device of claim 11, wherein:

13. The device according to any one of claims 7 to 12, which is a device for measurement by hybridization technology.

14. The device of claim 13 , wherein the hybridization technology is a nucleic acid array technology.

15. A method for assisting in the detection of dementia, comprising measuring the expression levels of dementia markers miR-4486, miR-6088, and miR-211-5p in a specimen from a subject, and using the measured expression levels to evaluate in vitro whether or not the subject is suffering from dementia.

16. The method of claim 15, comprising substituting the expression levels of miR-4486, miR-6088 and miR-211-5p in a sample derived from a subject known to have dementia into a discriminant that is prepared using the gene expression levels of a sample derived from the subject known to have dementia and the gene expression levels of a sample derived from a non-demented subject as teacher samples and that is capable of discriminating between dementia and non-dementia, thereby assessing dementia or non-dementia.

17. The expression level of miR-4486 is measured using a nucleic acid probe capable of specifically binding to miR-4486 and / or a primer for specifically recognizing and amplifying miR-4486, and the nucleic acid probe capable of specifically binding to miR-4486 and / or the primer for specifically recognizing and amplifying miR-4486 is a polynucleotide selected from the group consisting of the following (a) to (d): (a) a polynucleotide consisting of the base sequence represented by SEQ ID NO: 23, or the base sequence in which u is replaced with t, a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence, a labeled derivative thereof, a modified nucleotide, or a peptide nucleic acid (PNA), or a partial fragment of any of these containing 15 or more consecutive bases; (b) a polynucleotide comprising the base sequence represented by SEQ ID NO: 23; (c) a polynucleotide consisting of a base sequence complementary to the base sequence represented by SEQ ID NO: 23, or the base sequence in which u is t in the base sequence, a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment containing 15 or more consecutive bases of any of these; and (d) a polynucleotide comprising a base sequence complementary to the base sequence represented by SEQ ID NO: 23, or the base sequence in which u is t; and The expression level of miR-6088 is measured using a nucleic acid probe capable of specifically binding to miR-6088 and / or a primer for specifically recognizing and amplifying miR-6088, and the nucleic acid probe capable of specifically binding to miR-6088 and / or the primer for specifically recognizing and amplifying miR-6088 is a polynucleotide selected from the group consisting of the following (a1) to (d1): (a1) a polynucleotide consisting of the base sequence represented by SEQ ID NO: 26, or the base sequence in which u is t in the base sequence, a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment of any of these containing 15 or more consecutive bases; (b1) a polynucleotide comprising the base sequence represented by SEQ ID NO: 26; (c1) A polynucleotide consisting of a base sequence complementary to the base sequence represented by SEQ ID NO: 26, or the base sequence in which u is t in the base sequence, a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment containing 15 or more consecutive bases of any of these, and (d1) a polynucleotide comprising a base sequence complementary to the base sequence represented by SEQ ID NO: 26, or the base sequence in which u is t; and The expression level of the miR-211-5p is measured using a nucleic acid probe capable of specifically binding to the miR-211-5p and / or a primer for specifically recognizing and amplifying the miR-211-5p, and the nucleic acid probe capable of specifically binding to the miR-211-5p and / or the primer for specifically recognizing and amplifying the miR-211-5p is a polynucleotide selected from the group consisting of the following (a2) to (d2): (a2) a polynucleotide consisting of the base sequence represented by SEQ ID NO: 214 or the base sequence in which u is t, a polynucleotide consisting of a base sequence having 90% or more percent identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment containing 15 or more consecutive bases of any of these, (b2) a polynucleotide comprising the base sequence represented by SEQ ID NO: 214; (c2) a polynucleotide consisting of a base sequence complementary to the base sequence represented by SEQ ID NO: 214 or the base sequence in which u is t, a polynucleotide consisting of a base sequence having 90% or more percent identity to the base sequence, a labeled derivative thereof, a modified nucleotide or peptide nucleic acid (PNA), or a partial fragment containing 15 or more consecutive bases of any of these; and (d2) a polynucleotide comprising a base sequence complementary to the base sequence represented by SEQ ID NO: 214 or the base sequence in which u is t; The method according to claim 15 or 16, wherein

18. Another dementia marker, miR-4274, miR-4272, miR-4728-5p, miR-4443, miR-4506, miR-6773-5p, miR-4662a-5p, miR-3184-3p, miR-4281, miR-320d, miR-6729-3p, miR-5192, miR-6853-5p, miR-1234-3p, miR-1233-3p, miR-4539, miR-3914, miR-4738-5p, miR-548au-3p, miR-1539, miR-4720-3p, miR-365b-5p, miR-1227-5p, miR-4667-5p, miR-6820-5p, miR-4505, miR-548q, miR-4658, miR-450a-5p, miR-1260b, miR-3677-5p, miR-6777-3p, miR-6826-3p, miR-6832-3p, miR-4725-3p, miR-7161-3p, miR-2277-5p, miR-7110-3p, miR-4312, miR-4461, miR-6766-5p, miR-1266-3p, miR-6729-5p, miR-526b-3p, miR-519e-5p, miR-512-5p, miR-5088-5p, miR-1909-3p, miR-6511a-5p, miR-4734, miR-936, miR-1249-3p, miR-6777-5p, miR-4487, miR-3155a, miR-563, miR-4741, miR-6788-5p, miR-4433b-5p, miR-323a-5p, miR-6811-5p, miR-6721-5p, miR-5004-5p, miR-6509-3p, miR-648, miR-3917, miR-6087, miR-1470, miR-586, miR-3150a-5p, miR-105-3p, miR-7973, miR-1914-5p, miR-4749-3p, miR-15b-5p, miR-1289, miR-4433a-5p, miR-3666, miR-3186-3p, miR-4725-5p, miR-4488, miR-4474-3p, miR-6731-3p, miR-4640-3p, miR-202-5p, miR-6816-5p, miR-638, miR-6821-5p, miR-1247-3p, miR-6765-5pmiR-6800-5p、miR-3928-3p、miR-3940-5p、miR-3960、miR-6775-5p、miR-3 1888、miR-1202、miR-6790-5p、miR-4731-3p、miR-26811-3p、miR-6758-5p、mi R-8072、miR-518d-3p、miR-3606-3p、miR-4800-5p、miR-1292-3p、miR-678 4-3p、miR-4450、miR-6132、miR-4716-5p、miR-6860、miR-1268b、miR-378d、 miR-4701-5p、miR-4329、miR-185-3p、miR-552-3p、miR-1273g-5p、miR-67 69b-3p、miR-520a-3p、miR-4524b-5p、miR-42911、miR-6734-3p、miR-143-5p 、miR-939-3p、miR-6889-3p、miR-6842-3p、miR-451111、miR-43118、miR-4653 -5p、miR-6867-3p、miR-133b、miR-3196、miR-193b-3p、miR-3162-3p、miR-6 8119-3p、miR-1908-3p、miR-6786-5p、miR-3648、miR-45113、miR-3652、miR- 4640-5p、miR-6871-5p、miR-7845-5p、miR-3138、miR-6884-5p、miR-4653-3 p、miR-636、miR-4652-3p、miR-6823-5p、miR-4502、miR-7113-5p、miR-808 7、miR-71154-3p、miR-51189-5p、miR-1253、miR-5118c-5p、miR-711511-5p、miR- 36144-3p、miR-4727-5p、miR-3682-5p、miR-5090、miR-337-3p、miR-488-5p 、miR-100-5p、miR-4520-3p、miR-373-3p、miR-6499-5p、miR-3909、miR-32- 5p、miR-302a-3p、miR-4686、miR-4659a-3p、miR-4287、miR-1301-5p、miR-5 93-3p、miR-5117a-3p、miR-5117b-3p、miR-1142-3p、miR-11185-2-3p、miR-602、miR-527, miR-518a-5p, miR-4682, miR-28-5p, miR-4252, miR-452-5p, mi R-525-5p, miR-3622a-3p, miR-6813-3p, miR-4769-3p, miR-5698, miR-19 15-3p, miR-1343-5p, miR-6861-5p, miR-6781-5p, miR-4508, miR-6743-5 p, miR-6726-5p, miR-4525, miR-4651, miR-6813-5p, miR-5787, miR-1290, miR-6075, miR-4758-5p, miR-4690-5p, miR-762, miR-371a-5p, miR-6765 -3p, miR-6784-5p, miR-6778-5p, miR-6875-5p, miR-4534, miR-4721, miR -6756-5p, miR-615-5p, miR-6727-5p, miR-6887-5p, miR-8063, miR-6880 -5p, miR-6805-3p, miR-4726-5p, miR-4710, miR-7111-5p, miR-3619-3p, m iR-6795-5p, miR-1254, miR-1233-5p, miR-6836-3p, miR-6769a-5p, miR- 4532, miR-365a-5p, miR-1231, miR-1228-5p, miR-4430, miR-296-3p, miR -1237-5p, miR-4466, miR-6789-5p, miR-4632-5p, miR-4745-5p, miR-466 5-5p, miR-6807-5p, miR-7114-5p, miR-516a-5p, miR-769-3p, miR-3692-5 The method according to any one of claims 15 to 17, comprising measuring the expression level of one or more additional polynucleotides selected from the group consisting of miR-4443, miR-4728-5p, miR-3945, miR-4433a-3p, miR-4485-3p, miR-6831-5p, miR-519c-5p, miR-551b-5p, miR-1343-3p, miR-4286, miR-4634, miR-4733-3p, and miR-6086 (excluding a combination of polynucleotides comprising miR-4443, miR-4728-5p, and miR-4734).

19. The expression level of the polynucleotide is measured using a nucleic acid probe capable of specifically binding to the additional polynucleotide and / or a primer for specifically recognizing and amplifying the polynucleotide, and the nucleic acid probe capable of specifically binding to the additional polynucleotide and / or the primer for specifically recognizing and amplifying the polynucleotide is a polynucleotide selected from the group consisting of the following (a') to (d'): (a') a polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 1 to 22, 24, 25, 27 to 210, 374, 1315 to 1350, and 1435 to 1448, or a base sequence in which u is t in the base sequence; a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence; a labeled derivative thereof; a modified nucleotide; or a peptide nucleic acid (PNA); or a partial fragment of any of these containing 15 or more consecutive bases; (b') a polynucleotide comprising a base sequence represented by any one of SEQ ID NOs: 1 to 22, 24, 25, 27 to 210, 374, 1315 to 1350, and 1435 to 1448; (c') a polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 1 to 22, 24, 25, 27 to 210, 374, 1315 to 1350, and 1435 to 1448, or a base sequence complementary to the base sequence in which u is t in the base sequence; a polynucleotide consisting of a base sequence having 90% or more identity to the base sequence; a labeled derivative thereof; a modified nucleotide; or a peptide nucleic acid (PNA); or a partial fragment of any of these containing 15 or more consecutive bases; (d') a polynucleotide comprising a base sequence complementary to any one of SEQ ID NOs: 1 to 22, 24, 25, 27 to 210, 374, 1315 to 1350, and 1435 to 1448, or the base sequence in which u is t; 19. The method of claim 18, wherein:

20. Other dementia markers, miR-1225-3p, miR-3184-5p, miR-665, miR-1247-5p, miR-3656, miR-149-5p, miR-744-5p, miR-345-5p, miR-150-5p, miR-191-3p, miR-651-5p, miR-34a-5p, miR-409-5p, miR-369-5p, miR-1915-5p, miR-204-5p, miR-137, miR-382-5p, miR-517-5p, miR-532-5p, miR-22-5p, miR-1237-3p, miR-1224-3p, miR-625-3p, miR-328-3p, miR-122-5p, miR-202-3p, miR-4781-5p, miR-718, miR-342-3p, miR-26b-3p, miR-140-3p, miR-200a-3p, miR-378a-3p, miR-484, miR-296-5p, miR-205-5p, miR-431-5p, miR-150-3p, miR-423-5p, miR-575, miR-671-5p, miR-939-5p, miR-3665, miR-30d-5p, miR-30b-3p, miR-92a-3p, miR-371b-5p, miR-486-5p, miR-1471, miR-1538, miR-449b-3p, miR-1976, miR-4268, miR-4279, miR-3620-3p, miR-3944-3p, miR-3156-3p, miR-3187-5p, miR-4685-3p, miR-4695-3p, miR-4697-3p, miR-4713-5p, miR-4723-3p, miR-371b-3p, miR-3151-3p, miR-3192-3p, miR-6728-3p, miR-6736-3p, miR-6740-3p, miR-6741-3p, miR-6743-3p, miR-6747-3p, miR-6750-3p, miR-6754-3p, miR-6759-3p, miR-6761-3p, miR-6762-3p, miR-6769a-3p, miR-6776-3p, miR-6778-3p, miR-6779-3p, miR-6786-3p, miR-6787-3p, miR-6792-3p, miR-6794-3p, miR-6801-3p, miR-6802-3pmiR-6803-3p、miR-6804-3p、miR-6810-5p、miR-6823-3p、miR-6823-3p、m iR-6829-3p、miR-6833-3p、miR-6834-3p、miR-6780b-3p、miR-6-6845-3p、mi R-6862-3p、miR-6865-3p、miR-6870-3p、miR-6875-3p、miR-6877-3p、miR- 6879-3p、miR-6882-3p、miR-6885-3p、miR-6886-3p、miR-6887-3p、miR-68 90-3p、miR-6893-3p、miR-6894-3p、miR-7106-3p、miR-7109-3p、miR-7114 -3p、miR-7155-5p、miR-7160-5p、miR-615-3p、miR-920、miR-1825、miR-67 5-3p、miR-1910-5p、miR-2278、miR-2682-3p、miR-3122、miR-3151-5p、miR -31175、miR-4323、miR-4326、miR-4284、miR-3605-3p、miR-3622b-5p、miR- 3646、miR-3158-5p、miR-4722-3p、miR-4728-3p、miR-4747-3p、miR-4436b -5p、miR-51196-3p、miR-5589-5p、miR-345-3p、miR-642b-5p、miR-6716-3p 、miR-65111b-3p、miR-208a-5p、miR-6726-3p、miR-6744-5p、miR-6782-3p、 miR-6789-3p、miR-6797-3p、miR-6800-3p、miR-6806-5p、miR-6824-3p、mi R-68337-5p、miR-6846-3p、miR-6858-3p、miR-6859-3p、miR-6859-3p、miR- 88880-33p、miR-71111-3p、miR-7152-5p、miR-642a-5p、miR-657、miR-1236-3 p、miR-764、miR-4314、miR-3675-3p、miR-5703、miR-3191-5p、miR-6511a- 3p、miR-6809-3p、miR-6815-5p、miR-6857-3p、miR-6878-3p、miR-766-3p、The method according to any one of claims 15 to 19, further comprising measuring the expression level of one or more additional polynucleotides selected from the group consisting of miR-1229-3p, miR-1306-5p, miR-210-5p, miR-198, miR-485-3p, miR-668-3p, miR-532-3p, miR-877-3p, miR-1238-3p, miR-3130-5p, miR-4298, miR-4290, miR-3943, miR-346, and miR-767-3p.

21. The expression level of the polynucleotide is measured using a nucleic acid probe capable of specifically binding to the additional polynucleotide and / or a primer for specifically recognizing and amplifying the polynucleotide, and the nucleic acid probe capable of specifically binding to the additional polynucleotide and / or the primer for specifically recognizing and amplifying the polynucleotide is a polynucleotide selected from the group consisting of the following (f) to (i): (f) a polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 211 to 213, 215 to 373, 375 to 390, 1351 to 1356, and 1449 to 1453, or a base sequence in which u is t in the base sequence; a polynucleotide consisting of a base sequence having 90% or more percent identity to the base sequence; a labeled derivative thereof; a modified nucleotide or peptide nucleic acid (PNA); or a partial fragment containing 15 or more consecutive bases of any of these; (G) a polynucleotide comprising a base sequence represented by any one of SEQ ID NOs: 211 to 213, 215 to 373, 375 to 390, 1351 to 1356, and 1449 to 1453; (h) a polynucleotide consisting of a base sequence represented by any one of SEQ ID NOs: 211 to 213, 215 to 373, 375 to 390, 1351 to 1356, and 1449 to 1453, or a base sequence complementary to the base sequence in which u is t in the base sequence; a polynucleotide consisting of a base sequence having 90% or more percent identity to the base sequence; a labeled derivative thereof; a modified nucleotide or peptide nucleic acid (PNA); or a partial fragment containing 15 or more consecutive bases of any of these; (I) a polynucleotide comprising a base sequence complementary to any one of SEQ ID NOs: 211 to 213, 215 to 373, 375 to 390, 1351 to 1356, and 1449 to 1453, or the base sequence in which u is t; 21. The method of claim 20, wherein:

22. The method of any one of claims 15 to 21, wherein the subject is a human.

23. The method according to any one of claims 15 to 22, wherein the sample is blood, serum, or plasma.

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