Solid cleaning preparation

Abstract

To provide a solid cleaning preparation.SOLUTION: A solid cleaning preparation for cleaning an intraoral appliance such as a denture or an orthodontic retainer, the solid cleaning preparation containing (A) at least one selected from the group consisting of a dichloroisocyanurate salt, a quaternary ammonium salt, isopropylmethylphenol, a fluoride, thymol, hinokitiol, cetylpyridinium chloride, benzethonium chloride, chlorhexidine acetate, chlorhexidine gluconate, sodium monofluorophosphate, triclosan, lysozyme chloride, and chlorhexidine hydrochloride, (B) an oxygen-based bleaching agent, (C) a foaming agent, and (D) at least one selected from the group consisting of calcium silicate, dextrin, lactose, starch, gum arabic, gelatin, casein, and talc, wherein an amount of the component (D) is 0.2 pt.mass or more and 5 pts.mass or less with respect to 1 pt.mass of the component (A).SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a solid preparation for cleaning, more particularly to a solid preparation for cleaning oral appliances including dentures, orthodontic retainers, sports mouthpieces, and containers for these appliances. [Background technology]

[0002] Oral care is important for improving quality of life and is also useful for preventing systemic diseases such as cardiovascular disease and diabetes, which are thought to be related to periodontal disease.

[0003] For those who wear dentures or removable retainers after orthodontic treatment, keeping dentures and appliances clean contributes to maintaining oral hygiene and overall health. Keeping dentures and appliances in a dirty state can have a negative impact on the remaining teeth and periodontal tissues that come into contact with the appliances, leading to dental caries and periodontal disease.

[0004] Stains on dentures and retainers include food residue, denture pellicle (derived from saliva), denture plaque, tartar deposits, discoloration, etc. In response to this, denture care compositions such as agents to prevent adhesion of food residues (Patent Document 1) and cleansers that act on biofilms have been proposed (Patent Document 2). [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Laid-Open No. 2018-104345 [Patent Document 2] Patent Publication No. 2021-104937 Summary of the Invention [Problem to be solved by the invention]

[0006] When providing a detergent as a tablet, a typical manufacturing method involves mixing raw materials and then performing a tableting process. However, depending on the physical properties or amounts of the raw materials (such as sterilizing and disinfecting agents) to be blended, the raw material mixture may be viscous or soft. When the mixture is viscous or soft, the mixture adheres to the manufacturing equipment during tableting, making it physically difficult to tablet the mixture. Therefore, depending on the physical properties of the raw material mixture, this may pose a barrier to formulating the detergent as a tablet.

[0007] Although there are detergents that remove or prevent stains from adhering to dentures and retainers, it cannot be said that there have been sufficient proposals for detergents that act effectively on bacterial flora, reduce tableting problems during tablet production, and have excellent dispersibility during use.

[0008] An object of the present invention is to provide a solid preparation for cleansing which has excellent disinfecting action on intraoral instruments, excellent tableting properties during tablet production, and excellent dispersibility during use. [Means for solving the problem]

[0009] As a result of extensive research to solve this problem, the inventors discovered that by incorporating a specific bactericidal component and at least one selected from the group consisting of calcium silicate, dextrin, lactose, starch, gum arabic, gelatin, casein, and talc into an effervescent solid formulation, it is possible to prepare a cleanser that exhibits excellent tableting properties and bactericidal effect during tablet production, while also having good dispersibility and safety suitable for cleaning instruments worn in the oral cavity, and thus completed the present invention.

[0010] That is, the present invention provides the following solid preparations for cleaning. Section 1. A solid preparation for cleaning oral appliances, comprising: (A) at least one selected from the group consisting of dichloroisocyanurate, a quaternary ammonium salt, isopropylmethylphenol, fluoride, thymol, hinokitiol, cetylpyridinium chloride, benzethonium chloride, chlorhexidine acetate, chlorhexidine gluconate, sodium monofluorophosphate, triclosan, lysozyme chloride, and chlorhexidine hydrochloride; (B) an oxygen bleach; (C) a foaming agent; and (D) at least one selected from the group consisting of calcium silicate, dextrin, lactose, starch, gum arabic, gelatin, casein, and talc; wherein the amount of the (D) component is 0.2 parts by mass or more and 5 parts by mass or less per part by mass of the (A) component. Section 2. Item 1. The solid preparation for cleaning according to Item 1, which is a tablet. Section 3. Item 3. The solid preparation for cleansing according to Item 1 or 2, wherein the component (A) is at least one selected from the group consisting of quaternary ammonium salts, isopropylmethylphenol, and cetylpyridinium chloride. Section 4. Item 4. The solid preparation for cleaning according to any one of Items 1 to 3, wherein the component (B) is at least one selected from the group consisting of hydrogen persulfates, persulfates, percarbonates, and perborates. Section 5. The component (C) is a carbonate or hydrogen carbonate, and succinic acid, sulfamic acid, or citric acid Item 5. The solid preparation for cleansing according to any one of Items 1 to 4, which is a combination of Section 6. A method for improving the dispersibility of a solid detergent preparation by incorporating (A) at least one selected from the group consisting of dichloroisocyanurate, a quaternary ammonium salt, isopropylmethylphenol, fluoride, thymol, hinokitiol, cetylpyridinium chloride, benzethonium chloride, chlorhexidine acetate, chlorhexidine gluconate, sodium monofluorophosphate, triclosan, lysozyme chloride, and chlorhexidine hydrochloride, (B) an oxygen bleach, (C) a foaming agent, and (D) at least one selected from the group consisting of calcium silicate, dextrin, lactose, starch, gum arabic, gelatin, casein, and talc, and adjusting the amount of component (D) to be 0.2 parts by mass or more and 5 parts by mass or less per part by mass of component (A). [Effects of the Invention]

[0011] According to the present invention, it is possible to provide a solid preparation for cleaning oral cavity-worn instruments, which has good dispersibility during use, and which has both bactericidal effect and safety. DETAILED DESCRIPTION OF THE INVENTION

[0012] In this specification, the salt may be an alkali metal salt such as a lithium salt, a sodium salt, or a potassium salt; an alkaline earth metal salt such as a barium salt; an ammonium salt; or a hydrate thereof.

[0013] In this specification, examples of bacteria that can be disinfected, sterilized, or removed include, but are not limited to, Candida albicans (a fungus that normally resides in the oral cavity), Streptococcus mutans (a gram-positive cocci that is one of the bacteria that cause dental caries), and Porphyromonas gingivalis (a gram-negative bacillus that is involved in periodontal disease).

[0014] [Solid preparation for cleaning] The solid cleansing preparation of the present invention contains (A) at least one selected from the group consisting of dichloroisocyanurate, quaternary ammonium salt, isopropylmethylphenol, fluoride, thymol, hinokitiol, and chlorhexidine hydrochloride, (B) an oxygen-based bleaching agent, (C) a foaming agent, and (D) at least one selected from the group consisting of calcium silicate, dextrin, lactose, starch, gum arabic, gelatin, casein, and talc, and is intended for cleaning oral appliances such as dentures or orthodontic retainers.

[0015] (Component (A)) The solid preparation for cleansing of the present invention contains (A) at least one selected from the group consisting of dichloroisocyanurate, quaternary ammonium salt, isopropylmethylphenol, fluoride, thymol, hinokitiol, cetylpyridinium chloride, benzethonium chloride, chlorhexidine acetate, chlorhexidine gluconate, sodium monofluorophosphate, triclosan, lysozyme chloride, and chlorhexidine hydrochloride. Examples of the quaternary ammonium salt include cetylpyridinium chloride, benzalkonium chloride, and benzethonium chloride. Two or more of these may be used in combination as component (A). Although not limited thereto, quaternary ammonium salts, isopropylmethylphenol, or cetylpyridinium chloride are preferred, with dichloroisocyanurate, cetylpyridinium chloride, benzethonium chloride, or benzalkonium chloride being more preferred.

[0016] It is preferable that the component (A) be mixed in advance with an aqueous solvent and dissolved or dispersed therein.

[0017] The content of component (A) relative to the total amount of the solid cleaning preparation of the present invention may vary depending on the mass per unit of the solid cleaning preparation. From the viewpoint of achieving the effects of the present invention, however, it is preferably from 0.1% by mass to 20% by mass, more preferably from 0.2% by mass to 10% by mass, even more preferably from 0.3% by mass to 8% by mass, even more preferably from 0.5% by mass to 7.5% by mass, and most preferably from 1% by mass to 5% by mass.

[0018] The aqueous solvent to be mixed with component (A) is not particularly limited as long as it is a liquid that dissolves or disperses component (A), but it can be at least one selected from the group consisting of water, ethanol, isopropanol, and polyhydric alcohols. The amount of aqueous solvent is preferably about 0.1 to 5 parts by mass, and more preferably about 0.5 to 4 parts by mass, per part by mass of component (A). This can improve the dispersibility of the components when using the solid preparation.

[0019] The solid preparation for cleansing of the present invention is preferably dissolved in water for use, and the content of component (A) during use is preferably 0.001 w / v% or more and 1 w / v% or less, more preferably 0.01 w / v% or more and 0.5 w / v% or less, and even more preferably 0.1 w / v% or more and 0.2 w / v% or less, from the viewpoint of exerting the effects of the present invention.

[0020] ((B) Oxygen bleach) The solid preparation for cleaning of the present invention contains an oxygen bleaching agent, such as hydrogen persulfate, persulfate, percarbonate, or perborate.

[0021] Examples of hydrogen persulfates include sodium hydrogen persulfate, potassium hydrogen persulfate, lithium hydrogen persulfate, barium hydrogen persulfate, potassium monohydrogen persulfate double salt, and ammonium hydrogen persulfate.

[0022] Examples of persulfates include sodium persulfate, potassium persulfate, and ammonium persulfate.

[0023] Examples of perborates include sodium perborate, potassium perborate, ammonium perborate, and sodium perborate monohydrate.

[0024] Examples of percarbonates include sodium percarbonate, potassium percarbonate, and ammonium percarbonate.

[0025] As the oxygen bleaching agent, at least one of these may be used, or two or more of them may be used in combination. As the oxygen bleaching agent, alkali metal salts of hydrogen persulfate or double salts of potassium hydrogen persulfate, potassium hydrogen sulfate, and potassium sulfate are preferred.

[0026] The content of component (B) relative to the total amount of the solid cleaning preparation of the present invention may vary depending on the mass per unit of the solid cleaning preparation. From the viewpoint of achieving the effects of the present invention, however, it is preferably from 2% by mass to 50% by mass, more preferably from 3% by mass to 45% by mass, and even more preferably from 4% by mass to 40% by mass.

[0027] The solid preparation for cleaning of the present invention is preferably dissolved in water for use, and the content of component (B) during use is preferably 0.006 w / v% or more and 7 w / v% or less, more preferably 0.02 w / v% or more and 3 w / v% or less, and even more preferably 0.025 w / v% or more and 1.3 w / v% or less, from the viewpoint of exerting the effects of the present invention.

[0028] In the solid preparation for cleansing of the present invention, the ratio of component (B) to component (A) is preferably 0.1 to 500 parts by mass, more preferably 0.3 to 225 parts by mass, and even more preferably 0.5 to 133 parts by mass of component (B) per 1 part by mass of component (A).

[0029] ((C) Foaming Agent) The solid detergent formulation of the present invention contains a foaming agent, such as a combination of a carbonate and / or bicarbonate with an acid.

[0030] Examples of carbonates and / or bicarbonates include sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, and sodium sesquicarbonate. At least one of these may be used, or two or more may be used in combination. As the carbonate and / or bicarbonate, sodium carbonate or sodium bicarbonate is preferred.

[0031] Examples of acids include organic acids and phosphoric acids, and more specifically, citric acid, succinic acid, sulfamic acid, malic acid, gluconic acid, tartaric acid, maleic acid, sorbic acid, phytic acid, and phosphoric acid. At least one of these may be used, or two or more may be used in combination. The acid is not limited to, but is preferably, for example, citric acid, succinic acid, or sulfamic acid.

[0032] The ratio of carbonate and / or bicarbonate to acid is not particularly limited, but is preferably 0.3 parts by mass or more and 4 parts by mass or less of acid per 1 part by mass of carbonate and / or bicarbonate, more preferably 0.4 parts by mass or more and 3.5 parts by mass or less, and even more preferably 0.5 parts by mass or more and 3 parts by mass or less.

[0033] In order to achieve the effects of the present invention, the content of the foaming agent relative to the total amount of the solid preparation for cleaning of the present invention is preferably 30% by mass or more and 95% by mass or less, more preferably 40% by mass or more and 94% by mass or less, and even more preferably 50% by mass or more and 92% by mass or less.

[0034] ((D) component) The solid detergent preparation of the present invention contains, as component (D), at least one selected from the group consisting of calcium silicate, dextrin, lactose, starch, gum arabic, gelatin, casein, and talc. One or a combination of two or more of these may be used. The component (D) is not limited to, but is preferably calcium silicate, dextrin, and / or lactose.

[0035] The content of component (D) relative to the total amount of the solid cleaning preparation of the present invention may vary depending on the mass per unit of the solid cleaning preparation. From the viewpoint of achieving the effects of the present invention, however, it is preferably from 0.1% by mass to 50% by mass, more preferably from 0.2% by mass to 40% by mass, and even more preferably from 0.5% by mass to 30% by mass.

[0036] In the solid preparation for detergent of the present invention, the ratio of component (D) to component (A) is preferably 0.1 to 12.5 parts by mass, more preferably 0.15 to 8 parts by mass, and even more preferably 0.2 to 6 parts by mass of component (D) per 1 part by mass of component (A).

[0037] In the solid preparation for detergent of the present invention, the ratio of component (D) to the aqueous solvent to be mixed with component (A) is preferably 0.12 to 20 parts by mass, more preferably 0.2 to 15 parts by mass, and even more preferably 0.5 to 12 parts by mass of component (D) per 1 part by mass of the aqueous solvent to be mixed with component (A).

[0038] (Other ingredients) In addition to the components (A), (B), (C), and (D), the solid detergent preparation of the present invention may contain optional components, such as surfactants, binders, enzymes, flow improvers, stabilizers, deodorizers, rust inhibitors, fragrances, and / or colorants, as long as the optional components do not impair the effects of the present invention.

[0039] As the surfactant, any of anionic surfactants, nonionic surfactants and amphoteric surfactants can be used, but anionic surfactants are particularly preferred.

[0040] Examples of such anionic surfactants include alkylbenzenesulfonates, olefinsulfonates, alkylsulfoacetates, alkyl sulfates, and alkanesulfonates. Among these, alkyl sulfates or olefinsulfonates having an alkyl group with 8 to 16 carbon atoms are particularly preferred, sulfates or olefinsulfonates having a lauryl group or a myristyl group are more preferred, and sodium lauryl sulfate or sodium olefinsulfonate is even more preferred. At least one of these may be used, or two or more may be used in combination.

[0041] Examples of nonionic surfactants include sorbitan fatty acid esters, propylene glycol fatty acid esters, hydrogenated castor oil derivatives, polyoxyethylene sorbitan fatty acid esters, glycerin derivatives, and polyoxyalkylene alkyl ethers.

[0042] Examples of amphoteric surfactants include alkyl betaines, fatty acid amidopropyl betaines, alkyl imidazoles, lauroyl glutamate salts, and amine oxides.

[0043] Examples of binders include polyvinylpyrrolidone, polyoxyethylene, polyethylene glycol, carbowax, sodium carboxymethylcellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, cellulose, etc. These binders may be used alone or in combination of two or more. At least one of these may be used, or two or more may be used in combination. The binder is not limited, but for example, polyethylene glycol or a cellulose derivative having a molecular weight of about 1000 to 10,000 is preferred.

[0044] Examples of enzymes include protease, alcalase, amylase, lipase, dextranase, mutanase, and glucanase. These enzymes may be used alone or in combination of two or more. Among these, proteases such as papain are preferred.

[0045] Examples of flow improvers (lubricants) include talc, magnesium stearate, magnesium oxide, talc, and finely powdered anhydrous silicic acid.

[0046] As the rust inhibitor, aromatic carboxylic acid sodium salt, chromate, molybdate, tungstate, nitrite, polymerized phosphate, zinc salt, mercaptone benzothiazole, benzotriazole, alkanolamine, fatty acid salt, alkylamine ethylene oxide adduct, alkyl phosphate ester salt, petroleum sulfonate, diisopropylamine nitrite, or dicyclohexylammonium nitrite is preferred, and nitrite or aromatic carboxylic acid sodium salt is particularly preferred.

[0047] (pH) From the viewpoint of the stability or safety of the components, when 3 g of the solid preparation for cleansing of the present invention is dissolved in 150 ml of water and measured at 20° C., it is preferable that the solid preparation for cleansing of the present invention can give a solution with a pH of 1 to 9, and more preferably a solution with a pH of 1.5 to 8.5. The pH can be measured at 20° C. using a commercially available pH meter (for example, Model F-52 (registered trademark) manufactured by Horiba, Ltd.).

[0048] (Applications, etc.) The solid preparation for cleansing of the present invention is a solid preparation for cleansing oral appliances, which refer to dentures, orthodontic retainers, sports mouthpieces, and containers for these appliances.

[0049] The solid preparation for cleansing of the present invention is dissolved in a solvent such as water, and the resulting solution is used for immersing the oral cavity-wearable appliance.

[0050] The solid preparation for cleaning of the present invention may be provided in the form of, but is not limited to, a tablet or granules. Preferably, it is a tablet. The shape, mass, hardness, etc. of the tablet are not particularly limited.

[0051] The solid preparation for cleaning of the present invention may preferably have a shape such as a sphere, a cylinder, an oval sphere, or a polygonal prism, although the shape is not limited thereto.

[0052] The solid preparation for cleaning of the present invention preferably has a mass per tablet of, but not limited to, about 0.5 to 20 g, more preferably about 1 to 10 g, and even more preferably about 1 to 5 g.

[0053] The diameter of a tablet of the solid preparation for cleaning of the present invention is preferably, but not limited to, about 100 to 400 mm, more preferably 150 to 300 mm.

[0054] The solid preparation for cleaning of the present invention preferably has a hardness of, but is not limited to, about 45 N or more, preferably about 35 to 130 N, more preferably about 40 to 125 N, and even more preferably about 45 to 120 N.

[0055] The solid preparation for cleansing of the present invention can be used about once or twice a day, or about once every 2 to 7 days.

[0056] The specific manner of use of the solid preparation for cleansing of the present invention is not limited, but typically, for example, the tablet is dissolved in about 50 to 300 mL of water, preferably about 100 to 200 mL of water, and more preferably about 150 mL of water, and a control oral appliance is immersed in the solution, allowed to stand for about 3 minutes to overnight, and then the oral appliance is thoroughly washed with water.

[0057] [How to improve dispersibility] The present invention also relates to a method for improving the dispersibility of a solid detergent preparation by incorporating (A) at least one selected from the group consisting of dichloroisocyanurate, a quaternary ammonium salt, isopropylmethylphenol, fluoride, thymol, hinokitiol, cetylpyridinium chloride, benzethonium chloride, chlorhexidine acetate, chlorhexidine gluconate, sodium monofluorophosphate, triclosan, lysozyme chloride, and chlorhexidine hydrochloride, (B) an oxygen bleaching agent, (C) a foaming agent, and (D) at least one selected from the group consisting of calcium silicate, dextrin, lactose, starch, gum arabic, gelatin, casein, and talc, and adjusting the amount of component (D) to be 0.2 parts by mass or more and 5 parts by mass or less per part by mass of component (A).

[0058] In the present invention, dispersibility refers to the degree to which the ingredients are uniformly dispersed in the tablet.

[0059] Other conditions are as described in [Solid preparations for cleaning]. [Example]

[0060] Next, the present invention will be described in detail with reference to examples, but the present invention is not limited to the following examples. Note that the unit of the amount of each component in the tables is % by mass unless otherwise specified in the tables.

[0061] [1] Stability test of the mixture of raw materials during tableting For the Examples and Comparative Examples having the formulations shown in Table 1, the stability of the mixture of raw materials during tableting was evaluated.

[0062] The stability of the mixture of raw materials during tableting was evaluated specifically as follows.

[0063] (Method for preparing a mixture of raw materials) In the formulations of the Examples and Comparative Examples shown in Table 1, each raw material was weighed into a beaker to make a total of 100 g. This was stirred until homogenous to obtain a raw material mixture (powder). 3 g of this raw material mixture was tableted using a tablet press with a die having a diameter of approximately 24 mm to produce prototype tablets.

[0064] The mixture of raw materials during tableting was evaluated as follows. 〇: The raw material mixture (powder) can be tableted without any problems ×: The tablet is difficult to press because it becomes lumpy or sticky (adheres to the punches and dies of the tablet press).

[0065] As a result of the evaluation test, the formulations of the Examples were found to have superior stability during tableting compared to the formulations of the Comparative Examples.

[0066] [2] Dispersibility test Dispersibility of tablets was evaluated for the Examples and Comparative Examples having the formulations shown in Table 1. Dispersibility here refers to the degree to which raw materials are uniformly dispersed in the tablet.

[0067] The dispersibility of the preparation was evaluated as follows.

[0068] (Method of preparing tablets) A 3g tablet was prepared using the same preparation method as in the test [1].

[0069] (Method for confirming the dispersibility of the formulation) One tablet prepared as above was crushed with a mortar and pestle to obtain tablet powder. 1 g of this powder was placed in a 20 mL measuring flask, and the mobile phase was added to make exactly 20 mL. The benzalkonium chloride content was measured using liquid chromatography (HPLC) under the following conditions. Ten tablets of each formulation were prepared in the same manner, and the same measurement test was performed to measure the benzalkonium chloride content of each tablet and confirm dispersibility. <Liquid chromatography (HPLC) measurement conditions> Column used: STR ODS-II (Shinwa Chemical Co., Ltd., 150 mm x φ4.6 mm) Mobile phase: methanol / water mixture (1:1) Flow rate: 1.0mL / min Column temperature: 40℃ Detector: Ultraviolet absorption spectrophotometer (Shimadzu Corporation, LC-2010) Detection wavelength: 210 nm Sample injection volume: 20 μL

[0070] The relative standard deviation was calculated from the measured values ​​of 10 tablets of each formulation for the content of benzalkonium chloride in the tablets of each formulation by liquid chromatography, and the results were ○: Less than 0.3 △: 0.3 or more and less than 0.6 ×: 0.6 or more It was evaluated as follows.

[0071] As a result of the evaluation test, the preparations of the Examples had superior dispersibility of benzalkonium chloride compared to the preparations of the Comparative Examples.

[0072] [3] Bactericidal efficacy evaluation test [1] The same preparation method was used to prepare 3g tablets. These tablets were evaluated for bactericidal efficacy.

[0073] The evaluation of the bactericidal effect was specifically carried out as follows.

[0074] (Target bacteria) Candida albicans

[0075] (Culture medium used for bacterial culture) GP agar medium (glucose peptone agar medium) supplemented with lecithin and polysorbate 80 was used.

[0076] (Method for preparing bacteria-adherent dentures) The tablets of the Examples and Comparative Examples shown in Table 1 were dissolved in 150 mL of water. 5 ~10 6After adding the solution to a concentration of cfu / mL, the mixture was mixed thoroughly. The solution was then stored at 25°C, and the viable cell count in the test solution was measured after 10 hours.

[0077] The amount of bacteria after the action was divided by the amount of bacteria before the action to calculate the bacterial reduction value. Reduces viable bacteria count to 1 / 100 or less: ◎ Viable bacteria count is 1 / 10 or less, over 1 / 100: The number of live bacteria does not decrease to 1 / 10 or less: × It was evaluated as follows.

[0078] As a result of the evaluation test, the preparations of the Examples showed a higher bactericidal effect than the preparations of the Comparative Examples.

[0079] [Table 1]

Claims

1. (A) at least one selected from the group consisting of dichloroisocyanurate, quaternary ammonium salt, isopropylmethylphenol, fluoride, thymol, hinokitiol, cetylpyridinium chloride, benzethonium chloride, chlorhexidine acetate, chlorhexidine gluconate, sodium monofluorophosphate, triclosan, lysozyme chloride, and chlorhexidine hydrochloride; (B) an oxygen bleach; (C) a foaming agent; and (D) at least one selected from the group consisting of calcium silicate, dextrin, lactose, starch, gum arabic, gelatin, casein, and talc; A solid preparation for cleaning an intraoral appliance, comprising 0.2 to 5 parts by mass of the component (D) per 1 part by mass of the component (A).

2. 2. The solid preparation for cleaning according to claim 1, which is in the form of a tablet.

3. 2. The solid preparation for cleaning according to claim 1, wherein the component (A) is at least one selected from the group consisting of quaternary ammonium salts, isopropylmethylphenol, and cetylpyridinium chloride.

4. 2. The solid preparation for cleaning according to claim 1, wherein the component (B) is at least one selected from the group consisting of hydrogen persulfates, persulfates, percarbonates, and perborates.

5. 2. The solid detergent formulation according to claim 1, wherein the component (C) is a combination of a carbonate or bicarbonate and succinic acid, sulfamic acid, or citric acid.

6. A method for improving the dispersibility of a solid detergent preparation by containing (A) at least one selected from the group consisting of dichloroisocyanurate, a quaternary ammonium salt, isopropylmethylphenol, fluoride, thymol, hinokitiol, cetylpyridinium chloride, benzethonium chloride, chlorhexidine acetate, chlorhexidine gluconate, sodium monofluorophosphate, triclosan, lysozyme chloride, and chlorhexidine hydrochloride, (B) an oxygen-based bleaching agent, (C) a foaming agent, and (D) at least one selected from the group consisting of calcium silicate, dextrin, lactose, starch, gum arabic, gelatin, casein, and talc, and adjusting the amount of component (D) to be 0.2 parts by mass or more and 5 parts by mass or less per part by mass of component (A).

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