Scalp and hair improving agent

Abstract

To provide a scalp and hair improving agent that improves or prevents hair trouble conditions such as hair firmness and hair resilience, and scalp trouble conditions such as scalp moisturization and dandruff prevention, with safety and with a low burden even on sensitive scalp and hair, without depending on special treatments or agents.SOLUTION: A scalp and hair improving agent comprises a composition containing a lipid membrane structure formed from a phospholipid having an acid value of 5 mgKOH / g or more.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a scalp hair improving agent that forms a lipid membrane structure containing a specific phospholipid. [Background technology]

[0002] In modern society, where beauty and health are highly valued, improving hair quality and scalp health have become important concerns for many people. Hair firmness and body are elements that symbolize healthy, youthful hair, and improving their quality has a significant impact on a person's self-confidence and appearance. Furthermore, scalp health is directly related to hair health, and preventing dandruff, in particular, is one of the basic measures for avoiding scalp problems. Conventional technologies have developed a wide variety of shampoos, rinses, and treatments to improve hair texture and maintain scalp cleanliness. These products offer certain benefits, such as the cleansing power of surfactants and the moisturizing effect of plant-derived ingredients. However, these conventional products can cause scalp irritation and excessive strain on the hair with long-term use. Liposomes, lipid membrane structures primarily composed of phospholipids, have been known to be useful in skin care (Patent Document 1). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Patent No. 6778306 Summary of the Invention [Problem to be solved by the invention]

[0004] As described above, it is known that lipid membrane structures mainly composed of phospholipids are useful in skin care as carriers of active ingredients, but their effects as scalp and hair improving agents, such as improving hair firmness, improving hair strength, improving scalp moisture retention, and preventing scalp dandruff, are not known. In view of the above circumstances, the problem to be solved by the present invention is to provide a scalp and hair improving agent that improves or prevents hair troubles such as loss of hair firmness and strength, and scalp troubles such as scalp moisturization and prevention of scalp dandruff, without relying on special treatments or chemicals, and with little burden on sensitive hair and scalp, safely. [Means for solving the problem]

[0005] As a result of extensive research, the inventors discovered that the above problems can be solved by using a lipid membrane structure formed from a phospholipid having a specific acid value as a scalp hair improvement agent, and thus completed the present invention.

[0006] That is, the present invention is as follows. [1] A scalp and hair improving agent comprising a composition containing a lipid membrane structure formed from phospholipids having an acid value of 5 mgKOH / g or more. [2] The scalp and hair improvement agent according to [1] above, wherein the phospholipid is a hydrogenated phospholipid. [3] The scalp and hair improvement agent according to the above [1] or [2], wherein the lipid membrane structure is a single-layer lamellar structure. [4] The scalp and hair improvement agent according to [1] or [2] above, wherein the lipid membrane structures have an average hydrodynamic diameter of 200 nm or less. [5] The scalp and hair improvement agent according to [1] or [2] above, which has the effect of improving hair firmness. [6] The scalp and hair improvement agent according to [1] or [2] above, which has the effect of improving hair stiffness. [7] The scalp and hair improvement agent according to [1] or [2] above, which has the effect of improving hair gloss. [8] The scalp and hair improvement agent according to [1] or [2] above, which has the effect of improving hair gloss. [9] The scalp and hair improvement agent according to [1] or [2] above, which has a hair moisturizing improving effect.

[10] The scalp and hair improvement agent according to [1] or [2] above, which has the effect of reducing hair frizz.

[11] The scalp and hair improving agent according to [1] or [2] above, which has a split end prevention effect.

[12] The scalp and hair improvement agent according to [1] or [2] above, which has the effect of suppressing color fading.

[13] The scalp and hair improving agent according to [1] or [2] above, which has a bedhead preventing effect.

[14] The scalp and hair improvement agent according to [1] or [2] above, which has the effect of eliminating bedhead.

[15] The scalp and hair improvement agent according to [1] or [2] above, which has a hair surface repair effect.

[16] The scalp and hair improvement agent according to [1] or [2] above, which has a scalp moisturizing improving effect.

[17] The scalp and hair improvement agent according to [1] or [2] above, which has a scalp dandruff prevention effect.

[18] The scalp and hair improvement agent according to [1] or [2] above, which has an effect of improving scalp itching.

[19] The scalp and hair improvement agent according to [1] or [2] above, which has an anti-inflammatory effect on the scalp.

[20] The scalp and hair improving agent according to [1] or [2] above, which has a scalp odor suppressing effect. [twenty one] The scalp and hair improvement agent according to [1] or [2] above, which has a hair growth effect. [twenty two] The scalp and hair improving agent according to [1] or [2] above, which has a hair growth effect. [twenty three] The scalp and hair improvement agent according to [1] or [2] above, which has an effect of improving gray hair. [Effects of the Invention]

[0007] The present invention can provide a scalp and hair improving agent that improves or prevents hair troubles such as loss of hair firmness and strength, scalp troubles such as scalp moisturization and prevention of scalp dandruff, safely with little burden on sensitive hair and scalp, without relying on special treatments or chemicals. [Brief explanation of the drawings]

[0008] [Figure 1] 1 shows a photograph of the lipid membrane structure formed in Example 5, observed by cryo-electron microscopy (Cryo-TEM). DETAILED DESCRIPTION OF THE INVENTION

[0009] Hereinafter, a mode for carrying out the present invention (hereinafter also referred to as "the present embodiment") will be described in detail. Note that the present invention is not limited to the present embodiment, and various modifications can be made within the scope of the gist of the present invention.

[0010] The scalp hair improvement agent of this embodiment is a scalp hair improvement agent that includes a composition containing a lipid membrane structure formed from a phospholipid having an acid value of 5 mgKOH / g or more (hereinafter also referred to as a "lipid membrane structure-containing composition").

[0011] As used herein, "lipid membrane structures" refers to particles having a lamellar (lipid bilayer) structure in which lipid molecules are arranged with their hydrophilic groups facing outward and their hydrophobic groups facing each other. Specific forms include those described in the section below titled "Lipid Membrane Structure-Containing Composition." Furthermore, as used herein, lipid membrane structures are considered to have been formed if the mean hydrodynamic diameter of a lipid membrane structure-containing composition prepared using a composition for forming lipid membrane structures can be measured using a dynamic light scattering measurement device, more specifically, a Zetasizer Nano ZSP (manufactured by Malvern Instruments).

[0012] <Composition for forming lipid membrane structure> The composition for forming lipid membrane structures in this embodiment is a composition for obtaining a lipid membrane structure-containing composition. The components of the composition for forming lipid membrane structures will be described below.

[0013] [Component (A)] The composition for forming a lipid membrane structure in this embodiment contains, as component (A), a phospholipid having an acid value of 5 mgKOH / g or more. The phospholipid having an acid value of 5 mgKOH / g or more may be one or more types, or may be a combination of one or more phospholipids having an acid value of less than 5 mgKOH / g and one or more phospholipids having an acid value of 5 mgKOH / g or more, to achieve an acid value of 5 mgKOH / g or more.

[0014] The origin of the phospholipid is not particularly limited, but lecithin is particularly preferred because it is naturally derived and can be suitably used in cosmetics and scalp and hair external preparations.The lecithin may be derived from soybean, egg yolk, rapeseed, sunflower, corn, etc., and is preferably derived from plants such as soybean, rapeseed, sunflower, corn, etc., and is more preferably derived from soybean in view of easy availability and quality stability.

[0015] The phospholipid is preferably a hydrogenated phospholipid from the viewpoints of preventing oxidative deterioration due to heating processes in the production of cosmetics and quasi-drugs, oxidative deterioration during storage of these products, preventing accelerated oxidation of lipids in the stratum corneum and keratinocytes around the scalp due to oxidative deterioration of phospholipids and their lipid membrane structures, maintaining and strengthening the structure of stratum corneum intercellular lipids (barrier function) when the lipid membrane structures penetrate deep into the stratum corneum after application, strengthening the barrier function of the lipid membrane formed on the scalp by the lipid membrane structures remaining on the stratum corneum surface, and repairing and strengthening the structure of hair surface and deep hair. Hydrogenated phospholipids can be obtained by adding hydrogen atoms to the unsaturated carbon bonds of phospholipids using conventional methods. Hydrogenated lecithin is particularly preferred as the hydrogenated phospholipid.

[0016] The acid value of the phospholipid used in this embodiment is 5 mg KOH / g or more. When a phospholipid with an acid value of less than 5 mg KOH / g is used, the dispersibility of the lipid membrane structure deteriorates, and sufficient scalp hair improvement effect cannot be obtained. From the viewpoint of obtaining a finer lipid membrane structure, the acid value of the phospholipid is preferably 6, 7, 8, 9, 10, or 11 mg KOH / g or more, more preferably 12, 13, or 14 mg KOH / g or more, even more preferably 15 or 16 mg KOH / g or more, even more preferably 17, 18, or 19 mg KOH / g or more, particularly preferably 20 or 21 mg KOH / g or more, and particularly preferably 22, 23, 24, 25, 26, or 27 mg KOH / g or more. The upper limit of the acid value of the phospholipid is not particularly limited, and is, for example, 70 mg KOH / g or less, 60 mg KOH / g or less, 50 mg KOH / g or less, or 40 mg KOH / g or less. By appropriately selecting the type of phospholipid, it is possible to obtain a phospholipid with the desired acid value. The acid value of the phospholipid is measured in accordance with "28. Acid Value Measurement Method, Part of General Test Methods, Quasi-drug Ingredients Standards 2021."

[0017] The phospholipid may be either a synthetic product or a commercially available product. Examples of commercially available products include EMALEX (registered trademark) SLP manufactured by Nippon Emulsion Co., Ltd. and SLP-White H manufactured by Tsuji Oil Mills Co., Ltd. These may be used alone or in combination of two or more types.

[0018] The content of phospholipid in the composition for forming a lipid membrane structure in this embodiment is not particularly limited, but the lower limit is preferably 5% by mass or more, and more preferably 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, or 19% by mass or more. The upper limit is preferably 50% by mass or less, and more preferably 45, 40, 35, 30, 25, or 20% by mass or less. When the phospholipid content is 5% by mass or more, lipid membrane structures are efficiently formed when the composition for forming a lipid membrane structure is dispersed in water, and sufficient scalp hair improvement effects tend to be obtained. When the phospholipid content is 50% by mass or less, component (A) is more easily dissolved or dispersed in the composition for forming a lipid membrane structure. Therefore, by using the composition for forming a lipid membrane structure, lipid membrane structures with excellent dispersibility in an aqueous phase are easily formed, and the stability of the lipid membrane structure-containing composition over time tends to be improved.

[0019] [(B) Component] The composition for forming a lipid membrane structure in this embodiment may contain, as component (B), a compound represented by the following formula 1. The component (B) may be one type or two or more types.

[0020] [ka]

[0021] In the above formula 1, R is a substituted or unsubstituted alkyl group having 2 to 6 carbon atoms or a substituted or unsubstituted cycloalkyl group having 3 to 6 carbon atoms.

[0022] The alkyl group having 2 to 6 carbon atoms may be either linear or branched. Examples of the alkyl group having 2 to 6 carbon atoms include ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, iso-amyl, tert-pentyl, neopentyl, n-hexyl, 3-methylpentan-2-yl, 3-methylpentan-3-yl, 4-methylpentyl, 4-methylpentan-2-yl, 1,3-dimethylbutyl, 3,3-dimethylbutyl, and 3,3-dimethylbutan-2-yl. The alkyl group having 2 to 6 carbon atoms is preferably linear. That is, the alkyl group having 2 to 6 carbon atoms is preferably a group selected from the group consisting of ethyl, n-propyl, n-butyl, n-pentyl, and n-hexyl.

[0023] Examples of the cycloalkyl group having 3 to 6 carbon atoms include a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, and a cyclohexyl group, and preferably a cyclohexyl group.

[0024] The substituents on the alkyl group having 2 to 6 carbon atoms and the cycloalkyl group having 3 to 6 carbon atoms are not particularly limited as long as they do not impair the effects of the present invention. Examples of the substituents include halogen atoms, acyl groups, alkyl groups, aryl groups, alkoxyl groups, nitro groups, amino groups, and cyano groups. However, the alkyl group having 2 to 6 carbon atoms is not substituted with an alkyl group.

[0025] In the above formula 1, X is -O-, -C(=O)O-, or -OC(=O)-, and is preferably -O-. Furthermore, in the above formula 1, n is 0 or 1. In the above formula 1, when X is -O- and n is 1, the number of carbon atoms in the alkyl group represented by R is preferably 4 or more.

[0026] The component (B) is preferably at least one selected from the group consisting of, for example, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, cyclohexylglycerin, and hexylglycerin.

[0027] In particular, when 1,2-hexanediol, 1,2-heptanediol, or hexylglycerin is used as component (B), extremely fine lipid membrane structures can be formed. In this case, the lipid membrane structures are thought to form bicelles. Because bicelles are disc-shaped single-layer lamellar structures, they have superior permeability to the stratum corneum of the scalp and hair compared to liposomes of comparable particle size. Therefore, from the perspective of obtaining lipid membrane structures with high permeability for lipid-soluble components, it is preferable to use at least one selected from the group consisting of 1,2-hexanediol, 1,2-heptanediol, and hexylglycerin as component (B).

[0028] Component (B) may be either a synthetic product or a commercially available product.

[0029] The content of component (B) in the composition for forming a lipid membrane structure of this embodiment is not particularly limited, but the lower limit is preferably 15% by mass or more, and more preferably 20, 25, 30, 35, 40, 45, or 50% by mass or more, and the upper limit is preferably 95% by mass or less, more preferably 90, 85, 80, 75, or 70% by mass or less, and even more preferably 65, 60, or 55% by mass or less.

[0030] In the composition for forming lipid membrane structures of this embodiment, the content of component (B) preferably exceeds 100 parts by mass per 100 parts by mass of component (A). When the content of component (B) exceeds 100 parts by mass per 100 parts by mass of component (A), fine lipid membrane structures tend to be easily formed. Furthermore, the content of component (B) is preferably 110, 120, 130, 140, or 150 parts by mass or more per 100 parts by mass of component (A). When the content is 150 parts by mass or more, component (A) becomes more easily dissolved or dispersed in the composition for forming lipid membrane structures, and therefore, by using this composition for forming lipid membrane structures, lipid membrane structures with excellent dispersibility in an aqueous phase tend to be formed. Furthermore, from the viewpoint of obtaining finer lipid membrane structures, the content of component (B) is preferably 160, 170, 180, 190, or 200 parts by mass or more, more preferably 210, 220, 230, 240, or 250 parts by mass or more, even more preferably 260, 270, 280, 290, or 300 parts by mass or more, still more preferably 310, 320, 330, 340, or 350 parts by mass or more, and particularly preferably 360, 370, 380, 390, or 400 parts by mass or more, per 100 parts by mass of component (A). On the other hand, although there is no particular upper limit to the content of component (B) per 100 parts by mass of component (A), even if it exceeds 2000 parts by mass, the solubility or dispersibility of component (A) in the composition for forming lipid membrane structures is minimally affected, making it uneconomical. Therefore, according to this embodiment, the content of component (B) is preferably 2000 parts by mass or less per 100 parts by mass of component (A). Therefore, according to this embodiment, the content of component (B) is preferably more than 100 parts by mass but not more than 2000 parts by mass per 100 parts by mass of component (A).

[0031] [(C) component] The composition for forming lipid membrane structures of this embodiment may further contain water as component (C). When component (A) with a high acid value is used, the combined use of components (B) and (C) can provide a composition for forming lipid membrane structures with superior solubility or dispersibility of component (A). Use of this composition for forming lipid membrane structures tends to enable the formation of lipid membrane structures with excellent dispersibility in the aqueous phase. Furthermore, component (C) also serves to facilitate the incorporation of component (D) (a basic compound) and component (E) (an acidic compound) into the composition for forming lipid membrane structures. Specifically, component (D) and / or component (E) can be easily incorporated into the composition for forming lipid membrane structures by dissolving component (D) and / or component (E) in component (C) beforehand and then mixing with component (A) and component (B).

[0032] Component (C) is preferably water with few impurities, such as purified water, which is purified from tap water using a system that employs ion exchange, distillation, reverse osmosis, or ultrafiltration, either alone or in combination.

[0033] The content of component (C) in the composition for forming a lipid membrane structure of this embodiment is not particularly limited, but the lower limit is preferably 0.5% by mass or more, more preferably 1, 2, 3, 4, or 5% by mass or more, even more preferably 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15% by mass or more, and particularly preferably 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25% by mass or more. The upper limit is preferably 75% by mass or less, more preferably 70, 65, or 60% by mass or less, even more preferably 55, 50, 45, or 40% by mass or less, and particularly preferably 35 or 30% by mass or less.

[0034] Furthermore, in the composition for forming lipid membrane structures of this embodiment, the mass ratio (B) / (C) of the component (B) to the component (C) is preferably 0.3 to 100. The lower limit of this mass ratio range may be 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, or 1.0. The upper limit of this mass ratio range may be 100, 90, 80, 70, 60, 50, 40, 30, 20, 10, 9, 8, 7, or 6. The mass ratio range is, for example, more preferably 0.5 to 9, and even more preferably 1.0 to 6.

[0035] [(D) component] The composition for forming lipid membrane structures of this embodiment may further contain a basic compound as component (D). When component (A) with a high acid value is used, the inclusion of component (D) makes it possible to obtain a composition for forming lipid membrane structures that has better solubility or dispersibility of component (A), and the use of this composition for forming lipid membrane structures tends to improve the dispersibility of lipid membrane structures in an aqueous phase. Component (D) may be one type or two or more types.

[0036] Examples of component (D) include inorganic bases such as sodium hydroxide, potassium hydroxide, and ammonia; basic amino acids such as arginine, lysine, and histidine; and amine compounds such as ethanolamine, diethanolamine, triethanolamine, 2-amino-2-methyl-1,3-propanediol (AMPD), and 2-amino-2-hydroxymethyl-1,3-propanediol (tromethamine). Among these, arginine is preferred.

[0037] The component (D) may be either a synthetic product or a commercially available product.

[0038] The content of component (D) in the composition for forming a lipid membrane structure of this embodiment is not particularly limited, but the lower limit is preferably 0.01% by mass or more, more preferably 0.02% by mass or more, and the upper limit is preferably 2% by mass or less, more preferably 1% by mass or less.

[0039] In the composition for forming a lipid membrane structure of this embodiment, the content of component (D) is preferably at least 0.05 parts by mass, more preferably at least 0.1 parts by mass, as a lower limit, relative to 100 parts by mass of component (A), and is preferably at most 10 parts by mass, more preferably at most 5 parts by mass.

[0040] [(E) component] The composition for forming lipid membrane structures of this embodiment may contain an acidic compound as component (E). By containing component (E), a composition for forming lipid membrane structures having superior solubility or dispersibility of component (A) can be obtained, and use of this composition for forming lipid membrane structures tends to improve the dispersibility of lipid membrane structures in an aqueous phase. Component (E) may be one type or two or more types.

[0041] Examples of component (E) include inorganic acids such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, and carbonic acid, and organic acids such as acetic acid, formic acid, propionic acid, butyric acid, citric acid, lactic acid, succinic acid, malic acid, tartaric acid, pyrrolidonecarboxylic acid (PCA), gluconic acid, benzoic acid, ethylenediaminetetraacetic acid (EDTA), etidronic acid, pentetic acid, and phytic acid. Among these, organic acids are preferred from the viewpoint of being able to obtain a composition for forming lipid membrane structures that has superior solubility or dispersibility for component (A).

[0042] In particular, from the viewpoint of obtaining a composition for forming lipid membrane structures with excellent solubility or dispersibility of component (A), forming lipid membrane structures with excellent dispersibility in an aqueous phase using the composition for forming lipid membrane structures, and improving the storage stability of the composition for forming lipid membrane structures and lipid membrane structure-containing compositions using the composition for forming lipid membrane structures, component (E) is preferably an organic acid with chelating activity. Component (A) may have the property of easily binding to metal ions. In this case, adding an organic acid with chelating activity as component (E) captures metal ions in the composition for forming lipid membrane structures, improving the storage stability of the composition for forming lipid membrane structures and making component (A) more soluble or dispersible, thereby obtaining a composition for forming lipid membrane structures with excellent solubility or dispersibility of component (A). It is presumed that the use of such a composition will enable the formation of lipid membrane structures with excellent dispersibility in an aqueous phase and storage stability. Preferred examples of organic acids having a chelating effect include citric acid, ethylenediaminetetraacetic acid (EDTA), etidronic acid, and pentetic acid, with ethylenediaminetetraacetic acid (EDTA) being more preferred.

[0043] The component (E) may be either a synthetic product or a commercially available product.

[0044] In the composition for forming a lipid membrane structure of this embodiment, the content of component (E) (in terms of free acid) is not particularly limited, but the lower limit is preferably 0.02% by mass or more, more preferably 0.04% by mass or more, and the upper limit is preferably 4% by mass or less, more preferably 2% by mass or less.

[0045] In the composition for forming a lipid membrane structure of this embodiment, the content of component (E) (in terms of free acid) per 100 parts by mass of component (A) is preferably at least 0.1 parts by mass, more preferably at least 0.2 parts by mass, and more preferably at most 20 parts by mass, more preferably at most 10 parts by mass.

[0046] From the viewpoint of increasing the solubility of components (D) and (E) in the composition for forming lipid membrane structures and controlling the pH of the composition when dispersed in an aqueous phase within a predetermined range, the composition for forming lipid membrane structures of this embodiment preferably contains both components (D) and (E). Such a composition for forming lipid membrane structures may be obtained by adding components (D) and (E) separately, or by adding salts of components (D) and (E).

[0047] The salts of component (D) and component (E) are not particularly limited, but examples include lysine hydrochloride; sodium citrate salts such as trisodium citrate; sodium phosphate salts such as disodium hydrogen phosphate; sodium benzoate; sodium ethylenediaminetetraacetic acid salts such as trisodium ethylenediaminetetraacetic acid (EDTA-3Na); and sodium diethylenetriaminepentaacetic acid salts such as pentasodium diethylenetriaminepentaacetic acid (pentasodium pentetate).

[0048] When the composition for forming lipid membrane structures contains the components (D) and (E), the mass ratio (D) / (E) of the components (D) and (E) is 0.2 to 10. The lower limit of this mass ratio range may be 0.3, 0.4, or 0.5. The upper limit of this mass ratio range may be 10, 9, 8, 7, 6, or 5. The mass ratio range is preferably 0.5 to 5, for example.

[0049] In the composition for forming a lipid membrane structure of this embodiment, the total content of components (D) and (E) is preferably 0.05% by mass or more, more preferably 0.1% by mass or more, as a lower limit, and preferably 4% by mass or less, more preferably 2% by mass or less, as an upper limit.

[0050] [Component (F)] The composition for forming lipid membrane structures of this embodiment may further contain a fat-soluble compound as component (F). When component (A) with a high acid value is used, a composition for forming lipid membrane structures with superior solubility or dispersibility of component (A) can be obtained by using component (B) and component (F) in combination. The use of this composition for forming lipid membrane structures tends to enable the formation of lipid membrane structures with excellent dispersibility in aqueous phases and high storage stability. Furthermore, the use of component (F) in combination with component (D) and / or component (E) tends to enable the formation of finer lipid membrane structures. The component (F) may be one type or two or more types.

[0051] Examples of component (F) include sterols such as phytosterols, cholesterol, di(phytosteryl / octyldodecyl) lauroyl glutamate, phytosteryl oleate, and phytosteryl glucoside; triterpenes such as γ-oryzanol, glycyrrhizic acid, ursolic acid, and Centella asiatica extract (a mixture of asiatic acid, madecassic acid, and asiaticoside); fat-soluble vitamins such as retinol, hydrogenated retinol, cholecalciferol, tocopherol, and ascorbic acid esters; and astaxanthin. carotenoids such as β-carotene; coenzymes such as ubiquinone; hydrocarbons such as limonene, petrolatum, and squalane; ceramides such as ceramide EOS, ceramide NG (ceramide 2), ceramide NP (ceramide 3), ceramide AP (ceramide 6II), ceramide EOP (ceramide 1), dihydroxylignoceroylphytosphingosine, cerebrosides, glycosphingolipids, and cetyl PG hydroxyethyl palmitamide; and polyphenols such as tetrahydrodiferuloylmethane and pterostilbene. Among these, from the viewpoint that combining component (F) with components (A) and (B) mutually enhances the solubility of components (A) and (F), resulting in a composition for forming lipid membrane structures with excellent solubility of component (A), ease of blending component (F), and good storage stability, and from the viewpoint of improving the storage stability of lipid membrane structure-containing compositions using the composition for forming lipid membrane structures, it is preferable that component (F) is at least one selected from the group consisting of phytosterols, cholesterol, γ-oryzanol, glycyrrhizinic acid, ursolic acid, Centella asiatica extract (a mixture of asiatic acid, madecassic acid, and asiaticoside), hydrogenated retinol, tocopherol, astaxanthin, ubiquinone, ceramide NG, ceramide NP, ceramide AP, ceramide EOP, tetrahydrodiferuloylmethane, and pterostilbene.

[0052] Component (F) may be either a synthetic product or a commercially available product, such as Phytosterol-SKP (manufactured by Tama Biochemical Co., Ltd.), TECA (manufactured by Bayer), dl-α-tocopherol (manufactured by DSM K.K.), NIKKOL® Retinol H10, NIKKOL® VC-IP, and squalane (manufactured by Nikko Chemicals Co., Ltd.), astaxanthin-20C and γ-oryzanol (manufactured by Oryza Oil & Fat Chemical Co., Ltd.), Kaneka Coenzyme Q10 (manufactured by Kaneka Corporation), CERAMIDE2 (manufactured by Croda Japan Co., Ltd.), and ursolic acid 90%, Sabi White, and Ptero White (manufactured by Sabinsa Japan Corporation).

[0053] The content of component (F) in the composition for forming a lipid membrane structure of the present invention is not particularly limited, but the lower limit is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.1% by mass or more, and particularly preferably 1% by mass or more, and the upper limit is preferably 12% by mass or less, more preferably 10% by mass or less, even more preferably 8% by mass or less, and particularly preferably 6% by mass or less.

[0054] Furthermore, in the composition for forming a lipid membrane structure of this embodiment, the content of component (F) is, relative to 100 parts by mass of component (A), preferably 0.005 parts by mass or more, more preferably 0.05 parts by mass or more, even more preferably 0.5 parts by mass or more, and particularly preferably 5 parts by mass or more, as a lower limit, and preferably 60 parts by mass or less, more preferably 50 parts by mass or less, even more preferably 40 parts by mass or less, and particularly preferably 30 parts by mass or less, as an upper limit.

[0055] [Other ingredients] The lipid membrane structure-forming composition of this embodiment may further contain components (other components) other than the above components (A) to (F). The other components are not particularly limited, and examples thereof include oils, surfactants, moisturizers, whitening agents, colorants, alcohols, amino acids, sugars, vitamins, viscosity modifiers, polymers, colorants, powders, UV absorbers, preservatives, antibacterial agents, antioxidants, fragrances, cosmetic ingredients, electrolytes, fibers, and plant extracts. These may be used alone or in combination of two or more. For example, by blending a cosmetic ingredient such as a moisturizer or whitening agent into the lipid membrane structure-forming composition and dispersing the lipid membrane structure-forming composition in an aqueous phase, lipid membrane structures encapsulating the cosmetic ingredient can be formed. When forming lipid membrane structures encapsulating the cosmetic ingredient, the timing of blending the cosmetic ingredient is not particularly limited. For example, a lipid membrane structure-forming composition containing ingredients other than the cosmetic ingredient may be prepared and then stored, and when preparing a lipid membrane structure-containing composition, the cosmetic ingredient may be added to the lipid membrane structure-forming composition, dissolved uniformly, and then dispersed in an aqueous phase to form lipid membrane structures encapsulating the cosmetic ingredient. Thus, the lipid membrane structure-forming composition not only simplifies the production of individual scalp and hair improving agents, but also allows different product groups to be easily produced by stocking the lipid membrane structure-forming composition in advance and changing the encapsulated cosmetic ingredient as desired.

[0056] From the viewpoint of obtaining finer lipid membrane structures, the pH of the composition for forming lipid membrane structures when dispersed in an aqueous phase is preferably 4.0 or higher, more preferably 5.0 or higher, even more preferably 7.0 or higher, and even more preferably 8.0 or higher. On the other hand, from the viewpoint of obtaining lipid membrane structures with uniform particle size (i.e., a composition containing lipid membrane structures with high uniformity), the pH of the composition for forming lipid membrane structures when dispersed in an aqueous phase is preferably 10.0 or lower, more preferably 9.5 or lower, and even more preferably 9.0 or lower. That is, the composition for forming lipid membrane structures of this embodiment preferably has a pH of 4.0 to 10.0 when dispersed in an aqueous phase. Here, the "pH of the composition for forming lipid membrane structures when dispersed in an aqueous phase" refers to the pH of the product obtained by dispersing the composition for forming lipid membrane structures in an aqueous phase, and is measured by the following method. 100 mL of purified water is added to a 200 mL beaker to prepare an aqueous phase. The aqueous phase is heated to 80°C, and the above-prepared composition for forming lipid membrane structures at 80°C is added while stirring at 100 rpm. After the addition is complete, the mixture is stirred at 80°C for 2 minutes to prepare a lipid membrane structure-containing composition. The above-prepared lipid membrane structure-containing composition is allowed to cool naturally to room temperature (25°C), and the pH at 25°C is measured using a glass electrode pH meter (HM-25R, manufactured by DKK-Toa Corporation).

[0057] <Composition containing lipid membrane structure> The lipid membrane structure-containing composition of this embodiment is a composition containing lipid membrane structures formed from phospholipids with an acid value of 5 mgKOH / g or more, and can be obtained using the lipid membrane structure-forming composition described above. However, as long as the composition contains lipid membrane structures formed from phospholipids with an acid value of 5 mgKOH / g or more, it will exhibit the effects of the scalp hair improving agent of this embodiment, and therefore the production method is not particularly limited, and known methods can be used. For example, fine monolayer lamellar structures may be prepared using the sonication method, ethanol injection method, or cholic acid removal method. In addition, in methods for preparing lipid membrane structures containing multilayer lamellar structures, such as the Bangham method or polyhydric alcohol method, fine lipid membrane structures may be prepared by combining a high-pressure emulsifier such as a microfluidizer or a micronization method such as an extrusion method. When forming lipid membrane structures using such known methods, the composition for forming lipid membrane structures described above is not limited to its composition, except that the lipid membrane structure contains a phospholipid with an acid value of 5 mgKOH / g or more as a component, and components and steps suitable for each production method may be used.

[0058] The form of the lipid membrane structure is not particularly limited as long as it has a lamellar (lipid bilayer) structure in which lipid molecules are arranged with their hydrophilic groups facing outward and their hydrophobic groups facing inward, and examples thereof include liposomes, bicelles, and α-gels. The lipid membrane structure may be a single-layer lamellar structure called a unilamellar or single lamellar structure, a multi-layer lamellar structure called an oligolamellar structure (2 to 10 layers), or a multi-layer structure with more layers, or a mixture of these. The lipid membrane structure is preferably a single-layer lamellar structure. A single-layer lamellar structure has a fine particle size and excellent compound encapsulation efficiency and permeability. The fact that the lipid membrane structure is a single-layer lamellar structure can be confirmed, for example, using cryo-electron microscopy (cryo-TEM). In this embodiment, the lipid membrane structure is preferably a single-layer lamellar liposome. A single-layer lamellar liposome has a fine particle size and a large internal aqueous phase volume, resulting in excellent water-soluble compound encapsulation efficiency and permeability. Therefore, it is useful in scalp and hair improvement agents that contain water-soluble cosmetic ingredients. In the present embodiment, the lipid membrane structures are preferably bicelles. Bicelles are fine, disc-shaped, unilamellar structures with a thickness of 3 to 10 nm and a diameter of 15 to 100 nm, and are excellent in encapsulation efficiency and penetration of fat-soluble ingredients. Therefore, it is useful in scalp and hair improvement agents that contain fat-soluble cosmetic ingredients. The lipid membrane structure-containing composition of the present embodiment may contain only one type of unilamellar liposome or bicelles, or these two types may be mixed.

[0059] The upper limit of the average hydrodynamic diameter of the lipid membrane structures is preferably 200 nm or less, more preferably 190, 180, 170, 160, 150, 140, 130, 120, 110, 100, 90, or 80 nm or less, from the viewpoints of dispersibility, storage stability, and permeability into scalp hair. The lower limit of the average hydrodynamic diameter of the lipid membrane structures is not particularly limited, but is, for example, 20 nm or more, from the viewpoint of the efficiency of forming unilamellar structures.

[0060] From the viewpoints of dispersibility, storage stability, and permeability into scalp and hair, the upper limit of the polydispersity index (PDI) of the lipid membrane structures is preferably 0.80 or less, more preferably 0.50 or less, even more preferably 0.40 or less, still more preferably 0.30 or less, still more preferably 0.25 or less, and particularly preferably 0.20 or less. The lower limit of the polydispersity index (PDI) of the lipid membrane structures is not particularly limited, but is, for example, 0.01 or more.

[0061] The average hydrodynamic diameter and polydispersity index (PDI) of the lipid membrane structures were measured using a dynamic light scattering analyzer (Malvern Instruments, Zetasizer Nano ZSP) and the harmonic mean diameter (Z-Average) and polydispersity index (PDI) based on scattered light intensity obtained by cumulant analysis were used. The definitions of the average hydrodynamic diameter and polydispersity index used here are as described in "JIS Z8828:2019 Particle Size Analysis - Dynamic Light Scattering."

[0062] From the viewpoint of obtaining a sufficient scalp hair improving effect, the concentration of the lipid membrane structures in the lipid membrane structure-containing composition is preferably 0.0001% by mass or more, more preferably 0.01% by mass or more, and even more preferably 1% by mass or more. On the other hand, the upper limit of the concentration is not particularly limited, but is, for example, less than 5% by mass.

[0063] The pH of the lipid membrane structure-containing composition is preferably 4.0 to 10.0, specifically, the pH measured using a pH meter (HM-25R, manufactured by DKK-TOA Corporation) using the glass electrode method.

[0064] <Method of producing lipid membrane structure-containing composition> The method for producing the lipid membrane structure-containing composition of the present invention is not particularly limited. When lipid membrane structures are formed using known methods, the components and steps may be appropriate for each production method, except that a phospholipid with an acid value of 5 mg KOH / g or more is included as a component constituting the lipid membrane structure. When using the composition for forming lipid membrane structures described above, a method in which a large excess of water is added to a composition for forming lipid membrane structures obtained by mixing the above-mentioned component (A) with, optionally, components (B) to (F) and other components, or a method in which the composition for forming lipid membrane structures is added to a large excess of water, may also be used. From the viewpoint of improving the dispersibility of lipid membrane structures, the latter method is preferred. That is, in the method for producing the lipid membrane structure-containing composition according to this embodiment, it is preferable to disperse the composition for forming lipid membrane structures obtained by mixing the above-mentioned component (A) with, optionally, components (B) to (F) and other components, in an aqueous phase.

[0065] More specifically, the method for producing a lipid membrane structure-containing composition in this embodiment preferably comprises a step of mixing the above-mentioned component (A) with one or more components selected from the group consisting of component (B), component (C), component (D), component (E), component (F), and other components as needed to obtain a composition for forming lipid membrane structures (mixing step), and a step of dispersing the composition for forming lipid membrane structures in an aqueous phase (dispersing step).

[0066] (Mixing process) In the mixing step, the components may be mixed all at once or sequentially. When the components are mixed sequentially, the order is not particularly limited. For example, when preparing a composition for forming lipid membrane structures using components (A), (B), and (C), components (A) and (B) may be mixed first, followed by addition of component (C), or components (A) and (C) may be mixed first, followed by addition of component (B), or components (B) and (C) may be added simultaneously to component (A) and mixed therewith (e.g., by adding a mixed solvent of components (B) and (C)). Furthermore, when preparing a composition for forming lipid membrane structures using components (C), (D), and / or (E) in addition to components (A) and (B), components (C), (D), and / or (E) may be added separately, or may be mixed in advance and then the resulting mixture added. Furthermore, for example, when preparing a composition for forming lipid membrane structures using the above-mentioned components (A), (B), and (F) as well as components (C), (D), and / or (E), the order of addition of component (F) is not particularly limited. For example, after mixing components (A), (B), and (F), components (C), (D), and / or (E) may be added simultaneously or sequentially. Alternatively, components (A) and (B) may be mixed simultaneously or sequentially with component (C), (D), and / or (E) added last. Furthermore, when preparing a composition for forming lipid membrane structures using the components described above in [Other Components], the order of addition of the components described above in [Other Components] is not particularly limited and can be selected appropriately depending on, for example, solubility. For example, if the component is lipid-soluble, it may be added together with component (F) or last. Alternatively, if it is water-soluble, it may be added when component (C), component (D) and / or component (E) are added, or may be added last.

[0067] The mixing temperature when mixing the components is not particularly limited, but is preferably equal to or higher than the phase transition temperature of component (A). For example, the upper limit is 120, 110, 100, 95, or 90°C, and the lower limit is 40, 45, 50, 55, 60, 65, 70, 75, 80, or 85°C. For example, it is 40 to 120°C, preferably 40 to 100°C, and more preferably 60 to 90°C. The mixing time is also not particularly limited, but is preferably 10 to 180 minutes. The mixing method is not particularly limited, but since it does not require high mechanical shearing force, it can be performed using known mixing means such as a magnetic stirrer (e.g., a hot stirrer), a paddle mixer, a propeller mixer, or a planetary mixer.

[0068] In the mixing step, in addition to the step of mixing the above-mentioned components, other steps such as purification (e.g., filtration), cooling, storage, etc. may be appropriately performed. For example, a mixture is prepared by mixing components (A) and (B) with, optionally, components (C) to (F) and some of the other components, and the undissolved matter contained in the mixture is removed by filtration. The mixture is then cooled and stored, and when preparing the lipid membrane structure-containing composition, the remaining components (B) to (F) and other components are blended with the mixture as necessary to obtain the composition for forming lipid membrane structures.

[0069] (Dispersion process) The dispersion of the composition for forming lipid membrane structures obtained by the mixing step into the aqueous phase may be carried out without stirring the aqueous phase (the composition for forming lipid membrane structures is added to the aqueous phase), or may be carried out while stirring the aqueous phase, or the aqueous phase may be added to the composition for forming lipid membrane structures. The stirring conditions for the aqueous phase and / or the composition for forming lipid membrane structures are not particularly limited, but may be carried out, for example, at a rotation speed of 10 to 300 rpm using a known stirring means. The composition for forming lipid membrane structures and / or the aqueous phase may be added all at once, in portions, or sequentially at any desired rate using a known dropwise addition means.

[0070] The aqueous phase preferably uses water with few impurities, such as purified water purified from tap water by a system that uses ion exchange, distillation, reverse osmosis, or ultrafiltration, either alone or in combination. Furthermore, the aqueous phase may further contain components other than water, as long as the lipid membrane structure can be formed. Examples of components other than water include oils, surfactants, moisturizers, whitening agents, coloring materials, alcohols, amino acids, sugars, vitamins, viscosity modifiers, polymers, colorants, powders, UV absorbers, preservatives, antibacterial agents, antioxidants, fragrances, cosmetic ingredients, electrolytes, fibers, and plant extracts.

[0071] In the dispersion step, the temperature of the aqueous phase is preferably equal to or higher than the phase transition temperature of component (A), since this tends to result in efficient formation of lipid membrane structures. The upper limit of the aqueous phase temperature is, for example, 100, 95, or 90°C, and the lower limit is 0, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, or 60°C. The temperature of the aqueous phase is, for example, 0 to 100°C, preferably 25 to 100°C, more preferably 40 to 95°C, and even more preferably 60 to 90°C.

[0072] In the dispersing step, the temperature of the composition for forming lipid membrane structures to be dispersed is preferably equal to or higher than the phase transition temperature of component (A), since this tends to result in efficient formation of lipid membrane structures. The upper limit of the temperature of the composition for forming lipid membrane structures is, for example, 120, 110, 100, 95, or 90°C, and the lower limit is 0, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, or 60°C. The temperature of the composition for forming lipid membrane structures is, for example, 0 to 120°C, preferably 25 to 120°C, more preferably 40 to 100°C, and even more preferably 60 to 90°C.

[0073] In the method for producing a lipid membrane structure-containing composition of this embodiment, in addition to the above-mentioned mixing and dispersing steps, other steps such as purification (for example, filtration), cooling, and storage may be further carried out.

[0074] <Scalp and hair improvement agent> The lipid membrane structure-containing composition of the present embodiment may be used as a scalp hair improving agent as it is, or the lipid membrane structure-containing composition may be incorporated into cosmetics or topical scalp hair preparations to impart a scalp hair improving effect.

[0075] The form of the scalp hair improvement agent of this embodiment is not particularly limited as long as the lipid membrane structures can be stably incorporated, and examples thereof include lotion, gel, emulsion, cream, shampoo, spray, etc. From the viewpoint of taking advantage of the transparent appearance, penetrating feel upon application, and high stability that are achieved by containing the fine lipid membrane structures of this embodiment (for example, having an average hydrodynamic diameter of 200 nm or less), it is preferable to incorporate the agent into a low-viscosity lotion, which is difficult to incorporate lipid membrane structures into.

[0076] In addition to the lipid membrane structure-containing composition, the scalp and hair improving agent of this embodiment may further contain ingredients that are commonly used in cosmetics or topical scalp and hair preparations, provided that the effects of the present invention are not impaired. Examples of such ingredients include, but are not limited to, oils, surfactants, moisturizers, whitening agents, coloring materials, alcohols, amino acids, vitamins, viscosity adjusters, polymers, colorants, powders, UV absorbers, preservatives, antibacterial agents, antioxidants, fragrances, cosmetic ingredients, electrolytes, pH adjusters, fibers, water, and plant extracts.

[0077] The concentration of the lipid membrane structures in the scalp and hair improving agent containing the lipid membrane structure-containing composition of this embodiment is preferably 0.0001% by mass or more, more preferably 0.01% by mass or more, and even more preferably 1% by mass or more. On the other hand, the upper limit of the concentration is not particularly limited, but is, for example, less than 5% by mass.

[0078] The scalp and hair improving effect is not particularly limited as long as it improves scalp and hair problems, and examples include one or more of the following: improving hair firmness, improving hair strength, improving hair gloss, improving hair moisture retention, improving hair frizz, preventing split ends, inhibiting color fading, preventing bedhead, eliminating bedhead, repairing the hair surface, improving scalp moisture retention, preventing scalp dandruff, improving scalp itching, inhibiting scalp inflammation, inhibiting scalp odor, hair growth effect, hair care effect, and reducing gray hair.

[0079] Furthermore, the scalp hair improvement effect includes either an immediate effect or a continuous effect, or both. An immediate effect refers to, for example, an effect that begins to appear 1 to 30 minutes, preferably 3 to 20 minutes, and more preferably 5 to 15 minutes after applying the scalp hair improvement agent to the scalp hair. A continuous effect refers to, for example, an effect that begins to appear 1 day to 1 month, preferably 3 days to 3 weeks, and more preferably 5 days to 2 weeks after continuing to apply the scalp hair improvement agent to the scalp hair twice a day, morning and night, and the effect is maintained or further enhanced as long as the application is continued thereafter. [Example]

[0080] The present invention will be explained in more detail using examples and comparative examples, but the present invention is not limited to these examples. In the following examples, unless otherwise specified, various operations were carried out at room temperature (20 to 25°C). Furthermore, unless otherwise specified, "%" and "parts" mean "% by mass" and "parts by mass," respectively.

[0081] <Preparation of lipid membrane structure-containing composition> A lipid membrane structure-containing composition was prepared by the following method. Lecithin was prepared by purchasing commercially available soybean-derived hydrogenated and non-hydrogenated lecithins with different acid values ​​(acid value 0.3 to 30.8 mg KOH / g) and mixing them in a ratio to obtain the desired acid value. The following six types of soybean-derived hydrogenated and non-hydrogenated lecithins were used: Hydrogenated lecithin acid value 0.3mgKOH / g Hydrogenated lecithin acid value 6.1mgKOH / g Hydrogenated lecithin Acid value 15.0mgKOH / g Hydrogenated lecithin Acid value 20.0mgKOH / g Hydrogenated lecithin Acid value 23.1mgKOH / g Non-hydrogenated lecithin Acid value 17.0mgKOH / g

[0082] [Examples 1 to 7, Comparative Examples 1 and 2] A composition for forming lipid membrane structures was obtained by heating components (A) to (F) (contents in parts by mass) shown in Table 1 to 80°C and mixing them uniformly. The composition for forming lipid membrane structures was added to component (G) heated to 80°C, mixed uniformly, and then cooled to obtain a composition containing lipid membrane structures. In Comparative Example 2, when components (A) to (F) were mixed, unmixed oil droplets were present, and a homogeneous solution was not obtained. Furthermore, the composition obtained by mixing this with the aqueous phase had a cloudy appearance, and the formation of lipid membrane structures could not be confirmed.

[0083] [exterior] The lipid membrane structure-containing compositions prepared in the Examples and Comparative Examples were visually observed for appearance at 25°C in a glass bottle with a diameter of 3.7 cm, and the appearance was evaluated based on the following criteria (a rating of ⊚ or ◯ indicates that the dispersibility of the lipid membrane structures is good): ◎: Transparent or semi-transparent liquid in which the text on the opposite side of the container can be seen ○: The letters on the other side of the container are not visible, but the liquid is homogeneous ×: Separation or precipitation is observed.

[0084] [Presence or absence of lipid membrane structure formation] The lipid membrane structure-containing compositions prepared in the Examples and Comparative Examples were subjected to Cryo-TEM observation using a transmission electron microscope (Hitachi High-Technologies Corporation, H-7650), and the presence or absence of lipid membrane structure formation was evaluated based on the following criteria (if ◎ or ○ is selected, it can be determined that lipid membrane structures have been formed): ◎: Unilamellar liposome structures and bicelle structures are observed ○: In addition to unilamellar liposome structures and bicelle structures, multilamellar liposome structures are observed. ×: No lipid membrane structure observed

[0085] [Mean hydrodynamic diameter, polydispersity index (PDI)] For the lipid membrane structure-containing composition prepared above, the average hydrodynamic diameter and polydispersity index (PDI) of the lipid membrane structures were measured by cumulant analysis using a dynamic light scattering measurement device (Zetasizer Nano ZSP, manufactured by Malvern Instruments).

[0086] Figure 1 shows a Cryo-TEM image of the lipid membrane structure-containing composition obtained in Example 5. The ring-shaped images indicate unilamellar liposome structures, and the rod-shaped images indicate bicelle structures, confirming the formation of unilamellar lipid membrane structures.

[0087] [Scalp and hair improvement effect test] The lipid membrane structure-containing compositions obtained in the examples and comparative examples were used as samples to carry out the following effect tests a to z by a panel of 20 experts (men and women in their 20s to 50s), and the effects compared to before the start of application were judged by sensory evaluation based on the following criteria. ◎: Very effective ○: Effective △: No change ×: Condition worsens a [Immediate improvement of hair firmness] Each sample was applied to hair, and the immediate effect of improving the firmness of the hair after drying was evaluated. b [Continuous improvement of hair firmness] Each sample was applied to hair twice a day, morning and evening, and the effect of continuously improving hair firmness was evaluated after one week. c [Immediate improvement of hair strength] Each sample was applied to hair, and the immediate effect of improving the body of the hair after drying was evaluated. d [Continuous improvement of hair strength] Each sample was applied to hair twice a day, morning and evening, and the effect of continuously improving hair strength was evaluated after one week. e[Immediate improvement of hair shine] Each sample was applied to hair, and the immediate effect of improving the shine of the hair after drying was evaluated. f [Continuous improvement of hair shine] Each sample was applied to hair twice a day, morning and evening, and the effect of continuously improving hair shine was evaluated after one week. g[Immediate improvement of hair shine] Each sample was applied to hair, and the immediate effect of improving the shine of the hair after drying was evaluated. h [Continuous improvement of hair gloss] Each sample was applied to hair twice a day, morning and evening, and the effect of continuously improving hair gloss was evaluated after one week. i [Immediate hair moisturizing effect] Each sample was applied to hair, and the immediate moisturizing effect on the hair after drying was evaluated. j [Continuous improvement of hair moisture] Each sample was applied to hair twice a day, morning and evening, and the continuous moisturizing effect on hair was evaluated after one week. k [Immediate improvement of hair frizz] Each sample was applied to hair, and the immediate effect of improving hair frizz after drying was evaluated. l [Continuous improvement of hair frizz] Each sample was applied to hair twice a day, morning and evening, and the effect of continuously improving hair frizz was evaluated after one week. m[Prevents split ends] Each sample was applied to hair twice a day, morning and evening, and the effectiveness in preventing split ends was evaluated for four weeks after the start of application. n [Color fade prevention effect] Each sample was applied to hair twice a day, morning and evening, and the effect of preventing color fading was evaluated for four weeks after the start of application. o [Prevents bedhead] Each sample was applied to hair, and the effectiveness in preventing bedhead the next morning was evaluated. p[Bedhead Removal] Each sample was applied to hair, and the effect of eliminating bedhead after drying was evaluated. q [Hair surface (cuticle) repair effect] Each sample was applied to hair, and the repair effect on the hair surface (cuticle) after drying was evaluated. [Immediate scalp moisturizing effect] After applying each sample to the scalp, the immediate moisturizing effect on the scalp was evaluated. [Continuous improvement of scalp moisture] Each sample was applied to the scalp twice a day, morning and evening, and the effect of continuously improving scalp moisture was evaluated after one week. t[Anti-dandruff effect on scalp] Each sample was applied to the scalp twice a day, morning and evening, and the effectiveness in preventing dandruff on the scalp was evaluated after one week. u[Scalp itching relief] Each sample was applied to the scalp twice a day, morning and evening, and the effect of improving scalp itching was evaluated after one week. v[Scalp inflammation suppression effect] Each sample was applied to the scalp twice a day, morning and evening, and the effect of suppressing scalp inflammation was evaluated after one week. w[Scalp odor improvement effect] Each sample was applied to the scalp twice a day, morning and evening, and the effect of improving scalp odor was evaluated after one week. x[Hair growth effect] Each sample was applied to the scalp twice a day, morning and evening, and the hair growth effect was evaluated for six months after the start of application. y[Hair growth effect] Each sample was applied to the scalp twice a day, morning and evening, and the hair growth effect was evaluated for six months after the start of application. z[Effective in reducing gray hair] Each sample was applied to the scalp twice a day, morning and evening, and the effectiveness in preventing gray hair was evaluated over a period of six months from the start of application.

[0088] The results of each of the above evaluations are shown in Table 1 below.

[0089] [Table 1]

[0090] As shown in Table 1, the compositions of Examples 1 to 7, in which lipid membrane structures formed from hydrogenated and non-hydrogenated lecithin with an acid value of 5 mg KOH / g or more were dispersed, exhibited scalp and hair-improving effects such as improving hair wrinkles and firmness, improving scalp moisture, and preventing scalp dandruff. On the other hand, Comparative Example 1 used hydrogenated lecithin with an acid value of less than 5 mg KOH / g, and although the formation of lipid membrane structures was confirmed, the scalp and hair-improving effect was insufficient. Comparative Example 2 used hydrogenated lecithin with an acid value of 5 mg KOH / g or more, but due to the incorporation of excessive squalane, an O / W emulsion was formed instead of a lipid membrane structure, and the scalp and hair-improving effect was insufficient.

Claims

1. A scalp and hair improving agent comprising a composition containing a lipid membrane structure formed from phospholipids having an acid value of 5 mg KOH / g or more.

2. The scalp and hair improving agent according to claim 1, wherein the phospholipid is a hydrogenated phospholipid.

3. The scalp hair improvement agent according to claim 1 or 2, wherein the lipid membrane structure is a single-layer lamellar structure.

4. The scalp and hair improvement agent according to claim 1 or 2, wherein the lipid membrane structures have an average hydrodynamic diameter of 200 nm or less.

5. The scalp and hair improvement agent according to claim 1 or 2, which has an effect of improving hair firmness.

6. The scalp and hair improving agent according to claim 1 or 2, which has an effect of improving hair stiffness.

7. The scalp and hair improving agent according to claim 1 or 2, which has an effect of improving hair gloss.

8. The scalp and hair improvement agent according to claim 1 or 2, which has a hair gloss improving effect.

9. The scalp and hair improvement agent according to claim 1 or 2, which has a hair moisturizing improving effect.

10. The scalp and hair improving agent according to claim 1 or 2, which has an effect of improving hair frizz.

11. The scalp and hair improving agent according to claim 1 or 2, which has a split end prevention effect.

12. The scalp and hair improving agent according to claim 1 or 2, which has an effect of suppressing color fading.

13. The scalp and hair improving agent according to claim 1 or 2, which has a bedhead preventing effect.

14. The scalp and hair improving agent according to claim 1 or 2, which has an effect of eliminating bedhead.

15. The scalp and hair improving agent according to claim 1 or 2, which has a hair surface repair effect.

16. The scalp and hair improvement agent according to claim 1 or 2, which has a scalp moisturizing improving effect.

17. The scalp and hair improving agent according to claim 1 or 2, which has a scalp dandruff prevention effect.

18. The scalp and hair improvement agent according to claim 1 or 2, which has an effect of improving scalp itching.

19. The scalp and hair improving agent according to claim 1 or 2, which has an effect of suppressing inflammation of the scalp.

20. The scalp and hair improving agent according to claim 1 or 2, which has a scalp odor suppressing effect.

21. The scalp and hair improving agent according to claim 1 or 2, which has a hair growth effect.

22. The scalp hair improving agent according to claim 1 or 2, which has a hair growth effect.

23. The scalp hair improving agent according to claim 1 or 2, which has an effect of improving gray hair.

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