New benzimidazole pyridine derivatives
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- F HOFFMANN LA ROCHE & CO AG
- Filing Date
- 2023-01-18
- Publication Date
- 2026-05-29
AI Technical Summary
The prior art has not yet effectively solved the role of SIK kinase in regulating immune cell function, especially in reducing inflammatory responses and promoting tissue repair, resulting in the lack of effective treatment methods for many diseases such as rheumatoid arthritis and inflammatory bowel disease.
A new class of SIK kinase inhibitor compounds have been developed to influence the phosphorylation status of CRTC and HDAC by regulating the activity of SIK kinases, thereby regulating the expression of cytokines such as IL-10 and TNF-α, reducing inflammatory responses and promoting tissue repair.
These compounds can effectively inhibit SIK kinase, increase IL-10 expression, reduce TNF-α and other inflammatory cytokines, and are used in the treatment of inflammatory diseases and tissue repair, with broad therapeutic potential.
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