Device and method for perfusing a target heart through the coronary sinus

Abstract

A device for perfusing the coronary sinus of a target heart, comprising a double-lumen catheter including a first lumen having a proximal opening and a distal opening configured to be disposed within the coronary sinus of the target heart, and a second lumen parallel to the first lumen, the second lumen having a proximal opening and a distal opening longitudinally offset from the distal opening of the first lumen toward the proximal opening of the second lumen, the distal opening of the second lumen being configured to be disposed within the right atrium of the target heart, and an oxygenator connected to the proximal openings of the first lumen and the second lumen, the oxygenator being configured to oxygenate deoxygenated blood.

Description

Technical Field

[0001] The present invention relates to the field of treating myocardial ischemia and coronary artery disease, and more particularly to devices and methods for perfusing a subject's heart via the venous system of the coronary sinus.

Background Art

[0002] Acute myocardial infarction occurs when blood flow to the coronary arteries of a subject's heart is reduced or stopped, for example, due to coronary artery stenosis, thrombosis, or plaque rupture. To treat coronary artery stenosis, the subject undergoes a percutaneous coronary intervention procedure in a catheterization laboratory, in which a balloon is inflated to reopen or increase blood flow and a stent is inserted through the stenosis or occlusion point of the coronary artery. Treatment of myocardial infarction is time-critical and must be performed within 60 - 90 minutes after the subject contacts a healthcare provider. However, in some cases, for example, due to complex coronary artery anatomy or high-risk coronary artery lesions, it may take longer to overcome significant occlusions and reopen or increase flow. Delays in treatment can cause myocardial ischemia, irreversible myocardial damage, or prolonged and potentially life-threatening cardiogenic shock. The prior art has not provided simple devices and methods that can perfuse a subject's heart in complex or high-risk situations and provide the cardiologist with the time necessary to perform optimal treatment for the patient.

Summary of the Invention

Means for Solving the Problems

[0003] Embodiments of the present invention are devices for perfusing the coronary sinus of a target heart, comprising a first lumen having a proximal opening and a distal opening configured to be disposed within the coronary sinus of the target heart, and a second lumen parallel to the first lumen, the second lumen having a proximal opening and a distal opening longitudinally offset from the distal opening of the first lumen towards the proximal opening of the second lumen, the distal opening of the second lumen being configured to be disposed within the right atrium of the target heart. The device may also include an oxygenator connected to the proximal openings of the first and second lumens, the oxygenator being configured to oxygenate deoxygenated blood. The distal opening of the second lumen may be offset from the distal opening of the first lumen by 4 to 8 cm, for example, to ensure that when the distal opening of the first lumen is disposed within the coronary sinus of the target heart, the distal opening of the second lumen is disposed within the right atrium of the target heart. The device may include a pump for driving deoxygenated blood from the right atrium through the second lumen of the catheter to the oxygenator and for driving oxygenated blood from the oxygenator through the first lumen of the catheter to the coronary sinus. The device may include an inflatable member disposed on an outer portion of the catheter in a region between the distal openings of the first and second lumens. The inflatable member may be offset from the distal opening of the first lumen by 1 to 3 cm, for example, to ensure that the inflatable member is disposed within the coronary sinus. The device may include a conduit configured to deliver pressurized fluid to the inflatable member to alternately inflate and deflate the inflatable member. The inflatable member may have a cross-sectional shape that occupies a portion of the cross-section of the coronary sinus when the inflatable member is inflated within the coronary sinus. The inflatable member may have a shape configured to occlude a portion smaller than the entire cross-section of the coronary sinus to ensure blood flow between the coronary sinus and the right atrium when the inflatable member is fully inflated within the coronary sinus. The inflatable member may have a shape configured to fix the catheter within the coronary sinus when the inflatable member is fully inflated within the coronary sinus.The device may include a pressure sensor disposed on an outer portion of the catheter in the region between the distal opening of the first lumen and the expandable member. The pressure sensor may measure the pressure within the coronary sinus. The measurement of the expansion of the expandable member may be determined based on a signal from the pressure sensor to control the pressure within the coronary sinus. The expandable member may fix the catheter within the coronary sinus when the expandable member is expanded within the coronary sinus. The expandable member may restrict the flow of blood from the coronary sinus to the right atrium of the subject's heart when the expandable member is expanded within the coronary sinus.

[0004] Embodiments of the present invention are methods of perfusing the coronary sinus of a subject's heart, comprising providing a double-lumen catheter, the catheter comprising a first lumen and a second lumen parallel to each other, wherein the distal opening of the second lumen is longitudinally offset (e.g., 4 to 8 cm) from the distal opening of the first lumen towards the proximal opening of the second lumen, inserting the catheter into the subject's heart, placing the distal opening of the first lumen within the coronary sinus of the subject's heart, and placing the distal opening of the second lumen within the right atrium of the subject's heart, driving deoxygenated blood from the right atrium through the second lumen of the catheter using a pump, oxygenating the deoxygenated blood using an oxygenator, and driving the oxygenated blood through the first lumen of the catheter to the coronary sinus using a pump. The catheter may be fixed within the coronary sinus using an expandable member disposed on an outer portion of the catheter in the region between the distal opening of the first lumen and the distal opening of the second lumen. The measurement of the expansion of the expandable member may control the pressure within the coronary sinus. The pressure within the coronary sinus may be measured using a pressure sensor disposed on an outer portion of the catheter in the region between the distal opening of the first lumen and the expandable member. The measurement of the expansion of the expandable member may be controlled based on a signal from the pressure sensor. The expandable member may be contracted and the catheter may be removed from the subject's heart.

[0005] To better understand the embodiments of the present invention and to show how the embodiments of the present invention may be implemented, reference is now made, by way of example only, to the accompanying drawings in which like reference numerals refer to corresponding elements or sections throughout.

Brief Description of the Drawings

[0006]

Figure 1A

Figure 1B

Figure 2

Figure 3

Modes for Carrying Out the Invention

[0007] It will be understood that, for simplicity and clarity of illustration, the elements shown in the drawings are not necessarily drawn to scale. For example, the dimensions of some elements may be exaggerated relative to other elements for clarity. Further, reference numerals may be repeated between the drawings to indicate corresponding or similar elements where appropriate.

[0008] In the following description, various aspects of the present invention are described. For the purposes of the description, specific configurations and details are set forth in order to provide a thorough understanding of the present invention. However, it will be apparent to those skilled in the art that the present invention may be practiced without these specific details. Further, well-known features are omitted or simplified in order not to obscure the present invention. Referring specifically to the drawings, the details shown are by way of example and are for purposes of discussion only to aid in the description of the present invention, and it is emphasized that they are presented to provide the most useful and readily understood description of the principles and conceptual aspects of the present invention. In this regard, the structural details of the present invention are not shown in more detail than is necessary for a basic understanding of the present invention, and the description, interpreted in conjunction with the drawings, will make apparent to those skilled in the art how some forms of the present invention may be embodied in practice.

[0009] Before detailing at least one embodiment of the present invention, it must be understood that the application of the present invention is not limited to the details of the construction and equipment of the components described or illustrated in the following description. The present invention is applicable to other embodiments that may be practiced or executed in various ways, as well as combinations of the disclosed embodiments. Also, it must be understood that the syntax and terminology utilized herein are for the purpose of description and should not be regarded as limiting.

[0010] Embodiments of the present invention provide a device for perfusing a subject's heart through the coronary sinus. The coronary sinus is a collection of veins that merge to form a large blood vessel and return deoxygenated blood from the myocardium to the right side of the heart so that the blood may be replenished with oxygen. The device may include a double-lumen catheter including a first lumen and a second lumen parallel to each other, and the distal opening of the second lumen is longitudinally offset from the distal opening of the first lumen toward the proximal opening of the second lumen. The catheter is configured such that when the catheter is inserted into the subject's heart, the distal opening of the first lumen is disposed within the coronary sinus of the subject's heart and the distal opening of the second lumen is disposed within the right atrium of the subject's heart. The device may include an oxygen supply for oxygenating deoxygenated (e.g., venous) blood. The oxygen supply may be connected to the proximal openings of the first lumen and the second lumen. The device may include a pump (which may be part of the oxygen supply, for example) for driving deoxygenated blood from the right atrium of the subject's heart through the second lumen of the catheter and driving oxygenated blood to the coronary sinus through the first lumen of the catheter. The device may include an inflatable member disposed on an outer portion of the catheter in a region between the distal opening of the first lumen and the distal opening of the second lumen. When inflated, the inflatable member may fix the catheter within the coronary sinus. When inflated, the inflatable member may occlude a portion of the cross-section of the coronary sinus to ensure that blood may flow between the coronary sinus and the right atrium of the subject's heart. The measurement of the inflation of the inflatable member may be determined to control the measurement of the occlusion of the cross-section of the coronary sinus by the inflatable member. The measurement of the inflation of the inflatable member and / or the flow rate of oxygenated blood to the coronary sinus may be determined to control the pressure within the coronary sinus of the subject's heart. The operation of the device is simple and may be easily performed by a cardiologist in cases of complex or high-risk situations of myocardial infarction that delay percutaneous coronary intervention procedures.By using this device to perfuse the target heart through the coronary sinus, the cardiologist may be provided with the time to select and perform the optimal treatment for myocardial infarction while eliminating (or at least reducing) the risk of causing prolonged myocardial ischemia, irreversible myocardial damage, and / or cardiogenic shock.

[0011] Next, refer to FIGS. 1A and 1B, which are schematic diagrams of a device 100 for perfusing the target heart through the coronary sinus according to some embodiments of the present invention.

[0012] The device 100 may include a catheter 110. The catheter 110 may be a double-lumen catheter. The catheter 110 may include a first lumen 112 and a second lumen 114. The first lumen 112 and the second lumen 114 may be parallel to each other along at least a portion of their lengths.

[0013] The first lumen 112 of the catheter 110 may have a proximal opening 112a and a distal opening 112c. The second lumen 114 of the catheter 110 may have a proximal opening 114a and a distal opening 114c. The distal opening 114c of the second lumen 114 may be offset or spaced from the distal opening 112c of the first lumen 112 in the longitudinal direction 110a of the catheter 110, towards the proximal opening 114a of the second lumen 114. For example, the distal opening 114c of the second lumen 114 may be offset or spaced 4 to 8 cm, such as 5 cm, from the distal opening 112c of the first lumen 112. The length of the first lumen 112 may be in the range of, for example, 50 to 70 cm, such as 60 cm. The length of the second lumen 114 may be in the range of, for example, 40 to 60 cm, such as 55 cm. These dimensions may enable, for example, the insertion of the catheter 110 into the target heart through the right internal jugular vein of the target's neck, the placement of the distal opening 112c of the first lumen 112 within the coronary sinus of the target heart, the placement of the distal opening 114c of the second lumen 114 within the right atrium of the target heart, and may further enable the manipulation of the catheter 110 and the connection to an oxygen supply device 130 (as described later, for example).

[0014] Device 100 may include an inflatable (e.g., expandable) member (e.g., an inflatable balloon) 120. FIGS. 1A and 1B respectively show the inflated member 120 in a contracted state and an inflated state. The inflatable member 120 may be disposed or connected to an outer portion of the catheter 110 in a region 110c between, for example, the distal opening 112c of the first lumen 112 of the catheter 110 and the distal opening 114c of the second lumen 114. For example, the inflatable member 120 may be offset or spaced 1 to 3 cm, e.g., 2 cm, from the distal opening 112c of the first lumen 112. By offsetting the inflatable member 120 1 to 3 cm (e.g., 2 cm) from the distal opening 112c of the first lumen 112, the placement of the inflatable member 120 within the coronary sinus may be ensured. Device 100 may include a conduit 124 for delivering pressurized fluid between the inflatable member 120 to alternately inflate or deflate the inflatable member 120. When inflated (e.g., fully inflated), the inflatable member 120 may have a transverse shape that occludes a portion (e.g., a portion smaller than the entire cross-section) of the cross-section of the coronary sinus of the target heart. The inflatable member 120 may have a transverse shape that prevents the inflatable member 120 from occluding the entire cross-section of the coronary sinus of the target heart when the inflatable member 120 is inflated (e.g., fully inflated) within the coronary sinus. The inflatable member 120 may have a shape that occludes a portion smaller than the entire cross-section of the coronary sinus to ensure blood flow between the coronary sinus and the right atrium when the inflatable member 120 is inflated (e.g., fully inflated) within the coronary sinus. The inflatable member 120 may have a shape that fixes the catheter 110 within the coronary sinus when the inflatable member 120 is inflated (e.g., fully inflated) within the coronary sinus. When inflated (e.g., fully inflated), the inflatable member 120 may have, for example, a non-circular transverse shape. For example, when inflated (e.g., fully inflated), the inflatable member 120 may have four lobes 122 that project radially outward from the catheter 110 (e.g., as shown in FIG. 1B). Other examples of the transverse shape of the inflatable member 120 in the inflated (e.g., fully inflated) state may include a triangular or quadrilateral (e.g., rhombus) shape.The expandable member 120 may have other transverse shapes.

[0015] The device 100 may include a pressure sensor 126. The pressure sensor 126 may be disposed or connected to an outer portion of the catheter 110 in a region 110e, for example, between the distal opening 112c of the first lumen 110 and the expandable member 120. The pressure sensor 126 may measure the pressure within the coronary sinus of the target heart.

[0016] The device 100 may include an oxygen supply 130. The oxygen supply 130 may be connected to the proximal openings 112a, 114a of the first lumen 112 and the second lumen 114, respectively (as schematically shown, for example, by the arced arrows in FIGS. 1A and 1B). The oxygen supply 130 may include a pump 132. The oxygen supply 130 may receive deoxygenated (e.g., venous) blood. The oxygenation device 130 may oxygenate the deoxygenated blood.

[0017] Next, reference is made to FIG. 2, which is a schematic diagram of a device 100 for perfusing a target heart 90 via the target heart 90 and coronary sinus 92 according to some embodiments of the present invention.

[0018] As schematically shown in FIG. 2, the coronary sinus 92 is a collection of myocardial veins that merge to form a large blood vessel that returns deoxygenated blood from the myocardium to the right atrium 94 of the heart 90 so that the blood may be oxygenated.

[0019] During operation, the catheter 110 of the device 100 is inserted into the heart 90 of the subject through, for example, the right internal jugular vein or any other suitable blood vessel known in the art, such that the distal opening 112c of the first lumen 112 is disposed within the coronary sinus 92 and the distal opening 114c of the second lumen 114 is disposed within the right atrium 94 of the heart 90 of the subject. Pressurized fluid may be delivered through the conduit 124 to the inflatable member 120 to cause the inflatable member 120 to expand. Upon inflation, the inflatable member 120 may fix the catheter 110 within the coronary sinus 92 (as shown, for example, in FIG. 2). Upon inflation, the cross-sectional shape of the inflatable member 120 occludes only a portion of the cross-section of the coronary sinus 92 (as shown, for example, in FIG. 2), such that blood flow between the coronary sinus 92 and the right atrium 94 of the heart 90 of the subject is ensured, for example, to avoid over-inflation and pressure of the coronary sinus.

[0020] When the catheter 110 is disposed within the heart 90 of the subject (as described above and schematically shown in FIG. 2), the device 100 is configured such that the pump 132 drives deoxygenated (e.g., venous) blood from the right atrium 94 of the heart 90 of the subject through the second lumen 114 of the catheter 110 to the oxygenator 130. The oxygenator 130 may receive deoxygenated blood from the second lumen 114 of the catheter 110 and oxygenate the deoxygenated blood. The pump 132 may drive the oxygenated blood from the oxygenator 130 through the first lumen 112 of the catheter 110 to the coronary sinus 92 of the heart 90 of the subject. The oxygenated blood received within the coronary sinus 92 may perfuse the heart 90 of the subject by transporting oxygen into the tissue of the heart 90 of the subject.

[0021] Measurement of the expansion of the expandable member 120 and / or the flow rate of oxygenated blood through the first lumen 112 into the coronary sinus 92 may be determined to control the pressure within the coronary sinus 92 of the subject's heart 90. For example, a pressure sensor 126 may measure the pressure within the coronary sinus 92, and based on the measured pressure, the expansion of the expandable member 120 and / or the measurement of the flow rate of oxygenated blood into the coronary sinus 92 may be determined. For example, a pressure that is too high within the coronary sinus 92 (e.g., a pressure exceeding a specified threshold) may indicate that the expandable member 120 is over-expanded, occluding too large a portion of the cross-section of the coronary sinus 92, and thus overly restricting blood flow between the coronary sinus 92 and the right atrium 94. In this case, the expandable member 120 may be contracted by removing pressurized fluid from the expandable member 120 through the conduit 124 until the pressure within the coronary sinus 92 measured by the pressure sensor 126 reaches a desired pressure value. Control of the expansion and contraction of the expandable member 120 based on signals from the pressure sensor 126 and / or control of the flow rate of oxygenated blood into the coronary sinus 92 may be performed, for example, by a cardiologist performing the procedure. In various embodiments, the device 100 may include a controller 140 (e.g., shown as a dashed rectangle in FIG. 2) that controls the delivery of pressurized fluid to the expandable member 120 based on signals from the pressure sensor 126 and / or controls the flow rate of oxygenated blood into the coronary sinus 92.

[0022] The expanded expandable member 120 may restrict blood flow between the coronary sinus 92 and the right atrium 94 of the subject's heart 90, thus ensuring that oxygenated blood remains within the coronary sinus 92 for a sufficiently long time (e.g., or at least longer than in the absence of the expandable member 120), enhancing the perfusion effect. Other devices, such as a reducer stent, configured to reduce or restrict blood flow between the coronary sinus 92 and the right atrium 94 of the subject's heart 90 during the procedure may be used instead of or in addition to the expandable member 120.

[0023] The insertion and operation of device 100 are simple and may be easily performed by a cardiologist in the case of a complex or high-risk situation of myocardial infarction that delays percutaneous coronary intervention procedures. By perfusing the target heart 90 through the coronary sinus 92 using device 100, the cardiologist may be provided with time to select and perform optimal treatment for myocardial infarction while eliminating (or at least reducing) the risk of causing prolonged myocardial ischemia, myocardial injury, and / or cardiogenic shock.

[0024] When the procedure (e.g., myocardial infarction treatment) is completed, the inflatable member 120 may be contracted and the catheter 110 may be removed from the target heart 90.

[0025] Next, refer to FIG. 3, which is a flowchart of a method for perfusing a target heart through the coronary sinus according to some embodiments of the present invention.

[0026] The operations of FIG. 3 may be performed using the devices shown in FIGS. 1A - 1B and FIG. 2, but may also be performed using other devices.

[0027] In operation 302, a double-lumen catheter is inserted into the target heart (as described above with respect to FIG. 2, for example), the distal opening of the first lumen of the catheter is disposed within the coronary sinus of the target heart, and the distal opening of the second lumen of the catheter is disposed within the right atrium of the target heart. For example, the catheter may be the catheter 110 described above with respect to FIGS. 1A - 1B and FIG. 2. As described above with respect to FIGS. 1A - 1B and FIG. 2, the catheter 110 may include a first lumen 112 and a second lumen 114 that are parallel to each other, and the distal opening 114c of the second lumen 114 is offset or spaced from the distal opening 112c of the first lumen 112 in the longitudinal direction 110a of the catheter 110 toward the proximal opening 114a of the second lumen 114. The insertion of the catheter into the target heart is simple and may be easily performed by a cardiologist (as described above with respect to FIG. 2, for example).

[0028] In operation 304, the deoxygenated (e.g., venous) blood may be driven by a pump (e.g., the pump 132 described above with respect to FIGS. 1A-1B and FIG. 2) from the right atrium of the subject's heart through the second lumen of the catheter to an oxygenator (e.g., the oxygenator 130 described above with respect to FIGS. 1A-1B and FIG. 2). In operation 306, the deoxygenated blood may be oxygenated using the oxygenator (as described above with respect to FIGS. 1A-1B and FIG. 2). In operation 308, the oxygenated blood may be driven by the pump from the oxygenator through the first lumen of the catheter to the coronary sinus of the subject's heart.

[0029] The catheter may include an inflatable member (e.g., the inflatable member 120 described above with respect to FIGS. 1A-1B and FIG. 2) disposed or connected to an outer portion of the catheter in a region between the distal opening of the first lumen and the distal opening of the second lumen. During operation, the inflatable member may be inflated to fix the catheter within the coronary sinus. The measurement of the inflation of the inflatable member may be controlled to control the pressure within the coronary sinus (as described above with respect to FIG. 2). The pressure within the coronary sinus may be measured by a pressure sensor (e.g., the pressure sensor 126 described above with respect to FIGS. 1A-1B and FIG. 2). The inflation and contraction of the inflatable member may be controlled based on a signal from the pressure sensor. For example, the inflation and contraction of the inflatable member may be controlled by a cardiologist and / or a controller (e.g., the controller 140 described above with respect to FIG. 2).

[0030] When the treatment is complete, the inflatable member may be deflated and the catheter removed from the subject's heart.

[0031] The operations described with respect to FIG. 3 are simple and may be easily performed by a cardiologist in the case of a complex or high-risk situation of myocardial infarction that delays percutaneous coronary intervention procedures. By perfusing the subject's heart through the coronary sinus as described with respect to FIG. 3, the cardiologist may be provided with time to select and perform an optimal treatment for myocardial infarction while eliminating (or at least reducing) the risk of causing prolonged myocardial ischemia, myocardial injury, and / or cardiogenic shock in the subject's heart.

[0032] In the above description, an embodiment is an example or implementation mode of the present invention. Various occurrences of "one embodiment", "an embodiment", "a certain embodiment", or "some embodiments" do not necessarily all refer to the same embodiment. Although various features of the present invention may be described in the context of a single embodiment, these features may also be provided separately or in any suitable combination. Conversely, although the present invention may be described in the context of separate embodiments for clarity in this specification, the present invention may also be implemented in a single embodiment. Certain embodiments of the present invention may include features from different embodiments disclosed above, and certain embodiments may incorporate elements from other embodiments disclosed above. The disclosure of elements of the present invention in the context of specific embodiments should not be construed as limiting their use to only those specific embodiments. Furthermore, it should be understood that the present invention can be implemented or practiced in various ways and that the present invention may be implemented in certain embodiments other than those outlined in the above description.

[0033] The present invention is not limited to these diagrams or corresponding descriptions. For example, the flow need not move through each box or state shown, or in exactly the same order as shown and described. The meanings of the technical and scientific terms used herein shall be generally understood by those skilled in the art to which the present invention pertains, unless otherwise defined. Although the present invention has been described with respect to a limited number of embodiments, these shall not be construed as limitations on the scope of the present invention, but rather as some examples of preferred embodiments. Other possible variations, modifications, and applications are also within the scope of the present invention. Therefore, the scope of the present invention shall not be limited by the content described above, but rather by the appended claims and their legal equivalents.

Claims

1. A device for perfusing the coronary sinus of a target heart, The device comprises a double-lumen catheter and an oxygenator, The double-lumen catheter, has a first lumen having a proximal opening and a distal opening configured to be disposed within the coronary sinus of the target heart, A second lumen parallel to the first lumen, the second lumen having a proximal opening and a distal opening longitudinally offset from the distal opening of the first lumen towards the proximal opening of the second lumen, the distal opening of the second lumen being configured to be disposed within the right atrium of the target heart, and an expandable member disposed on an outer portion of the catheter in a region between the distal opening of the first lumen and the distal opening of the second lumen, The expandable member has a shape configured to occlude a portion smaller than the entire cross-section of the coronary sinus to ensure blood flow between the coronary sinus and the right atrium when the expandable member is fully expanded within the coronary sinus, and the shape of the expandable member is also configured to fix the catheter within the coronary sinus when the expandable member is fully expanded within the coronary sinus, The oxygenator is a device connected to the proximal openings of the first lumen and the second lumen and configured to oxygenate deoxygenated blood.

2. The device according to claim 1, wherein the distal opening of the second lumen is offset 4 to 8 cm from the distal opening of the first lumen to ensure that the distal opening of the second lumen is disposed within the right atrium of the target heart when the distal opening of the first lumen is disposed within the coronary sinus of the target heart.

3. The device according to any one of claims 1 to 2, comprising a pump for driving the deoxygenated blood from the right atrium to the oxygenator through the second lumen of the catheter and driving the oxygenated blood from the oxygenator to the coronary sinus through the first lumen of the catheter.

4. The device according to any one of claims 1 to 3, wherein the expandable member is offset 1 to 3 cm from the distal opening of the first lumen to ensure that the expandable member is disposed within the coronary sinus.

5. The device according to any one of claims 1 to 4, comprising a conduit configured to deliver pressurized fluid to the expandable member to alternately expand and contract the expandable member.

6. The device according to any one of claims 1 to 5, comprising a pressure sensor disposed on the outer portion of the catheter in the region between the distal opening of the first lumen and the expandable member, the pressure sensor measuring the pressure within the coronary sinus.

7. The device according to claim 6, wherein the measurement of the expansion of the expandable member is determined based on a signal from the pressure sensor to control the pressure within the coronary sinus.

8. The device according to any one of claims 1 to 7, wherein the expandable member restricts the flow of blood from the coronary sinus to the right atrium of the subject's heart when the expandable member is expanded within the coronary sinus.

9. A method of perfusing the coronary sinus of a subject's heart, comprising: providing a double-lumen catheter, the catheter comprising: A first lumen and a second lumen parallel to each other, wherein a distal opening of the second lumen is longitudinally offset by a distance of 4 to 8 cm from a distal opening of the first lumen toward a proximal opening of the second lumen, the method comprising steps of providing the first lumen and the second lumen; Inserting the catheter into a target heart, disposing the distal opening of the first lumen within a coronary sinus of the target heart, and disposing the distal opening of the second lumen within a right atrium of the target heart; Driving deoxygenated blood from the right atrium through the second lumen of the catheter using a pump; Oxygenating the deoxygenated blood using an oxygenator; Driving the oxygenated blood to the coronary sinus through the first lumen of the catheter using the pump; A method comprising the steps above. **Claim 10** The method according to claim 9, further comprising fixing the catheter within the coronary sinus using an inflatable member disposed on an outer portion of the catheter in a region between the distal opening of the first lumen and the distal opening of the second lumen. **Claim 11** The method according to any one of claims 9 to 10, further comprising controlling measurement of inflation of the inflatable member to control pressure within the coronary sinus using an inflatable member disposed on an outer portion of the catheter in a region between the distal opening of the first lumen and the distal opening of the second lumen. **Claim 12** The method according to any one of claims 9 to 11, further comprising measuring pressure within the coronary sinus using a pressure sensor disposed on an outer portion of the catheter in a region between the distal opening of the first lumen and the inflatable member. **Claim 13** The method according to claim 12, further comprising controlling measurement of inflation of the inflatable member based on a signal from the pressure sensor.

14. The step of contracting the expandable member; The step of removing the catheter from the target heart; The method according to any one of claims 9 to 13, further comprising.

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