A stamp-type drug delivery device capable of delivering high doses of drugs

Abstract

The device is characterized by including a needle portion having a predetermined area and provided with a plurality of microneedles to be inserted into the user's skin, an elastic recovery portion that elastically contacts the needle portion, a cartridge that provides a space in which the needle portion and the elastic recovery portion can be accommodated and that forms a plurality of slit-shaped openings, and a body that is connected to the cartridge and descends due to force transmitted from the user to apply pressure to the elastic recovery portion.

Description

[Technical Field]

[0001] The present invention relates to a stamp-type drug delivery device capable of delivering high doses of drugs, and more particularly to a stamp-type drug delivery device configured to easily and effectively deliver high doses of active ingredients or drugs to the user's skin while also increasing the skin absorption rate. [Background technology]

[0002] Generally, methods for delivering active ingredients or drugs into the body include taking the drug orally, injecting the drug via injection, or absorbing the drug through the skin.

[0003] Among these methods, oral administration, i.e., taking drugs orally, may cause central nervous system side effects such as headache, drowsiness, dizziness, and nervousness, as well as serious gastrointestinal side effects such as nausea, dyspepsia, diarrhea, peptic ulcers, gastrointestinal bleeding, and gastrointestinal perforation, and is therefore limited to short-term therapy.

[0004] In addition, the method of injecting drugs via injection allows for fast absorption because a needle is inserted through the skin and the drug is injected directly into the body, but it is cumbersome as it must be administered only by a specialist (making self-administration difficult), and since a needle with a diameter of several millimeters is usually used, patients are not likely to tolerate it well due to the pain caused by the injection.

[0005] In order to eliminate the above-mentioned side effects and crystals, active efforts have been made to develop transdermal drug delivery systems.

[0006] Drugs that are absorbed through the skin are usually formulated in the form of liquids, creams, gels, etc. However, liquids, creams, and gels have problems such as difficulty in dosage control due to their formulation characteristics, stickiness, and contamination of the coating. Furthermore, most drugs are absorbed only in very small amounts and evaporate almost completely.

[0007] Therefore, a method of delivering a drug subcutaneously by attaching a patch containing an active ingredient or drug to the skin is used.

[0008] The patch method allows drugs to be absorbed through the skin, preventing side effects caused by taking drugs, such as gastrointestinal disorders and food-related effects, while still eliminating the pain and inconvenience of injections. Due to its convenience, the patch method has been increasingly used recently.

[0009] However, patch-based methods have the problem of low drug absorption through the skin. That is, a major drawback of patches is that the low drug absorption rate through the skin requires reducing the skin's function as a permeability barrier. Generally, the drug absorption rate through patches is known to be about 20%. To date, methods to improve absorption rate include chemical methods such as the use of skin absorption enhancers and precursor drugs, and physical methods such as iontophoresis and electrophoresis.

[0010] However, even when these known methods are used, there is still a limit to how much the drug absorption rate can be improved to a satisfactory level, and therefore, in order to expect the drug's efficacy, it is unavoidable to use an excess of the drug in consideration of the absorption rate.

[0011] In particular, the type of skin absorption enhancer is determined depending on the design type of the formulation to be used or the physicochemical properties of the components, and a certain concentration level or higher is required to be effective. However, when a skin absorption enhancer is added, it is difficult to prevent crystal formation over time, and adhesive properties such as adhesive strength and cohesive strength change to an extent that they are unsuitable for use.

[0012] In addition, technology that uses electricity requires the patch to have a battery, electrodes, circuits, and other components, which not only makes the product structure complex, large in size, and expensive, but also generates a large amount of waste after use.

[0013] As a result, fused polymer microneedles loaded with active ingredients or drugs have been developed to increase the skin absorption rate of active ingredients or drugs. However, the amount of drug loaded is small, and the skin penetration efficiency of the microneedles is reduced due to the strength limitations of the polymer. Furthermore, when attached to the skin, the microneedles may break if attached to an inclined surface rather than vertically, which makes commercialization difficult.

[0014] To solve this problem, a method has been proposed in which a plurality of microneedles are formed and arranged on a thin, bioabsorbable metal plate containing ingredients beneficial to the human body, and then the plate is attached to the skin.

[0015] However, there is a problem in that it is difficult to form and arrange the microneedles on a limited plane of a metal plate under the condition of maximizing the delivery effect of an active ingredient or drug.

[0016] Another problem is that the metal plate attached to the skin can easily come off due to the user's movements. Therefore, an adhesive patch was devised to prevent the metal plate from coming off the skin, but this has the disadvantage of causing a psychological resistance to the user because the adhesive patch and metal plate must be in close contact with the skin for a certain period of time.

[0017] Furthermore, in the case of microneedles, they are formed from a very thin metal plate, and therefore have the problem of easily breaking or bending when inserted into the skin.

[0018] Therefore, the present applicant has developed the present invention to solve such problems. Related prior art documents include Patent Document 1: U.S. Patent Publication No. 2007-0293815 entitled "Microprojection array application with sculptured microprojections for high drug loading." [Prior art documents] [Patent documents]

[0019] [Patent Document 1] U.S. Patent Publication No. 2007-0293815 Summary of the Invention [Problem to be solved by the invention]

[0020] The present invention is intended to solve the above-mentioned problems, and its purpose is to provide a structure that prevents multiple microneedles formed on a metal plate from breaking or deforming when inserted into the skin, and to provide a stamp-type drug delivery device that is configured to apply additional pressure after the microneedles are inserted so that the active ingredient or drug is delivered to the skin by riding on the microneedles.

[0021] Another object of the present invention is to provide a stamp-type drug delivery device that is configured to effectively deliver active ingredients or drugs subcutaneously to a user without having to attach a metal plate with microneedles formed on it to the user's skin for a certain period of time, and in particular to be able to deliver high doses of active ingredients or drugs.

[0022] Another object of the present invention is to provide a stamp-type drug delivery device that is configured to maximize the density of microneedles arranged and formed within a limited planar area of ​​a metal plate, thereby enabling effective delivery of active ingredients or drugs. [Means for solving the problem]

[0023] The present invention can provide a stamp-type drug capture device capable of delivering high doses of drugs, which includes a needle portion having a predetermined area and provided with a plurality of microneedles to be inserted into the user's skin, an elastic recovery portion that elastically contacts the needle portion, a cartridge that provides a space capable of accommodating the needle portion and the elastic recovery portion and has a plurality of openings formed in its bottom, and a body that is connected to the cartridge and pressurizes the elastic recovery portion with force transmitted from the user.

[0024] The needle portion may include a first needle sheet, a first protruding piece formed by cutting open a portion of the area of ​​the first needle sheet and protruding toward the opening of the cartridge, and a plurality of microneedles provided at the tip of the first protruding piece.

[0025] Furthermore, when the multiple microneedles provided on the first protruding piece are inserted into the user's skin, the first protruding piece and the microneedles formed on the first protruding piece can be supported by contacting one side surface that defines the opening of the cartridge.

[0026] In addition, the elastic restoring portion may include a first restoring means that is stacked on top of the first needle seat and pressed against the body, and a second restoring means that is arranged below the first needle seat and elastically supports the bottom of the first needle seat.

[0027] The first restoring means may include a first restoring sheet having openings corresponding to the incisions formed in the first needle sheet, and a plurality of first elastic members formed by incising a portion of the area of ​​the first restoring sheet and bent upward at a predetermined angle to elastically contact the bottom of the body.

[0028] The second restoring means may also include a second restoring sheet arranged on the bottom surface of the cartridge and having openings formed therein corresponding to the cut openings formed in the first needle sheet, and a plurality of second elastic members formed by cutting open a portion of the area of ​​the second restoring sheet and bent upward at a predetermined angle to elastically contact the bottom of the first needle sheet.

[0029] The second elastic members may have elastic force or rigidity smaller than that of the first elastic members, or may be provided on the second restoring sheet in a number smaller than that of the first elastic members.

[0030] The body may also include a storage space in which an active ingredient or drug is stored, a guide flow path that is communicatively connected to the storage space and through which the active ingredient or drug stored in the storage space flows, and a discharge member that guides the active ingredient or drug flowing along the guide flow path to an opening of the cartridge.

[0031] The body may further include a connector, one side of which is connected to the upper end of the body and the other side of which is connected to a reservoir in which an active ingredient or drug is stored.

[0032] The needle portion may include a second needle sheet overlapping the first needle sheet, a second protruding piece formed by cutting out a portion of the area of ​​the second needle sheet and protruding toward the opening of the cartridge, and a plurality of microneedles provided at the tip of the second protruding piece, and the second protruding piece may be arranged at a predetermined distance from the first protruding piece.

[0033] Furthermore, when the multiple microneedles provided on the second protruding piece are inserted into the user's skin, the second protruding piece and the microneedles formed on the second protruding piece can be supported by contacting the other side that defines the opening of the cartridge.

[0034] Furthermore, when the second needle sheet is stacked on the upper surface of the first needle sheet, the second protruding piece is positioned at a predetermined distance from the first protruding piece while passing through the cutout formed in the first sheet, and when the first needle sheet is stacked on the upper surface of the second needle sheet, the first protruding piece is positioned at a predetermined distance from the second protruding piece while passing through the cutout formed in the second needle sheet.

[0035] In addition, the microneedles of the needle part may have slits formed therein through which the active ingredient or drug can be carried and flowed. [Effects of the Invention]

[0036] In one embodiment of the present invention, a stamp-type drug delivery device capable of delivering high doses of drugs has a structure in which, when multiple microneedles formed on a thin metal plate are inserted into the skin, the first protruding piece or the second protruding piece supporting the microneedles is supported on the inner wall surface that defines the opening of the cartridge, or is supported by the discharge member of the body that descends to discharge the active ingredient or drug, thereby preventing the microneedles from breaking or deforming.

[0037] In addition, the stamp-type drug delivery device capable of delivering high doses of drugs according to one embodiment of the present invention provides a structure that prevents multiple microneedles inserted into the skin from breaking or deforming due to external forces, so that multiple microneedles can be manufactured using thin metal plates, improving manufacturing convenience and reducing manufacturing costs.

[0038] In addition, the stamp-type drug delivery device capable of high-dose drug delivery according to one embodiment of the present invention provides a configuration in which microneedles arranged at high density within a limited area are preferentially inserted into the skin, thereby easily delivering active ingredients or drugs subcutaneously through the microneedles and stimulating the skin to provide beneficial effects.

[0039] In addition, the stamp-type drug delivery device capable of delivering high doses of drugs according to one embodiment of the present invention can preferentially insert microneedles into the user's skin using a first force from the user, and deliver a high dose of active ingredient or drug to the skin site where the microneedles are inserted using a second force from the user, thereby increasing the skin absorption rate of the active ingredient or drug.

[0040] In addition, the stamp-type drug delivery device capable of delivering high doses of drugs according to one embodiment of the present invention contains microneedles inserted into the skin that contain bioabsorbable metal components that provide beneficial effects to the skin, so that it can provide not only skin stimulation and drug delivery effects, but also swelling effects and drug delivery enhancer functions subcutaneously.

[0041] In addition, the stamp-type drug delivery device capable of delivering high doses of drugs according to one embodiment of the present invention also provides a structure that allows the microneedles inserted into the skin to be easily replaced according to the user's needs, thereby preventing infection and allowing for semi-permanent use. [Brief explanation of the drawings]

[0042] [Figure 1] 1 is a perspective view of a stamp-type drug delivery device according to one embodiment of the present invention. [Figure 2] 1 is an exploded perspective view of a stamp-type drug delivery device according to one embodiment of the present invention; FIG. [Figure 3] 1 is a cross-sectional view of a stamp-type drug delivery device according to one embodiment of the present invention. [Figure 4] FIG. 2 is a perspective view of the configuration of a needle portion according to an embodiment of the present invention, as viewed from below. [Figure 5] 10 is a perspective view of a state in which a first needle seat and a second needle seat of a needle portion overlap each other, as viewed from below. FIG. [Figure 6] FIG. 2 is a perspective view showing the configuration of an elastic recovery portion according to an embodiment of the present invention. [Figure 7] 7 is a perspective view showing a state in which the first restoring means shown in FIG. 6 is disposed on the upper surface of the second needle seat, and the second restoring means is disposed below the first needle seat. FIG. [Figure 8] 8 is a side view of the elastic recovery portion and the needle portion shown in FIG. 7. FIG. [Figure 9] FIG. 2 is a perspective view of a body according to an embodiment of the present invention. [Figure 10] 9 is a side view showing a state in which a body is placed on the first elastic member shown in FIG. 8. FIG. [Figure 11] 10 is a perspective view showing a state in which a needle portion and an elastic restoring portion are housed in an inner space of a cartridge according to an embodiment of the present invention. FIG. [Figure 12] 12 is a perspective view showing a state in which a body is placed on top of the elastic recovery portion shown in FIG. 11. FIG. [Figure 13] FIG. 13 is a perspective view of the cartridge shown in FIG. 12 as seen from below. [Figure 14] FIG. 1 is a close-up view of a microneedle according to one embodiment of the present invention. [Figure 15] FIG. 1 is a perspective view of a stamp-type drug delivery device according to another embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0043] The advantages and features of the present invention and the methods for achieving them will become apparent from the following detailed description of the embodiments in conjunction with the accompanying drawings.

[0044] However, the present invention is not limited to the embodiments disclosed below, and may be realized in various different forms. However, the present embodiments are provided to complete the disclosure of the present invention and to fully convey the scope of the invention to those skilled in the art to which the present invention pertains, and the present invention is defined only by the scope of the claims.

[0045] A stamp-type drug delivery device capable of delivering a high dose of a drug according to one embodiment of the present invention will be described in detail below with reference to Figures 1 to 15. In describing the present invention, detailed descriptions of related known functions or configurations will be omitted to avoid obscuring the gist of the invention.

[0046] As shown in Figures 1 to 3, a stamp-type drug delivery device 100 according to one embodiment of the present invention includes a needle portion 110 having a predetermined area and provided with a plurality of microneedles 111d, 113d (see Figure 4) to be inserted into a user's skin, an elastic recovery portion 130 in elastic contact with the needle portion 110, a cartridge 150 providing a space for accommodating the needle portion 110 and the elastic recovery portion 130 and having a plurality of slit-shaped openings 151 formed in its bottom, and a body 170 detachably coupled to the cartridge 150, which descends by a force transmitted from a user to pressurize the elastic recovery portion 130 and provide a space through which an active ingredient or drug can pass to be delivered to the user's skin.

[0047] First, the needle portion 110 may be configured to include a plurality of needle seats 111a, 113a as shown in FIGS.

[0048] For reference, in one embodiment of the present invention, the needle portion 110 is shown in the drawings to include a first needle seat 111a and a second needle seat 113a. The first needle sheet 111a is a component incorporated into the inner space of the cartridge 150, and as shown in FIG. 4, is configured to include first protruding pieces 111c and microneedles 111d.

[0049] The first protruding piece 111c can be said to be a component formed by cutting out a part of the area of ​​the first needle seat 111a, that is, by cutting out a part of the area of ​​the first needle seat 111a and then bending it in one direction.

[0050] Therefore, the first needle seat 111a has a cutout 111b formed therein to form the first protruding piece 111c. The cutout 111b may have a position and size corresponding to the discharge port 151 formed in the cartridge 150.

[0051] In one embodiment of the present invention, the first needle seat 111a is shown to have four first protrusions 111c and four cutouts 111b, but the number of first protrusions 111c and cutouts 111b may be adjusted in various ways within the area of ​​the first needle seat 111a.

[0052] Meanwhile, when the first needle seat 111a is disposed in the inner space of the cartridge 150, the first protruding piece 111c may protrude toward the opening 151 formed in the cartridge 150. At this time, the first protruding piece 111c may protrude toward the opening 151 while being disposed in a vertical or inclined direction. For reference, in one embodiment of the present invention, the first protruding piece 111c is shown in the drawings as having a vertical orientation.

[0053] A plurality of the microneedles 111d may be formed at the tip of the first protruding piece 111c. The microneedles 111d are components that are directly inserted into the skin of the user. A plurality of the microneedles 111d are formed along the longitudinal direction of the first protruding piece 111c at predetermined intervals.

[0054] When the plurality of microneedles 111d formed on the first protruding piece 111c are inserted into the user's skin, the first protruding piece 111c and the microneedles 111d formed on the first protruding piece 111c can be supported by contacting one side that defines the opening 151 of the cartridge 150.

[0055] In other words, when the plurality of microneedles 111d formed on the first protruding piece 111c are about to break or bend during the process of inserting the first protruding piece 111c into the skin, they can be supported by coming into contact with one side that defines the opening 151 of the cartridge 150.

[0056] Therefore, the multiple microneedles 111d of the first needle sheet 111a to be inserted into the skin can be easily inserted into the skin without being bent or deformed by external forces because the first protruding piece 111c can be supported by one side of the opening 151.

[0057] The second needle sheet 113a is also a component incorporated into the inner space of the cartridge 150, and as shown in FIG. 4, is configured to include second projecting pieces 113c and microneedles 113d.

[0058] The second needle seat 113a can be said to be a component that contacts the top or bottom of the first needle seat 111a and overlaps it. In one embodiment of the present invention, it is described that the second needle seat 113a is stacked on the top surface of the first needle seat 111a, and the drawings also show that the second needle seat 113a is arranged on the top surface of the first needle seat 111a.

[0059] The second protruding piece 113c can be said to be a component formed by cutting out a part of the area of ​​the second needle seat 113a, that is, by cutting out a part of the area of ​​the second needle seat 113a and then bending it in one direction.

[0060] Therefore, a cutout 113b is formed in the second needle seat 113a to form the second protruding piece 113c. The cutout 113b formed in the second needle seat 113a may have a position and size corresponding to the cutout 111b formed in the first needle seat 111a.

[0061] In one embodiment of the present invention, the drawings show that the second needle seat 113a is provided with four second protrusions 113c and four incisions 113b, but this is not limited thereto, and the second needle seat 113a may be provided with a number of second protrusions 111c and incisions 111c corresponding to the number of first protrusions 111c and incisions 111c provided on the first needle seat 111a.

[0062] As shown in Figures 4 and 5, when the second needle sheet 113a is stacked on the upper surface of the first needle sheet 111a, the second protrusion piece 113c can be positioned at a predetermined distance from the first protrusion piece 111c while passing through the incision 111b formed in the first needle sheet 111a.

[0063] Conversely, although not shown in the drawing, when the first needle sheet 111a is stacked on the upper surface of the second needle sheet 113a, the first protruding piece 111c of the first needle sheet 111a may be positioned at a predetermined distance from the second protruding piece 113c while passing through the incision 113b formed in the second needle sheet 113a.

[0064] Meanwhile, the second protruding piece 113c can also protrude toward the opening 151 formed in the cartridge 150. In this case, the second protruding piece 113c can also protrude toward the opening 151 while being disposed in a vertical or inclined direction. For reference, in one embodiment of the present invention, the second protruding piece 113c is also shown in the drawings to have a vertical orientation.

[0065] The microneedles 113d of the second needle sheet 113a may be formed in plurality at the tip of the second protruding piece 113c. The microneedles 111d are components that are directly inserted into the user's skin. The microneedles 111d are formed in plurality along the longitudinal direction of the second protruding piece 113c at predetermined intervals.

[0066] When the plurality of microneedles 113d formed on the second protruding piece 113c are inserted into the user's skin, the second protruding piece 113c and the microneedles 113d formed on the second protruding piece 113c can be supported by contacting the other side that defines the opening 115 formed in the cartridge 150.

[0067] In other words, when the plurality of microneedles 113d formed on the second protruding piece 113c are about to break or bend during the process of inserting the second protruding piece 113c into the skin, they can be supported by coming into contact with the other side that defines the opening of the cartridge 150.

[0068] Therefore, the multiple microneedles 113d of the second needle sheet 113a inserted into the skin can be inserted into the skin without being broken or deformed by external forces, since the second protruding pieces 113c can be supported by the other side of the opening 151.

[0069] The second needle sheet 113a configured as described above serves to increase the density of the microneedles 111d, 113d within a limited planar space.

[0070] In other words, by increasing the density and number of microneedles 111d, 113d within the limited planar space formed by the cartridge 150, the needle insertion area that comes into contact with the user's skin is expanded, thereby further enhancing the subcutaneous delivery effect of the active ingredient or drug.

[0071] In one embodiment of the present invention, the first needle seat 111a and the second needle seat 113a are described and illustrated as being stacked on top of each other and installed in the inner space of the cartridge 150, but this is not limiting. For example, one needle seat may be used alone, or two or more needle seats may be stacked on top of each other to increase the density of the needles.

[0072] In addition, the first needle sheet 111a and the second needle sheet 113a can be made of a metal containing at least one of magnesium, calcium, zinc, and iron, which are used as bioabsorbable metals. Similarly, the protruding pieces 111c, 113c and the microneedles 111d, 113d provided on the first needle sheet 111a and the second needle sheet 113a can also be made of a metal containing at least one of magnesium, calcium, zinc, and iron, which are used as bioabsorbable metals.

[0073] Incidentally, there are cases in which magnesium-based alloys have been produced and commercialized domestically and internationally for use as bioabsorbable metals in orthopedic implants. Bioabsorbable metals applied to orthopedic implants focus on maximizing the rate of decomposition in the body for safe fracture fixation or improving corrosion resistance.

[0074] However, the bioabsorbable metal forming the first needle sheet 111a, second needle sheet 113a, protrusions 111c, 113c, and microneedles 111d, 113d in one embodiment of the present invention is different from bioabsorbable metals used in orthopedics, and can be applied with a mechanism that accelerates the decomposition rate in the body, allowing for the release of drugs and the supply of minerals in the skin.

[0075] For example, magnesium, calcium, and zinc, which are used as bioabsorbable metals, can have a mechanism for reacting with water in the body and decomposing while releasing hydrogen gas. Therefore, when the microneedles 111d and 113d provided on the first needle sheet 111a and the second needle sheet 113a, respectively, are inserted into the skin, they release ions and decomposition products under the skin, and one of the by-products, hydrogen gas, provides a swelling effect under the skin, which can also induce wrinkle improvement.

[0076] In addition, ZnO and MgCl, which are by-products produced when magnesium and zinc, components of bioabsorbable metals, are inserted into the body, can also function as drug delivery enhancers that remain subcutaneously and improve the subcutaneous absorption of active ingredients or drugs. Therefore, the first needle sheet 111a and the second needle sheet 113a formed from bioabsorbable metals also have the function of effectively delivering active ingredients or drugs carried therein or delivered from the outside into the subcutaneous tissue.

[0077] As shown in Figures 3 and 11, the elastic restoring portion 130 may be disposed in an inner space formed by the cartridge 150 together with the needle portion 110, and may be configured to be compressed by receiving a pressure transmitted from the body 170.

[0078] In more detail, the elastic restoring unit 130 is configured to be compressed or return to its original state by a force transmitted from the user. For example, when a force is transmitted from the user, the force can be transmitted to the needle unit 110. Then, the microneedles 111d and 113d provided in the needle unit 110 can be exposed to the outside through the opening 151 of the cartridge 150. Conversely, when the force from the user is released, the elastic restoring unit 130 provides a restoring force that allows the microneedles 111d and 113d inserted into the user's skin through the opening 151 of the cartridge 150 to return to their original state.

[0079] The elastic restoring portion 130 having the above-described function can be configured to include a first restoring means 131 and a second restoring means 133, as shown in FIGS.

[0080] The first restoring means 131 is a component disposed on the top of the needle portion 110, and in one embodiment of the present invention, can be pressed against the bottom of the body 170 while being stacked on top of the second needle seat 113a.

[0081] The second restoring means 133 is a component arranged at the bottom of the needle portion 110, and in one embodiment of the present invention, can elastically support the bottom of the first needle seat 111a while remaining placed on the bottom surface of the cartridge 150.

[0082] First, the first restoring means 131 may include a first restoring sheet 131a having an opening 131c formed therein whose position and size correspond to the incision 111b formed in the first needle sheet 111a, and a plurality of first elastic members 131b formed by incising a portion of the area of ​​the first restoring sheet 131a and bending upward at a predetermined angle to elastically contact the bottom of the body 170.

[0083] The second restoring means 133 is arranged on the bottom surface of the cartridge 150 and may include a second restoring sheet 133a having an opening 133c corresponding to the incision 111b formed in the first needle sheet 111a, and a plurality of second elastic members 133b formed by incising a portion of the area of ​​the second restoring sheet 133a and bent upward at a predetermined angle to elastically contact the bottom of the first needle sheet 111a.

[0084] The first restoring sheet 131a and the second restoring sheet 133a can have a plane area smaller than the plane area of ​​the first needle seat 111a or the second needle seat 113a. The first restoring sheet 131a and the second restoring sheet 133a can be made of a metal material or a plastic material having elastic restoring force.

[0085] When the body 170 moves vertically downward, the first elastic member 131b is pressed against the bottom of the body 170 and can be folded to have the same height as the first restoring sheet 131a. Conversely, when the force transmitted to the body 170 is released, the first elastic member 131b protrudes upward from above the first restoring sheet 131a and can return to its original state.

[0086] The first elastic member 131b may have a shape that protrudes obliquely upward from the first restoring sheet 131a and further protrudes horizontally. This shape can be said to be a shape that is easily pressed by the bottom of the body 170. In addition, when the force transmitted to the body 170 is released, the first elastic member 131b can be said to be a shape that is easily rotated on the first restoring sheet 131a and returned to its original state.

[0087] When the body 170 moves vertically downward, the second elastic member 133b is pressed against the bottom of the lowest needle seat 111a, 113a among the plurality of needle seats 111a, 113a constituting the needle portion 110, and can be folded to have the same height as the second restoring sheet 133a. For reference, in one embodiment of the present invention, the second elastic member 133b comes into contact with the bottom of the first needle seat 111a, and is therefore pressed against the first needle seat 111a when the body 170 moves vertically downward. Conversely, when the force transmitted to the body 170 is released, the second elastic member 133b protrudes upward from above the second restoring sheet 133a and can return to its original state.

[0088] The second elastic member 133b may also have a shape that protrudes obliquely upward from the second restoring seat 133a and further protrudes horizontally. This shape is easily pressed by the bottom of the first needle seat 111a or the second needle seat 113a, and easily rotates on the second restoring seat 133a and returns to its original state when the force transmitted to the body 170 is released.

[0089] Meanwhile, the second elastic members 133b have elastic force or rigidity smaller than that of the first elastic members 131b, or are provided on the second restoring sheet 133a in a number smaller than that of the first elastic members 131b.

[0090] As a result, when a first force from the user is transmitted to the body 170 and the body 170 descends, the second elastic member 133b provided on the second restoring sheet 133a can be compressed preferentially over the first elastic member 131b provided on the first restoring sheet 131a.

[0091] Then, the microneedles 111d and 113d of the needle part 110 are exposed through the opening 151 of the cartridge 150 by the first force applied by the user, and can be inserted into the user's skin.

[0092] Thereafter, when a second force greater than the first force is generated, the body 170 further descends, compressing the first elastic member 131b of the first restoring sheet 131a. As a result, the discharge member 175 of the body 170, which will be described later, is positioned close to the user's skin, allowing the active ingredient or drug to be rapidly and in large doses discharged to the user's skin.

[0093] As described above, by setting the elastic force, rigidity, and number of the first elastic member 131b and the second elastic member 133b to be different from each other, the first restoring means 131 and the second restoring means 133 can be compressed or restored with a time lag. Therefore, the user can appropriately adjust the pressure to sequentially realize the function of the drug delivery device through dual actions. For example, the first action of applying a first force can preferentially insert the microneedles 111d and 113d into the skin, and the second action of applying a second force can deliver a high dose of an active ingredient or drug to the skin.

[0094] As shown in FIGS. 11 to 13, the cartridge 150 forms a predetermined space in which the above-mentioned needle portion 110 and elastic restoring portion 130 can be housed.

[0095] Furthermore, a plurality of openings 151 are formed in the bottom of the cartridge 150 .

[0096] The openings 151 may be formed in various shapes and sizes at the bottom of the cartridge 150. In one embodiment of the present invention, the drawings show four openings 151 formed at predetermined intervals from one another.

[0097] In addition, the shape, size, and number of the openings 151 formed in the cartridge 150 can serve as the basis for the shape, size, and number of the incision openings 111b, 113b that constitute the needle portion 110 and the openings 131c, 133c that constitute the elastic recovery portion 130.

[0098] Furthermore, a portion of the first protruding piece 111c in the longitudinal direction, a portion of the second protruding piece 113c in the longitudinal direction, and the microneedles 111d and 113d can be exposed to the outside through the opening 151.

[0099] The body 170 is removably connectable to the cartridge 150 as shown in FIG.

[0100] It goes without saying that various known methods can be used to detachably couple the body 170 to the cartridge 150. For example, the cartridge 150 may be formed with a ring portion, and the body 170 may be formed with a protrusion that is inserted into the ring portion and locked thereto, thereby allowing the body 170 and the cartridge 150 to be detachably coupled to each other.

[0101] The reason why the body 170 and the cartridge 150 are detachably connected is to allow the user to easily replace the needle portion 110 and the elastic restoring portion 130 provided in the inner space of the cartridge 150.

[0102] As shown in Figures 9 and 10, the body 170 may include a storage space 171 in which an active ingredient or drug is stored, a guide channel 173 that is communicatively connected to the storage space 171 and through which the active ingredient or drug stored in the storage space 171 flows, and a discharge member 175 that guides the active ingredient or drug flowing along the guide channel 173 to the opening 151 of the cartridge 150.

[0103] The storage space 171 can be said to be a space in which the active ingredient or drug discharged from the storage unit 200 (see FIGS. 2 and 3) is stored for a predetermined period of time.

[0104] For reference, the body 170 and the storage unit 200 can be interconnected via a connecting part 190, as shown in Figures 2 and 3. That is, the connecting part 190 has a hollow shape, and one side thereof can be detachably connected to the open top of the body 170. The other side of the connecting part 190 can be detachably connected to the storage unit 200.

[0105] The connecting portion 190 may be detachably coupled to the body 170 or the storage portion 200 by any of a variety of known fastening methods, such as an interference fit method or a screw fastening method.

[0106] In addition, the reservoir 200 may have a predetermined strength while providing a space for storing an active ingredient or drug. The reservoir 200 may be manufactured in various types such as a container type or a capsule type.

[0107] Therefore, the active ingredient or drug discharged from the reservoir 200 can be temporarily retained in the storage space 171 of the body 170 via the connecting part 190 .

[0108] The active ingredient or drug remaining in the storage space 171 can flow into the guide channel 173.

[0109] The guide channels 173 may be provided in the body 170 at positions and in numbers corresponding to the positions and numbers of the openings 151 formed in the cartridge 150 .

[0110] The guide channel 173 may be formed in the body 170 in a gradually narrowing shape to increase the flow rate of the active ingredient or drug stored in the storage space 171. For example, the guide channel 173 may be defined by a pair of inclined surfaces.

[0111] The discharge member 175 is connected to the guide passage 173 so as to be able to communicate with it, and has a shape that protrudes from the bottom surface of the body 170 as shown in FIG.

[0112] The discharge member 175 can be sequentially inserted into the opening 131c formed in the first restoring sheet 131a, the incisions 111b and 113b formed in the needle portion 110, and the opening 133c formed in the second restoring sheet 133a.

[0113] That is, when the body 170 descends, the discharge member 175 passes through the opening 131c of the first restoring sheet 131a, the incisions 111b and 113b of the needle portion 110, and the opening 113c of the second restoring sheet 133a in that order, and is positioned at a position corresponding to the opening 151 formed in the cartridge 150. In this state, the active ingredient or drug can be rapidly delivered to the skin via the guide channel 173.

[0114] Here, the discharge member 175 passes through the space formed between the first protruding piece 111c formed on the first needle sheet 111a and the second protruding piece 113c formed on the second needle sheet 113a, and therefore also plays a role in smoothing down the medicine applied to the first protruding piece 111c and the second protruding piece 113c and quickly delivering it to the user's skin.

[0115] Furthermore, since the discharge member 175 is configured to be positioned between the first protruding piece 111c and the second protruding piece 113c, it can support the first protruding piece 111c and the second protruding piece 113c when the multiple microneedles 111d formed on the first needle sheet 111a and the multiple microneedles 133d formed on the second needle sheet 113a are inserted into the skin.

[0116] The discharge member 175 cooperates with one side that defines the opening 151 of the cartridge 150 to prevent the first protruding piece 111c and the microneedle 111d of the first needle sheet 111a from bending or deforming in the other direction, and cooperates with the other side that defines the opening 151 of the cartridge 150 to prevent the second protruding piece 113c and the microneedle 113d of the second needle sheet 113a from bending or deforming in one direction.

[0117] That is, the ejection member 175 prevents the formation of a space that may cause the first protruding piece 111c and the second protruding piece 113c to bend or deform.

[0118] Therefore, the discharge member 175 can also serve to further prevent the microneedles 111d and 113d having micro units from being unintentionally broken or deformed during the process of being inserted into the skin.

[0119] In the stamp-type drug delivery device according to one embodiment of the present invention having the above-described configuration, when multiple microneedles formed on a thin metal plate are inserted into the skin, the first protruding piece or the second protruding piece supporting the microneedles is supported on the inner wall surface defining the opening of the cartridge, or is supported by the discharge member of the body that descends to discharge the active ingredient or drug, thereby preventing the microneedles from breaking or deforming.

[0120] Furthermore, a configuration is provided in which microneedles arranged at a high density within a limited area are preferentially inserted into the skin, so that active ingredients or drugs can be easily delivered subcutaneously through the microneedles and the skin can be stimulated to provide beneficial effects.

[0121] Although specific embodiments of the present invention have been described above, it is obvious that various modifications can be made without departing from the scope of the present invention.

[0122] For example, as shown in FIG. 14, in order to enhance the subcutaneous delivery effect of an active ingredient or drug, slits S that allow the active ingredient or drug to be carried and flow can be formed in the microneedles 111d, 113d.

[0123] The slits S may be formed in a direction parallel to the insertion direction of the microneedles 111d and 113d, allowing the active ingredient, a drug, to be delivered to the skin quickly and easily.

[0124] It goes without saying that the length or width and the position where the slit S is formed can be set in various ways according to the shape and size of the microneedles 111d and 113d.

[0125] Furthermore, the stamp-type drug delivery device 100 according to one embodiment of the present invention has been described as delivering the active ingredient or drug stored in the storage unit 200 to the skin after passing through the connecting unit 190, the body 170, the needle unit 110, and the cartridge 150 in sequence, but is not limited thereto.

[0126] For example, as shown in Fig. 15, the reservoir 200 for storing the active ingredient or drug may be omitted. Instead, the body 170 may be modified to have a shape and volume that allows it to store the active ingredient or drug, and the connecting part 190 may serve as a cap that covers the open top of the body 170.

[0127] Furthermore, as described above, the stamp-type drug delivery device 100 according to one embodiment of the present invention has a needle portion 110 made of a metal containing components beneficial to the human body, so that the microneedles 111d and 113d themselves alone can provide beneficial effects to the user.

[0128] Therefore, it goes without saying that a user can use the stamp-type drug delivery device 100 according to the present invention only to insert the microneedles 111d and 113d into the skin, and in such a case, the storage unit 200, which is a component for storing an active ingredient or drug, may be omitted. In this case, the body 170 serves to transmit the user's force to the needle unit 110 and to prevent the first protruding piece 111c, the second protruding piece 113c, and the microneedles 111d and 113d from being broken or deformed when the microneedles 111d and 113d are inserted into the skin.

[0129] Therefore, the scope of the present invention should not be limited to the described embodiments, but should be defined by the following claims as well as equivalents thereto.

Claims

1. a needle portion having a predetermined area and provided with a plurality of microneedles to be inserted into the skin of a user; an elastic recovery portion that elastically contacts the needle portion; a cartridge that provides a space for accommodating the needle portion and the elastic recovery portion and has a plurality of openings formed in a bottom portion; a body coupled to the cartridge and configured to apply pressure to the elastic restoring portion by a force transmitted from a user; A stamp-type drug delivery device capable of delivering high doses of drugs.

2. The needle portion is A first needle seat; a first protruding piece formed by cutting a part of the area of ​​the first needle seat and protruding toward the opening of the cartridge; a plurality of microneedles provided at the tip of the first projecting piece; The stamp-type drug delivery device capable of delivering a high dose of drug according to claim 1.

3. When the plurality of microneedles provided on the first protruding piece are inserted into the skin of a user, the first protruding piece and the microneedles formed on the first protruding piece may be supported on one side surface that defines the opening of the cartridge. The stamp-type drug delivery device capable of delivering a high dose of drug according to claim 2.

4. The elastic recovery portion is a first restoring means that is stacked on top of the first needle seat and pressed against the body; and a second restoring means disposed below the first needle seat and elastically supporting the bottom of the first needle seat. The stamp-type drug delivery device capable of delivering a high dose of drug according to claim 2.

5. The first restoration means a first restoring sheet having an opening formed therein corresponding to the incision formed in the first needle sheet; a plurality of first elastic members formed by cutting out a portion of the area of ​​the first restoring sheet and bent upward at a predetermined angle to elastically contact the bottom of the body; The stamp-type drug delivery device capable of delivering a high dose of drug according to claim 4.

6. The second restoration means a second restoring sheet disposed on a bottom surface of the cartridge and having an opening corresponding to the incision formed in the first needle sheet; a plurality of second elastic members formed by cutting out a portion of the area of ​​the second restoring sheet and bent upward at a predetermined angle to elastically contact the bottom of the first needle sheet; The stamp-type drug delivery device capable of delivering a high dose of drug according to claim 5.

7. The second elastic members have elastic force or rigidity smaller than that of the first elastic members, or are provided on the second restoring sheet in a number smaller than that of the first elastic members. The stamp-type drug delivery device capable of delivering a high dose of drug according to claim 6.

8. The body is a storage space in which an active ingredient or a drug is stored; a guide channel that is connected to the storage space so as to be able to communicate with the storage space, and through which the active ingredient or drug stored in the storage space flows; a discharge member that guides the active ingredient or drug flowing along the guide flow path to the opening of the cartridge. The stamp-type drug delivery device capable of delivering a high dose of drug according to claim 2.

9. The body further includes a connector, one side of which is connected to the upper end thereof and the other side of which is connected to a reservoir in which an active ingredient or drug is stored. The stamp-type drug delivery device capable of delivering a high dose of drug according to claim 1.

10. The needle portion is a second needle seat overlapping the first needle seat; a second protruding piece formed by cutting a part of the area of ​​the second needle seat and protruding toward the opening of the cartridge; a plurality of microneedles provided at the tip of the second projecting piece, The second protruding piece is disposed at a predetermined distance from the first protruding piece. The stamp-type drug delivery device capable of delivering a high dose of drug according to claim 2.

11. When the plurality of microneedles provided on the second protruding piece are inserted into the skin of a user, the second protruding piece and the microneedles formed on the second protruding piece may be supported by another side surface that defines the opening of the cartridge. The stamp-type drug delivery device capable of delivering a high dose of drug according to claim 10.

12. When the second needle sheet is stacked on the upper surface of the first needle sheet, the second protruding piece is disposed at a predetermined interval from the first protruding piece while passing through the cutout formed in the first sheet, When the first needle sheet is stacked on the upper surface of the second needle sheet, the first protruding piece passes through the cutout formed in the second needle sheet and is disposed at a predetermined distance from the second protruding piece. The stamp-type drug delivery device capable of delivering a high dose of drug according to claim 10.

13. The microneedles of the needle part have slits that allow active ingredients or drugs to be carried and flow. The stamp-type drug delivery device capable of delivering a high dose of drug according to claim 10.

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