Thermophysiologic micro-nano wafer medicine integrated transdermal drug delivery device

Abstract

The application relates to a hot compress type micro-nanometer wafer medicine integrated transdermal drug delivery device, which comprises a medicine tank for storing medicine liquid, a nanometer wafer, a heating assembly, a driving assembly, a power supply and a controller; the nanometer wafer, the heating assembly and the driving assembly are connected with the medicine tank; the heating assembly and the driving assembly are connected with the power supply and the controller; a plurality of micro-needles for piercing the skin are arranged on the side of the nanometer wafer away from the medicine tank; the micro-needles are provided with through holes communicated with the medicine tank; the heating assembly is used for heating the medicine liquid in the medicine tank; the driving assembly comprises a pulse electromagnetic coil and a permanent magnet; the permanent magnet is arranged on the medicine tank; the pulse electromagnetic coil is arranged opposite to the permanent magnet and is connected with the power supply and the controller; the power supply is used for supplying power to the heating assembly and the driving assembly; the controller is used for controlling the heating temperature of the heating assembly and controlling the driving assembly to drive the nanometer wafer to perform mechanical reciprocating motion before each drug delivery.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medical devices, in particular to a hot compress type micro-nano wafer drug and device integrated transdermal drug delivery device. BACKGROUND

[0002] Nanometer microneedle wafers are widely used in the field of transdermal device technology. Nanometer microneedles are formed by processing a large number of micro-nano pyramid structures on a single crystal silicon substrate using semiconductor technology. The size of the needle tip is usually in the nanometer scale, so it is also called nanometer microneedle. The arrangement of these microneedles is mainly rectangular array, and the spacing of the microneedles is usually between 300-1000 microns, and the height of the microneedles is in the range of 70-300 microns. Take a small piece of semiconductor block covered with microneedles, such as 4mm x 4mm, and press the small block on the skin. The stratum corneum on the surface of the skin will be pierced, and then the skin is coated with ointment, so that the absorption of the drug on the skin surface can be enhanced. This technology is widely used in the skin beauty industry.

[0003] Nanometer microneedle wafers are mainly used in nanometer wafer penetration enhancer instruments such as microneedle beauty instruments. These products usually include a needle and a driving device for driving the needle to perform a piercing motion. The nanometer microneedle wafer is manually loaded on the driving device through an external thread. The driving device mostly uses a motor and a steering mechanism in combination. The motor converts the rotating motion into a reciprocating motion through a cam, thereby driving the microneedle to perform a needling action. This structure design is usually complex, and the production cost is high, and the noise is also large, which is not conducive to the user's experience comfort. In addition, the existing technology applies the drug after needling, and the drug cannot be used in time. SUMMARY

[0004] To solve the above technical problems, the purpose of the present application is to provide a hot compress type micro-nano wafer drug and device integrated transdermal drug delivery device. The present application drives the nanometer wafer to perform mechanical reciprocating motion before each drug delivery by the magnetic field generated by the pulse electromagnetic coil, thereby realizing the piercing action of the nanometer wafer, and can heat the drug liquid, promote drug absorption, and enhance the comfort of contacting the skin.

[0005] To achieve the above purpose, the present application adopts the following technical solutions:

[0006] The application discloses a hot compress type micro-nanometer wafer medicine device integrated transdermal drug delivery device.

[0007] Further, the side of the medicine tank away from the nanometer wafer is provided with a connecting rod, the permanent magnet is located at the end of the connecting rod away from the medicine tank, a shell is sleeved on the outside of the end of the connecting rod away from the medicine tank, the outside of the connecting rod is sleeved with a first spring and a second spring, the first spring is located outside the shell, the second spring is located inside the shell, and the pulse electromagnetic coil is located inside the shell.

[0008] Further, the outside of the shell is provided with a positioning pin, and the positioning pin is located between the first spring and the second spring.

[0009] Further, the pulse electromagnetic coil comprises a solenoid and a solenoid coil sleeved outside the solenoid, and the inside of the solenoid is provided with an iron core.

[0010] Further, the microneedle is in a pyramid shape, the height of the microneedle is 70-300 microns, and the interval between two adjacent microneedles is 300-1000 microns.

[0011] Further, the aperture of the through hole is 5-20 microns.

[0012] Further, the heating assembly is located on the side wall and the bottom wall of the medicine tank.

[0013] Further, the heating assembly is a PTC heat-sensitive ceramic sheet.

[0014] Further, the heating assembly and the driving assembly are connected with the power supply and the controller through lead wires.

[0015] Further, the controller is a PLC controller, and preferably a single-chip microcomputer.

[0016] Further, the permanent magnet is a permanent magnet.

[0017] By means of the above scheme, the application has at least the following advantages:

[0018] Further, the permanent magnet is a permanent magnet.The heat compress type micro-nano wafer medicine and instrument integrated transdermal drug delivery device drives the permanent magnet arranged on the medicine tank by the magnetic field of the pulse electromagnetic coil to realize the puncture of the microneedle; secondly, the heating assembly connected with the medicine tank provides certain temperature for the medicine liquid and the microneedle, and the comfort of the skin is enhanced; thirdly, the microneedle is provided with a through hole, and the medicine liquid is directly delivered to the skin through the capillary effect without additional medicine application. The heat compress type micro-nano wafer medicine and instrument integrated transdermal drug delivery device has simple structure, reduced production cost, reduced noise, extremely reasonable drug amount, and greatly improved reliability and comfort.

[0019] The above description is only a summary of the technical scheme of the present application, in order to more clearly understand the technical means of the present application, and the content of the specification can be implemented. The following will be described in detail with the preferred embodiment of the present application and with the accompanying drawings. BRIEF DESCRIPTION OF DRAWINGS

[0020] Figure 1 It is a structure schematic view of the heat compress type micro-nano wafer medicine and instrument integrated transdermal drug delivery device of the present application.

[0021] Explanation of reference signs:

[0022] 1-microneedle; 2-medicine tank; 3-medicine liquid; 4-PTC heat-sensitive ceramic sheet; 5-lead; 6-connecting rod; 7-first light spring; 8-positioning pin; 9-second light spring; 10-permanent magnet; 11-iron core; 12-solenoid; 13-solenoid coil; 14-through hole; 15-power supply and single-chip microcomputer; 16-housing. DETAILED DESCRIPTION

[0023] The specific embodiments of the present application will be further described in detail below in combination with the drawings and examples. The following examples are used to illustrate the present application, but not to limit the scope of the present application.

[0024] Example

[0025] Referring to the drawings, a heat compress type micro-nano wafer medicine and instrument integrated transdermal drug delivery device of a preferred embodiment of the present application comprises a medicine tank 2 for storing a medicine liquid 3, a nano wafer, a heating assembly, a driving assembly, a power supply and a controller; the nano wafer, the heating assembly and the driving assembly are all connected with the medicine tank 2, and the heating assembly and the driving assembly are both connected with the power supply and the controller through the lead 5. The heating assembly is used for heating the medicine liquid 3 in the medicine tank 2, the power supply is used for supplying power to the heating assembly and the driving assembly, and the controller is used for controlling the heating temperature of the heating assembly and controlling the driving assembly to drive the nano wafer to mechanically reciprocate before each drug delivery. The controller is preferably a single-chip microcomputer.

[0026] Specifically, the nanocrystal sheet is completed by a semiconductor manufacturing process and adhered to the top end of the medicine tank 2. The side of the nanocrystal sheet away from the medicine tank 2 is provided with a plurality of micro-needles 1 arranged at intervals for piercing the skin, and each micro-needle 1 is provided with a through hole 14, one end of which is in contact with the liquid medicine 3 in the medicine tank 2 and the other end is in communication with the outside. The micro-needle 1 is in the shape of a pyramid, the height of the micro-needle 1 is 70-300 microns, and the distance between two adjacent micro-needles 1 is 300-1000 microns. The aperture of the through hole 14 is 5-20 microns. During use, the capillary action of the through hole 14 and the stable temperature of the medicine tank 2 enable the liquid medicine 3 to continuously supply the skin with the liquid medicine 3.

[0027] The heating assembly is a PTC thermosensitive ceramic sheet 4, which is attached to the outer surface of the outer side wall and bottom wall of the medicine tank 2. On the one hand, it heats the medicine tank 2 and the liquid medicine 3, and then transmits heat to the nanocrystal sheet installed on the top of the medicine tank 2. After the PTC thermosensitive ceramic sheet 4 is powered on, it self-heats and warms up, the resistance value enters the jump region, and the surface temperature remains stable, which also provides a stable heat source for the medicine tank 2. At the same time, the PTC thermosensitive ceramic sheet 4 is cost-effective, long-lasting, safe, green and environmentally friendly, saves electricity, and adjusts its heat power output according to changes in environmental temperature. It can optimize the control of heater power consumption to a minimum, and the high-heating-efficiency material also greatly improves the efficiency of electricity utilization.

[0028] The driving assembly includes a pulse electromagnetic coil and a permanent magnet 10, the permanent magnet 10 is arranged on the bottom of the medicine tank 2, and the pulse electromagnetic coil is arranged opposite to the permanent magnet 10 and connected with the power supply and the controller. The pulse frequency of the pulse electromagnetic coil can be freely set according to requirements, such as the user's feeling of the micro-needles 1 touching the surface skin to determine the appropriate electromagnetic pulse frequency. The side of the medicine tank 2 away from the nanocrystal sheet is provided with a connecting rod 6, the permanent magnet 10 is located at the end of the connecting rod 6 away from the medicine tank 2, a shell 16 is arranged outside the end of the connecting rod 6 away from the medicine tank 2, the connecting rod 6 is externally sleeved with a first light spring 7 and a second light spring 9, the first light spring 7 is located outside the shell 16, the second light spring 9 is located inside the shell 16, and the pulse electromagnetic coil is located inside the shell 16. The shell 16 is externally provided with a positioning pin 8, and the positioning pin 8 is located between the first light spring 7 and the second light spring 9. The pulse electromagnetic coil includes a solenoid 12 and a solenoid coil 13 sleeved outside the solenoid 12, and the solenoid 12 is internally provided with an iron core 11 to enhance the magnetic performance of the solenoid coil 13. The solenoid 12 is connected with the power supply and the single-chip microcomputer 15 through the lead wire 5.

[0029] When the hot compress type micro-nano wafer medicine integrated transdermal drug delivery device is powered on, the solenoid 13 in the pulse electromagnetic coil is magnetized, at this time the magnetic pole at the upper end of the electromagnetic coil and the lower end magnetic pole of the permanent magnet 10 installed at the bottom of the medicine tank 2 continuously attract or repel each other with the change of time, so as to drive the needle puncture action of the nano wafer, so that the microneedle 1 can painlessly and efficiently input the medicine into the subcutaneous tissue. When the microneedle 1 pierces the stratum corneum, the heat generated by the PTC heat-sensitive ceramic sheet 4 is transmitted to the skin surface through the microneedle 1 via the medicine tank 2, and the medicine 3 is transmitted into the horny skin through the capillary action of the microneedle 1 hole under the action of heat, thereby enhancing the blood circulation in the epidermis, promoting drug absorption, and playing a hot compress role, and also greatly enhancing the comfort of contacting the skin. This structure not only has rapid drug effect, but also has better body feeling.

[0030] The above is only the preferred embodiment of the present application, and is not used to limit the present application. It should be pointed out that for ordinary skilled persons in the art, several improvements and modifications can be made without departing from the technical principles of the present application, and these improvements and modifications should be considered as the protection scope of the present application.

Claims

1. A transdermal drug delivery device integrating a heat-contact micro / nano wafer, characterized in that: The application relates to a drug delivery device, which comprises a medicine tank for storing medicine, a nanocrystal sheet, a heating assembly, a driving assembly, a power supply and a controller; the nanocrystal sheet, the heating assembly and the driving assembly are connected with the medicine tank; the heating assembly and the driving assembly are connected with the power supply and the controller; a plurality of microneedles for piercing the skin are arranged on the side of the nanocrystal sheet away from the medicine tank; the microneedles are provided with through holes in communication with the medicine tank; the heating assembly is used for heating the medicine in the medicine tank; the driving assembly comprises a pulse electromagnetic coil and a permanent magnet; the permanent magnet is arranged on the medicine tank; the pulse electromagnetic coil is arranged opposite to the permanent magnet and is connected with the power supply and the controller; the power supply is used for supplying power to the heating assembly and the driving assembly; the controller is used for controlling the heating temperature of the heating assembly and controlling the driving assembly to drive the nanocrystal sheet to perform mechanical reciprocating motion before each time of medicine delivery. The microneedles are in pyramid shape, the height of the microneedles is 70-300 microns, the distance between two adjacent microneedles is 300-1000 microns, and the aperture of the through hole is 5-20 microns. A connecting rod is arranged on the side of the medicine tank away from the nanocrystal sheet; the permanent magnet is arranged at the end of the connecting rod away from the medicine tank; a shell is arranged on the outer part of the end of the connecting rod away from the medicine tank; the outer part of the connecting rod is sleeved with a first spring and a second spring; the first spring is arranged outside the shell; the second spring is arranged inside the shell; and the pulse electromagnetic coil is arranged inside the shell.

2. The hot compress type micro-nano wafer medicine integrated transdermal drug delivery device according to claim 1, characterized in that: A positioning pin is arranged outside the shell and between the first spring and the second spring.

3. The hot compress type micro-nanochip medicine integrated transdermal drug delivery device according to claim 1 or 2, characterized in that: The pulse electromagnetic coil comprises a solenoid and a solenoid coil sleeved outside the solenoid; and the solenoid is provided with an iron core inside.

4. The hot compress type micro-nano wafer medicine integrated transdermal drug delivery device according to claim 1, characterized in that: The heating assembly is arranged on the side wall and the bottom wall of the medicine tank.

5. The hot compress type micro-nano chip medicine integrated transdermal drug delivery device according to claim 1 or 4, characterized in that: The heating assembly is a PTC thermosensitive ceramic sheet.

6. The hot compress type micro-nano wafer medicine integrated transdermal drug delivery device according to claim 1, characterized in that: The heating assembly and the driving assembly are connected with the power supply and the controller through lead wires.

7. The hot compress type micro-nano wafer medicine integrated transdermal drug delivery device according to claim 1, characterized in that: The controller is a PLC controller.

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