Use of 2-methyloxolane for feeding oviparous animals

2-Methyloxolane supplementation in animal feed addresses hexane's drawbacks by enhancing egg production in oviparous animals like chickens and pheasants, achieving safe and effective results with minimal environmental impact.

JP2025532439APending Publication Date: 2025-09-30エコストラクト
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Patent Information

Application Number
JP2025519900
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-10-06
Filing Date
2023-10-05
Publication Date
2025-09-30

AI Technical Summary

Technical Problem

Hexane, commonly used in oil extraction from oleaginous plant cakes, poses health and environmental risks, necessitating the development of a safer alternative solvent for animal feed that enhances egg production in oviparous animals.

Method used

2-Methyloxolane is used as a dietary supplement in animal feed, particularly for chickens and pheasants, to increase egg production, offering non-toxic and bio-sourced properties.

Benefits of technology

2-Methyloxolane supplementation results in up to 14% higher egg production per week in egg-laying animals, with low residue levels compatible with human exposure limits and potential weight gain.

✦ Generated by Eureka AI based on patent content.

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Abstract

The present invention relates to the use of 2-methyloxolane for feeding oviparous animals.
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Description

[Technical Field]

[0001] The present disclosure relates to the field of feeding egg-laying animals, particularly pheasants, and more particularly chickens. [Background technology]

[0002] Oleaginous plant cake is commonly used in animal feeding as a source of metabolizable energy as well as a protein supplement. Oleaginous plant cake is the solid residue resulting from the edible oil production process by solid / liquid extraction of oleaginous plant grains.

[0003] Currently, hexane is the most commonly used solvent in solid / liquid extraction because it has advantageous properties. In fact, hexane allows for highly efficient oil extraction (>97%), leaving less than 3% residual oil in the solid substrate, thereby preventing the solid substrate from spoiling. Hexane is easy to separate from the extracted oil, has a suitable boiling point (i.e., high enough to limit losses during extraction, but low enough to limit energy consumption during its separation from the extracted oil and its recycling), is stable, and has good lipid selectivity.

[0004] Oil cakes contain hexane and their hexane content is regulated in some regions, for example in Europe the maximum hexane content allowed in cake is 1,000 mg / kg.

[0005] Nevertheless, hexane has major drawbacks: it is derived from petroleum, is neurotoxic, and is classified as a Category 2 reproductive toxicant and Category 2 aquatic toxicant. Hexane is classified by pharmaceutical industry experts (ICHQ3C R8) as a "solvent to be restricted," and the tolerable daily dose for an average person weighing 50 kg is only 2.9 mg.

[0006] Therefore, alternative solvents to hexane are being tested in the laboratory and on a pilot scale. For example, the applicant's European Patent Application No. 19 842 832.3 describes the production of defatted cake by solid / liquid extraction of soybean, rapeseed, corn, cotton, and sunflower with a binary mixture of 2-methyloxolane and water.

[0007] In seeking to quantify the presence of 2-methyloxolane residues in chicken eggs, Applicant observed, quite unexpectedly, that chickens whose feed was supplemented with 2-methyloxolane laid more eggs than chickens whose feed was not supplemented with 2-methyloxolane. Summary of the Invention

[0008] Thus, there is provided the use of a dietary supplement comprising 2-methyloxolane to increase egg production in oviparous animals, particularly pheasants, and more particularly chickens.

[0009] Advantageously, egg-laying animals whose diets are supplemented with a nutritional supplement comprising 2-methyloxolane produce up to 14% more eggs per week than egg-laying animals whose diets are not supplemented with a nutritional supplement comprising 2-methyloxolane of the present invention.

[0010] 2-Methyloxolane is also non-toxic when ingested in the amounts contemplated in animal feed. Indeed, a published study of 3-month ingestion in rats showed no undesirable effects observed at doses of 250 mg / kg body weight per day. Therefore, dietary supplements containing 2-methyloxolane are not toxic to animals whose diets are supplemented with said dietary supplements.

[0011] Furthermore, the concentrations of 2-methyloxolane residues present in meat from oviparous animals whose feed is supplemented with a food supplement containing 2-methyloxolane, and in eggs laid by oviparous animals whose feed is supplemented with a food supplement containing 2-methyloxolane, are very low and compatible with the human exposure limit recommended by EFSA of 1 mg / kg human body weight / day (EFSA Opinion on 2-methyloxolane of 15 March 2020).

[0012] Furthermore, some oviparous animals whose diets are supplemented with dietary supplements containing 2-methyloxolane can gain significant weight.

[0013] Furthermore, 2-methyloxolane is bio-sourced, as its raw materials are usually derived from sugarcane bagasse or corn cobs. Furthermore, it is not classified as toxic to the environment.

[0014] In another aspect, there is provided a dietary supplement for feeding egg-laying animals, particularly pheasants, more particularly chickens, said dietary supplement comprising 2-methyloxolane.

[0015] In another aspect, there is provided the use of a kit for increasing egg production in oviparous animals, particularly pheasants, more particularly chickens, said kit comprising: a dietary supplement comprising 2-methyloxolane as described herein above; Composition for feeding egg-laying animals, in particular pheasants, more particularly chickens - Patent 7222447 Includes.

[0016] In another aspect, there is provided a kit for feeding egg-laying animals, particularly pheasants, more particularly chickens, said kit comprising: a dietary supplement comprising 2-methyloxolane as described herein above; Composition for feeding egg-laying animals, in particular pheasants, more particularly chickens - Patent 7222447 Includes.

[0017] In another aspect, there is provided the use of a food product for increasing egg production in oviparous animals, particularly pheasants, more particularly chickens, said food product comprising: a dietary supplement comprising 2-methyloxolane as described herein above; Composition for feeding egg-laying animals, in particular pheasants, more particularly chickens - Patent 7222447 Includes:

[0018] In another aspect, there is provided a food product intended to be fed to egg-laying animals, in particular pheasants, more particularly chickens, said food product comprising: a dietary supplement comprising 2-methyloxolane as described herein above; Composition for feeding egg-laying animals, in particular pheasants, more particularly chickens - Patent 7222447 Includes:

[0019] In another aspect, there is provided a dietary supplement as described herein above, a kit as described herein above, or a food product as described herein above for use thereof in increasing egg production in oviparous animals, particularly pheasants, more particularly chickens.

[0020] In another aspect, there is provided a method for increasing egg production in an oviparous animal, in particular a pheasant, more particularly a chicken, comprising the step of ingestion by the oviparous animal, in particular a pheasant, more particularly a chicken, of a dietary supplement as described herein above, of a kit as described herein above, or of a food product as described herein above. DETAILED DESCRIPTION OF THE INVENTION

[0021] In a first aspect, there is provided the use of a dietary supplement comprising 2-methyloxolane to increase egg production in oviparous animals, particularly pheasants, more particularly chickens.

[0022] In the context of the present application, "oviparous animals" refers to animals that lay eggs and in which embryonic development occurs. Birds of the pheasant family are an example of oviparous animals.

[0023] In the context of this application, "pheasant" refers to a family of omnivorous birds generally characterized by stocky bodies, thick spouts, short, rounded feathers, and sturdy legs. The Phasianidae family includes several subfamilies. Chickens, roosters, quails, peacocks, partridges, and guineafowl are among these subfamilies.

[0024] In the context of the present application, "dietary supplement" refers to a foodstuff intended to achieve a normal diet and which forms a concentrated source of nutrients or other substances having a nutritional or physiological effect.

[0025] Typically, in this use, the amount of 2-methyloxolane administered to oviparous animals, in particular pheasants, more particularly chickens, may be comprised between 0.1 and 200 mg / kg oviparous animal / day, in particular 1 mg / kg oviparous animal / day, more particularly 3 to 32 mg / kg oviparous animal / day.

[0026] Advantageously, egg production of oviparous animals is increased when the amount of 2-methyloxolane taken up by said oviparous animals is administered within these ranges.

[0027] The dietary supplement used may be in the form of a solution, powder, capsule, extrudate, tablet or biological matrix cake, in particular in the form of a powder, capsule or biological matrix cake, more particularly in the form of a biological matrix cake.

[0028] In the dietary supplement used, the 2-methyloxolane may be in liquid form or may be impregnated over a food-grade carrier for oviparous animals in the dietary supplement used.

[0029] For example, 2-methyloxolane in liquid form is suitable for dietary supplements in the form of solutions and capsules, and impregnation of 2-methyloxolane is suitable for dietary supplements in the form of powders, extrudates, tablets, or cakes of biological substrates.

[0030] These formats are easy to produce because they are well known to those skilled in the art, and 2-methyloxolane is a liquid under atmospheric pressure and temperature conditions, so it can be easily impregnated onto a food-grade carrier by known techniques.

[0031] For example, the food-grade carrier of the dietary supplement can be selected from a mineral carrier or a biological carrier. For example, the mineral carrier can be a mineral powder, such as silica powder. Tixosil® 68 powder is an example of a silica powder adapted to be used as a mineral carrier.

[0032] In the context of the present application, "biological substrate cake" is understood to be the solid residue of the extraction of oil or juice from a biological substrate.

[0033] In the context of the present application, "biological substrate" is understood to be a solid material selected from plants, algae, microorganisms and mixtures thereof, in particular plants.

[0034] For example, the plant may be an oleaginous plant, a proteaginous plant, or a mixture thereof.

[0035] As oleaginous plants, mention may be made of rapeseed, sunflower, soybean, peanut, sesame, walnut, almond, cotton, linseed or mixtures thereof, in particular rapeseed, sunflower, soybean or mixtures thereof.

[0036] Examples of proteaginous plants include peas, beans, lupines, and mixtures thereof.

[0037] Typically, biological substrates include almonds, amaranth, peanuts, argan, sea buckthorn, cashew trees, avocados, oats, borage, safflower, camelina, carrots, cocao, cashews, canola, hemp, rapeseed, copra, mallow, cotton, croton, rose hips, fig, prickly pear, pomegranate, hops, illipe, jojoba, jasmine, shea trees, lavender, lavandin, linseed, lupin, corn, hazel trees, walnuts, coconut palms, poppies, olives, evening primroses, orange trees, oil palms, paprika, pecans, pistachios, peppers, castor beans, rice, roses, cedar roses, musk roses, sesame, soybeans, marigolds, sunflowers, and Calophyllum inophyllum), moix, macadamia nut, raspberry, blackcurrant, melon, grape, tomato, baobab, babassu, cranberry, chia, pumpkin, mustard, neem, nigella, niger, poppy, perilla, Plukenetia volubili, winter squash, annatto, taramira, apricot, plum, peach, wheat, moonflower, ylang-ylang, geranium, patchouli, petitgrain (citrus), anise, caraway, juniper, bergamot, mandarin orange, grapefruit, lemon, nutmeg tree, celery, angelica, cardamom, cumar, vanilla, vetiver, iris, sandalwood, laurel wreath, tarragon, citronellol The plant may be selected from among nera, sage, mint, pine tree, rosemary, fir tree, thyme, galbanum, elemi, benzoin, myrrh, olibanum tree, and mixtures thereof, in particular soybean, rapeseed, sunflower, baobab, corn, peanut, coconut, oil palm, cotton, and mixtures thereof, more particularly soybean, rapeseed, sunflower, baobab, and mixtures thereof.

[0038] In particular embodiments, the biological substrate cake is a cake of soybean, rapeseed, sunflower, corn, peanut, and mixtures thereof.

[0039] The biological substrate cake may be in the form of a cake or an extrudate powder.

[0040] In the context of the present application, "cake flour" is understood to be the by-product obtained from crushing, milling or spraying cake to obtain said flour.

[0041] Advantageously, cake flour is easy to eat and very well digested by oviparous animals.

[0042] In the context of the present application, an "extrudate" is understood to be a product whose production is carried out by extrusion.

[0043] The cake of the biological substrate may be obtained from a process for producing oil by solid / liquid extraction using 2-methyloxolane. Such a process is described, for example, in European Patent Application No. 19 842 832.3.

[0044] Typically, the mass concentration of 2-methyloxolane in the cake of the biological substrate may be less than 1,000 mg / kg, in particular between 10 mg / kg and 500 mg / kg, more particularly between 100 mg / kg and 300 mg / kg.

[0045] Advantageously, mass concentrations within these ranges make it possible to administer an effective dose of 2-methyloxolane to the animal while still ingesting an acceptable amount of the biological substrate cake.

[0046] In another aspect, there is provided a dietary supplement for feeding egg-laying animals, particularly pheasants, more particularly chickens, said dietary supplement comprising 2-methyloxolane.

[0047] The dietary supplement may be in the form of a solution, powder, capsule, extrudate, tablet, or biological matrix cake, particularly a powder, capsule, or biological matrix cake, more particularly a biological matrix cake.

[0048] In the dietary supplement, the 2-methyloxolane may be in liquid form or may be impregnated onto a food-grade carrier for egg-laying animals in the dietary supplement.

[0049] For example, 2-methyloxolane in liquid form is suitable for dietary supplements in the form of solutions and capsules, and impregnation of 2-methyloxolane is suitable for dietary supplements in the form of powders, extrudates, tablets, or cakes of biological substrates.

[0050] These formats are easy to produce because they are well known to those skilled in the art, and 2-methyloxolane is a liquid under atmospheric pressure and temperature conditions, so it can be easily impregnated onto a food-grade carrier by known techniques.

[0051] For example, the food-grade carrier of the dietary supplement can be selected from a mineral carrier or a biological carrier. For example, the mineral carrier can be a mineral powder, such as silica powder. Tixosil® 68 powder is an example of a silica powder suitable for use as a mineral carrier.

[0052] As defined herein above, biological substrate cake is the solid residue of the extraction of oil or juice from a biological substrate, which is a solid material selected from plants, algae, microorganisms, and mixtures thereof, in particular plants.

[0053] For example, the plant may be an oleaginous plant, a proteaginous plant, or a mixture thereof.

[0054] As oleaginous plants, mention may be made of rapeseed, sunflower, soybean, peanut, sesame, walnut, almond, cotton, linseed or mixtures thereof, in particular rapeseed, sunflower, soybean or mixtures thereof.

[0055] Examples of proteaginous plants include peas, beans, lupines, and mixtures thereof.

[0056] Typically, biological substrates include almonds, amaranth, peanuts, argan, sea buckthorn, cashew trees, avocados, oats, borage, safflower, camelina, carrots, cocao, cashews, canola, hemp, rapeseed, copra, mallow, cotton, croton, rosehips, figs, prickly pear, pomegranate, hops, illipe, jojoba, jasmine, shea trees, lavender, lavandin, linseed, lupin, corn, hazel trees, walnuts, coconuts, Poppy, olive, evening primrose, orange tree, oil palm, paprika, pecan, pistachio, pepper, castor, rice, rose, cedar rose, musk rose, sesame, soybean, marigold, sunflower, calabash, moix, macadamia nut, raspberry, black currant, melon, grape, tomato, baobab, babassu, cranberry, chia, pumpkin, mustard, neem, nigella, niger, poppy, perilla, Plukenetia volvilli volubili), winter squash, annatto, tarramilla, apricot, plum, peach, wheat, moonflower, ylang-ylang, geranium, patchouli, petitgrain (citrus), anise, caraway, juniper, bergamot, mandarin orange, grapefruit, lemon, nutmeg tree, celery, angelica, cardamom, cumar, vanilla, vetiver, iris, sandalwood, hollyhock, tarragon, citronellol The plant may be selected from among nera, sage, mint, pine tree, rosemary, fir tree, thyme, galbanum, elemi, benzoin, myrrh, olibanum tree, and mixtures thereof, in particular soybean, rapeseed, sunflower, baobab, corn, peanut, coconut, oil palm, cotton, and mixtures thereof, more particularly soybean, rapeseed, sunflower, baobab, and mixtures thereof.

[0057] In certain embodiments, the biological substrate cake is a cake of soybean, rapeseed, sunflower, corn, peanut, and mixtures thereof.

[0058] The biological substrate cake may be in the form of a cake or an extrudate powder.

[0059] Advantageously, cake flour is easy to eat and very well digested by oviparous animals.

[0060] The cake of the biological substrate may be obtained from a process for producing oil by solid / liquid extraction using 2-methyloxolane. Such a process is described, for example, in European Patent Application No. 19 842 832.3.

[0061] Typically, the mass concentration of 2-methyloxolane in the cake of the biological substrate may be less than 1,000 mg / kg, in particular between 10 mg / kg and 500 mg / kg, more particularly between 100 mg / kg and 300 mg / kg.

[0062] Advantageously, mass concentrations within these ranges allow for the administration of an effective dose of 2-methyloxolane to the animal while still allowing the animal to ingest an acceptable amount of the biological substrate cake.

[0063] The dietary supplement may be fed by the egg-laying animal as a supplement to its conventional feeding, for example as a supplement to grains.

[0064] Therefore, in another aspect, there is provided the use of a kit for increasing egg production in oviparous animals, in particular pheasants, more particularly chickens, said kit comprising: a dietary supplement comprising 2-methyloxolane as described herein above; Composition for feeding egg-laying animals, in particular pheasants, more particularly chickens - Patent 7222447 Includes:

[0065] Typically, when using the present kit, the amount of 2-methyloxolane administered to oviparous animals, particularly pheasants, more particularly chickens, may be comprised between 0.1 and 200 mg / kg oviparous animals / day, particularly between 1 and 50 mg / kg oviparous animals / day, more particularly between 3 and 32 mg / kg oviparous animals / day.

[0066] Advantageously, egg production of oviparous animals is increased when the amount of 2-methyloxolane taken up by said oviparous animals is administered within these ranges.

[0067] For example, the composition for feeding oviparous animals of the kit used may be grains such as wheat, corn, oats, and mixtures thereof; Food waste such as fruit and / or plant peels, and / or complete food Especially complete foods It could be.

[0068] In the context of the present application, a "complete food" refers to a complex food that is nutritionally suitable for an oviparous animal due to its specific composition and designed to form a specific ration capable of keeping the oviparous animal alive and / or promoting egg production.

[0069] The whole food may be in the form of an extrudate, granules, powder, or pellets.

[0070] In another aspect, there is provided a kit for feeding egg-laying animals, particularly pheasants, more particularly chickens, said kit comprising: a dietary supplement comprising 2-methyloxolane as described herein above; Composition for feeding egg-laying animals, in particular pheasants, more particularly chickens - Patent 7222447 Includes.

[0071] For example, the composition for feeding animals in the kit may include: grains such as wheat, corn, oats, and mixtures thereof; Food waste such as fruit and / or plant peels, and / or complete food Especially complete foods It could be.

[0072] The whole food may be in the form of an extrudate, granules, powder, or pellets.

[0073] The dietary supplements and compositions for feeding animals, in particular complete feeds, may form foods intended to be fed to egg-laying animals, in particular pheasants, and more particularly chickens.

[0074] Thus, in another aspect, there is provided the use of a food product for increasing egg production in oviparous animals, particularly pheasants, more particularly chickens, said food product comprising a dietary supplement comprising 2-methyloxolane as described herein above and a composition for feeding oviparous animals, particularly pheasants, more particularly chickens, as described herein above.

[0075] In the context of the present application, "food" refers to a composition that, due to its specific composition, is suitable from a nutritional point of view for an oviparous animal and is designed to form a specific ration that can keep the oviparous animal alive and / or promote egg production.

[0076] Advantageously, the food used is easy to implement by breeders, as it allows feeding specific rations to oviparous animals in order to increase their egg production.

[0077] Typically, the amount of 2-methyloxolane administered to oviparous animals, in particular pheasants, more particularly chickens, when using this food product may be comprised between 0.1 and 200 mg / kg oviparous animal / day, in particular between 1 and 50 mg / kg oviparous animal / day, more particularly between 3 and 32 mg / kg oviparous animal / day.

[0078] Advantageously, egg production of oviparous animals is increased when the amount of 2-methyloxolane taken up by said oviparous animals is administered within these ranges.

[0079] In another aspect, there is provided a food product for feeding oviparous animals, particularly pheasants, more particularly chickens, said food product comprising a dietary supplement comprising 2-methyloxolane as described herein above and a composition for feeding oviparous animals, particularly pheasants, more particularly chickens, as described herein above.

[0080] The food product may be in the form of an extrudate, granules, powder, or pellets.

[0081] Foods include: a1) mixing the dietary supplement and the composition for feeding animals to obtain a mixture; b1) shaping the mixture obtained in step a) to produce a food product. It can be produced by a method comprising:

[0082] Steps a1) and b1) are conventional steps that can be easily performed by a person skilled in the art.

[0083] This production method is suitable for food products in the form of extrudates, granules, powders or pellets.

[0084] Alternatively, the food may be: a2) grinding the dietary supplement to obtain a first powder; b2) grinding the composition for feeding animals to obtain a second powder; c2) mixing the first powder and the second powder to produce a food product. It can be produced by a method comprising:

[0085] Steps a2), b2) and c2) are conventional steps that can be easily performed by a person skilled in the art.

[0086] This alternative production method is suitable for food products in powder form.

[0087] In another aspect, there is provided a dietary supplement as described herein above, a kit as described herein above, or a food product as described herein above for use thereof in increasing egg production in oviparous animals, particularly pheasants, more particularly chickens.

[0088] Typically, the amount of 2-methyloxolane administered to oviparous animals, in particular pheasants, more particularly chickens, by a dietary supplement, kit or food for this use may be comprised between 0.1 and 200 mg / kg oviparous animal / day, in particular between 1 and 50 mg / kg oviparous animal / day, more particularly between 3 and 32 mg / kg oviparous animal / day.

[0089] Advantageously, egg production of oviparous animals is increased when the amount of 2-methyloxolane taken up by said oviparous animals is administered within these ranges.

[0090] In another aspect, there is provided a method for increasing egg production in an oviparous animal, in particular a pheasant, more particularly a chicken, comprising the step of ingestion by said oviparous animal, in particular a pheasant, more particularly a chicken, of a dietary supplement as described herein above, a kit as described herein above, or a food product as described herein above.

[0091] Typically, during this method the amount of 2-methyloxolane administered to oviparous animals, in particular pheasants, more particularly chickens, may be comprised between 0.1 and 200 mg / kg oviparous animal / day, in particular between 1 and 50 mg / kg oviparous animal / day, more particularly between 3 and 32 mg / kg oviparous animal / day.

[0092] Advantageously, egg production of oviparous animals is increased when the amount of 2-methyloxolane taken up by said oviparous animals is administered within these ranges.

[0093] Example The following examples make it possible to illustrate the invention without limiting it.

[0094] In this example, domestic egg-laying hens are divided into four groups: The four chickens in the control group did not receive 2-methyloxolane. The 12 chickens in the Nx1 group received pure liquid 2-methyloxolane in capsules. The ingested dose of pure liquid 2-methyloxolane was 3.18 mg / kg chicken, or a daily ration of 40 mg / kg. Twelve chickens in the Nx5 group received pure liquid 2-methyloxolane in capsules. The ingested dose of pure liquid 2-methyloxolane was 15.88 mg / kg chicken, or a daily ration of 200 mg / kg. Twelve chickens in group Nx10 received pure liquid 2-methyloxolane in capsules. The ingested dose of pure liquid 2-methyloxolane was 31.77 mg / kg chicken, i.e., a daily quota of 400 mg / kg (group Nx10).

[0095] Egg production in each group was monitored to statistically test the significance of the effect of oral administration of 2-methyloxolane on egg production.

[0096] The statistical process is as follows: One-way analysis of variance (ANOVA) was performed using XLSTAT 2020.2.1 in MS EXCEL 16.0.15225. The significance threshold was 95% with a p-value of 0.05 to verify a significant effect of oral administration of 2-methyloxolane on egg production. Discrete explanatory variable: basking group. Continuous variable explained: fecundity was used.

[0097] In case of significant differences between means, Student's t-test at a significance level of 5% is applied for pairwise comparisons using the same software.

[0098] In total, 1115 eggs were counted during this observation.

[0099] Table 1 herein below presents the average number of eggs laid per day by four hens as a function of basking group.

[0100] [Table 1]

[0101] Student's t-test for two groups: a control group, and Oral administration of 2-methyloxolane clearly indicates the existence of

[0102] Therefore, this example shows that oral administration of 2-methyloxolane significantly increases the number of eggs produced per chicken in the range tested, i.e., 40-400 mg / kg of 2-methyloxolane per day, without any apparent dose effect.

Claims

1. Use of a dietary supplement containing 2-methyloxolane to increase egg production in oviparous animals.

2. 2. The use of claim 1, wherein the amount of 2-methyloxolane administered to the oviparous animal is comprised between 0.1 mg / kg of oviparous animal / day and 200 mg / kg of oviparous animal / day.

3. 3. The use according to claim 1 or 2, wherein the dietary supplement is in the form of a solution, powder, capsule, extrudate, tablet or is a cake of biological matrix.

4. The use according to any one of claims 1 to 3, wherein the dietary supplement is a biological matrix cake.

5. 5. The use according to claim 4, wherein the biological substrate cake is in the form of cake or extrudate powder.

6. The biological substrate may be selected from the group consisting of almond, amaranth, peanut, argan, sea buckthorn, cashew tree, avocado, oats, borage, safflower, camelina, carrot, cocao, cashew, canola, hemp, rapeseed, copra, mallow, cotton, croton, rosehip, fig, prickly pear, pomegranate, hops, illipe, jojoba, jasmine, shea tree, lavender, lavandin, linseed, lupin, corn, hazel tree, walnut, coconut, ke Chestnut, olive, evening primrose, orange tree, oil palm, paprika, pecan, pistachio, pepper, castor, rice, rose, cedar rose, musk rose, sesame, soybean, marigold, sunflower, calabash, moix, macadamia nut, raspberry, black currant, melon, grape, tomato, baobab, babassu, cranberry, chia, pumpkin, mustard, neem, nigella serrata, niger, poppy, perilla, Plukenetia volvilli volubili), winter squash, annatto, tarramilla, apricot, plum, peach, wheat, moonflower, ylang-ylang, geranium, patchouli, petitgrain (citrus), anise, caraway, juniper, bergamot, mandarin orange, grapefruit, lemon, nutmeg tree, celery, angelica, cardamom, cumar, vanilla, vetiver, iris, sandalwood, holly tree, tarragon, citronella, sage, mint, pine tree, rosemary, fir tree, thyme, galbanum, elemi, benzoin, myrrh, olibanum tree and mixtures thereof.

7. Use of a kit for increasing egg production in an oviparous animal, said kit comprising: A dietary supplement containing 2-methyloxolane as used in any one of claims 1 to 6; A composition for feeding oviparous animals; Including, use.

8. 8. The use of claim 7, wherein the amount of 2-methyloxolane administered to the oviparous animal is comprised between 0.1 mg / kg of oviparous animal / day and 200 mg / kg of oviparous animal / day.

9. Use of a food product for increasing egg production in an oviparous animal, the composition comprising: A dietary supplement as used in any one of claims 1 to 6; A composition for feeding oviparous animals; Including, use.

10. 10. The use of claim 9, wherein the amount of 2-methyloxolane administered to the oviparous animal is comprised between 0.1 mg / kg of oviparous animal / day and 200 mg / kg of oviparous animal / day.

11. A dietary supplement for feeding oviparous animals, the dietary supplement comprising 2-methyloxolane.

12. A kit for feeding oviparous animals, comprising: A dietary supplement according to claim 11; A composition for feeding oviparous animals; Includes a kit.

13. 12. A food product intended to be fed to oviparous animals, comprising the dietary supplement of claim 11 and a composition for feeding oviparous animals.