Formula for herbal feminine care solution and preparation method thereof

Abstract

The present invention provides a formula for a traditional Chinese medicine-based feminine care solution and its preparation method. The care solution consists of, by weight, 10-15 parts rose hydrosol, 3-5 parts mint hydrosol, 30-45 parts traditional Chinese medicine extract, 3-5 parts dipterocarpus, 1-5 parts chelated platinum ion, and 6-12 parts bacteriostatic agent. The preparation method involves adding the rose hydrosol and mint hydrosol to the traditional Chinese medicine extract to obtain a concentrate. The concentrate is then diluted, and the dipterocarpus is added. The mixture is thoroughly stirred and filtered to obtain a filtrate. The chelated platinum ion and bacteriostatic agent are then added and stirred uniformly.

Description

[Technical Field]

[0001] The present invention relates to the field of feminine hygiene care, and more particularly to the formulation of herbal feminine care solutions and the preparation method thereof. [Background technology]

[0002] Modern women face increasing social responsibilities and stress, forcing them to live hectic lives. Furthermore, they spend a large portion of their time in the office, commuting to and from work, traveling, and spending more time in public places, increasing the risk of infection in public settings. According to relevant data, approximately 85% of adult women worldwide suffer from gynecological inflammation to varying degrees, with 46% of these patients experiencing recurrences. Furthermore, the incidence of vaginitis is trending toward younger women, with 53.9% of students experiencing vaginitis-related symptoms. Among these, bacterial vaginosis accounts for the majority (35.9%), followed by candidal vaginitis (23.6%). Therefore, daily bacteriostatic and cleansing care is particularly important for reducing the incidence of gynecological inflammation.

[0003] Feminine care solutions are also called vaginal washes or feminine antibacterial washes. They are used by women to cleanse and eliminate unpleasant odors and treat gynecological inflammation, thereby killing pathogenic microorganisms and disinfecting the genital area. In fact, men can also use them to disinfect and sterilize the genital area. In the Chinese market, existing feminine care solutions are divided into health care types, which are refined with natural lactic acid and herbal plants as their main ingredients, and over-the-counter (OTC) drug types, which use traditional Chinese medicine as their main ingredient.

[0004] Conventional feminine care solutions are typically feminine douches or rinses, and include cleansing care / maintenance types, antibacterial / bacteriostatic douches, and treatment douches. Cleansing care / maintenance types are primarily used by women to cleanse the genital area daily during normal vaginal secretions and discharges, and are often referred to as care / maintenance solutions or feminine care solutions. Antibacterial / bacteriostatic douches, as the name suggests, are primarily used for antibacterial and bacteriostatic purposes in the female genital area. Treatment douches are used by women when they are infected with various types of vaginitis, and examples include Jie'eryin douche, Huangku douche, and Jolly vaginal douche.

[0005] Patent Document 1 discloses a herbal care solution for women's menstrual and daily use for vaginal contraction, sterilization, and antipruritic relief. The care solution consists of 10-30 grams each of Tuber Root Bark, Thousand Li Guang, Snake Seeds, Diphagnum Zi, White Moss Bark, and Golden Flower, 5-20 grams each of Sophora Radix, Baibing, Scutellaria Baicalensis, White Root, Cornus Cherry, Pomegranate Bark, Gall Seed, Greenwood Root, Lulu Tong, Chinese Gallnut, Moutan Bark, and Angelica Root, and 5-10 grams each of Asarum, Sichuan Pepper, and Garlic. The above herbal medicine is soaked in an alcoholic aqueous solution, and the supernatant is extracted by reflux extraction. Then, 60-80 grams of herbal extract, 3-5 grams of disinfectant, 1-2 grams of moisturizer, 1-2 grams of natural anti-allergy agent, 0.5-1 gram of complexing agent (alum burnt), and 0.3-0.5 grams of fragrance are mixed together, and the supernatant is separated by complexation and sedimentation. However, this care solution does not have good bacteriostatic or antibacterial effects in actual use, and is not widely applicable. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Chinese Patent Application No. 200610032397.8 Summary of the Invention [Problem to be solved by the invention]

[0007] In order to overcome the deficiencies of the prior art, the object of the present invention is to provide a formula and a preparation method for a traditional Chinese medicine feminine care solution that has excellent bactericidal effect, can effectively cleanse, bactericidalize, relieve itching, remove odors, and prevent inflammation of the female vulva, and has no side effects on the human body. [Means for solving the problem]

[0008] In order to achieve the above object, the present invention employs the following technical means.

[0009] The formula for the herbal feminine care solution consists of, by weight, 10-15 parts rose hydrosol, 3-5 parts mint hydrosol, 30-45 parts herbal extract, 3-5 parts dipterocarpus, 1-5 parts chelated platinum ions, and 6-12 parts bacteriostatic agent.

[0010] The method for preparing the bacteriostatic agent includes the following steps:

[0011] (1) After dispersing nano-silicon dioxide in an ethanol solution, ammonia water and (3-mercaptopropyl)trimethoxysilane are added and stirred to cause a reaction. The product is then centrifuged, washed, and dried to obtain thiolated silicon dioxide.

[0012] (2) Dodecafluoroheptyl methacrylate and vinyl guanamine are added to N,N-dimethylformamide and stirred uniformly to obtain a mixed solution. Then, thiolated silicon dioxide is dispersed in the mixed solution and ultrasonically dispersed. A photoinitiator is added and then the solution is reacted by irradiating with ultraviolet light. The product is then centrifuged, washed with isopropanol, and dried to obtain the bacteriostatic agent.

[0013] Preferably, in step (1), the concentration of the aqueous ethanol solution is 50 to 75 wt %, and the concentration of the aqueous ammonia is 15 to 25 wt %.

[0014] Preferably, in step (1), the weight ratio of nano silicon dioxide, aqueous ethanol solution, aqueous ammonia, and (3-mercaptopropyl)trimethoxysilane is 10:50-70:8-17:3-6.

[0015] Preferably, in step (1), the reaction conditions are a N2 atmosphere at 20 to 35°C for 5 to 8 hours.

[0016] Preferably, in step (2), the weight ratio of dodecafluoroheptyl methacrylate, vinyl guanamine, N,N-dimethylformamide, and thiolated silicon dioxide is 2-5:4-7:30-50:10.

[0017] Preferably, in step (2), the photoinitiator is one or more of benzoin dimethyl ether, benzoin ethyl ether, benzoin butyl ether.

[0018] Preferably, in step (2), the ultrasonic dispersion time is 5 to 15 minutes, the main wavelength of the ultraviolet light is 360 to 365 nm, and the ultraviolet light intensity is 50 to 100 mW / cm. 2 The irradiation time is 30 to 60 minutes, and the reaction temperature is 30 to 40°C.

[0019] Preferably, the method for preparing the herbal extract comprises the following steps: 1-2 parts safflower, 8-12 parts peach kernel, 8-12 parts forsythia, 8-13 parts chrysanthemum, 7-13 parts perilla, 18-25 parts platycodon, 8-11 parts star anise, 9-14 parts serrano serrano, 7-12 parts cuckoo root, 10-12 parts sophora rhizome, 10-12 parts white atractylodes, 9-13 parts green peel, 10-12 parts clove fragrans, 4-6 parts Sichuan pepper, and 13-16 parts tea leaves are weighed into a reaction vessel, added to the vessel, and distilled at 94-97°C for 1.5-3 hours to obtain the herbal extract.

[0020] The present invention also claims a method for preparing the formula for the herbal feminine care solution. The method includes the following steps: add rose hydrosol and mint hydrosol to a traditional Chinese medicine extract to obtain a stock solution; dilute the stock solution, add dipterocarp, stir thoroughly, and filter to obtain a filtrate; add chelated platinum ions and a bacteriostatic agent, and stir evenly to obtain the herbal feminine care solution.

[0021] Preferably, the dilution ratio of the stock solution is 10 to 20 times. [Effects of the Invention]

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] Safflower: Improves menstrual irregularities by promoting blood circulation and relieves pain by eliminating blood stasis. This contributes to the therapeutic effects on menstrual irregularities, menstrual pain, abnormal discharge, chest pain, abdominal pain due to congestion, chest and flank pain, injuries, and swelling and pain from ulcers.

[0024] Peach kernel: It has the effect of promoting blood circulation to relieve blood congestion, moistening the intestines to promote bowel movements, suppressing coughs, and improving asthma. It is effective for menstrual irregularities and menstrual pain, intraperitoneal lumps, lung abscesses and appendicitis, trauma, constipation due to dry intestines, coughs, and asthma.

[0025] Forsythia: Helps clear heat, detoxify, eliminate lumps, and relieve swelling and edema. It is used to treat fever, erysipelas, rashes, abscesses, swelling, scrofula, and difficulty urinating.

[0026] Chrysanthemum: Helps relieve the initial symptoms of colds, clears fever, improves eyesight, and detoxifies. It is used to treat headaches, dizziness, bloodshot eyes, chest fever, boils, sores, and swelling.

[0027] Perilla: The leaves are diaphoretic, antitussive, aromatic stomachic, diuretic, analgesic, sedative, and detoxifying, helping to treat colds. The stems have a calming effect and stabilize the fetus. The seeds are antitussive, expectorant, improve asthma, and relieve stress.

[0028] Platycodon: Improves lung function, soothes the throat, expels phlegm, and helps drain pus. This is used in cases of excessive cough and phlegm, shortness of breath, sore throat, hoarseness, drainage of pus from lung abscesses, and ulcers that are filled with pus but not burst.

[0029] Star anise: Has a warming effect on the body and a pungent taste. It has the effect of warming the body and expelling cold, as well as regulating the flow of qi and relieving pain. It is used to treat symptoms such as vomiting due to cold, abdominal pain due to cold, lower back pain associated with kidney deficiency, and dry and wet athlete's foot.

[0030] Wood Fragrance: Improves the flow of energy, relieves pain, regulates the stomach and intestines, and aids digestion. Effective for chest and stomach distension and pain, diarrhea, heaviness after a stomach ulcer, indigestion, and loss of appetite.

[0031] Cuckoo: Helps restore vital energy, regulates the stomach and intestines, removes impurities, and expels fluids. It is used to treat colds, heat and dampness, headaches, chest and stomach bloating, vomiting, diarrhea, malaria, dysentery, and bad breath.

[0032] Soujutsu: Regulates the stomach and intestines, removes dampness, relieves depression, and removes impurities. It is used to treat digestive disorders caused by fluid retention, drowsiness due to fatigue, stomach and abdominal bloating, loss of appetite, vomiting, diarrhea, dysentery, malaria, phlegm, edema, seasonal influenza, pain and numbness caused by cold and humidity, weakness of the lower limbs, and night blindness.

[0033] Atractylodes Root: Improves gastrointestinal function, eliminates dampness, regulates the stomach and intestines, and stabilizes the fetus. It is used to treat poor digestion, loss of appetite, fatigue and shallow breathing, abdominal distension due to qi deficiency, diarrhea, phlegm, edema, jaundice, pain and numbness due to dampness, difficulty urinating, dizziness, spontaneous sweating, and pregnancy disorders.

[0034] Qingpi: Removes stagnation of liver qi and relieves gastrointestinal congestion. It is effective for chest and flank swelling and pain, hernia, breast tuberculosis, mastitis, and abdominal pain caused by overeating.

[0035] Cingoliferous: Warms the stomach and intestines, warms the kidneys, and lowers Qi. It is used to treat hiccups, vomiting, nausea, diarrhea, chest and abdominal pain associated with cold, lumps in the abdomen and flanks, hernias, and psoriasis.

[0036] Sichuan pepper: warms the stomach and intestines and removes cold. It also helps to dehumidify, relieve pain, kill insects, and remove fishy odors. It is used to treat indigestion and water retention, chest and abdominal pain associated with cold, vomiting, belching, coughing, and irritation, pain and numbness caused by cold and dampness, diarrhea, dysentery, colic, toothache, ascariasis, pinworm infestation, genital itching, and scabies.

[0037] Tea leaves: Helps to clear heat from the head and eyes, relieve dry mouth, expectorate, aid digestion, diuretic, and detoxify. It is used to treat headaches, blurred vision, excessive sleepiness, irritability and dry mouth, indigestion and phlegm congestion, malaria, and diarrhea.

[0038] Dipterocarpus: Used for impaired consciousness, clouding of consciousness, bloodshot, swollen and painful eyes, sore throat, and stomatitis. Also used for swelling and pain from ulcers, poor prognosis after collapse, and angina pectoris.

[0039] 1) The present invention discloses a traditional Chinese medicine feminine care solution. Formulated from botanical ingredients with anti-inflammatory, antioxidant, allergy-preventing, infection-reducing, and immune-boosting effects, a complex antibacterial component, and chelated platinum ions that enhance the performance of the herbal medicine through catalytic action, the care solution effectively cleanses the female vulva and provides benefits such as nourishment, odor elimination, anti-itching, allergy prevention, and bacteriostasis, while also effectively moisturizing and protecting the skin of the female genital area. Furthermore, application can be achieved by spraying, eliminating the need for conventional water washing or rinsing methods, making it convenient and quick.

[0040] 2) The present invention provides a bacteriostatic agent. First, nano-silicon dioxide is organically modified with (3-mercaptopropyl)trimethoxysilane to obtain thiolated silicon dioxide. This effectively improves the dispersibility of nano-silicon dioxide, preventing it from flocculating and settling in the care solution. Next, dodecafluoroheptyl methacrylate and vinyl guanamine are grafted onto the thiolated silicon dioxide through a thiol-ene reaction under ultraviolet irradiation to obtain a bacteriostatic agent. Because vinyl guanamine has a positive charge in water, it adsorbs to the negatively charged surface of microorganisms, allowing it to penetrate into the microorganisms. It then inactivates bacteria and viruses by disrupting the normal metabolic processes of the microorganisms. Furthermore, vinyl guanamine is virtually non-toxic to normal eukaryotic cells, making it safe and non-toxic to the human body. Furthermore, it does not induce drug resistance in bacteria, thereby providing excellent antibacterial activity. Furthermore, dodecafluoroheptyl methacrylate has excellent hydrophobicity, which can prevent the initial adhesion of bacteria and proteins and inhibit the formation of biofilms, thereby exerting an inhibitory and killing effect on bacteria in cooperation with vinylguanamine. DETAILED DESCRIPTION OF THE INVENTION

[0041] In order to clarify the objectives, technical means and advantages of the present invention, the present invention will be described in more detail below using examples. It should be understood that the specific examples described here are merely for the purpose of illustrating the present invention and are not intended to limit the present invention.

[0042] Unless otherwise specified, all chemical reagents and materials used in the present invention were either commercially available or synthesized from commercially available raw materials.

[0043] The particle size of nano silicon dioxide is 75-120 nm.

[0044] Both rose hydrosol and mint hydrosol were purchased from Guangzhou Zhonghe International Biotechnology Co., Ltd.

[0045] Chelated platinum ions were purchased from Yatian Technology Group.

[0046] The present invention will be further described below with reference to specific examples. [Example]

[0047] The preparation method of the herbal feminine care solution included the following steps:

[0048] (1) 10 g of nano-silicon dioxide was dispersed in 70 g of 75 wt% aqueous ethanol solution, and then 17 g of 20 wt% aqueous ammonia and 6 g of (3-mercaptopropyl)trimethoxysilane were added. The mixture was stirred at 35°C for 8 hours in a N2 atmosphere. The product was then centrifuged, washed, and dried to obtain thiolated silicon dioxide.

[0049] (2) 5 g of dodecafluoroheptyl methacrylate and 7 g of vinyl guanamine were added to 50 g of N,N-dimethylformamide and stirred to obtain a mixed solution. 10 g of thiolated silicon dioxide was then dispersed in the mixed solution, followed by ultrasonic dispersion for 15 minutes. 0.2 g of benzoin ethyl ether was then added, followed by ultrasonic dispersion at a dominant wavelength of 365 nm and an intensity of 100 mW / cm. 2 The mixture was irradiated with ultraviolet light at 40°C for 60 minutes, and the reaction mixture was centrifuged, washed with isopropanol, and dried to obtain a bacteriostatic agent.

[0050] (3) 2g of safflower, 10g of peach kernel, 10g of forsythia, 11g of chrysanthemum, 10g of shiso, 22g of bellflower, 9g of star anise, 12g of wood spices, 8g of cuckoo root, 11g of soju, 11g of white atractylodes, 11g of rhododendron bark, 11g of clove spices, 5g of Sichuan pepper, and 15g of tea leaves were weighed and placed in a reaction vessel. 500g of deionized water was added, and the mixture was distilled at 96°C for 2.5 hours to obtain a Chinese herbal extract.

[0051] (4) 15g of rose hydrosol and 5g of mint hydrosol were added to 45g of herbal extract to obtain a stock solution. Next, the stock solution was diluted 20 times, and 5g of dipterocarpus was added. After thorough stirring, the filtrate was obtained. 5g of chelated platinum ions and 12g of bacteriostatic agent were added, and the mixture was stirred uniformly to obtain a herbal feminine care solution. [Example]

[0052] The preparation method of the herbal feminine care solution included the following steps:

[0053] (1) 10 g of nano-silicon dioxide was dispersed in 60 g of 75 wt% aqueous ethanol solution, and then 12 g of 20 wt% aqueous ammonia and 5 g of (3-mercaptopropyl)trimethoxysilane were added. The mixture was stirred at 30°C for 6 hours in a N2 atmosphere. The product was then centrifuged, washed, and dried to obtain thiolated silicon dioxide.

[0054] (2) 4 g of dodecafluoroheptyl methacrylate and 5 g of vinyl guanamine were added to 40 g of N,N-dimethylformamide and stirred uniformly to obtain a mixed solution. Then, 10 g of thiolated silicon dioxide was dispersed in the mixed solution, and ultrasonic dispersion was performed for 10 minutes. 0.2 g of benzoin ethyl ether was added, and the mixture was then dispersed at a dominant wavelength of 365 nm and an intensity of 100 mW / cm. 2 The mixture was irradiated with ultraviolet light at 35°C for 50 minutes, and the reaction mixture was then centrifuged, washed with isopropanol, and dried to obtain the bacteriostatic agent.

[0055] (3) 2g of safflower, 10g of peach kernel, 10g of forsythia, 11g of chrysanthemum, 10g of shiso, 22g of bellflower, 9g of star anise, 12g of wood spices, 8g of cuckoo root, 11g of soju, 11g of white atractylodes, 11g of rhododendron bark, 11g of clove spices, 5g of Sichuan pepper, and 15g of tea leaves were weighed and placed in a reaction vessel. 500g of deionized water was added, and the mixture was distilled at 96°C for 2.5 hours to obtain a Chinese herbal extract.

[0056] (4) 12g of rose hydrosol and 4g of mint hydrosol were added to 40g of herbal extract to obtain a stock solution. Next, the stock solution was diluted 20 times, and 4g of dipterocarpus was added. After thorough stirring, the filtrate was obtained. 3g of chelated platinum ions and 9g of bacteriostatic agent were added, and the mixture was stirred uniformly to obtain a herbal feminine care solution. [Example]

[0057] The preparation method of the herbal feminine care solution included the following steps:

[0058] (1) 10 g of nano-silicon dioxide was dispersed in 50 g of 75 wt% ethanol aqueous solution, and then 8 g of 20 wt% ammonia water and 3 g of (3-mercaptopropyl)trimethoxysilane were added. The mixture was stirred at 20°C for 5 hours in a N2 atmosphere. The product was then centrifuged, washed, and dried to obtain thiolated silicon dioxide.

[0059] (2) 2 g of dodecafluoroheptyl methacrylate and 4 g of vinyl guanamine were added to 30 g of N,N-dimethylformamide and stirred uniformly to obtain a mixed solution. Then, 10 g of thiolated silicon dioxide was dispersed in the mixed solution, and ultrasonic dispersion was performed for 5 minutes. 0.2 g of benzoin ethyl ether was added, and the mixture was then dispersed at a dominant wavelength of 365 nm and an intensity of 100 mW / cm. 2 The mixture was irradiated with ultraviolet light at 30° C. for 30 minutes, and the reaction was carried out at 30° C. Then, the product was centrifuged, washed with isopropanol, and dried to obtain a bacteriostatic agent.

[0060] (3) 2g of safflower, 10g of peach kernel, 10g of forsythia, 11g of chrysanthemum, 10g of shiso, 22g of bellflower, 9g of star anise, 12g of wood spices, 8g of cuckoo root, 11g of soju, 11g of white atractylodes, 11g of rhododendron bark, 11g of clove spices, 5g of Sichuan pepper, and 15g of tea leaves were weighed and placed in a reaction vessel. 500g of deionized water was added, and the mixture was distilled at 96°C for 2.5 hours to obtain a Chinese herbal extract.

[0061] (4) 10g of rose hydrosol and 3g of mint hydrosol were added to 30g of herbal extract to obtain a stock solution. Next, the stock solution was diluted 20 times, and 3g of dipterocarpus was added. After thorough stirring, the filtrate was obtained. 1g of chelated platinum ion and 6g of bacteriostatic agent were added, and the mixture was stirred uniformly to obtain a herbal feminine care solution.

[0062] (Comparative Example 1) The preparation method of the herbal feminine care solution included the following steps:

[0063] (1) 10 g of nano-silicon dioxide was dispersed in 70 g of 75 wt% aqueous ethanol solution, and then 17 g of 20 wt% aqueous ammonia and 6 g of (3-mercaptopropyl)trimethoxysilane were added. The mixture was stirred at 35°C for 8 hours in a N2 atmosphere. The product was then centrifuged, washed, and dried to obtain thiolated silicon dioxide.

[0064] (2) 5 g of dodecafluoroheptyl methacrylate was added to 50 g of N,N-dimethylformamide and stirred to obtain a mixed solution. 10 g of thiolated silicon dioxide was then dispersed in the mixed solution, followed by ultrasonic dispersion for 15 minutes. 0.2 g of benzoin ethyl ether was then added, followed by ultrasonic dispersion at a dominant wavelength of 365 nm and an intensity of 100 mW / cm. 2 The mixture was irradiated with ultraviolet light at 40°C for 60 minutes, and the reaction mixture was centrifuged, washed with isopropanol, and dried to obtain a bacteriostatic agent.

[0065] (3) 2g of safflower, 10g of peach kernel, 10g of forsythia, 11g of chrysanthemum, 10g of shiso, 22g of bellflower, 9g of star anise, 12g of wood spices, 8g of cuckoo root, 11g of soju, 11g of white atractylodes, 11g of rhododendron bark, 11g of clove spices, 5g of Sichuan pepper, and 15g of tea leaves were weighed and placed in a reaction vessel. 500g of deionized water was added, and the mixture was distilled at 96°C for 2.5 hours to obtain a Chinese herbal extract.

[0066] (4) 15g of rose hydrosol and 5g of mint hydrosol were added to 45g of herbal extract to obtain a stock solution. Next, the stock solution was diluted 20 times, and 5g of dipterocarpus was added. After thorough stirring, the filtrate was obtained. 5g of chelated platinum ions and 12g of bacteriostatic agent were added, and the mixture was stirred uniformly to obtain a herbal feminine care solution.

[0067] (Comparative Example 2) The preparation method of the herbal feminine care solution included the following steps:

[0068] (1) 10 g of nano-silicon dioxide was dispersed in 70 g of 75 wt% aqueous ethanol solution, and then 17 g of 20 wt% aqueous ammonia and 6 g of (3-mercaptopropyl)trimethoxysilane were added. The mixture was stirred at 35°C for 8 hours in a N2 atmosphere. The product was then centrifuged, washed, and dried to obtain thiolated silicon dioxide.

[0069] (2) 7 g of vinylguanamine was added to 50 g of N,N-dimethylformamide and stirred to obtain a mixed solution. 10 g of thiolated silicon dioxide was then dispersed in the mixed solution, followed by ultrasonic dispersion for 15 minutes. 0.2 g of benzoin ethyl ether was then added, followed by ultrasonic dispersion at a dominant wavelength of 365 nm and an intensity of 100 mW / cm. 2 The mixture was irradiated with ultraviolet light at 40°C for 60 minutes, and the reaction mixture was centrifuged, washed with isopropanol, and dried to obtain a bacteriostatic agent.

[0070] (3) 2g of safflower, 10g of peach kernel, 10g of forsythia, 11g of chrysanthemum, 10g of shiso, 22g of bellflower, 9g of star anise, 12g of wood spices, 8g of cuckoo root, 11g of soju, 11g of white atractylodes, 11g of rhododendron bark, 11g of clove spices, 5g of Sichuan pepper, and 15g of tea leaves were weighed and placed in a reaction vessel. 500g of deionized water was added, and the mixture was distilled at 96°C for 2.5 hours to obtain a Chinese herbal extract.

[0071] (4) 15g of rose hydrosol and 5g of mint hydrosol were added to 45g of herbal extract to obtain a stock solution. Next, the stock solution was diluted 20 times, and 5g of dipterocarpus was added. After thorough stirring, the filtrate was obtained. 5g of chelated platinum ions and 12g of bacteriostatic agent were added, and the mixture was stirred uniformly to obtain a herbal feminine care solution.

[0072] (Comparative Example 3) The preparation method of the herbal feminine care solution included the following steps:

[0073] (1) 10 g of nano-silicon dioxide was dispersed in 70 g of 75 wt% aqueous ethanol solution, and then 17 g of 20 wt% aqueous ammonia and 6 g of (3-mercaptopropyl)trimethoxysilane were added. The mixture was stirred at 35°C for 8 hours in a N2 atmosphere. The product was then centrifuged, washed, and dried to obtain thiolated silicon dioxide.

[0074] (2) 2g of safflower, 10g of peach kernel, 10g of forsythia, 11g of chrysanthemum, 10g of shiso, 22g of bellflower, 9g of star anise, 12g of wood spices, 8g of cuckoo root, 11g of soju, 11g of white atractylodes, 11g of ginger peel, 11g of clove spices, 5g of Sichuan pepper, and 15g of tea leaves were weighed and placed in a reaction vessel. 500g of deionized water was added, and the mixture was distilled at 96°C for 2.5 hours to obtain a Chinese herbal extract.

[0075] (3) 15g of rose hydrosol and 5g of mint hydrosol were added to 45g of herbal extract to obtain a stock solution. Next, the stock solution was diluted 20 times, and 5g of dipterocarpus was added. After thorough stirring, the filtrate was obtained. 5g of chelated platinum ion and 12g of thiolated silicon dioxide were then added and stirred uniformly to obtain a herbal feminine care solution.

[0076] Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis, pathogenic bacteria commonly found in the female genital area, were selected as experimental bacterial species. Each bacterial species was prepared by activating it in bouillon medium at 37°C for 8 hours with a shaker speed of 150 rpm. The care solution products prepared in Examples 1-3 and Comparative Examples 1-3, which had been sterilized at 121°C for 20 minutes, were then added to sterile bouillon medium at a concentration of 0.05% (w / v). Next, under sterile conditions, 1 mL of the activated bacterial solution (bacterial concentration: 109 cfu / mL) was added to 49 mL of the medium. After incubation at 37°C with a shaker speed of 150 rpm for 6 hours, the bacteria were diluted and characterized using the plate count method in accordance with the national standard GB4789.2-2022, "National Standard for Food Safety: Microbiological Testing of Foods - Colony Count Measurement." The bactericidal rate was calculated using the following formula:

[0077] Bactericidal rate = (number of bacteria in the blank group - number of bacteria in the experimental group) / number of bacteria in the blank group

[0078] The unit of bacterial count was cfu / mL. See Table 1 for test results.

[0079] [Table 1]

[0080] The above description is merely a preferred specific embodiment of the present invention, and the scope of protection of the present invention is not limited thereto. Within the technical scope disclosed in the present invention, any equivalent replacement or modification made by a person skilled in the art based on the technical means and inventive idea of ​​the present invention shall be included in the scope of protection of the present invention.

Claims

1. In parts by weight, the composition comprises 10-15 parts rose hydrosol, 3-5 parts mint hydrosol, 30-45 parts Chinese herbal medicine extract, 3-5 parts dipterocarpus, 1-5 parts chelated platinum ions, and 6-12 parts bacteriostatic agent; The method for preparing the bacteriostatic agent comprises: (1) dispersing nano silicon dioxide in an ethanol aqueous solution, adding ammonia water and (3-mercaptopropyl)trimethoxysilane, stirring to react, and then centrifuging the product, washing and drying to obtain thiolated silicon dioxide; (2) adding dodecafluoroheptyl methacrylate and vinyl guanamine to N,N-dimethylformamide, stirring uniformly to obtain a mixed solution, dispersing thiolated silicon dioxide in the mixed solution and carrying out ultrasonic dispersion, adding a photoinitiator, and then irradiating with ultraviolet light to cause a reaction, centrifuging the product, washing with isopropanol, and drying to obtain a bacteriostatic agent; 1. A formulation for a herbal feminine care solution comprising:

2. The formula of claim 1, wherein in step (1), the concentration of the ethanol solution is 50-75 wt %, and the concentration of the ammonia solution is 15-25 wt %.

3. The formulation of claim 1, characterized in that in step (1), the weight ratio of nano-silicon dioxide, aqueous ethanol solution, aqueous ammonia, and (3-mercaptopropyl)trimethoxysilane is 10:50-70:8-17:3-6.

4. In step (1), the reaction conditions are ２ 2. The formulation of claim 1, wherein the reaction is carried out in an atmosphere at 20-35° C. for 5-8 hours.

5. The formulation of claim 1, wherein in step (2), the weight ratio of dodecafluoroheptyl methacrylate, vinyl guanamine, N,N-dimethylformamide, and thiolated silicon dioxide is 2-5:4-7:30-50:

10.

6. 2. The formula of claim 1, wherein in step (2), the photoinitiator is one or more of benzoin dimethyl ether, benzoin ethyl ether, and benzoin butyl ether.

7. In step (2), the ultrasonic dispersion time is 5 to 15 min, the dominant wavelength of the ultraviolet light is 360 to 365 nm, and the ultraviolet light intensity is 50 to 100 mW / cm ２ The formulation of the herbal feminine care solution according to claim 1, characterized in that the irradiation time is 30-60 minutes and the reaction temperature is 30-40°C.

8. 2. The formulation of claim 1, wherein the method for preparing the herbal extract comprises weighing 1-2 parts of safflower, 8-12 parts of peach kernel, 8-12 parts of forsythia, 8-13 parts of chrysanthemum, 7-13 parts of perilla, 18-25 parts of platycodon, 8-11 parts of star anise, 9-14 parts of sycamore, 7-12 parts of cuckoo root, 10-12 parts of atractylodes, 10-12 parts of white atractylodes, 9-13 parts of green peel, 10-12 parts of clove, 4-6 parts of Sichuan pepper, and 13-16 parts of tea leaves into a reaction vessel, adding 500 parts of deionized water, and distilling and extracting at 94-97°C for 1.5-3 hours to obtain the herbal extract.

9. 9. A method for preparing a formula of a herbal feminine care solution according to any one of claims 1 to 8, comprising: The method for preparing the herbal feminine care solution comprises the steps of adding rose hydrosol and mint hydrosol to a Chinese herbal medicine extract to obtain a stock solution, diluting the stock solution, adding dipterocarpus after diluting, thoroughly stirring, and filtering to obtain a filtrate, adding chelated platinum ions and a bacteriostatic agent, and stirring uniformly to obtain a Chinese herbal medicine-based feminine care solution.

10. The preparation method according to claim 9, characterized in that the dilution ratio of the original solution is 10 to 20 times.

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