Drug delivery device with adhesive film

Abstract

Provided herein is a drug delivery device comprising: a barrel defining an interior configured to receive a composition, the barrel including a distal tip defining a channel for providing a passageway for transporting the composition; a cylindrical adapter attached to the distal tip, the adapter including an internal thread defining at least a portion of an inner surface and an outer surface including at least one flat surface, the adapter being rotatable relative to the barrel; and a film applied to at least a portion of the barrel and at least a portion of the adapter, thereby preventing relative rotation between the adapter and the barrel.

Description

[Technical Field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to European Patent Application No. 22306728.1, filed November 23, 2022, entitled "Drug Delivery Device with Adapter," the entire disclosure of which is incorporated herein by reference in its entirety.

[0002] The present invention is directed to a drug delivery device having an adapter element mounted thereon and a film that engages the adapter to prevent rotation of the adapter relative to the remainder of the drug delivery device. [Background technology]

[0003] 2. Description of Related Art It may be desirable to prevent the luer lock adapter from rotating relative to the syringe when connected to the syringe. This can be accomplished, for example, by heat-shrinking a label or other film onto both the adapter and the syringe, as described in U.S. Pat. No. 10,661,018, the disclosure of which is incorporated herein by reference in its entirety. However, such a solution may require a heat tunnel device, which can increase capital costs and occupy space on the manufacturing floor.

[0004] Furthermore, applying such a label or film to pre-filled syringe after filling the device may be undesirable, because heat-sensitive composition should not be exposed to unnecessary heated conditions.Therefore, there is a need in the art for a film or label that is applied to adapter and syringe, which eliminates or reduces the need for heat shrinking to prevent relative rotation of adapter.In addition, regardless of application method, there is a need to provide a more secure and non-rotating connection between adapter and syringe. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] U.S. Patent No. 10,661,018 Summary of the Invention [Means for solving the problem]

[0006] Provided herein is a drug delivery device comprising: a barrel defining an interior configured to receive a composition, the barrel including a distal tip defining a channel for providing a passageway for transporting the composition; a cylindrical adapter attached to the distal tip, the adapter including an internal thread defining at least a portion of an inner surface and an outer surface including at least one flat surface, the adapter being rotatable relative to the barrel; and a film applied to at least a portion of the barrel and at least a portion of the adapter, thereby preventing relative rotation between the adapter and the barrel.

[0007] Also provided herein is a drug delivery device comprising: a barrel defining an interior configured to receive a composition, the barrel including a distal tip defining a channel for providing a passageway for transporting the composition; a cylindrical adapter attached to the distal tip, the adapter including an internal thread defining at least a portion of an inner surface and a smooth outer surface, the adapter being rotatable relative to the barrel; and a film applied to at least a portion of the barrel and at least a portion of the adapter, thereby preventing relative rotation between the adapter and the barrel.

[0008] Also provided herein is a drug delivery device including: a barrel defining an interior configured to receive a composition, the barrel including a distal tip defining a channel for providing a passageway for transporting the composition; a cylindrical adapter including an inner surface and an opposing outer surface, the adapter attached to the distal tip including an internal thread defining at least a portion of the inner surface and rotatable relative to the barrel; a film applied to at least a portion of the barrel and at least a portion of the adapter, thereby preventing relative rotation between the adapter and the barrel; and an identification tag positioned under the film together with the adapter, the identification tag configured to wirelessly communicate with a corresponding reading device.

[0009] Also provided herein is a drug delivery system, the drug delivery system including a drug delivery device as described herein and a connector including an outer surface including a thread, the connector engaging with the drug delivery device by the threads of the connector engaging with the internal threads of the adapter.

[0010] Also provided herein is a method for manufacturing the drug delivery device described herein, comprising the steps of attaching an adapter to the distal tip of the barrel and applying a film to at least a portion of the barrel and the adapter.

[0011] Also provided herein is a method of delivering a composition using a drug delivery device described herein, comprising the steps of connecting the drug delivery device to a connector including an outer surface including threads, wherein the connector engages with the drug delivery device by the threads of the connector engaging with the internal threads of the adapter, and allowing the composition inside the barrel to flow through the connector.

[0012] Other non-limiting embodiments of the present invention are described in the following numbered clauses.

[0013] Clause 1: A drug delivery device comprising: a barrel defining an interior configured to receive a composition, the barrel including a distal tip defining a channel for providing a passageway for transporting the composition; a cylindrical adapter attached to the distal tip, the adapter including an internal thread defining at least a portion of an inner surface and an outer surface including at least one flat surface, the adapter being rotatable relative to the barrel; and a film applied to at least a portion of the barrel and at least a portion of the adapter, thereby preventing relative rotation between the adapter and the barrel.

[0014] Clause 2: The drug delivery device of clause 1, which is sterilized prior to applying the film to at least a portion of the barrel and adapter.

[0015] Clause 3: A drug delivery device described in clause 1 or 2, wherein the film comprises an inner surface and an opposite outer surface, and at least a portion of the inner surface comprises an adhesive so that when the film is applied to at least a portion of the barrel and adapter, the inner surface of the film is adhered to the surface of the barrel and the surface of the adapter.

[0016] Clause 4: A drug delivery device described in any one of clauses 1 to 3, further comprising a plug removably connected to the adapter.

[0017] Clause 5: A drug delivery device described in any one of clauses 1 to 4, wherein the diameter of the barrel is substantially the same as the diameter of the adapter.

[0018] Clause 6: A drug delivery device described in any one of clauses 1 to 5, wherein the barrel comprises glass.

[0019] Clause 7: A drug delivery device described in any one of clauses 1 to 6, wherein the outer surface of the adapter is smooth.

[0020] Clause 8: A drug delivery device described in any one of clauses 1 to 7, further comprising an identification tag positioned under the film together with the adapter, the identification tag configured to communicate wirelessly with a corresponding reading device.

[0021] Clause 9: A drug delivery device as described in clause 8, wherein the adapter is overmolded with an identification tag.

[0022] Clause 10: A drug delivery device comprising: a barrel defining an interior configured to receive a composition, the barrel including a distal tip defining a channel for providing a passageway for transporting the composition; a cylindrical adapter attached to the distal tip, the adapter including an internal thread defining at least a portion of an inner surface and a smooth outer surface, the adapter being rotatable relative to the barrel; and a film applied to at least a portion of the barrel and at least a portion of the adapter, thereby preventing relative rotation between the adapter and the barrel.

[0023] Clause 11: The drug delivery device of clause 10, which is sterilized prior to applying the film to at least a portion of the barrel and adapter.

[0024] Clause 12: A drug delivery device as described in clause 10 or 11, wherein the film comprises an inner surface and an opposite outer surface, and at least a portion of the inner surface comprises an adhesive so that when the film is applied to at least a portion of the barrel and adapter, the inner surface of the film is adhered to the surface of the barrel and the surface of the adapter.

[0025] Clause 13: A drug delivery device described in any one of clauses 10 to 12, further comprising a plug removably connected to the adapter.

[0026] Clause 14: A drug delivery device described in any one of clauses 10 to 13, wherein the diameter of the barrel is substantially the same as the diameter of the adapter.

[0027] Clause 15: A drug delivery device according to any one of clauses 10 to 14, wherein the barrel comprises glass.

[0028] Clause 16: A drug delivery device described in any one of clauses 10 to 15, wherein the outer surface of the adapter comprises a pair of flat surfaces diametrically opposite each other.

[0029] Clause 17: A drug delivery device described in any one of clauses 10 to 16, further comprising an identification tag positioned under the film together with the adapter, the identification tag configured to communicate wirelessly with a corresponding reading device.

[0030] Clause 18: A drug delivery device as described in clause 17, wherein the adapter is over-molded with an identification tag.

[0031] Clause 19: A drug delivery device comprising: a barrel defining an interior configured to receive a composition, the barrel including a distal tip defining a channel for providing a passageway for transporting the composition; a cylindrical adapter including an inner surface and an opposite outer surface, the adapter attached to the distal tip including an internal thread defining at least a portion of the inner surface and rotatable relative to the barrel; a film applied to at least a portion of the barrel and at least a portion of the adapter, thereby preventing relative rotation between the adapter and the barrel; and an identification tag positioned under the film together with the adapter, the identification tag configured to wirelessly communicate with a corresponding reading device.

[0032] Clause 20: A drug delivery device according to clause 19, which is sterilised prior to applying the film to at least a portion of the barrel and adapter.

[0033] Clause 21: A drug delivery device as described in Clause 19 or 20, wherein the film comprises an inner surface and an opposite outer surface, and at least a portion of the inner surface comprises an adhesive so that when the film is applied to at least a portion of the barrel and adapter, the inner surface of the film is adhered to the surface of the barrel and the surface of the adapter.

[0034] Clause 22: A drug delivery device described in any one of clauses 19 to 21, further comprising a plug removably connected to the adapter.

[0035] Clause 23: A drug delivery device described in any one of clauses 19 to 22, wherein the diameter of the barrel is substantially the same as the diameter of the adapter.

[0036] Clause 24: A drug delivery device described in any one of clauses 19 to 23, wherein the barrel comprises glass.

[0037] Clause 25: A drug delivery device described in any one of clauses 19 to 24, wherein the outer surface of the adapter comprises a pair of flat surfaces diametrically opposite each other.

[0038] Clause 26: A drug delivery device described in any one of clauses 19 to 25, wherein the outer surface of the adapter is smooth.

[0039] Clause 27: A drug delivery device described in any one of clauses 19 to 26, wherein the adapter is overmolded with an identification tag.

[0040] Clause 28: A drug delivery system comprising a drug delivery device according to any one of clauses 1 to 27 and a connector having an outer surface including a thread, wherein the connector engages with the drug delivery device by means of the threads of the connector engaging with the internal threads of the adapter.

[0041] Clause 29: The drug delivery system of clause 28, wherein the connector comprises an intravenous tubing connector.

[0042] Clause 30: A method for manufacturing a drug delivery device described in any one of clauses 1 to 27, comprising the steps of attaching an adapter to the distal tip of the barrel and applying a film to at least a portion of the barrel and the adapter.

[0043] Clause 31: The method of clause 30, further comprising sterilizing the drug delivery device before applying the film to at least a portion of the barrel and adapter.

[0044] Clause 32: A method for delivering a composition using a drug delivery device described in any one of clauses 1 to 27, comprising the steps of connecting the drug delivery device to a connector having an outer surface including a thread, wherein the connector engages with the drug delivery device by the threads of the connector engaging with the internal threads of the adapter, and allowing the composition inside the barrel to flow through the connector. [Brief explanation of the drawings]

[0045] [Figure 1] 1 is a cross-sectional view of a drug delivery device according to a non-limiting embodiment described herein. [Figure 2] 1 is a cross-sectional view of a drug delivery device engaging a plug according to non-limiting embodiments described herein. [Figure 3] 1 is a cross-sectional view of a drug delivery device having an identification tag and engaging a plug according to non-limiting embodiments described herein. [Figure 4] FIG. 10 is a perspective view of a drug delivery device engaging a plug before the drug delivery device is covered with a film according to non-limiting embodiments described herein. [Figure 5] FIG. 1 is a perspective view of a drug delivery device having an identification tag and engaging a plug before the drug delivery device is covered with a film according to non-limiting embodiments described herein. [Figure 6] FIG. 10 is a perspective view of a drug delivery device engaged with a plug and covered with a film, with a cutout shown in the area of ​​the adapter, according to non-limiting embodiments described herein. [Figure 7] FIG. 10 is a side view of a drug delivery device in which the film also covers a portion of the plug attached to the adapter according to non-limiting embodiments described herein. [Figure 8] FIG. 1 is a perspective view of a film for a drug delivery device according to non-limiting embodiments described herein. [Figure 9] 9 is a perspective view of the film of FIG. 8 showing the film rolled as if applied to a drug delivery device according to non-limiting embodiments described herein. [Figure 10] 10A-10C are cross-sectional views of a drug delivery device engaging a connector according to non-limiting embodiments described herein. DETAILED DESCRIPTION OF THE INVENTION

[0046] [Detailed Description of the Invention] The following description is provided to enable any person skilled in the art to make and use the described embodiments intended to practice the invention. However, various modifications, equivalents, variations, and alternatives will be readily apparent to those skilled in the art. Any and all such modifications, variations, equivalents, and alternatives are intended to be within the spirit and scope of the present invention.

[0047] Hereinafter, for purposes of explanation, the terms "upper," "lower," "right," "left," "vertical," "horizontal," "top," "bottom," "transverse," "longitudinal," and their derivatives will refer to the present invention as oriented in the drawings. However, it will be understood that the present invention may assume various alternative modifications unless expressly specified to the contrary. It should also be understood that the specific devices illustrated in the accompanying drawings and described in the following specification are merely exemplary embodiments of the present invention. Hence, specific dimensions and other physical characteristics related to the embodiments disclosed herein are not to be considered limiting.

[0048] It should be understood that any numerical range recited herein is intended to include all subranges subsumed therein. For example, a range of "1 to 10" is intended to include all subranges between (and including) the stated minimum of 1 and the stated maximum of 10, i.e., ranges having a minimum of 1 or more and a maximum of 10 or less.

[0049] 1-3, a drug delivery device 1 of assembly 101 is shown according to some non-limiting embodiments. Drug delivery device 1 can include a barrel 2 defining an interior 22 configured to hold a composition. The composition can be a pharmaceutical composition. Drug delivery device 1 has a longitudinal axis A. Drug delivery device 1 can be a manual syringe or, optionally, a pre-filled syringe.

[0050] The barrel 2 may have a distal tip 3. The barrel 2 and distal tip 3 may be formed of one single material (e.g., plastic, glass, or other known material). The barrel 2 and distal tip 3 may preferably be made of glass. The barrel 2 may be sealed at its proximal end by a piston (not shown). The distal tip 3 may define a channel 4 aligned with the longitudinal axis A, providing a passage for the transfer of a composition either from the barrel 2 to a connector 11 (not shown), such as an IV connector or syringe needle, or from a vial to the barrel 2. The outer surface of the distal tip 3 may have a slightly tapered shape.

[0051] 1-5, a cylindrical adapter 5 defining a ring 6 is also shown. The ring 6 may be provided at its proximal region with an internal protrusion in the form of a discontinuous annular bulge 7 extending radially inward. The annular bulge 7 may be made of a material sufficiently flexible to allow the annular bulge 7 to expand slightly radially outward under pressure exerted on the inner wall of the annular bulge 7. Alternatively, the annular bulge 7 may be replaced by a continuous annular bulge capable of expanding radially outward. The inner wall of the ring 6 may include an internal thread 8 that defines at least a portion of the inner surface 23 of the adapter 5. The internal thread 8 may be spaced distally from the annular bulge 7. The adapter 5 may be made of a flexible material, such as plastic.

[0052] The adapter 5 may be cylindrical, as shown in FIGS. 1-5. The cylindrical shape of the adapter 5 may have an outer surface 25 including at least one flat surface 28. The outer surface 25 may include a single flat surface. The outer surface 25 may include a pair of flat surfaces 28. The outer surface 25 may include more than two flat surfaces 28, such as three or four flat surfaces 28. In some non-limiting examples, a pair of flat surfaces 28 diametrically opposed to each other (not shown) may be included. "Diametrically opposed" means that the first flat surface is positioned approximately 40-60% of the circumference of the cylinder relative to the second flat surface. The first flat surface may be directly opposite the second flat surface (approximately 50% of the circumference of the cylinder). The flat surfaces 28 may be parallel to each other. At least one flat surface 28 may extend along the length of the adapter 5.

[0053] The cylindrical adapter 5 may have a smooth outer surface 25. As used herein, "smooth" is meant to mean that the outer surface 25 of the adapter 5 is free of any noticeable protrusions or irregularities. A noticeable protrusion or irregularity is one in which the diameter of one point on the cylindrical adapter 5 is more than 5% larger than the diameter of a second point on the cylindrical adapter 5. In some non-limiting embodiments (not shown), the cylindrical adapter 5 may be completely cylindrical and have no protrusions or irregularities. The smooth outer surface 25 of the adapter 5 allows the adhesive film 9 to be more firmly adhered thereto.

[0054] The adapter 5 may be attached to the distal tip 3 by a friction fit, adhesive, a threaded connection, or other connection known to those skilled in the art. The adapter 5 may be rotatable relative to the barrel 2 prior to application of the film 9 described below. The adapter 5 may abut against a shoulder of the barrel 2, such as being in physical contact with the barrel 2. Alternatively, a small gap may exist between the adapter 5 and the shoulder of the barrel 2. A lack of or a small gap between the adapter 5 and the shoulder of the barrel 2 may create a more uniform cylinder suitable for secure adhesion of the adhesive film 9.

[0055] 2, the diameter D1 of the barrel 2 can be substantially the same diameter as the diameter D2 of the adapter 5, such as the distal region 2a of the barrel 2 having substantially the same diameter as the proximal region 5a of the adapter 5. Substantially the same diameter means that the diameters D1, D2 are within 5%, for example, within 1%, or identical to each other. Having the barrel 2 and the adapter 5 with substantially the same diameter may make the drug delivery device 1 compatible for applying a film 9 extending from the barrel 2 to the adapter 5, as described below.

[0056] Referring again to FIGS. 1-3 , a non-limiting embodiment of a drug delivery device 1 having an adapter 5 attached to its distal tip 3 is shown. The drug delivery device 1 may be sterilized before applying the film 9. The drug delivery device 1 may be sterilized using steam sterilization or any other process known to those skilled in the art. The film 9 may then be applied to the sterilized drug delivery device 1, such as to at least a portion of the barrel 2 and at least a portion of the adapter 5. Application of the film 9 to both the barrel 2 and the adapter 5 can prevent rotation between the adapter 5 and the barrel 2, such as during use of the drug delivery device 1. The film 9 may be applied to the distal region 2a of the barrel 2 and the proximal region 5a of the adapter 5, as shown in FIGS. 1-3 .

[0057] The film 9 may include a label containing one or more indicia. The film 9 may be transparent, translucent, or opaque and / or may include writing such as, for example, graduations, brand name, lot number, expiration date, drug code, or other useful information.

[0058] The film 9 may be made of a thermoplastic material. In some non-limiting embodiments, the film 9 is made of paper, polyvinyl chloride, polyester, polyethylene, polyamide, polypropylene, vinyl, or some combination thereof. In some non-limiting embodiments, the film 9 is made of a polyvinyl chloride-containing material.

[0059] In some non-limiting embodiments, the film 9 may be an adhesive film. As shown in Figures 8 and 9, the film 9 may have an inner surface 18 and an outer surface 30. The inner surface 18 of the film 9 may have an adhesive material 32 over at least a portion thereof, as shown in Figure 8. Figure 9 shows the film 9 rolled up as if applied to a drug delivery device 1 (not shown). It will be understood that the adhesive material 32 on the inner surface 18 may adhere the film 9 to the barrel 2 and adapter 5 when the film 9 is rolled up and applied to the drug delivery device 1. The adhesive material 32 may include an adhesive or any other type of adhesive suitable for securely adhering the film 9 to the barrel 2 and adapter 5, thereby preventing relative rotation between the adapter 5 and the barrel 2.

[0060] 1-3 , the presence of the film 9 can limit and / or prevent the adapter 5 from rotating relative to the barrel 2 about the longitudinal axis A. The film 9 can also prevent the adapter 5 from translating longitudinally relative to the barrel 2. As a result, the user can easily and safely attach the drug delivery device 1 including the adapter 5 to another device (e.g., connector 11).

[0061] 2-7, the drug delivery device 1 may include a plug 10 attached to an adapter 5. To protect the adapter 5 and / or maintain sterility of the adapter 5, the plug 10 may be removably attached to the adapter 5 and may limit access to the adapter 5 prior to use. The plug 10 includes threads 42 configured to engage the internal threads 8 of the adapter 5, allowing the plug 10 and adapter 5 to engage in a secure threaded connection.

[0062] 7 , a non-limiting embodiment is shown in which the film 9 is longer and covers at least a portion of the plug 10. Thus, the film 9 may cover, for example, continuously, a portion of the barrel 2, the adapter 5 (not shown), and a portion of the plug 10. Also, in a non-limiting embodiment in which the film 9 covers a portion of the plug 10 attached to the adapter 5, the plug 10 may be attached to the adapter 5 before applying the film 9, and the length of the film 9 may be selected to cover at least a portion of the adapter 5 and the plug 10.

[0063] 3 and 5 , the drug delivery device 1 may further include an identification tag 36. The identification tag 36 may be disposed under the film 9 along with the adapter 5. The identification tag 36 may be configured to wirelessly communicate with a corresponding reading device 38. The identification tag 36 may be disposed on the outer surface 25 of the adapter 5 and under the film 9. The identification tag 36 may be embedded in a wall of the adapter 5 and under the film 9. The identification tag 36 may be overmolded onto the adapter 5 and under the film 9. The identification tag 36 may be disposed under the film 9 so as not to be visible to a user during use of the drug delivery device 1.

[0064] The identification tag 36 may store data regarding the drug delivery device 1. For example, the data may include a unique identifier that allows for identification and / or traceability of a particular drug delivery device 1. The data may include other useful data, such as the type of composition contained in the drug delivery device 1, the dosage of the composition, the expiration date of the composition, the date the composition was prepared, information about the intended recipient, administration instructions, side effect information, etc. The data may include historical location data (e.g., location and date / time) of the drug delivery device 1 to track the location history of the drug delivery device 1.

[0065] The identification tag 36 may communicate wirelessly with the reading device 38. In some non-limiting examples, the identification tag 36 is a radio frequency identification (RFID) tag and the reading device 38 is an RFID reader. However, it will be understood that other wireless and / or short-range communication technologies may be used for the identification tag 36 and the reading device 38. The reading device 38 may communicate with the identification tag 36 to read the data stored in the identification tag 36. The reading device 38 may display at least a portion of the read data on a user interface (not shown) so that a user can view the data stored in the identification tag 36. The reading device 38 communicating with the identification tag 36 may cause updated location data associated with the drug delivery device 1 to be stored in a central database, such as a central database tracking the locations of multiple drug delivery devices.

[0066] Referring to FIG. 10 , a drug delivery system 201 according to some non-limiting embodiments is shown. The drug delivery system 201 may include a drug delivery device 1 as described herein. The drug delivery system 201 may also include a connector 11. The connector 11 may be any other device having a connection compatible with the adapter 5. For example, the connector 11 may include a connector to an IV, a syringe needle, or the like. The connector 11 may have a Luer connection. The connector 11 may include an external thread 12 on an outer surface 40 of the connector 11. The external thread 12 may be configured to mate with the internal thread 8 of the adapter 5 to engage the connector 11 and the adapter 5 in a secure threaded connection. The drug delivery device 1 may engage the connector 11 after applying a film 9 to the barrel 2 and the adapter 5.

[0067] Referring back to Figures 2-7 and 10, non-limiting embodiments of a drug delivery device 1 with a closed adapter 5 are shown. In Figures 2-7, the adapter 5 is closed by engagement with a plug 10, and in Figure 10, the adapter 5 is closed by engagement with a connector 11. To begin the process of connecting the adapter 5, closed by the plug 10, to another device, such as a connector 11, a user may first grasp the drug delivery device 1 with one hand through the film 9 and remove the plug 10. Next, the user may attach the connector 11 to the internal threads 8 of the adapter 5 and engage the connector 11 with the adapter 5 without rotation or longitudinal translation of the adapter 5 relative to the barrel 2 due to the presence of the film 9, as shown in Figure 10. When the external threads 12 of the connector 11 are securely received by the internal threads 8 of the adapter 5, the drug delivery device 1 and connector 11 may be securely connected to prevent leakage of the composition when flowing from or to the barrel 2.

[0068] As described herein, drug delivery device 1 can be manufactured by attaching adapter 5 to the distal tip 3 of barrel 2. Barrel 2 can be pre-filled with a pharmaceutical composition. Film 9 can be applied to at least a portion of barrel 2 and at least a portion of adapter 5, thereby preventing relative rotation between adapter 5 and barrel 2. Film 9 can be fixedly adhered to barrel 2 and adapter 5 by adhesive material 32 on an inner surface 18 of film 9 that contacts barrel 2 and adapter 5.

[0069] As described herein, drug delivery device 1 can deliver a composition contained in barrel 2 to a patient, another device, or the like. Drug delivery device 1 can deliver the composition by connecting drug delivery device 1 to connector 11 including an outer surface 40 including external threads 12, where connector 11 is engaged with drug delivery device 1 by external threads 12 of connector 11 engaging internal threads 8 of adapter 5. The method can further include causing the composition in interior 22 of barrel 2 to flow through connector 11. For example, drug delivery device 1 can include a plunger (not shown) including a piston at its proximal end, forcing the composition from barrel 2, through channel 4, through adapter 5, and through connector 11.

[0070] While the present disclosure has been described in detail for purposes of illustration, based on what are presently considered to be the most practical and preferred embodiments, it should be understood that such detail is for that purpose only, and that the present disclosure is not limited to the disclosed embodiments, but on the contrary, is intended to cover modifications and equivalent arrangements within the spirit and scope of the appended claims. For example, it should be understood that the present disclosure contemplates that, to the extent possible, one or more features of any embodiment may be combined with one or more features of any other embodiment.

Claims

1. 1. A drug delivery device comprising: a barrel defining an interior configured to receive a composition, the barrel including a distal tip defining a channel providing a passageway for transporting said composition; a cylindrical adapter attached to the distal tip, the adapter including internal threads defining at least a portion of an inner surface and an outer surface including at least one flat surface, the adapter being rotatable relative to the barrel; a non-heat shrinkable film comprising an adhesive, the film being applied to at least a portion of the barrel and at least a portion of the adapter, thereby preventing relative rotation between the adapter and the barrel; 1. A drug delivery device comprising:

2. 10. The drug delivery device of claim 1, which is sterilized prior to application of the film to at least a portion of the barrel and the adapter.

3. 3. The drug delivery device of claim 1, wherein the film comprises an inner surface and an opposite outer surface, and at least a portion of the inner surface comprises the adhesive such that when the film is applied to at least a portion of the barrel and the adapter, the inner surface of the film is adhered to the surface of the barrel and the surface of the adapter.

4. The drug delivery device of any one of claims 1 to 3, further comprising a plug removably connected to the adapter.

5. The drug delivery device according to any one of claims 1 to 4, wherein the diameter of the barrel is substantially the same as the diameter of the adapter.

6. The drug delivery device of any one of claims 1 to 5, wherein the barrel comprises glass.

7. The drug delivery device according to any one of claims 1 to 6, wherein the outer surface of the adapter is smooth.

8. The drug delivery device of any one of claims 1 to 7, further comprising an identification tag positioned under the film together with the adapter, the identification tag configured to communicate wirelessly with a corresponding reading device.

9. The drug delivery device of claim 8 , wherein the adapter is overmolded with the identification tag.

10. 1. A drug delivery system comprising: A drug delivery device according to any one of claims 1 to 9; a connector including an outer surface including a thread; wherein the connector engages the drug delivery device by threads of the connector engaging internal threads of the adapter.

11. The drug delivery device of claim 10 , wherein the connector comprises an intravenous tubing connector.

12. attaching the adapter to the distal tip of the barrel; applying the film to at least a portion of the barrel and the adapter; A method for manufacturing the drug delivery device of any one of claims 1 to 9, comprising:

13. 13. The method of claim 12, further comprising sterilizing the drug delivery device before applying the film to at least a portion of the barrel and the adapter.

14. A method of delivering a composition using the drug delivery device of any one of claims 1 to 9, comprising: connecting the drug delivery device to a connector including an outer surface including threads, the connector engaging the drug delivery device with the threads of the connector engaging the internal threads of the adapter; allowing the composition to flow through the connector within the barrel; A method comprising:

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