Artificial capsule devices, systems, and methods

Abstract

Embodiments herein generally relate to systems, methods, and devices including an artificial capsule device configured to be inserted into the lens capsule of an eye, the artificial capsule device comprising a housing structure including an anterior portion and a posterior portion, an internal cavity, a groove formed along the periphery of the internal cavity, and a drug delivery device having a ring or arc configuration, the drug delivery device being held in place within the groove within the internal cavity of the housing structure.

Description

[Technical Field]

[0001] (Incorporation by reference of priority application) This application claims the benefit under 35 U.S.C. § 119(c) of U.S. Provisional Patent Application No. 63 / 428,102, filed November 27, 2022, which is incorporated herein by reference in its entirety under 37 C.F.R. § 1.57. [Background technology]

[0002] FIELD OF THE DISCLOSURE Embodiments of the present disclosure relate generally to ophthalmic prosthetics, and more particularly to devices, systems, and methods for prosthetics for insertion into the eye.

[0003] (explanation) Cataract surgery is one of the most successful and frequently performed surgical procedures in the United States. Each year, millions of people achieve dramatic improvements in visual function thanks to this procedure. With an increasing percentage of the U.S. population entering retirement, the demand for cataract surgery is expected to nearly double over the next 20 years, from 3.3 million to more than 6 million annually. To meet the growing demand, more ophthalmologists are likely to be trained and certified to perform cataract surgery, and each trained and certified ophthalmologist is likely to perform more cataract surgeries each year.

[0004] (overview) For purposes of this Summary, certain aspects, advantages, and novel features of the invention are described herein. It is to be understood that not all such advantages may necessarily be achieved in accordance with any particular embodiment of the invention. Thus, for example, one skilled in the art will recognize that the invention may be embodied or practiced in a way that achieves one advantage or group of advantages as taught herein, without necessarily achieving other advantages that may be taught or suggested herein.

[0005] Some embodiments herein relate to a prosthetic capsular device configured to be inserted into a natural capsular bag of an eye, the prosthetic capsular device including a housing structure and a drug delivery device, the housing structure includes a front portion, a rear portion, an internal cavity, and a groove; The front portion is A forward circular opening; a forward rim surrounding the forward circular opening and defining a perimeter of the forward circular opening; a forward sidewall connected to the forward rim and extending laterally outward and rearward from the forward rim to a center plane of the housing structure; The rear portion is A rear circular opening; a rear rim surrounding the rear circular opening and defining a perimeter of the rear circular opening; a rear sidewall connected to the rear rim and extending laterally outward and forward from the rear rim to a longitudinal center plane of the housing structure; the internal cavity is defined between the front circular opening and the rear circular opening and is configured to accommodate the medication delivery device; the groove is formed by one or more ribs formed along a periphery of the internal cavity at the longitudinal center plane of the housing structure, each rib of the one or more ribs including upper and lower surfaces formed with a rib angle, and the groove is configured to hold the medication delivery device in place within the internal cavity of the housing structure; The drug delivery device has a ring or arc configuration, and the drug delivery device is held in place within the groove formed by the one or more ribs within the interior cavity of the housing structure.

[0006] In some embodiments, the drug delivery device comprises a circular, square, rectangular, oval, triangular, rounded triangular, pentagonal, trapezoidal, elliptical, semicircular, hexagonal, octagonal, ring, diamond, or star shape when viewed in profile. In some embodiments, the drug delivery device comprises a length and a width, and the ratio of the length to the width is about 2:1 to about 200:1. In some embodiments, the length is between 1 mm and 50 mm.

[0007] In some embodiments, the drug delivery device contacts an interior surface or inner sidewall of the housing structure.In some embodiments, the drug delivery device is configured to bend or curve from a straight configuration into a ring or arc configuration.

[0008] In some embodiments, the drug delivery device includes an outer diameter of about 3 mm to about 12 mm. In some embodiments, the length of the drug delivery device is substantially equal to the perimeter of the internal cavity of the housing structure. In some embodiments, the length of the drug delivery device is longer than the perimeter of the internal cavity of the housing structure such that at least a portion of the drug delivery device overlaps when the drug delivery device is retained in the internal cavity.

[0009] In some embodiments, the length of the drug supply device is shorter than the outer periphery of the internal cavity of the housing structure. In some embodiments, the artificial capsule device further includes a second drug supply device having an arc configuration, the second drug supply device being held in place within a groove formed by one or more ribs in the internal cavity of the housing structure. In some embodiments, the second drug supply device has a second length, and the sum of the length of the drug supply device and the second length of the second drug supply device is approximately equal to the outer periphery of the internal cavity of the housing structure. In some embodiments, the drug supply device and the second drug supply device collectively substantially form a ring shape within the groove of the housing structure.

[0010] In some embodiments, the drug delivery device comprises a bioerodible material. In some embodiments, the bioerodible material comprises collagen, alginate, poly(lactic-co-glycolic acid) (PLGA), polyanhydride, polycaprolactone, poly(trimethylene carbonate), or polyphosphazene. In some embodiments, the bioerodible material is impregnated or infused with one or more drugs. In some embodiments, the one or more drugs comprise an anti-inflammatory agent (NSAIDs, steroids), an anti-fibrotic agent (mitomycin), an immunomodulatory agent (cyclosporine, tacrolimus, methotrexate), an antiviral agent (ganciclovir, valcyclovir, acyclovir), an antibiotic, an antifungal agent (voriconazole, natamycin, amphotericin B), or an anti-VEGF agent (avastin, lucentis, eylea).

[0011] In some embodiments, the drug delivery device comprises silicone, vulcanized silicone, and / or a silicone polymer. In some embodiments, the drug delivery device includes one or more holes, eyelets, slits, and / or openings. In some embodiments, the one or more holes, eyelets, slits, and / or openings are configured to allow the drug delivery device to be positioned within the interior cavity of the housing structure by an injector. [Brief explanation of the drawings]

[0012] The drawings are provided to illustrate exemplary embodiments and are not intended to limit the scope of the present disclosure. A better understanding of the systems and methods described herein will be appreciated by reference to the following description in conjunction with the accompanying drawings, in which:

[0013] FIG. 1 shows an exemplary artificial capsule device according to some embodiments of the present disclosure.

[0014] Figure 2 is a front perspective view of the exemplary artificial capsule device of Figure 1.

[0015] Figure 3 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0016] Figure 4 is a front perspective view of the exemplary artificial capsule device of Figure 3.

[0017] Figure 5 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0018] Figure 6 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0019] Figure 7 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0020] Figure 8 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0021] Figure 9 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0022] Figure 10 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0023] Figure 11 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0024] Figure 12 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0025] Figure 13 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0026] Figure 14 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0027] Figure 15 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0028] Figure 16 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0029] Figure 17 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0030] Figure 18 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0031] Figure 19 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0032] Figure 20 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0033] Figure 21 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0034] Figure 22 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0035] Figure 23 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0036] Figure 24 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0037] Figure 25 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0038] Figure 26 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0039] Figure 27 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0040] Figure 28 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0041] Figure 29 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0042] Figure 30 shows another exemplary artificial capsule device according to some embodiments of the present specification.

[0043] Figure 31 is an illustrative diagram of the interaction between an artificial capsule device and the iris of the eye.

[0044] Figure 32 is an illustrative diagram of an artificial capsule device in the eye.

[0045] Figure 33 shows an example image of an artificial capsule device in the eye according to some embodiments of the present disclosure.

[0046] FIG. 34 illustrates another exemplary prosthetic device according to some embodiments herein.

[0047] FIG. 35 illustrates another exemplary prosthetic device according to some embodiments herein.

[0048] FIG. 36 illustrates another exemplary prosthetic device and an exemplary intraocular lens therein according to some embodiments herein.

[0049] FIG. 37 illustrates another exemplary prosthetic device and an exemplary intraocular lens therein according to some embodiments herein.

[0050] FIG. 38 illustrates another exemplary prosthetic device and an exemplary intraocular lens therein according to some embodiments herein.

[0051] FIG. 39 illustrates another exemplary prosthetic device and an exemplary intraocular lens therein according to some embodiments herein.

[0052] FIG. 40 illustrates an exemplary injector cartridge for use in a method of inserting a prosthetic intraocular device and / or an intraocular lens, according to some embodiments herein.

[0053] FIG. 41 illustrates another exemplary prosthetic device according to some embodiments herein.

[0054] FIG. 42A shows a schematic diagram of a kit for use in an ophthalmic surgical procedure according to some embodiments herein.

[0055] 42B-42G show schematic diagrams of drug delivery devices according to some embodiments herein.

[0056] FIG. 42H illustrates a drug delivery device within an exemplary prosthetic device according to some embodiments herein.

[0057] 43A-43B show a flow chart of a method of inserting a kit according to some embodiments herein.

[0058] 44A-44D illustrate another exemplary prosthetic device according to some embodiments herein. DETAILED DESCRIPTION OF THE INVENTION

[0059] (detail) Although certain preferred embodiments and examples are disclosed below, the inventive subject matter extends beyond the specifically disclosed embodiments to other alternative embodiments and / or uses, as well as modifications and equivalents thereof. Accordingly, the claims appended hereto are not limited to the specific embodiments described below. For example, in any method or process disclosed herein, the acts or operations of the method or process may be performed in any suitable order and are not necessarily limited to the particular order disclosed. Although various operations may be described sequentially as multiple discrete operations, in a manner that may be useful in understanding particular embodiments, the order of description should not be construed to imply that these operations are order-dependent. Furthermore, structures, systems, and / or devices described herein may be embodied as integrated or separate components. For purposes of comparing various embodiments, certain aspects and advantages of these embodiments are described. Not all such aspects or advantages are achieved by any particular embodiment. Thus, for example, various embodiments may be implemented in a manner that achieves or optimizes one advantage or advantages as taught herein without necessarily achieving other aspects or advantages as may be taught or suggested herein.

[0060] Certain exemplary embodiments will now be described to provide a general understanding of the principles of the structure, function, manufacture, and use of the devices and methods disclosed herein. One or more examples of these embodiments are illustrated in the accompanying drawings. Those skilled in the art will understand that the devices and methods specifically described herein and illustrated in the accompanying drawings are non-limiting exemplary embodiments, and that the scope of the invention is defined only by the claims. Features illustrated or described in connection with one exemplary embodiment may be combined with features of other embodiments. Such modifications and variations are intended to be within the scope of the technology.

[0061] Devices and methods useful for providing the desired refractive endpoint in cataract surgery are described in U.S. Patent Nos. 8,900,300, 9,414,907, 9,358,103, and 10,603,162, each of which is incorporated herein by reference in its entirety. All patents, patent applications, and other documents mentioned in this application are incorporated herein by reference in their entirety.

[0062] In addition to the increasing demand for cataract surgery, technological advances are also raising patient expectations. Surgeries are performed in a short time, and patients expect their vision to be restored quickly. Patients also expect their ophthalmologists to restore more youthful vision without glasses through the use of multifocal intraocular lenses, extended depth of focus lenses, accommodative lenses, other presbyopia corrective lenses, toric lenses, and monovision, to name a few. Despite accurate preoperative measurements and excellent surgical techniques, postoperative results can vary due to undesirable physiological interactions with surgical implants.

[0063] Some embodiments herein are directed to artificial capsule devices and methods that address problems associated with conventional devices. For example, the artificial capsule devices herein may be designed to eliminate, reduce, or mitigate contact between the iris pigment epithelium of the eye and the artificial capsule device. The implantation of intraocular lenses (IOLs) or conventional artificial capsule devices has become a routine procedure among many surgeons, and several studies have documented the benefits of securing IOLs and other devices within the capsular bag. However, posterior iris chafing by these devices or IOLs can lead to pigment dispersion and related inflammatory complications, particularly the well-known uveitis-glaucoma-hyphema (UGH) syndrome. For example, abrasion can cause blurred vision, eye pain, headache, pigment dispersion on the intraocular and intraocular lens surfaces, iris transillumination defects, iris changes including vacuolation / destruction / loss of the pigment layer, iris thinning, iris atrophy, etc. With increased pigment loss from the iris, the eye may experience iris transillumination defects, pigmentation of the corneal endothelium (Krukenberg spindles), and angle pigmentation along the trabecular meshwork. Without being limited to a particular theory, it is speculated that the relatively large anterior-posterior thickness and size and shape of conventional prosthetic devices, including sharp or straight edges, may have caused or contributed to this abrasion and related complications. Therefore, the prosthetic devices described herein are designed to eliminate, reduce, or mitigate posterior iris abrasion.

[0064] Another problem associated with conventional intraocular lenses and prosthetic devices implanted with intraocular lenses is lens tilt. Lens tilt occurs when the angle between the optical axis and visual axis of the intraocular lens is inconsistent, which can occur when the intraocular lens becomes misaligned within the lens capsule and / or the artificial capsule device. Lens tilt, along with intraocular lens decentration, can result in suboptimal refractive results for patients. For example, lens tilt can cause astigmatism and higher-order aberrations. Significant intraocular lens tilt or decentration can cause astigmatism that significantly impacts the quality of vision. Multifocal, toric, and toric multifocal intraocular lenses are more sensitive to slight changes in tilt than monofocal intraocular lenses, requiring particularly accurate and precise centration parameters. Therefore, the artificial capsule devices described herein can be configured to secure an intraocular lens therein such that the possibility of lens tilt and / or decentration is minimized.

[0065] The intravitreal space has been widely used for steroid injections to treat inflammatory and vascular diseases over the past 30 years, and over the past 15 years or so, it has also been widely used to treat wet age-related macular degeneration and other vascular proliferative retinal diseases with injections of anti-VEGF monoclonal antibodies, dexamethasone, and fluocinolone acetanide.

[0066] Intravitreal drug delivery advantageously places a larger potential amount of drug in close proximity to the retina. However, intravitreal drug delivery typically requires monthly or other periodic injections. Because the drugs are sometimes opaque, they can interfere with the retina's ability to receive light and / or reduce vision. Intravitreal injections can damage the natural lens capsule and lens, increase intraocular pressure, and / or cause eye tissue damage, such as retinal detachment and endophthalmitis.

[0067] The anterior segment of the eye has only recently become a focus of attention as a target for drug delivery. Recently, drugs such as dexamethasone and bimatroprost were approved by the FDA for the treatment of postoperative inflammation and glaucoma, respectively. While both of these treatments are effective, controlling drug placement is challenging. When drugs are placed in the anterior segment, migration adjacent to the corneal endothelium can cause damage. Similarly, iris atrophy has been noted in patients with prolonged contact of certain drugs with the iris. Unlike the posterior segment (vitreous cavity), controlling the placement of controlled-release drug implants plays an important role in preventing complications.

[0068] Therefore, it may be advantageous to utilize an ophthalmic device configured to continuously deliver medication to ocular tissues, thereby eliminating the need for periodic injections into the eye and avoiding the adverse effects of such injections. In some embodiments, such an ophthalmic device may include an artificial capsule device for insertion into the lens capsule, and in some embodiments, the artificial capsule device may be configured to form a space, void, or volume within the eye to receive a drug delivery device for placement within the eye. In some embodiments, an intraocular lens is inserted into the lens capsule first, followed by the artificial capsule device. In some embodiments, the artificial capsule device is positioned anterior to the intraocular lens, allowing the artificial capsule device to form an extant intraocular capsule space accessible through the pupil and capsulorhexis. The drug delivery device may be inserted into the artificial capsule device, and in some embodiments, the drug delivery device is positioned peripherally with respect to the visual pathway so as not to obstruct, interfere with, or block (essentially or substantially) the visual pathway. In some environments, the drug delivery device is configured to dissolve, partially dissolve, or otherwise change over time, thereby releasing at least a portion of the drug within the drug delivery device into the eye. In some embodiments, the artificial capsule device can receive one or more second drug delivery devices, for example, after the first drug delivery device has dissolved or after substantially all of the drug within the drug delivery device has been released into the eye, or simultaneously or subsequently with the first drug delivery device, for example, to simultaneously release multiple drugs into the eye.

[0069] In some embodiments, a drug or drug delivery device can be inserted into the device housing so that the artificial capsule is impregnated with the active agent during the molding process. In some embodiments, the artificial capsule can be coated with a drug internally, externally, or both after the molding process, allowing the drug to dissolve from the surface of the artificial capsule. In some embodiments, the artificial capsule is placed in a solution containing the active agent at some point after molding (either before or after packaging, e.g., immediately before surgery), allowing the drug to soak into the silicone pores and dissolve into the eye over time. In some embodiments, the drug delivery device is composed of a biocompatible, flexible, non-absorbable tubular material, contains an active agent therein, and has an opening or openings that allow for controlled release of the drug. In this embodiment, once the active agent has substantially dissolved, the drug-containing tube can be removed from the eye and a new device can be inserted. This process can be performed throughout the patient's lifetime for the treatment of existing disease processes, as the artificial capsule device housing is configured to allow the insertion and removal of a drug delivery device or the insertion of a new drug. In some embodiments, the housing of the artificial capsule device is configured to maintain a self-expanded state while positioned within the lens capsule, and the housing of the device includes an opening configured to remain open while positioned within the lens capsule, allowing a drug delivery device and / or drug to be inserted into the interior of the artificial capsule device housing, so that the housing of the artificial capsule device is configured for insertion of a new drug delivery device or drug for years or decades. In some embodiments, the drug delivery device may be bioerodible. In some embodiments, the drug delivery device may release one or more drugs into the lens capsule. In some embodiments, the drug delivery device may be configured to include a substantially linear, elongated configuration. In some embodiments, the substantially linear, elongated configuration allows the drug delivery device to be easily inserted into a delivery cannula, trocar, or injector for placement within the artificial capsule device.In some embodiments, the substantially linear, elongated drug delivery device is configured to bend within the artificial capsule device. In some embodiments, bending the linear, elongated drug delivery device allows the drug delivery device to be positioned in a peripheral region of the artificial capsule device to avoid obstructing or blocking the visual pathway of the eye. In some embodiments, the substantially linear, elongated drug delivery device may include end portions that are substantially curved, while a middle portion of the drug delivery device is substantially linear.

[0070] In some embodiments, the drug delivery device can be configured to include a substantially curved shape configuration. In some embodiments, the drug delivery device can be configured to include a bias such that the drug delivery device assumes the curved shape configuration. In some embodiments, a curved drug delivery device can be straightened into a straighter configuration for insertion through an insertion cannula, trocar, or injector for implantation into the artificial capsule device. In some embodiments, after the curved drug delivery device is positioned within the artificial capsule device, an inherent bias in the drug delivery device allows the drug delivery device to assume a curved shape within the artificial capsule device. In some embodiments, the bias in the curved drug delivery device allows the drug delivery device to position itself in a peripheral region of the artificial capsule device to avoid interfering with or obstructing the visual pathway of the eye. In some embodiments, the biased drug delivery device is configured to self-expand within the artificial capsule device to assume a curved shape. In some embodiments, the drug delivery device can bend and / or self-expand from a substantially straight configuration to a substantially ring configuration. In some embodiments, the drug delivery device can include a substantially cylindrical shape. In some embodiments, the drug delivery device can include a profiled shape. In some embodiments, the profile shape can be substantially circular, oval, elliptical, diamond-shaped, triangular, rectangular, pentagonal, hexagonal, octagonal, and / or any other shape. In some embodiments, the drug delivery device includes substantially smooth and / or rounded edges, and in some embodiments, the smooth and / or rounded edges prevent rubbing against the sidewalls of the artificial capsule device.In some embodiments, the artificial capsule device includes a groove within the housing of the artificial capsule device that is configured to receive and / or retain the drug delivery device when the drug delivery device is inserted into the artificial capsule device and self-expands and / or returns to the biased curved and / or ring configuration of the drug delivery device.

[0071] Additional technologies can be coupled to the artificial capsule device. In some embodiments, the artificial capsule device can be coupled to the ciliary muscle so that the ciliary muscle can expand and / or contract the artificial capsule device. In some embodiments, one or more lenses are coupled to the artificial capsule so that the ciliary muscle can change or control the distance between the one or more lenses, allowing for improved vision.

[0072] In some embodiments, the device includes one or more fixation members extending forward from the outer surface of the device. In some embodiments, the one or more fixation members are disposed on the anterior surface of the device. In some embodiments, the one or more fixation members are disposed on the lateral wall of the device. In some embodiments, the one or more fixation members are disposed on the posterior surface of the device. In some embodiments, the one or more fixation members are disposed on a surface between the anterior and lateral wall of the device. In some embodiments, the one or more fixation members are disposed on a surface between the posterior and lateral wall of the device. In some embodiments, the one or more fixation members include one or more protrusions extending outward from the outer surface of the device. In some embodiments, the one or more protrusions include a rounded surface to avoid causing irritation and / or inflammation and / or other damage to ocular tissue, e.g., the inner surface of the lens capsule. In some embodiments, the one or more protrusions include one or more openings for receiving sutures that allow for fixation of the one or more protrusions to ocular tissue, e.g., the ciliary muscle. In some embodiments, the one or more fixation members can be inserted into an area of ​​the eye, e.g., the ciliary sulcus of the eye. In some embodiments, the one or more fixation members can be inserted into the ciliary sulcus of the eye via the anterior capsule of the eye. In some embodiments, the one or more fixation members can be inserted into the ciliary sulcus of the eye by forming one or more microrhexises in the anterior capsule of the eye, the formed microrhexises being configured to receive the one or more fixation members of the device to secure the device to the eye. In some embodiments, the ciliary muscle can move the one or more fixation members, causing expansion and / or contraction of the device.In some embodiments, the expansion and / or contraction can cause the device to expand and / or contract laterally between the side walls of the eye, and in some embodiments, the lateral expansion and / or contraction can cause the device to expand and / or contract anteriorly and / or posteriorly, e.g., the profile of the device can become more circular and / or elliptical. In some embodiments, the expansion and / or contraction of the device can apply pressure to other devices disposed within and / or on the device, e.g., an intraocular lens, which in some embodiments can change the properties of the other devices, e.g., changing the power and / or focus of the intraocular lens.

[0073] In some embodiments, a posterior lens and / or anterior lens can be inserted into and / or onto the device. In some embodiments, the posterior lens can be bonded or positioned adjacent to the posterior surface of the device. In some embodiments, the posterior lens is positioned adjacent to the inner or outer surface of the posterior section of the device. In some embodiments, the posterior lens is inserted into the eye before the device is inserted into the eye or at the same time as the device, and in some embodiments, the posterior lens is held in place by compressive forces exerted on the posterior lens by the outward expansion of the device and / or by a lens capsule that fits around the posterior lens and device. In some embodiments, the anterior lens can be bonded or positioned adjacent to the anterior surface of the device. In some embodiments, the anterior lens is positioned adjacent to the inner or outer surface of the anterior section of the device. In some embodiments, the anterior lens is inserted into the eye after the device is inserted into the eye or at the same time as the device, and in some embodiments, the anterior lens is held in place by compressive forces exerted on the anterior lens by the outward expansion of the device and / or by a lens capsule that fits around the anterior lens and device similar to a sock. In some embodiments, the posterior lens can be bonded or inserted into the posterior opening of the device. In some embodiments, an anterior lens may be coupled to or inserted into the anterior opening of the device. In some embodiments, expansion and / or contraction of the device can change the distance between the posterior and anterior lenses, thereby changing the magnification and / or power and / or focus of light entering the eye through the anterior and / or posterior lenses.

[0074] In some embodiments, the artificial capsule device is configured to receive an internal lens inside the housing of the artificial capsule device. In some embodiments, the artificial capsule device is configured to include one lens, and in some embodiments, the artificial capsule device is configured to include two or three lenses at the same time, for example, the artificial capsule device may be configured to include one lens at the rear of the artificial capsule device, one lens inside the artificial capsule device, and one lens positioned in the ciliary sulcus at the front of the artificial capsule device. In some embodiments, one or more of the anterior lens, internal lens, and / or posterior lens are configured to be phototunable, for example, by shining light on the lens, the lens can darken to shield the eye from bright light and / or ultraviolet light and / or other electromagnetic radiation wavelengths.

[0075] Figure 1 shows various perspective views of an example of an artificial capsule device 100. In some embodiments, device 100 includes features described with respect to, or modifications of, the device described in U.S. Patent No. 10,603,162, the entire contents of which are incorporated herein by reference. Figure 2 is a front perspective view of the exemplary artificial capsule device of Figure 1.

[0076] In some embodiments, device 100 includes features or modifications described with respect to the device described in U.S. Patent No. 9,358,103, the entirety of which is incorporated herein by reference. For example, device 100 can include an anterior side, a posterior side, and one or more sidewalls extending between the anterior and posterior sides, as well as a cavity or opening defined by the anterior side, the posterior side, and the one or more sidewalls. Device 100 can be configured to include one or more intraocular lenses, electronic devices, or other intraocular devices held within the cavity. The intraocular lenses can include any lens power and design currently known in the intraocular lens art. For example, these may include, but are not limited to, spherical lenses, aspherical lenses, wavefront lenses, convex lenses, concave lenses, extended depth of field lenses, pinhole or small aperture lenses, multifocal lenses (diffractive, refractive, zonal), toric lenses, accommodating lenses, ultraviolet (UV) filtering lenses, diffractive chromatic aberration reduction lenses, light tunable lenses (UV tunable, femtosecond phase wrapping), and optical powers ranging from any positive diopter value (e.g., including +35D or greater) to any negative diopter value (e.g., including -35D or less).

[0077] Additionally, in certain embodiments, device 100 includes one or more additional features. For example, device 100 can include a generally lenticular or lens-like shape, as opposed to a box-like design. In other words, the general shape of device 100 can more closely resemble the shape of the crystalline lens. The generally lenticular shape of device 100 can reduce the risk of negative and / or positive dysphotopsia. Negative dysphotopsia is a common problem in cataract surgery, commonly described by patients as a dark crescent on the temporal side of the field of vision, and is thought to be caused by an optical phenomenon known as total internal reflection or light obstruction. This phenomenon occurs either at the junction of the edge of the optic with the hollow, folded surrounding capsule, which forms a relatively flat surface, or because the capsule overlaps a portion of the optic (most commonly the nasal side). In embodiments in which implantable device 100 includes an overall lens-like configuration, the capsule can be held open, preventing the posterior and anterior capsules from fusing to form a relatively flat surface. More specifically, when light strikes a curved slice of device 100, which can be made of silicone, for example, it can travel through the curved slice rather than bouncing off and causing a negative shadow, as would typically be the case with a flat surface. This may be particularly true at the horizontal meridian, which intersects the 180-degree plane. Therefore, in some embodiments, device 100 does not include flat edges or surfaces. In other words, all surfaces of device 100 may be curved. Flat optical surfaces may promote total internal reflection, which is not found in the natural human lens or lens capsule. One goal of some embodiments described herein is to reduce negative dysphotopsia by not having flat optical surfaces. Certain embodiments may have additional features, such as opaque or translucent tints. This may further enhance the reduction of positive dysphotopsia by blocking stray light that may reflect from the boundaries or haptic edges of the intraocular lens.Depending on the color and opacity of the tint, it may also function as a type of artificial iris, blocking light that may penetrate iris transmission defects, traumatically altered irises, or surgical peripheral iridotomies, as well as preventing positive dysphotopsia and glare.

[0078] In some embodiments, substantially the entire device 100 can comprise silicone and / or a soft silicone polymer. Additionally, in certain embodiments, substantially the entire device 100 can comprise a flexible and / or elastic material. In this manner, device 100 can be foldable or collapsible for implantation into the eye through a small incision. Once inserted into the eye, device 100 can naturally unfold and self-expand to its expanded configuration, as shown in FIG. 1 . Device 100 can include one or more capsular areas. The one or more capsular areas can be adapted to receive and / or retain an intraocular lens. In some embodiments, one or more sidewalls can comprise a concave shape. For example, the inner surface of one or more sidewalls can form a cavity. The cavity can be configured to retain, for example, an intraocular lens.

[0079] In some embodiments, device 100 is constructed of a single-molded design. In other words, the entire device 100, or substantially the entire device 100, can be molded from a single material. For example, in some embodiments, substantially the entire device 100 can be molded from silicone using a silicone compression mold. In other embodiments, device 100, or any portion thereof, can be manufactured by 3D laser cutting, two-photon lithography, additive manufacturing, 3D printing, compression molding, and / or any combination of the foregoing manufacturing processes or others.

[0080] In some embodiments, device 100 can be inserted through an incision of about 1.5 mm to about 3 mm (e.g., about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2.0 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3.0 mm, ranges between such values, etc.).

[0081] Additionally, in some embodiments, the length of the major axis of device 100, or the length measured along the major axis of device 100 from the outermost edge of one sidewall to the outermost edge of another sidewall, may be about 9.65 mm. In other embodiments, the length of the major axis of device 100 may be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 100 may constitute the diameter 102 of device 100.

[0082] In some embodiments, the thickness of the silicone or other material of device 100 may be about 0.25 mm. In certain embodiments, the thickness of the silicone or other material of device 100 may be about 0.1 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, and / or within a range defined by two of the foregoing values.

[0083] In some embodiments, the thickness of the silicone or other material of device 100 varies in different portions of device 100. In other words, some portions of device 100 can be made of thinner material, while other portions of device 100 can be made of thicker material. For example, certain portions of the device that provide support for the anterior portion of device 100 can be made of thicker material for additional support.

[0084] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 104, which can be the diameter of the front opening and / or the rear opening.

[0085] In some embodiments, the shape and size of device 100 may minimize anterior, posterior, and / or radial protrusion into the lens capsule compared to conventionally used capsule devices. In some embodiments, device 100 may be smaller in certain dimensions, particularly toward the anterior and periphery of the device. In some embodiments, device 100 may be free of sharp and / or straight edges or sides to reduce friction between device 100 and the posterior surface of the iris of the eye. In some embodiments, the smaller size, reduced anterior, posterior, and / or radial protrusion into the lens capsule, and smoothed or curved edges may result in device 100 having an enhanced biocompatibility profile and / or may reduce inflammation caused by the device in the eye. In some embodiments, the unique shape and design of device 100 may result in reduced and / or elimination of inflammation in the eye (e.g., the anterior segment) upon insertion of the device. In some embodiments, the reduction and / or elimination of post-insertion inflammation due to the shape of device 100 may result in a reduction and / or elimination of the need for post-operative anti-inflammatory medications, such as, for example, steroids or nonsteroidal anti-inflammatory drugs (NSAIDs), and may also result in a reduction and / or elimination of device removal and / or replacement that may be necessary if inflammation cannot be reduced or eliminated.

[0086] The device 100 may be self-expanding to keep the capsule open. The device 100 may include at least three distinct planes. For example, the first plane may correspond to the posterior opening or end of the device, where an intraocular lens may be attached. The second plane may correspond to the anterior opening or end of the device, where another refractive surface or intraocular lens may be attached. In some embodiments, the device 100 is a symmetrical device, with the anterior and posterior openings determined by the position of the device 100 within the eye. The third plane may be located between the posterior and anterior ends, for example, along a ridge formed in the central portion, where another intraocular lens may be attached. In some embodiments, the central portion may include continuous lateral portions interposed between the anterior and posterior portions. In some embodiments, the continuous lateral portions project radially beyond the anterior and posterior portions. In some embodiments, the continuous lateral portions completely surround the sides of the housing structure, and the internal cavities of the continuous lateral portions form grooves for receiving intraocular lenses. In some embodiments, the central portion can include continuous lateral portions including an outer surface that includes a rounded bulge, the rounded bulge extending radially beyond the anterior and posterior portions. In some embodiments, the continuous lateral portions comprise an inner surface that includes a groove or ridge, at least a portion of which is formed at an acute or obtuse angle relative to the anterior and posterior portions.

[0087] In some embodiments, the artificial capsule device includes one or more orientation designation indicators or mechanisms 118 configured to function as markers indicating the direction and / or orientation of the artificial capsule device before, during, and / or after insertion into the eye. In some embodiments, the one or more orientation designation mechanisms 118 may be located on the anterior side, posterior side, and / or interior and / or exterior side walls of the artificial capsule device. In some embodiments, the one or more orientation designation mechanisms 118 may assist and / or enable a surgeon or medical professional to determine or recognize whether the artificial capsule device is in the correct orientation before, during, and / or after insertion into the eye.

[0088] In some embodiments, the one or more orientation indicators may include visual identification elements on the anterior, posterior, and / or interior and / or exterior side walls of the artificial capsule device. For example, the anterior, posterior, and / or interior and / or exterior side walls may differ based on various structural features, axis marks, color, shape, texture, hue, shading, brightness, contours, size, text indicators, engravings, icons, etc. In some embodiments, the one or more orientation indicators clarify the current orientation of the artificial capsule device before, during, and after insertion into the eye and serve as a measurement tool, for example, to measure rotational stability.

[0089] In some embodiments, the one or more orientation indicators include protrusions, bumps, protrusions, convexities, bulges, or other structures extending from the surface of the housing 100. In some embodiments, the one or more orientation indicators include visual markers such as holes or openings. In some embodiments, the visual markers can serve as reference points for measuring the rotational stability and position of the artificial capsule device 100 before, during, and / or after insertion into the eye. In some embodiments, the one or more orientation indicators 118 may extend radially inward from the diameter 104 of the anterior and / or posterior openings. However, in some embodiments, the one or more orientation indicators may extend radially inward or radially outward from any structure of the prosthetic device 100 and / or the intraocular lens coupled to the device. In some embodiments, it may be preferable for the one or more orientation indicators to extend radially inward from the anterior opening to provide optimal visibility to the surgeon and / or medical professional and avoid unnatural external protrusion into the lens capsule.

[0090] In some embodiments, the artificial capsule device 100 may include approximately two orientation designation indicators. In some embodiments, the number of orientation designation indicators 118 may be approximately 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 25, 30, 35, 40, 45, 50, 100, and / or within a range defined by two of the foregoing values. An exemplary orientation designation indicator 118 is shown in detail D of FIG. 1. In some embodiments, the orientation designation indicator 118 may include a thickness of approximately 0.10 mm. In some embodiments, the orientation designation indicator 118 may include a thickness between approximately 0.01 mm and 0.30 mm.

[0091] In some embodiments, an artificial capsule device configured to be inserted into the capsular bag of an eye after removal of the crystalline lens can include a housing structure 100 capable of housing one or more intraocular devices and / or refractive surfaces. In particular, the housing structure can include an anterior side. The anterior side includes an anterior opening, which can be elliptical, circular, arc-shaped, triangular, rectangular, polygonal, or other shape, as shown in the figures. The anterior opening can allow for at least one of insertion, removal, or replacement of an intraocular lens device. The anterior opening is further configured to be coupled to a lens so as to cover the anterior opening. The housing structure can include a posterior side. The posterior side includes a posterior opening, which can be elliptical, circular, arc-shaped, triangular, rectangular, polygonal, or other shape, as shown in the figures. The posterior opening can allow for at least one of insertion, removal, or replacement of an intraocular lens or device. The posterior opening is further configured to be coupled to an intraocular lens or device so as to cover the posterior opening. The housing structure can include continuous side portions interposed between the anterior and posterior portions. The continuous side portions protrude radially beyond the anterior and posterior portions. The continuous side portions completely surround the sides of the housing structure. The internal cavities of the continuous side portions form grooves or ridges for accommodating an intraocular lens or device, for example, within the anterior portion of the device. The continuous side portions may, in some embodiments, be free of openings, for example, along the lateral portions of the device. The housing structure 100 may be symmetrical about a plane at the midpoint of the continuous side portions between the anterior and posterior portions.

[0092] In some embodiments, the ridges or grooves may include one or more ribs 105. The ribs 105 are shown in detail along the ridges as Detail C in FIG. 1 . In some embodiments, the ribs may be configured to retain the intraocular lens within the device 100. For example, the ribs 105 may be configured to reduce mobility of the intraocular lens within the device 100 such that lens tilt, lens rotation, and / or decentration are reduced or eliminated. In some embodiments, the ribs 105 may include upper and lower surfaces and have a rib angle 120 between the upper and lower surfaces. In some embodiments, the rib angle may be approximately 100°. In some embodiments, the rib angle may be between approximately 10° and approximately 180°. For example, in some embodiments, the rib angle may be about 10°, about 15°, about 20°, about 25°, about 30°, about 35°, about 40°, about 45°, about 50°, about 55°, about 60°, about 65°, about 70°, about 75°, about 80°, about 85°, about 90°, about 95°, about 100°, about 105°, about 110°, about 115°, about 120°, about 125°, about 130°, about 135°, about 140°, about 145°, about 150°, about 155°, about 160°, about 165°, about 170°, about 175°, about 180°, or any value between the aforementioned values. In some embodiments, the rib angle 105 can be determined based on the thickness 108 of the device 100 along with the diameter 102.

[0093] In some embodiments, device 100 can include about 12 ribs. In some embodiments, device 100 can include about 1 to about 100 ribs, i.e., about 1 rib, about 2 ribs, about 3 ribs, about 4 ribs, about 5 ribs, about 6 ribs, about 7 ribs, about 8 ribs, about 9 ribs, about 10 ribs, about 11 ribs, about 12 ribs, about 13 ribs, about 14 ribs, about 15 ribs, about 16 ribs, about 17 ribs, about 18 ribs, about 19 ribs, about 20 ribs, about 21 ribs, about 22 ribs, about 23 ribs, about 24 ribs, about 25 ribs, about 26 ribs, or the like. Ribs, approx. 27 ribs, approx. 28 ribs, approx. 29 ribs, approx. 30 ribs, approx. 31 ribs, approx. 32 ribs, approx. 33 ribs, approx. 34 ribs, approx. 35 ribs, approx. 36 ribs, approx. 37 ribs, approx. 38 ribs, approx. 39 ribs, approx. 40 ribs, approx. 41 ribs, approx. 42 ribs, approx. 43 ribs, approx. 44 ribs, approx. 45 ribs, approx. 46 ribs, approx. 47 ribs, approx. 48 ribs, approx. 49 ribs, approx. 50 ribs, approx. 51 ribs Ribs, approx. 52 ribs, approx. 53 ribs, approx. 54 ribs, approx. 55 ribs, approx. 56 ribs, approx. 57 ribs, approx. 58 ribs, approx. 59 ribs, approx. 60 ribs, approx. 61 ribs, approx. 62 ribs, approx. 63 ribs, approx. 64 ribs, approx. 65 ribs, approx. 66 ribs, approx. 67 ribs, approx. 68 ribs, approx. 69 ribs, approx. 70 ribs, approx. 71 ribs, approx. 72 ribs, approx. 73 ribs, approx. 74 ribs, approx. 75 ribs, approx. 76 ribs , about 77 ribs, about 78 ribs, about 79 ribs, about 80 ribs, about 81 ribs, about 82 ribs, about 83 ribs, about 84 ribs, about 85 ribs, about 86 ribs, about 87 ribs, about 88 ribs, about 89 ribs, about 90 ribs, about 91 ribs, about 92 ribs, about 93 ribs, about 94 ribs, about 95 ribs, about 96 ribs, about 97 ribs, about 98 ribs, about 99 ribs, or about 100 ribs.

[0094] In some embodiments, device thickness 108 can constitute the maximum distance between the anterior side and posterior side of device 100. In some embodiments, device 100 thickness 108 can be about 2.00 mm. In some embodiments, device 100 thickness 108 can be about 1.50 mm. In some embodiments, device 100 thickness 108 can be about 0.5 mm to about 4.0 mm. In some embodiments, the thickness 108 of the device 100 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0095] In some embodiments, device 100 can include a ridge thickness 112 that includes the size of ridge locating ribs 105. In some embodiments, ridge thickness 112 can be about 0.40 mm. In some embodiments, ridge thickness 112 can be about 0.10 mm to about 1.00 mm. In some embodiments, ridge thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed within the ridge and secured by ribs 105.

[0096] In some embodiments, device 100 may include an inner thickness 110 that defines the distance between the inner surface of the sidewall at the front opening and the inner surface of the sidewall at the rear opening. In some embodiments, inner thickness 110 may be approximately 1.48 mm.

[0097] In some embodiments, device 100 can include an inner diameter 106 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 106 can be about 9.15 mm. In some embodiments, inner diameter can be about 5.00 mm to about 15.00 mm.

[0098] In some embodiments, the sidewall of the front portion of device 100 and the sidewall of the rear portion of device 100 can form a sidewall angle 124 formed on a ridge of device 100. In some embodiments, sidewall angle 124 can be about 34°. In some embodiments, sidewall angle 124 can be about 57°. In some embodiments, sidewall angle 124 can be between about 10° and about 180°. For example, in some embodiments, sidewall angle 124 may be about 10°, about 15°, about 20°, about 25°, about 30°, about 35°, about 40°, about 45°, about 50°, about 55°, about 60°, about 65°, about 70°, about 75°, about 80°, about 85°, about 90°, about 95°, about 100°, about 105°, about 110°, about 115°, about 120°, about 125°, about 130°, about 135°, about 140°, about 145°, about 150°, about 155°, about 160°, about 165°, about 170°, about 175°, about 180°, or any value between the aforementioned values. In some embodiments, sidewall angle 124 may be determined based on thickness 108 of device 100 along with diameter 102.

[0099] In some embodiments, the device cavity can include a volume for maintaining the shape and size of the lens capsule. This volume can include a tapered confinement area formed by angled sidewalls, where the sidewalls taper into the cavity at the anterior and posterior openings. In some embodiments, the taper can form a curvature in the sidewall adjacent the anterior and posterior openings. The curvature of the sidewall can provide a smoothed edge and reduce the effects of accidental contact with the posterior surface of the iris of the eye or pressure transmitted through the lens capsule and applied to the posterior surface of the iris of the eye. In some embodiments, the taper length 114 can define the distance between the outer surface of the sidewall at its anterior-most / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can include a curved surface 122 and a curved surface 116 at the ridge and opening, respectively. The curved shape of the sidewall can contribute to reducing postoperative complications through minimizing contact or the severity of contact between the device 100 and the iris. Detail B shows the curved shape of the sidewalls of device 100 near the opening.

[0100] Figures 3-30 illustrate other exemplary artificial capsule devices according to some embodiments herein. The embodiments of Figures 2-30 may include some or all of the features of the devices and device 100 described in U.S. Patent No. 10,603,162. Additionally, the embodiments of Figures 2-30 may include one or more additional features.

[0101] FIG. 3 illustrates another exemplary artificial capsule device according to some embodiments of the present disclosure. FIG. 4 illustrates a front perspective view of the exemplary artificial capsule device of FIG. 3. In device 300 of FIGS. 3-4, the sidewalls of the front portion of device 300 and the sidewalls of the rear portion of device 300 can form a sidewall angle 324 formed on a raised portion of device 300. In some embodiments, sidewall angle 324 can be smaller than that of device 100. In some embodiments, this smaller sidewall angle can reduce the overall thickness and profile of device 300 relative to device 100. In this manner, device 300 can be made smaller and used where a smaller profile is required depending on the patient's needs.

[0102] In some embodiments, the length of the major axis of device 300, or the length measured along the major axis of device 300 from the outermost edge of one sidewall to the outermost edge of another sidewall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 300 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 300 can constitute the diameter 302 of device 300.

[0103] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 304, which can be the diameter of the front opening and / or the rear opening.

[0104] In some embodiments, device 300 can include ridges or grooves, including one or more ribs 305. Ribs 305 are shown in detail along the ridges as Detail C in FIG. 3 . In some embodiments, ribs can be configured to retain an intraocular lens within device 300. For example, ribs 305 can be configured to reduce intraocular lens mobility within device 300 such that lens tilt, lens rotation, and / or decentration are reduced or eliminated. In some embodiments, ribs 305 can include upper and lower surfaces and have a rib angle 320 between the upper and lower surfaces. In some embodiments, the rib angle can be approximately 100°. In some embodiments, the rib angle can be between approximately 10° and approximately 180°. For example, in some embodiments, the rib angle may be about 10°, about 15°, about 20°, about 25°, about 30°, about 35°, about 40°, about 45°, about 50°, about 55°, about 60°, about 65°, about 70°, about 75°, about 80°, about 85°, about 90°, about 95°, about 100°, about 105°, about 110°, about 115°, about 120°, about 125°, about 130°, about 135°, about 140°, about 145°, about 150°, about 155°, about 160°, about 165°, about 170°, about 175°, about 180°, or any value between the aforementioned values. In some embodiments, the rib angle 305 can be determined based on the thickness 308 of the device 300 along with the diameter 302.

[0105] In some embodiments, thickness 308 of device 300 can constitute the maximum distance between the anterior side and posterior side of device 300. In some embodiments, thickness 308 of device 308 can be about 2.00 mm. In some embodiments, thickness 308 of device 300 can be about 1.50 mm. In some embodiments, thickness 308 of device 300 can be about 0.5 mm to about 4.0 mm. In some embodiments, the thickness 308 of the device may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0106] In some embodiments, the artificial capsule device 300 includes one or more orientation indicators or mechanisms 318 configured to function as markers indicating the direction and / or orientation of the artificial capsule device before, during, and / or after insertion into the eye. In some embodiments, the one or more orientation mechanisms 318 may be located on the anterior side, posterior side, and / or interior and / or exterior sidewalls of the artificial capsule device. In some embodiments, the one or more orientation mechanisms 318 may assist and / or enable a surgeon or medical professional to determine or recognize whether the artificial capsule device is in the correct orientation before, during, and / or after insertion into the eye. The orientation indicator or mechanism 318 may include features similar or identical to those discussed in connection with the orientation indicator or mechanism 118 of FIG. 1.

[0107] In some embodiments, device 300 may include an inner thickness 310 that defines the distance between the inner surface of the sidewall at the front opening and the inner surface of the sidewall at the rear opening. In some embodiments, inner thickness 310 may be about 0.98 mm.

[0108] In some embodiments, the taper length 314 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can include a curved surface 322 and a curved surface 316 at the ridge and opening, respectively. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 300 and the iris. The curved shape of the sidewall of the device 300 near the opening is shown in Detail B.

[0109] In some embodiments, device 300 can include an inner diameter 306 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 306 can be about 9.15 mm. In some embodiments, the inner diameter can be between about 5.00 mm and about 15.00 mm.

[0110] In some embodiments, device 300 can include a ridge thickness 312 that configures the size of ridge positioning ribs 305. In some embodiments, ridge thickness 312 can be about 0.40 mm. In some embodiments, ridge thickness 312 can be about 0.10 mm to about 1.00 mm. In some embodiments, the ridge thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed on the ridge and secured by ribs 305.

[0111] FIG. 5 illustrates another exemplary artificial capsule device according to some embodiments of the present disclosure. In device 500 of FIG. 5, the sidewall of the anterior portion of device 500 and the sidewall of the posterior portion of device 500 may form a sidewall angle 524 formed in a slot in device 500. In some embodiments, sidewall angle 524 may be larger than that of device 100 and device 300. For example, the sidewall angle may be approximately 75° or even larger. Furthermore, device 500 may not include a rib such as rib 105 or rib 305. Instead, device 500 may include a slot in the device cavity configured to secure an intraocular lens therein.

[0112] In some embodiments, the length of the major axis of device 500, or the length measured along the major axis of device 500 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 500 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 500 can constitute the diameter 502 of device 500.

[0113] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 504, which can be the diameter of the front opening and / or the rear opening.

[0114] In some embodiments, the taper length 514 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can include curved surfaces 522 and 516 at the slot and opening, respectively. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 500 and the iris. The curved shape of the sidewall of the device 500 near the opening is shown in Detail B.

[0115] In some embodiments, device 500 can include an inner diameter 506 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 506 can be about 9.15 mm. In some embodiments, the inner diameter can be between about 5.00 mm and about 15.00 mm.

[0116] In some embodiments, device 500 can include a slot thickness 512 that configures the size of the slot. In some embodiments, slot thickness 512 can be about 0.40 mm. In some embodiments, slot thickness 512 can be about 0.10 mm to about 1.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0117] In some embodiments, thickness 508 of device 500 can constitute the maximum distance between the anterior side and posterior side of device 500. In some embodiments, thickness 508 of device 508 can be about 2.50 mm. In some embodiments, thickness 508 of device 500 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 508 of the device may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0118] FIG. 6 shows another exemplary artificial capsule device according to some embodiments of the present disclosure. In the device 600 of FIG. 6, the sidewalls at the front and rear portions of the device 600 may include one or more notches 626 that open the front and rear portions of the device 600 to the internal cavity. In some embodiments, six notches may be provided in the device 600. However, the number and shape of the notches are not limited. In some embodiments, the notches 626 may facilitate folding and expansion of the device or allow for the insertion of intraocular lenses of different shapes or sizes.

[0119] In some embodiments, the notch may be substantially triangular with a rounded or blunt tip, the tip including a width 628. In some embodiments, the tip may include a width 628 of about 0.25 mm. In some embodiments, the tip may include a width 628 of about 0.1 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the base of the notch may include a base width 630 of about 1.25 mm. In some embodiments, the base width 630 may be in the range of about 0.1 mm to about 3.00 mm. In some embodiments, the tip may include one or more rounded corners having a radius of about 0.13 mm. In some embodiments, the diameter 603 of the notch 626 may be about 8.5 mm, measured at the tip of the notch.

[0120] In some embodiments, the length of the major axis of device 600, or the length measured along the major axis of device 600 from the outermost edge of one sidewall to the outermost edge of another sidewall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 600 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 600 can constitute the diameter 602 of device 600.

[0121] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 604, which can be the diameter of the front opening and / or the rear opening.

[0122] In some embodiments, device 600 may include an inner thickness 610 that defines the distance between the inner surface of the sidewall at the front opening and the inner surface of the sidewall at the rear opening. In some embodiments, inner thickness 610 may be approximately 2.27 mm.

[0123] In some embodiments, the taper length 614 can define the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can define a curved surface 616 at the opening. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 600 and the iris. The curved shape of the sidewall of the device 600 near the opening is shown in Detail B.

[0124] In some embodiments, device 600 can include an inner diameter 606 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 606 can be about 9.15 mm. In some embodiments, inner diameter can be about 5.00 mm to about 15.00 mm.

[0125] In some embodiments, device 600 can include a slot thickness 612 that configures the size of the slot. In some embodiments, slot thickness 612 can be about 0.40 mm. In some embodiments, slot thickness 612 can be about 0.10 mm to about 1.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0126] In some embodiments, thickness 608 of device 600 can constitute the maximum distance between the anterior side and posterior side of device 600. In some embodiments, thickness 608 of device 600 can be about 2.80 mm. In some embodiments, thickness 608 of device 600 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 608 of the device 600 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0127] In some embodiments, device 600 may include an inner thickness 610 that defines the distance between the inner surface of the sidewall at the front opening and the inner surface of the sidewall at the rear opening. In some embodiments, inner thickness 610 may be approximately 2.27 mm.

[0128] FIG. 7 illustrates another exemplary artificial capsule device according to some embodiments of the present disclosure. In device 700 of FIG. 7, the sidewall of the anterior portion of device 700 and the sidewall of the posterior portion of device 700 can form a sidewall angle 724 formed in a slot in device 700. In some embodiments, sidewall angle 724 may be larger than that of device 100 and device 300. For example, the sidewall angle may be approximately 69° or even larger. Furthermore, device 700 may not include a rib such as rib 105 or rib 305. Instead, device 700 may include a slot in the device cavity configured to secure an intraocular lens therein.

[0129] In some embodiments, the length of the major axis of device 700, or the length measured along the major axis of device 700 from the outermost edge of one sidewall to the outermost edge of another sidewall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 700 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 700 can constitute the diameter 702 of device 700.

[0130] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 704, which can be the diameter of the front opening and / or the rear opening.

[0131] In some embodiments, the taper length 714 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can include curved surfaces 722 and 716 at the slot and opening, respectively. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 700 and the iris. The curved shape of the sidewall of the device 700 near the opening is shown in Detail B.

[0132] In some embodiments, device 700 can include an inner diameter 706 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 706 can be about 9.15 mm. In some embodiments, inner diameter can be between about 5.00 mm and about 15.00 mm.

[0133] In some embodiments, device 700 can include a slot thickness 712 that configures the size of the slot. In some embodiments, slot thickness 712 can be about 0.40 mm. In some embodiments, slot thickness 712 can be about 0.10 mm to about 1.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0134] In some embodiments, thickness 708 of device 700 can constitute the maximum distance between the anterior side and posterior side of device 700. In some embodiments, thickness 708 of device 700 can be about 2.21 mm. In some embodiments, thickness 708 of device 700 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 708 of the device 700 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0135] In some embodiments, device 700 may include an inner thickness 710 that defines the distance between the inner surface of the sidewall at the front opening and the inner surface of the sidewall at the rear opening. In some embodiments, inner thickness 710 may be approximately 2.27 mm.

[0136] FIG. 8 shows another exemplary artificial capsule device according to some embodiments of the present disclosure. In the device 800 of FIG. 8, the sidewalls of the front and rear sections of the device 800 can include one or more notches 826 that open the front and rear sections of the device 800 to the internal cavity. In some embodiments, there may be six notches in the device 800. However, the number and shape of the notches are not limited. In some embodiments, the notches 826 can facilitate folding and expanding the device or allow for the insertion of intraocular lenses of different shapes or sizes.

[0137] In some embodiments, the notch may be substantially triangular with a rounded or blunt tip, the tip including a width 828. In some embodiments, the tip may include a width 828 of about 0.19 mm. In some embodiments, the tip may include a width 828 of about 0.1 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the base of the notch may include a base width 830 of about 0.98 mm. In some embodiments, the base width 830 may be in the range of about 0.1 mm to about 3.00 mm. In some embodiments, the tip may include one or more rounded corners having a radius of about 0.10 mm. In some embodiments, the diameter 803 of the notch 826 may be about 8.00 mm, measured at the tip of the notch.

[0138] In some embodiments, the length of the major axis of device 800, or the length measured along the major axis of device 800 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 800 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 800 can constitute the diameter 802 of device 800.

[0139] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 804, which can be the diameter of the front opening and / or the rear opening.

[0140] In some embodiments, device 800 may include an inner thickness 810 that defines the distance between the inner surface of the sidewall at the front opening and the inner surface of the sidewall at the rear opening. In some embodiments, inner thickness 810 may be approximately 2.27 mm.

[0141] In some embodiments, the taper length 814 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can include a curved surface 816 at the opening. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 800 and the iris. The curved shape of the sidewall of the device 800 near the opening is shown in Detail B.

[0142] In some embodiments, device 800 can include an inner diameter 806 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 806 can be about 9.15 mm. In some embodiments, inner diameter can be between about 5.00 mm and about 15.00 mm.

[0143] In some embodiments, device 800 can include a slot thickness 812 that configures the size of the slot. In some embodiments, slot thickness 812 can be about 0.80 mm. In some embodiments, slot thickness 812 can be about 0.10 mm to about 1.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0144] In some embodiments, thickness 808 of device 800 can constitute the maximum distance between the anterior side and posterior side of device 800. In some embodiments, thickness 808 of device 800 can be about 2.80 mm. In some embodiments, thickness 808 of device 800 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 808 of the device 800 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0145] FIG. 9 shows another exemplary artificial capsule device according to some embodiments of the present disclosure. In the device 900 of FIG. 9, the sidewalls of the anterior portion of the device 900 and the posterior portion of the device 900 may include one or more notches 926 that open the anterior and posterior portions of the device 900 to the internal cavity. In some embodiments, the device 900 may have six notches. However, the number and shape of the notches are not limited. In some embodiments, the notches 926 may facilitate folding and expanding the device and allow for the insertion of intraocular lenses of different shapes or sizes.

[0146] In some embodiments, the notch may be substantially triangular with a rounded or blunt tip, the tip including a width 928. In some embodiments, the tip may include a width 928 of about 0.19 mm. In some embodiments, the tip may include a width 928 of about 0.1 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the base of the notch may include a base width 930 of about 0.98 mm. In some embodiments, the base width 930 may be in the range of about 0.1 mm to about 3.00 mm. In some embodiments, the tip may include one or more rounded corners having a radius of about 0.10 mm. In some embodiments, the diameter 903 of the notch 926 may be about 8.00 mm, measured at the tip of the notch.

[0147] In some embodiments, the length of the major axis of device 900, or the length measured along the major axis of device 900 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 900 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 900 can constitute the diameter 902 of device 900.

[0148] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 904, which can be the diameter of the front opening and / or the rear opening.

[0149] In some embodiments, device 900 may include an inner thickness 910 that defines the distance between the inner surface of the sidewall at the front opening and the inner surface of the sidewall at the rear opening. In some embodiments, inner thickness 910 may be approximately 2.27 mm.

[0150] In some embodiments, the taper length 914 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface may include a curved surface 916 at the opening. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 900 and the iris. The curved shape of the sidewall of the device 900 near the opening is shown in Detail B.

[0151] In some embodiments, device 900 can include an inner diameter 906 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 906 can be about 9.15 mm. In some embodiments, the inner diameter can be between about 5.00 mm and about 15.00 mm.

[0152] In some embodiments, device 900 can include a slot thickness 912 that configures the size of the slot. In some embodiments, slot thickness 912 can be about 0.80 mm. In some embodiments, slot thickness 912 can be about 0.10 mm to about 1.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0153] In some embodiments, the thickness 908 of the device 900 can constitute the maximum distance between the anterior side and the posterior side of the device 900. In some embodiments, the thickness 908 of the device 900 can be about 2.80 mm. In some embodiments, the thickness 908 of the device 900 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 908 of the device 900 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0154] FIG. 10 illustrates another exemplary artificial capsule device according to some embodiments of the present disclosure. In the device 1000 of FIG. 10, the sidewalls of the front and rear sections of the device 1000 can include one or more notches that open the front and rear sections of the device 1000 to the internal cavity. In some embodiments, the device 1000 can have six notches. However, the number and shape of the notches are not limited. In some embodiments, the notches can facilitate folding and expansion of the device or allow for the insertion of intraocular lenses of different shapes or sizes. In some embodiments, the notches can be integrally formed with the front and rear openings to form a pointed star-shaped opening.

[0155] In some embodiments, the length of the major axis of device 1000, or the length measured along the major axis of device 1000 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 1000 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 1000 can constitute the diameter 1002 of device 1000.

[0156] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 1004, which can be the diameter of the front opening and / or the rear opening.

[0157] In some embodiments, the device 1000 may include an inner thickness 1010 that defines the distance between the inner surface of the side wall at the front opening and the inner surface of the side wall at the rear opening. In some embodiments, the inner thickness 1010 may be about 2.27 mm.

[0158] In some embodiments, the taper length 1014 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface may include a curved surface 1016 at the opening, respectively. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 1000 and the iris. The curved shape of the sidewall of the device 1000 near the opening is shown in Detail B.

[0159] In some embodiments, device 1000 can include an inner diameter 1006 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 1006 can be about 9.15 mm. In some embodiments, inner diameter can be between about 5.00 mm and about 15.00 mm.

[0160] In some embodiments, device 1000 can include a slot thickness 1012 that configures the size of the slot. In some embodiments, slot thickness 1012 can be about 0.80 mm. In some embodiments, slot thickness 1012 can be about 0.10 mm to about 1.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0161] In some embodiments, thickness 1008 of device 1000 can constitute the maximum distance between the anterior side and posterior side of device 1000. In some embodiments, thickness 1008 of device 1000 can be about 2.80 mm. In some embodiments, thickness 1008 of device 1000 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 1008 of the device 1000 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0162] FIG. 11 shows another exemplary artificial capsule device according to some embodiments of the present disclosure. In the device 1100 of FIG. 11, the sidewalls of the front section of the device 1100 and the sidewalls of the rear section of the device 1100 can form a slot in the device 1100. In some embodiments, the device 1100 can include a cylindrical middle section perpendicular to the front and rear openings. The device 1100 can include a slot within the device cavity configured to secure an intraocular lens therein.

[0163] In some embodiments, the length of the major axis of device 1100, or the length measured along the major axis of device 1100 from the outermost edge of one sidewall to the outermost edge of another sidewall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 1100 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 1100 can constitute the diameter 1102 of device 1100.

[0164] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute the diameter 1104 of the opening, which can be the diameter of the front opening and / or the rear opening.

[0165] In some embodiments, the taper length 1114 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can include a curved surface 1116 at the opening. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 1100 and the iris. The curved shape of the sidewall of the device 1100 near the opening is shown in Detail B.

[0166] In some embodiments, device 1100 can include an inner diameter 1106 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 1106 can be about 9.15 mm. In some embodiments, inner diameter can be between about 5.00 mm and about 15.00 mm.

[0167] In some embodiments, device 1100 can include a slot thickness 1112 that configures the size of the slot. In some embodiments, slot thickness 1112 can be about 0.40 mm. In some embodiments, slot thickness 1112 can be about 0.10 mm to about 1.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0168] In some embodiments, thickness 1108 of device 1100 can constitute the maximum distance between the anterior side and posterior side of device 1100. In some embodiments, thickness 1108 of device 1100 can be about 2.40 mm. In some embodiments, thickness 1108 of device 1100 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 1108 of the device 1100 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0169] In some embodiments, the device 1100 can include an inner thickness 1110 that defines the distance between the inner surface of the side wall at the front opening and the inner surface of the side wall at the rear opening. In some embodiments, the inner thickness 1110 can be about 1.87 mm.

[0170] FIG. 12 shows another exemplary artificial capsule device according to some embodiments of the present disclosure. In the device 1200 of FIG. 12, the sidewalls of the front section of the device 1200 and the sidewalls of the rear section of the device 1200 can form a slot in the device 1200. In some embodiments, the device 1200 can include a cylindrical middle section perpendicular to the front and rear openings. The device 1200 can include a slot within the device cavity configured to secure an intraocular lens therein.

[0171] In some embodiments, the length of the major axis of device 1200, or the length measured along the major axis of device 1200 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 1200 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 1200 can constitute the diameter 1202 of device 1200.

[0172] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 1204, which can be the diameter of the front opening and / or the rear opening.

[0173] In some embodiments, the taper length 1214 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can include a curved surface 1216 at the opening. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 1200 and the iris. The curved shape of the sidewall of the device 1200 near the opening is shown in Detail B.

[0174] In some embodiments, device 1200 can include an inner diameter 1206 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 1206 can be about 9.15 mm. In some embodiments, the inner diameter can be between about 5.00 mm and about 15.00 mm.

[0175] In some embodiments, device 1200 can include a slot thickness 1212 that configures the size of the slot. In some embodiments, slot thickness 1212 can be about 0.80 mm. In some embodiments, slot thickness 1212 can be about 0.10 mm to about 1.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0176] In some embodiments, thickness 1208 of device 1200 can constitute the maximum distance between the anterior side and posterior side of device 1200. In some embodiments, thickness 1208 of device 1200 can be about 2.80 mm. In some embodiments, thickness 1208 of device 1200 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 1208 of the device 1200 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0177] In some embodiments, device 1200 may include an inner thickness 1210 that defines the distance between the inner surface of the sidewall at the front opening and the inner surface of the sidewall at the rear opening. In some embodiments, inner thickness 1210 may be about 2.27 mm.

[0178] FIG. 13 shows another exemplary artificial capsule device according to some embodiments of the present disclosure. In device 1300 of FIG. 13, the sidewall of the anterior portion of device 1300 and the sidewall of the posterior portion of device 1300 can form a sidewall angle 1324 formed in a slot in device 1300. For example, the sidewall angle can be approximately 44°. Furthermore, device 1300 may not include a rib such as rib 105 or rib 305. Instead, device 1300 may include a slot in the device cavity configured to secure an intraocular lens therein.

[0179] In some embodiments, the length of the major axis of device 1300, or the length measured along the major axis of device 1300 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 1300 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 1300 can constitute the diameter 1302 of device 1300.

[0180] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 1304, which can be the diameter of the front opening and / or the rear opening.

[0181] In some embodiments, the taper length 1314 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can include curved surfaces 1322 and 1316 at the slot and opening, respectively. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 1300 and the iris. The curved shape of the sidewall of the device 1300 near the opening is shown in Detail B.

[0182] In some embodiments, device 1300 can include an inner diameter 1306 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 1306 can be about 9.15 mm. In some embodiments, inner diameter can be between about 5.00 mm and about 15.00 mm.

[0183] In some embodiments, device 1300 can include a slot thickness 1312 that configures the size of the slot. In some embodiments, slot thickness 1312 can be about 0.80 mm. In some embodiments, slot thickness 1312 can be about 0.10 mm to about 1.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0184] In some embodiments, thickness 1308 of device 1300 can constitute the maximum distance between the anterior side and posterior side of device 1300. In some embodiments, thickness 1308 of device 1300 can be about 2.50 mm. In some embodiments, thickness 1308 of device 1300 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 1308 of the device 1300 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0185] FIG. 14 shows another exemplary artificial capsule device according to some embodiments of the present disclosure. In device 1400 of FIG. 14, the sidewall of the anterior portion of device 1400 and the sidewall of the posterior portion of device 1400 may form a sidewall angle 1424 formed in a slot in device 1400. For example, the sidewall angle may be approximately 41°. Furthermore, device 1400 may not include a rib such as rib 105 or rib 305. Instead, device 1400 may include a slot in the device cavity configured to secure an intraocular lens therein.

[0186] In some embodiments, the length of the major axis of device 1400, or the length measured along the major axis of device 1400 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 1400 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 1400 can constitute the diameter 1402 of device 1400.

[0187] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 1404, which can be the diameter of the front opening and / or the rear opening.

[0188] In some embodiments, the taper length 1414 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface may include curved surfaces 1422 and 1416 at the slot and opening, respectively. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 1400 and the iris. The curved shape of the sidewall of the device 1400 near the opening is shown in Detail B.

[0189] In some embodiments, device 1400 can include an inner diameter 1406 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 1406 can be about 9.15 mm. In some embodiments, inner diameter can be about 5.00 mm to about 15.00 mm.

[0190] In some embodiments, device 1400 can include a slot thickness 1412 that configures the size of the slot. In some embodiments, slot thickness 1412 can be about 0.40 mm. In some embodiments, slot thickness 1412 can be about 0.10 mm to about 1.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0191] In some embodiments, thickness 1408 of device 1400 can constitute the maximum distance between the anterior side and posterior side of device 1400. In some embodiments, thickness 1408 of device 1400 can be about 2.00 mm. In some embodiments, thickness 1408 of device 1400 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 1408 of the device 1400 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0192] FIG. 15 shows another exemplary artificial capsule device according to some embodiments of the present disclosure. In device 1500 of FIG. 15, the sidewall of the anterior portion of device 1500 and the sidewall of the posterior portion of device 1500 can form a sidewall angle 1524 formed in a slot in device 1500. For example, the sidewall angle can be approximately 56°. Furthermore, device 1500 may not include a rib such as rib 105 or rib 305. Instead, device 1500 may include a slot in the device cavity configured to secure an intraocular lens therein.

[0193] In some embodiments, the length of the major axis of device 1500, or the length measured along the major axis of device 1500 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 1500 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 1500 can constitute the diameter 1502 of device 1500.

[0194] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 1504, which can be the diameter of the front opening and / or the rear opening.

[0195] In some embodiments, the taper length 1514 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface may include curved surfaces 1522 and 1516 at the slot and opening, respectively. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 1500 and the iris. The curved shape of the sidewall of the device 1500 near the opening is shown in Detail B.

[0196] In some embodiments, device 1500 can include an inner diameter 1506 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 1506 can be about 9.15 mm. In some embodiments, inner diameter can be between about 5.00 mm and about 15.00 mm.

[0197] In some embodiments, device 1500 can include a slot thickness 1512 that configures the size of the slot. In some embodiments, slot thickness 1512 can be about 0.40 mm. In some embodiments, slot thickness 1512 can be about 0.10 mm to about 1.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0198] In some embodiments, thickness 1508 of device 1500 can constitute the maximum distance between the anterior side and posterior side of device 1500. In some embodiments, thickness 1508 of device 1500 can be about 2.50 mm. In some embodiments, thickness 1508 of device 1500 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 1508 of the device 1500 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0199] FIG. 16 illustrates another exemplary artificial capsule device according to some embodiments of the present disclosure. In the device 1600 of FIG. 16, the sidewalls of the anterior portion of the device 1600 and the posterior portion of the device 1600 can form a slot in the device 1600. In some embodiments, the device 1600 can include a cylindrical middle portion perpendicular to the anterior and posterior openings. The device 1600 can include a slot in the device cavity configured to secure an intraocular lens therein. In the device 1600 of FIG. 16, the sidewalls of the anterior portion of the device 1600 and the posterior portion of the device 1600 can form a sidewall angle 1624 formed in the slot of the device 1600. For example, the sidewall angle can be approximately 27°. Furthermore, the device 1600 may not include a rib such as rib 105 or rib 305. Instead, the device 1600 can include a slot in the device cavity configured to secure an intraocular lens therein.

[0200] In some embodiments, the length of the major axis of device 1600, or the length measured along the major axis of device 1600 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 1600 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 1600 can constitute the diameter 1602 of device 1600.

[0201] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 1604, which can be the diameter of the front opening and / or the rear opening.

[0202] In some embodiments, the taper length 1614 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can include curved surfaces 1622 and 1616 at the slot and opening, respectively. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 1600 and the iris. The curved shape of the sidewall of the device 1600 near the opening is shown in Detail B.

[0203] In some embodiments, device 1600 can include an inner diameter 1606 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 1606 can be about 9.15 mm. In some embodiments, inner diameter can be about 5.00 mm to about 15.00 mm.

[0204] In some embodiments, device 1600 can include a slot thickness 1612 that configures the size of the slot. In some embodiments, slot thickness 1612 can be about 0.80 mm. In some embodiments, slot thickness 1612 can be about 0.10 mm to about 1.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0205] In some embodiments, thickness 1608 of device 1600 can constitute the maximum distance between the anterior side and posterior side of device 1600. In some embodiments, thickness 1608 of device 1600 can be about 2.00 mm. In some embodiments, thickness 1608 of device 1600 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 1608 of the device 1600 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0206] FIG. 17 illustrates another exemplary artificial capsule device according to some embodiments of the present disclosure. In device 1700 of FIG. 17, the sidewalls of the anterior portion of device 1700 and the posterior portion of device 1700 can form a slot in device 1700. In some embodiments, device 1700 can include a cylindrical middle portion perpendicular to the anterior and posterior openings. Device 1700 can include a slot in the device cavity configured to secure an intraocular lens therein. In device 1700 of FIG. 17, the sidewalls of the anterior portion of device 1700 and the posterior portion of device 1700 can form a sidewall angle 1724 formed in the slot of device 1700. For example, the sidewall angle can be approximately 58°. Furthermore, device 1700 may not include a rib such as rib 105 or rib 305. Instead, device 1700 can include a slot in the device cavity configured to secure an intraocular lens therein.

[0207] In some embodiments, the length of the major axis of device 1700, or the length measured along the major axis of device 1700 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 1700 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 1700 can constitute the diameter 1702 of device 1700.

[0208] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 1704, which can be the diameter of the front opening and / or the rear opening.

[0209] In some embodiments, the taper length 1714 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface may include curved surfaces 1722 and 1716 at the slot and opening, respectively. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 1700 and the iris. The curved shape of the sidewall of the device 1700 near the opening is shown in Detail B.

[0210] In some embodiments, device 1700 can include an inner diameter 1706 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 1706 can be about 9.15 mm. In some embodiments, the inner diameter can be between about 5.00 mm and about 15.00 mm.

[0211] In some embodiments, device 1700 can include a slot thickness 1712 that configures the size of the slot. In some embodiments, slot thickness 1712 can be about 0.80 mm. In some embodiments, slot thickness 1712 can be about 0.10 mm to about 1.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0212] In some embodiments, thickness 1708 of device 1700 can constitute the maximum distance between the anterior side and posterior side of device 1700. In some embodiments, thickness 1708 of device 1700 can be about 3.00 mm. In some embodiments, thickness 1708 of device 1700 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 1708 of the device 1700 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0213] FIG. 18 illustrates another exemplary artificial capsule device according to some embodiments of the present disclosure. In device 1800 of FIG. 18, the sidewalls of the anterior portion of device 1800 and the posterior portion of device 1800 can form a slot in device 1800. In some embodiments, device 1800 may have a cylindrical middle portion perpendicular to the anterior and posterior openings. Device 1800 may include a slot within the device cavity configured to secure an intraocular lens therein. In device 1800 of FIG. 18, the sidewalls of the anterior portion of device 1800 and the posterior portion of device 1800 can form a sidewall angle 1824 formed in the slot of device 1800. For example, the sidewall angle may be approximately 69°. Furthermore, device 1800 may not include ribs such as ribs 105 and 305. Instead, device 1800 may include a slot within the device cavity configured to secure an intraocular lens therein.

[0214] In some embodiments, the length of the major axis of device 1800, or the length measured along the major axis of device 1800 from the outermost edge of one sidewall to the outermost edge of another sidewall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 1800 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 1800 can constitute the diameter 1802 of device 1800.

[0215] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 1804, which can be the diameter of the front opening and / or the rear opening.

[0216] In some embodiments, the taper length 1814 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can include curved surfaces 1822 and 1816 at the slot and opening, respectively. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 1800 and the iris. The curved shape of the sidewall of the device 1800 near the opening is shown in Detail B.

[0217] In some embodiments, device 1800 can include an inner diameter 1806 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 1806 can be about 9.15 mm. In some embodiments, the inner diameter can be between about 5.00 mm and about 15.00 mm.

[0218] In some embodiments, device 1800 can include a slot thickness 1812 that configures the size of the slot. In some embodiments, slot thickness 1812 can be about 0.40 mm. In some embodiments, slot thickness 1812 can be about 0.10 mm to about 1.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0219] In some embodiments, thickness 1808 of device 1800 can constitute the maximum distance between the anterior side and posterior side of device 1800. In some embodiments, thickness 1808 of device 1800 can be about 3.00 mm. In some embodiments, thickness 1808 of device 1800 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 1808 of the device 1800 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0220] FIG. 19 illustrates another exemplary artificial capsule device according to some embodiments of the present disclosure. In device 1900 of FIG. 19, the sidewalls of the anterior portion of device 1900 and the posterior portion of device 1900 can form a slot in device 1900. In some embodiments, device 1900 can include a cylindrical middle portion perpendicular to the anterior and posterior openings. Device 1900 can include a slot within the device cavity configured to secure an intraocular lens therein. In device 1900 of FIG. 19, the sidewalls of the anterior portion of device 1900 and the posterior portion of device 1900 can form a sidewall angle 1924 formed in the slot of device 1900. For example, the sidewall angle can be approximately 91°. Additionally, device 1900 may not include ribs such as ribs 105 and 305. Instead, device 1900 can include a slot within the device cavity configured to secure an intraocular lens therein.

[0221] In some embodiments, the length of the major axis of device 1900, or the length measured along the major axis of device 1900 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 1900 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 1900 can constitute the diameter 1902 of device 1900.

[0222] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 1904, which can be the diameter of the front opening and / or the rear opening.

[0223] In some embodiments, the taper length 1914 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can include curved surfaces 1922 and 1916 at the slot and opening, respectively. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 1900 and the iris. The curved shape of the sidewall of the device 1900 near the opening is shown in Detail B.

[0224] In some embodiments, device 1900 can include an inner diameter 1906 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 1906 can be about 9.15 mm. In some embodiments, inner diameter can be between about 5.00 mm and about 15.00 mm.

[0225] In some embodiments, device 1900 can include a slot thickness 1912 that configures the size of the slot. In some embodiments, slot thickness 1912 can be about 1.40 mm. In some embodiments, slot thickness 1912 can be between about 0.10 mm and about 2.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0226] In some embodiments, thickness 1908 of device 1900 can constitute the maximum distance between the anterior side and posterior side of device 1900. In some embodiments, thickness 1908 of device 1900 can be about 3.00 mm. In some embodiments, thickness 1908 of device 1900 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 1908 of the device 1900 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0227] FIG. 20 illustrates another exemplary artificial capsule device according to some embodiments of the present disclosure. In device 2000 of FIG. 20, the sidewalls of the anterior portion of device 2000 and the posterior portion of device 2000 can form a slot in device 2000. In some embodiments, device 2000 can include a cylindrical middle portion perpendicular to the anterior and posterior openings. Device 2000 can include a slot in the device cavity configured to secure an intraocular lens therein. In device 2000 of FIG. 20, the sidewalls of the anterior portion of device 2000 and the posterior portion of device 2000 can form a sidewall angle 2024 formed in the slot of device 2000. For example, the sidewall angle can be approximately 111°. Additionally, device 2000 may not include ribs such as rib 105 or rib 305. Instead, device 2000 can include a slot in the device cavity configured to secure an intraocular lens therein.

[0228] In some embodiments, the length of the major axis of device 2000, or the length measured along the major axis of device 2000 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 2000 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 2000 can constitute the diameter 2002 of device 2000.

[0229] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 2004, which can be the diameter of the front opening and / or the rear opening.

[0230] In some embodiments, the taper length 2014 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface may include curved surfaces 2022 and 2016 at the slot and opening, respectively. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 2000 and the iris. The curved shape of the sidewall of the device 2000 near the opening is shown in Detail B.

[0231] In some embodiments, device 2000 can include an inner diameter 2006 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 2006 can be about 9.15 mm. In some embodiments, the inner diameter can be between about 5.00 mm and about 15.00 mm.

[0232] In some embodiments, device 2000 can include a slot thickness 2012 that configures the size of the slot. In some embodiments, slot thickness 2012 can be about 0.40 mm. In some embodiments, slot thickness 2012 can be between about 0.10 mm and about 2.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0233] In some embodiments, thickness 2008 of device 2000 can constitute the maximum distance between the anterior side and posterior side of device 2000. In some embodiments, thickness 2008 of device 2000 can be about 2.50 mm. In some embodiments, thickness 2008 of device 2000 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 2008 of the device 2000 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0234] FIG. 21 illustrates another exemplary artificial capsule device according to some embodiments of the present disclosure. In device 2100 of FIG. 21, the sidewall of the anterior portion of device 2100 and the sidewall of the posterior portion of device 2100 can form a slot in device 2100. In some embodiments, device 2100 can include a cylindrical middle portion perpendicular to the anterior and posterior openings. Device 2100 can include a slot in the device cavity configured to secure an intraocular lens therein. In device 2100 of FIG. 21, the sidewall of the anterior portion of device 2100 and the sidewall of the posterior portion of device 2100 can form a sidewall angle 2124 formed in the slot in device 2100. For example, the sidewall angle can be approximately 91°. Additionally, device 2100 may not include ribs such as rib 105 or rib 305. Instead, device 2100 can include a slot in the device cavity configured to secure an intraocular lens therein.

[0235] In some embodiments, the length of the major axis of device 2100, or the length measured along the major axis of device 2100 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 9.65 mm. In other embodiments, the length of the major axis of device 2100 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 2100 can constitute the diameter 2102 of device 2100.

[0236] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute the diameter 2104 of the opening, which can be the diameter of the front opening and / or the rear opening.

[0237] In some embodiments, the taper length 2114 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can include curved surfaces 2122 and 2116 at the slot and opening, respectively. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 2100 and the iris. The curved shape of the sidewall of 2100 near the opening is shown in Detail B.

[0238] In some embodiments, device 2100 can include an inner diameter 2106 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 2106 can be about 9.15 mm. In some embodiments, the inner diameter can be between about 5.00 mm and about 15.00 mm.

[0239] In some embodiments, device 2100 can include a slot thickness 2112 that configures the size of the slot. In some embodiments, slot thickness 2112 can be about 0.40 mm. In some embodiments, slot thickness 2112 can be between about 0.10 mm and about 2.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0240] In some embodiments, thickness 2108 of device 2100 can constitute the maximum distance between the anterior side and posterior side of device 2100. In some embodiments, thickness 2108 of device 2100 can be about 2.00 mm. In some embodiments, thickness 2108 of device 2100 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 2108 of the device 2100 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0241] FIG. 22 shows another exemplary artificial capsule device according to some embodiments of the present disclosure. In the device 2200 of FIG. 22, the sidewalls of the front section of the device 2200 and the sidewalls of the rear section of the device 2200 can form a slot in the device 2200. In some embodiments, the device 2200 can include a cylindrical middle section perpendicular to the front and rear openings. The device 2200 can include a slot within the device cavity configured to secure an intraocular lens therein.

[0242] In some embodiments, the length of the major axis of device 2200, or the length measured along the major axis of device 2200 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 10.00 mm. In other embodiments, the length of the major axis of device 2200 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 2200 can constitute the diameter 2202 of device 2200.

[0243] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute the diameter 2204 of the opening, which can be the diameter of the front opening and / or the rear opening.

[0244] In some embodiments, the taper length 2214 can comprise the distance between the outer surface of the side wall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface may include a curved surface 2216 at the opening. The curved shape of the side wall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 2200 and the iris. The curved shape of the side wall of the device 2200 near the opening is shown in Detail B.

[0245] In some embodiments, device 2200 can include an inner diameter 2206 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 2206 can be about 9.50 mm. In some embodiments, the inner diameter can be between about 5.00 mm and about 15.00 mm.

[0246] In some embodiments, device 2200 can include a slot thickness 2212 that configures the size of the slot. In some embodiments, slot thickness 2212 can be about 0.40 mm. In some embodiments, slot thickness 2212 can be about 0.10 mm to about 2.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0247] In some embodiments, thickness 2208 of device 2200 can constitute the maximum distance between the anterior side and posterior side of device 2200. In some embodiments, thickness 2208 of device 2200 can be about 2.00 mm. In some embodiments, thickness 2208 of device 2200 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 2208 of the device 2200 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0248] FIG. 23 shows another exemplary artificial capsule device according to some embodiments of the present disclosure. In device 2300 of FIG. 23, the sidewalls of the anterior section of device 2300 and the posterior section of device 2300 can form a slot in device 2300. In some embodiments, device 2300 can include a rounded middle section that protrudes laterally outward from the anterior and posterior sections. In some embodiments, the rounded middle section can include a middle section length 2332 measured from the outside of the device. In some embodiments, middle section length 2332 can be approximately 1.08 mm. In some embodiments, the rounded middle section can include a middle section inner length 2334 measured from the interior of the device. In some embodiments, middle section inner length 2334 can be approximately 0.70 mm. Device 2300 can include a slot within the device cavity configured to secure an intraocular lens therein.

[0249] In some embodiments, the length of the major axis of device 2300, or the length measured along the major axis of device 2300 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 11.00 mm. In other embodiments, the length of the major axis of device 2300 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 2300 can constitute the diameter 2302 of device 2300.

[0250] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute the diameter 2304 of the opening, which can be the diameter of the front opening and / or the rear opening.

[0251] In some embodiments, the taper length 2314 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can include curved surfaces 2322 and 2316 at the slot and opening, respectively. The curved shape of the sidewall can contribute to reducing post-operative complications by minimizing contact or the severity of contact between the device 2300 and the iris. The curved shape of the sidewall of the device 2300 near the opening is shown in Detail B.

[0252] In some embodiments, device 2300 can include an inner diameter 2306 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 2306 can be about 10.00 mm. In some embodiments, the inner diameter can be between about 5.00 mm and about 15.00 mm.

[0253] In some embodiments, device 2300 can include a slot thickness 2312 that configures the size of the slot. In some embodiments, slot thickness 2312 can be about 0.40 mm. In some embodiments, slot thickness 2312 can be about 0.10 mm to about 2.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0254] In some embodiments, thickness 2308 of device 2300 can constitute the maximum distance between the anterior side and posterior side of device 2300. In some embodiments, thickness 2308 of device 2300 can be about 2.00 mm. In some embodiments, thickness 2308 of device 2300 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 2308 of the device 2300 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0255] FIG. 24 illustrates another exemplary artificial capsule device according to some embodiments of the present disclosure. In the device 2400 of FIG. 24, the sidewalls of the anterior section of the device 2400 and the posterior section of the device 2400 can form a slot in the device 2400. In some embodiments, the device 2400 can include a rounded middle section that protrudes laterally outward from the anterior and posterior sections. In some embodiments, the rounded middle section can include a middle section length 2432 measured from the outside of the device. In some embodiments, the middle section length 2432 can be approximately 1.17 mm. In some embodiments, the rounded middle section can include a middle section inner length 2434 measured from the interior of the device. In some embodiments, the middle section inner length 2434 can be approximately 0.70 mm. The device 2400 can include a slot within the device cavity configured to secure an intraocular lens therein.

[0256] In some embodiments, the length of the major axis of device 2400, or the length measured along the major axis of device 2400 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 10.50 mm. In other embodiments, the length of the major axis of device 2400 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 2400 can constitute the diameter 2402 of device 2400.

[0257] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 2404, which can be the diameter of the front opening and / or the rear opening. In some embodiments, the device may include a rim diameter 2436 that comprises the diameter of the device formed by the rim surrounding the front and rear openings. In some embodiments, the rim diameter 2436 may measure between about 5.0 mm and about 15.0 mm. In some embodiments, the rim diameter 2436 may be about 8.0 mm. In some embodiments, the rim may include a rim length that comprises the distance from the opening to the sidewall of the device. In some embodiments, the rim length may be between about 0.1 mm and about 1.0 mm. In some embodiments, the rim length may be about 0.46 mm.

[0258] In some embodiments, the taper length 2414 can comprise the distance between the outer surface of the sidewall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can include curved surfaces 2422 and 2416 at the slot and opening, respectively. The curved shape of the sidewall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 2400 and the iris. The curved shape of the sidewall of the device 2400 near the opening is shown in Detail B.

[0259] In some embodiments, device 2400 can include an inner diameter 2406 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 2406 can be about 9.75 mm. In some embodiments, the inner diameter can be between about 5.00 mm and about 15.00 mm.

[0260] In some embodiments, device 2400 can include a slot thickness 2412 that configures the size of the slot. In some embodiments, slot thickness 2412 can be about 0.40 mm. In some embodiments, slot thickness 2412 can be between about 0.10 mm and about 2.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0261] In some embodiments, thickness 2408 of device 2400 can constitute the maximum distance between the anterior side and posterior side of device 2400. In some embodiments, thickness 2408 of device 2400 can be about 2.00 mm. In some embodiments, thickness 2408 of device 2400 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 2408 of the device 2400 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0262] FIG. 25 illustrates another exemplary artificial capsule device according to some embodiments of the present disclosure. In the device 2500 of FIG. 25, the sidewalls of the anterior section of the device 2500 and the posterior section of the device 2500 can form a slot in the device 2500. In some embodiments, the device 2500 can include a rounded middle section that protrudes laterally outward from the anterior and posterior sections. In some embodiments, the rounded middle section can include a middle section length 2532 measured from the outside of the device. In some embodiments, the middle section length 2532 can be approximately 1.17 mm. In some embodiments, the rounded middle section can include a middle section inner length 2534 measured from the interior of the device. In some embodiments, the middle section inner length 2534 can be approximately 0.70 mm. The device 2500 can include a slot within the device cavity configured to secure an intraocular lens therein.

[0263] In some embodiments, the length of the major axis of device 2500, or the length measured along the major axis of device 2500 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 10.50 mm. In other embodiments, the length of the major axis of device 2500 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 2500 can constitute the diameter 2502 of device 2500.

[0264] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute the diameter 2504 of the opening, which can be the diameter of the front opening and / or the rear opening. In some embodiments, the device may include a rim diameter 2536 that comprises the diameter of the device formed by the rim surrounding the front and rear openings. In some embodiments, the rim diameter 2536 may measure between about 5.0 mm and about 15.0 mm. In some embodiments, the rim diameter 2536 may be about 7.0 mm. In some embodiments, the rim may include a rim length that comprises the distance from the opening to the sidewall of the device. In some embodiments, the rim length may be between about 0.1 mm and about 1.0 mm. In some embodiments, the rim length may be about 0.50 mm.

[0265] In some embodiments, the taper length 2514 can comprise the distance between the outer surface of the side wall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface can include a curved surface 2516 at the opening. The curved shape of the side wall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 2500 and the iris. The curved shape of the side wall of the device 2500 near the opening is shown in Detail B.

[0266] In some embodiments, device 2500 can include an inner diameter 2506 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 2506 can be about 9.75 mm. In some embodiments, the inner diameter can be between about 5.00 mm and about 15.00 mm.

[0267] In some embodiments, device 2500 can include a slot thickness 2512 that configures the size of the slot. In some embodiments, slot thickness 2512 can be about 0.40 mm. In some embodiments, slot thickness 2512 can be about 0.10 mm to about 2.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0268] In some embodiments, thickness 2508 of device 2500 can constitute the maximum distance between the anterior side and posterior side of device 2500. In some embodiments, thickness 2508 of device 2500 can be about 2.00 mm. In some embodiments, thickness 2508 of device 2500 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 2508 of the device 2500 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0269] FIG. 26 shows another exemplary artificial capsule device according to some embodiments of the present disclosure. In device 2600 of FIG. 26, the sidewalls of the anterior section of device 2600 and the posterior section of device 2600 can form a slot in device 2600. In some embodiments, device 2600 can include a rounded middle section that protrudes laterally outward from the anterior and posterior sections. In some embodiments, the rounded middle section can include a middle section inner length 2634 measured inside the device. In some embodiments, middle section inner length 2634 can be approximately 0.70 mm. Device 2600 can include a slot within the device cavity configured to secure an intraocular lens therein.

[0270] In some embodiments, the length of the major axis of device 2600, or the length measured along the major axis of device 2600 from the outermost edge of one side wall to the outermost edge of another side wall, may be about 10.50 mm. In other embodiments, the length of the major axis of device 2600 may be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 2600 may constitute the diameter 2602 of device 2600.

[0271] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 2604, which can be the diameter of the front opening and / or the rear opening.

[0272] In some embodiments, the taper length 2614 can comprise the distance between the outer surface of the side wall at its most anterior / posterior point and the outer surface at the anterior / posterior opening. In some embodiments, the outer surface may include a curved surface 2616 at the opening. The curved shape of the side wall can contribute to reducing post-operative complications through minimizing contact or the severity of contact between the device 2600 and the iris. The curved shape of the side wall of the device 2600 near the opening is shown in Detail B.

[0273] In some embodiments, device 2600 can include an inner diameter 2606 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 2606 can be about 9.50 mm. In some embodiments, inner diameter can be between about 5.00 mm and about 15.00 mm.

[0274] In some embodiments, device 2600 can include a slot thickness 2612 that configures the size of the slot. In some embodiments, slot thickness 2612 can be about 0.70 mm. In some embodiments, slot thickness 2612 can be about 0.10 mm to about 2.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0275] In some embodiments, thickness 2608 of device 2600 can constitute the maximum distance between the anterior side and posterior side of device 2600. In some embodiments, thickness 2608 of device 2600 can be about 2.00 mm. In some embodiments, thickness 2608 of device 2600 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 2608 of the device 2600 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0276] FIG. 27 shows another exemplary artificial capsule device according to some embodiments of the present disclosure. In the device 2700 of FIG. 27, the sidewalls of the anterior portion of the device 2700 and the posterior portion of the device 2700 may include one or more notches 2742 that open the anterior and posterior portions of the device 2700 to the internal cavity. In some embodiments, the device 2700 may have 10 notches. However, the number and shape of the notches are not limited. In some embodiments, the notches 2742 may facilitate folding and expansion of the device or allow for the insertion of intraocular lenses of different shapes or sizes.

[0277] In some embodiments, the notches 2742 can be substantially triangular with rounded or blunt tips, where the tips include a radius. In some embodiments, the tips can include a radius of about 0.15 mm. In some embodiments, the tips can include a radius of about 0.1 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, and / or a radius within a range defined by two of the foregoing values. In some embodiments, each notch 2742 can extend around the circular opening in about 36° sectors, although the angle can depend on the number of notches 2742. In some embodiments, the diameter 2704 of the notches 2742, measured at the tip of the notch 2742, can be about 6.97 mm.

[0278] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute the diameter 2744 of the opening, which can be the diameter of the front opening and / or the rear opening.

[0279] FIG. 28 shows another exemplary artificial capsule device according to some embodiments of the present disclosure. In device 2800 of FIG. 28, the sidewalls of the anterior section of device 2800 and the posterior section of device 2800 can form a slot in device 2800. In some embodiments, device 2800 can include a rounded middle section that protrudes laterally outward from the anterior and posterior sections. In some embodiments, the rounded middle section can include a middle section length 2832 measured on the outside of the device. In some embodiments, middle section length 2832 can be approximately 1.20 mm. Device 2800 can include a slot within the device cavity configured to secure an intraocular lens therein.

[0280] In some embodiments, the length of the major axis of device 2800, or the length measured along the major axis of device 2800 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 11.00 mm. In other embodiments, the length of the major axis of device 2800 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 2800 can constitute the diameter 2802 of device 2800.

[0281] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 2804, which can be the diameter of the front opening and / or the rear opening.

[0282] In some embodiments, device 2800 can include an inner diameter 2806 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 2806 can be about 9.50 mm. In some embodiments, the inner diameter can be between about 5.00 mm and about 15.00 mm.

[0283] In some embodiments, device 2800 can include a slot thickness 2812 that configures the size of the slot. In some embodiments, slot thickness 2812 can be about 0.67 mm. In some embodiments, slot thickness 2812 can be about 0.10 mm to about 2.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0284] In some embodiments, thickness 2808 of device 2800 can constitute the maximum distance between the anterior side and posterior side of device 2800. In some embodiments, thickness 2808 of device 2800 can be about 2.00 mm. In some embodiments, thickness 2808 of device 2800 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 2808 of the device 2800 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0285] In some embodiments, the device 2800 can include an inner thickness 2810 that defines the distance between the inner surface of the side wall at the front opening and the inner surface of the side wall at the rear opening. In some embodiments, the inner thickness 2810 can be about 1.48 mm.

[0286] FIG. 29 shows another exemplary artificial capsule device according to some embodiments of the present disclosure. In the device 2900 of FIG. 29, the sidewalls of the anterior section of the device 2900 and the posterior section of the device 2900 can form a slot in the device 2900. In some embodiments, the device 2900 can include a rounded middle section that protrudes laterally outward from the anterior and posterior sections. In some embodiments, the rounded middle section can include a middle section length 2932 measured on the outside of the device. In some embodiments, the middle section length 2932 can be approximately 1.17 mm. The device 2900 can include a slot within the device cavity configured to secure an intraocular lens therein.

[0287] In some embodiments, the length of the major axis of device 2900, or the length measured along the major axis of device 2900 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 11.00 mm. In other embodiments, the length of the major axis of device 2900 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 2900 can constitute the diameter 2902 of device 2900.

[0288] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute an opening diameter 2904, which can be the diameter of the front opening and / or the rear opening.

[0289] In some embodiments, device 2900 can include an inner diameter 2906 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 2906 can be about 9.50 mm. In some embodiments, the inner diameter can be between about 5.00 mm and about 15.00 mm.

[0290] In some embodiments, device 2900 can include a slot thickness 2912 that configures the size of the slot. In some embodiments, slot thickness 2912 can be about 0.67 mm. In some embodiments, slot thickness 2912 can be between about 0.10 mm and about 2.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0291] In some embodiments, thickness 2908 of device 2900 can constitute the maximum distance between the anterior side and posterior side of device 2900. In some embodiments, thickness 2908 of device 2900 can be about 2.50 mm. In some embodiments, thickness 2908 of device 2900 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 2908 of the device 2900 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0292] In some embodiments, the device 2900 can include an inner thickness 2910 that defines the distance between the inner surface of the side wall at the front opening and the inner surface of the side wall at the rear opening. In some embodiments, the inner thickness 2910 can be about 1.85 mm.

[0293] 30 shows another exemplary artificial capsule device according to some embodiments of the present specification. In the device 3000 of FIG. 30, the sidewall of the front section of the device 3000 and the sidewall of the rear section of the device 3000 can form a slot in the device 3000. In some embodiments, the device 3000 has a completely curved outer surface such that the device 3000 is disc-shaped.

[0294] In some embodiments, the length of the major axis of device 3000, or the length measured along the major axis of device 3000 from the outermost edge of one side wall to the outermost edge of another side wall, can be about 11.50 mm. In other embodiments, the length of the major axis of device 3000 can be about 5.00 mm, about 6.00 mm, about 7.00 mm, about 8.00 mm, about 9.00 mm, about 10.00 mm, about 11.00 mm, about 12.00 mm, about 13.00 mm, about 14.00 mm, about 15.00 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the length of the major axis of device 3000 can constitute the diameter 3002 of device 3000.

[0295] In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 5.00 mm. In certain embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 6.00 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 7.0 mm. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the width of the opening of the cavity formed by each end of the two side walls can constitute the diameter 3004 of the opening, which can be the diameter of the front opening and / or the rear opening.

[0296] In some embodiments, device 3000 can include an inner diameter 3006 that defines the distance between the inner surfaces of the sidewalls at the ridges. In some embodiments, inner diameter 3006 can be about 10.30 mm. In some embodiments, inner diameter can be about 5.00 mm to about 15.00 mm.

[0297] In some embodiments, device 3000 can include a slot thickness 3012 that configures the size of the slot. In some embodiments, slot thickness 3012 can be about 0.70 mm. In some embodiments, slot thickness 3012 can be about 0.10 mm to about 2.00 mm. In some embodiments, the slot thickness can be configured to reduce the likelihood of lens tilt with an intraocular lens placed in the slot.

[0298] In some embodiments, thickness 3008 of device 3000 can constitute the maximum distance between the anterior side and posterior side of device 3000. In some embodiments, thickness 3008 of device 3000 can be about 2.27 mm. In some embodiments, thickness 3008 of device 3000 can be between about 0.5 mm and about 4.0 mm. In some embodiments, the thickness 3008 of the device 3000 may be about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4 mm, or any value between the aforementioned values.

[0299] FIG. 31 illustrates an example of the interaction between the curvature of the side wall and the iris of the eye. The curvature of the side wall forms a recess in the side wall, which can reduce the amount and / or severity of contact between the device 3100 and the posterior surface of the iris 3101. In some embodiments, smoother contact between the device 3100 and the posterior surface of the iris 3101 can reduce or eliminate pigment dispersion and / or irritation that can be caused using other devices. In some embodiments, at least a portion of the outer surface of the side wall of a device herein may be curved, and at least a portion of the inner surface of the side wall may be straight. In some embodiments, the device 3100 can correspond to either the device 100 or the artificial capsule device shown in the figures. For example, the outer surface of the device 3100 can correspond to the outer surface of the device 100.

[0300] FIG. 32 is an exemplary diagram of an artificial capsule device in the eye. The artificial capsule device 3200 can comprise any of the devices described herein. The diagram shows an eye with a dilated pupil 3290 and a constricted pupil 3280. As the pupil constricts and dilates when viewing an object, the posterior surface of the iris may contact the device 3200. In some embodiments, the shape, size, and tapered surface of the devices described herein can reduce or mitigate the severity of contact between the iris and the device. As a result, postoperative complications can be minimized.

[0301] Figure 33 shows an example image of an artificial capsule device in the eye. The artificial capsule device can comprise device 100 or any of the other artificial capsule devices shown in the figure.

[0302] FIG. 34 illustrates another exemplary prosthetic device according to some embodiments herein. The device of FIG. 34 may include some or all of the features described with respect to the devices of FIGS. 1-33. In some embodiments, the prosthetic capsule device may include one or more tabs, notches, or ribs on the inner surface of the device. In some embodiments, the one or more tabs, notches, or ribs on the inner surface of the device may protrude inward into the central cavity of the device. In some embodiments, the one or more tabs, notches, or ribs on the inner surface of the device may be configured to mate, contact, bond, or otherwise interact with an intraocular lens or haptics of an intraocular lens. In some embodiments, the one or more tabs, notches, or ribs on the inner surface of the device may prevent rotation or translation of the intraocular lens within the device. Preventing rotation of the intraocular lens within the device is particularly important when using toric intraocular lenses, as the rotational position of the lens within the eye is important for the function of the toric lens. The size, shape, position, and orientation of the one or more tabs, notches, or ribs on the inner surface of the device are not limited. Preferably, one or more tabs, notches, or ribs on the inner surface of the device can be positioned to mate, contact, interface, or otherwise interact with an intraocular lens or haptics of an intraocular lens.

[0303] In some embodiments, in addition to one or more tabs, notches, or ribs on the inner surface of the device, the artificial capsule device may include one or more tabs, notches, or ribs on the outer surface of the device that protrude radially outward from the outer surface. In some embodiments, the one or more tabs, notches, or ribs on the outer surface of the device may contact or engage the surface of the lens capsule. In some embodiments, this contact between the one or more tabs, notches, or ribs and the lens capsule can prevent or eliminate rotation of the artificial capsule device within the eye. Again, preventing rotation is considered particularly important when inserting a toric intraocular lens into the artificial capsule device. The size, shape, position, and orientation of the one or more tabs, notches, or ribs on the outer surface of the device are not limited. However, in some embodiments, the one or more tabs, notches, or ribs on the outer surface of the device may be positioned at a radially outer position, such as along the midpoint of the device along the longitudinal axis, so that the one or more tabs, notches, or ribs can contact the lens capsule.

[0304] FIG. 35 illustrates another exemplary prosthetic device according to some embodiments of the present disclosure. In some embodiments, in addition to or as an alternative to one or more tabs, notches, or ribs on the outer surface of the device, the artificial capsule device may include one or more ridges extending along at least a portion of the outer surface of the device. For example, as illustrated in FIG. 35, one or more ridges may extend along the entire device, from the anterior opening to the posterior opening. However, in some embodiments, the ridges may extend only along a portion of the device in the longitudinal direction. Furthermore, while one or more ridges are illustrated as being present around the entire circumference of the outer sidewall of the device, the one or more ridges may be present around only a portion of the circumference. Similar to one or more tabs, notches, or ribs on the outer surface of the device, the one or more ridges may contact the surface of the lens capsule to prevent rotation and / or movement of the artificial capsule device within the eye. In some embodiments, in addition to or as an alternative to one or more tabs, notches, ribs, or ridges on the outer surface of the device, the outer surface of the device may include one or more textured surfaces. In some embodiments, the textured surface can enhance grip or friction with the lens capsule and can prevent or reduce migration or rotational movement of the device within the eye. In some embodiments, the textured surface can be formed using adhesives, nanostructures or microstructures formed on the outer surface, a separate material formed on the outer surface, or other methods known in the art.

[0305] FIG. 36 illustrates another exemplary prosthetic device and an exemplary intraocular lens therein, according to some embodiments of the present disclosure. In particular, FIG. 36 illustrates an artificial implant device incorporating an intraocular lens therein, wherein the haptics of the intraocular lens are locked within the capsule cavity with one or more tabs, notches, or ribs on the inner surface of the device. In some embodiments, the haptics of the intraocular lens or one or more notches in the haptics can mate, contact, bond, or otherwise interact with one or more tabs, notches, or ribs on the inner surface of the device. The shapes, sizes, positions, and orientations of the intraocular lens and haptics that can be coupled to one or more tabs, notches, or ribs on the inner surface of the device are not particularly limited. For illustrative purposes, additional intraocular lens and haptic shapes are illustrated in FIGS. 37-39. In some embodiments, disclosed herein are one or more "lock and key" kit configurations including an artificial capsule device and an intraocular lens that couples to one or more tabs, notches, or ribs on the inner surface of the device. FIG. 40 illustrates an exemplary injector cartridge for use in a method of inserting an intraocular device and / or an intraocular lens, according to some embodiments herein.

[0306] Accordingly, some embodiments herein are directed to a kit for use in an ophthalmic surgical procedure. The kit includes an artificial implant device for insertion into the capsular bag of an eye after cataract removal and an intraocular lens. In some embodiments, the artificial implant device may include one or more tabs, notches, or ribs on an inner surface of the device configured to mate with, contact, bond, or otherwise interact with one or more notches on the intraocular lens or haptics attached to the intraocular lens.

[0307] FIG. 40 illustrates an exemplary injector cartridge 4000 for use in a method for inserting an intraocular device and / or an intraocular lens according to some embodiments of the present disclosure. In some embodiments, the injector cartridge can be used to insert the device and / or intraocular lens into the eye during an ophthalmic surgical procedure. Existing injectors include single-use or reusable cartridges that facilitate the insertion of an ocular prosthetic device or an intraocular lens through a corneal incision in the eye. However, existing injectors have several drawbacks, such as the inability to insert an intraocular lens followed by an artificial capsule device without removing the injector from the corneal insertion. For example, an existing injector can be used to insert an artificial capsule device into the eye after cataract removal. After this insertion, the injector must be removed from the corneal incision to reset it, the intraocular lens must be inserted into the injector, and the injector must be reloaded and repositioned in the incision. This procedure is time-consuming and inefficient, and can pose additional risks to the patient's eye for surgical complications, particularly widening of the corneal incision.

[0308] The injector cartridge 4000 of FIG. 40 can be configured to insert both an artificial capsule device and an intraocular lens into the eye without removing the device from the corneal incision. In some embodiments, a single injector cartridge and push rod system is provided that can implant both an artificial capsule device and an intraocular lens with a single insertion. The left chamber 4002 can contain a capsule, and the right chamber 4004 can contain an intraocular lens. For example, as shown, the injector may include two or more loading chambers and / or channels, each of which communicates with a single distal injection chamber 4006. In some embodiments, the injector can be configured as a "double barrel" with two loading chambers (one for the artificial capsule device and one for the intraocular lens), further simplifying and speeding up implantation. In some embodiments, one or more gates 4008 are provided to prevent the artificial capsule device or intraocular lens from being pushed back into the opposite loading chamber. In some embodiments, a push rod, such as a screw push rod 4010, may be used to selectively load the artificial capsule device or the intraocular lens into a single distal injection chamber. In some embodiments, a foam-tip sponge 4012 is placed in the injector following the artificial capsule device and the intraocular lens to ensure that the artificial capsule device and the intraocular lens are properly placed in the eye.

[0309] In some embodiments, a surgical method for implanting an ocular prosthetic device and / or an intraocular lens into an eye is provided. The method includes inserting the ocular prosthetic device and the intraocular lens through a corneal incision in the eye using an injector system. In some embodiments, the method includes using a single injector cartridge and push rod system that allows for implantation of both the artificial capsule device and the intraocular lens in a single insertion. In some embodiments, the method includes using an injector that includes a "double barrel" configuration with two loading chambers (one for the artificial capsule device and one for the intraocular lens).

[0310] 41 illustrates another exemplary prosthetic device according to some embodiments herein. In some embodiments, the prosthetic device 4100 can include one or more haptics 4102 extending from the outer sidewall of the device 4100. In some embodiments, the one or more haptics 4102 can facilitate fixation of the device onto the sclera and can be implanted in patients with trauma or surgical complications that have caused loss of capsule support. In some embodiments, the haptics 4102 can prevent rotation of the prosthetic capsule device and ensure centering of the device within the capsule, especially in the case of an asymmetric capsule.

[0311] In some embodiments, the prosthetic devices described herein can support any intraocular lens known to those skilled in the art, and the intraocular lens can be bonded to or inserted into the device within the eye. Existing devices can only fix a specific matching intraocular lens to the sclera of the eye. However, using the artificial capsule device of FIG. 41 , any intraocular lens can be bonded to or inserted into the device, which is fixed to the sclera and serves as a platform for the intraocular lens. In some embodiments, the haptics and artificial capsule device provide scleral fixation and create an artificial replacement lens capsule into which various intraocular lenses can be bonded or inserted.

[0312] Additionally, the artificial capsule devices described herein can be tinted to prevent positive dysphotopsia and to cover iris defects due to trauma or laser peripheral iridotomies for angle closure glaucoma.

[0313] 42A is a schematic diagram of a kit 4200 for use in an ophthalmic surgical procedure. The kit 4200 can include an intraocular lens 4202, a prosthetic device 4204, and / or a drug delivery device 4206 or drug delivery implant. The intraocular lens 4202 can be an intraocular lens such as those described in U.S. Pat. Nos. 8,900,300, 9,414,907, 9,358,103, and 10,603,162, and / or any intraocular lens known to those skilled in the art. The prosthetic device 4202 can comprise any prosthetic device such as those described herein with reference to FIGS. 1-41.

[0314] 42B-42H are schematic illustrations of a drug delivery device 4206. The drug delivery device 4206 can include a profile 4206A and a length 4206B. The profile 4206A can be the shape of the drug delivery device 4206 when viewed from an end view or a cross-sectional view of the drug delivery device 4206, as shown in FIGS. 42C and 42G. In some embodiments, the profile 4206A can be a circle, a square, a rectangle, an oval, a triangle, a rounded triangle, a pentagon, a trapezoid, an ellipse, a semicircle, a hexagon, an octagon, a ring, a diamond, a star, and / or any other shape.

[0315] In some embodiments, the drug delivery device 4206 may be elongated such that the length 4206B of the drug delivery device 4206 may be significantly greater than the width 4206C of the profile 4206A of the drug delivery device 4206. For example, the drug delivery device 4206 may be shaped like a pool noodle. In some embodiments, the length 4206B may be 2 times, 3 times, 4 times, 5 times, 6 times, 7 times, 8 times, 9 times, 10 times, 11 times, 12 times, 13 times, 14 times, 15 times, 16 times, 17 times, 18 times, 19 times, 20 times, 25 times, 30 times, 40 times, 45 times, 50 times, 60 times, 70 times, 80 times, 90 times, 100 times, 150 times, 200 times the width of the profile 4206B, and / or any value between the aforementioned values. In some embodiments, the length 4206C of the drug delivery device 4206 can be about 1 mm, about 2 mm, about 3 mm, about 4 mm, about 5 mm, about 6 mm, about 7 mm, about 8 mm, about 9 mm, about 10 mm, about 15 mm, about 20 mm, about 25 mm, about 30 mm, about 35 mm, about 40 mm, about 50 mm, and / or any value between the aforementioned values. In some embodiments, the length 4206C of the drug delivery device 4206 can be about 28.5 mm.

[0316] The elongated shape of the drug delivery device 4206 may allow the drug delivery device 4206 to bend or curve along the length 4206B of the drug delivery device 4206. In some embodiments, the drug delivery device 4206 may bend or curve from a straight configuration to a ring configuration or a discontinuous ring configuration, as shown in FIG. 42D-F, to fit within an interior cavity of the prosthetic device 4204 such that the drug delivery device 4206 contacts an interior surface or sidewall of the prosthetic device 4204, as shown in FIG. 42H. In some embodiments, the drug delivery device 4206 may include a bias to be substantially straight, but once the drug delivery device 4206 is positioned within the prosthetic device 4204, the drug delivery device 4206 may assume the shape of the prosthetic device 4204, for example, a ring-like shape, or a substantially curved configuration, or a substantially circumferential configuration. In some embodiments, the drug delivery device 4206 can include a bias such that it is ring-like, or has a substantially curved configuration, or a substantially circumferential configuration, but when the drug delivery device 4206 is inserted and positioned through a delivery cannula, trocar, or injector, the drug delivery device 4206 can assume a substantially straight or linear configuration for insertion through a delivery cannula, trocar, or injector into the prosthetic device 4204. In some embodiments, the drug delivery device 4206 can form an arc such that the drug delivery device 4206 forms a portion of a ring or discontinuous circle.

[0317] In some embodiments, the outer diameter 4206E of the drug delivery device 4206 when the drug delivery device 4206 is in the ring configuration or the discontinuous ring configuration is about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm , about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, about 8.2 mm, about 8.4 mm, about 8.6 mm, about 8.8 mm, about 9.0 mm, about 9.2 mm, about 9.4 mm, about 9.6 mm, about 9.8 mm, about 10.0 mm, about 10.5 mm, about 11.0 mm, about 11.5 mm, about 12.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the outer diameter 4206F can be about 9.15 mm.

[0318] In some embodiments, the inner diameter 4206F of the drug delivery device 4206 when the drug delivery device 4206 is in the ring configuration or the discontinuous ring configuration can be about 3.0 mm, about 3.2 mm, about 3.4 mm, about 3.6 mm, about 3.8 mm, about 4.0 mm, about 4.2 mm, about 4.4 mm, about 4.6 mm, about 4.8 mm, about 5.0 mm, about 5.2 mm, about 5.4 mm, about 5.6 mm, about 5.8 mm, about 6.0 mm, about 6.2 mm, about 6.4 mm, about 6.6 mm, about 6.8 mm, about 7.0 mm, about 7.2 mm, about 7.4 mm, about 7.6 mm, about 7.8 mm, about 8.0 mm, and / or within a range defined by two of the foregoing values. In some embodiments, the inner diameter 4206F can be about 6.0 mm.

[0319] In some embodiments, the length 4206B of the drug delivery device 4206 can be equal to or approximately equal to the circumference of the internal cavity of the prosthetic device 4204, where the circumference of the internal cavity is the circumference of the prosthetic device 4204 where opposing sides of the inner surface of the prosthetic device 4204 are farthest apart or where the internal cavity of the prosthetic device 4204 has a largest diameter. In some embodiments, the length 4206B of the drug delivery device 4206 can be greater than the circumference of the internal cavity of the prosthetic device 4204 such that at least a portion of the drug delivery device 4206 overlaps when the drug delivery device 4206 is within the internal cavity of the prosthetic device 4204.

[0320] In some embodiments, the drug delivery device 4206 may be shaped and / or sized such that none of the drug delivery device 4206 blocks or overlaps an opening in the prosthetic device 4204 when the drug delivery device 4206 is in the internal cavity of the prosthetic device 4204. In some embodiments, the drug delivery device 4206 may be shaped and / or sized such that a portion of the drug delivery device 4206 blocks or overlaps an opening in the prosthetic device 4204 when the drug delivery device 4206 is in the internal cavity of the prosthetic device 4204. In some embodiments, the drug delivery device 4206 can occlude or overlap the diameter of the opening in the artificial implant device 4204 by about 0.1 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2.0 mm and / or any value between the aforementioned values.

[0321] In some embodiments, the length of the drug delivery device 4206 can be less than the perimeter of the internal cavity of the prosthetic device 4204. In these embodiments, one drug delivery device 4206 can be inserted into the internal cavity of the prosthetic device 4204, or two or more drug delivery devices 4206 can be inserted into the internal cavity of the prosthetic device. In some embodiments, the combined lengths 4206B of the two or more drug delivery devices 4206 can be equal to or greater than the perimeter of the internal cavity of the prosthetic device 4204, such that the two or more drug delivery devices 4206 collectively form a ring or circular shape. In some embodiments, the combined lengths 4206B of the two or more drug delivery devices 4206 can be less than the perimeter of the internal cavity of the prosthetic device, such that the two or more drug delivery devices 4206 form a portion or arc of a ring or circle.

[0322] In some embodiments, the drug delivery device 4206 can include one or more bioerodible materials. The bioerodible materials can include collagen, alginate, poly(lactic-co-glycolic acid) (PLGA), polyanhydrides, polycaprolactone, poly(trimethylene carbonate), polyphosphazene, and / or any other bioerodible material. In some embodiments, the drug delivery device 4206 can be non-bioerodible. In some embodiments, the drug delivery device 4206 can include silicone, vulcanized silicone, and / or a silicone polymer.

[0323] In some embodiments, the one or more bioerodible materials may be impregnated or infused with one or more agents. In some embodiments, the drug delivery device 4206 may be immersed in a solution containing one or more agents. In these embodiments, the one or more agents may be dissolved in a solvent that can swell the silicone. In some embodiments, the drug delivery device 4206 may be immersed in a solvent with the dissolved one or more agents. In some embodiments, the drug delivery device 4206 may be removed from the solvent with the dissolved one or more agents after a predetermined immersion period. In some embodiments, after the drug delivery device 4206 is removed from the solvent, the solvent may evaporate, leaving behind the one or more agents impregnated or infused within the drug delivery device 4206. In some embodiments, the drug delivery device 4206 has and / or can hold a volume of one or more medicaments of about 0.01 ml, about 0.02 ml, about 0.03 ml, about 0.04 ml, about 0.05 ml, about 0.06 ml, about 0.07 ml, about 0.08 ml, about 0.09 ml, about 0.10 ml, about 0.11 ml, about 0.12 ml, about 0.13 ml, about 0.14 ml, about 0.15 ml, about 0.16 ml, about 0.17 ml, about 0.18 ml, about 0.19 ml, about 0.20 ml, and / or any value between the aforementioned values. In some embodiments, the volume of the drug delivery device 4206 and / or the one or more medicaments is about 87.37 mm 3 may be.

[0324] In some embodiments, the drug delivery device 4206 can erode over a period of time. As the drug delivery device 4206 erodes, the drug delivery device 4206 can continuously release one or more drugs into the eye over a predetermined period of time. In some embodiments, the drug delivery device 4206 can include one or more drug release holes, eyelets, slits, and / or openings that allow the drug within the drug delivery device 4206 to flow from within the drug delivery device 4206 to outside of the drug delivery device 4206.

[0325] In some embodiments, the drug delivery device 4206 may contain anti-inflammatory drugs (NSAIDs, steroids), anti-fibrotic drugs (mitomycin), immunomodulatory drugs (cyclosporine, tacrolimus, methotrexate), antiviral drugs (ganciclovir, valacyclovir, acyclovir), antibiotics, antifungal drugs (voriconazole, natamycin, amphotericin B), anti-VEGF drugs (avastin, lucentis, eylea), and / or other drugs approved for intraocular administration and external administration via eye drops.

[0326] In some embodiments, the drug delivery device 4206 can include one or more holes, eyelets, slits, and / or openings 4206D. In some embodiments, the one or more holes, eyelets, slits, and / or openings 4206D allow the drug release device 4206 to be inserted into the prosthetic device 4204 using an injector. In some embodiments, the injector can be an injector such as those described herein with reference to FIG. 40 . In some embodiments, the injector can be an injector such as those described in U.S. Pat. Nos. 8,900,300, 9,414,907, 9,358,103, 10,603,162, and / or any injector known to those skilled in the art. In some embodiments, the injector can include a plunger push rod. In some embodiments, the injector can include a screw-feed push rod system. In some embodiments, the drug delivery device 4206 can be shaped like a capsular tension ring.

[0327] In some embodiments, as further described below with reference to Figures 43A and 43B, the drug delivery device 4206 may be coupled to and / or secured to an inner surface or side wall of the artificial device 4204 before the artificial device 4204 is inserted into the capsular bag, or the drug delivery device 4204 may be inserted into an internal cavity of the artificial device 4204 after the artificial device 4204 is inserted into the capsular bag.

[0328] 43A is a flowchart of a method 4300A for inserting the kit 4200 into the lens capsule. In some embodiments, an intraocular lens 4202 may be inserted or implanted into the lens capsule at step 4302A of the method 4300A. In some embodiments, an incision may be made in the cornea before inserting the intraocular lens 4202 into the lens capsule at step 4302A. In some embodiments, the intraocular lens 4202 may be inserted according to any of the methods disclosed herein and / or described in U.S. Pat. Nos. 8,900,300, 9,414,907, 9,358,103, and 10,603,162. In some embodiments, the intraocular lens 4202 may be inserted into the lens capsule such that the haptics of the intraocular lens 4202 are located outside the lens capsule.

[0329] In some embodiments, in step 4304A, the prosthetic device 4204 can be inserted into the capsular bag. In some embodiments, the prosthetic device 4204 can be inserted according to any of the methods disclosed herein and / or described in U.S. Pat. Nos. 8,900,300, 9,414,907, 9,358,103, and 10,603,162. In some embodiments, the prosthetic device 4204 can be inserted into the capsular bag such that the intraocular lens 4202 is located posterior to the posterior opening of the prosthetic device 4204. In some embodiments, the prosthetic device 4204 can be inserted into the capsular bag such that the intraocular lens 4202 fits within the posterior opening of the prosthetic device 4204. In some embodiments, the prosthetic device 4204 can be inserted into the capsular bag such that the intraocular lens 4202 is coupled to the posterior opening of the prosthetic device 4204.

[0330] In some embodiments, in step 4306A, the drug delivery device 4206 may be inserted into the internal cavity of the prosthetic device 4204. In some embodiments, in step 4306A, multiple drug delivery devices 4206 may be inserted into the prosthetic device 4204. In some embodiments, the drug delivery device 4206 may be inserted into the internal cavity of the prosthetic device 4204. In some embodiments, the drug delivery device 4206 may be inserted into the prosthetic device 4204 via an injector, as described above with reference to FIGS. 42A-42E . In some embodiments, the drug delivery device 4206 may be in a straight configuration when the drug delivery device 4206 is in the injector. In some embodiments, the drug delivery device 4206 may automatically bend or curve from the straight configuration into a ring configuration or a discontinuous ring configuration when the drug delivery device 4206 is inserted into the prosthetic device 4204.

[0331] In some embodiments, after the drug delivery device 4206 is inserted into the prosthetic device 4204 in step 4306A, the corneal incision may be sutured or closed according to any of the methods disclosed herein and / or described in U.S. Patent Nos. 8,900,300, 9,414,907, 9,358,103, and 10,603,162.

[0332] In embodiments in which the drug delivery device 4206 is bioerodible or biodegradable, step 4306A of method 4300A may be repeated such that at least a second drug delivery device 4206 may be inserted into the prosthetic device 4204 after the drug delivery device 4206 has been partially or completely eroded so that a portion of the drug in the drug delivery device 4206 has been released or all of the drug in the drug delivery device 4206 has been released.

[0333] In embodiments where the drug delivery device 4206 is not bioerodible or biodegradable, after a portion of the drug in the drug delivery device 4206 has been released, or after all of the drug in the drug delivery device 4206 has been released, the drug delivery device 4206 may be removed from within the prosthetic device 4206. In some embodiments, step 4306A of method 4300A may be repeated such that at least a second drug delivery device 4206 is inserted into the prosthetic device 4204.

[0334] 43B is a flowchart of a method 4300B for inserting the kit 4200 into the lens capsule. In some embodiments, the intraocular lens 4202 may be inserted or implanted into the lens capsule in step 4302B of the method 4300B. In some embodiments, an incision may be made in the cornea before inserting the intraocular lens 4202 into the lens capsule in step 4302B. In some embodiments, the intraocular lens 4202 may be inserted according to any of the methods disclosed herein and / or described in U.S. Pat. Nos. 8,900,300, 9,414,907, 9,358,103, and 10,603,162. In some embodiments, the intraocular lens 4202 may be inserted into the lens capsule such that the haptics of the intraocular lens 4202 are located outside the lens capsule.

[0335] In some embodiments, in step 4304B, the drug delivery device 4206 can be inserted into the internal cavity of the prosthetic device 4204. In some embodiments, step 4304B of method 4300B can be completed before the intraocular lens 4202 is inserted or implanted into the capsular bag in step 4302B, or step 4304B of method 4300B can be completed after the intraocular lens 4202 is inserted or implanted into the capsular bag in step 4302B. In some embodiments, the drug delivery device 4206 can be inserted into the internal cavity of the prosthetic device 4204 via an injector, as described above with reference to FIGS. 42A-42H . In some embodiments, the drug delivery device 4206 can be in a straight configuration when the drug delivery device 4206 is in the injector. In some embodiments, the drug delivery device 4206 can automatically bend or curve from the straight configuration to a ring configuration or a discontinuous ring configuration when the drug delivery device 4206 is inserted into the prosthetic device 4204. In some embodiments, the drug delivery device 4206 can be coupled to an inner surface of the prosthetic device 4204. In some embodiments, the drug delivery device 4206 can be part of the prosthetic device 4204 such that the drug delivery device 4206 is not detachable from the prosthetic device 4206.

[0336] In some embodiments, in step 4306B of method 4300B, the prosthetic device 4204 and the drug delivery device 4206 can be inserted into the lens capsule. In some embodiments, the prosthetic device 4204 and the drug delivery device 4206 can be inserted according to any of the methods disclosed herein and / or the methods described in U.S. Patent Nos. 8,900,300, 9,414,907, 9,358,103, and 10,603,162. In some embodiments, the prosthetic device 4204 and the drug delivery device 4206 can be inserted into the lens capsule such that the intraocular lens 4202 is located posterior to the posterior opening of the prosthetic device 4204. In some embodiments, the prosthetic device 4204 and the drug delivery device 4206 can be inserted into the lens capsule such that the intraocular lens 4202 fits within the posterior opening of the prosthetic device 4204. In some embodiments, the prosthetic device 4204 and the drug delivery device 4206 can be inserted into the capsular bag such that the intraocular lens 4202 is coupled to a posterior opening of the prosthetic device 4204. In some embodiments, the one or more intraocular lenses 4202 can be positioned anterior and / or posterior to the drug delivery device 4204. In some embodiments, the drug delivery device 4204 can be configured to secure the one or more intraocular lenses 4202 within or adjacent to a housing structure of the prosthetic device 4204.

[0337] In embodiments in which the drug delivery device 4206 is bioerodible or biodegradable, at least a second drug delivery device 4206 can be inserted into the interior volume of the prosthetic device 4204 after the drug delivery device 4206 has partially eroded or completely eroded so that a portion of the drug in the drug delivery device 4206 is released or all of the drug in the drug delivery device 4206 is released.

[0338] In embodiments where the drug delivery device 4206 is not bioerodible or biodegradable, after a portion of the drug in the drug delivery device 4206 has been released, or after all of the drug in the drug delivery device 4206 has been released, the drug delivery device 4206 may be removed from the interior volume of the prosthetic device 4204. In some embodiments, step 4306A of method 4300A may be repeated such that at least a second drug delivery device 4206 is inserted into the prosthetic device 4204.

[0339] In some embodiments, the prosthetic device 4204 and the drug delivery device 4206 can be removed from the capsular bag after a portion of the agent in the drug delivery device 4206 has been released or after all of the agent in the drug delivery device 4206 has been released. In some embodiments, at least a second prosthetic device 4204 and / or at least a second drug delivery device 4206 can be inserted into the capsular bag according to methods 4300A, 4300B described herein.

[0340] Although the drug delivery device 4206 is described herein as being inserted into the interior volume of the prosthetic device 4206, it is understood that the drug delivery device may be coupled to any location on or within the prosthetic device 4206, or any location within the capsular bag relative to the prosthetic device 4206, without departing from the scope of this disclosure.

[0341] 44A-44D are schematic diagrams of another artificial capsule device 4400 according to some embodiments of the present disclosure. In some embodiments, the artificial capsule device 4400 may include one or more fixation members 4402. In some embodiments, the one or more fixation members 4402 may be transcapsular. In some embodiments, the artificial capsule device 4400 may include four fixation members 4402. In some embodiments, the artificial capsule device 4400 may include two to eight fixation members 4402. In some embodiments, the one or more fixation members 4402 may be equally spaced circumferentially on the artificial capsule device 4400. In some embodiments, the one or more fixation members 4402 may include a stalk portion 4402A and / or a securement portion 4402B. In some embodiments, a first end of the stalk portion 4402A may be coupled to the outer surface of the artificial capsule device 4400. In some embodiments, the anchor portion 4402B may be coupled to a second end of the shaft portion 4402A.

[0342] In some embodiments, the stem 4402A may be cylindrical or any other prismatic shape. In some embodiments, the stem 4402A may include a height 4402A-1. In some embodiments, the height 4402A-1 of the stem 4402A may be about the thickness of the anterior capsule. In some embodiments, the height 4402A-1 of the stem 4402A may be greater than the thickness of the anterior capsule.

[0343] In some embodiments, the shaft 4402A can include a diameter or width that can be about 0.1 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, and / or any value between the aforementioned values.

[0344] In some embodiments, the fastener portion 4402B may be a piece of material having a circular, hemispherical, rectangular, triangular, and / or any other shaped profile, where the profile is the shape of the fastener portion 4402B when viewed from the top of the fastener portion 4402B. The top of the fastener portion 4402B may be the end of the fastener portion 4402B opposite the end of the fastener portion 4402B that is coupled to the second end of the stem portion 4402A. In some embodiments, the fastener portion 4402B may be shaped to be the tip of a mushroom and / or the shape of a curved bulb.

[0345] In some embodiments, the profile of the fastener portion 4402B can include a diameter or width, hi some embodiments, the diameter or width of the profile of the fastener portion 4402B can be greater than the diameter or width of the shaft portion 4402A. In some embodiments, the diameter or width of the profile of fastener portion 4402B can be about 0.1 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2.0 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3.0 mm and / or any value between the aforementioned values.

[0346] In some embodiments, one or more fixing members 4402 may be coupled to the artificial capsule device 4400 at a radial distance from the center of the artificial capsule device 4400. In some embodiments, the radial distance may be about 1.0 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, 2.0 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3.0 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4.0 mm, and / or any value between the aforementioned values.

[0347] In some embodiments, one or more microreximes 4400A may be formed in the anterior capsule. In some embodiments, one or more microreximes 4400A may be formed at the periphery of the anterior capsule. In some embodiments, one or more microreximes 4400A may be formed by a femtosecond laser. In some embodiments, one or more microreximes 4400A may be positioned at a radial distance from the center of the anterior capsule such that the one or more microreximes 4400A may be substantially aligned with one or more fixation members 4402. In some embodiments, the radial distance is about 1.0 mm, about 1.1 mm, about 1.2 mm, about 1.3 mm, about 1.4 mm, about 1.5 mm, about 1.6 mm, about 1.7 mm, about 1.8 mm, about 1.9 mm, about 2.0 mm, about 2.1 mm, about 2.2 mm, about 2.3 mm, about 2.4 mm, about 2.5 mm, about 2.6 mm, about 2.7 mm, about 2.8 mm, about 2.9 mm, about 3.0 mm, about 3.1 mm, about 3.2 mm, about 3.3 mm, about 3.4 mm, about 3.5 mm, about 3.6 mm, about 3.7 mm, about 3.8 mm, about 3.9 mm, about 4.0 mm, and / or any value between the aforementioned values. In some embodiments, four Microlexis 4400A may be formed in the anterior capsule. In some embodiments, 2 to 8 microrexis 4400A may be formed in the anterior capsule.

[0348] In some embodiments, the microlexis 4400A may comprise a diameter or width. In some embodiments, the diameter or width of the microlexis 4400A may be the diameter or width of the shaft portion 4204A of one or more fixation members 4402. In some embodiments, the diameter or width of the microlexis 4400A may be about 0.1 mm, about 0.2 mm, about 0.3 mm, about 0.4 mm, about 0.5 mm, about 0.6 mm, about 0.7 mm, about 0.8 mm, about 0.9 mm, about 1.0 mm, and / or any value between the aforementioned values. In some embodiments, the diameter or width of the microlexis 4400A may be smaller than the diameter or width of the profile of the fixation portion 4402B.

[0349] In some embodiments, the artificial capsule device 4400 can be inserted into the capsular bag so that one or more fixation members 4402 are positioned anterior to the rest of the prosthetic device 4400. In some embodiments, one or more fixation members 4402 can be inserted through one or more microreximes 4400A so that the fixation portions 4402B of the one or more fixation members 4402 extend into the ciliary sulcus. In some embodiments, the fixation portions 4402B can be shaped so that they are inserted through one or more microreximes 4400A and cannot be removed through the one or more microreximes 4400A. In some embodiments, the fixation portions 4402B can fix the artificial device 4400 to the anterior capsule. In some embodiments, the fixation portions 4402B can form a transcapsular bond. In some embodiments, the fixation portions 4402B can prevent the artificial device 4400 from being unfixed relative to the anterior capsule.

[0350] In some embodiments, one or more fixation members 4402 can bind or fix the artificial capsule device 4400 to the zonular complex. In some embodiments, as the ciliary muscle contracts, expands, and / or relaxes, the ciliary muscle can radially move one or more fixation members 4402. In some embodiments, radial movement of one or more fixation members 4402 can radially contract or expand the artificial capsule device 4400.

[0351] In some embodiments, contraction or expansion of the artificial capsule device 4400 in the radial direction may cause the artificial capsule device 4400 to expand or contract in the anterior / posterior direction. In some embodiments, the artificial capsule device 4400 may expand in the anterior / posterior direction when the ciliary muscle contracts. In some embodiments, the artificial device 4400 may contract in the anterior / posterior direction when the ciliary muscle relaxes.

[0352] In some embodiments, expansion and / or contraction of artificial capsule device 4400 in the anterior / posterior direction can allow artificial capsule device 4400 to act as a spring between posterior lens 4404 and / or anterior lens 4406, as shown in FIG. 44C. In some embodiments, movement of the ciliary muscle can change the distance between posterior lens 4404 and the anterior surface of artificial capsule device 4400. In some embodiments, movement of the ciliary muscle can change the distance between anterior lens 4406 and the posterior surface of artificial capsule device 4400. In some embodiments, movement of the ciliary muscle can change the distance between posterior lens 4400 and anterior lens 4406.

[0353] In some embodiments, the posterior lens 4404 may be coupled to the artificial capsule device 4400. In some embodiments, the posterior lens 4404 may be positioned posterior to the artificial capsule device 4400 within the lens capsule. In some embodiments, the anterior lens 4406 may be coupled to the artificial capsule device 4400. In some embodiments, the anterior lens 4406 may be coupled to the anterior opening of the artificial capsule device 4400, the internal cavity of the artificial capsule device 4400, and / or within the ciliary sulcus.

[0354] In some embodiments, the posterior lens 4404 and / or the anterior lens 4406 may be a minus power lens (i.e., a plano-concave lens, a biconcave lens, or a concave-plano lens). In some embodiments, the posterior lens 4404 and / or the anterior lens 4406 may be a plus power lens (i.e., a plano-convex lens, a biconvex lens, or a convex-plano lens). In some embodiments, the posterior lens 4404 may be a minus power lens and the anterior lens 4406 may be a plus power lens.

[0355] In some embodiments, the posterior lens 4404 and / or the anterior lens 4406 can include a light adjustable power. The light adjustable power can adjust the refractive state of the eye after the artificial capsule device 4400, the posterior lens 4404, and / or the anterior lens 4406 are inserted into the eye. In some embodiments, the light adjustable power can include one or more sensors that detect the amount of light and / or the contraction or relaxation of the ciliary muscles. In some embodiments, the light adjustable power can adjust or change the power of the posterior lens 4404 and / or the anterior lens 4406 electromechanically via an algorithm (e.g., change the lens curvature, change the lens thickness, change the lens refractive index).

[0356] (Additional embodiment) In the foregoing specification, the invention has been described with reference to specific embodiments thereof. It will, however, be apparent that various modifications and changes may be made thereto without departing from the broader spirit and scope of the invention. The specification and drawings are, therefore, to be regarded in an illustrative rather than a restrictive sense.

[0357] Indeed, while the present invention has been disclosed in the context of certain embodiments and examples, those skilled in the art will recognize that the present invention extends beyond the specifically disclosed embodiments to other alternative embodiments and / or uses of the invention, as well as obvious modifications and equivalents thereof. Moreover, while several variations of the embodiments of the present invention have been shown and described in detail, other modifications that are within the scope of the present invention will be readily apparent to those skilled in the art based on this disclosure. It is also contemplated that various combinations or subcombinations of specific features and aspects of the embodiments may be made and still fall within the scope of the present invention. It should be understood that various features and aspects of the disclosed embodiments can be combined with or substituted for one another to form varying aspects of the disclosed embodiments of the present invention. The methods disclosed herein need not be performed in the order described. Therefore, it is not intended that the scope of the invention disclosed herein be limited by the specific embodiments described above.

[0358] It will be understood that the systems and methods of the present disclosure each have several innovative aspects, no single one of which is solely responsible for or necessary to the desirable properties disclosed herein. The various features and steps described above can be used independently of one another or can be combined in several ways. All possible combinations and subcombinations are intended to fall within the scope of the present disclosure.

[0359] Certain features that are described in this specification in the context of separate embodiments can also be implemented in combination in a single embodiment. Conversely, various features that are described in the context of a single embodiment can also be implemented in multiple embodiments separately or in any suitable subcombination. Furthermore, while features may be described above as working in a particular combination and may even be initially claimed as such, one or more features from the claimed combination may in some cases be excluded from the combination, and the claimed combination may be directed to a subcombination or a variation of the subcombination. No single feature or group of features is necessary or essential to every individual embodiment.

[0360] Additionally, as used herein, conditional expressions such as "can," "may," "might," "could," "for example," and the like, among others, are understood to generally convey that certain embodiments include certain features, elements, and / or steps, and that other embodiments do not include certain features, elements, and / or steps, unless specifically stated otherwise or understood otherwise within the context in which they are used. Thus, such conditional expressions generally do not imply that features, elements, and / or steps are in any way required by one or more embodiments, or that one or more embodiments necessarily include logic for determining, with or without authorial input or direction, whether these features, elements, and / or steps are included or performed in any particular embodiment. Terms such as "comprise," "comprising," and "having" are synonymous and are used in an inclusive, open-ended manner and do not exclude additional elements, features, actions, operations, etc. Furthermore, the term "or" is used in an inclusive (rather than exclusive) sense; for example, when used to connect a list of elements, the term "or" may refer to one, some, or all of the elements in the list. Furthermore, the articles "a," "an," and "the," as used in this application and the appended claims, shall be construed to mean "one or more" or "at least one," unless otherwise specified. Similarly, while operations may be depicted in the figures in a particular order, it should be recognized that such operations need not be performed in the particular order shown, nor in sequential order, nor that all of the depicted operations need be performed to achieve desirable results. Furthermore, the figures may generally depict one or more exemplary steps in the form of a flowchart. However, other operations not shown may be incorporated into the illustrative methods and steps generally depicted. For example, one or more additional operations may be performed before, after, simultaneously with, or between any of the depicted operations. Furthermore, operations may be rearranged or reordered in other embodiments.In certain situations, multitasking and parallel processing may be advantageous. Furthermore, the separation of various system components in the above-described embodiments should not be understood as requiring such separation in all embodiments, and it should be understood that the described program components and systems may generally be integrated together in a single software product or packaged in multiple software products. Furthermore, other embodiments are within the scope of the following claims. In some cases, the actions recited in the claims can be performed in a different order and still achieve desirable results.

[0361] Furthermore, the methods and devices described herein are susceptible to various modifications and alternative forms, specific examples of which are shown in the drawings and described in detail herein. However, it should be understood that the present invention is not limited to the particular forms or methods disclosed; rather, the present invention covers all modifications, equivalents, and alternatives falling within the spirit and scope of the various described embodiments and the appended claims. Furthermore, the disclosure herein of particular features, aspects, methods, properties, characteristics, attributes, elements, etc., associated with one embodiment or embodiment can be used in all other embodiments or embodiments described herein. The methods disclosed herein need not be performed in the order described. The methods disclosed herein may include specific actions performed by a practitioner, but the methods may also include, explicitly or implicitly, any third-party direction of those actions. Furthermore, ranges disclosed herein encompass all overlaps, subranges, and combinations thereof. Expressions such as "up to," "at least," "greater than," "less than," "between," and the like, include the recited values. Numerical values ​​preceded by terms such as "about" or "approximately" are inclusive of the stated value and should be interpreted in accordance with the context (e.g., as precisely as reasonably possible under the circumstances, e.g., ±5%, ±10%, ±15%, etc.). For example, "about 3.5 mm" includes "3.5 mm". Phrases preceded by terms such as "substantially" are inclusive of the stated value and should be interpreted in accordance with the context (e.g., as precisely as reasonably possible under the circumstances). For example, "substantially constant" includes "constant". Unless otherwise noted, all measurements are conducted under standard conditions, including temperature and pressure.

[0362] As used herein, a phrase referring to "at least one" of a list of items refers to any combination of those items, including singular ones. As an example, "at least one of A, B, or C" is intended to encompass A, B, C, A and B, A and C, B and C, and A, B, and C. Connecting terms such as "at least one of X, Y, and Z" are understood in context as generally used to convey that an item, term, etc. may be at least one of X, Y, or Z, unless otherwise noted. Thus, such connecting terms do not generally imply that at least one of X, at least one of Y, and at least one of Z must each be present in a particular embodiment. Headings, if any, provided herein are for convenience only and do not necessarily affect the scope or meaning of the devices and methods disclosed herein.

[0363] Thus, the scope of the claims is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the present disclosure and the principles and novel features disclosed herein.

Claims

1. An artificial capsule device configured to be inserted into a lens capsule of an eye, the artificial capsule device including a housing structure and a drug delivery device; the housing structure includes a front portion, a rear portion, an internal cavity, and a groove; The front portion is A forward circular opening; a forward rim surrounding the forward circular opening and defining a perimeter of the forward circular opening; a forward sidewall connected to the forward rim and extending laterally outward and rearward from the forward rim to a center plane of the housing structure; The rear portion is A rear circular opening; a rear rim surrounding the rear circular opening and defining a perimeter of the rear circular opening; a rear sidewall connected to the rear rim and extending laterally outward and forward from the rear rim to the longitudinal center plane of the housing structure; the internal cavity is defined between the front circular opening and the rear circular opening and is configured to accommodate the medication delivery device; the groove is formed by one or more ribs formed along a periphery of the internal cavity at the longitudinal center plane of the housing structure, each rib of the one or more ribs including upper and lower surfaces formed with a rib angle, the groove being configured to hold the medication delivery device in place within the internal cavity of the housing structure; An artificial capsule device characterized in that the drug supply device has a ring or arc configuration and the drug supply device is held in the predetermined position within the groove formed by the one or more ribs within the internal cavity of the housing structure.

2. The artificial capsule device of claim 1, wherein the drug delivery device comprises a circle, square, rectangle, oval, triangle, rounded triangle, pentagon, trapezoid, ellipse, semicircle, hexagon, octagon, ring, diamond, or star shape when viewed in profile.

3. The artificial capsule device of claim 1, wherein the drug delivery device comprises a length and a width, and the ratio of the length to the width is from about 2:1 to about 200:

1.

4. The artificial capsule device described in claim 3, wherein the length is between 1 mm and 50 mm.

5. The artificial capsule device described in claim 1, wherein the drug delivery device contacts the inner surface or inner side wall of the housing structure.

6. The artificial capsule device of claim 1, wherein the drug delivery device is configured to bend or curve from a straight configuration to the ring configuration or the arc configuration.

7. The artificial capsule device of claim 1, wherein the drug delivery device comprises an outer diameter of about 3 mm to about 12 mm.

8. The artificial capsule device described in claim 1, wherein the length of the drug delivery device is substantially equal to the outer circumference of the internal cavity of the housing structure.

9. The artificial capsule device of claim 1, wherein the length of the drug supply device is longer than the outer periphery of the internal cavity of the housing structure so that at least a portion of the drug supply device overlaps when the drug supply device is held in the internal cavity.

10. The artificial capsule device described in claim 1, wherein the length of the drug delivery device is shorter than the outer circumference of the internal cavity of the housing structure.

11. further comprising a second drug delivery device having an arcuate configuration; The artificial capsule device described in claim 10, wherein the second drug supply device is held in the predetermined position within the groove formed by the one or more ribs within the internal cavity of the housing structure.

12. The artificial capsule device described in claim 11, wherein the second drug supply device has a second length, and the sum of the length of the drug supply device and the second length of the second drug supply device is approximately equal to the outer circumference of the internal cavity of the housing structure.

13. The artificial capsule device described in claim 12, wherein the drug supply device and the second drug supply device collectively form substantially a ring shape within the groove of the housing structure.

14. The artificial capsule device described in claim 1, wherein the drug delivery device comprises a bioerodible material.

15. The artificial capsule device of claim 14, wherein the bioerodible material comprises collagen, alginate, poly(lactic-co-glycolic acid) (PLGA), polyanhydride, polycaprolactone, poly(trimethylene carbonate), or polyphosphazene.

16. The artificial capsule device described in claim 14, wherein the bioerodible material is impregnated or infused with one or more drugs.

17. The artificial capsule device described in claim 16, wherein the one or more drugs are anti-inflammatory agents (NSAIDs, steroids), anti-fibrotic agents (mitomycin), immunomodulatory agents (cyclosporine, tacrolimus, methotrexate), antiviral agents (ganciclovir, valacyclovir, acyclovir), antibiotics, antifungal agents (voriconazole, natamycin, amphotericin B), or anti-VEGF agents (Avastin, Lucentis, Eylea).

18. The artificial capsule device of claim 1, wherein the drug delivery device comprises silicone, vulcanized silicone, and / or a silicone polymer.

19. The artificial capsule device of claim 1, wherein the drug delivery device includes one or more holes, eyelets, slits, and / or openings.

20. The artificial capsule device described in claim 19, wherein the one or more holes, eyelets, slits, and / or openings are configured to allow the drug delivery device to be positioned within the internal cavity of the housing structure by an injector.

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