Antibacterial toothpaste

Abstract

An antibacterial toothpaste is provided that includes an electrically charged antibacterial toothpaste abrasive. The present invention includes a ferroelectric ceramic, the ferroelectric ceramic being potassium sodium niobate K 0.5 Na 0.5 NbO3, barium titanate BaTiO3, lithium niobate LiNbO3, barium strontium titanate Ba x Sr 1-x At least one or more compounds or compositions selected from TiO3,

Description

[Technical Field]

[0001] This application claims priority to an application filed on December 16, 2022, bearing application number CN202211618989.3 and entitled "Antibacterial Toothpaste," the entire contents of which are incorporated herein by reference.

[0002] This application relates to the technical field of toothpastes, and in particular to antibacterial toothpastes. [Background technology]

[0003] Abrasives are the most common ingredient in toothpaste and are primarily responsible for cleaning teeth. Currently, toothpaste abrasives are often composed of calcium carbonate, silicon dioxide, aluminum hydroxide, calcium hydrogen phosphate, calcium pyrophosphate, etc. However, these abrasives lack antibacterial properties and are unable to simultaneously inhibit plaque adhesion and prevent periodontitis and caries during toothbrushing. With the rise in people's living standards and health awareness, toothpastes with excellent antibacterial properties are in high demand. Currently, antibacterial toothpaste products are primarily designed to achieve their antibacterial properties by adding bacteriostatic ingredients, but these methods have drawbacks, such as poor long-term biocompatibility, safety, and antibacterial stability. Summary of the Invention [Problem to be solved by the invention]

[0004] The purpose of this application is to provide an antibacterial toothpaste that achieves the dual effects of teeth cleaning and antibacterial. The specific technical solution is as follows: [Means for solving the problem]

[0005] The present application provides an antibacterial toothpaste comprising an electrically charged antibacterial toothpaste abrasive, the electrically charged antibacterial toothpaste abrasive comprising a ferroelectric ceramic, the ferroelectric ceramic being potassium sodium niobate K 0.5 Na 0.5NbO3, barium titanate BaTiO3, lithium niobate LiNbO3, barium strontium titanate Ba x Sr 1-x At least one or more compounds or compositions selected from TiO3, <x<1である。 [Effects of the Invention]

[0006] The antibacterial toothpaste provided in the present application employs an electrostatically charged antibacterial toothpaste abrasive containing the above-mentioned ferroelectric ceramic. Due to the spontaneous polarization properties of the ferroelectric ceramic, it can maintain good electrical stability. The remanent polarization effect of the ferroelectric ceramic inhibits bacteria and plaque on the tooth surface, thereby not only achieving a tooth cleaning effect during brushing, but also exhibiting an antibacterial effect, thereby achieving functions such as inhibiting bacteria, inhibiting plaque, and preventing and alleviating periodontal inflammation or caries. Furthermore, the employment of an electrostatically charged antibacterial toothpaste abrasive containing the above-mentioned ferroelectric ceramic can improve the long-term compatibility, safety, and antibacterial stability of the antibacterial toothpaste. Of course, it is not necessary for all of the above advantages to be achieved simultaneously in practicing any of the products or methods herein. [Brief explanation of the drawings]

[0007] [Figure 1] 2 is an electron microscope photograph of ferroelectric ceramics in Examples 1 to 5. [Figure 2] 1 shows X-ray diffraction patterns of ferroelectric ceramics in Examples 1 to 5. [Figure 3] 1 shows the results of the antibacterial rate of the antibacterial toothpastes of Examples 1 and 5 under the temperature change conditions of the hot and cold cycle. [Figure 4] 1 shows the results of the antibacterial rate of the antibacterial toothpaste of Example 3 under temperature change conditions and constant temperature conditions. [Figure 5] 1 shows the results of plaque removal rates of toothpastes of Examples 3, 6, and Comparative Examples 1 and 2. [Figure 6]Figure 1 shows the antibacterial effect of BaTiO3 fibers with different dosages under temperature change and constant temperature conditions. [Figure 7] This is a comparison of the bacterial growth inhibitory ability of an electroactive toothpaste (containing Ba0.7Sr0.3TiO3) and a commercially available fluoride-containing toothpaste (0.1% fluoride content). [Figure 8] The results show a comparison of the cleaning effects of an electroactive toothpaste (containing Ba0.7Sr0.3TiO3) and a commercially available fluoride-containing toothpaste (0.1% fluoride content). [Figure 9] This is a comparison of the bacterial inhibition and bactericidal effects of an electroactive toothpaste (containing Ba0.7Sr0.3TiO3) and a commercially available fluoride-containing toothpaste (fluoride content 0.1%). DETAILED DESCRIPTION OF THE INVENTION

[0008] In order to more clearly explain the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings used in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present application, and those skilled in the art can further derive other embodiments based on these drawings. Hereinafter, the technical solutions in the embodiments of the present application will be clearly and completely described with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only some of the embodiments of the present application, not all of the embodiments, and all other embodiments that those skilled in the art can obtain based on the embodiments of the present application fall within the scope of protection of the present application.

[0009] The present application provides an antibacterial toothpaste comprising an electrically charged antibacterial toothpaste abrasive, the electrically charged antibacterial toothpaste abrasive comprising a ferroelectric ceramic, the ferroelectric ceramic being potassium sodium niobate K 0.5 Na 0.5 NbO3, barium titanate BaTiO3, lithium niobate LiNbO3, barium strontium titanate Ba x Sr 1-x At least one or more compounds or compositions selected from TiO3, <x<1である。

[0010] The antibacterial toothpaste provided in the present application employs an electrostatic antibacterial toothpaste abrasive containing the above-mentioned ferroelectric ceramic, and due to the spontaneously electric polarization properties of the above-mentioned ferroelectric ceramic, it can maintain good electrical stability. The remanent polarization effect of the above-mentioned ferroelectric ceramic inhibits bacteria and plaque on the tooth surface, thereby not only achieving a teeth cleaning effect during brushing, but also exerting an antibacterial effect due to the sustained and stable electrostatic properties of the above-mentioned electrostatic antibacterial toothpaste abrasive, and maintaining good antibacterial performance, thereby achieving functions such as inhibiting bacterial activity on the tooth surface, inhibiting plaque adhesion, and preventing and alleviating periodontal inflammation or caries.

[0011] In some embodiments of the present application, the ferroelectric ceramic is previously subjected to corona polarization treatment, and the parameters of the corona polarization treatment include a polarization voltage of 1 to 30 kV, a polarization distance of 1 to 50 mm, and a polarization time of 1 to 60 min.

[0012] In some embodiments of the present application, the ferroelectric ceramic includes ferroelectric ceramic particles or ferroelectric ceramic fibers. In some embodiments of the present application, the ferroelectric ceramic particles have a particle size of 1 to 3 μm, and the ferroelectric ceramic fibers have an aspect ratio of 1 to 6, a length of 1 to 6 μm, and a diameter of 200 to 400 nm.

[0013] In the present application, by using ferroelectric ceramic particles with a particle size of 1 to 3 μm or ferroelectric ceramic fibers with an aspect ratio of 1 to 6, the structure of the abrasive in the electrostatic antibacterial toothpaste can be made uniform, the electrical properties can be stabilized, and the degree of tooth wear during tooth cleaning can be reduced.In the present application, by using ferroelectric ceramic particles with a particle size of 1 to 3 μm, the particles are fine and are unlikely to cause a foreign body sensation, and the aggregation and reverse coarsening phenomena caused by particles that are too small (for example, less than 1 μm) can be avoided.

[0014] In some embodiments of the present application, the charged antimicrobial toothpaste abrasive has a Mohs hardness of 2-4. In some embodiments of the present application, the antibacterial toothpaste comprises 10-50 wt % of the charged antibacterial toothpaste abrasive, based on the weight percentage of the antibacterial toothpaste, and preferably the antibacterial toothpaste comprises 20-40 wt % of the charged antibacterial toothpaste abrasive.

[0015] In this application, when the weight percentage of the charged antibacterial toothpaste abrasive in the antibacterial toothpaste is 10-50 wt%, the antibacterial performance of the antibacterial toothpaste will be good, with the antibacterial rate of the antibacterial toothpaste being in the range of 15-99.99%; when the weight percentage of the charged antibacterial toothpaste abrasive in the antibacterial toothpaste is 20-40 wt%, the antibacterial performance of the antibacterial toothpaste will be even better, with the antibacterial rate of the antibacterial toothpaste being in the range of 30-99.99%.

[0016] In some embodiments of the present application, the antibacterial toothpaste also contains a regular toothpaste abrasive, and the regular toothpaste abrasive is at least one selected from calcium carbonate, silicon dioxide, aluminum hydroxide, calcium hydrogen phosphate, and calcium pyrophosphate. Based on the weight percentage of the antibacterial toothpaste, the total weight of the charged antibacterial toothpaste abrasive and the regular toothpaste abrasive is 10 to 50 wt%, and the weight ratio of the charged antibacterial toothpaste abrasive to the regular toothpaste abrasive is 1:(0 to 1). Preferably, the total weight of the charged antibacterial toothpaste abrasive and the regular toothpaste abrasive is 20 to 40 wt%.

[0017] In some embodiments of the present application, when the weight percentage of the charged antibacterial toothpaste abrasive in the antibacterial toothpaste is 20-40 wt % and no conventional toothpaste abrasive is included, the antibacterial rate of the antibacterial toothpaste is in the range of 40-99.99%. In some embodiments of the present application, the antibacterial rate of the antibacterial toothpaste is 15 to 99.99%, preferably, the antibacterial rate of the antibacterial toothpaste is 30 to 99.99%, and more preferably, the antibacterial rate of the antibacterial toothpaste is 40 to 99.99%.

[0018] The present application is not particularly limited to a method for producing the ferroelectric ceramic particles as long as the object of the present application can be achieved. For example, the present application may include a method for producing the ferroelectric ceramic particles, (1) weighing, mixing and grinding ferroelectric ceramic raw materials to obtain a mixed material; (2) firing the mixed material at a high temperature to generate the ferroelectric ceramic by a solid-state reaction, and polishing the ferroelectric ceramic powder; (3) subjecting the ferroelectric ceramic powder to corona polarization treatment to obtain the ferroelectric ceramic particles, wherein the corona polarization treatment parameters include a polarization voltage of 1-30 kV, a polarization distance of 1-50 mm, and a polarization time of 1-60 min; This includes the step:

[0019] Wherein, in step (1), the ferroelectric ceramic raw material may be an oxide, carbonate, nitrate, etc. of the corresponding element, and the present application is not particularly limited thereto as long as the object of the present application can be achieved. Wherein, before weighing the ferroelectric ceramic raw material, the ferroelectric ceramic raw material is pretreated to remove impurities and moisture. The present application is not particularly limited to the method of the mixing and grinding, and may be, for example, dry grinding or wet grinding, or may be an agitation ball mill or jet grinding, as long as the object of the present application can be achieved. In step (2), the resulting ferroelectric ceramic is densified by firing at high temperature to cause a solid-state reaction, and then polished to obtain a ferroelectric ceramic powder with a uniform composition and an appropriate particle size. In step (3), after the corona polarization treatment, the surfaces of the ferroelectric ceramic particles have a certain polarization charge and have a sustained and stable charging ability.

[0020] The method for producing ferroelectric ceramic particles described herein is simple, efficient, low-cost, highly controllable, and amenable to industrialized production. The present application is not particularly limited to a method for producing the above-mentioned ferroelectric ceramic fiber, as long as the object of the present application can be achieved. For example, the ferroelectric ceramic fiber described in the present application can be produced using an electrospinning method.

[0021] The antibacterial toothpaste of the present application uses the charged antibacterial toothpaste abrasive of the present application, and other components may include humectants, adhesives, foaming agents, preservatives, fragrances, sweeteners, water, etc., and the present application is not particularly limited as long as the object of the present application can be achieved.

[0022] The present application is not particularly limited to a method for producing the antibacterial toothpaste, as long as the object of the present application can be achieved.

[0023] Hereinafter, the embodiments of the present invention will be described more specifically with reference to examples and comparative examples. Test method and equipment: Particle size test: The particle size of ferroelectric ceramic particles is measured under an electron microscope, and the particle size distribution is statistically analyzed. Hardness test: Select a sharp position on the charged antibacterial toothpaste abrasive sample to be tested, and perform an indentation test on the flat surface of a flat mineral hardness tester with known hardness, in order from low to high hardness. Observe whether there are facets on the flat surface of the hardness tester. To avoid incorrect judgment, lightly wipe the flat surface so that the powder of the measurement sample remains on the hardness tester. If there are scratches on the flat surface of the hardness tester, the hardness of the sample will be greater than that of the hardness tester. Test with higher hardness testers until it is between two hardness levels or corresponds to a specific hardness tester, and determine the Mohs hardness of the charged antibacterial toothpaste abrasive to be tested.

[0024] Cleaning performance test: (1) Bovine teeth were selected as stain carriers and subjected to a preliminary sandblasting cleaning process. They were then immersed in albumin solution, a tea / coffee mixture, and an iron citrate solution for 30 minutes each. This process was repeated until the stains firmly adhered to the tooth surface, and the tooth was then prepared for use. The stained bovine tooth was then placed in the sample slot of a toothbrush, and the stained surface was aligned with the sample slot. The brush head and arm were adjusted to match the stained surface. A toothpaste dispersion was poured into the sample slot, and a simulated toothbrushing test was performed under the specified conditions with a specified load. The stain removal ability was evaluated based on changes in the photographs. (2) The bovine tooth and oral plaque bacterial solution were co-cultured in BHI liquid medium (Brain Heart Infusion medium) for 12 hours. The medium was removed with a pipette and gently washed once with sterile saline to remove floating bacteria. The bovine tooth was then removed and placed in the sample slot of a toothbrush, and the stained surface was aligned with the sample slot. The brush head and arm were adjusted to match the stained surface. The toothpaste dispersion was poured into the sample slot, and a simulated toothbrushing test was performed under the specified conditions with a specified load. An appropriate amount of the staining solution was dropped onto the surface of a bovine tooth, and the tooth was incubated at room temperature in a dark room for 15 minutes. The tooth was then carefully washed with phosphate-buffered saline (PBS) to remove excess dye. Images were then observed using a laser confocal microscope (CLSM). The green fluorescence intensity was measured and the plaque removal rate was calculated by (1 - green fluorescence intensity of the toothpaste group / green fluorescence intensity of the control group) x 100%. Antibacterial performance test: Take toothpaste and add 300 μL (10 4 A co-culture experiment was conducted with 1000 CFU / mL) of Streptococcus mutans under 25 heat-cold cycles (temperature changes from 20 to 45°C) or constant temperature conditions (37°C), and the number of bacteria in the bacterial solution was counted. The bacterial activity rate of the toothpaste was calculated using the formula: bacterial activity rate = (number of bacteria before culture - number of bacteria after culture) / number of bacteria before culture x 100%, and the antibacterial rate was calculated using the formula: antibacterial rate = 1 - bacterial activity rate.

[0025] Example 1 <Production of electrostatic antibacterial toothpaste abrasives> BaTiO3 particles were taken and subjected to corona polarization treatment to obtain polarized BaTiO3 particles, which were used as charged antibacterial toothpaste abrasives. The corona polarization treatment parameters included a polarization voltage of 20 kV, a polarization distance of 25 mm, and a polarization time of 30 min.

[0026] <Toothpaste manufacturing> Based on the weight percentage of the toothpaste, the charged antibacterial toothpaste contained the following: abrasive: BaTiO3 particles 20 wt%, humectant: sorbitol 61 wt%, adhesive: sodium hydroxymethylcellulose 1 wt%, foaming agent: sodium lauryl sulfate 2 wt%, preservative: parabens 3 wt%, flavoring: essence 1 wt%, sweetener: saccharin 0.3%, and the remainder was deionized water. The above ingredients were weighed out by weight percentage, the humectant was placed in a paste making machine, the preservative, flavor and sweetener were dissolved in water and stirred in a liquid tank until uniformly mixed, then added to the paste making machine and stirred for 10 minutes until uniformly mixed, the toothpaste abrasive, adhesive and foaming agent were mixed uniformly, added to the paste making machine and stirred for 15 minutes until uniformly mixed, and then deaerated to obtain toothpaste.

[0027] Example 2 <Production of electrostatic antibacterial toothpaste abrasives> Ba 0.8 Sr 0.2 After taking TiO3 particles and undergoing corona polarization treatment, the Ba 0.8 Sr 0.2 The TiO3 particles were obtained and used as the charged antibacterial toothpaste abrasive, and the corona polarization treatment parameters included polarization voltage 5 kV, polarization distance 3 mm, and polarization time 50 min.

[0028] <Toothpaste manufacturing> Based on the weight percentage of toothpaste, electrostatic antibacterial toothpaste abrasive: Ba 0.8 Sr 0.2 It contained 40 wt% TiO3 particles, 50 wt% sorbitol as a moisturizer, 1 wt% sodium hydroxymethylcellulose as an adhesive, 0.5 wt% sodium lauryl sulfate as a foaming agent, 2 wt% parabens as a preservative, 0.8 wt% essence as a fragrance, and 0.3% saccharin as a sweetener, with the remainder being deionized water. The manufacturing steps of the toothpaste were the same as in Example 1.

[0029] Example 3 <Production of electrostatic antibacterial toothpaste abrasives> Ba 0.7 Sr 0.3 After taking TiO3 particles and undergoing corona polarization treatment, the Ba 0.7 Sr 0.3 The TiO3 particles were obtained and used as the charged antibacterial toothpaste abrasive, and the corona polarization treatment parameters included polarization voltage 25 kV, polarization distance 35 mm, and polarization time 30 min.

[0030] <Toothpaste manufacturing> Antibacterial toothpaste with abrasives 0.7 Sr 0.3 The same as Example 2 except that TiO3 particles were substituted.

[0031] Example 4 <Production of electrostatic antibacterial toothpaste abrasives> Ba 0.6 Sr 0.4 After taking TiO3 particles and undergoing corona polarization treatment, the Ba 0.6 Sr 0.4 The TiO3 particles were obtained and used as the charged antibacterial toothpaste abrasive, and the corona polarization treatment parameters included polarization voltage 30 kV, polarization distance 18 mm, and polarization time 5 min.

[0032] <Toothpaste manufacturing> Antibacterial toothpaste with abrasives 0.6 Sr 0.4 The same as Example 2 except that TiO3 particles were substituted.

[0033] Example 5 <Production of electrostatic antibacterial toothpaste abrasives> (1) 9 mL of glacial acetic acid was taken and mixed with 1.340 g of acetylacetone, and then stirred for 5 minutes while sealed with plastic wrap. 1.703 g of barium acetate was added and stirred for 1 hour until completely dissolved. 2.266 g of tetrabutyl titanate was added and stirred for 15 minutes. 0.45 g of polyvinylpyrrolidone was added and stirred for 2 to 3 hours until completely dissolved, yielding an electrospinning solution. (2) The electrospinning solution was taken and subjected to electrospinning, then dried at 70°C overnight for 12 hours, placed in a muffle furnace and heated to 500°C at a heating rate of 5°C / min, sintered for 2 hours, then heated to 750°C and sintered for 2 hours, and then naturally cooled to obtain BaTiO3 fibers. The electrospinning parameters included voltage: positive voltage 7.5kV, negative voltage 7.5kV, injection speed: 0.035mm / min, syringe model 22g, needle-to-roller distance 15cm, and roller rotation speed 800rpm. The obtained BaTiO3 fibers were taken and subjected to corona polarization treatment to obtain polarized BaTiO3 fibers, which were used as the charged antibacterial toothpaste abrasive. The corona polarization treatment parameters were the same as those in Example 1.

[0034] <Toothpaste manufacturing> The electrostatically charged antibacterial toothpaste was the same as in Example 1, except that the type of abrasive was replaced with BaTiO3 fibers.

[0035] Example 6 <Production of electrostatic antibacterial toothpaste abrasives> Ba 0.7 Sr 0.3 After taking TiO3 particles and undergoing corona polarization treatment, the Ba 0.7 Sr 0.3 The TiO3 particles were obtained and used as the charged antibacterial toothpaste abrasive, and the corona polarization treatment parameters included polarization voltage 25 kV, polarization distance 35 mm, and polarization time 30 min. <Toothpaste manufacturing> Based on the weight percentage of toothpaste, electrostatic antibacterial toothpaste abrasive: Ba 0.7 Sr 0.3It contained 20 wt% TiO3 particles, 20 wt% SiO2 (normal toothpaste abrasive), 50 wt% sorbitol (humectant), 1 wt% sodium hydroxymethylcellulose (adhesive), 0.5 wt% sodium lauryl sulfate (foaming agent), 2 wt% parabens (preservative), 0.8 wt% essence (flavoring), 0.3% saccharin (sweetener), and the remainder was deionized water. The manufacturing steps of the toothpaste were the same as in Example 1.

[0036] Example 7 <Production of electrostatic antibacterial toothpaste abrasives> Ba 0.7 Sr 0.3 After taking TiO3 particles and undergoing corona polarization treatment, the Ba 0.7 Sr 0.3 The TiO3 particles were obtained and used as the charged antibacterial toothpaste abrasive, and the corona polarization treatment parameters were the same as in Example 3.

[0037] <Toothpaste manufacturing> Based on the weight percentage of toothpaste, electrostatic antibacterial toothpaste abrasive: Ba 0.7 Sr 0.3 It contained 10 wt% TiO3 particles, 65 wt% sorbitol as a moisturizer, 1 wt% sodium hydroxymethylcellulose as an adhesive, 2 wt% sodium lauryl sulfate as a foaming agent, 3 wt% parabens as a preservative, 1 wt% essence as a fragrance, and 0.3% saccharin as a sweetener, with the remainder being deionized water. The manufacturing steps of the toothpaste were the same as in Example 1.

[0038] Comparative Example 1 <Toothpaste manufacturing> The same as Example 1 was performed except that the type of toothpaste abrasive was replaced with SiO2.

[0039] Comparative Example 2 <Toothpaste manufacturing> The same as Example 1, except that the toothpaste abrasive was replaced with CaCO3. When a hardness test was carried out on each of the charged antibacterial toothpaste abrasives after polarization in Examples 1 to 4, the Mohs hardness was 3 in all cases. The performance parameters of the toothpastes prepared in each of the Examples and Comparative Examples are shown in Table 1.

[0040] [Table 1]

[0041] Electron microscope photographs of the ferroelectric ceramics of Examples 1 to 5 are shown in FIG. 1, and X-ray diffraction patterns of the ferroelectric ceramics of Examples 1 to 5 are shown in FIG. 2, which show that the crystals of the ferroelectric ceramic particles of the present invention have a tetragonal phase structure, are ferroelectric, and are capable of spontaneous polarization.

[0042] The results of the antibacterial rates of the antibacterial toothpastes of Examples 1 and 5 under temperature change conditions of a hot-cold cycle are shown in Figure 3, the results of the antibacterial rates of the antibacterial toothpaste of Example 3 under temperature change conditions (ΔT) and constant temperature conditions (T0) are shown in Figure 4, and the results of the plaque removal rates of the toothpastes of Examples 3, 6, and Comparative Examples 1 and 2 are shown in Figure 5.

[0043] 3, 4, and Table 1, the antibacterial performance test showed that the blank group (without toothpaste) had a high bacterial count in the bacterial solution, while the antibacterial toothpastes containing the present invention's charged antibacterial toothpaste abrasives were able to significantly improve the antibacterial rate (****P<0.0001, compared to the blank group), demonstrating excellent antibacterial performance. The results of Examples 3 and 6 in Table 1 also show that the present invention's charged antibacterial toothpaste abrasives can be used in combination with conventional toothpaste abrasives, and the resulting antibacterial toothpastes still have excellent antibacterial performance.

[0044] According to Table 1 and FIG. 5, the cleaning rate of the antibacterial toothpaste of the present invention is equivalent to that of the toothpastes of Comparative Examples 1 and 2 (statistical result P=0.127>0.05, no statistical difference between the groups).

[0045] From the above, it can be seen that the antibacterial toothpaste of the present invention has excellent dual effects of antibacterial and tooth cleaning.

[0046] In this application, the BaTiO3 fibers after polarization in Example 5 were taken in doses of 0 mg (blank control), 5 mg, 10 mg, 20 mg, 30 mg, and 50 mg, and the antibacterial performance of the ferroelectric ceramics was tested under constant temperature conditions (T0) and under temperature change conditions (ΔT) of a thermal cycle (10 0 ) and then dilute each with PBS buffer for 10 min. 1 , 10 2 , 10 3 , 10 4 The antibacterial effect of the BaTiO3 fiber obtained by diluting it 1:1 is shown in Figure 6. As can be seen from Figure 6, the antibacterial effect of the BaTiO3 fiber under both temperature change conditions and constant temperature conditions shows a positive correlation with the dosage, and the antibacterial effect tends to increase as the dosage of the BaTiO3 fiber increases.

[0047] This application further compares the bacterial growth inhibitory ability of an electroactive toothpaste (containing BaTiO3 in Example 3) with a commercially available fluoride-containing toothpaste (0.1% fluoride content), specifically referring to Figure 7. In quantitative microbial analysis, the OD value is a commonly used method for reflecting the concentration or number of microorganisms. A mixed carious bacterial flora was co-cultured with an electroactive toothpaste (containing BST) and a commercially available fluoride-containing toothpaste (0.1% fluoride content), and the OD values ​​of the bacterial suspensions were measured at a wavelength of 630 nm at 0, 3, 6, 9, and 12 hours, respectively. A higher OD value indicates a higher total bacterial count.

[0048] The present application also provides an electroactive toothpaste (Ba in Example 3) 0.7 Sr 0.3 The cleaning efficacy of a commercially available fluoride-containing toothpaste (0.1% fluoride content) and a caries-containing mixed bacterial flora was compared. Specifically, referring to Figure 8, the caries-containing mixed bacterial flora was co-cultured with bovine teeth for 24 hours to allow the bacterial flora to settle on the surface of the bovine teeth. Then, the electrically activated toothpaste (Ba 0.7 Sr 0.3Using (containing TiO3) and a commercially available fluorine-containing toothpaste (fluorine content 0.1%) respectively, bovine teeth were cleaned by the method of brushing teeth in the mouth. After cleaning, a dead / live bacteria staining solution was dropped and incubated in the dark for 15 minutes. Then, the fluorescence expression amount of dead / live bacteria was detected by a laser confocal microscope, and the cleaning rate = (red fluorescence + green fluorescence) / blank control group * 100% (red fluorescence represents dead bacteria, and green fluorescence represents live bacteria).

[0049] This application also compares the bacteriostatic and bactericidal effects of electroactive toothpaste (Ba in Example 3 0.7 Sr 0.3 containing TiO3) and a commercially available fluorine-containing toothpaste (fluorine content 0.1%). Specifically, referring to Figure 9, a cariogenic mixed flora was co-cultured with electroactive toothpaste (containing BST) and a commercially available fluorine-containing toothpaste (fluorine content 0.1%) for 24 hours respectively. Then, the bacterial suspension was aspirated, centrifuged to precipitate, a dead / live bacteria staining solution was dropped and incubated in the dark for 15 minutes, centrifuged to precipitate, washed with PBS, and the fluorescence expression amount of dead / live bacteria was detected by a laser confocal microscope. The bacteriostatic rate = red fluorescence color / (red fluorescence + green fluorescence) * 100% (red fluorescence represents dead bacteria, and green fluorescence represents live bacteria).

[0050] In summary, the antibacterial toothpaste provided in this application contains a charged antibacterial toothpaste abrasive, and the above-mentioned charged antibacterial toothpaste abrasive contains ferroelectric ceramics. The above-mentioned ferroelectric ceramics are potassium sodium niobate K 0.5 Na 0.5 NbO3, barium titanate BaTiO3, lithium niobate LiNbO3, barium strontium titanate Ba x Sr 1-x TiO3 and is at least one or more composites or compositions selected therefrom, where 0 < x < 1. In the antibacterial toothpaste of this application, the charged antibacterial toothpaste abrasive can maintain good electrical stability, utilize the polarization effect, enable the antibacterial toothpaste containing it to exert a continuous antibacterial effect, and have good antibacterial performance, and can achieve the dual effects of tooth cleaning and antibacterial.

[0051] As should be understood, the terms "comprises," "including," or any other variations thereof, as used herein, are intended to cover non-exclusive inclusions, whereby a process, method, article, or apparatus comprising a set of elements not only includes those elements, but also includes other elements not expressly listed, or elements inherent in such process, method, article, or apparatus. Absent further limitations, elements qualified by the phrase "comprises a..." do not exclude the presence of other similar elements in the process, method, article, or apparatus that comprises said elements. The embodiments in this specification are described in a related manner, and the homologous or similar parts of the embodiments may be referred to each other, with the emphasis being on the differences between each embodiment and the other embodiments. The above description is merely a preferred embodiment of the present application and is not intended to limit the scope of protection of the present application. Any modifications, equivalent replacements, improvements, etc. made within the scope of the present application without departing from the spirit and principles of the present application are all included in the scope of protection of the present application.

Claims

1. 1. An antibacterial toothpaste comprising an electrically charged antibacterial toothpaste abrasive, The electrostatically charged antibacterial toothpaste abrasive contains a ferroelectric ceramic, and the ferroelectric ceramic is barium strontium titanate Ba ｘ Sr １－ｘ TiO ３ where 0<x<1, the ferroelectric ceramic includes ferroelectric ceramic particles or ferroelectric ceramic fibers, the particle size of the ferroelectric ceramic particles is 1 to 3 μm, and the ferroelectric ceramic fibers have an aspect ratio of 1 to 6, a length of 1 to 6 μm, and a diameter of 200 to 400 nm; Based on the weight percentage of the antibacterial toothpaste, the total weight of the charged antibacterial toothpaste abrasive and the regular toothpaste abrasive is 40 to 50 wt %, and the weight ratio of the charged antibacterial toothpaste abrasive to the regular toothpaste abrasive is 1: (0 to 1). An antibacterial toothpaste characterized by

2. The ferroelectric ceramic has been subjected to corona polarization treatment in advance.

10. The antibacterial toothpaste of claim 1.

3. The parameters of the corona polarization treatment include a polarization voltage of 1 to 30 kV, a polarization distance of 1 to 50 mm, and a polarization time of 1 to 60 min.

3. The antibacterial toothpaste of claim 2.

4. The Mohs hardness of the abrasive of the electrostatically charged antibacterial toothpaste is 2 to 4.

10. The antibacterial toothpaste of claim 1.

5. The abrasive in the conventional toothpaste is at least one selected from calcium carbonate, silicon dioxide, aluminum hydroxide, calcium hydrogen phosphate, and calcium pyrophosphate.

10. The antibacterial toothpaste of claim 1.

6. The antibacterial rate of the antibacterial toothpaste is 15-99.99%. An antibacterial toothpaste according to any one of claims 1 to 5.

7. The antibacterial rate of the antibacterial toothpaste is 30-99.99%.

7. The antibacterial toothpaste of claim 6.

8. The antibacterial rate of the antibacterial toothpaste is 40-99.99%.

8. The antibacterial toothpaste of claim 7.

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