Calculation system, calculation system control method, and calculation program

Abstract

To find leakage of a chemical solution with higher accuracy.SOLUTION: A calculation system for dividing an injection pressure of a chemical liquid by an injection speed of the chemical liquid includes a computer, and the computer acquires the injection speed, acquires the injection pressure after the injection of the chemical liquid is started, and calculates a calculation value by dividing the acquired injection pressure by the acquired injection speed.SELECTED DRAWING: Figure 5

Description

[Technical Field]

[0001] The present invention relates to a calculation system, a control method for the calculation system, and a calculation program for dividing the injection pressure of a medicinal liquid by the injection rate of the medicinal liquid. [Background technology]

[0002] Patent Document 1 describes a liquid injector that displays an actual injection pressure curve as a graph showing changes in injection pressure over time. This liquid injector performs a test injection to confirm whether the liquid injection path is properly secured. The liquid injector then calculates the injection pressure over time from the start of the test injection based on test injection condition data, and creates and displays an ideal injection pressure curve. This allows the operator of the liquid injector to determine that the injection needle has punctured a location other than the subject's blood vessel if the actual injection pressure curve remains significantly higher than the ideal injection pressure curve. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] International Publication No. 2008 / 126854 Summary of the Invention [Problem to be solved by the invention]

[0004] By monitoring the injection pressure, the operator can predict, to some extent, whether the injection needle has been inserted into a location other than the blood vessel. In other words, the operator can predict, to some extent, whether the drug solution is leaking out of the blood vessel (hereinafter also referred to as drug solution leakage). If the amount of drug solution leakage is large, there is a risk of compartment syndrome, so it is desirable to detect drug solution leakage early and stop the injection of the drug solution. Therefore, a more accurate method for predicting drug solution leakage is needed. Through extensive research, the inventors of the present invention have discovered that drug solution leakage can be predicted based on a value calculated by dividing the drug solution injection pressure by the drug solution injection rate. [Means for solving the problem]

[0005] A calculation system according to one embodiment includes a computer, and divides an injection pressure of a medicinal solution by an injection rate of the medicinal solution, The computer obtaining the infusion rate; The injection pressure after starting the injection of the medicinal liquid is acquired; The calculated value is calculated by dividing the obtained injection pressure by the obtained injection rate.

[0006] Further, a control method according to another aspect is a control method for a calculation system including a computer, the calculation system dividing an injection pressure of a medicinal liquid by an injection rate of the medicinal liquid, the method comprising: The computer obtaining the infusion rate; The injection pressure after starting the injection of the medicinal liquid is acquired; The obtained injection pressure is divided by the obtained injection rate to obtain a calculated value.

[0007] Furthermore, a calculation program according to another aspect is a calculation program that causes a computer to divide an injection pressure of a medicinal liquid by an injection rate of the medicinal liquid, The computer, obtaining the infusion rate; acquiring the injection pressure after starting the injection of the medicinal liquid; The obtained injection pressure is divided by the obtained injection rate to obtain a calculated value. [Brief explanation of the drawings]

[0008] [Figure 1] FIG. 1A shows the equations representing the IPIR ratio model, and FIG. 1B shows the equations representing the injection pressure model. [Figure 2] 1 shows the ROC curve for the IPIR ratio model. [Figure 3] 1 shows the ROC curve for the injection pressure model. [Figure 4] FIG. 1 is a schematic diagram illustrating the overall configuration of a computing system. [Figure 5] FIG. 1 is a schematic block diagram of a computing system. [Figure 6] FIG. 10 is a diagram showing an example of an in-injection screen. [Figure 7] FIG. 10 is a diagram showing another example of the in-injection screen. [Figure 8] 10 is a flowchart of a process for calculating an IPIR ratio. DETAILED DESCRIPTION OF THE INVENTION

[0009] Hereinafter, exemplary embodiments for carrying out the present invention will be described in detail with reference to the drawings. However, the dimensions, materials, shapes, and relative positions of components described in the following embodiments can be arbitrarily set and can be changed depending on the configuration of the device or method to which the present invention is applied, or various conditions. Furthermore, unless otherwise specified, the scope of the present invention is not limited to the embodiments specifically described below.

[0010] In the following description, unless otherwise specified, the term contrast agent includes both a contrast agent alone, such as an iodine or gadolinium compound, and a liquid drug containing a contrast agent plus other solvents and additives.

[0011] [IPIR ratio] With reference to Figures 1 to 3, the calculated value obtained by dividing the injection pressure of a liquid medicine by the injection rate of the liquid medicine (hereinafter referred to as the "IPIR ratio (Injection Pressure to Injection Rate ratio)") will be described. Figure 1A shows an equation representing the IPIR ratio model, and Figure 1B shows an equation representing the injection pressure model. The injection rate is the amount of liquid medicine injected per unit time. As an example, the injection rate is expressed as the amount of liquid medicine injected per second (mL / sec). The liquid medicine includes a contrast medium, saline, a mixture thereof, etc.

[0012] One possible way to determine whether or not a drug solution is leaking is to monitor the injection pressure of the drug solution. However, the injection pressure also varies depending on the injection rate of the drug solution. Therefore, it is difficult to quickly determine whether or not a drug solution is leaking based on the injection pressure. Therefore, the inventors of the present invention hypothesized that, assuming a conduit consisting of an extension tube, an indwelling needle, and a blood vessel, if the pressure difference between both ends of the conduit is proportional to the flow rate, the IPIR ratio would vary depending on whether or not a drug solution is leaking, rather than the injection rate. They then investigated whether or not a drug solution leak could be accurately determined early by evaluating the IPIR ratio.

[0013] Specifically, 49,744 cases were studied in which iodine contrast was injected using a power injector and images were taken using a computed tomography (CT) scanner. These 49,744 cases were then stratified randomly assigned in a 4:1 ratio to a train group used to estimate model parameters and a test group used to evaluate model performance. Furthermore, the stratified randomization method divided the cases into those with and without drug leakage. As a result, 39,795 cases were assigned to the train group. Of the train group, 83 cases (i.e., 0.21% of the total) had drug leakage. Furthermore, 9,949 cases were assigned to the test group. Of the test group, 21 cases (i.e., 0.21% of the total) had drug leakage.

[0014] Furthermore, for each case, we extracted the injection pressure data recorded every 0.25 seconds from the start of injection until 6 seconds had elapsed. We then extracted the injection rate set on the power injector at 1, 2, 3, 4, 5, and 6 seconds after the start of injection. We then constructed a logistic regression model (hereinafter referred to as the "IPIR ratio model") using the IPIR ratio calculated for each time point as the independent variable and the presence or absence of leakage as the objective variable. Specifically, we constructed six IPIR ratio models for each time point from 1 second to 6 seconds.

[0015] Furthermore, to evaluate the performance of the IPIR ratio model, a logistic regression model (hereinafter referred to as the "infusion pressure model") was constructed, in which the infusion pressure was used as the explanatory variable and the presence or absence of drug leakage was used as the objective variable. Specifically, as with the IPIR ratio model, six infusion pressure models were constructed for each timing interval from 1 second to 6 seconds.

[0016] The constructed IPIR ratio model is represented by the equation (logistic function) in Figure 1A, and the constructed injection pressure model is represented by the equation (logistic function) in Figure 1B.

[0017] For the IPIR ratio model and the infusion pressure model, the receiver operating characteristic curve (ROC curve) and area under the curve (AUC) were calculated for the test group. Specifically, the six ROC curves shown in Figure 2 were obtained for the IPIR ratio model. The six ROC curves shown in Figure 3 were obtained for the infusion pressure model. The performance of the IPIR ratio model and the infusion pressure model was then evaluated. In Figures 2 and 3, the vertical axis represents the true positive rate (TPR), and the horizontal axis represents the false positive rate (FPR).

[0018] As shown in Figure 2, the IPIR ratio model showed a larger AUC as the time from the start of injection increased. Furthermore, as shown in Figures 2 and 3, the IPIR ratio model showed a larger AUC than the injection pressure model. This indicates that monitoring the IPIR ratio can detect drug leakage with higher accuracy than monitoring the injection pressure. The IPIR ratio model can also be used to detect drug leakage with higher accuracy when a gadolinium compound is used as the contrast agent. That is, even when a gadolinium compound is used as the contrast agent, the IPIR ratio fluctuates, affecting the presence or absence of drug leakage.

[0019] In addition, p-values ​​corresponding to each timing from 1 second to 6 seconds were calculated. As a result, the p-value was 0.518 at 1 second, 0.535 at 2 seconds, 0.139 at 3 seconds, 0.053 at 4 seconds, 0.014 at 5 seconds, and 0.012 at 6 seconds. This indicates that drug solution leakage can be detected with significantly higher accuracy by the IPIR ratio at 4 seconds, more preferably 5 seconds, and even more preferably 6 seconds after the start of drug solution injection.

[0020] [Embodiment] As an example of a computing system, an injection system 120 and an imaging system 130 will be described with reference to Fig. 4. In Fig. 4, the dotted lines connecting the components of the computing system indicate paths for transmitting and receiving data.

[0021] [Injection System] Injection system 120 includes injection head 20, which is an example of an injection device that injects a medicinal liquid according to an injection protocol. Injection system 120 also includes console 23 that is connected to injection head 20 by wire or wirelessly. Console 23 functions as a control device that controls injection head 20. Injection system 120 also includes stand 22 that holds injection head 20. Alternatively, a hanging member may be provided instead of stand 22, and injection head 20 may be suspended from the ceiling via the hanging member.

[0022] Console 23 includes a touch panel 26 that functions as a display device and an input device. Alternatively, injection system 120 may include, instead of console 23, a control device connected to injection head 20 and a display device (e.g., a tablet terminal or touch panel display) connected to the control device but separate from the control device. In this case, injection head 20 and the control device may be configured integrally with stand 22. In addition to console 23, injection system 120 may also include another display device.

[0023] Touch panel 26 can display the injection protocol, the input status of the device, the setting status, the injection results, various information, etc. The operator can also use touch panel 26 to input medicinal solution information, the medicinal solution injection protocol, site information, subject information, etc. Alternatively, instead of touch panel 26, injection system 120 may include a display as a display device and an input device such as a keyboard or numeric keypad as an input unit.

[0024] For example, the liquid medicine information is information about the liquid medicine, including the name of the liquid medicine, the content of the contrast agent alone (e.g., the iodine content), viscosity, and the concentration of the contrast agent alone. The injection protocol includes the injection time, injection rate, and injection amount. The site information is information that identifies the selected site. For example, the site information is the name of the site that identifies the selected site, and identifies the head, brain, chest, coronary artery, right ventricle, left ventricle, abdomen, lower limbs, upper limbs, lungs, liver, stomach, spleen, pancreas, intestines, kidneys, ascending aorta, descending aorta, abdominal aorta, etc. The subject information is information about the subject, including weight, height, sex, name, etc.

[0025] Other examples of injection protocols may include information such as the injection method, injection site of the drug solution, injection ratio, mixed injection ratio, injection timing, concentration of the contrast agent alone, pressure limit, injection rate acceleration, whether or not to use a boost injection of contrast agent with saline, whether or not to increase or decrease the injection rate, whether or not to use cross injection, whether or not to use link speed settings, needle diameter, tubing diameter, and volume of the injection tubing. Cross injection is an injection method in which contrast agent is injected at a rate faster than the injection rate of saline for a set time from the start of injection, and then contrast agent is injected so that the injection rate gradually decreases, while saline is simultaneously injected so that the injection rate gradually increases. Link speed settings are settings that link the injection rates of the contrast agent and saline so that they are the same.

[0026] Injection head 20 is configured to mount a syringe filled with a medicinal liquid. Injection head 20 then injects the medicinal liquid, such as physiological saline and various contrast agents, stored in the syringe into the subject. Before the medicinal liquid is injected, an accessory such as an extension tube is connected to the tip of the syringe mounted on injection head 20. When injection begins, the medicinal liquid is pushed out of the syringe and injected into the subject via the extension tube.

[0027] The injection head 20 includes a drive mechanism that pushes the liquid drug from the syringe in accordance with the injection protocol. For example, the injection head 20 includes a presser that pushes the liquid drug from the syringe. Specifically, the presser presses the rear end of the syringe, i.e., the rear end of the piston inserted inside the syringe. The drive mechanism is connected to a drive source, and the drive force transmitted from the drive source moves the presser forward or backward.

[0028] Furthermore, the injection head 20 is equipped with a pressure detection device such as a load cell that detects the injection pressure of the medicinal liquid. Another example of a pressure detection device may be a calculation device that calculates the injection pressure based on the motor power of a motor connected to the drive mechanism as a drive source. The injection head 20 also includes a head display HD as an example of a display device. This head display HD displays the injection conditions, injection status, input status of the device, setting status, and various injection results. For example, the head display HD may be a touch panel display that can be operated by the operator.

[0029] The injection head 20 may also have a remote control device (e.g., a hand switch or foot switch) for remotely operating the injection head 20. This remote control device can remotely operate the injection head 20 to start or stop injection. The remote control device may be connected to the injection head 20 or the console 23 by wire or wirelessly. The injection head 20 may also have a power source or battery. This power source or battery can be provided in either the injection head 20 or the control device, or it can be provided separately.

[0030] The injection head 20 may also be capable of mounting various syringes, including prefilled syringes with data carriers such as RFID chips, IC tags, or barcodes. The data carriers store information about the medicinal liquid. When the injection head 20 is capable of mounting a syringe with a data carrier, it includes a reading unit that reads the data carrier attached to the syringe. For example, the reading unit is a non-contact reading device that reads the medicinal liquid information from the data carrier. Furthermore, the injection head 20 may be configured to mount three or more syringes, or only one syringe.

[0031] [Imaging system] The imaging system 130 includes a medical imaging device 30 that captures an image of a subject. The imaging device 30 is connected to the injection system 120 by wire or wirelessly. Examples of the imaging device 30 include various medical imaging devices such as an MRI (Magnetic Resonance Imaging) device, a CT (Computed Tomography) device, an angio imaging device, a PET (Positron Emission Tomography) device, a SPECT (Single Photon Emission Computed Tomography) device, a CT angio device, an MR angio device, an ultrasound diagnostic device, and a vascular imaging device. The following mainly describes an example in which the imaging device 30 is a CT device.

[0032] The imaging device 30 has an imaging section 31 that images a subject according to an imaging plan, and a control device 32 that controls the entire imaging device 30. This imaging plan includes, for example, the imaging region, effective tube voltage, model name, manufacturer name, imaging time, tube voltage, imaging range, rotation speed, helical pitch, exposure time, dose, and imaging method. The control device 32 then controls the imaging section 31 to image the subject according to the imaging plan. The imaging device 30 also has a display 33.

[0033] The imaging unit 31 has a bed, an X-ray source that irradiates the subject with X-rays, and an X-ray detector that detects the X-rays that have passed through the subject. The imaging unit 31 then exposes the subject to X-rays and captures a tomographic image of the subject by back-projecting the interior of the subject based on the X-rays that have passed through the subject. Alternatively, the imaging unit 31 may expose the subject to X-rays and capture a fluoroscopic image of the subject.

[0034] The display 33, an example of a display device, is connected to the control device 32 and displays the input status, setting status, imaging results, and various information of the device. Alternatively, the control device 32 and the display 33 may be configured integrally. Furthermore, the imaging device 30 has an interface 34 such as a keyboard that functions as an input unit. An operator can input imaging plans, drug solution information, injection protocols, subject information, and the like into the imaging device 30 from the interface 34. The display 33 may be a touch panel that functions as an input display device. In this case, the display 33 also functions as a substitute for the interface 34.

[0035] The control device 32 also includes an imaging storage unit that stores examination information related to the examination. For example, the examination information includes information identifying the imaging region, a pressure limit, an amount of iodine per unit of body weight per time, a tube voltage (kV), a tube current (mA), an examination number, an examination ID, an examination date and time, a type of liquid medicine, a name of the liquid medicine, and characteristics of the imaging device 30. The information identifying the imaging region is information that can identify a region or area to be selected as an imaging target. For example, the information identifying the imaging region includes the name of the examination region, the name of the imaging method, or the distance from the injection site of the liquid medicine to the examination region.

[0036] [Control system] 5, a control system of injection system 120, which is an example of a calculation system that divides the injection pressure of a medicinal liquid by the injection rate of the medicinal liquid, will be described. Injection system 120 includes injection head 20 and console 23 as a control device. Console 23 includes touch panel 26 as a display device, control unit 41, and memory unit 42.

[0037] The control unit 41 is a processor that executes various calculation processes and operational control according to a predetermined program. This processor is configured as a computer that combines an internal memory necessary for the processor's operation with other peripheral devices. For example, the processor may be a CPU (Central Processing Unit) or an MPU (Micro-Processing Unit), and controls the entire injection system 120 and also comprehensively controls various processes based on a control program PG, which is an example of a calculation program stored in the storage unit 42.

[0038] A touch panel 26 is also connected to the control unit 41 as an input unit for inputting predetermined commands and data. The touch panel 26 also functions as a display device that displays an injection screen (described later), the input status of the device, the setting status, the measurement results, and various information. Furthermore, the control unit 41 may perform control according to a program stored in a portable recording medium such as a CD (Compact Disc), a DVD (Digital Versatile Disc), a CF (Compact Flash) card, a microSD card, or a USB (Universal Serial Bus) memory, or in an external storage medium such as a server connected to the Internet or a LAN. Examples of the server include a RIS (Radiology Information System), a PACS (Picture Archiving and Communication System), an HIS (Hospital Information System), an image inspection system, and an image creation workstation.

[0039] The control unit 41 has an acquisition unit 41A, an injection control unit 41B, a calculation unit 41C, a display control unit 41D, and an output control unit 41E. Each unit is a logical device realized by a combination of the hardware resources of the control unit 41 and a control program PG as a software resource. Note that at least some of these logical devices may be provided outside the console 23. In this case, the control unit 41 has only some of these logical devices.

[0040] The storage unit 42 is a computer-readable non-transitory recording medium and includes a RAM (Random Access Memory), which is a system work memory for the processor of the control unit 41 to operate, a ROM (Read Only Memory) for storing programs and system software, and storage devices such as an HDD (Hard Disc Drive) and an SSD (Solid State Drive).

[0041] The storage unit 42 also stores a control program PG, which also functions as a calculation program that causes the control unit 41 (computer) to divide the injection pressure of the medicinal liquid by the injection rate of the medicinal liquid. The control program PG also causes the control unit 41 (computer) to function as an acquisition unit 41A, an injection control unit 41B, a calculation unit 41C, a display control unit 41D, and an output control unit 41E.

[0042] The control program PG can also be stored in other computer-readable non-transitory recording media. Furthermore, the memory unit 42 stores display information D1, which is referenced when displaying the screens displayed by the touch panel 26 and the head display HD. The memory unit 42 also stores infusion information D2, which is information related to the infusion of medicinal liquids. For example, the infusion information D2 is used to generate an infusion protocol, which is the infusion conditions for the medicinal liquid. For example, the infusion information D2 includes information such as a formula for calculating the IPIR ratio, a formula for calculating the leakage probability, a predetermined infusion rate, a set value for the infusion rate set by the operator, and a formula for calculating the infusion rate.

[0043] [Acquisition method] Acquisition unit 41A, which serves as an acquisition means, acquires the injection rate. For example, acquisition unit 41A acquires a predetermined default value for the injection rate or a set value set as the injection rate for injection head 20, which injects the medicinal liquid. Acquisition unit 41A may also acquire an injection rate calculated based on the drive amount of the drive mechanism that pushes out the medicinal liquid in injection head 20. As an example, the default value is stored in advance in storage unit 42. The set value is input by an operator and stored in storage unit 42. Alternatively, the set value is calculated by injection control unit 41B and stored in storage unit 42. Acquisition unit 41A then acquires the default value or the set value stored in storage unit 42.

[0044] The set value and the default value may be values ​​that vary during the injection of the medicinal solution or may be constant values. Furthermore, the default value may be a value obtained in advance based on the injection rates used in the examinations of multiple subjects. For example, the default value in this case is a representative value such as the average, median, or mode of the injection rates used in the examinations.

[0045] Furthermore, the acquisition unit 41A acquires the injection pressure after the start of the injection of the liquid medicine. As an example, the acquisition unit 41A acquires the injection pressure detected by a pressure detection device. Specifically, the acquisition unit 41A acquires the injection pressure at any timing after 4 seconds have elapsed since the start of the injection of the liquid medicine. In this case, the acquisition unit 41A acquires the injection rate at any timing after 4 seconds have elapsed since the start of the injection, which is the timing for acquiring the injection pressure. For example, the acquisition unit 41A acquires the injection pressure and the injection rate every second at 4 seconds, 5 seconds, and 6 seconds after the start of the injection. After 4 seconds have elapsed since the start of the injection of the liquid medicine, the IPIR ratio can detect liquid medicine leakage with higher accuracy. Therefore, it is more preferable to calculate the IPIR ratio using the injection pressure acquired at any timing after 4 seconds have elapsed.

[0046] The acquisition unit 41A acquires the injection pressure in real time in parallel with the injection of the medicinal liquid. Alternatively, the timing for acquiring the injection pressure may be predetermined, and the acquisition unit 41A may acquire in advance an injection rate that is a default or preset value set for the injection pressure acquisition timing, and acquire only the injection pressure in real time. The acquisition unit 41A may also acquire the injection pressure and the injection rate at the same time. Alternatively, the acquisition unit 41A may acquire the injection pressure and the injection rate recorded during the injection after the injection of the medicinal liquid is completed. That is, the acquisition unit 41A may acquire the injection pressure stored as a record as the injection pressure after the start of the injection of the medicinal liquid. For example, the acquisition unit 41A may acquire the injection pressure and the injection rate from the storage unit 42, the imaging device 30, a server, or the like. In this case, the acquired injection pressure and the injection rate are used to verify the leakage of the medicinal liquid after the inspection.

[0047] The acquisition unit 41A may acquire the injection pressure periodically, not every second, but at intervals shorter than one second (e.g., 0.25 seconds) or longer than one second (e.g., 1.5 seconds). The acquisition unit 41A may also repeatedly acquire the injection pressure even after six seconds have elapsed since the start of injection. For example, the acquisition unit 41A may repeatedly acquire the injection pressure until the injection of the medicinal liquid is completed. Alternatively, the acquisition unit 41A may stop acquiring the injection pressure when a predetermined time (e.g., 10 seconds) has elapsed since the start of injection. Furthermore, the acquisition unit 41A may acquire the injection pressure and injection rate at any predetermined timing. For example, the arbitrary timing can be preset by the operator.

[0048] The acquisition unit 41A also acquires the change in injection pressure from the start of injection of the medicinal liquid. That is, the acquisition unit 41A acquires the change in injection pressure over time. For example, the acquisition unit 41A acquires the injection pressure for each timing corresponding to the acquired injection pressure in association with the elapsed time from the start of injection, and stores the acquired injection pressure in the storage unit 42 as the change in injection pressure. In other words, the acquisition unit 41A stores the injection pressure acquired at the timing in association with the elapsed time as the timing at which the injection pressure is acquired in the storage unit 42. This allows the acquisition unit 41A to acquire the change in injection pressure over time.

[0049] The acquisition unit 41A also acquires the injection information D2, site information, subject information, and medicinal liquid information. For example, the acquisition unit 41A acquires various information input by the operator from the storage unit 42 via the touch panel 26. As another example, the acquisition unit 41A may acquire medicinal liquid information read by a reading unit that reads data carriers. Note that, if not necessary, the acquisition unit 41A may not acquire at least one of the injection information D2, site information, subject information, and medicinal liquid information. Alternatively, the acquisition unit 41A may acquire the injection rate from the imaging device 30 or a server, etc. When acquiring information from a server, the console 23 and the server function as a whole as a computing system.

[0050] [Injection control means] The injection control unit 41B, which serves as an injection control means, generates an injection protocol based on various information acquired from the acquisition unit 41A. The injection control unit 41B may also acquire an injection protocol input by an operator. Furthermore, the injection control unit 41B may acquire the injection protocol from the storage unit 42, a server, or the imaging device 30. The injection protocol includes, for example, the injection time and injection rate of the medicinal liquid. Furthermore, the injection protocol may be composed of multiple injection phases.

[0051] For example, the injection control unit 41B calculates the injection rate of the medicinal liquid based on the body weight of the subject to generate an injection protocol. Alternatively, the injection control unit 41B may calculate the injection rate based on the adjusted body weight. For example, the injection control unit 41B calculates the adjusted body weight by multiplying the value obtained by dividing the body surface area of ​​the subject by the body surface area calculated based on a standard body weight (e.g., 60 kg) by the standard body weight. Then, the injection control unit 41B calculates the injection amount of the contrast agent per second by multiplying the value obtained by multiplying the adjusted body weight by the amount of contrast agent (e.g., iodine amount) per body weight per second by the contrast agent content (e.g., iodine content).

[0052] Note that body surface area can be calculated using known methods. For example, body surface area can be calculated using the Fujimoto method, Dupois method, or Shintani method. Furthermore, body surface area may be calculated using the Livingstone & Lee method. This method allows body surface area to be calculated based only on body weight.

[0053] Alternatively, the injection control unit 41B may calculate the injection rate using a known calculation method. For example, the lean body weight (LBW) calculation method, the body surface area (BSA) calculation method, or the circulating blood volume (BV) calculation method may be used. Alternatively, the injection control unit 41B may calculate the injection rate using a regression equation obtained by performing regression analysis on statistical data. Furthermore, the injection control unit 41B may calculate the injection rate based on other physical information.

[0054] When the operator presses the start button on injection head 20, injection control unit 41B starts injecting the medicinal liquid according to the injection protocol. For example, injection control unit 41B advances the presser according to the injection protocol. As a result, when the piston advances, the medicinal liquid inside the syringe is pushed out. The pushed-out medicinal liquid is then injected into the subject's body via an extension tube connected to the tip of the syringe and a mixing device, etc. The acquisition unit 41A also acquires the injection pressure while the medicinal liquid is being injected. When the injection control unit 41B has injected the amount of medicinal liquid according to the injection protocol, it ends the injection of the medicinal liquid.

[0055] [Calculation method] The calculation unit 41C as a calculation means divides the injection pressure acquired by the acquisition unit 41A by the injection rate acquired by the acquisition unit 41A to calculate a calculated value (i.e., IPIR ratio). For example, the calculation unit 41C divides the injection pressure acquired by the acquisition unit 41A by a default or set value as the injection rate to calculate a calculated value. As an example, the calculation unit 41C calculates the IPIR ratio when the injection pressure is 5.4 kg / cm. 2 Dividing this by the set value of 3.0 mL / sec gives an IPIR ratio of 1.8 kg s / cm 5 Calculate.

[0056] Although injection pressure tends to increase with the occurrence of a drug leak, it also tends to increase in proportion to the injection rate. Therefore, by calculating the IPIR ratio, which is injection pressure divided by the injection rate, the effect of injection rate on injection pressure is offset. As a result, the distribution range of whether or not a drug leak occurs for the IPIR ratio over time is narrower than the distribution range of whether or not a drug leak occurs for the injection pressure over time. Therefore, the overlap between the distribution range of cases with a drug leak for the IPIR ratio and the distribution range of cases without a drug leak for the IPIR ratio is smaller than in the case of injection pressure. As a result, by having the operator monitor the IPIR ratio, drug leaks can be detected with greater accuracy than by monitoring the injection pressure. Alternatively, calculating the IPIR ratio allows for retrospective verification of whether or not a drug leak has occurred.

[0057] The calculation unit 41C also calculates the transition of the calculated value from the start of the injection of the medicinal liquid. That is, the calculation unit 41C calculates the transition of the IPIR ratio over time. For example, the calculation unit 41C calculates the IPIR ratio for each timing corresponding to the injection pressure acquired by the acquisition unit 41A, associates it with the elapsed time from the start of the injection, and stores it in the memory unit 42 as the transition of the IPIR ratio. In other words, the calculation unit 41C associates the IPIR ratio calculated based on the injection pressure at that timing with the elapsed time corresponding to the timing at which the injection pressure was acquired, and stores it in the memory unit 42. This allows the calculation unit 41C to calculate the transition of the IPIR ratio over time.

[0058] Furthermore, the calculation unit 41C calculates the leakage probability, which is the probability that the liquid medicine will leak, based on the calculated value. For example, the calculation unit 41C calculates the leakage probability by substituting the calculated IPIR ratio into the equation representing the IPIR ratio model shown in FIG. 1A. In this case, the leakage probability is a value greater than 0 and less than 1. The closer the leakage probability is to 0, the lower the possibility that a liquid medicine leak will occur or has occurred. On the other hand, the closer the leakage probability is to 1, the higher the possibility that a liquid medicine leak will occur or has occurred.

[0059] [Display control means] The display control unit 41D, which serves as a display control means, displays the information acquired by the acquisition unit 41A and the information calculated or computed by the calculation unit 41C on the touch panel 26 or the head display HD. The display control unit 41D also displays information read from the storage unit 42 or information input by the operator on the touch panel 26 or the head display HD. For example, the display information D1 stored in the storage unit 42 includes data indicating the screen configuration and image data of buttons, icons, and the like to be placed on the screen. The display control unit 41D then reads the data indicating the screen configuration and the image data to configure and display each screen.

[0060] Various screens that the display control unit 41D uses to display information on the touch panel 26 or the head display HD will be described with reference to Figures 6 and 7. Figures 6 and 7 show examples of screens that are displayed on the touch panel 26 or the head display HD, respectively.

[0061] The display control unit 41D outputs calculated value information based on the calculated value. Specifically, the display control unit 41D outputs the calculated value information by displaying it on the touch panel 26 or the head display HD, which are examples of a display device. For example, the calculated value information is the calculated value itself or information generated based on the calculated value. As an example, the calculated value information includes the calculated value, the difference between the calculated value and a predetermined threshold, the ratio of the calculated value to the predetermined threshold, and the risk of drug solution leakage based on the difference between the calculated value and the predetermined threshold. Here, the predetermined threshold is set according to the leakage probability calculated using the IPIR ratio. As an example, the predetermined threshold is the IPIR ratio value at which the leakage probability is 0.8. This threshold is the IPIR ratio value at which the probability of leakage reaches 80%.

[0062] For example, in FIG. 6, which shows an example of an infusion screen after infusion of a medicinal solution has started, the touch panel 26 or head display HD displays the IPIR ratio as calculated value information in the IPIR field 7X. This allows the operator to monitor the calculated value information. This allows the operator to detect medicinal solution leakage with higher accuracy. Alternatively, the output control unit 41E may output the calculated value information to an audio output device such as a speaker or earphones (not shown).

[0063] Furthermore, the display control unit 41D outputs probability information indicating the probability of leakage based on the probability of leakage. For example, the probability information is numbers, letters, or scales indicating the probability of leakage. Alternatively, the probability information may be output from the display device by varying the brightness, size, luminance, density, saturation, contrast, resolution, or the like depending on the level of the probability. Furthermore, the probability information may be output from the display device by varying the color, shape, or size, blinking of the image, movement of the image, or other aspects from other displays depending on the level of the probability.

[0064] For example, the display control unit 41D outputs the probability information by displaying it on the touch panel 26 or head display HD, which are examples of display devices. This allows the operator to monitor the probability information. Therefore, the operator can detect drug solution leakage with higher accuracy. For example, the probability information is numbers, letters, colors, lights, images, etc., indicating the leakage probability. In the example of FIG. 6, the touch panel 26 or head display HD displays a risk indicator 7Y indicating the probability information. In the risk indicator 7Y, one scale is black and the remaining nine scales are white. As a result, the risk indicator 7Y indicates a leakage probability of 10% or less as probability information. In other words, the risk indicator 7Y changes the color of one additional scale to black for every 10% increase in the leakage probability. Alternatively, the output control unit 41E may output the probability information to an audio output device such as a speaker or earphones (not shown).

[0065] Furthermore, the display control unit 41D may highlight the scale of the risk indicator 7Y when the leakage probability reaches a predetermined threshold. As an example, the predetermined threshold is a value at which the leakage probability reaches 0.8 (i.e., 80%). For example, the display control unit 41D highlights the scale by changing the color of the scale to red. Alternatively, the display control unit 41D may highlight the scale by changing the brightness, size, luminance, density, saturation, contrast, resolution, or the like. Furthermore, the display control unit 41D may highlight the scale by changing the shape or size, blinking the image, moving the image, or other aspects from other displays.

[0066] The display control unit 41D also accepts a switching instruction to switch the display on the display device. For example, the in-injection screen in FIG. 6 has a switching button SB. When the operator touches this switching button SB, the display control unit 41D accepts the switching instruction. Then, the display control unit 41D hides the calculated value information. Specifically, the display control unit 41D hides the IPIR field 7X. Furthermore, the display control unit 41D may hide the probability information. For example, the display control unit 41D hides the risk indicator 7Y.

[0067] As another example of a case where a switching instruction is accepted, the display control unit 41D may pop up at least one of the calculated value information and the probability information. Alternatively, the display control unit 41D may superimpose at least one of the calculated value information and the probability information on the in-injection screen. Furthermore, the display control unit 41D may transition from the in-injection screen to a screen that displays at least one of the calculated value information and the probability information.

[0068] Furthermore, the display control unit 41D outputs a warning when the calculated value exceeds a predetermined threshold. This notifies the operator that a liquid drug leak may have occurred. For example, the infusion screen in FIG. 6 includes a warning indicator LD. The display control unit 41D then displays the warning on the display device, touch panel 26 or head display HD, by changing the color of the indicator LD. When the warning is displayed, the operator presses the stop button on the injection head 20 as necessary. This causes the injection control unit 41B to stop the injection of the liquid drug. As an example, the predetermined threshold is the IPIR ratio value at which the leakage probability is 0.8. This threshold is the IPIR ratio value at which the probability of leakage reaches 80%.

[0069] The indicator LD may also display a warning when an optical leak detection sensor attached to the subject detects a leak. In this case, the indicator LD may display a warning when the calculated value exceeds a predetermined threshold and / or when the leak detection sensor detects a leak. The indicator LD may also be switchable between displaying a warning when the calculated value exceeds a predetermined threshold and a warning when the leak detection sensor detects a leak. Furthermore, in the special case where the calculated value exceeds the predetermined threshold and the leak detection sensor detects a leak, the warning mode of the indicator LD may be different from that in the normal case. For example, the warning in the normal case may be displayed in orange, and the warning in the special case may be displayed in red.

[0070] For example, the indicator LD is green when no leak is detected and changes to orange when the calculated value exceeds a predetermined threshold. Alternatively, the indicator LD may indicate the presence or absence of a leak using other colors. Furthermore, the indicator LD may indicate a warning by changing its color, shape, size, transparency, density, chromaticity, saturation, brightness, hue, or a combination thereof, or by changing its changing mode, such as blinking.

[0071] When the operator presses the start button on injection head 20 to begin injection, display control unit 41D displays an injection in progress screen. The injection in progress screen includes a first phase field 7A1 that displays the first phase of the injection protocol and a second phase field 7A2 that displays the second phase of the injection protocol. Furthermore, if the injection protocol includes three or more phases, the injection in progress screen includes additional phase fields corresponding to the number of phases.

[0072] Furthermore, each phase column is highlighted as the injection progresses and a phase begins. Specifically, in the example of FIG. 6, the first phase has begun, so the first phase column 7A1 is highlighted brighter than the second phase column 7A2. The first phase column 7A1 in FIG. 6 displays an injection rate of 3.0 mL / sec and an injection volume of 90 mL for the contrast medium. The second phase column 7A2 in FIG. 6 displays an injection rate of 3.0 mL / sec and an injection volume of 45 mL for the saline solution. Furthermore, the injection screen has a status display column 7D that displays that injection is in progress. Specifically, the status display column 7D in FIG. 6 displays the text "injecting."

[0073] Furthermore, the in-injection screen has a remaining amount display field 7E for the liquid medicine. Specifically, in the example of FIG. 6, the remaining amount display field 7E displays 86 mL of the remaining amount in syringe A filled with contrast medium and 57 mL of the remaining amount in syringe B filled with physiological saline. The in-injection screen also has a pressure display field 7T that displays the current injection pressure of the liquid medicine. Specifically, in the example of FIG. 6, the pressure display field 7T displays an injection pressure of 5.4 kg / cm 2 is displayed. Furthermore, the in-injection screen has an elapsed time field 7U that displays the time elapsed since the start of injection. Specifically, in the example of Figure 6, the elapsed time field 7U displays an elapsed time of 4 seconds.

[0074] The display control unit 41D also displays a pressure change display field 7V, which displays a real-time graph showing the change in injection pressure over time, together with the phase field. For this reason, the injection screen is provided with a pressure change display field 7V in addition to the phase field. In this pressure change display field 7V, the vertical axis represents the injection pressure, and the horizontal axis represents the elapsed time from the start of injection. Furthermore, a pressure limit line 7V1 is displayed on the injection screen. The pressure limit line 7V1 corresponds to the set pressure limit. In the example of FIG. 6, the pressure limit value is 21.0 kg / cm. 2 is displayed in the pressure change display field 7V.

[0075] The display control unit 41D also displays a pressure graph 7V2 in the pressure change display field 7V as pressure information showing the change in injection pressure over time. This allows the operator to monitor the injection pressure in addition to the IPIR ratio. The pressure graph 7V2 is a graph showing the change in injection pressure over time acquired by the acquisition unit 41A. The display control unit 41D then displays the pressure graph 7V2 so that it is gradually drawn according to the elapsed time from the start of injection. Alternatively, the pressure information may be various graphs such as a bar graph, or a string of numbers indicating multiple injection pressures arranged in chronological order.

[0076] The pressure change display field 7V displays an injection pressure indicator 7V3 that indicates the current injection pressure. The display controller 41D changes the display position of the injection pressure indicator 7V3 depending on the injection pressure. The display mode of the injection pressure indicator 7V3 varies depending on the type of medicinal liquid being injected. For example, the indicator is displayed in green during a phase in which only contrast medium is being injected, in blue during a phase in which only saline is being injected, and in green and blue during a phase in which both are being injected.

[0077] Furthermore, the pressure change display field 7V displays a round indicator 7Z whose display position changes along with the injection pressure indicator 7V3. The display control unit 41D changes the display position of the round indicator 7Z over time. This round indicator 7Z may indicate calculated value information. For example, the round indicator 7Z gradually increases in size depending on the magnitude of the IPIR ratio. In this way, the round indicator 7Z indicates the IPIR ratio as calculated value information. Alternatively, the round indicator 7Z may indicate probability information by gradually increasing in size depending on the leakage probability.

[0078] The display control unit 41D may change the display mode of at least one of the risk indicator 7Y and the round indicator 7Z when the likelihood of leakage is higher. For example, the display control unit 41D changes the display mode by changing the color. As an example, the display control unit 41D may determine that the likelihood of leakage is higher when leakage is detected by other detection means. Examples of other detection means include an optical leakage detection sensor, a CCD (Charge Coupled Device) camera, or a temperature sensor that detects changes in body temperature. Alternatively, the display control unit 41D may determine that the likelihood of leakage is higher when the injection pressure reaches a predetermined threshold.

[0079] The in-injection screen also has a timing display field 7W that displays the imaging timing. The horizontal axis of this timing display field 7W indicates the elapsed time (seconds) with the injection start timing of the medicinal liquid as the reference (zero). Specifically, the length of the timing display field 7W matches the length of each unit time (e.g., each second) of the horizontal axis of the pressure change display field 7V. The display control unit 41D receives timing data from the imaging device 30 or the like and displays a timing indicator indicating the imaging timing in the timing display field 7W. The phase field also indicates the elapsed time with the injection start timing as the reference. Therefore, the combined length of the first phase field 7A1 and the second phase field 7A2 may match the length of each unit time of the horizontal axis of the pressure change display field 7V.

[0080] Furthermore, the display control unit 41D may display transition information showing the transition of the calculated value over time on the touch panel 26 or head display HD, which are examples of a display device. This allows the operator to monitor the IPIR ratio. For example, in FIG. 7, which is another example of an in-injection screen, the touch panel 26 or head display HD displays an IPIR ratio graph 8V2 in a transition change display field 8V as transition information. Here, the vertical axis of the transition change display field 8V represents the IPIR ratio (kg·s / cm 5 ) is shown.

[0081] The IPIR ratio graph 8V2 shows the change over time in the IPIR ratio acquired by the display control unit 41D. The display control unit 41D then displays the IPIR ratio graph 8V2 so that it is gradually drawn according to the time elapsed since the start of injection. Alternatively, the transition information may be various graphs such as a bar graph, or may be a string of numbers indicating multiple IPIR ratios arranged in chronological order.

[0082] The display control unit 41D may display the pressure graph 7V2, which is pressure information, together with the IPIR ratio graph 8V2, which is transition information. This allows the operator to monitor the infusion pressure in addition to the IPIR ratio. The IPIR ratio graph 8V2 may be displayed simultaneously with the pressure graph 7V2. For example, the IPIR ratio graph 8V2 and the pressure graph 7V2 may be displayed side by side, vertically or horizontally. The IPIR ratio graph 8V2 and the pressure graph 7V2 may be displayed on the same screen, or may be displayed simultaneously on separate screens. Alternatively, if the infusion rate is constant, the pressure graph 7V2 and the IPIR ratio graph 8V2 may be displayed as a single line. The display mode of the infusion screen shown in FIG. 7 is similar to that of the infusion screen shown in FIG. 6, and therefore a description of the screen configuration will be omitted, excluding the main differences.

[0083] Upon receiving the switching instruction, the display controller 41D may switch the display so that the transition information and the pressure information are displayed instead of or in addition to one of the transition information and the pressure information. Specifically, the injection screen in FIG. 7 is provided with a switching button SB. When the operator touches this switching button SB, the display controller 41D accepts the switching instruction. Alternatively, instead of touching the button, the operator may be able to select the switching button SB by operating an operation unit provided on the console 23, the head display HD, or the injection head 20.

[0084] Then, each time a switching instruction is received, the display control unit 41D alternates between a mode in which the pressure graph 7V2 shown in Fig. 6 is simultaneously displayed and a mode in which the IPIR ratio graph 8V2 shown in Fig. 7 is displayed. As another example, each time a switching instruction is received, the display control unit 41D may alternate between a first mode in which the pressure graph 7V2 and the IPIR ratio graph 8V2 are simultaneously displayed, a second mode in which only the IPIR ratio graph 8V2 is displayed, and a third mode in which only the pressure graph 7V2 is displayed. Alternatively, each time a switching instruction is received, the display control unit 41D may alternate between displaying and hiding the IPIR ratio graph 8V2.

[0085] The display control unit 41D outputs a warning when the calculated value exceeds a predetermined threshold. For example, the display control unit 41D displays a limit line 8V1 as shown in FIG. 7 on the touch panel 26 or head display HD, which is a display device. Then, when the calculated value exceeds the predetermined threshold, the display control unit 41D causes the IPIR ratio graph 8V2 to intersect with the limit line 8V1. This causes the display control unit 41D to output a warning on the touch panel 26 or head display HD, which are examples of display devices. Note that the IPIR ratio values ​​shown in FIG. 7 are merely examples. For example, the limit line 8V1 may correspond to a predetermined threshold at which the leakage probability reaches 0.8 (i.e., 80%). In this case, the threshold is displayed near the limit line 8V1. In addition, a warning area, which will be described later, may also correspond to a predetermined threshold at which the leakage probability reaches 0.8 (i.e., 80%).

[0086] Furthermore, instead of or in addition to the limit line 8V1, the display control unit 41D may display a warning area on the touch panel 26 or head display HD, which are examples of a display device. This warning area indicates an area on the IPIR ratio graph 8V2 where the calculated value exceeds a predetermined threshold. When the calculated value exceeds the predetermined threshold, the display control unit 41D superimposes the IPIR ratio graph 8V2 on the warning area. This causes the display control unit 41D to output a warning on the touch panel 26 or head display HD, which are examples of a display device.

[0087] As another example, the warning may be displayed by changing the brightness, size, luminance, density, saturation, contrast, or resolution of any part of the screen during injection. Furthermore, the warning may be displayed by changing the color, shape, or size of any part of the screen, blinking an image, moving an image, or other aspects of the screen that are different from other displays. Alternatively, the output control unit 41E may cause an audio output device, such as a speaker or earphones (not shown), to output a sound as a warning that the calculated value has exceeded a predetermined threshold.

[0088] [Output control means] The output control unit 41E, as an example of an output control means, causes the audio output device to output a sound indicating at least one of the calculated value information, the probability information, and the warning. For example, the sound may be a voice reading out the calculated value information or the probability information, a sound that changes depending on the calculated value or the leakage probability, or a warning sound. As another example, the output control unit 41E may output data indicating at least one of the calculated value information, the probability information, and the warning by transmitting it to an external device. Alternatively, the output control unit 41E may cause a vibration device to output a vibration to indicate the warning. Furthermore, the output control unit 41E may cause a light-emitting device to output a light to indicate the warning.

[0089] [IPIR ratio calculation process] The calculation process of the IPIR ratio will be described with reference to Fig. 8. First, the acquisition unit 41A acquires information necessary for generating an injection protocol. Then, the injection control unit 41B generates the injection protocol based on the various information acquired from the acquisition unit 41A. Next, the acquisition unit 41A acquires the injection rate (S101). For example, the acquisition unit 41A acquires a set value set as the injection rate in the injection protocol.

[0090] When the operator presses the start button on injection head 20, injection control unit 41B starts injecting the medicinal liquid according to the injection protocol (S102). Display control unit 41D displays an in-injection screen. Acquisition unit 41A acquires the injection pressure after the start of injection of the medicinal liquid (S103). Calculation unit 41C divides the injection pressure by the injection rate to calculate a calculated value (S104). Calculation unit 41C then calculates the leakage probability and computes the transition of the calculated value. Acquisition unit 41A also acquires the transition of the injection pressure.

[0091] Next, the display control unit 41D causes the touch panel 26 and the head display HD to display each piece of information, such as calculation value information based on the calculation value, transition information showing the transition of the calculation value, pressure information showing the transition of the injection pressure, and probability information (S105). Then, if the calculation value exceeds a predetermined threshold (YES in S106), the display control unit 41D causes the touch panel 26 and the head display HD to display a warning (S107).

[0092] When the warning is displayed, the operator presses the stop button on injection head 20 as necessary. This causes injection control unit 41B to stop the injection of the medicinal liquid. Furthermore, if the operator does not resume the injection of the medicinal liquid (YES in S108), injection control unit 41B ends the injection of the medicinal liquid and the process ends. On the other hand, if the calculated value does not exceed the predetermined threshold (NO in S106) or the operator does not stop the injection of the medicinal liquid (NO in S108), the injection of the medicinal liquid continues. Thereafter, injection control unit 41B ends the injection of the medicinal liquid after injecting the injection amount according to the injection protocol.

[0093] When the warning is displayed, the operator may check for the presence or absence of leakage using an optical leakage detection sensor, a CCD camera, or a temperature sensor that detects changes in body temperature. Furthermore, the operator may check for the presence or absence of leakage by visual inspection or palpation. Alternatively, the operator may check for the presence or absence of leakage by asking the subject whether they experience any pain or discomfort.

[0094] The order of processing by each logical device may be changed as appropriate. For example, the acquisition unit 41A may acquire the injection rate simultaneously with or after the acquisition of the injection pressure by the acquisition unit 41A. Furthermore, the injection control unit 41B may generate the injection protocol simultaneously with or after the acquisition of the injection rate (e.g., a default value) by the acquisition unit 41A. Furthermore, at least a part of the processing by each logical device may be omitted. For example, the processing of calculating the leakage probability, calculating the transition of the calculated value, or acquiring the transition of the injection pressure may be omitted.

[0095] The calculation system described above allows the operator to monitor the IPIR ratio. This allows the operator to detect drug leaks with greater accuracy than by monitoring the injection pressure. Alternatively, calculating the IPIR ratio allows retrospective verification of whether or not a drug leak has occurred. Furthermore, the process of preparing an optical detection device to detect drug leaks and connecting the detection device to the injection device can be omitted. Furthermore, the accuracy of detecting drug leaks rapidly increases several seconds after the start of injection. Therefore, even if a drug leak does occur, the leak can be detected early. This allows the drug injection to be terminated early, minimizing the amount of drug leakage. Furthermore, unnecessary drug injection and imaging can be avoided.

[0096] Although the present invention has been described above with reference to each embodiment, the present invention is not limited to the above-described embodiments. Inventions modified without violating the present invention, and inventions equivalent to the present invention, are also included in the present invention. Furthermore, each embodiment and each modified form, and technical means included in each embodiment or each modified form, can be combined as appropriate without violating the present invention.

[0097] For example, at least one of the functional units included in console 23 may be provided in control device 32 of imaging system 130. In this case, injection system 120 and imaging system 130 cooperate to function as a computing system. All of the functional units included in console 23 may be provided in control device 32 of imaging system 130. In this case, imaging system 130 functions as a computing system. Furthermore, at least one of the functional units included in console 23 may be provided in an external device such as a server. In this case, injection system 120 and the external device cooperate to function as a computing system. Furthermore, the computing system may be configured by a computer device and a display separate from console 23. As an example, the computing system may be configured by a desktop computer or a laptop computer. Furthermore, the computing system may be configured by the above-mentioned server or a server logically configured using cloud computing.

[0098] Furthermore, the calculation unit 41C may calculate the injection pressure for the main injection based on the injection pressure for the test injection before the main injection. In this case, the acquisition unit 41A may acquire the injection pressure calculated by the calculation unit 41C. Furthermore, the calculation unit 41C may correct the calculated IPIR ratio. As an example, the calculation unit 41C corrects the IPIR ratio by multiplying it by a coefficient that increases with elapsed time. As a result, as the elapsed time increases, the calculated value is more likely to reach the threshold value. Note that the IPIR ratio model may be constructed by further considering factors other than the IPIR ratio that affect the injection pressure.

[0099] A part or all of the above-described embodiments can be described as, but not limited to, the following supplementary notes.

[0100] (Appendix 1) A calculation system including a computer, the calculation system dividing an injection pressure of a drug solution by an injection rate of the drug solution, The computer obtaining the infusion rate; The injection pressure after starting the injection of the medicinal liquid is acquired; A computing system that calculates a calculated value by dividing the obtained injection pressure by the obtained injection rate.

[0101] (Appendix 2) The computer Acquire a predetermined value as the injection rate or a set value set as the injection rate for injecting the medicinal liquid; 2. The calculation system of claim 1, wherein the calculated value is calculated by dividing the acquired injection pressure by the default value or the set value.

[0102] (Appendix 3) 3. The calculation system according to claim 1, wherein the computer acquires the injection pressure and the injection rate at a timing after 4 seconds have elapsed since the start of injection of the medicinal solution.

[0103] (Appendix 4) 4. The computing system of claim 1, wherein the computer outputs calculated value information based on the calculated value.

[0104] (Appendix 5) the computing system includes a display device; The calculation system according to any one of appendices 1 to 4, wherein the computer calculates the change in the calculated value since the start of injection of the medicinal solution and displays change information indicating the change in the calculated value on the display device.

[0105] (Appendix 6) The calculation system described in Appendix 5, wherein the computer acquires the change in the injection pressure since the start of injection of the medicinal solution and displays pressure information indicating the change in the injection pressure together with the change information.

[0106] (Appendix 7) The computer Accept a switching instruction to switch the display of the display device; 7. The computing system of claim 6, wherein, upon accepting the switching instruction, the display is switched so that the other of the transition information and the pressure information is displayed instead of or in addition to one of the transition information and the pressure information.

[0107] (Appendix 8) 8. The computing system of claim 1, wherein the computer outputs a warning if the calculated value exceeds a predetermined threshold.

[0108] (Appendix 9) the computing system includes a display device; 9. The computing system of claim 8, wherein the computer causes the warning to be displayed on the display device.

[0109] (Appendix 10) 10. The calculation system according to any one of appendices 1 to 9, wherein the computer calculates a leakage probability, which is the probability that the medicinal solution will leak, based on the calculated value.

[0110] (Appendix 11) 11. The computing system of claim 10, wherein the computer outputs probability information indicating the leakage probability based on the leakage probability.

[0111] (Appendix 12) 12. The computing system of any one of claims 1 to 11, further comprising an injection device for injecting the medicinal liquid.

[0112] (Appendix 13) A control method for a calculation system including a computer, the method comprising: dividing an injection pressure of a medicinal liquid by an injection rate of the medicinal liquid; The computer obtaining the infusion rate; The injection pressure after starting the injection of the medicinal liquid is acquired; A control method comprising: dividing the obtained injection pressure by the obtained injection rate to calculate a calculated value.

[0113] (Appendix 14) A calculation program that causes a computer to divide an injection pressure of a medicinal liquid by an injection rate of the medicinal liquid, The computer, obtaining the infusion rate; acquiring the injection pressure after starting the injection of the medicinal liquid; A calculation program that calculates a calculated value by dividing the acquired injection pressure by the acquired injection rate. [Explanation of symbols]

[0114] 7V2: Pressure graph (pressure information) 7X: IPIR column (calculated value information) 7Y: Risk indicator (probability information) 8V2: Pressure graph (pressure information) 8V2: IPIR ratio graph (transition information) 20: Injection head (injection device) 26: Touch panel (display device) 41: Control unit (computer) 120: Injection system (calculation system) HD: Head display (display device) LD: Indicator (Warning) PG: Control program (calculation program)

Claims

1. A calculation system including a computer, the calculation system dividing an injection pressure of a drug solution by an injection rate of the drug solution, The computer obtaining the infusion rate; The injection pressure after starting the injection of the medicinal liquid is acquired; A computing system that calculates a calculated value by dividing the obtained injection pressure by the obtained injection rate.

2. The computer Acquire a predetermined value as the injection rate or a set value set as the injection rate for injecting the medicinal liquid; The calculation system according to claim 1 , wherein the calculated value is calculated by dividing the acquired injection pressure by the default value or the set value.

3. The calculation system according to claim 1 , wherein the computer acquires the injection pressure and the injection rate at a timing after 4 seconds have elapsed since the start of injection of the medicinal solution.

4. The computing system of claim 1 , wherein the computer outputs calculated value information based on the calculated value.

5. the computing system includes a display device; The calculation system according to claim 1 , wherein the computer calculates a transition of the calculated value from the start of injection of the medicinal liquid, and causes the display device to display transition information indicating the transition of the calculated value.

6. The calculation system according to claim 5 , wherein the computer acquires the change in the injection pressure since the start of injection of the medicinal solution, and displays pressure information indicating the change in the injection pressure together with the change information.

7. The computer Accept a switching instruction to switch the display of the display device; The computing system of claim 6 , wherein, when the switching instruction is accepted, the display is switched so that the other of the transition information and the pressure information is displayed instead of or in addition to one of the transition information and the pressure information.

8. The computing system of claim 1 , wherein the computer outputs a warning when the calculated value exceeds a predetermined threshold.

9. the computing system includes a display device; The computing system of claim 8 , wherein the computer causes the warning to be displayed on the display device.

10. The calculation system according to claim 1 , wherein the computer calculates a leakage probability, which is a probability that the medicinal solution will leak, based on the calculated value.

11. The computing system according to claim 10 , wherein the computer outputs probability information indicating the leakage probability based on the leakage probability.

12. The computing system according to claim 1 , further comprising an injection device for injecting the chemical solution.

13. A control method for a calculation system including a computer, the method comprising: dividing an injection pressure of a medicinal liquid by an injection rate of the medicinal liquid; The computer obtaining the infusion rate; The injection pressure after starting the injection of the medicinal liquid is acquired; A control method comprising: dividing the obtained injection pressure by the obtained injection rate to calculate a calculated value.

14. A calculation program that causes a computer to divide an injection pressure of a medicinal liquid by an injection rate of the medicinal liquid, The computer, obtaining the infusion rate; acquiring the injection pressure after starting the injection of the medicinal liquid; A calculation program that calculates a calculated value by dividing the acquired injection pressure by the acquired injection rate.

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