Cosmetic

Abstract

To provide a cosmetic excellent in feeling of use.SOLUTION: The cosmetic comprises (A) at least one of (a-1) a pyrimidyl pyrazole compound having a specific structure or its salt and (a- 2) a cyclic carboxamide derivative having a specific structure or its salt, (B) a water-absorbing polymer having a carboxy group, (C) agar and (D) water.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a cosmetic preparation. Specifically, the present invention relates to a cosmetic preparation comprising at least one of a pyrimidylpyrazole compound having a specific structure or a salt thereof, or a cyclic carboxamide derivative having a specific structure or a salt thereof, a water-absorbent polymer having a carboxyl group, and agar. [Background technology]

[0002] It has been known that by blending agar into cosmetics, it is possible to obtain cosmetics that are fresh and less sticky (for example, Patent Document 1). However, further improvements are required in cosmetics blended with agar in terms of how well they blend with the skin and how well they spread. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Publication No. 2022-158540 Summary of the Invention

[0004] The present inventors have surprisingly found that a cosmetic comprising at least one of a pyrimidylpyrazole compound having a specific structure or a salt thereof, or a cyclic carboxamide derivative having a specific structure or a salt thereof, a water-absorbent polymer having a carboxyl group, and agar can provide a fresh, non-sticky feel to the skin after application, good compatibility with the skin, and good spreadability during application. The present invention is based on these findings.

[0005] According to the present disclosure, the following inventions are provided. [1] A cosmetic comprising, as component (A), at least one of (a-1) a pyrimidylpyrazole compound represented by formula (1) or a salt thereof, or (a-2) a cyclic carboxamide derivative represented by formula (2) or a salt thereof, (B) a water-absorbent polymer having a carboxyl group, (C) agar, and (D) water. [ka] (In the formula, R 1 , R 3 , R 4 and R 6 are each independently, C 1-3 is an alkyl group, and R 2 and R 5 are each independently a hydrogen atom or C 1-3 alkyl group) [ka] (In the formula, R 21 represents a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom, X is -CH2- or -NR-, where R is a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom; and n is an integer from 1 to 3. [2]R 2 and R 5 [1] The cosmetic according to [1], wherein is a hydrogen atom. [3]R 1 , R 3 , R 4 and R 6 The cosmetic according to [1] or [2], wherein is a methyl group. [4]R 21 The cosmetic preparation according to any one of [1] to [3], wherein is a hydroxyalkyl group having 1 to 3 carbon atoms, X is -CH2- or -NH-, and n is 1. [5] The cosmetic preparation according to any one of [1] to [4], wherein the component (a-1) is dimethylpyrazolyldimethylpyrimidine hydrochloride. [6] The cosmetic preparation according to any one of [1] to [5], wherein the component (a-2) is 1-(2-hydroxyethyl)-2-imidazolidinone. [7] The cosmetic according to any one of [1] to [6], wherein the content of the component (a-1) is 0.01 to 1.5 mass % relative to the total amount of the cosmetic. [8] The cosmetic according to any one of [1] to [7], wherein the content of component (a-2) is 0.1 to 5 mass % relative to the total amount of the cosmetic. [9] A cosmetic preparation according to any one of [1] to [8], wherein the water absorption capacity of component (B) is 10 to 1000 times its own weight.

[10] The cosmetic preparation according to any one of [1] to [9], wherein the component (B) is carbomer Na.

[11] The cosmetic according to any one of [1] to

[10] , wherein the content of component (B) is 0.01 to 2 mass % relative to the total amount of the cosmetic.

[12] The cosmetic according to any one of [1] to

[11] , wherein the content of component (C) is 0.1 to 5 mass % relative to the total amount of the cosmetic.

[13] (E) The cosmetic preparation according to any one of [1] to

[12] , further comprising an oil component.

[14] The cosmetic according to any one of [1] to

[13] , which is an oil-in-water emulsion cosmetic.

[0006] According to the present invention, it is possible to provide a cosmetic product that has an excellent feeling when used. In particular, it is possible to provide a cosmetic product that has a fresh and refreshing feeling when used, that blends well with the skin after application, and that spreads easily during application.

[0007] The present invention relates to a cosmetic comprising, as component (A), at least one of (a-1) a pyrimidylpyrazole compound having a specific structure or a salt thereof, or (a-2) a cyclic carboxamide derivative having a specific structure or a salt thereof, (B) a water-absorbent polymer having a carboxyl group, (C) agar, and (D) water.

[0008] Component (A) The cosmetic preparation according to the present invention comprises, as component (A), at least one of (a-1) a pyrimidylpyrazole compound having a specific structure or a salt thereof, or (a-2) a cyclic carboxamide derivative having a specific structure or a salt thereof. Component (A) is a type of salt-type drug, which is a water-soluble drug capable of forming a salt.

[0009] (a-1) Pyrimidylpyrazole compound or salt thereof The cosmetic according to the present invention comprises (a-1) a pyrimidylpyrazole compound represented by formula (1) or a salt thereof. [ka] During the ceremony, R 1 , R 3 , R 4 and R 6 are each independently, C 1-3 It is an alkyl group, specifically a methyl group, an ethyl group, an n-propyl group, an isopropyl group, or a cyclopropyl group, preferably a methyl group or an ethyl group, more preferably a methyl group. R 2 and R 5 are each independently a hydrogen atom or C 1-3 It is an alkyl group, specifically a hydrogen atom, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, or a cyclopropyl group, preferably a hydrogen atom, a methyl group, or an ethyl group, more preferably a hydrogen atom.

[0010] The component (a-1) may be a salt of the pyrimidylpyrazole compound represented by formula (1). The type of salt is not particularly limited as long as it is pharmaceutically acceptable, and may be an inorganic salt or an organic salt. Examples of the salt include hydrochloride, hydrobromide, sulfate, phosphate, acetate, propionate, citrate, lactate, oxalate, maleate, fumarate, tartrate, and methanesulfonate. The component (a-1) is preferably dimethylpyrazolyldimethylpyrimidine hydrochloride.

[0011] The content of the component (a-1) is 0.01 to 1.5 mass % relative to the total amount of the cosmetic, more preferably 0.05 to 1.2 mass %, and even more preferably 0.1 to 1.0 mass %.

[0012] (a-2) Cyclic carboxamide derivative or salt thereof The cosmetic according to the present invention comprises (a-2) a cyclic carboxamide derivative represented by formula (2) or a salt thereof. [ka] During the ceremony, R 21 represents a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom, X is -CH2- or -NR-, where R is a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom; and n is an integer of 1 to 3. R 21 is not particularly limited and may be, for example, an alkyl group, cycloalkyl group, alkenyl group, alkynyl group, or cycloalkylalkyl group which may be substituted with a hydroxyl group, and is preferably a hydroxyalkyl group. R is also not particularly limited and may be, for example, hydrogen, or an alkyl group, cycloalkyl group, alkenyl group, alkynyl group, or cycloalkylalkyl group which may be substituted with a hydroxyl group, and is preferably hydrogen.

[0013] In a preferred embodiment, in formula (2), R 21 is a hydroxyalkyl group having 1 to 3 carbon atoms, X is -CH2- or -NH-, and n is 1. Specific examples of the cyclic carboxamide derivative represented by formula (2) include the following. [ka] The component (a-2) is most preferably 1-(2-hydroxyethyl)-2-imidazolidinone.

[0014] The component (a-2) may be a salt of the cyclic carboxamide derivative represented by formula (2). The type of salt is not particularly limited as long as it is pharmaceutically acceptable, and may be an inorganic salt or an organic salt. Examples of inorganic salts include hydrochloride, sulfate, phosphate, hydrobromide, sodium salt, potassium salt, magnesium salt, calcium salt, magnesium salt, and ammonium salt. Examples of organic salts include acetate, lactate, maleate, fumarate, tartrate, methanesulfonate, p-toluenesulfonate, triethanolamine salt, and amino acid salt.

[0015] The content of the (a-2) component is, but is not limited to, 0.1 to 5 mass % relative to the total amount of the cosmetic, more preferably 0.5 to 4 mass %, and even more preferably 1 to 3 mass %.

[0016] In the present invention, by adding component (A), it is possible to improve the compatibility and spreadability of the cosmetic while maintaining a fresh feeling.

[0017] (B) a water-absorbing polymer having a carboxyl group; (B) The water-absorbent polymer having a carboxyl group is a homopolymer or copolymer of a monomer having a carboxyl group, or a derivative thereof, and is a water-absorbent polymer having a water-absorbing capacity of preferably 10 times or more its own weight, more preferably 10 to 1000 times, and even more preferably 10 to 500 times. If the water-absorbent capacity is less than 10 times its own weight, the desired properties cannot be obtained, and if it exceeds 1000 times, wrinkling tends to occur as the absorption capacity increases.

[0018] The structure of the (B) water-absorbent polymer having a carboxyl group is not particularly limited, and may be a structure having a carboxyl group in the polymer main chain or a structure having a carboxyl group in the side chain. Preferably, a homopolymer or copolymer (graft, block, random) produced by polymerization of raw material monomers including acrylic acid monomers is used. Specific examples include polyacrylates containing crosslinked or non-crosslinked sodium polyacrylate (e.g., carbomer Na), sodium acrylate (Na) grafted starch, etc. As the (B) water-absorbent polymer having a carboxyl group, carbomer Na is preferably used.

[0019] Although not particularly limited, commercially available products can be used as the water-absorbent polymer in the present invention. Examples of such commercially available products include AQUPEC MG N40R (manufactured by Sumitomo Seika Chemicals Co., Ltd.), Makimousse 12 (average particle size: approximately 12 μm (manufactured by Daito Chemical Industry Co., Ltd.) and Makimousse 25 (average particle size: approximately 25 μm) (manufactured by Daito Chemical Industry Co., Ltd.). Among these, it is desirable to select a polymer with high water absorbency (at least 10 times its own weight).

[0020] The content of (B) the water-absorbing polymer having a carboxyl group is 0.01 to 2% by mass, preferably 0.05 to 1% by mass, and more preferably 0.1 to 0.5% by mass, relative to the total amount of the cosmetic.

[0021] In the present invention, by adding component (B), it is possible to further improve the compatibility and spreadability of the cosmetic while maintaining a fresh feeling.

[0022] (C)Agar The cosmetic according to the present invention comprises (C) agar. There are no particular limitations on the type of (C) agar, as long as it is primarily composed of agarose, which has a high gelling power. The agar may be a natural product or a processed product. Purified agar may also be used as the agar. The content of (C) agar is preferably 0.1% to 3% by mass or more, more preferably 0.2 to 1.5% by mass, based on the total mass of the cosmetic.

[0023] (D)Water The cosmetic according to the present invention comprises (D) water. The water used in cosmetics, quasi-drugs, etc. can be used, such as purified water, ion-exchanged water, tap water, etc. The water content is preferably 40 to 95% by mass, more preferably 50 to 90% by mass, based on the total amount of the cosmetic according to the present invention.

[0024] (E) Oil The cosmetic of the present invention may contain (E) an oil component in addition to (A) to (D). In such cases, the cosmetic of the present invention generally takes the form of an oil-in-water cosmetic or a water-in-oil cosmetic, but may also be, for example, a two-layer cosmetic that separates into two layers upon standing.

[0025] Examples of (E) oils include ester oils, silicone oils, hydrocarbon oils, higher fatty acids, higher alcohols, liquid oils, solid oils, and semi-solid oils. The oils are preferably ester oils, silicone oils, hydrocarbon oils, and higher alcohols. One or more types of (D) component may be blended. The content of (E) component is preferably 1 to 40% by mass of the total amount of the cosmetic.

[0026] Examples of ester oils include octyl octanoate, nonyl nonanoate, cetyl octanoate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, ethylhexyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, 12-hydroxystearate, hydroxypropyl methyl ... Cholesteryl tearic acid, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, tripropylene glycol pivalate, diisostearyl malate, glyceryl di-2-heptylundecanoate, glyceryl diisostearate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, tetra-2 -Pentaerythritol ethylhexanoate, glyceryl tri-2-ethylhexanoate, glyceryl trioctanoate, glyceryl triisopalmitate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate-2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleyl oleate, acetoglyceride, 2-heptylundecyl palmitate, Examples of suitable oleic acid surfactants include diisobutyl adipate, N-lauroyl-L-glutamic acid 2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, triethyl citrate, cetyl ethylhexanoate, and macadamia nut fatty acid phytosteryl.

[0027] Examples of silicone oils include linear polysiloxanes (e.g., dimethicone, diphenylsiloxyphenyltrimethicone, diphenylpolysiloxane, etc.), cyclic polysiloxanes (e.g., octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, etc.), silicone resins that form a three-dimensional network structure, silicone rubber, various modified polysiloxanes (amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc.), and acrylic silicones, with linear polysiloxanes being preferred.

[0028] Examples of hydrocarbon oils include isododecane, isohexadecane, isoparaffin, mineral oil (liquid paraffin), ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, and hydrogenated polydecene.

[0029] Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, tall acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

[0030] Examples of higher alcohols include straight-chain alcohols (e.g., lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, etc.), branched-chain alcohols (e.g., lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol, etc.), and the like.

[0031] Examples of liquid oils include avocado oil, camellia oil, macadamia nut oil, corn oil, olive oil, rapeseed oil, sesame oil, persic oil, wheat germ oil, camellia oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, Chinese tung oil, Japanese tung oil, jojoba oil, germ oil, triglycerin, etc. Examples of solid oils include cocoa butter, coconut oil, hydrogenated coconut oil, palm oil, palm kernel oil, hydrogenated palm oil, Japan wax kernel oil, hydrogenated oil, Japan wax, hydrogenated castor oil, etc. Examples of semi-solid oils include shea butter, partially hydrogenated coconut oil, partially hydrogenated jojoba oil, etc.

[0032] The cosmetic of the present invention may further contain a polyhydric alcohol. Examples of polyhydric alcohols include glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol, and polybutylene glycol. Among these, dipropylene glycol and 1,3-butylene glycol are preferred. Polyhydric alcohols can be used alone or in combination. While not limited thereto, the content of polyhydric alcohols is preferably 1 to 30% by mass, more preferably 2 to 25% by mass, and even more preferably 5 to 25% by mass, relative to the total amount of the cosmetic.

[0033] The cosmetic preparation of the present invention may further contain a surfactant. The surfactant is not particularly limited, and anionic surfactants, cationic surfactants, amphoteric surfactants, or nonionic surfactants can be used, but it is preferable to use nonionic surfactants.

[0034] The nonionic surfactant is not particularly limited as long as it is one commonly used in cosmetics. Examples of nonionic surfactants include glycerin or polyglycerin fatty acid esters, propylene glycol fatty acid esters, polyoxyethylene (POE) sorbitan fatty acid esters, POE sorbit fatty acid esters, POE glycerin fatty acid esters, POE fatty acid esters, POE alkyl ethers, POE-polyoxypropylene (POP) alkyl ethers, POE castor oil or POE hydrogenated castor oil, alkanolamides, POE propylene glycol fatty acid esters, POE alkylamines, POE fatty acid amides, POE-modified silicones, and POE-POP-modified silicones. These surfactants can be used alone or in combination of two or more.

[0035] Among these, polyoxyethylene hydrogenated castor oil is preferred, for example, PEG-60 hydrogenated castor oil, PEG-100 hydrogenated castor oil, etc. The surfactant content is preferably 0.01 to 5% by mass, and more preferably 0.01 to 3% by mass, based on the total amount of the cosmetic.

[0036] In addition to the above-mentioned components, the cosmetic of the present invention can contain optional components typically used in cosmetics and pharmaceuticals. Optional components include, for example, surfactants, moisturizers, lower alcohols, sequestering agents, neutralizing agents, pH adjusters, antioxidants, preservatives, drugs, UV absorbers, powder components, fragrances, etc. As long as the effects of the present invention are achieved, one or more optional components can be contained in the cosmetic.

[0037] The formulation of the cosmetic according to the present invention is not particularly limited, but is preferably an oil-in-water emulsion cosmetic. In an oil-in-water emulsion cosmetic, the aqueous phase comes into contact with the skin first, providing a moisturizing feel to the skin and enabling the effects of the present invention to be more clearly felt.

[0038] Examples of cosmetics according to the present invention include skin care cosmetics (e.g., lotion, emulsion, cream, serum, pack, mask, etc.), makeup cosmetics (e.g., foundation, makeup base, etc.), skin cleansers (e.g., face wash, makeup remover, etc.), sunscreen cosmetics, etc. Note that these forms are merely examples, and the cosmetics according to the present invention are not limited to these forms. The cosmetic composition according to the present invention can be produced by a conventional method. [Example]

[0039] The present invention will be described in detail based on the following examples, but the present invention is not limited to these examples. Unless otherwise specified, the contents are expressed in mass % relative to the total amount.

[0040] [Examples 1 to 6 and Comparative Examples 1 to 3] Oil-in-water emulsion cosmetics of the Reference Example, Examples 1 to 6, and Comparative Examples 1 to 3 were prepared according to the formulations shown in Table 1. [Table 1]

[0041] [Usability rating 1: familiarity] The cosmetics prepared above were applied to the skin by a panel of 10 experts, and the ease of use after application was evaluated according to the following criteria. The results are shown in Table 1. A: More than 8 people rated it as being familiar. B: 5 to 7 people rated it as being familiar. C: 3-4 people rated it as being familiar. D: Two or fewer people rated it as being familiar.

[0042] [Usability rating 2: Spreadability] The cosmetics prepared above were applied to the skin by a panel of 10 experts, and the ease of use during application was evaluated according to the following criteria. The results are shown in Table 1. A: More than 8 people rated it as having good stretchability. B: 5 to 7 people rated it as having good stretchability. C: 3 to 4 people rated it as having good stretchability. D: Two or fewer people rated it as having good stretch.

[0043] In Comparative Example 1, ascorbic acid 2-glucoside, a salt-type agent, was used instead of component (A). Component (A) was omitted in Comparative Example 2, and component (B) was omitted in Comparative Example 3. Although not shown in Table 1, the Reference Example, Examples 1 to 6, and Comparative Examples 1 to 3 all had a fresh and refreshing feel when used.

Claims

1. As the component (A), (a-1) A pyrimidylpyrazole compound represented by formula (1) or a salt thereof, or (a-2) a cyclic carboxamide derivative represented by formula (2) or a salt thereof, At least one of the following: (B) a water-absorbing polymer having a carboxyl group; (C) agar, and (D) water; A cosmetic comprising: 【Chemistry 1】 (In the formula, R １ , R ３ , R ４ and R ６ are each independently C １－３ is an alkyl group, and R ２ and R ５ are each independently a hydrogen atom or C １－３ alkyl group) 【Chemistry 2】 (In the formula, R ２１ represents a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom, X is -CH ２ - or -NR-, where R is a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom; and n is an integer from 1 to 3.

2. R ２ and R ５ The cosmetic according to claim 1, wherein is a hydrogen atom.

3. R １ , R ３ , R ４ and R ６ The cosmetic preparation according to claim 1 or 2, wherein is a methyl group.

4. R ２１ is a hydroxyalkyl group having 1 to 3 carbon atoms, X is -CH ２ - or -NH-, and The cosmetic according to claim 1 or 2, wherein n is 1.

5. 3. The cosmetic preparation according to claim 1, wherein the component (a-1) is dimethylpyrazolyldimethylpyrimidine hydrochloride.

6. 3. The cosmetic preparation according to claim 1, wherein the component (a-2) is 1-(2-hydroxyethyl)-2-imidazolidinone.

7. 3. The cosmetic according to claim 1, wherein the content of component (a-1) is 0.01 to 1.5% by mass relative to the total amount of the cosmetic.

8. 3. The cosmetic according to claim 1, wherein the content of component (a-2) is 0.1 to 5% by mass relative to the total amount of the cosmetic.

9. 3. The cosmetic according to claim 1, wherein the water absorption capacity of component (B) is 10 to 1,000 times its own weight.

10. 3. The cosmetic preparation according to claim 1, wherein component (B) is carbomer Na.

11. 3. The cosmetic according to claim 1, wherein the content of component (B) is 0.01 to 2% by mass relative to the total amount of the cosmetic.

12. 3. The cosmetic according to claim 1, wherein the content of component (C) is 0.1 to 5% by mass relative to the total amount of the cosmetic.

13. The cosmetic preparation according to claim 1 or 2, further comprising (E) an oil component.

14. The cosmetic according to claim 1 or 2, which is an oil-in-water emulsion cosmetic.

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