Krill oil-containing composition

Abstract

To provide a composition capable of softening a peculiar smell of krill oil and reducing an unpleasant feeling in ingestion.SOLUTION: A composition comprising krill oil and at least one selected from the group consisting of caramel, tea extract, and Boswellia serrata extract.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a krill oil-containing composition in which the unpleasant odor of krill oil is reduced. [Background technology]

[0002] In general, supplements such as soft capsules containing health food ingredients can provide more stable physiological activity through continuous daily intake. Soft capsules and other supplements help to make daily intake easier by reducing the odor and taste of the ingredients they contain, but in the case of ingredients with a strong odor, the odor may not be suppressed by formulation alone.

[0003] For example, krill oil, extracted from krill, is sold as a supplement due to its various physiological activities. However, krill oil has a unique odor that some people find unpleasant due to trace amounts of trimethylamine and ammonia contained in it, in addition to the inherent krill odor. Furthermore, krill oil's unique odor can sometimes be further intensified due to chemical changes such as oxidation over time. For this reason, technologies to prevent oxidation, which is one of the causes of krill oil's unique odor, and technologies to mask the unpleasant odor of krill oil are being investigated (see, for example, Patent Documents 1 to 8). [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2014-125579 [Patent Document 2] Japanese Patent Application Laid-Open No. 2015-062398 [Patent Document 3] Japanese Patent Application Laid-Open No. 2015-159801 [Patent Document 4] Special Publication No. 2015-517318 [Patent Document 5] Japanese Patent Application Laid-Open No. 2016-074628 [Patent Document 6] Japanese Patent Application Laid-Open No. 2016-108244 [Patent Document 7] Japanese Patent Application Laid-Open No. 2016-108245 [Patent Document 8] Japanese Patent Application Publication No. 2018-104372 Summary of the Invention [Problem to be solved by the invention]

[0005] To ensure that supplements containing krill oil, which has various physiological activities, can be taken daily without discomfort, it is essential to mitigate the distinctive odor of krill oil. In this regard, existing technologies have room for improvement, and further technologies to mitigate the distinctive odor of krill oil are needed. While ginger extract and tea extract are known to have deodorizing effects against trimethylamine and ammonia contained in fish oil, they have not been known to reduce the unpleasant odor of krill oil, which is not found in fish oil. Furthermore, caramel and Boswellia serrata extract have distinctive odors and are used for various purposes. Caramel can be used, for example, as a coloring agent. Boswellia serrata extract can be used, for example, as an anti-inflammatory agent. However, caramel and Boswellia serrata extract are not typically used for odor reduction, and there is no mention of them in the above-mentioned Patent Documents 1 to 8.

[0006] Therefore, the present invention provides a composition that can soften the distinctive odor of krill oil and reduce the unpleasant feeling when ingested. [Means for solving the problem]

[0007] The present inventors have discovered that the above problems can be solved by creating a composition containing krill oil and a specific odor-mitigating substance. That is, the present invention is as follows.

[0008] [1] Contains krill oil and an odor-reducing substance; The odor-mitigating substance is at least one selected from the group consisting of ginger extract, caramel, tea extract, and Boswellia serrata extract. composition. [2] The composition according to [1] above, wherein the odor-mitigating substance is contained in an amount of 0.5% by mass or more relative to the krill oil, when the total amount of krill oil contained is taken as 100% by mass. [3] The composition according to [1] or [2] above, wherein the ginger extract is contained in an amount of 0.5% by mass or more relative to the krill oil, when the total amount of krill oil contained is taken as 100% by mass. [4] The composition according to any one of [1] to [3] above, wherein the ginger extract contains 0.01% by mass or more of shogaol. [5] The composition according to any one of [1] to [4] above, wherein the caramel is contained in an amount of more than 0.5% by mass relative to the krill oil, when the total amount of krill oil contained is taken as 100% by mass. [6] The composition according to any one of [1] to [5] above, wherein the tea extract is contained in an amount of 4% by mass or more relative to the krill oil, when the total amount of the krill oil contained is taken as 100% by mass. [7] The composition according to any one of [1] to [6] above, wherein the tea extract is an oil containing tea catechins. [8] The composition according to any one of [1] to [7] above, wherein the Boswellia serrata extract is contained in an amount of 0.5% by mass or more and less than 20% by mass relative to the total amount of krill oil contained, taken as 100% by mass. [9] A capsule comprising the composition according to any one of [1] to [8] above and a shell that covers the composition. [Effects of the Invention]

[0009] According to the present invention, a composition can be provided that can reduce the distinctive odor of krill oil and reduce the unpleasant feeling when ingested. DETAILED DESCRIPTION OF THE INVENTION

[0010] The present invention will be described below based on an example of an embodiment, but the present invention is not limited to the following description. In addition, although preferred embodiments are shown in this specification, a combination of two or more of the individual preferred embodiments is also a preferred embodiment. When a numerical range (for example, a range of content) is described in stages, the lower limit and upper limit can be selectively combined to form a preferred embodiment. In this specification, when a numerical range is stated as "XX to YY", it means "XX or more and YY or less."

[0011] The present embodiment provides a composition (hereinafter also simply referred to as "composition") comprising krill oil and an odor-mitigating substance. The odor-mitigating substance is at least one selected from the group consisting of ginger extract, caramel, tea extract, and Boswellia serrata extract. By mixing krill oil with odor-mitigating substances, such as plant-derived substances, it is possible to reduce the unpleasant feeling experienced when ingesting krill oil while maintaining the functionality of the oil. This is thought to be because the odor-mitigating substances remove or mitigate the distinctive odor of krill oil through chemical action or other means. Based on the above considerations, the inventors discovered that a formulation containing krill oil and specific odor-mitigating substances can solve the problem of reducing the unpleasant sensation experienced when ingesting krill oil, and thus arrived at the present invention.

[0012] The composition of this embodiment preferably contains at least 0.5% by weight, more preferably at least 1% by weight, of an odor-mitigating substance relative to the krill oil, assuming the total amount of krill oil contained as 100% by weight. A content of at least 0.5% by weight of the odor-mitigating substance further enhances the mitigation of the krill oil odor. When the composition of this embodiment contains two or more odor-mitigating substances, the content of the odor-mitigating substances refers to the total content of the odor-mitigating substances.

[0013] Specific examples of the present invention include a composition containing krill oil and ginger extract, a composition containing krill oil and caramel, a composition containing krill oil and tea extract, and a composition containing krill oil and Boswellia serrata extract. These specific compositions are described below, but the present invention is not limited to these specific compositions.

[0014] In one embodiment of the present invention, the composition may or may not contain additives other than the krill oil and odor-mitigating substances described above, provided that the effects of the present invention are not impaired.

[0015] [Krill oil] Krill oil is a marine-derived oil extracted from krill, containing omega-3 fatty acids, phospholipids, and astaxanthin. It is widely used as a supplement worldwide. Because the omega-3 fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are largely bound to phospholipids, it is said to be highly absorbable by the human body. EPA and DHA are known to be effective in suppressing inflammation, such as arthritis, lowering triglycerides, promoting weight loss, treating premenstrual syndrome and dysmenorrhea, and improving brain function.

[0016] In this embodiment, commercially available krill oil can be used, such as Superba 2 (registered trademark, manufactured by Aker Biomarine).

[0017] The krill oil content in the composition is preferably 50% by mass or more, more preferably 60% by mass or more, even more preferably 70% by mass or more, and can be 80% by mass or more. The krill oil content in the composition is preferably 99% by mass or less, more preferably 98% by mass or less. When the krill oil content in the composition is within the above range, it is expected that the functions of krill oil can be effectively exhibited.

[0018] [Ginger extract] In this embodiment, the composition contains krill oil and ginger extract. Ginger is a perennial plant of the Zingiberaceae family native to tropical Asia and has long been widely used as a spice around the world. Functional components contained in ginger extracts extracted by known methods include shogaol and gingerol, which are pungent components and are known to have blood flow-improving, vasodilatory, and anti-inflammatory effects.

[0019] In this embodiment, the term "ginger extract" refers to an extract obtained by extracting from the rhizomes of ginger (Zingiber officinale) belonging to the genus Zingiber. The variety of ginger is not particularly limited, and examples include large gingers such as Otafuku ginger and Omi ginger, medium gingers such as Sanshu ginger and yellow ginger, and small gingers such as Kintoki ginger and Yanaka ginger.

[0020] Ginger can be extracted by known methods, such as steam distillation, solvent extraction, supercritical extraction, and carbon dioxide extraction. The temperature conditions and solvent used during extraction can be selected appropriately. In addition, ginger can be used in the form of pulverized material, squeezed juice, or pomace to increase extraction efficiency. Components contained in the ginger extract include shogaol and gingerol. From the viewpoint of further mitigating the odor of krill oil, it is preferable that the ginger extract contains shogaol. Most of the components contained in raw ginger are gingerol, and only trace amounts of shogaol are contained. Therefore, gingerol may be converted to shogaol by heating or the like, and the shogaol content in the ginger extract may be adjusted. The ginger extract preferably contains 0.01% by mass or more of shogaol, more preferably 0.01 to 5% by mass, and even more preferably 0.5 to 5% by mass. When the ginger extract contains 0.01% by mass or more of shogaol, the odor of krill oil can be further alleviated.

[0021] Commercially available ginger extracts can also be used, such as SUN Ginger (manufactured by Sunsho Pharmaceutical Co., Ltd.), which contains a high amount of shogaol.

[0022] <Content> To further mitigate the odor of krill oil, the composition preferably contains ginger extract in an amount of 0.5% by mass or more, more preferably 1% by mass or more, and even more preferably 2% by mass or more, based on the total amount of krill oil contained, taken as 100% by mass. The upper limit of the ginger extract content is not limited as long as it does not impair the effects of the present invention. When the composition is used as a product such as a supplement, the ginger extract content is preferably 50% by mass or less, more preferably 20% by mass or less, based on the total amount of krill oil contained, taken as 100% by mass, in order to more effectively exert the functions of krill oil.

[0023] [Caramel] In this embodiment, the composition contains krill oil and caramel. Caramel is a food additive used as a coloring agent, and is a brown paste with a slight, distinctive odor.

[0024] In the present embodiment, caramel can be produced by a known method. For example, caramel can be obtained by gently heating water and sugars and boiling them down until they become a brown paste. The heating can be carried out while adjusting the balance of sweetness, bitterness, viscosity, etc., of the caramel as desired. Examples of sugars include monosaccharides, disaccharides, oligosaccharides, polysaccharides, honey, maple sugar, brown sugar, etc. These may be used alone or in combination of two or more.

[0025] Commercially available caramel products can also be used, such as Homo Caramel HC-30 (manufactured by Ikeda Tohka Kogyo Co., Ltd.), which is an emulsified caramel.

[0026] <Content> To further mitigate the odor of krill oil, the composition preferably contains more than 0.5% by mass, more preferably 1% by mass or more, and even more preferably 2% by mass or more of caramel relative to the krill oil, when the total amount of krill oil contained is taken as 100% by mass. The upper limit of the caramel content is not limited as long as it does not impair the effects of the present invention. When the composition is used as a product such as a supplement, the caramel content is preferably 20% by mass or less, more preferably 5% by mass or less, relative to the krill oil, when the total amount of krill oil contained is taken as 100% by mass, in order to more effectively exert the functions of the krill oil.

[0027] [Tea extract] In this embodiment, the composition contains krill oil and tea extract. In this embodiment, the "tea extract" refers to an oil extracted from green tea leaves, and contains a large amount of tea catechins, which are known to have antioxidant, antiviral, and LDL cholesterol-lowering effects. Tea catechins are a type of polyphenol, and include epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, and the like. The tea extract preferably contains 0.01% by mass or more of tea catechins, more preferably 0.01 to 20% by mass, and even more preferably 0.1 to 10% by mass. When the tea extract contains 0.01% by mass or more of tea catechins, the odor of krill oil is more easily alleviated.

[0028] In this embodiment, the tea extract is preferably an oil containing tea catechins. The oily nature of the tea extract provides excellent mixing and dispersibility with krill oil, further enhancing the odor mitigation of krill oil. Therefore, even if the tea extract contains only a small amount of tea catechins, the oily tea extract can be easily dispersed when mixed with krill oil, thereby providing excellent odor mitigation of krill oil.

[0029] In this embodiment, the tea extract can be produced by a known method. For example, the tea extract can be produced by drying green tea leaves and subjecting them to heated water treatment, steam distillation, or immersing them in alcohol or a mixture of alcohol and water to extract tea catechin-rich components in the form of a solution. Furthermore, to increase the extraction efficiency, the green tea leaves can be used in powdered or shredded form.

[0030] Commercially available tea extracts can also be used, such as Coco Green GRSC (manufactured by Pure Green Co., Ltd.), an oil containing all the components of green tea.

[0031] <Content> To further mitigate the odor of krill oil, the content of tea extract relative to the krill oil is preferably 4% by mass or more, more preferably 5% by mass or more, when the total amount of krill oil contained in the composition is taken as 100% by mass. The content of tea extract in the composition within the above range can further mitigate the odor of krill oil. Furthermore, the upper limit of the caramel content is not limited as long as it does not impair the effects of the present invention. When the composition is used as a product such as a supplement, to more effectively demonstrate the functions of krill oil, the content of tea extract relative to the krill oil is preferably 50% by mass or less, more preferably 20% by mass or less, when the total amount of krill oil contained is taken as 100% by mass.

[0032] [Boswellia serrata extract] In this embodiment, the composition contains krill oil and Boswellia serrata extract. Boswellia serrata extract is an extract extracted from plants of the Boswellia genus in the Burseraceae family, and is known for its relaxing effects, wrinkle prevention, and relief of joint pain symptoms.

[0033] Boswellia serrata extract contains terpenes such as boswellic acid, a triterpene with five hexagonal rings and a carboxyl group. In this embodiment, the Boswellia serrata extract may contain one or more boswellic acids. Furthermore, among the boswellic acids, the Boswellia serrata extract preferably contains β-boswellic acid, from the viewpoint of further reducing the odor of krill oil. The content of β-boswellic acid in the Boswellia serrata extract is preferably 60 to 95% by mass.

[0034] Alternatively, commercially available Boswellia serrata extracts can be used, such as Boswellia Powder K (manufactured by Nippon Shinyaku Co., Ltd.), a hydroalcoholic extract.

[0035] <Content> To further mitigate the odor of krill oil, the content of Boswellia serrata extract relative to the krill oil in the composition is preferably 0.5% by mass or more, more preferably 1% by mass or more, and even more preferably 3% by mass or more, when the total amount of krill oil contained in the composition is taken as 100% by mass. Furthermore, to balance the odors of the krill oil and Boswellia serrata extract and further mitigate the odor of krill oil, the content of Boswellia serrata extract is preferably less than 20% by mass, more preferably 15% by mass or less.

[0036] [Preparation of Composition] In this embodiment, the composition can be prepared by combining the krill oil and the odor mitigating substance by known methods. The total amount of krill oil and odor mitigating substance in the composition is preferably 80 to 100% by mass, more preferably 90 to 100% by mass.

[0037] [Application] In this embodiment, the composition can be applied to foods, pharmaceuticals, quasi-drugs, foods for specified health uses, foods with functional claims, foods with nutrient functions, nutritional supplements, supplements, health foods, veterinary pharmaceuticals, veterinary quasi-drugs, functional foods for animals, veterinary nutritional supplements, veterinary supplements, or health foods for animals.

[0038] In this embodiment, the composition may be used alone, or, if necessary, may be used by adding excipients, binders, disintegrants, lubricants, stabilizers, surfactants, solubilizers, reducing agents, buffers, adsorbents, fluidizing agents, antistatic agents, antioxidants, sweeteners, flavoring agents, refreshing agents, light-blocking agents, flavoring agents, fragrances, aromas, coating agents, plasticizers, and the like that are commonly used in the above-mentioned products.

[0039] In the present embodiment, the product form of the composition is not particularly limited, and examples thereof include liquid (liquid), syrup (syrup), powder (granules, fine granules), tablet (tablet, tablet), capsule (capsule), soft capsule (soft capsule), solid, semi-liquid (jelly), cream, paste, etc.

[0040] <capsule> One preferred aspect of this embodiment is a capsule comprising the composition and a shell enclosing the composition. The capsules may be in any form as long as they do not impair the effects of the present invention, and may be, for example, hard or soft capsules. These capsules can be produced by conventional methods, and there are no particular limitations on their shape, size, or coating formulation. In this embodiment, the shell that covers the composition can be appropriately determined depending on the purpose and use. Examples of raw materials for the shell include gelatin, agar, carrageenan, starch, alginic acid, pullulan, etc., and thickening polysaccharides such as HPMC (hydroxypropyl methylcellulose) may also be used. [Example]

[0041] The present invention will be specifically explained below with reference to examples and comparative examples, but the present invention is not limited to these.

[0042] [How to evaluate discomfort] The degree of unpleasant odor was defined as "unpleasantness," and 10 subjects who found the unique odor of krill oil unpleasant evaluated the degree of unpleasantness of the composition of the example and the krill oil alone of the comparative example according to the criteria listed in Table 1. In addition, the standard for the level of discomfort that can be tolerated when taking supplements on a daily basis was set at -1.8.

[0043] [Table 1]

[0044] In the examples and comparative examples, the krill oil used was "Superba 2" (manufactured by Aker Biomarine). In the examples, the proportion of the odor mitigating substance added when the total amount of krill oil is taken as 100% by mass is referred to as the "additional blending rate (% by mass)." In addition, in Tables 2 to 5, "%" means "% by mass."

[0045] <Comparative Example> For the comparative example, 10g of krill oil was placed in a sealed glass bottle and stored in a 40°C incubator for one week. The unpleasantness of the odor was evaluated according to the above-mentioned evaluation method. The unpleasantness score for the comparative example was -1.9.

[0046] Example 1 Compositions were prepared by gradually varying the amount of ginger extract added to krill oil from 0.5 to 20% by mass. 10 g of each composition was transferred into a glass bottle and stored in a sealed container at 40°C for one week. These were designated "Mixture 1." Table 2 shows the results of the evaluation of discomfort for the above-mentioned "Mixture 1 Group." The degree of discomfort is shown as the average value for 10 subjects. The ginger extract used was "SUN Ginger" (manufactured by Sunsho Pharmaceutical Co., Ltd.). "SUN Ginger" contains 0.5% by mass of shogaol as specified.

[0047] [Table 2]

[0048] In the krill oil and ginger extract "Mixture Group 1," when the ginger extract was added to the krill oil at a ratio of 0.5% by mass or more, the discomfort rating exceeded -1.8, the tolerable standard. Even at 20% by mass of ginger extract, discomfort was sufficiently reduced. Based on these trends, it is expected that discomfort can be reduced even if the ginger extract is added at 20% by mass or more. However, because the goal was to ingest krill oil as a supplement without discomfort, no additional tests beyond 20% by mass were conducted.

[0049] Gingerol and gingerol contained in ginger extract are known to have anti-inflammatory effects, so when taken together with krill oil, additive and synergistic anti-inflammatory effects on knee joints and other joints can be expected.

[0050] <Example 2> The composition was prepared by gradually varying the amount of caramel added to krill oil from 0.5 to 20% by mass. 10 g of each composition was transferred into a glass bottle and stored in a sealed container at 40°C for one week. This was designated "Mixture Group 2." Table 3 shows the results of the evaluation of discomfort for the above-mentioned "Mixture 2 Group." The degree of discomfort is shown as the average value for 10 subjects. For the caramel, "Homo Caramel HC-30" (manufactured by Ikeda Tohka Kogyo Co., Ltd.) was used. "Homo Caramel HC-30" has a standard caramel content of 25% by mass. The above additional blending ratio is based on the amount of caramel in "Homo Caramel HC-30."

[0051] [Table 3]

[0052] In the krill oil and caramel "mixture group 2," when the caramel content was 1% or more by mass, the discomfort rating exceeded -1.8, the tolerable standard. Even at 20% by mass, the discomfort was sufficiently reduced. Based on these trends, it is expected that discomfort can be reduced even if the caramel content is increased by more than 20% by mass. However, because the goal was to ingest krill oil as a supplement without discomfort, no additional testing beyond 20% by mass was conducted.

[0053] Caramel is also used as a coloring agent for the shell of soft capsules, and by incorporating it into the shell rather than mixing it directly with krill oil, it is expected that the unpleasant taste of krill oil will be reduced.

[0054] Example 3 The compositions were prepared by gradually varying the amount of tea extract added to krill oil from 0.5 to 20% by mass. 10 g of each composition was transferred into a glass bottle and stored in a sealed container at 40°C for one week. These were designated "Mixture Group 3." Table 4 shows the results of the evaluation of discomfort for the above-mentioned "Mixture 3 Group." The degree of discomfort is shown as the average value for 10 subjects. The tea extract used was "Coco Green GRSC" (manufactured by Pure Green Co., Ltd.). "Coco Green GRSC" contains catechins at a standard value of 50 mg or more per 100 g.

[0055] [Table 4]

[0056] In the krill oil and tea extract "Mixture Group 3," the tolerable discomfort level of -1.8 was reached when the tea extract was added to the krill oil at a rate of 4% by mass or more. At rates of 10% and 20% by mass, the level of discomfort tended to increase slightly compared to the 5% rate. While the increased tea extract appears to have disrupted the balance between the odors of the krill oil and tea extract, the tolerable discomfort level of -1.8 was maintained at both 10% and 20% by mass.

[0057] The tea extract has antioxidant properties that improve the storage stability of krill oil, and in humans, it has the effect of lowering LDL cholesterol, so taking it together with krill oil is expected to be effective in improving vascular health.

[0058] Example 4 Compositions were prepared by gradually varying the amount of Boswellia serrata extract added to krill oil from 0.5 to 20% by mass. 10g of each composition was transferred into glass bottles and stored in a sealed container at 40°C for one week. These were designated "Mixture Group 4." Table 5 shows the results of the evaluation of discomfort for the above-mentioned "Mixture 4 Group." The degree of discomfort is shown as the average value for 10 subjects. The Boswellia serrata extract used was "Boswellia Powder K" (manufactured by Nippon Shinyaku Co., Ltd.). "Boswellia Powder K" contains 80% by mass of boswellic acid (mainly β-boswellic acid) as specified.

[0059] [Table 5]

[0060] In the "mixture 4" of krill oil and Boswellia serrata extract, the unpleasantness rating exceeded -1.8, the tolerable standard, when the ratio of Boswellia serrata extract to krill oil was 0.5% by mass or more. However, unpleasantness tended to increase when the ratio was 20% by mass. It is thought that increasing the Boswellia serrata extract to 20% by mass disrupted the balance of the odors of the krill oil and Boswellia serrata extract, increasing unpleasantness.

[0061] Boswellia serrata extract is known to have effects such as alleviating joint pain symptoms, so taking it together with krill oil can be expected to have additive and synergistic anti-inflammatory effects on knee joints and other joints.

[0062] <Consideration> The results of the above studies confirmed that adding at least one selected from ginger extract, caramel, tea extract, and Boswellia serrata extract to krill oil reduces the distinctive odor of krill oil and reduces the unpleasant feeling experienced when ingesting it, compared to krill oil alone. It has been found that the composition of this embodiment reduces the unpleasant odor inherent in krill oil by incorporating specific odor-mitigating substances into the krill oil. [Industrial Applicability]

[0063] The composition of this embodiment can mitigate the odor characteristic of krill oil and reduce discomfort when ingested. Therefore, the composition of this embodiment can be used in the form of capsules or other products, such as foods, pharmaceuticals, quasi-drugs, foods for specified health uses, foods with functional claims, foods with nutrient functions, dietary supplements, supplements, health foods, veterinary drugs, veterinary quasi-drugs, functional foods for animals, nutritional supplements for animals, veterinary supplements, or health foods.

Claims

1. A composition comprising krill oil and at least one selected from the group consisting of caramel, tea extract, and Boswellia serrata extract.

2. The composition according to claim 1, wherein the caramel is contained in an amount of more than 0.5% by mass relative to the krill oil, when the total amount of krill oil contained is taken as 100% by mass.

3. 2. The composition according to claim 1, wherein the tea extract is contained in an amount of 4% by mass or more relative to the krill oil, when the total amount of the krill oil contained is taken as 100% by mass.

4. The composition according to claim 1 , wherein the tea extract is an oil containing tea catechins.

5. 2. The composition according to claim 1, wherein the Boswellia serrata extract is contained in an amount of 0.5% by mass or more and less than 20% by mass relative to the total amount of krill oil contained, taken as 100% by mass.

6. The composition according to any one of claims 1 to 5, a shell covering the composition; and A capsule comprising:

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