Oral composition

Abstract

To provide a composition for the oral cavity capable of exhibiting a plurality of effects by an enzyme, or a composition for the oral cavity capable of highly exhibiting a specific effect by the enzyme.SOLUTION: The component (A) is an oral composition containing two or more kinds of enzymes.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an oral composition. [Background technology]

[0002] Conventionally, various enzymes have been blended into oral compositions from the viewpoints of preventing dental caries and inhibiting their progression, preventing bad breath, and further improving the aesthetic appearance of teeth (Patent Documents 1 and 2). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Publication No. 2022-094006 [Patent Document 2] Japanese Patent Application Publication No. 2024-093532 Summary of the Invention [Problem to be solved by the invention]

[0004] In an oral composition containing an enzyme, there are cases where it is desired to exert multiple effects derived from the enzyme, or to exert a specific effect derived from the enzyme at a high level.

[0005] An object of the present invention is to provide an oral composition that can exert multiple effects derived from enzymes, or an oral composition that can exert a specific effect derived from enzymes to a high degree. [Means for solving the problem]

[0006] The present invention provides an oral composition containing component (A): two or more types of enzymes. [Effects of the Invention]

[0007] According to the present invention, it is possible to provide an oral composition that can exert multiple effects derived from enzymes, or an oral composition that can exert a specific effect derived from enzymes to a high degree. DETAILED DESCRIPTION OF THE INVENTION

[0008] 1. Composition of oral composition The oral composition contains component (A) and, if necessary, optional components.

[0009] <Component (A)> Component (A) is a component containing two or more enzymes. By including component (A), the oral composition can be endowed with multiple enzyme-derived effects. Furthermore, specific enzyme-derived effects can be more effectively exhibited.

[0010] The enzymes include polysaccharide-degrading enzymes and protease enzymes.

[0011] Polysaccharide-degrading enzymes are enzymes that hydrolyze and cleave the glycosidic bonds of polysaccharides to produce the constituent monosaccharides, oligosaccharides, or derivatives thereof. Examples of polysaccharides include dextran, mucin, cellulose, starch, chitin, agarose, carrageenan, heparin, alginic acid, hyaluronic acid, pectin, xylan, glucomannan, levan, glycogen, β-1,6-glucan, β-1,3-glucan, β-1,2-glucan, α-1,3-glucan, and α-1,2-glucan. Among these, polysaccharides involved in oral diseases (e.g., dental caries) are preferred, and polysaccharides contained in oral biofilms (e.g., dental plaque), such as dextran and mucin, are more preferred. Examples of polysaccharide-degrading enzymes include dextranase, mutanase, α-amylase, β-amylase, pullulanase, glucoamylase, α-glucosidase, isoamylase, cellulase (including β-glucanase), hemicellulase, and xylanase. The polysaccharide-degrading enzyme is preferably dextranase or mutanase, more preferably dextranase. This degrades polysaccharides such as dextran and mutan contained in oral biofilms (e.g., dental plaque), thereby inhibiting and preventing the progression of dental caries in the oral cavity. The origin of the enzyme is not particularly limited, and it may be naturally derived from microorganisms, plants, animals, etc., or may be artificially prepared by genetic recombination, chemical synthesis, etc. When the polysaccharide-degrading enzyme is dextranase, it may be dextranase derived from bacteria capable of producing dextranase (e.g., bacteria belonging to the genera Chaetomium, Penicillium, Aspergillus, Spicaria, Lactobacillus, and Cellvibrio). One type of polysaccharide-degrading enzyme may be used alone, or two or more types may be used in combination.

[0012] Proteases are enzymes that catalyze the hydrolysis of peptide bonds in proteins. Proteases may be either endopeptidases or exopeptidases (aminopeptidases, carboxypeptidases), with endopeptidases being preferred. Examples of endoproteases include cysteine ​​proteases such as papain, bromelain, and actinidin, and serine proteases such as nattokinase. Cysteine ​​proteases are preferred, with papain, bromelain, and actinidin being more preferred, and papain being even more preferred. This allows the enzyme to decompose proteins present in oral biofilms (e.g., tongue coating) and exhibit oral biofilm removal effects. The origin of the enzyme is not particularly limited, and it may be naturally derived from microorganisms, plants, animals, etc., or artificially prepared by genetic recombination, chemical synthesis, etc. Papain can be derived from papaya (Carica papaya) fruit, actinidin from kiwi (Actinidia deliciosa) fruit, bromelain from pineapple (Ananas comosus) fruit or rhizome, and nattokinase from Bacillus natto. Examples of protease include proteases produced by bacteria belonging to the genera Aspergillus and Bacillus. Proteases may be used singly or in combination.

[0013] Furthermore, as an enzyme other than polysaccharide-degrading enzymes and proteases, for example, lipase can be used.

[0014] The two or more enzymes that component (A) may contain may include a combination of a polysaccharidase and a protease, may contain only two or more of the polysaccharidases described above, or may contain only two or more of the proteases described above. When component (A) contains a combination of a polysaccharidase and a protease, it can be an oral composition that can exert multiple effects, including effects due to the degradation of polysaccharides (e.g., the effect of decomposing and removing dental plaque) and effects due to the degradation of proteins (e.g., the effect of removing tongue coating). On the other hand, when component (A) contains only two or more polysaccharidases, it can exert a stronger effect due to the degradation of polysaccharides. Furthermore, when component (A) contains only two or more proteases, it can exert a stronger effect due to the degradation of proteins.

[0015] In particular, component (A) preferably contains a combination of a polysaccharidase and a protease, and more preferably contains dextranase as one of the enzymes. When component (A) contains a combination of a polysaccharidase and a protease, it may contain one type of polysaccharidase and one type of protease, or it may contain two or more types of at least one of a polysaccharidase and a protease.

[0016] The number (types) of enzymes that can be contained in component (A) may be two or more, preferably 2 to 10 (types), and more preferably 2 to 6 (types).

[0017] The content of the enzyme in component (A) in terms of enzymatic activity is not particularly limited and can be selected appropriately depending on the type of enzyme. Examples are as follows: The content of dextranase in the composition is preferably 0.01 to 100 U / g in terms of enzyme activity (per 1 g of enzyme, the same applies hereinafter). The content of lipase is preferably 0.01 to 20 U / g. The content of xylanase is preferably 3 to 50 U / g. The content of amylase is preferably 0.2 to 20 U / g. The content of glucoamylase is preferably 0.01 to 10 U / g. The content of papain is preferably 1 to 20 U / g. The content of bromelain is preferably 5 to 20 U / g. The content of cellulase is preferably 1 to 20 U / g.

[0018] The content (% by mass) of component (A) relative to the total amount (100% by mass) of the oral cavity composition can be appropriately selected depending on the type and activity of the enzyme.

[0019] <Optional ingredients> The oral composition may contain optional components other than component (A) as needed. Examples of optional ingredients include abrasives, surfactants, wetting agents, binders, flavorings, solvents, sweeteners, medicinal ingredients, oily ingredients, preservatives, pH adjusters, and colorants (pigments). The optional ingredients may be used alone or in combination of two or more.

[0020] In this specification, unless otherwise specified, the content of each component is based on the amount of each component charged when producing the oral composition, and unless otherwise specified, refers to mass % relative to 100 mass % of the total amount of the oral composition.

[0021] -Abrasives- The abrasive may be either inorganic or organic. Examples of inorganic abrasives include silica-based abrasives (abrasive silica (anhydrous silicic acid)) such as precipitated silica, crystalline silica, amorphous silica, silica gel, aluminosilicate, zirconosilicate, and titanium-bonded silica; zeolites; calcium phosphate compounds such as anhydrous calcium hydrogen phosphate, calcium hydrogen phosphate dihydrate, dibasic calcium phosphate dihydrate or anhydrous calcium phosphate, monobasic calcium phosphate, tribasic calcium phosphate, and tetrabasic calcium phosphate; calcium carbonate-based abrasives such as light and heavy calcium carbonate; aluminum hydroxide, aluminum oxide (alumina), magnesium carbonate, tribasic magnesium phosphate, calcium sulfate, and zirconium silicate; apatite-based materials such as hydroxyapatite, fluoroapatite, and calcium-deficient apatite; titanium-based materials such as titanium oxide; and minerals such as bentonite. Examples of organic abrasives include polymethyl methacrylate and synthetic resin-based abrasives.

[0022] The abrasive silica is preferably abrasive particles having an average particle size of 1 to 40 μm, and the BET specific surface area of ​​the abrasive silica is preferably 80 to 250 square meters per gram. Here, the average particle size of the abrasive silica is the volume-based median diameter (D50) measured by laser diffraction / scattering method.

[0023] There are no particular limitations on the RDA value (Radioactive Dentine Abrasion Values) of the abrasive, but it is preferably 50-200. The abrasive may be a granulated product. Examples of the granulated product include particles obtained by granulating a water-insoluble powder (e.g., silica gel, precipitated silica) into granules. For example, particles containing pigments such as Red No. 202, No. 205, Red No. 226, Orange No. 203, and Yellow No. 205 may be contained. When granulating into granules, any suitable binder known in the art may be used.

[0024] The abrasive may be used alone or in combination of two or more. The content of the abrasive is preferably 7 to 50 mass %, more preferably 10 to 30 mass %.

[0025] -Surfactants- Examples of surfactants include anionic surfactants, nonionic surfactants, amphoteric surfactants, and cationic surfactants.

[0026] Examples of anionic surfactants include alkyl sulfates, acylamino acid salts, acyltaurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfate, lauryl sulfoacetate, and polyoxyethylene alkyl sulfosuccinate. The alkyl and acyl groups may be linear or branched, saturated or unsaturated, and preferably have 10 to 20 carbon atoms, more preferably 12 to 18, and even more preferably 12 to 14. The average number of moles of ethylene oxide added in polyoxyethylene alkyl sulfosuccinate is preferably 1 to 9. The salt may be selected from pharmacologically acceptable salts. Examples of pharmacologically acceptable salts include base addition salts and amino acid salts. Specific examples include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts. Among these, inorganic base salts are preferred, alkali metal salts (for example, sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0027] Examples of alkyl sulfates include lauryl sulfate (e.g., sodium lauryl sulfate) and myristoyl sulfate. Examples of acylamino acid salts include acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; acyl glutamates such as lauroyl glutamate (e.g., sodium lauroyl glutamate), myristoyl glutamate and palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methyl glycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt and N-methyl-N-acylalanine salt; and acyl aspartates such as lauroyl aspartate. Examples of acyltaurine salts include lauroylmethyl taurine salt, N-methyl-N-acyltaurine salt, and N-cocoylmethyl taurine salt. Examples of α-olefin sulfonates include α-olefin sulfonates having 12 to 18 carbon atoms, such as tetradecene sulfonate (e.g., sodium tetradecene sulfonate). Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride sodium monosulfate and sodium lauryl sulfoacetate.

[0028] Examples of nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers (e.g., polyoxyethylene stearyl ether), polyoxyethylene-polyoxypropylene alkyl ethers, glycerin fatty acid esters, polyglycerin fatty acid esters (e.g., decaglycerin fatty acid ester), alkyl glucosides, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), fatty acid alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, sucrose fatty acid esters (e.g., sucrose stearate), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), polyoxyethylene polyoxypropylene copolymers, and polyoxyethylene polyoxypropylene fatty acid esters.

[0029] The average number of moles of ethylene oxide added to polyoxyethylene hydrogenated castor oil is preferably 5 to 100 moles, more preferably 5 to 60 moles. The number of carbon atoms in the alkyl chain of polyoxyethylene alkyl ether is preferably 10 to 26, and the average number of moles of ethylene oxide added is preferably 2 to 50 moles. The number of carbon atoms in the fatty acid of polyglycerin fatty acid ester is preferably 10 to 20. The average number of moles of ethylene oxide added to polyoxyethylene-polyoxypropylene alkyl ether is preferably 10 to 300 moles, the average number of moles of propylene oxide added is preferably 5 to 70 moles, and the number of carbon atoms in the alkyl group is preferably 10 to 20. The number of carbon atoms in the alkyl group of alkyl glycoside is preferably 8 to 20. The number of carbon atoms in the fatty acid of sucrose fatty acid ester is preferably 8 to 20. The number of carbon atoms in the fatty acid of sorbitan fatty acid ester is preferably 10 to 18. The number of carbon atoms in the fatty acid of polyoxyethylene sorbitan fatty acid ester is preferably 12 to 18, and the average number of moles of ethylene oxide added is preferably 20 to 80 moles. The alkyl chain of the fatty acid alkylolamide preferably has 8 to 20 carbon atoms.

[0030] The nonionic surfactant is preferably polyoxyethylene hydrogenated castor oil, and more preferably polyoxyethylene hydrogenated castor oil having an average number of moles of ethylene oxide added of 5 to 100 moles or 5 to 60 moles. The nonionic surfactant may be used alone or in combination of two or more kinds.

[0031] Examples of amphoteric surfactants include 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, N-lauroyl-N'-carboxymethyl-N'-hydroxyethyl ethylenediamine sodium, alkyl dimethylaminoacetic acid betaine (e.g., lauryl dimethylaminoacetic acid betaine), fatty acid amidopropyl betaine (e.g., coconut oil fatty acid amidopropyl betaine), laurylimidazolinium betaine, alkyl sulfobetaine (e.g., lauramidopropyl hydroxysultaine), and lecithin. Among these, betaine-type amphoteric surfactants are preferred, fatty acid amidopropyl betaine is more preferred, and coconut oil fatty acid amidopropyl betaine is even more preferred. The amphoteric surfactants may be used alone or in combination of two or more.

[0032] Examples of cationic surfactants include quaternary ammonium salt-type cationic surfactants and amino acid-based cationic surfactants. Examples of quaternary ammonium salts include alkylpyridinium salts, benzethonium salts, benzalkonium salts, monoalkyltrimethylammonium salts, and dialkyldimethylammonium salts. Examples of salts include chloride salts and bromide salts. The alkyl and acyl groups that the cationic surfactant may have may have, for example, 8 to 22 or 9 to 21 carbon atoms. Examples of quaternary ammonium salt-type cationic surfactants include cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, behenyltrimethylammonium chloride, distearyldimethylammonium chloride, lauryldimethylbenzylammonium chloride, hexadecyltrimethylammonium bromide, and stearyltrimethylammonium bromide. Examples of amino acid-based cationic surfactants include mono-N-long-chain acyl basic amino acid lower alkyl ester salts. Examples of amino acids that may constitute cationic surfactants include basic amino acids (e.g., natural amino acids such as ornithine, lysine, and arginine, and synthetic amino acids such as α,γ-diaminobutyric acid), and they may be either optically active or racemic. The acyl group that the cationic surfactant may have is preferably a saturated or unsaturated higher fatty acid residue, and examples thereof include single higher fatty acid residues such as lauroyl, myristoyl, palmitoyl, and stearoyl groups; and natural mixed higher fatty acid residues such as coconut oil fatty acid residues and beef tallow fatty acid residues. Examples of lower alkyl esters include alkyl esters having 1 to 8 carbon atoms. Specific examples include methyl ester, ethyl ester, propyl ester, butyl ester, pentyl ester, hexyl ester, heptyl ester, and octyl ester.The lower alkyl ester is preferably in the form of a salt, and specific examples thereof include inorganic salts such as hydrochloride, bromate, sulfate, and phosphate; and organic salts such as glycolate, acetate, lactate, succinate, tartrate, citrate, acidic amino acid salt, higher fatty acid salt, L- or DL-pyrrolidonecarboxylate, pyroglutamate, and p-toluenesulfonate. Examples of amino acid cationic surfactants include N-coconut oil fatty acid acyl-L-arginine ethyl DL-pyrrolidonecarboxylate. The cationic surfactants may be used alone or in combination of two or more.

[0033] The surfactant may be a single type or a combination of two or more types, and preferably includes a nonionic surfactant, an anionic surfactant, or an amphoteric surfactant, more preferably includes a nonionic surfactant and / or an amphoteric surfactant.

[0034] The content of the surfactant is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, and even more preferably 0.1% by mass or more. The upper limit is preferably 10% by mass or less, more preferably 8% by mass or less, and even more preferably 5% by mass or less. Therefore, the content is preferably 0.001 to 10% by mass, more preferably 0.01 to 8% by mass, and even more preferably 0.1 to 5% by mass.

[0035] -Wetting agent- Examples of humectants include sugar alcohols and polyhydric alcohols other than sugar alcohols. Examples of sugar alcohols include sugar alcohols such as sorbitol (sorbitol), erythritol, maltitol, lactitol, xylitol, and reduced starch saccharification products; and polyhydric alcohols such as glycerin, ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol. Examples of polyethylene glycols include polyethylene glycols having an average molecular weight of 150 to 6000, preferably polyethylene glycols having an average molecular weight of 190 to 4000. Specific examples include PEG200, PEG300, PEG400, PEG600, and PEG4000. The average molecular weight is the average molecular weight specified in the Quasi-drug Raw Materials Standards 2021. The humectants described above may be used alone or in combination of two or more.

[0036] The content of the wetting agent is preferably 1 to 70% by mass, more preferably 1 to 65% by mass, even more preferably 1 to 60% by mass, and still more preferably 3 to 60% by mass.

[0037] -Binder- Examples of binders include organic binders and inorganic binders. Examples of organic binders include polysaccharides such as xanthan gum, alginic acid or its salts (e.g., sodium alginate), and carrageenan; cellulose-based binders (e.g., carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationized cellulose, and pharmacologically acceptable salts thereof, such as sodium salts); other polysaccharide thickeners (e.g., guar gum, gellan gum, tragacanth gum, karaya gum, gum arabic, locust bean gum); and synthetic water-soluble polymers (e.g., carboxyvinyl polymer, polyvinylpyrrolidone, sodium polyacrylate, polyvinyl alcohol, propylene glycol alginate). Examples of inorganic binders include thickening silica (silicic anhydride) and aluminum silicate. These binders may be used alone or in combination.

[0038] The binder content, in the case of an organic binder, is preferably 0.001% by mass or more, more preferably 0.01% by mass or more. The upper limit is preferably 10% by mass or less, more preferably 8% by mass or less, and even more preferably 5% by mass or less. Therefore, the binder content is preferably 0.001 to 10% by mass, more preferably 0.001 to 8% by mass, and even more preferably 0.001 to 5% by mass.

[0039] -Fragrance- Examples of fragrances include peppermint oil, spearmint oil, Japanese peppermint oil, anise oil, cassia oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange flower oil), lemongrass oil, jasmine oil, iris oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, laurel oil, chamomile oil, coriander oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, lime oil, mandarin oil, grapefruit oil, yuzu oil, nutmeg oil, lavender oil, paraclese oil, vanilla oil, cinnamon oil, pimento oil, cassia leaf oil, perilla oil, wintergreen oil, and rose oil. Natural essential oils; fragrance components contained in the above natural essential oils, such as carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, limonene, p-methoxycinnamic aldehyde, linalool, linalool oxide, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spilanthol, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, ethyl linalool, methyl jasmonate, vanillin, germacrene, caryophyllene, and viridiflorol;Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, cis-3-hexenol, trans-2-hexenol, hexyl acetate, ethyl 2-methylbutyrate, benzyl alcohol, linalyl acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol, methyl cinnamate, methylheptyne carbonate, ionone, ethyl-β-methylthiopropionate, cis-6-nonenol, methyl anthranilate, ethyl methylphenylglycidate, benzaldehyde, ethyl vanillin, vanillyl butyl ether, furaneol, undecalactone, decalactone, Flavoring ingredients such as ethyl cyclopentenolone, 3-hydroxy-4,5-dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, acetic acid, propionic acid, menthofuran, maltol, ethyl maltol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), 7-methyl-3,5-dihydro-2H-benzodioxepin-3-one, menthyl lactate, ethylene glycol-l-menthyl carbonate, and carrot; plant extracts such as chili pepper extract, ginger extract, pepper extract, Japanese pepper extract, cardamom extract, and vanilla extract;and various blended flavors such as mint, fruit, and herb flavors that are made by combining several fragrance ingredients and natural essential oils. Examples of fragrances that can also function as cooling agents include menthol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), menthyl monosuccinate, menthyl glutarate, isopulegol, menthone glycerol ketal, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, 3-l-menthoxypropane-1,2-diol, 3-((-)-menthoxy)propane-1,2-diol, 5-methyl-2-propan-2-yl-N-(2-pyridin-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3carboxamide) ethyl acetate, 2-isopropyl-N,2,3-trimethylbutyramide, N-[(ethoxycarbonyl)methyl]-p-menthane-3- Carboxamide, Np-benzeneacetatonitrilementhanecarboxamide, N-(2-(pyridin-2-yl)ethyl)-3-p-menthanecarboxamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide, menthyl glyceryl ether, menthyl succinate, N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide, N-ethyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutanamide, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide. Furthermore, as the material for the fragrance (fragrance composition), the fragrance components used in the fragrances used in the Examples described below can also be used. The fragrance may contain a solvent, and examples of the solvent include ethanol, propylene glycol, glycerin fatty acid esters, and triacetin. The fragrance may be used alone or in combination of two or more.

[0040] -solvent- Examples of the solvent include water and lower monohydric alcohols (for example, having 1 to 4 carbon atoms) such as ethyl alcohol.

[0041] -Sweetener- Examples of sweeteners include saccharin, saccharin sodium, stevioside, stevia extract, neohesperidin dihydrochalcone, perillartine, thaumatin, aspartyl phenylalanine methyl ester, acesulfame potassium, maltitol, and mannitol. The sweeteners may be used alone or in combination of two or more.

[0042] -Medicinal ingredients- Examples of medicinal ingredients include fluorine-containing compounds such as metal fluorides (e.g., sodium fluoride, stannous fluoride), monofluorophosphate or salts (e.g., sodium fluorophosphate), etc.; dentin hypersensitivity suppressants such as potassium nitrate, aluminum lactate, strontium chloride, etc.; amino acids such as alanine, pyrrolidonecarboxylic acid or its salts (e.g., sodium salt), glycine, proline, arginine, lysine, glutamine, cysteine, etc.; anti-inflammatory agents such as tranexamic acid, allantoin, allantoin chlorohydroxyaluminum, ε-aminocaproic acid, azulene, sodium azulene sulfonate, glycyrrhetinic acid, glycyrrhizinic acid or salts, Phellodendron bark, and Phellodendron bark extract, etc.; cell activators such as sodium chloride, vitamins, etc.; isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, thymol, lysozyme chloride, chlorhexidine, triclosan, etc. water-soluble copper compounds such as copper chlorophyll and copper gluconate; anti-tartar agents such as zeolite, ethanehydroxydiphosphonate, phytic acid, condensed phosphates such as pyrophosphates (e.g., anhydrous sodium pyrophosphate, tetrapotassium pyrophosphate, disodium dihydrogen pyrophosphate), polyphosphates (e.g., sodium tripolyphosphate, sodium tetrapolyphosphate, potassium tetrapolyphosphate), and metaphosphates (e.g., sodium hexametaphosphate); coating agents such as hydroxyethyl cellulose dimethyl diallyl ammonium chloride; vitamins such as vitamin C (ascorbic acid) and vitamin E (e.g., tocopherol or its derivatives (e.g., tocopherol acetate)), astringents such as sodium chloride, alum, and lysozyme chloride; peptides such as callopeptide; and plant extracts such as thyme, Scutellaria Root, clove, and witch hazel. When the oral composition contains a medicinal ingredient, the content thereof can be set to an effective amount within a pharmacologically acceptable range. The medicinal ingredient may be a single ingredient or a combination of two or more ingredients.

[0043] -Oil-based ingredients- Examples of oily components include hydrocarbons such as squalane, (light) liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols having 8 to 22 carbon atoms such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids having 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid), vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate. The oily components may be used alone or in combination of two or more.

[0044] -Preservatives- Examples of preservatives include methylparaben, parahydroxybenzoic acid esters (e.g., methyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate), sodium benzoate, methyl parahydroxybenzoate, etc. The preservatives may be used alone or in combination of two or more.

[0045] - pH adjuster - Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, tartaric acid, acetic acid, fumaric acid, malic acid, and lactic acid, or their salts (e.g., sodium citrate); inorganic acids such as phosphoric acid (e.g., orthophosphoric acid) and silicic acid, or their salts (e.g., potassium salts, sodium salts, and ammonium salts); and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic acid salts include disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, sodium carbonate, sodium bicarbonate, and sodium silicate. The pH adjusters may be used alone or in combination of two or more.

[0046] -Coloring agent- As the coloring agent, water-soluble dyes are preferred because they are highly safe. Examples include Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105, and Red No. 106.

[0047] Examples of other optional components include inorganic compounds such as zinc oxide, magnesium oxide, and zirconium oxide; natural polymer compounds such as agar, gelatin, starch, and glucomannan; synthetic polymer compounds or copolymers thereof such as polyvinyl acetate, acrylic resin, polyurethane, polyester, polyvinyl chloride, nylon powder, and polyethylene powder; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, and paraffin wax; higher alcohols such as cetanol and stearyl alcohol; polyisobutylene, polybutadiene, urethane, silicone, and natural rubber; DL-alanine; hyaluronic acid or salts (e.g., sodium hyaluronate); and calcium aluminum borosilicate. The content of these other optional components can be appropriately set within a range that does not interfere with the effects of the present invention.

[0048] 2. Dosage forms and uses of oral compositions The oral composition of the present invention is preferably a dentifrice composition. For example, it may be prepared in a liquid form to be used as a liquid dentifrice, or in a paste, gel, or other form to be used as a toothpaste. Of these, toothpaste is preferred.

[0049] The viscosity of the oral composition can be adjusted appropriately depending on the dosage form, etc. For example, the viscosity of a paste or gel oral composition may be 1 to 300 Pa·s, and preferably 30 to 150 Pa·s. In this specification, viscosity refers to the viscosity at 25°C measured using a BH viscometer (B-type viscometer).

[0050] 3. Method for producing oral composition The method for producing the oral composition is not particularly limited, and the oral composition can be produced by any suitable method known in the art depending on the dosage form.

[0051] The shape and material of the container in which the oral composition can be stored are not particularly limited. Any suitable conventional container normally used for oral compositions can be used. Examples of containers that can be used include laminate containers made of layers such as a polyethylene layer, an ethylene methacrylic acid copolymer layer, a polyethylene terephthalate layer, an aluminum layer, a glass vapor deposition layer, a polyvinyl alcohol layer, an ethylene vinyl alcohol copolymer layer, an acrylonitrile copolymer layer, paper, and a recycled plastic layer, as well as polyethylene containers, polyethylene terephthalate containers, polypropylene containers, tubular containers, dispenser containers, and film packaging containers such as pillow packaging. [Example]

[0052] The present invention will be described below with reference to examples, which are not intended to limit the scope of the present invention.

[0053] Examples 1 to 18 The toothpastes of Examples 1 to 18, having the compositions shown in Tables 1 to 3, were prepared by the following method. Purified water was mixed with a water-soluble substance, an inorganic thickener, an organic thickener, and the like, and the mixture was stirred. Then, flavorings, surfactants, and optionally, abrasives and oil-soluble components were added, followed by further stirring under reduced pressure (4 kPa) to obtain the toothpastes. A 5-L kneader (manufactured by Ishiyama Kosakusho Co., Ltd.) was used for production. The toothpastes of Examples 1 to 4, 6, 8, 9, 11 to 13, and 17 can exhibit multiple effects, including at least one of the effects derived from polysaccharidase and protease, and the effects derived from polysaccharidase and lipase. Furthermore, the toothpastes of Examples 5, 7, 10, 14, 15, 16, and 18 can exhibit a high level of the effects derived from polysaccharidase.

[0054] In Tables 1 to 3, the unit of the numerical values ​​shown as the content in each example is "% by mass." Furthermore, "-" in Tables 1 to 3 means "0 (% by mass)."

[0055] Moreover, toothpastes using flavors B to X instead of flavor A used in Examples 1 to 18 can also exhibit the same effects as those of Examples 1 to 18.

[0056] [Table 1]

[0057] [Table 2]

[0058] [Table 3]

[0059] Tables 4 and 5 show the compositions of fragrance A and fragrances B to X used in the examples. Furthermore, Tables 6 to 21 show the compositions of flavors 1 to 9 and solvent 1 shown in Tables 4 and 5. In the table, "cut a% of the front end" means that the first a% is removed when the essential oil is distilled, and "cut b% of the front and back ends" means that the first b% and the last b% are removed when the essential oil is distilled.

[0060] [Table 4]

[0061] [Table 5]

[0062] [Table 6]

[0063] [Table 7]

[0064] [Table 8]

[0065] Table 9

[0066] Table 10

[0067] Table 11

[0068] Table 12

[0069] Table 13

[0070] Table 14

[0071] Table 15

[0072] Table 16

[0073] Table 17

[0074] Table 18

[0075] Table 19

[0076] Table 20

[0077] Table 21

Claims

[Claim 1] (A) Component: An oral composition containing two or more types of enzymes.

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