Enhanced Delivery Epinephrine Compositions

A pharmaceutical composition with a polymer matrix and penetration enhancers like plant extracts and fatty acids addresses the challenge of mucosal barrier absorption, enhancing epinephrine delivery and bioavailability for rapid systemic action.

JP2026035600APending Publication Date: 2026-03-04AQUESTIVE THERAPEUTICS INC
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Filing Date
2025-10-31
Publication Date
2026-03-04

AI Technical Summary

Technical Problem

Existing pharmaceutical compositions face challenges in delivering active ingredients across mucosal barriers efficiently, particularly the oral and sublingual tissues, due to the barriers posed by the oral mucosa, which limits bioavailability and absorption rates.

Method used

The development of a pharmaceutical composition comprising a polymer matrix with epinephrine, adrenoceptor interacting agents, and penetration enhancers such as plant extracts and fatty acids, which enhance the permeability of the mucosal membranes, allowing for increased absorption and bioavailability of the active ingredient.

Benefits of technology

The composition significantly improves the absorption and bioavailability of epinephrine across mucosal surfaces, achieving enhanced delivery and rapid systemic action with increased convenience and patient compliance.

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Abstract

A composition for delivering a drug across the oral mucosa is provided. The present invention provides a pharmaceutical composition comprising: a polymer matrix; a pharmaceutically active ingredient including epinephrine in the polymer matrix; and an adrenoceptor interacting substance.
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