Regimen for repeated topical application of capsaicin patches

Repeating high-concentration capsaicin applications at intervals of 60 to 120 days transforms non-responders into responders, effectively addressing neuropathic pain in patients who initially do not respond to conventional treatments.

JP2026035695APending Publication Date: 2026-03-04GRUNENTHAL GMBH
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Filing Date
2025-11-26
Publication Date
2026-03-04

AI Technical Summary

Technical Problem

A significant number of patients do not respond adequately to conventional high-concentration capsaicin patches for neuropathic pain, and existing data lack insight into responder rates beyond the first application.

Method used

A regimen involving repeated applications of high-concentration capsaicin or capsaicinoid topical dosage units, with application periods ranging from 60 to 120 days between each application, to convert initial non-responders into responders.

Benefits of technology

Repeated topical administration of capsaicin converts over one-third of initial non-responders into responders, significantly increasing the responder rate and providing sustained pain relief.

✦ Generated by Eureka AI based on patent content.

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Abstract

To provide a means for making topical treatment of peripheral neuropathic pain with capsaicin available to patients who do not initially respond to high concentration topical capsaicin dosage units such as high concentration topical patches or creams.SOLUTION: A regimen for the repeated treatment of a neuropathic condition, preferably a peripheral neuropathic pain, comprising one or more high-concentration capsaicin and / or capsaicinoid topical dose units, preferably a first application of a high-concentration capsaicin and / or capsaicinoid patch, followed by one or more subsequent high-concentration capsaicin and / or capsaicinoid topical dose units, preferably a second application of a high-concentration capsaicin and / or capsaicin patch, wherein the time period between the first application and the second application is preferably shortened in order to increase the responder rate.SELECTED DRAWING: None
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