Compositions, hair care products, and hair shampoos capable of bidirectionally adjusting the scalp microbiome.

Abstract

The objective is to provide a composition that can bidirectionally adjust the scalp microbiome by increasing the growth of beneficial bacteria such as Staphylococcus epidermidis on the scalp, while simultaneously suppressing the growth of harmful bacteria such as Staphylococcus aureus and Malassezia on the scalp. [Solution] The problem can be solved by a composition containing zinc L-pyrrolidone carboxylate, maltooligosaccharides, hinokitiol, and ion-exchanged water, which can bidirectionally adjust the scalp microbiome.

Description

Technical Field

[0001] The disclosure in the present application relates to a composition, a hair care product, and a hair shampoo that can bidirectionally regulate the scalp microbiome.

Background Art

[0002] On the surface of healthy skin, there exists a microbial community named the microbiome, similar to the intestinal tract system. The scalp is a part of the skin and is covered with hair. Therefore, secreted sebum, sweat, etc. are easily utilized by the microbial flora, providing a comfortable breeding environment. Staphylococcus epidermidis, a bacterium of the scalp resident microbiota, decomposes the triglyceride component of sebum into fatty acids and glycerol. Fatty acids keep the skin weakly acidic and play a role in preventing the growth of the alkaline-preferring pathogenic bacterium Staphylococcus aureus. Glycerol has a moisturizing effect on the scalp and can maintain the scalp barrier function. Therefore, Staphylococcus epidermidis is recognized as a good bacterium for the scalp. On the other hand, when the skin is damaged or becomes alkaline, Staphylococcus aureus multiplies in large numbers, the pH environment of the skin is destroyed, Staphylococcus epidermidis decreases rapidly, causing inflammation, abscesses, etc. Malassezia (M. furfur), a fungus of the scalp resident microbiota, decomposes the triglyceride component of sebum into saturated fatty acids and unsaturated fatty acids. Unsaturated fatty acids irritate the scalp, causing scalp inflammation, dandruff, itching, etc. In addition, the sebaceous glands of the scalp are most densely distributed throughout the body, and the distribution of sweat glands is the second most after the hands and feet. Therefore, compared with other parts of the skin, the scalp secretes more sebum and sweat, and the balance of the microbial flora is more likely to be disrupted. Even minor changes occurring in the body, such as exercise, ultraviolet rays, emotions, and stress, may disrupt the balance of the microbial flora.

Summary of the Invention

Problems to be Solved by the Invention

[0003] To maintain the balance of the scalp microbiome, simply controlling beneficial bacteria upward or harmful bacteria downward is not effective. For example, when controlling beneficial bacteria upward, harmful bacteria may also be nourished and proliferate. Furthermore, since harmful bacteria are divided into the bacterium Staphylococcus aureus and the fungus Malassezia, it is difficult to control both simultaneously with a single component. Using fungicides and antifungal agents simultaneously may also inhibit the growth of beneficial bacteria such as Staphylococcus epidermidis. Therefore, to maintain the balance of the scalp microbiome and prevent scalp inflammation, there is a need for a technology that can increase the growth of beneficial bacteria while simultaneously suppressing the growth of harmful bacteria.

[0004] Furthermore, even if there is a composition that can maintain the balance of the scalp microbiome, it may be difficult to use it directly on the scalp.

[0005] The disclosures in this application have been made in view of the above-mentioned problems, and their purpose is to provide a composition that can bidirectionally adjust the scalp microbiome, increasing the growth of beneficial bacteria such as Staphylococcus epidermidis on the scalp while simultaneously suppressing the growth of harmful bacteria such as Staphylococcus aureus and Malassezia on the scalp. Furthermore, the purpose of the disclosures in this application is to provide a hair care product and a hair shampoo to which the above technology is applied, and the provided hair shampoo has good basic performance in terms of cleansing power and combability. [Means for solving the problem]

[0006] The problem described in this application can be solved by a composition comprising zinc L-pyrrolidone carboxylate, maltooligosaccharides, hinokitiol, and ion-exchanged water that can bidirectionally adjust the scalp microbiome, as well as by a hair care product and hair shampoo containing the composition. [Modes for carrying out the invention]

[0007] <Embodiment of a composition capable of bidirectionally adjusting the scalp microbiome> The composition (hereinafter sometimes simply referred to as "the composition") that can adjust the scalp microbiome bidirectionally according to the embodiment comprises zinc L-pyrrolidone carboxylate, maltooligosaccharides, hinokitiol, and ion-exchanged water. There are no particular restrictions on components other than zinc L-pyrrolidone carboxylate, maltooligosaccharides, hinokitiol, and ion-exchanged water that may be included in the composition (hereinafter sometimes referred to as "optional additional components"), as long as they do not impair the effects of the present invention. Although not limited, the following components can be cited as optional additional components: (1) Oily raw materials. For example, hydrocarbon oils, esters, natural oils and synthetic oils, higher alcohol oils, fatty acid oils, waxy oils, silicone oils or their derivatives, phytosterol derivatives, protein derivatives, lanolin, lanolin derivatives, lecithin and other oily bases, essential oils, fragrances or cooling agents, UV absorbers, etc. (2) Water-soluble raw materials. For example, polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, and polyethylene glycol; lower alcohols such as ethanol; pH adjusters and buffers such as citric acid, sodium citrate, lactic acid, and sodium hydroxide; sugars such as sucrose, trehalose, xylitol, and oligosaccharides; inorganic salts such as sodium chloride, potassium chloride, calcium chloride, sodium bicarbonate, sodium carbonate, anhydrous sodium carbonate, and magnesium sulfate; stabilizers such as sodium metaphosphate, ethylenediaminetetraacetic acid, and disodium ethylenediaminetetraacetic acid (sodium edetate); and antioxidants such as dibutylhydroxytoluene (BHT) and ascorbic acid. (3) Others. Preservatives, pigments, powders, blood circulation promoters, natural extracts derived from plants and animals, flavonoids such as anthocyanins and their derivatives, vitamins and their derivatives, amino acids, photosensitizers, preservatives, cooling agents or aromatics such as menthol, peppermint water, rose water, water-swellable clay minerals, various powders, ultraviolet scattering agents, pigments, etc. When adding any of the above optional additional components, one type may be selected at will, or two or more types may be added in combination.

[0008] As an example of a composition according to the embodiment, the composition may consist only of zinc L-pyrrolidone carboxylate, maltooligosaccharides, hinokitiol, and deionized water. In this case, the content of zinc L-pyrrolidone carboxylate is preferably 0.1-10% by mass, the content of maltooligosaccharides is preferably 5-20% by mass, and the content of hinokitiol is preferably 0.01-1% by mass, with the remainder being adjusted with deionized water.

[0009] Furthermore, if the composition contains optional additives other than zinc L-pyrrolidone carboxylate, maltooligosaccharides, hinokitiol, and ion-exchanged water, as described above, the content of zinc L-pyrrolidone carboxylate, maltooligosaccharides, and hinokitiol should be within the above range, and the remaining amount after adding the optional additives should be adjusted with ion-exchanged water.

[0010] While not limited to specific types, maltooligosaccharides such as maltotriose, maltotetraose, and maltopentaose are preferred examples, with maltotetraose being more preferred.

[0011] <Embodiment of a hair care product> Next, a hair care product according to the embodiment will be described. The hair care product includes any of the compositions according to the embodiment. The hair care product is not particularly limited as long as it includes the compositions according to the embodiment, but examples include hair shampoo, hair conditioner, hair treatment, hair mask, scalp cleanser, scalp essence, etc.

[0012] <Embodiment of hair shampoo> Next, an embodiment of a hair shampoo will be described as an example of a hair care product. The hair shampoo according to this embodiment contains a surfactant, a cationic polymer, any composition according to the embodiment, a chelating agent, a preservative, a fragrance, a pH adjuster, and ion-exchanged water.

[0013] In addition to the surfactant, cationic polymer, any composition according to the embodiment, chelating agent, preservative, fragrance, pH adjuster, and ion-exchanged water mentioned above, other components that may be included in the hair shampoo include the components obtained by excluding the surfactant, cationic polymer, chelating agent, preservative, fragrance, and pH adjuster from the optional additional components of the composition according to the embodiment described above.

[0014] Furthermore, if the composition according to the embodiment contains any of the following: a chelating agent, a preservative, a fragrance, or a pH adjuster, when manufacturing the hair shampoo according to the embodiment, the components already added to the composition according to the embodiment do not need to be added, or the same or different types of components may be added. In other words, if the hair shampoo according to the embodiment contains a surfactant, a cationic polymer, a chelating agent, a preservative, a fragrance, a pH adjuster, and ion-exchanged water, then these components may be components included in the composition according to the embodiment.

[0015] As an example of a hair shampoo according to the embodiment, the hair shampoo may consist only of a surfactant, a cationic polymer, any composition according to the embodiment, a chelating agent, a preservative, a fragrance, a pH adjuster, and deionized water. In that case, the surfactant content is preferably 10-24% by mass, the cationic polymer content is preferably 0.1-1.0% by mass, the composition according to the embodiment is preferably 0.05-5.0% by mass, the chelating agent content is preferably 0.05-0.15% by mass, the preservative content is preferably 0.5-1.0% by mass, the fragrance content is preferably 0-1.5% by mass, and the pH adjuster content is preferably 0.01-1.0% by mass, with the remainder being adjusted with deionized water.

[0016] Furthermore, if the hair shampoo optionally contains ingredients other than surfactants, cationic polymers, any of the compositions according to the embodiment, chelating agents, preservatives, fragrances, pH adjusters, and ion-exchanged water, as described above, the content of surfactants, cationic polymers, any of the compositions according to the embodiment, chelating agents, preservatives, fragrances, and pH adjusters should be within the above range, and the remaining amount after adding the optional additional ingredients should be adjusted with ion-exchanged water.

[0017] Examples of surfactants, though not limited to them, include coconut fatty acid alanine salt, alkyl sulfonate, coconut fatty acid taurine salt, coconut fatty acid taurine taurine salt, alkylamide betaine type amphoteric surfactants, and amide sulfobetaine type amphoteric surfactants. The surfactant may be one type or may contain two or more types.

[0018] As an example of the embodiments of the surfactant described above, an example is one in which coconut fatty acid alanine salt is present in an amount of 0.5 to 7% by mass, alkyl sulfonate in an amount of 2 to 10% by mass, and one or more selected from the group consisting of coconut fatty acid taurine salt, coconut fatty acid taurine taurine salt, alkylamide betaine type amphoteric surfactant, and amide sulfobetaine type amphoteric surfactant in an amount of 2 to 7% by mass.

[0019] Examples of coconut fatty acid alanine salts, though not limited to them, include sodium cocoyl alanine, sodium lauroyl alanine, and sodium lauroyl methyl alanine. Examples of alkyl sulfonates, though not limited to them, include sodium olefin (C14-16) sulfonate.

[0020] Examples of the coconut fatty acid taurine salt include, but are not limited to, sodium cocoamido methyl taurine, sodium cocoamido methyl taurine taurine, etc. Examples of the coconut oil fatty acid taurine taurine salt include, but are not limited to, sodium cocoamido methyl taurine taurine, etc. Examples of the alkyl amide betaine type amphoteric surfactant include, but are not limited to, cocoamidopropyl betaine, etc. Examples of the amide sulfobetaine type amphoteric surfactant include, but are not limited to, cocoamidopropyl hydroxysultaine, lauryl hydroxysultaine, etc.

[0021] Examples of the cationic polymer include, but are not limited to, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-67, guar hydroxypropyltrimonium chloride, hydroxypropyltrimonium chloride starch, etc. One or more cationic polymers may be included.

[0022] Examples of the chelating agent include, but are not limited to, disodium EDTA, etc. Examples of the preservative include, but are not limited to, sodium benzoate, phenoxyethanol, etc. Examples of the pH adjuster include, but are not limited to, citric acid, etc.

[0023] The hair shampoo of the embodiment can be produced, for example, by the procedure described below. Add the cationic polymer to ion-exchanged water at room temperature and heat to 80°C while stirring. Mix the surfactant, chelating agent, and pH adjuster (citric acid) at 80°C while stirring. Mix the composition according to the embodiment, preservative, and fragrance at 50°C or lower while stirring.

Examples

[0024] Hereinafter, examples of the present invention will be described. Note that the present invention is not limited to the scope of the examples.

[0025] <Examples 1 to 5 and Comparative Examples 1 to 5: Composition> The composition was prepared by mixing all the components shown in Tables 1 and 2 at room temperature. The blending amounts of each component described in Tables 1 and 2 are the blending amounts relative to the total mass of the composition (unit: mass%). Zinc L-pyrrolidone carboxylate was AJIDEW ZN-100 manufactured by Ajinomoto Health Supply Co., Ltd., maltotetraose was Leogard MT manufactured by Lion Specialty Chemicals Co., Ltd., and hinokitiol was hinokitiol manufactured by Takasago Perfumery Co., Ltd.

[0026] Table 3 shows the results of the bacterial growth tests of the compositions prepared in Examples 1 to 5 and Comparative Examples 1 to 5. The bacterial growth test method and evaluation criteria are as follows. At 37°C, Staphylococcus epidermidis and Staphylococcus aureus were cultured in NBRC802 medium, and Malassezia was cultured in YM medium. Using MiniPhoto 518R, the bacterial solution was diluted so that the OD600 absorbance was 0.08 - 0.13, and the further 100-fold diluted solution was used as the test bacterial solution for evaluation. 180 μl of the test bacterial solution was mixed with 20 μl of the compositions of Examples 1 to 5 and Comparative Examples 1 to 5, or sterilized water, cultured at 37°C for 24 hours, and the OD600 was measured using Infinite 200Pro MPlex. Using the OD600 of the bacterial solution containing sterilized water as a control, if the value was higher, it was judged as growth, if the value was lower, it was judged as inhibition, and if there was no significant difference, it was judged as no effect.

[0027]

Table 1

[0028]

Table 2

[0029]

Table 3

[0030] <Examples 6 - 10 and Comparative Examples 6 - 10: Hair Shampoo> Shear shampoos were prepared using the ingredients shown in Tables 4 and 5. The method for manufacturing the hair shampoos was as follows: Cationic polymers were dispersed in deionized water at room temperature and heated to 80°C. Surfactants, pH adjusters, and chelating agents were added at 70-80°C, stirred and dissolved, and then cooled. After cooling to below 50°C, the compositions of Examples 1-5 and Comparative Examples 1-5, preservatives, and fragrances were added and stirred and dissolved.

[0031] Sodium cocoyl alanine is Eversoft ACS manufactured by Sino Lion (USA) Ltd., sodium olefin (C14-16) sulfonate is Liporan LJ-441 manufactured by Lion Specialty Chemicals Co., Ltd., sodium cocoyl methyl taurate is Diapon K-SF manufactured by NOF Corporation, cocamidopropyl betaine is Anhitol 55AB manufactured by Kao Corporation, and polyquaternium-10 is Poise C-150L manufactured by Kao Corporation. Other ingredients are general-purpose products.

[0032] Table 6 shows the performance evaluation results of the hair shampoos prepared in Examples 6-10 and Comparative Examples 6-10. In Table 6, the evaluation method and evaluation criteria for the cleansing effect of the shampoo composition are as follows: Selected subjects washed their hair with the shampoo used for evaluation, and the condition of the scalp and hair before and after washing was observed using a scalp condition measuring device. "Good" means that no sebum or dirt remains on the scalp and hair after washing. "Too high" means that no sebum or dirt remains on the scalp and hair after washing, but the stratum corneum is peeled off due to excessive washing. "Too low" means that sebum or dirt remains on the scalp and hair after washing.

[0033] Table 6 shows the evaluation method and criteria for the combability of shampoo compositions as follows: Selected subjects wash their hair with the shampoo used for evaluation, and the combability of the hair is evaluated. Good means that the hair is smooth to the touch during rinsing and after drying. Poor means that the hair feels very stiff during rinsing and tangled after drying.

[0034] Table 6 shows the evaluation method and criteria for the scalp inflammation prevention effect of the shampoo composition. Selected subjects washed their hair with the shampoo used for evaluation for 30 consecutive days, and the scalp inflammation prevention effect was evaluated after the period of use. "Effective" indicates that scalp inflammation such as itching, redness, and dandruff has improved. "Ineffective" indicates that scalp inflammation such as itching, redness, and dandruff has not improved.

[0035] [Table 4]

[0036] [Table 5]

[0037] [Table 6]

Claims

1. Contains L-pyrrolidone carboxylate zinc, maltooligosaccharides, hinokitiol, and ion-exchanged water. A composition that can bidirectionally regulate the scalp microbiome.

2. The composition capable of bidirectionally adjusting the scalp microbiome comprises zinc L-pyrrolidone carboxylate, maltooligosaccharides, hinokitiol, and ion-exchanged water. The content of zinc L-pyrrolidonecarboxylate is 0.1-10% by mass. The maltooligosaccharide content is 5-20% by mass, The hinokitiol content is 0.01-1% by mass, The remaining amount is the aforementioned ion-exchanged water. A composition that can bidirectionally adjust the scalp microbiome as described in claim 1.

3. The maltooligosaccharides are at least one selected from the group consisting of maltotriose, maltotetraose, and maltopentaose. A composition that can bidirectionally adjust the scalp microbiome as described in claim 1.

4. The aforementioned maltooligosaccharide is maltotetraose. A composition capable of bidirectionally adjusting the scalp microbiome as described in claim 3.

5. A hair care product comprising a composition that can bidirectionally adjust the scalp microbiome according to any one of claims 1 to 4, The hair care product is selected from the group consisting of hair shampoo, hair conditioner, hair treatment, hair mask, scalp cleanser, and scalp essence. Hair care products.

6. The hair care product described in claim 5 is a hair shampoo, and the hair shampoo is The composition includes a surfactant, a cationic polymer, a composition capable of bidirectionally adjusting the scalp microbiome, a chelating agent, a preservative, a fragrance, a pH adjuster, and deionized water. Hair shampoo.

7. The hair shampoo comprises the surfactant, the cationic polymer, the composition capable of bidirectionally adjusting the scalp microbiome, the chelating agent, the preservative, the fragrance, the pH adjuster, and the ion-exchanged water. The surfactant content is 10-24% by mass. The content of the cationic polymer is 0.1-1.0% by mass. The composition that can bidirectionally adjust the scalp microbiome contains 0.05-5.0% by mass. The content of the chelating agent is 0.05-0.15% by mass. The content of the aforementioned preservative is 0.5-1.0% by mass. The fragrance content is 0-1.5% by mass. The pH adjusting agent is citric acid, and the content of the citric acid is 0.01-1.0% by mass. The remaining amount is the aforementioned ion-exchanged water. The hair shampoo according to claim 6.

8. The surfactant includes one or more selected from the group consisting of coconut fatty acid alanine salt, alkyl sulfonate, coconut fatty acid taurine salt, coconut fatty acid taurine taurine salt, alkylamide betaine type amphoteric surfactant, and amide sulfobetaine type amphoteric surfactant. The shampoo according to claim 6.

9. The aforementioned coconut fatty acid alanine salt is contained in an amount of 0.5 to 7% by mass. The alkyl sulfonate is contained in an amount of 2 to 10% by mass. The following is included in 2 to 7% by mass of one or more selected from the group consisting of coconut fatty acid taurine salt, coconut fatty acid taurine taurine salt, alkylamidobetaine type amphoteric surfactant, and amidesulfobetaine type amphoteric surfactant. The shampoo according to claim 8.

10. The cationic polymer includes one or more selected from the group consisting of polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-67, guar hydroxypropyltrimonium chloride, and hydroxypropyltrimonium chloride starch. The shampoo according to claim 6.

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