Concentrated hot spring water

Abstract

This product provides concentrated hot spring water that has the effect of suppressing itching of the skin in humans and animals. [Solution] The concentrated hot spring water is produced by concentrating hot spring water, wherein the source temperature of the hot spring water is 30°C or lower, and the components contained in 1 kg are fluoride ions of 2.0 mg or more, carbonate ions of 10.0 mg or more, calcium ions of 15.0 mg or less, and potassium ions of 5.0 mg or less, and in the concentration process, the volume is concentrated to 1 / 2 to 1 / 10 while maintaining the temperature of the hot spring water at 60°C or lower, and the pH value after concentration is 8.0 or higher.

Description

Technical Field

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[0001] The present invention relates to concentrated hot spring water produced by concentrating hot spring water.

Background Art

[0002] Conventionally, it is known that taking a bath in hot spring water or drinking hot spring water (drinking spring water) has various effects. Among hot springs, hot springs known as beauty hot springs are said to be effective for rough skin and atopic dermatitis, and many people troubled by rough skin and the like visit beauty hot spring resorts. Also, there is a legend that animals without medicine have entered hot springs and healed their wounds since ancient times.

[0003] On the other hand, chemical solutions using the effects of hot spring water have also been developed (for example, see Patent Document 1). The chemical solution of Patent Document 1 concentrates the volume of hot spring water to 1 / 2 to 1 / 150 and contains tree extracts such as bamboo and Japanese cypress. According to the chemical solution of Patent Document 1, it is said to be effective not only for specific diseases such as atopic dermatitis but also for a wide range of diseases.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] By the way, the inventor of the present application conducted research on the causes of rough skin and obtained the knowledge that mainly the skin becomes inflamed and itchy, and further inflammation becomes severe by scratching the itch, leading to rough skin and atopic dermatitis. And the knowledge that hot spring water has the function of suppressing this itch was also obtained, and research was conducted to further enhance its effect.

[0006] The present invention was made to solve the above problems and aims to provide concentrated hot spring water that has the effect of suppressing itching of the skin of humans and animals. [Means for solving the problem]

[0007] The concentrated hot spring water of the present invention is Concentrated hot spring water is produced by concentrating hot spring water. The aforementioned hot spring water The spring water temperature is below 30℃. The components contained in 1 kg are: fluoride ions 2.0 mg or more, carbonate ions 10.0 mg or more, calcium ions 15.0 mg or less, and potassium ions 5.0 mg or less. In the concentration process, While maintaining the temperature of the hot spring water below 60 degrees Celsius, the volume is concentrated to 1 / 2 to 1 / 10 of its original volume. The pH value after concentration was set to 8.0 or higher. It is concentrated hot spring water.

[0008] Tables 1 and 2 show hot spring sources throughout Japan and the components of their hot spring water. As shown in Tables 1 and 2, when hot spring water from all over Japan (pH 6.3-9.95, spring temperature 14.7-100°C) was collected and its effects were examined, it was found that alkaline water (pH of the source water is 8.0 or higher, or pH of the concentrated water is 8.0 or higher), and water with high levels of fluoride ions and carbonate ions tended to suppress itching.

[0009] Therefore, it is preferable that the components contained in 1 kg of hot spring water be 2.0 mg or more of fluoride ions and 10.0 mg or more of carbonate ions. On the other hand, it is preferable that the calcium ions be 15.0 mg or less and the potassium ions be 5.0 mg or less.

[0010] If hot spring water exceeding these concentrations is used, a large amount of crystalline material will be generated during the concentration and filtration process, making the filtration process difficult and potentially damaging the concentration equipment. Furthermore, skin dryness will worsen. Therefore, the above-mentioned range for the concentration of these components is preferable.

[0011] Therefore, it is preferable that the components contained in 1 kg of hot spring water be 2.0 mg or more of fluoride ions and 10.0 mg or more of carbonate ions. On the other hand, it is preferable that the calcium ions be 15.0 mg or less and the potassium ions be 5.0 mg or less.

[0012] It is preferable to use alkaline hot spring water as the source of the solution, and for the pH value after concentration to be 8.0 or higher.

[0013] Hot spring water with a temperature of 30°C or lower was found to be more effective in suppressing itching, while hot spring water with a temperature of 60°C or higher tended to be less effective in suppressing itching. Therefore, it is preferable to use hot spring water with a source temperature of 30°C or lower.

[0014] Even if the source water temperature is 30°C or lower, if the water temperature rises during concentration, it may affect the active ingredients and reduce the efficacy. For this reason, it is preferable to maintain the temperature of the hot spring water at 60°C or lower during the concentration process to suppress the reduction in efficacy.

[0015] The hot spring water used in concentrated hot spring water may be from multiple sources. These multiple sources may be mixed before, during, or after concentration.

[0016] The concentrated hot spring water may be mixed with a humectant having hydrophilic and water-retaining properties, and / or a gelling agent. As a humectant having hydrophilic and water-retaining properties, for example, a known heparin-like substance can be used. As a gelling agent, a known aqueous gel or oily gel can be used.

[0017] By mixing concentrated hot spring water with a humectant and / or gelling agent, high moisturizing power can be obtained. In addition, the active ingredients in the hot spring water can remain on the skin for a longer period, thus prolonging the effects of the concentrated hot spring water. [Effects of the Invention]

[0018] Concentrated hot spring water with a volume concentrated to 1 / 2, 1 / 3, 1 / 5, 1 / 7, 1 / 10 (also referred to as 2-fold, 3-fold, 5-fold, 7-fold, 10-fold concentration respectively) was generated. When applied to itching and rough skin, the higher the concentration, the faster the itching and inflammation subsided. When applied to mosquito bites etc., the swelling subsided and the itching stopped.

[0019] The concentrated hot spring water exhibited an effect of suppressing itching against all of histamine H1, IgE, IgG, and IL-31, which are the causes of itching.

[0020] Animal experiments were conducted on the possibility of controlling atopic dermatitis with the concentrated hot spring water. Normally, in response to external invaders by the immune system, substances such as cytokines IL31, IL-1β, TNF-α are released from T cells to suppress the invading substances and try to normalize the skin environment. However, skin diseases such as atopic dermatitis are caused when the cytokine group is abnormally released or when they are not recovered in the body. The concentrated hot spring water of the present invention suppressed those cytokine groups, and there was a possibility of improving atopic dermatitis.

[0021] The efficacy of suppressing itching is effective uniformly not only in humans but also in animals with hair, and the effect was obtained faster in animals.

[0022] Higher effects were obtained with concentrated hot spring water obtained by mixing a plurality of hot spring waters from different sources. For example, the volume of each of the hot spring waters from source A (Mie Prefecture), source D (Mie Prefecture), and source J (Fukushima Prefecture) was concentrated to 1 / 5 (5-fold concentration), and these were mixed at a volume ratio of 1:1:1 and made viscous for use in a plurality of pets. As a result, higher effects were obtained than when each hot spring water was individually concentrated and made viscous. As in this example, it was found in tests on numerous pets that mixing a plurality of hot spring waters from different sources is more effective against any symptoms.

[0023] Based on the above, the concentrated hot spring water according to the present invention has the effect of suppressing itching of the skin in humans and animals. [Brief explanation of the drawing]

[0024] [Figure 1] Figure 1 is a table showing hot spring sources throughout Japan and the components of their hot spring water. [Figure 2] Figure 2 is a table showing hot spring sources throughout Japan and the components of their hot spring water. [Figure 3] Figure 3 is a photograph showing the condition before use in Example 3. [Figure 4] Figure 4 is a photograph showing the condition before use in Example 3. [Figure 5] Figure 5 is a photograph showing the condition after use in Example 3. [Figure 6] Figure 6 is a photograph showing the condition before use in Example 4. [Figure 7] Figure 7 is a photograph showing the condition after use in Example 4. [Figure 8] Figure 8 is a photograph showing the condition before use in Example 5. [Figure 9] Figure 9 is a photograph showing the condition after use (30 days later) in Example 5. [Figure 10] Figure 10 is a photograph showing the condition after use (60 days later) in Example 5. [Figure 11] Figure 11 is a photograph showing the condition before use in Example 6. [Figure 12] Figure 12 is a photograph showing the condition after use in Example 6. [Figure 13] Figure 13 is a photograph showing the condition before use in Example 7. [Figure 14] Figure 14 is a photograph showing the condition after use in Example 7. [Figure 15] Figure 15 is a photograph showing the condition before use in Example 8. [Figure 16] Figure 16 is a photograph showing the condition after use in Example 8. [Figure 17]Figure 17 is a photograph showing the condition before use in Example 9. [Figure 18] Figure 18 is a photograph showing the condition after use in Example 9. [Figure 19] Figure 19 is a photograph showing the condition before use in Example 10. [Figure 20] Figure 20 is a photograph showing the condition after use in Example 10. [Figure 21] Figure 21 is a photograph showing the condition before use in Example 11. [Figure 22] Figure 22 is a photograph showing the condition after use in Example 11. [Modes for carrying out the invention]

[0025] (Example 1) There are many types of skin problems in pets, including atopic dermatitis, contact allergies, food allergies, hormonal skin diseases, pyoderma, hot spots, demodectic mange, and fungal dermatitis. Statistics show that approximately 40% of pets visiting veterinary hospitals are being treated for skin problems. Examples of pet skin problems • It often licks its front paws. • Always scratches with its hind legs • Hair started falling out Scratch, scratch... looks like it's itchy. • Looks like it's scratching its ears. I scratched it so much it's all wet and oozing... • Her stomach is red.

[0026] The effectiveness of concentrated hot spring water (5x concentrated) according to the present invention in improving dermatitis and pressure ulcers was investigated. As a result, 1) In samples cultured after diluting the bacterial suspension and allowing it to stand for 24 hours, the concentration treatment resulted in significantly fewer colonies compared to distilled water. 2) The group treated with the concentrated solution showed significantly higher gene expression of the inflammatory cytokines IL-1β and TNFα compared to the group treated with distilled water. Furthermore, pathological analysis revealed a reduction in epidermal thickening. 3) A 15-year-old neutered male Toy Poodle, suffering from renal failure and difficulty walking, developed a pressure ulcer on its hindquarters. After applying a concentrated solution for 5 months, the ulcer completely healed. No antibiotics or other medications were administered. 4) A male cat (age unknown) had a large defect in the skin on the left side of its neck, but it improved after 2 months with application of concentrated solution and administration of antibiotics (subcutaneous injection).

[0027] (Example 2) How to use concentrated hot spring water Initially, use a fairly generous amount to moisturize the affected area and suppress bacteria. The guideline is 4-5 sprays per application (if using a spray). Use it about 7 times a day, every 2 hours. Once the condition improves, take it about three times a day.

[0028] (Example 3) Target: Cattle Symptoms: dermatitis Provided by: Ranch owner Location: Okayama Prefecture Duration of use: 2 months (applied twice) Figures 3 and 4 are photographs showing the condition before use in Example 3. Figure 5 is a photograph showing the condition after use in Example 3. We were consulted about a lack of effective medication for cow dermatitis, so we conducted a test. The medication was applied once a month, and the hair grew back completely in 50 days. The individual identification number on the ear allowed us to confirm it was the same animal.

[0029] (Example 4) Target: Dogs (Poodles) Symptoms: dermatitis Provided by: Groomer Location: Aichi Prefecture Usage period: 2 months Figure 6 is a photograph showing the condition before use in Example 4. Figure 7 is a photograph showing the condition after use in Example 4.

[0030] (Example 5) Target: Dogs (Shiba Inu) Symptoms: Pregnancy melanosis Provided by: Volunteer group Location: Aichi Prefecture Usage period: 30 days, 60 days Figure 8 is a photograph showing the condition before use in Example 5. Figure 9 is a photograph showing the condition after use (30 days later) in Example 5. Figure 10 is a photograph showing the condition after use (60 days later) in Example 5. Hormonal changes during pregnancy and breastfeeding can cause darkening of the skin's pigmentation. Continued use will restore a healthy skin tone.

[0031] (Example 6) Target: Dogs (Golden Retrievers) Symptom: Inflammation Provided by: Volunteer group Location: Aichi Prefecture Usage period: 3 hours Figure 11 is a photograph showing the condition before use in Example 6. Figure 12 is a photograph showing the condition after use in Example 6.

[0032] (Example 7) Target: Dogs (Dachshunds) Symptom: Inflammation Provided by: Volunteer group Location: Aichi Prefecture Usage period: 20 days Figure 13 is a photograph showing the condition before use in Example 7. Figure 14 is a photograph showing the condition after use in Example 7. The "before" photo shows the cat as it was when it was rescued. Its claws had grown quite long. After the treatment, its fur had grown back, and its claws had been trimmed, making it look completely different.

[0033] (Example 8) Target: Humans Symptoms: Atopic dermatitis Provider: General public Usage period: 30 days Figure 15 is a photograph showing the condition before use in Example 8. Figure 16 is a photograph showing the condition after use in Example 8. This is a case study of a high school boy who had suffered from atopic dermatitis since elementary school.

[0034] (Example 9) Target: Humans Symptoms: Allergy Provider: General public (male in his 50s) Location: Osaka Usage period: 2 days Figure 17 is a photograph showing the condition before use in Example 9. Figure 18 is a photograph showing the condition after use in Example 9. My arm was itchy and I scratched it, but it calmed down after two days of use.

[0035] (Example 10) Target: Humans Symptoms: Skin irritation after shaving Provided by: University student (20s) Location: Kyoto Usage period: 2 weeks Figure 19 is a photograph showing the condition before use in Example 10. Figure 20 is a photograph showing the condition after use in Example 10. I went to a dermatologist for three years but saw no improvement. After applying concentrated water, the bleeding improved significantly in two weeks.

[0036] (Example 11) Target: Humans Symptoms: Atopic dermatitis Provider: General public (female in her 30s) Location: Osaka Usage period: 60 days Figure 21 is a photograph showing the condition before use in Example 11. Figure 22 is a photograph showing the condition after use in Example 11. The itching was severe, but the symptoms have improved.

[0037] Although embodiments of the present invention have been described above, the embodiments described above are merely illustrative examples for carrying out the present invention. Therefore, the present invention is not limited to the embodiments described above, and it is possible to carry out the present invention by appropriately modifying the embodiments described above without departing from the spirit of the invention.

Claims

1. Concentrated hot spring water is produced by concentrating hot spring water. The aforementioned hot spring water The temperature of the hot spring source is below 30°C. The components contained in 1 kg are: fluoride ions 2.0 mg or more, carbonate ions 10.0 mg or more, calcium ions 15.0 mg or less, and potassium ions 5.0 mg or less. In the concentration process, While maintaining the temperature of the hot spring water below 60 degrees Celsius, the volume is concentrated to 1 / 2 to 1 / 10 of its original volume. The pH value after concentration is 8.0 or higher. Concentrated hot spring water.

2. Obtained by using multiple hot spring waters from different sources, The concentrated hot spring water according to claim 1.

3. A mixture of a hydrophilic and water-retentive humectant and / or a gelling agent, Concentrated hot spring water according to claim 1 or claim 2.

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