Liquid oral components

Abstract

The present invention aims to provide an oral composition, particularly a liquid oral composition, that achieves both flavor development and suppression of oral irritation. [Solution] A liquid oral composition comprising: (A) component: at least one selected from the group consisting of glycyrrhizic acid and its salts; (B) component: at least one selected from the group consisting of condensed phosphoric acid, phytic acid and their salts; and (C) component: a fragrance, wherein the content of component (A) is 0.015% by mass or more and less than 0.2% by mass, the content of component (B) is 0.07 to 1.5% by mass, and preferably the ratio of the content of component (A) to the content of component (B) is 0.03 to 1.5.

Description

Technical Field

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[0001] The present invention relates to a liquid oral composition.

Background Art

[0002] Glycyrrhizinate such as dipotassium glycyrrhizinate (GK2) has an anti-inflammatory effect, and when formulated in an oral composition, it can enhance the effect of preventing periodontal disease while giving a sweet feeling of use.

[0003] Patent Document 1 describes a cleaning method of using a liquid oral composition containing glycyrrhizinate after removing food residues from teeth.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, when glycyrrhizic acid or its salt is formulated in an oral composition containing a fragrance, there is a problem that the expression of the fragrance (aroma) caused by the fragrance may be reduced.

[0006] An object of the present invention is to provide an oral composition, particularly a liquid oral composition, in which both fragrance expression and suppression of oral irritation are achieved.

Means for Solving the Problems

[0007] As a result of various investigations into means of solving this problem, we found that by incorporating condensed phosphoric acid, phytic acid, or salts thereof in a specific ratio, the reduction in flavor expression caused by glycyrrhizic acid or its salts can be suppressed, and by incorporating glycyrrhizic acid or its salts in a specific ratio, oral irritation caused by condensed phosphoric acid, phytic acid, or their salts can also be suppressed.

[0008] The present invention provides the following [1] to [9]. [1] A liquid oral composition comprising (A) component: at least one selected from the group consisting of glycyrrhizic acid and its salts, (B) component: at least one selected from the group consisting of condensed phosphoric acid, phytic acid and their salts, and (C) component: a fragrance, wherein the content of component (A) is 0.015% by mass or more and less than 0.2% by mass, and the content of component (B) is 0.07 to 1.5% by mass. [2] The liquid oral composition according to [1], wherein the ratio of the content of component (A) to the content of component (B) is 0.03 to 1.5. [3] The liquid oral composition according to [1] or [2], wherein the content of component (C) is 0.000001 to 2% by mass. [4] A liquid oral composition according to any one of [1] to [3], wherein component (A) is at least one of dipotassium glycyrrhizinate and monoammonium glycyrrhizinate. [5] The liquid oral composition according to any one of the items [1] to [4], wherein component (B) is at least one selected from the group consisting of sodium pyrophosphate, potassium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, and phytic acid. [6] A liquid oral composition according to any one of [1] to [5], wherein component (C) is at least one selected from the group consisting of menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene. [7] An oral composition comprising (A) component: at least one selected from the group consisting of glycyrrhizic acid and its salts, (B) component: at least one selected from the group consisting of condensed phosphoric acid, phytic acid and their salts, and (C) component: a fragrance, wherein the content of component (A) is 0.11 to 0.25% by mass, and the content of component (B) is 0.15 to 0.95% by mass. [8] The oral composition according to [7], wherein the ratio of the content of component (A) to the content of component (B) is 0.15 or more. [9] The oral composition according to [7] or [8], wherein the ratio of the content of component (A) to the content of component (B) is 0.2 or more. [Effects of the Invention]

[0009] According to the present invention, it is possible to provide an oral composition, particularly a liquid oral composition, that achieves both flavor development and suppression of oral irritation. [Modes for carrying out the invention]

[0010] [1. Oral composition] The oral composition or liquid oral composition of the present invention contains component (A), component (B), and component (C).

[0011] [(A) component] Component (A) is at least one selected from the group consisting of glycyrrhizic acid and its salts. Examples of glycyrrhizinate salts include alkali metals such as sodium salts and potassium salts, and ammonium salts, with potassium salts and ammonium salts being preferred, and potassium salts being more preferred. More specifically, examples include dipotassium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, and monoammonium glycyrrhizinate. Of these, dipotassium glycyrrhizinate and monoammonium glycyrrhizinate are preferred, and dipotassium glycyrrhizinate is more preferred. By containing component (A), oral irritation can be suppressed.

[0012] Glycyrrhizic acid and its salts may be derived from natural raw materials such as plants, or they may be manufactured industrially. Component (A) may be a single type selected from glycyrrhizic acid and its salts of different types, raw materials, and manufacturing methods, or a combination of two or more types.

[0013] -(A) Content of component- The content of component (A) is preferably 0.015% by mass or more, 0.03% by mass or more, or 0.07% by mass or more, more preferably 0.11% by mass or more, even more preferably 0.15% by mass or more, and even more preferably 0.17% by mass or more, relative to the total amount of the composition of the present invention. This suppresses oral irritation. The upper limit is preferably 0.25% by mass or less, more preferably 0.23% by mass or less, and even more preferably 0.22% by mass or less. This suppresses sweetness, resulting in a good user experience, allows the aroma derived from the fragrance to be felt, and improves flavor expression. Therefore, the content of component (A) is preferably 0.015 to 0.25% by mass, 0.03 to 0.25% by mass or 0.07 to 0.25% by mass, more preferably 0.11 to 0.25% by mass, even more preferably 0.15 to 0.23% by mass, and even more preferably 0.17 to 0.22% by mass, relative to the total amount of the composition of the present invention.

[0014] Furthermore, when the composition of the present invention is a liquid oral composition, the content of component (A) is preferably 0.015% by mass or more, more preferably 0.017% by mass or more, even more preferably 0.018% by mass or more, and even more preferably 0.03% by mass or more, based on the total amount of the composition of the present invention. This suppresses oral irritation. The upper limit is preferably less than 0.2% by mass, even more preferably 0.18% by mass or less, and even more preferably 0.17% by mass or less. This suppresses sweetness, resulting in a good user experience, allows the user to perceive the fragrance derived from the fragrance, and improves flavor expression. Therefore, the content of component (A) is preferably 0.015% by mass or more and less than 0.2% by mass, or 0.017% by mass or more and less than 0.2% by mass, even more preferably 0.018 to 0.18% by mass, and even more preferably 0.03 to 0.17% by mass, based on the total amount of the composition of the present invention.

[0015] [(B) Component] (B) Component is at least one selected from the group consisting of condensed phosphoric acid, phytic acid, and salts thereof. Examples of condensed phosphoric acids include linear polyphosphates (e.g., pyrophosphate, tripolyphosphate, high-polymerization polyphosphates) and cyclic metaphosphates (e.g., trimetaphosphate, tetrametaphosphate, hexametaphosphate). The condensed phosphoric acids and their salts may also be anhydrous. Component (B) is preferably pyrophosphate, tripolyphosphate, hexametaphosphate, phytic acid, or phytic acid, with pyrophosphate and tripolyphosphate being more preferred. Examples of salts include inorganic base salts such as alkali metal salts (e.g., sodium salt, potassium salt), alkaline earth metal salts (e.g., calcium salt, magnesium salt), copper salt, zinc salt, aluminum salt, and ammonium salt; and organic base salts such as triethylammonium salt, triethanolammonium salt, pyridinium salt, and diisopropylammonium salt, with alkali metal salts being preferred, and sodium salt and potassium salt being more preferred. Of these, sodium pyrophosphate, potassium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, and phytic acid are preferred, and sodium pyrophosphate and sodium tripolyphosphate are more preferred. Component (B) may be one of these alone or a combination of two or more.

[0016] -(B) Content of component - The content of component (B) is preferably 0.07% by mass or more, or 0.1% by mass or more, more preferably 0.15% by mass or more, and even more preferably 0.3% by mass or more, or 0.4% by mass or more, relative to the total amount of the composition of the present invention. This allows the aroma derived from the fragrance to be perceived and results in good flavor expression. The upper limit is preferably 1.5% by mass or less, or 1% by mass or less, more preferably 0.95% by mass or less, and even more preferably 0.7% by mass or less, or 0.6% by mass or less. This prevents excessive oral irritation. Therefore, the content of component (B) is preferably 0.07 to 1.5% by mass or 0.1 to 1% by mass, more preferably 0.15 to 0.95% by mass, and even more preferably 0.3 to 0.7% by mass or 0.4 to 0.6% by mass, relative to the total amount of the composition of the present invention.

[0017] -(A) / (B)- In the composition of the present invention, the ratio (A) / (B) of the content of component (A) to the content of component (B) is preferably 0.03 or more, or 0.05 or more, more preferably 0.08 or more, or 0.15 or more, and even more preferably 0.2 or more, or 0.21 or more. Thereby, oral irritation can be further suppressed. The upper limit is preferably 1.5 or less, or 1 or less, more preferably 0.8 or less, or 0.75 or less, and even more preferably 0.5 or less. Thereby, the sweetness is suppressed and the usability is better, the aroma derived from the fragrance can be felt more, and the flavor expressiveness is better. Therefore, the ratio (A) / (B) is preferably 0.03 or more, 0.05 or more, 0.08 or more, or 0.15 or more, more preferably 0.2 or more, and even more preferably 0.2 to 1.5, or 0.2 to 1, and even more preferably 0.2 to 0.8, 0.2 to 0.75, 0.2 to 0.5, or 0.21 to 0.5.

[0018] When the composition of the present invention is a liquid oral composition, the ratio (A) / (B) is preferably 0.03 or more, 0.05 or more, or 0.08 or more, more preferably 0.1 or more, more preferably 0.12 or more, and even more preferably 0.14 or more, or 0.2 or more. The upper limit is preferably 1.5 or less, more preferably 1 or less, more preferably 0.8 or less, or 0.75 or less, and even more preferably 0.5 or less. Therefore, the ratio (A) / (B) is preferably 0.03 to 1.5, 0.05 to 1.5, or 0.08 to 1.5, more preferably 0.1 to 1.5, or 0.1 to 1, more preferably 0.12 to 0.8, or 0.12 to 0.75, and even more preferably 0.14 to 0.5, or 0.2 to 0.5.

[0019] [Component (C)] (C) component is a fragrance. By including (C) component, the composition of the present invention can express its flavor well. Examples of fragrances include peppermint oil, spearmint oil, Japanese mint oil, anise oil, cassia oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange blossom oil), lemongrass oil, jasmine oil, vanilla oil, iris oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, laurel oil, chamomile oil, coriander oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, lime oil, mandarin oil, grapefruit oil, yuzu oil, nutmeg oil, lavender oil, paracles oil, vanilla oil, cinnamon oil, pimento oil, and cinnamon oil. Natural essential oils such as leaf oil, perilla oil, wintergreen oil; fragrance components contained in the above natural essential oils, such as carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, limonene, p-methoxycinnamic aldehyde, linalool, linalool oxide, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spiranthol, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, ethyl linalool, methyl jasmonate, vanillin, etc.Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, cis-3-hexenol, trans-2-hexenol, hexyl acetate, ethyl-2-methyl butyrate, benzyl alcohol, linalyl acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol, methyl cinnamate, methylheptin carbonate, ionone, ethyl-β-methylthiopropionate, cis-6-nonenol, methyl anthranilate, ethyl methylphenyl glycidate, benzaldehyde, ethyl vanillin, vanillyl butyl ether, furaneol, undecalactone Fragrance components such as decalactone, ethylcyclopentenolone, 3-hydroxy-4,5-dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, acetate acid, propionic acid, menthofran, maltol, ethylmaltol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), 7-methyl-3,5-dihydro-2H-benzodioxepin-3-one, menthyl lactate, ethylene glycol-l-menthyl carbonate, caron, etc.; plant extracts such as chili pepper extract, ginger extract, pepper extract, and Japanese pepper extract;Examples include various blended flavors such as mint, fruit, and herb, which are combined with several fragrance components and natural essential oils. In addition, fragrances that can also function as cooling agents include, for example, menthol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), menthyl lactate, menthyl monosuccinate, isopulegol, menthone glycerol ketal, N-(4-cyanomethylphenyl)-p-menthane carboxamide, 3-l-menthoxypropane-1,2-diol, 5-methyl-2-propan-2-yl-N-(2-pyridin-2-ylethyl)cyclohexane-1-carboxamide, ethyl 3-(p-menthane-3-carboxamide)acetate, 2-isopropyl-N,2,3-trimethylbutylamide, N-[(ethoxycarbonyl)methyl]-p-menthane-3-carboxamide, N-p-benzenediazonitrile menthane carboxamide, N-(2-(pyridin-2-yl)ethyl)-3-p-menthane carboxamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide, menthyl glyceryl ether, and menthyl succinate.;

[0020] Among these, menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene are preferred, menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, and methyl salicylate are more preferred, and menthol is even more preferred. By containing these fragrances as component (C), the aroma derived from the fragrance can be felt more, and the flavor expressiveness is good, so it is more preferred.

[0021] (C) Component may be one of the above components alone, or a combination of two or more components of different types, raw materials, or manufacturing methods, but it is more preferable to include a combination of two or more, three or more, or four or more components selected from the group consisting of menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene. Preferred such combinations include menthol and carvone, menthol and cineole, menthol and anethole, menthol and cinnamic aldehyde, menthol and eugenol, menthol and methyl salicylate, menthol and thymol, and menthol and limonene, and combinations of menthol, 1,8-cineole and anethole, menthol, anethole and cinnamic aldehyde, and menthol, carvone and cinnamic aldehyde. More preferably, a combination of menthol, carvone, and methyl salicylate, and a combination of menthol, cinnamic aldehyde, and methyl salicylate are preferred, and a combination of menthol, carvone, cinnamic aldehyde, and methyl salicylate is even more preferred, and a combination of menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, and methyl salicylate is even more preferred, and a combination of menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene is even more preferred. By including the above fragrance combinations in component (C), the reduction in flavor expression caused by component (A) is suppressed by component (B), thereby allowing the flavor to be more fully expressed and the remarkable effects of the present invention to be more favorably exhibited.

[0022] The content of component (C) is preferably 0.000001% by mass or more, more preferably 0.01% by mass or more, or 0.1% by mass or more, relative to the total amount of the composition of the present invention. The upper limit is preferably 2% by mass or less, more preferably 1% by mass or less, or 0.5% by mass or less. Therefore, the content of component (C) is preferably 0.000001 to 2% by mass, more preferably 0.01 to 1% by mass, or 0.1 to 0.5% by mass, relative to the total amount of the composition of the present invention.

[0023] The total amount of at least one fragrance selected from the group consisting of menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene is preferably 5% by mass or more, more preferably 7% by mass or more, and even more preferably 10% by mass or more, relative to the total amount of component (C). The upper limit is preferably 100% by mass or less, more preferably 95% by mass or less, and even more preferably 90% by mass or less. Therefore, the total amount of at least one fragrance selected from the group consisting of menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene is preferably 5 to 100% by mass, more preferably 7 to 95% by mass, and even more preferably 10 to 90% by mass, relative to the total amount of component (C).

[0024] If component (C) contains menthol, the menthol content is preferably 0.1 to 70% by mass, or 1 to 70% by mass, more preferably 3 to 60% by mass, relative to the total amount of component (C). If component (C) contains carvone, the carvone content is preferably 0.1 to 30% by mass, and more preferably 0.5 to 25% by mass, relative to the total amount of component (C). When component (C) contains 1,8-cineole, the carvone content is preferably 0.1 to 30% by mass, and more preferably 0.5 to 25% by mass, relative to the total amount of component (C). If component (C) contains anethole, the anethole content is preferably 0.1 to 30% by mass, and more preferably 0.5 to 25% by mass, relative to the total amount of component (C). If component (C) contains cinnamic aldehyde, the cinnamic aldehyde content is preferably 0.1 to 30% by mass, and more preferably 0.5 to 25% by mass, relative to the total amount of component (C). If component (C) contains eugenol, the eugenol content is preferably 0.1 to 20% by mass, and more preferably 0.5 to 15% by mass, relative to the total amount of component (C). If component (C) contains methyl salicylate, the methyl salicylate content is preferably 0.1 to 40% by mass, and more preferably 0.5 to 35% by mass, relative to the total amount of component (C).

[0025] Furthermore, solvents may be used when compounding these fragrances. Examples of solvents include ethanol, propylene glycol, glycerin fatty acid esters, and triacetin.

[0026] [Optional ingredients] Oral compositions may contain other optional components besides the above components (A) to (C), as appropriate, depending on the application and dosage form, as long as they do not interfere with the effects of the present invention. Specifically, surfactants, abrasives, binders, wetting agents, and optionally pH adjusters, sweeteners, preservatives, colorants, various medicinal ingredients, and oily components may be added. Furthermore, if the composition of the present invention is a liquid oral composition, other optional components other than the above components (A) to (C) include, for example, surfactants, binders, preservatives, wetting agents, pH adjusters, sweeteners, colorants, various medicinal ingredients, and solvents.

[0027] - Surfactants - As the surfactant, at least one selected from nonionic surfactants, anionic surfactants, and amphoteric surfactants can be used.

[0028] (Nonionic surfactant) Various conventionally known nonionic surfactants can be used. Examples include polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid esters, sugar alcohol fatty acid esters such as sucrose fatty acid esters, maltose fatty acid esters, maltitol fatty acid esters, and lactol fatty acid esters, alkylolamides, alkyl glucosides, polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene glycol fatty acid esters, polyethylene glycol fatty acid esters, polyoxyethylene polyoxypropylene glycol, fatty acid diethanolamides such as lauric acid mono or diethanolamide, polyoxyethylene alkyl ethers, and polyoxyethylene alkylphenyl ethers. The alkyl and acyl groups may be linear or branched, saturated or unsaturated, and the number of carbon atoms is usually 10 to 25. Of these, polyoxyethylene hydrogenated castor oil is preferred.

[0029] The average number of moles of ethylene oxide added to polyoxyethylene hydrogenated castor oil is typically 2 to 100 moles, preferably 5 to 100 moles, and more preferably 10 to 100 moles.

[0030] (Anionic surfactant) Examples of anionic surfactants include alkyl sulfates, α-olefin sulfonates, N-acyl sulfonates, sulfates of glycerin fatty acid esters, acyl amino acids, and acyl taurines. The alkyl and acyl groups may be linear or branched, saturated or unsaturated, and typically have 10 to 20 carbon atoms, preferably 12 to 18, and more preferably 12 to 14. The salt can be selected from pharmacologically acceptable salts. Examples of pharmacologically acceptable salts include base addition salts and amino acid salts. Specific examples include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts.

[0031] Examples of alkyl sulfates include lauryl sulfate and myristoyl sulfate. Examples of α-olefin sulfonates include tetradecene sulfonates and other α-olefin sulfonates with 12 to 18 carbon atoms.

[0032] Examples of acyl amino acids include lauroyl sarcosine salt and lauroyl glutamate. Examples of acyl taurines include lauroyl methyl taurine salt.

[0033] Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride sodium monosulfate and sodium lauryl sulfoacetate.

[0034] (amphoteric surfactant) Examples of amphoteric surfactants include N-alkyldiaminoethylglycines such as N-lauryldiaminoethylglycine and N-myristyldiaminoethylglycine; betaine-type amphoteric surfactants such as N-alkylN-carboxymethylammonium betaine, 2-alkyl-1-hydroxyethylimidazoline betaine sodium, alkyldimethylaminoacetic acid betaine (e.g., lauryldimethylaminoacetic acid betaine), and fatty acid amidopropyldimethylaminoacetic acid betaine (e.g., cocamidopropyl betaine); imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salts (e.g., N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine), coconut oil fatty acid imidazolinium betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine; and alkylbetaines such as lauryldimethylaminoacetic acid betaine.

[0035] The content of these surfactants is typically 0.001 to 10% by mass, preferably 0.1 to 5% by mass, and more preferably 0.5 to 3% by mass, based on the total amount of the composition of the present invention.

[0036] -Abrasive- Either inorganic or organic abrasives may be used as the abrasive. Examples of inorganic abrasives include silica-based abrasives (abrasive silica) such as precipitated silica, crystalline silica, amorphous silica, silica gel, aluminosilicate, zirconosilicate, and titanium-bonded silica; zeolites; calcium phosphate compounds such as anhydrous calcium hydrogen phosphate, calcium hydrogen phosphate dihydrate, dicalcium phosphate dihydrate or anhydrous, monocalcium phosphate, tricalcium phosphate, and tetracalcium phosphate; calcium carbonate-based abrasives such as calcium carbonate; aluminum hydroxide, alumina, magnesium carbonate, trimagnesium phosphate, calcium sulfate, bentonite, zirconium silicate, and hydroxyapatite. Examples of organic abrasives include synthetic resin-based abrasives. The abrasive content is preferably 7 to 50% by mass, and more preferably 10 to 30% by mass, based on the total amount of the composition of the present invention.

[0037] - Binding agent - Examples of binders include polysaccharide thickeners (e.g., xanthan gum, guar gum, gellan gum, tragacanth gum, karaya gum, arabic gum, locust bean gum, carrageenan, sodium alginate), cellulosic binders (e.g., carboxymethylcellulose (CMC), hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationized cellulose, etc., and pharmaceutically acceptable salts thereof such as their sodium salts), and synthetic water-soluble polymers (e.g., sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol, propylene glycol alginate). Furthermore, inorganic binders such as thickening silica and aluminum silicate can also be incorporated.

[0038] -Wetting agent- As a wetting agent, sugar alcohols and polyhydric alcohols other than sugar alcohols are preferred. Examples of sugar alcohols include sorbitol, xylitol, erythritol, maltitol, lactitol, and reduced starch saccharides; and polyhydric alcohols include glycerin, ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol. Examples of polyethylene glycols include polyethylene glycol with an average molecular weight of 150 to 6000, preferably polyethylene glycol with an average molecular weight of 190 to 630. Specifically, examples include PEG200, PEG300, PEG400, and PEG600. The content of the wetting agent is typically 1 to 70% by mass, preferably 1 to 65% by mass, more preferably 1 to 60% by mass, even more preferably 3 to 60% by mass, and even more preferably 3 to 30% by mass, based on the total amount of the composition of the present invention.

[0039] - pH adjuster - Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, and lactic acid, or inorganic acids such as their salts (e.g., sodium citrate), or their salts (e.g., potassium salts, sodium salts, and ammonium salts), and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic salts include disodium hydrogen phosphate and sodium dihydrogen phosphate. The amount of pH adjuster can usually be such that the pH of the oral composition after addition is 5.0 to 9.0, preferably 6.0 to 8.5.

[0040] In this specification, the pH value usually refers to the value obtained 3 minutes after the start of measurement at 25°C. The pH value can be measured using, for example, a pH meter (model number HM-42X) manufactured by Toa DKK Co., Ltd.

[0041] -Sweetener- Examples of sweeteners include saccharin, sodium saccharin, aspartame, stevioside, stevia extract, neohesperidin dihydrochalcone, perillartin, thaumatin, and aspartylphenylalanine methyl ester.

[0042] - Preservatives - Examples of preservatives include benzoates such as sodium benzoate, and parahydroxybenzoic acid esters such as methyl parahydroxybenzoate, ethyl parahydroxybenzoate, and butyl parahydroxybenzoate. Preservatives may be used individually or in combination of two or more.

[0043] -Coloring agent- Examples of coloring agents include natural pigments such as safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, red yeast rice pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cocoa pigment, spirulina blue pigment, and tamarind pigment, as well as legally approved pigments such as Red No. 2, Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 227, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1, and riboflavin, copper chlorophyll sodium, and titanium dioxide. When the oral composition contains a coloring agent, its content is preferably 0.00001 to 3% by mass of the total amount of the composition of the present invention.

[0044] -Medicinal ingredients- Other medicinal ingredients besides those listed above (A) and (B) may be used, for example: bactericidal or antibacterial agents such as lysozyme chloride, triclosan, isopropylmethylphenol, zinc gluconate, zinc citrate, chlorhexidine hydrochloride, cetylpyridinium chloride, benzalkonium chloride, and benzethonium chloride; tartar preventative agents such as zeolite and ethane hydroxydiphosphonate; anti-inflammatory agents such as tranexamic acid, glycyrrhetinic acid or its salts (e.g., stearyl glycyrrhetinate), allantoin, allantoin chlorohydroxyaluminum, ε-aminocaproic acid, and azulene; and dextranase, amylase, and protease. Examples include enzymes such as mutanase; fluorides such as sodium fluoride, sodium monofluorophosphate, and stannous fluoride; vitamins such as vitamin C (e.g., ascorbic acid), vitamin E (e.g., tocopherol acetate, tocopherol nicotinate, tocopherol), pyridoxine; blood circulation promoters such as vitamin E; astringents such as sodium chloride, alum, and lysozyme chloride; hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; cell activators such as sodium chloride and vitamins; water-soluble copper compounds such as copper chlorophyll and copper gluconate; amino acids such as alanine, glycine, and proline; and peptides such as caropeptides. When an oral composition contains medicinal ingredients, the amount can be used within a range that does not hinder the effects of the present invention (a range that is pharmaceutically acceptable).

[0045] -Oily components- Examples of oily components include hydrocarbons such as squalane, (light) liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols with 8 to 22 carbon atoms such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids with 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid); vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate.

[0046] -Other optional components- The oral composition of this embodiment may contain other optional components in an optionally suitable amount.

[0047] In this embodiment, examples of other optional components that the oral composition may contain include inorganic compounds such as titanium mica, titanium dioxide, zinc oxide, magnesium oxide, and zirconium oxide; natural polymer compounds such as agar, gelatin, starch, and glucomannan; synthetic polymer compounds or copolymers thereof such as polyvinyl acetate, acrylic resin, polyurethane, polyester, polyvinyl chloride, nylon powder, and polyethylene powder; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, and paraffin wax; higher alcohols such as cetanol and stearyl alcohol; and polyisobutylene, polybutadiene, urethane, silicone, and natural rubber. The content of these other optional components can be appropriately set within a range that does not hinder the effects of the present invention.

[0048] [2. Dosage Form and Use] The dosage form of the oral composition can be appropriately selected depending on the intended use and is not particularly limited. Examples include liquids (solutions, emulsions, suspensions, syrups, etc.), semi-solids (gels, creams, pastes, etc.), and solids (tablets, particulates, capsules, films, kneaded products, molten solids, waxy solids, elastic solids, soft capsules, etc.).

[0049] The oral composition of the present invention can be used in solid dosage forms such as lozenges, gummies, gums, and toothpastes. It can also be used in semi-solid dosage forms such as toothpastes and gel toothpastes. Liquid oral compositions can be used in concentrated or undiluted forms such as mouthwashes, liquid toothpastes, and oral fresheners (sprays, etc.). Of these, mouthwashes are preferred. [Examples]

[0050] The present invention will be described below with reference to examples. The following examples are not intended to limit the present invention.

[0051] Mouthwash compositions with the compositions shown in Tables 1, 2, and 4, and toothpaste compositions with the composition shown in Table 3 were prepared by conventional methods and evaluated using the following methods. The results are shown in Tables 1 to 4.

[0052] [Raw materials used] Details of the raw materials used are as follows.

[0053] -(A) component- Dipotassium glycyrrhizinate: Manufactured by Maruzen Pharmaceutical Co., Ltd. Monoammonium glycyrrhizinate: Manufactured by Maruzen Pharmaceutical Co., Ltd.

[0054] -(B) Component- Sodium polyphosphate (including sodium tripolyphosphate and sodium pyrophosphate): Manufactured by Taihei Chemical Industry Co., Ltd. Anhydrous sodium pyrophosphate: Manufactured by Taihei Chemical Industry Co., Ltd. Phytic acid: 50% by mass aqueous solution manufactured by Fuso Chemical Industries Co., Ltd. Sodium hexametaphosphate: Manufactured by Taihei Chemical Industry Co., Ltd. Potassium pyrophosphate: Manufactured by Taihei Chemical Industry Co., Ltd.

[0055] -(C) Component- Fragrance components A-P: (The composition of each fragrance is shown in Table 5.)

[0056] -Other ingredients- Sorbitol (70%): Manufactured by Mitsubishi Corporation Life Sciences Co., Ltd. Propylene glycol: Manufactured by ADEKA Corporation POE Hydrogenated Castor Oil (100): Manufactured by Japan Surfactant Industry Co., Ltd., HCO-100 Xanthan gum: Manufactured by DSP Gokyo Food & Chemical Co., Ltd. Anhydrous silicic acid (abrasive silica): Zeodent 115, manufactured by Evonik. Citric acid: Manufactured by Komatsuya Co., Ltd. Sodium citrate: Manufactured by Komatsuya Co., Ltd. purified water

[0057] [Method for evaluating flavor expression] (1) Evaluation method for mouthwash (liquid oral composition) The samples were evaluated in a sensory test conducted by 10 expert panelists. Each participant took 10 mL of the sample (liquid oral composition) into their mouth, rinsed for 30 seconds, and evaluated whether the fragrance-derived aroma was immediately detected in the nose according to the scoring criteria below. The average of the 10 participants' scores was calculated, and the flavor expression was evaluated according to the evaluation criteria below.

[0058] (2) Method for evaluating toothpaste composition (toothpaste) The toothpaste was evaluated in a sensory test conducted by 10 expert panelists. Each participant squeezed 1g of the toothpaste composition from the tube onto a toothbrush, brushed for 3 minutes, and evaluated whether a fragrance-derived aroma was immediately noticeable in the nose upon putting the toothpaste in the mouth, according to the scoring criteria below. The average of the 10 participants' scores was calculated, and the flavor expression was evaluated using the following criteria.

[0059] -Scoring Criteria- 4 points: I strongly noticed the fragrance derived from the perfume. 3 points: I could slightly detect the fragrance derived from the perfume. 2 points: I didn't really notice the fragrance derived from the perfume. 1 point: I didn't detect any fragrance from the perfume.

[0060] -Evaluation Criteria for Flavor Expression- ◎: Average score of 3.5 points or more. ○: Average score of 3.0 or higher but less than 3.5. △: Average score between 2.0 and 3.0. ×: Average score below 2.0 points.

[0061] [Methods for evaluating oral stimulation] (1) Evaluation method for mouthwash (liquid oral composition) The product was evaluated through a sensory test conducted by 10 expert panelists. Each participant held 10 mL of the sample (liquid oral composition) in their mouth, rinsed for 30 seconds, and evaluated whether they felt any irritation on their tongue and gums according to the scoring criteria below. The average of the 10 participants' scores was calculated, and the flavor expression was evaluated according to the evaluation criteria below.

[0062] (2) Method for evaluating toothpaste composition (toothpaste) The toothpaste was evaluated in a sensory test conducted by 10 expert panelists. Each participant squeezed 1g of the toothpaste composition from the tube, placed it on a toothbrush, and brushed for 3 minutes. They then evaluated whether they felt any irritation on their tongue and gums according to the scoring criteria below. The average of the 10 participants' scores was calculated, and the flavor expression was evaluated according to the evaluation criteria below.

[0063] -Scoring Criteria- 4 points: No oral irritation was felt. 3 points: I didn't feel much irritation in my mouth. 2 points: I felt some irritation in my mouth. 1 point: I felt a lot of irritation in my mouth.

[0064] -Evaluation Criteria for Oral Stimulation- ◎: Average score of 3.5 points or more. ○: Average score of 3.0 or higher but less than 3.5. △: Average score between 2.0 and 3.0. ×: Average score below 2.0 points.

[0065] [Table 1]

[0066] [Table 2]

[0067] [Table 3]

[0068] [Table 4]

[0069] [Table 5]

[0070] [Table 6]

[0071] [Table 7]

[0072] [Table 8]

[0073] While the comparative mouthwash compositions received low ratings for either flavor expression or oral irritation, the mouthwash compositions and toothpaste compositions of Examples 1 to 22, which contained components (A) to (C) and whose content of components (A) and (B) met the predetermined numerical range, received high ratings for both flavor expression and oral irritation, demonstrating a desirable balance between flavor expression and suppression of oral irritation. Furthermore, when samples prepared in the same manner as in Examples 1-22 and Comparative Examples 1-6, except that fragrance components B-P were used instead of fragrance component A, were evaluated for flavor expression and oral irritation as shown above, the same results as those shown in Tables 1-4 were obtained. The oral compositions of the present invention can exhibit good flavor expression and suppression of oral irritation regardless of which fragrance is used. Moreover, it is presumed that using fragrances containing at least one of the following, such as fragrances A-P, including menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene, will result in more favorable flavor expression, even when glycyrrhizic acid or a salt thereof is used in combination.

[0074] The following are representative formulations of the present invention.

[0075] [Table 9]

Claims

1. (A) Components: At least one selected from the group consisting of glycyrrhizic acid and its salts, (B) Component: At least one selected from the group consisting of condensed phosphoric acid, phytic acid, and salts thereof, (C) Ingredient: Fragrance It contains, (A) The content of component is 0.015% by mass or more and less than 0.2% by mass, (B) The content of component is 0.07 to 1.5% by mass. Liquid oral composition.

2. The liquid oral composition according to claim 1, wherein the ratio of the content of component (A) to the content of component (B) is 0.03 to 1.

5.

3. The liquid oral composition according to claim 1 or 2, wherein the content of component (C) is 0.000001 to 2% by mass.

4. (A) The liquid oral composition according to claim 1 or 2, wherein component (A) is at least one of dipotassium glycyrrhizinate and monoammonium glycyrrhizinate.

5. The liquid oral composition according to claim 1 or 2, wherein component (B) is at least one selected from the group consisting of sodium pyrophosphate, potassium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, and phytic acid.

6. The liquid oral composition according to claim 1 or 2, wherein component (C) is at least one selected from the group consisting of menthol, carvone, 1,8-cineole, anethole, cinnamic aldehyde, eugenol, methyl salicylate, thymol, and limonene.

7. (A) Components: At least one selected from the group consisting of glycyrrhizic acid and its salts, (B) Component: At least one selected from the group consisting of condensed phosphoric acid, phytic acid, and salts thereof, (C) Ingredient: Fragrance It contains, (A) The content of component is 0.11 to 0.25% by mass, (B) The content of component is 0.15 to 0.95% by mass. Oral composition.

8. The oral composition according to claim 7, wherein the ratio of the content of component (A) to the content of component (B) is 0.15 or more.

9. The oral composition according to claim 7 or 8, wherein the ratio of the content of component (A) to the content of component (B) is 0.2 or more.

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