Topical pharmaceutical composition containing loxoprofen

A topical pharmaceutical composition with loxoprofen and specific ratios of NSAIDs reduces skin irritation, addressing the issue of application site discomfort caused by indomethacin, diclofenac sodium, felbinac, and salicylic acids.

JP2026085899APending Publication Date: 2026-05-25DAIICHI SANKYO HEALTHCARE
View PDF 3 Cites 0 Cited by

Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
DAIICHI SANKYO HEALTHCARE
Filing Date
2025-11-12
Publication Date
2026-05-25

AI Technical Summary

Technical Problem

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin, diclofenac sodium, felbinac, salicylic acids, and heparinoids cause skin irritation at the application site, posing a challenge for topical pharmaceutical compositions.

Method used

A topical pharmaceutical composition containing loxoprofen or its salts and hydrates, blended with ingredients like indomethacin, diclofenac sodium, felbinac, or salicylic acids, reduces skin irritation by maintaining specific content ratios and using ethanol, pH adjusters, and water in the formulation process.

Benefits of technology

The composition effectively alleviates skin irritation at the application site, providing a more comfortable and effective treatment option for NSAIDs.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure 2026085899000007
    Figure 2026085899000007
  • Figure 2026085899000001
    Figure 2026085899000001
  • Figure 2026085899000002
    Figure 2026085899000002
Patent Text Reader

Abstract

To provide a topical pharmaceutical composition containing indomethacin, diclofenac sodium, felbinac, salicylic acids, or heparins, wherein irritation to the application site is reduced. [Solution] A topical pharmaceutical composition that contains component (A) and component (B) below, wherein component (A) is one or more selected from the group consisting of components (A-1) to (A-5) below, and which reduces irritation to the application site. Ingredient (A-1): Indomethacin Ingredient (A-2): Diclofenac sodium Ingredient (A-3): Felbinac Ingredients (A-4): Salicylic acids Ingredient (A-5): Heparinoid Ingredient (B): One or more selected from the group consisting of loxoprofen, its salts, and their hydrates.
Need to check novelty before this filing date? Find Prior Art