Liquid oral components

Abstract

The present invention aims to provide a liquid oral composition that has an astringent sensation, effectively suppresses discoloration over time, and improves the sour taste during use. [Solution] The present invention relates to a liquid oral composition comprising (A) component: pyridoxine or a salt thereof, (B) component: glycerin, and (C) component: at least one selected from the group consisting of sorbitol, propylene glycol, and polyethylene glycol, wherein the ratio of the content (mass%) of component (B) to the content (mass%) of component (C) is less than 1, more preferably (D) component: a predetermined sweetener, and even more preferably (E) component: at least one selected from the group consisting of tocopherol acetate and tocopherol nicotinate.

Description

Technical Field

[0001] The present invention relates to a liquid oral composition.

Background Art

[0002] Conventionally, from the viewpoint of imparting a periodontal disease preventive effect, more specifically, a short-chain fatty acid reducing effect, a glycation reaction inhibitory effect, a metabolism promoting effect, and an anti-inflammatory effect, a mode of blending pyridoxine (vitamin B6) or a salt thereof into an oral composition has been known.

[0003] Specifically, for example, in Patent Document 1 below, an aspect of containing tocopherol nicotinate and / or tocopherol acetate together with pyridoxine or a salt thereof in an oral composition for the purpose of stably containing pyridoxine or a salt thereof is described.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] If pyridoxine or a salt thereof is blended as a component of a liquid oral composition, favorable properties such as astringency in the oral mucosa can be imparted. However, depending on the blending amount of pyridoxine or a salt thereof, the liquid oral composition may change color over time during storage or the like, or an unpleasant sour taste derived from pyridoxine or a salt thereof may occur during use of the liquid oral composition.

[0006] An object of the present invention is to provide a liquid oral composition that has astringency, can effectively suppress discoloration over time, and can improve sour taste during use.

Means for Solving the Problems

[0007] The present inventors diligently conducted research to suppress discoloration over time in liquid oral compositions containing pyridoxine or its salts, and found that the above problem can be solved by incorporating glycerin and at least one selected from the group consisting of sorbitol, propylene glycol, and polyethylene glycol in a specific ratio, thus completing the present invention. The present invention provides the following [1] to [5]. [1] A liquid oral composition comprising (A) component: pyridoxine or a salt thereof, (B) component: glycerin, and (C) component: at least one selected from the group consisting of sorbitol, propylene glycol, and polyethylene glycol, wherein the ratio of the content (mass%) of component (B) to the content (mass%) of component (C) is less than 1. [2] (D) Components: A liquid oral composition according to [1], comprising at least one sweetener selected from the group consisting of sodium saccharin, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol. [3] (E) component: A liquid oral composition according to [1] or [2], comprising at least one selected from the group consisting of tocopherol acetate and tocopherol nicotinate. [4] A liquid oral composition according to any one of items [1] to [3], wherein the ratio of the value obtained by multiplying the content (mass%) of component (A) by 100 to the sum of the content (mass%) of component (B) and component (C) is 0.03 to 34. [5] A liquid oral composition according to any one of items [1] to [4], wherein the water content is 50% by mass or more. [Effects of the Invention]

[0008] According to the present invention, in a liquid oral composition having an astringent sensation and containing pyridoxine or a salt thereof, it is possible to suppress discoloration over time caused by the inclusion of pyridoxine or a salt thereof, and to improve the sour taste during use. [Modes for carrying out the invention]

[0009] <Liquid oral composition> The liquid oral composition of the present invention contains components (A), (B), and (C) described below, wherein the ratio (B) / (C) described below satisfies a predetermined numerical range, preferably further containing component (D), and more preferably further containing component (E). In addition, other known additives may be optionally added in addition to the above components, as long as they do not interfere with the effects of the present invention.

[0010] [(A) component] (A) Component is pyridoxine or a salt thereof. By including component (A), the liquid oral composition can be given a periodontal disease prevention effect. According to the oral composition of this embodiment, pyridoxine or a salt thereof is a component that can also provide an astringent sensation, especially on the oral mucosa, when used.

[0011] In this embodiment, the pyridoxine salt is not particularly limited as long as it is a pharmaceutically acceptable salt that exhibits the effects described above. Examples of pyridoxine salts include pyridoxine hydrochloride, pyridoxine sulfate, pyridoxine nitrate, pyridoxine hydrobromide, and pyridoxine phosphate, among which pyridoxine hydrochloride is preferred.

[0012] Here, pyridoxine hydrochloride (pyridoxine hydrochloride) is the hydrochloride salt of pyridoxine and is a type of vitamin B6. (A) Component may be used individually or in combination of two or more of the above. In addition, commercially available products may be used for component (A).

[0013] [(B) Component] Component (B) is glycerin. By including component (B) in a predetermined ratio relative to component (C), the discoloration over time and sour taste of the liquid oral composition caused by component (A) can be suppressed and improved. (B) Commercially available products can be used as the component.

[0014] [(C) component] It is at least one selected from the group consisting of sorbitol, propylene glycol, and polyethylene glycol. By including component (C) in a predetermined ratio with component (B), the discoloration of the liquid oral composition over time caused by component (A) can be suppressed.

[0015] Examples of polyethylene glycol include polyethylene glycol with an average molecular weight of 150 to 6000, preferably polyethylene glycol with an average molecular weight of 190 to 4000. Specifically, examples include PEG200, PEG300, PEG400, PEG600, and PEG4000. More preferably, PEG400 polyethylene glycol is used. The average molecular weight is the average molecular weight described in the Japanese Standards for Ingredients of Quasi-Drugs 2021.

[0016] (C) The component is preferably sorbitol and propylene glycol, and more preferably propylene glycol.

[0017] (C) As for component (C), one of the above may be used alone, or two or more may be used in combination, and commercially available products may be used.

[0018] [(D) component] Component (D) is at least one sweetener selected from the group consisting of sodium saccharin, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol. By including component (D), it is possible to improve the unpleasant taste that may arise when components (A), (B), and (C) are combined.

[0019] (D) The components are preferably sodium saccharin, sucralose, and xylitol, and more preferably sodium saccharin and xylitol. Component (D) may be used individually, in combination of two or more, or a commercially available product may be used.

[0020] In addition, sodium saccharin, sucralose, and acesulfame potassium are high-sensitivity sweeteners. In this specification, a high-sensitivity sweetener refers to a sweetener having a sweetness degree 100 to 1000 times that of sucrose.

[0021] [Component (E)] (E) component: At least one selected from the group consisting of tocopherol acetate and tocopherol nicotinate. By containing the (E) component, the off-flavor that may occur with the blending of the (A) component, (B) component, and (C) component can be improved.

[0022] In the present embodiment, examples of the tocopherol acetate and tocopherol nicotinate as the (E) component include d-α-tocopherol acetate, dl-α-tocopherol acetate, d-α-tocopherol nicotinate, and dl-α-tocopherol nicotinate. Among these, as the (E) component, d-α-tocopherol acetate, dl-α-tocopherol acetate, and dl-α-tocopherol nicotinate are preferable, it is more preferable to use dl-α-tocopherol acetate and / or dl-α-tocopherol nicotinate, and it is even more preferable to use dl-α-tocopherol acetate. As the (E) component, one of the above may be used alone, two or more may be used in combination, and commercially available products can also be used.

[0023] The liquid oral composition of the present invention contains the (A) component, (B) component, and (C) component. Further, the liquid oral composition of the present invention preferably further contains any one or more components of (D) to (E) components, and more preferably contains a combination of the (D) component and the (E) component.

[0024] [Content of each component] -(Component (A))- The content of component (A) is not particularly limited, but is preferably 0.01% by mass or more, more preferably 0.015% by mass or more, or 0.02% by mass or more, relative to the total amount of the composition of the present invention. This provides a sufficient periodontal disease prevention effect along with an astringent sensation. The upper limit is preferably 0.5% by mass or less, 0.3% by mass or less, or 0.2% by mass or less, more preferably 0.12% by mass or less, or 0.1% by mass or less. It is preferable for the upper limit to satisfy the above numerical range in terms of suppressing discoloration and sourness during use caused by component (A). Therefore, the content of component (A) is preferably 0.01 to 0.5% by mass, 0.01 to 0.3% by mass or 0.01 to 0.2% by mass, more preferably 0.015 to 0.12% by mass or 0.02 to 0.1% by mass, relative to the total amount of the composition of the present invention.

[0025] -(B) Component- The content (pure amount) of component (B) is not particularly limited, but is preferably 0.4% by mass or more, or 0.5% by mass or more, and more preferably 2% by mass or more, relative to the total amount of the composition of the present invention. This makes it possible to further improve the discoloration of the liquid oral composition over time and the sourness during use caused by component (A). The upper limit is preferably 10% by mass or less, 9% by mass or less, or 8.5% by mass or less, and more preferably 8% by mass or less, or 7.5% by mass or less. This prevents adverse effects on the astringent feeling derived from component (A), and further makes it easier for component (D) or (E) to improve the unpleasant taste after use. Therefore, the content of component (B) is preferably 0.4 to 10% by mass, 0.4 to 9% by mass, 0.4 to 8.5% by mass, or 0.5 to 8.5% by mass, and more preferably 2 to 8% by mass, or 2 to 7.5% by mass, relative to the total amount of the composition of the present invention.

[0026] -(C) Component- The content (pure amount) of component (C) is not particularly limited, but is preferably 1% by mass or more, or 1.5% by mass or more, more preferably 2% by mass or more, or 2.5% by mass or more, relative to the total amount of the composition of the present invention. This further suppresses discoloration caused by component (A). The upper limit is preferably 20% by mass or less, or 12% by mass or less, more preferably 10% by mass or less, or 8% by mass or less. This prevents adverse effects on the astringent feeling caused by component (A), and further facilitates the improvement of unpleasant taste after use by component (D) or (E). Therefore, the content of component (C) is preferably 1 to 20% by mass or 1.5 to 12% by mass, more preferably 2 to 10% by mass or 2.5 to 8% by mass, relative to the total amount of the composition of the present invention.

[0027] -(B) component / (C) component- In the liquid oral composition of the present invention, the ratio of the content of component (B) (mass%) to the content of component (C) (mass%) (hereinafter referred to as "(B) / (C)") is less than 1, preferably 0.9 or less, and more preferably 0.8 or less. This suppresses the discoloration of the liquid oral composition over time caused by component (A). The lower limit is not particularly limited, but it should be greater than 0, preferably 0.01 or more. This allows the effects of the present invention to be more fully realized.

[0028] -(A)×100 / ((B)+(C))- The ratio of the value obtained by multiplying the content (mass%) of component (A) by 100 to the value obtained by adding the content (mass%) of component (B) to the content (mass%) of component (C) (hereinafter referred to as "(A) × 100 / ((B) + (C))") is not particularly limited, but is preferably 0.03 or more, or 0.05 or more, more preferably 0.08 or more, and even more preferably 0.13 or more. Its upper limit is preferably 34 or less, or 25 or less, more preferably 20 or less, and even more preferably 11 or less, 2.3 or less, or 1 or less. Therefore, the ratio (A) × 100 / ((B) + (C)) is preferably 0.03 to 34, or 0.05 to 25, more preferably 0.08 to 20, and even more preferably 0.13 to 11, 0.13 to 2.3, or 0.13 to 1. This allows the liquid oral composition to exhibit a more desirable astringent sensation while further suppressing discoloration caused by component (A).

[0029] -(D) Component- The content of component (D) is not particularly limited, but is preferably 0.00005% by mass or more, 0.00008% by mass or more, or 0.0001% by mass or more, and more preferably 0.0005% by mass or more, 0.0008% by mass or more, or 0.001% by mass or more. This can further improve the unpleasant aftertaste of the liquid oral composition that may result from the combined use of components (A), (B), and (C). The upper limit is preferably 15% by mass or less, 12% by mass or less, or 10% by mass or less, and more preferably 8% by mass or less, 6% by mass or less, or 5% by mass or less. This can prevent the unpleasant taste from being enhanced by the taste derived from component (D). Therefore, the content of component (D) is preferably 0.00005 to 15% by mass, 0.00008 to 12% by mass, or 0.0001 to 10% by mass, and more preferably 0.0005 to 8% by mass, 0.0008 to 6% by mass, or 0.001 to 5% by mass, based on the total amount of the composition of the present invention.

[0030] When the (D) component contains only a highly sensitive sweetener, its content is not particularly limited, but is preferably 0.00008% by mass, or 0.0001% by mass or more, more preferably 0.001% by mass or more, or 0.0015% by mass or more, relative to the total amount of the composition of the present invention. Its upper limit is preferably 12% by mass or less, 1% by mass or less, 0.1% by mass or less, or 0.05% by mass or less, more preferably 0.01% by mass or less, or 0.005% by mass or less. Therefore, when the (D) component contains only a highly sensitive sweetener, its content is preferably 0.00008 to 12% by mass, 0.0001 to 1% by mass, 0.0001 to 0.1% by mass, or 0.0001 to 0.05% by mass, more preferably 0.001 to 0.01% by mass, or 0.0015 to 0.005% by mass.

[0031] When component (D) contains only sweeteners other than highly sensitive sweeteners, or both highly sensitive sweeteners and sweeteners other than highly sensitive sweeteners, the content is not particularly limited, but is preferably 0.00005% by mass or more, or 0.00008% by mass or more, and more preferably 1% by mass or more, relative to the total amount of the composition of the present invention. The upper limit is preferably 15% by mass or less, or 12% by mass or less, and more preferably 10% by mass or less, or 5% by mass or less. Therefore, when component (D) contains only sweeteners other than highly sensitive sweeteners, or both highly sensitive sweeteners and sweeteners other than highly sensitive sweeteners, the content is preferably 0.00005 to 15% by mass, or 0.00008 to 12% by mass, and more preferably 1 to 10% by mass, or 1 to 5% by mass.

[0032] -((A)×100+(B)+(C)) / (D)- The ratio of the value obtained by multiplying the content of component (A) by 100, plus the content of component (B) and component (C) (mass%), to the content of component (D) (hereinafter referred to as "((A) × 100 + (B) + (C)) / (D)") is not particularly limited, but is preferably 0.01 or more, more preferably 0.05 or more, and even more preferably 0.1 or more. Its upper limit is preferably 300,000 or less, or 100,000 or less, more preferably 50,000 or less, or 45,000 or less, and even more preferably 35,000 or less. Therefore, the ratio ((A)×100+(B)+(C)) / (D) is preferably 0.01 to 300,000, or 0.01 to 100,000, more preferably 0.05 to 50,000, or 0.05 to 45,000, and even more preferably 0.1 to 35,000. This allows the effects of the present invention to be exhibited more favorably.

[0033] When the (D) component contains only a highly sensitive sweetener, the ratio ((A)×100+(B)+(C)) / (D) is not particularly limited, but is preferably 1 or more, more preferably 50 or more, or 80 or more, and even more preferably 100 or more. Its upper limit is preferably 300,000 or less, more preferably 100,000 or less, or 50,000 or less, and even more preferably 35,000 or less. Therefore, when the (D) component contains only a highly sensitive sweetener, the ratio ((A)×100+(B)+(C)) / (D) is preferably 1 to 300,000, more preferably 50 to 100,000, or 80 to 50,000, and even more preferably 100 to 35,000. By satisfying the above numerical range for the ratio ((A)×100+(B)+(C)) / (D), the effects of the present invention can be more favorably exhibited.

[0034] When component (D) contains only sweeteners other than highly sensitive sweeteners, or both highly sensitive sweeteners and sweeteners other than highly sensitive sweeteners, the ratio ((A) × 100 + (B) + (C)) / (D) is not particularly limited, but is preferably 0.01 or more, more preferably 0.05 or more, or 0.08 or more, and even more preferably 0.1 or more. Its upper limit is preferably 500 or less, more preferably 200 or less, or 100 or less, and even more preferably 50 or less. Therefore, when component (D) contains only sweeteners other than highly sensitive sweeteners, or both highly sensitive sweeteners and sweeteners other than highly sensitive sweeteners, the ratio ((A) × 100 + (B) + (C)) / (D) is preferably 0.01 to 500, more preferably 0.05 to 200, or 0.08 to 100, and even more preferably 0.1 to 50.

[0035] -(E) Component- The content of component (E) is not particularly limited, but is preferably 0.03% by mass or more, or 0.04% by mass or more, and more preferably 0.05% by mass or more, relative to the total amount of the composition of the present invention. This can further improve the unpleasant aftertaste of the liquid oral composition that may occur when components (A), (B), and (C) are used in combination. The upper limit is preferably 0.5% by mass or less, or 0.3% by mass or less, and more preferably 0.2% by mass or less. This can further prevent the unpleasant taste from being enhanced by the taste derived from component (E). Therefore, the content of component (E) is preferably 0.03 to 0.5% by mass or 0.04 to 0.3% by mass, and more preferably 0.05 to 0.2% by mass, relative to the total amount of the composition of the present invention.

[0036] -((A)×100+(B)+(C)) / (E)- The ratio of the value obtained by multiplying the content of component (A) by 100, plus the content of component (B) and component (C) (mass%), to the content of component (E) (hereinafter referred to as "((A)×100+(B)+(C)) / (E)") is not particularly limited, but is preferably 5 or more, or 10 or more, more preferably 30 or more, 60 or more, or 80 or more, and even more preferably 100 or more. Its upper limit is preferably 1500 or less, or 1200 or less, more preferably 1000 or less, 900 or less, and even more preferably 700 or less. Therefore, the ratio ((A)×100+(B)+(C)) / (E) is preferably 5 to 1500, or 10 to 1200, more preferably 30 to 1000, 60 to 900, or 80 to 700, and even more preferably 100 to 700. This allows the effects of the present invention to be exhibited more favorably.

[0037] [Optional ingredients] The liquid oral composition of this embodiment may contain optional components other than those already described, provided that the effects of the present invention are not impaired. These will be described in detail below.

[0038] Optional components include, for example, solvents, humectants, surfactants, medicinal ingredients, oily ingredients, sweeteners, preservatives, binders, pH adjusters, suspending agents, fragrances, and colorants (pigments). These can be formulated individually or in appropriate combinations of two or more. A detailed explanation follows below.

[0039] In this specification, the content of each component is based on the amount of each component added when manufacturing the liquid oral composition.

[0040] -solvent- The liquid oral composition of this embodiment may further contain a solvent. Preferably, water (purified water) or ethanol can be used as the solvent. The solvent may be one of the above solvents alone, or two or more solvents in combination, or a commercially available product may be used.

[0041] (moisture) The water content of the liquid oral composition of the present invention is preferably 50% by mass or more, more preferably 60% by mass or more, or 70% by mass or more, and even more preferably 75% by mass or more, or 80% by mass or more.

[0042] (ethanol) The amount of ethanol in the liquid oral composition of the present invention may be 20% by mass or less of the total composition, particularly 8% by mass or less, or it may be omitted and 0% by mass.

[0043] - Surfactants - Examples of surfactants include nonionic surfactants, amphoteric surfactants, anionic surfactants, or cationic surfactants.

[0044] Examples of nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers (e.g., polyoxyethylene cetyl ether), polyoxyethylene-polyoxypropylene alkyl ethers, polyoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene block copolymer, glycerin fatty acid esters, polyglycerin fatty acid esters, alkyl glycosides, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, polyoxyethylene sorbitan monooleate, sucrose fatty acid esters (e.g., sucrose stearate, sucrose palmitate), sugar alcohol fatty acid esters (e.g., maltitol fatty acid ester, lactitol fatty acid ester), fatty acid ethanolamides (e.g., lauric acid mono or diethanolamide), polyoxyethylene polyoxypropylene fatty acid esters, and polysorbates. The average number of moles of ethylene oxide added to polyoxyethylene hydrogenated castor oil is preferably 5 to 100 moles, more preferably 5 to 60 moles. The number of carbon atoms in the alkyl chain of polyoxyethylene alkyl ether is preferably 10 to 26, and the average number of moles of ethylene oxide added is preferably 2 to 50 moles. The number of carbon atoms in the fatty acid of polyglycerin fatty acid ester is preferably 10 to 20, and the average degree of polymerization of glycerin is 1 to 20. The average number of moles of ethylene oxide added to polyoxyethylene-polyoxypropylene alkyl ether is preferably 10 to 300 moles, the average number of moles of propylene oxide added is preferably 5 to 70 moles, and the number of carbon atoms in the alkyl group is preferably 10 to 20. The average number of moles of ethylene oxide added to polyoxyethylene polyoxypropylene glycol is preferably in the range of 1 to 300, more preferably in the range of 1 to 40, and the average number of moles of propylene oxide added is in the range of 1 to 70, more preferably in the range of 1 to 40. The average number of moles of ethylene oxide added to polyoxyethylene polyoxypropylene block copolymer is preferably in the range of 50 to 300, more preferably in the range of 50 to 150, and the average number of moles of propylene oxide added is in the range of 1 to 100, more preferably in the range of 20 to 70. The number of carbon atoms in the alkyl group of alkyl glycoside is preferably 8 to 20. The number of carbon atoms in the fatty acid of sucrose fatty acid ester is preferably 8 to 20. The number of carbon atoms in the fatty acid of sorbitan fatty acid ester is preferably 10 to 18. The number of carbon atoms in the fatty acid of polyoxyethylene sorbitan fatty acid ester is preferably 12 to 18, and the average number of moles of ethylene oxide added is preferably 20 to 80 moles. The number of carbon atoms in the alkyl chain of alkylolamide is usually 12 to 14.

[0045] Examples of amphoteric surfactants include betaine-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine (e.g., lauryldimethylaminoacetic acid betaine) and fatty acid amidopropyl betaine (e.g., coconut oil fatty acid amidopropyl betaine, cocamidopropyl betaine); and imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salts (e.g., N-coconut oil fatty acid acyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine), coconut oil fatty acid imidazolinium betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.

[0046] Examples of anionic surfactants include alkyl sulfates, acyl amino acid salts, acyl taurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, lauryl sulfoacetate, and polyoxyethylene alkyl sulfosuccinate. The alkyl and acyl groups may be linear or branched, saturated or unsaturated, and preferably have 10 to 20 carbon atoms, more preferably 12 to 18, and even more preferably 12 to 14. The salt can be selected from pharmacokinetically acceptable salts. Examples of pharmacokinetically acceptable salts include base addition salts and amino acid salts. Specific examples include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts. Among these, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0047] Examples of alkyl sulfates include lauryl sulfate (e.g., sodium lauryl sulfate) and myristoyl sulfate. Examples of acyl amino acid salts include acyl sarcosine salts such as lauroyl sarcosine salt (e.g., sodium lauroyl sarcosine) and myristoyl sarcosine salt; acyl glutamates such as lauroyl glutamate, myristoyl glutamate, and palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methylglycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt, and N-methyl-N-acyl alanine salt; and acyl aspartates such as lauroyl aspartate salt. Examples of acyl taurine salts include lauroyl methyl taurine salt (e.g., sodium lauroyl methyl taurine), N-methyl-N-acyl taurine salt, and N-cocoyl methyl taurine salt. Examples of α-olefin sulfonates include α-olefin sulfonates with 12 to 18 carbon atoms, such as tetradecene sulfonate. Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride monosulfate sodium and sodium lauryl sulfoacetate.

[0048] Examples of cationic surfactants include quaternary ammonium salt type cationic surfactants and amino acid-based cationic surfactants. Examples of quaternary ammonium salts include alkylpyridinium salts, benzethonium salts, benzalkonium salts, monoalkyltrimethylammonium salts, and dialkyldimethylammonium salts. Examples of salts include chloride salts and bromide salts. Examples of alkyl groups in alkylpyridinium salts, monoalkyltrimethylammonium salts, or dialkyldimethylammonium salts include alkyl groups with 8 to 22 carbon atoms. The upper or lower limit of the number of carbon atoms may be, for example, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 21. More specifically, it may be, for example, 9 to 21. Examples of quaternary ammonium salt type cationic surfactants include cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, behenyltrimethylammonium chloride, distearyldimethylammonium chloride, laurylbenzyldimethylammonium chloride, hexadecyltrimethylammonium bromide, and stearyltrimethylammonium bromide. Examples of amino acid-based cationic surfactants include mono-N-long-chain acyl basic amino acid lower alkyl ester salts. Examples of basic amino acids constituting amino acid-based cationic surfactants include natural amino acids such as ornithine, lysine, and arginine. Synthetic amino acids such as α,γ-diaminobutyric acid can also be used. These may be optically active or racemic. The acyl group of the mono-N-long-chain acyl basic amino acid lower alkyl ester salt is preferably a saturated or unsaturated higher fatty acid residue having 8 to 22 carbon atoms. The upper or lower limit of the carbon number may be, for example, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 21. More specifically, it may be 9 to 21. Examples include single higher fatty acid residues such as lauroyl group, myristoyl group, palmitoyl group, and stearoyl group; and natural mixed higher fatty acid residues such as coconut oil fatty acid residues and beef tallow higher fatty acid residues. Examples of lower alkyl esters include alkyl esters having 1 to 8 carbon atoms. Specifically, these include methyl esters, ethyl esters, propyl esters, butyl esters, pentyl esters, hexyl esters, heptyl esters, octyl esters, and the like. Lower alkyl esters are preferably in salt form, and examples include inorganic salts such as hydrochloride, bromate, sulfate, and phosphate; and organic salts such as glycolate, acetate, lactate, succinate, tartrate, citrate, acidic amino acid salts, higher fatty acid salts, L- or DL-pyrrolidone carboxylate salts, pyroglutamate, and p-toluenesulfonate. Examples of amino acid-based cationic surfactants include N-coconut oil fatty acid acyl-L-arginine ethyl DL-pyrrolidone carboxylate. The surfactant may be used individually from the above-mentioned types, or in combination of two or more types, and commercially available products may be used.

[0049] The surfactant content is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, and even more preferably 0.1% by mass or more, when the total amount of the liquid oral composition is taken as 100% by mass. The upper limit is preferably 10% by mass or less, and more preferably 5% by mass or less. Therefore, the surfactant content is preferably 0.001 to 10% by mass, more preferably 0.01 to 5% by mass, and even more preferably 0.1 to 5% by mass, when the total amount of the liquid oral composition is taken as 100% by mass.

[0050] -Sweetener- The liquid oral composition of this embodiment may contain, in any amount, any suitable conventionally known sweetener other than component (D). Including a sweetener in the liquid oral composition can further improve the user experience.

[0051] Any sweetener other than component (D) may be used as the sweetener, such as aspartame, stevioside, stevia extract, p-methoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartin, thaumatin, and aspartylphenylalanine methyl ester. The sweetener may be used individually, in combination of two or more of the above examples, or commercially available products may be used. When using a sweetener, the amount can be appropriately determined within a range that does not impair the effects of the present invention.

[0052] -Fragrance- The liquid oral composition of this embodiment may contain a conventionally known and suitable fragrance in an arbitrarily suitable amount. The inclusion of a fragrance in the liquid oral composition can further improve the user experience.

[0053] Fragrances include, for example, natural essential oils such as peppermint oil, spearmint oil, Japanese mint oil, anise oil, cassia oil, clove oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange blossom oil), lemongrass oil, jasmine oil, rose oil, iris oil, thyme oil, sage oil, cardamom oil, coriander oil, rosemary oil, laurel oil, chamomile oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, grapefruit oil, lime oil, mandarin oil, yuzu oil, nutmeg oil, lavender oil, paraclete oil, vanilla oil, cinnamon oil, pimento oil, cinnamon leaf oil, and perilla oil; menthol, menthofran, carvone, cinnamic aldehyde, anethole, 1,8-cineole, methyl salicylate Fragrance components contained in the above natural essential oils, such as phosphate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spiranthol, n-decyl alcohol, citronellol, α-terpineol, linalyl acetate, phenylethyl glycidate, phenylethyl alcohol, allyl hexanoate, octanol, octanal, octyl acetate, caryophyllene, germacrene, viridiflorol, methyl cinnamate, methylheptin carbonate, ionone, ethyl-β-methylthiopropionate, cis-6-nonenol, carone, methyl jasmonate, citronellyl acetate, ethyl linalool, etc.Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, ethylcyclopentenolone, 3-hydroxy-4,5-dimethylfuran-2-one, cyclotene, 2-methylbutyric acid, acetate acid, propionic acid, cis-3-hexenol, trans-2-hexenal, undecalact Fragrance components such as decalactone, hexyl acetate, ethyl-2-methyl butyrate, benzyl alcohol, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), menthyl lactate, ethylene glycol-l-menthyl carbonate, maltol, ethyl maltol; plant extracts such as vanilla extract, chili pepper extract, ginger extract, pepper extract, Japanese pepper extract, cardamom extract;This also includes various blended flavors such as mint, fruit, and herb, which are created by combining several fragrance components and natural essential oils. Furthermore, fragrances that can also function as cooling agents include, for example, N-ethyl-p-menthane-3-carboxamide (N-ethyl-2-isopropyl-5-methylcyclohexanecarboxamide), N-[(ethoxycarbonyl)methyl)-p-menthane-3-carboxamide, Np-benzeneacetonitrile menthanecarboxamide, N-(2-(pyridine-2-yl)ethyl)-3-p-menthanecarboxamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazole-3-yl)-N-(thiophen-2-ylmethyl)acetamide, menthyl lactate, menthyl monosuccinate, vanillyl butyl ether, isopuregol, menthol glycoside ketal, and N-(4-cyanomethylphenyl). Other examples include -p-menthanecarboxamide, 3-l-mentoxypropane-1,2-diol, menthyl glyceryl ether, menthyl succinate, linalool oxide, vanillyl butyl ether, 5-methyl-2-propane-2-yl-N-(2-pyridine-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3carboxamide)ethyl acetate, 2-isopropyl-N,2,3-trimethylbutylamide, N-ethyl-2,2-diisopropylbutanamide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutanamide, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutanamide, menthyl glutarate, and 2-(4-methylphenoxy)-N-(1H-pyrazole-yl)-N-(thiophen-2-ylmethyl)acetamide isopuregol. As for the fragrance, one of the fragrances exemplified above may be used alone, or two or more may be used in combination. Furthermore, solvents may be used when compounding these fragrances. Examples of solvents include ethanol, propylene glycol, glycerin fatty acid esters, and triacetin. If the liquid oral composition contains a fragrance, its content is preferably 0.0000001 to 2% by mass, more preferably 0.00001 to 1% by mass, and even more preferably 0.01 to 0.5% by mass, when the total amount of the liquid oral composition is 100% by mass.

[0054] -Medicinal ingredients- Medicinal ingredients include, for example, enzymes such as dextranase, amylase, protease, and mutanase; anti-inflammatory agents such as tranexamic acid, allantoin, allantoin chlorohydroxyaluminum, ε-aminocaproic acid, azulene, sodium azulene sulfonate, glycyrrhizic acid or its salts (e.g., dipotassium glycyrrhizate), glycyrrhetinic acid or its salts (e.g., stearyl glycyrrhetinate), Phellodendron amurense, and Phellodendron amurense extract; cell activators such as sodium chloride and vitamins; bactericidal or antibacterial agents such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, thymol, lysozyme chloride, chlorhexidine, triclosan, zinc gluconate, and zinc citrate; and copper chlorophyll and gluconate. Examples of medicinal ingredients include: water-soluble copper compounds such as copper oxide; tartar preventatives such as zeolites, ethane hydroxydiphosphonates, and polyphosphates (e.g., sodium polyphosphate); vitamins such as vitamin C (e.g., ascorbic acid) and vitamin E (e.g., vitamin E other than component (E), such as tocopherol); astringents such as sodium chloride, alum, and lysozyme chloride; hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; amino acids such as alanine, glycine, proline, arginine, lysine, glutamine, and cysteine; peptides such as caropeptides; fluoride compounds such as sodium fluoride, sodium monofluorophosphate, and stannous fluoride; calcium compounds such as calcium glycerophosphate; and plant extracts such as thyme, scutellaria baicalensis, clove, and witch hazel. When a liquid oral composition contains medicinal ingredients, the amount can be an effective amount within a range that does not hinder the effects of the present invention (a range that is pharmacologically acceptable). The medicinal ingredients may be used individually from the above list, in combination of two or more, or commercially available products may be used.

[0055] -Oily components- Examples of oily components include hydrocarbons such as squalane, (light) liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols with 8 to 22 carbon atoms such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids with 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid); vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate. The oily component may be one of the above-mentioned types used alone, or two or more types used in combination, or a commercially available product may be used.

[0056] - Preservatives - The liquid oral composition of this embodiment may contain a conventionally known and suitable preservative in a suitably suitable amount. By including a preservative in the liquid oral composition, the preservative effect of the liquid oral composition can be ensured.

[0057] Examples of preservatives that may be included in the liquid oral composition include parahydroxybenzoic acid esters (e.g., methyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate), sodium benzoate, etc. The preservative may be used alone, in combination of two or more, or a commercially available product may be used.

[0058] -Wetting agent- The liquid oral composition of this embodiment may contain a conventionally known and suitable wetting agent in an arbitrarily suitable amount. By including an arbitrary wetting agent in the liquid oral composition, the user experience can be further improved.

[0059] Any wetting agent other than components (B) and (C) may be used, and sugar alcohols and polyhydric alcohols other than sugar alcohols are preferred. Examples of sugar alcohols include lactitol and reduced starch saccharides; and polyhydric alcohols such as ethylene glycol, dipropylene glycol, and butylene glycol. One of the above-mentioned wetting agents may be used alone, or two or more may be used in combination, and commercially available products may also be used. If the liquid oral composition contains a wetting agent, the total amount of the wetting agent, including components (B) and (C), is preferably 1 to 70% by mass, more preferably 1 to 65% by mass, even more preferably 1 to 60% by mass, and most preferably 1 to 40% by mass, when the total amount of the liquid oral composition is 100% by mass.

[0060] - Binding agent - The liquid oral composition of this embodiment may contain a binder.

[0061] Examples of binders that can be included in liquid oral compositions include conventionally known and suitable organic binders, such as polysaccharides, cellulosic binders (e.g., carboxymethylcellulose (CMC) or its salts (e.g., sodium carboxymethylcellulose), hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationized cellulose, etc., and pharmaceutically acceptable salts thereof such as their sodium salts), other polysaccharide thickeners (e.g., xanthan gum, guar gum, gellan gum, tragacanth gum, karaya gum, arabic gum, locust bean gum, carrageenan, sodium alginate), and synthetic water-soluble polymers (e.g., sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol, propylene glycol alginate). Furthermore, inorganic binders such as aluminum silicate may also be included. One or more of the above-exemplary binders can be included as binders, and commercially available products can also be used.

[0062] The content of the organic binder is preferably greater than 0% by mass, more preferably 0.001% by mass or more, and even more preferably 0.01% by mass or more, when the total amount of the liquid oral composition is considered as 100% by mass. The upper limit is preferably 11% by mass or less, more preferably 10% by mass or less, and more preferably 8% by mass or less. Therefore, the content of the organic binder is preferably greater than 0% by mass and 11% by mass or less, and more preferably 0.001 to 10% by mass, or 0.01 to 8% by mass. Alternatively, it may be omitted and 0% by mass.

[0063] - pH adjuster - The liquid oral composition of this embodiment may contain a conventionally known and suitable pH adjusting agent in a suitably suitable amount. By including a pH adjusting agent in the liquid oral composition, the pH stability of the liquid oral composition can be ensured.

[0064] Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, tartaric acid, acetic acid, fumaric acid, malic acid, and lactic acid, or their salts (e.g., sodium citrate); inorganic acids such as phosphoric acid (e.g., orthophosphoric acid), or their salts (e.g., potassium salts, sodium salts, and ammonium salts); and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic salts include disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, sodium carbonate, and sodium bicarbonate. pH adjusters may be used individually, in combination of two or more types, or commercially available products may be used.

[0065] The amount of pH adjuster can preferably be such that the pH of the liquid oral composition after addition is 5 to 9, and more preferably 5.5 to 8.5.

[0066] In this specification, the pH value preferably refers to the value obtained 3 minutes after the start of measurement at 25°C. The pH value can be measured using, for example, a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

[0067] -Suspension- A premixed emulsion can be used as a suspending agent. The oily component contained in the emulsion particles consists of oils and fats that are liquid at 25°C. As this emulsion, an O / W type (oil-in-water) emulsion can be used, obtained by emulsifying the oily component with an emulsifier using a polyhydric alcohol, water, etc. as a dispersion medium. It is preferable to add and blend such an O / W type emulsion. In this case, the oil droplet particles of the O / W type emulsion are dispersed in the liquid oral composition, and the dispersion medium mixes with the aqueous phase of the liquid oral composition, resulting in the existence of an O / W type emulsion.

[0068] Examples of oily components that are liquid at 25°C include liquid oils such as olive oil, camellia oil, and castor oil, and triglycerides with a carbon chain length of 6 to 12. These may be used individually or in combination of two or more, or commercially available products may be used. Examples of triglycerides include glyceryl tricaprylate, glyceryl tricaprate, and tri(caprylic / capric acid)glyceride. The amount of these components added to the total emulsion is preferably 10 to 60% by mass, particularly 20 to 50% by mass.

[0069] As emulsifiers, one or more nonionic surfactants such as glycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, and polyoxyethylene alkyl ethers can be used, and commercially available products can also be used. Among these, emulsifiers with an HLB value of 10 to 16 are preferred. Examples of glycerin fatty acid esters include decaglyceryl monomyristate and decaglyceryl monolaurate, which are decaglycerin monofatty acid esters with 12 to 16 fatty acid carbon atoms. The average number of moles of ethylene oxide added from polyoxyethylene hydrogenated castor oil is 10 to 100 moles, particularly 20 to 60 moles, and especially 20 moles. The average number of moles of ethylene oxide added from polyoxyethylene alkyl ethers is 4 to 20 moles, particularly 6 to 15 moles. Among these, decaglyceryl monomyristate and polyoxyethylene hydrogenated castor oil are particularly preferred. The amount of emulsifier added is usually preferably 5 to 30% by mass of the total emulsion including the dispersion medium, and more preferably 5 to 20% by mass.

[0070] As a dispersion medium, in addition to water, one or more polyhydric alcohols such as dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol with an average molecular weight of 190 to 630 can be used, and commercially available products can be used.

[0071] The above emulsion preferably has an average particle size of 30 to 300 nm, particularly 40 to 150 nm, and especially 40 to 120 nm. The content of the suspension agent is preferably 0.001 to 20% by mass, and more preferably 0.01 to 10% by mass, when the total amount of the oral composition is considered to be 100% by mass. The suspension may be one of the above-mentioned types used alone, or two or more types used in combination, or a commercially available product may be used.

[0072] -Colorants- The liquid oral composition of this embodiment may contain a conventionally known and suitable coloring agent in a suitably suitable amount.

[0073] Examples of colorants that a liquid oral composition may contain include natural pigments such as safflower red pigment, gardenia yellow pigment, gardenia blue pigment, perilla pigment, red yeast rice pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cocoa pigment, spirulina blue pigment, and tamarind pigment, as well as legally approved pigments such as Red No. 2, Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 227, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1, and riboflavin, copper chlorophyll sodium, and titanium dioxide (titanium oxide). When a liquid oral composition contains a colorant, its content is preferably 0.00001 to 3% by mass when the total amount of the liquid oral composition is 100% by mass. The coloring agents may be one of the above-mentioned types used alone, or two or more types used in combination, or commercially available products may be used.

[0074] -Other optional components- The liquid oral composition of this embodiment may contain other optional components in an optionally suitable amount.

[0075] In this embodiment, examples of other optional components that the liquid oral composition may contain include inorganic compounds such as titanium mica, titanium dioxide, zinc oxide, magnesium oxide, zirconium oxide, and hydroxyapatite; natural polymer compounds such as agar, gelatin, starch, and glucomannan; synthetic polymer compounds or copolymers thereof such as polyvinyl acetate, acrylic resin, polyurethane, polyester, polyvinyl chloride, nylon powder, and polyethylene powder; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, and paraffin wax; higher alcohols such as cetanol and stearyl alcohol; polyisobutylene, polybutadiene, urethane, silicone, natural rubber, polysaccharides such as hyaluronic acid and pullulan, and cyclic sugars such as cyclodextrin. The content of these other optional components can be appropriately set within a range that does not hinder the effects of the present invention. Other optional components may be used individually, in combination of two or more, or commercially available products may be used.

[0076] [Dosage Forms and Uses of Liquid Oral Compositions] In this specification, "liquid oral composition" means an oral composition whose dosage form is liquid.

[0077] The liquid oral composition of this embodiment can be widely used in oral applications. Examples of applications include mouthwashes (mouthwash, liquid toothpaste) and oral fresheners (sprays, etc.). In this specification, "liquid toothpaste" refers to a product used in conjunction with brushing, while "mouthwash" refers to a product used to rinse the mouth without brushing. Furthermore, "mouthwash" is a general term that includes "liquid toothpaste" and "mouth rinse."

[0078] In this embodiment, the liquid oral composition preferably has a pH of 5 to 9 at 25°C. The pH can be adjusted by adding a pH adjusting agent, changing the component composition, etc.

[0079] The liquid oral composition of the present invention should have a viscosity of 1000 mPa·s or less at 25°C as measured by a BL-type viscometer, and is particularly preferably 0.7 to 1000 mPa·s.

[0080] [Method for producing liquid oral composition] The method for producing the liquid oral composition of the present invention is not particularly limited. For example, one method involves sequentially adding raw material components to a solvent such as purified water, stirring, and dissolving them uniformly. The shape and material of the container in which the liquid oral composition of the present invention can be contained are not particularly limited. It can be used by filling it into a container that is normally used for liquid oral compositions. Specifically, such containers can be laminated containers consisting of a polyethylene layer, an ethylene methacrylic acid copolymer layer, a polyethylene terephthalate layer, an aluminum layer, a glass vapor-deposited layer, a polyvinyl alcohol layer, an ethylene vinyl alcohol copolymer layer, an acrylonitrile copolymer layer, paper, a recycled plastic layer, etc., or polyethylene containers, polyethylene terephthalate containers, polypropylene containers, etc. Various containers that are normally used for liquid oral compositions can be used, such as tubular containers, mechanical or differential pressure dispenser containers, film packaging containers such as pillow packaging, or pouch containers made of polyethylene or polypropylene such as linear polyethylene, low-density polyethylene, high-density polyethylene, etc. When the container is a pouch container, a pouch container made of low-density polyethylene, which has excellent flexibility, heat sealability, mechanical strength, heat resistance, etc., can be preferably used. [Examples]

[0081] The present invention will be described below with reference to examples. The following examples are not intended to limit the present invention.

[0082] <Raw materials used> -(A) component- Pyridoxine hydrochloride: Manufactured by Kyowa Pharma Chemical Co., Ltd., "Pyridoxine hydrochloride" -(B) Component- Glycerin: Manufactured by Sakamoto Pharmaceutical Co., Ltd., "Cosmetic Glycerin (85% aqueous solution)" -(C) component- Propylene glycol: Manufactured by ADEKA Corporation, "Propylene Glycol for Cosmetic Use" 70% Sorbitol: Manufactured by Mitsubishi Corporation Life Sciences Co., Ltd., "Sorbit D-70" Polyethylene glycol 400 (PEG400): Manufactured by Sanyo Chemical Industries, Ltd., "PEG-400" -(D) Component- Sodium saccharin: Manufactured by Aisan Chemical Industry Co., Ltd., "Sodium saccharin" Sucralose: Manufactured by San-Ei Gen F.F.I. Co., Ltd., "Sucralose" Acesulfame potassium (Acesulfame K): Manufactured by Celanese Japan, "Sunnet Acesulfame K" "Amalti MR-100" manufactured by Maltitol Mitsubishi Corporation Life Sciences Co., Ltd. Erythritol: Manufactured by Mitsubishi Chemical Foods Corporation, "Erythritol" Xylitol: Manufactured by Mitsubishi Corporation Life Sciences Co., Ltd., "Xylitol" -(E) Component- Tocopherol acetate: Manufactured by DSM Nutrition Japan, "dl-α-tocopherol acetate" Tocopherol nicotinate: Manufactured by Eisai Food Chemical Co., Ltd., "Tocopherol Nicotinate" -others- Citric acid: Manufactured by Komatsuya Co., Ltd., "Citric Acid, Quasi-Drug Ingredient Standard" Sodium citrate: Manufactured by Komatsuya Co., Ltd., "Quasi-drug ingredient standard: Sodium citrate" Sodium benzoate: Manufactured by Fushimi Pharmaceutical Co., Ltd., "Sodium Benzoate" Fragrance compositions A to S: The composition of each fragrance composition is shown in Tables 14 and 15. Water (purified water)

[0083] <Evaluation of liquid oral compositions> Liquid oral compositions were obtained by blending the raw materials shown in Tables 1-7 using conventional methods. Note that the AI ​​equivalent values ​​in the tables are the values ​​converted to pure content. Also, the amount of water (balance) does not include the amount of water carried in by each component. Furthermore, in Tables 1-7, and Tables 14 and 15, the numerical values ​​representing the content of each raw material are the content (mass%) relative to 100% by mass of the total composition.

[0084] The obtained liquid oral compositions (Examples 1-42 and Comparative Examples 1-8) were evaluated using the following evaluation method. The evaluation results are shown in Tables 1-7 below.

[0085] -Evaluation of the astringent sensation of the oral mucosa after use of the liquid oral composition- Ten expert panelists conducted a sensory evaluation of the presence and degree of astringency in the oral mucosa while using the liquid oral composition. Each panelist took 20 mL of the liquid oral composition into their mouth, rinsed for 30 seconds, and evaluated the astringency felt in the oral mucosa after use according to the scoring criteria below. The average score from the ten expert panelists was calculated and judged as A, B, C, D, or E according to the evaluation criteria below.

[0086] Rating Criteria 5 points: I feel a very strong astringent sensation in my mouth. 4 points: I felt a strong astringent sensation in my mouth. 3 points: There is a constricting sensation in the mouth. 2 points: There is a slight astringent sensation in the mouth. 1 point: No astringent feeling in the mouth.

[0087] Evaluation criteria: A score of C or higher is considered a passing grade. A: Average score of 4.5 points or more B: Average score of 4.0 or higher but less than 4.5 C: Average score between 3.0 and 4.0 D: Average score between 2.0 and 3.0 E: Average score between 1.0 and 2.0 points

[0088] -Method for evaluating discoloration over time- Liquid oral compositions were filled into 50 mL vials and stored in constant temperature baths at 60°C and -5°C for one month. The appearance of the samples after storage was visually inspected, and the samples stored at 60°C were evaluated using the scoring criteria shown below, with the -5°C stored sample as the baseline. The average score was calculated after repeating the same test five times, and the scores were judged as A, B, C, D, or E according to the evaluation criteria below.

[0089] Rating Criteria 5 points: No discoloration whatsoever compared to the standard product. 4 points: There is a very slight discoloration to a light yellow compared to the standard product, but there is almost no difference. 3 points: There is a slight discoloration to a lighter yellow compared to the standard product, but it is not noticeable during use. 2 points: Compared to the standard product, there is discoloration ranging from dark yellow to brownish-red. 1 point: Compared to the standard product, there is discoloration to a dark brownish-red.

[0090] Evaluation criteria: A score of C or higher is considered a passing grade. A: Average score of 4.5 or higher B: Average score is between 4.0 and 4.5 points. C: Average score is between 3.0 and 4.0 D: Average score is between 2.0 and 3.0 E: Average score is less than 2.0 points

[0091] -Evaluation of the absence of acidity during use of liquid oral compositions- Ten expert panelists conducted a sensory evaluation of the presence and degree of acidity during use. Each panelist took 20 mL of the liquid oral composition into their mouth, rinsed for 30 seconds, and evaluated the perceived lack of acidity during use according to the scoring criteria below. The average score from the ten expert panelists was calculated and assigned a rating of A, B, C, or D according to the evaluation criteria below.

[0092] Judgment criteria 4 points: No sourness 3 points: Almost no sourness 2 points: Slightly sour. 1 point: It is sour.

[0093] Evaluation criteria: A grade of B or higher is considered a passing grade. A: Average score 3.5 points or more 4.0 points B: Average score between 3.0 and 3.5 points C: Average score between 2.0 and 3.0 D: Average score between 1.0 and 2.0 points

[0094] -Evaluation of the absence of unpleasant after-use odor in liquid oral compositions- Ten expert panelists conducted a sensory evaluation of the presence and degree of any unpleasant aftertaste. Each panelist took 20 mL of the liquid oral composition into their mouth, rinsed for 30 seconds, and evaluated the absence of any unpleasant aftertaste according to the scoring criteria below. The average score from the ten expert panelists was calculated and assigned a rating of A, B, C, D, or E according to the evaluation criteria below.

[0095] Judgment criteria 4 points: Not offensive 3 points: Almost no sarcasm. 2 points: Slightly sarcastic. 1 point: It's sarcastic.

[0096] Evaluation criteria: A score of C or higher is considered a passing grade. A: Average score 4.0 points B: Average score between 3.5 and 4.0 C: Average score between 3.0 and 3.5 points D: Average score between 2.0 and 3.0 E: Average score between 1.0 and 2.0 points

[0097] [Table 1]

[0098] [Table 2]

[0099] [Table 3]

[0100] [Table 4]

[0101] [Table 5]

[0102] [Table 6]

[0103] [Table 7]

[0104] While the liquid oral compositions of Comparative Examples 1 to 8 were inferior in either the astringent feeling of the oral mucosa after use, discoloration over time, or lack of acidity during use, the liquid oral compositions of the present invention of Examples 1 to 42, which contain predetermined amounts of component (A) and component (B), all exhibited good astringency of the oral mucosa after use, suppressed discoloration over time, and good lack of acidity during use. Of these, the liquid oral compositions of the present invention (Examples 26-42) further containing at least one of component (D) and component (E) also exhibited good lack of unpleasant after-use odor.

[0105] In the following prescription examples 1-34 (mouthwashes), the astringent sensation on the oral mucosa was good, discoloration over time was suppressed, and the absence of acidity during use was also good. Furthermore, the evaluation results did not change even when fragrance composition A used in the compositions of Examples 1-42, Comparative Examples 1-8, and Formulation Examples 1-34 was replaced with fragrance compositions B-S. Furthermore, it was confirmed that the same effects were obtained when the pH of formulations 1 to 34 was adjusted to 5, 6, 7, 8, and 9, respectively, by adjusting the total amount of pH adjusting agents (citric acid / sodium citrate, sodium dihydrogen phosphate / disodium hydrogen phosphate) within the range of 0.2 to 1% by mass.

[0106] (Example prescription) Examples of formulations of liquid oral compositions to which the present invention is applied are shown below.

[0107] [Table 8]

[0108] Table 9

[0109] Table 10

[0110] Table 11

[0111] Table 12

[0112] Table 13

[0113] Table 14

[0114] Table 15

[0115] Table 16

[0116] Table 17

[0117] Table 18

Claims

1. (A) Ingredients: Pyridoxine or its salt, (B) Component: Glycerin, (C) Component: Contains at least one selected from the group consisting of sorbitol, propylene glycol, and polyethylene glycol. The ratio of the content (mass%) of component (B) to the content (mass%) of component (C) is less than 1. Liquid oral composition.

2. (D) Components: A liquid oral composition according to claim 1, comprising at least one sweetener selected from the group consisting of sodium saccharin, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol.

3. (E) Component: A liquid oral composition according to claim 1 or 2, comprising at least one selected from the group consisting of tocopherol acetate and tocopherol nicotinate.

4. The liquid oral composition according to claim 1 or 2, wherein the ratio of the value obtained by multiplying the content (mass%) of component (A) by 100 to the sum of the content (mass%) of component (B) and component (C) is 0.03 to 34.

5. A liquid oral composition according to claim 1 or 2, wherein the water content is 50% by mass or more.

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