Insect repellent composition

Abstract

This invention relates to an insect repellent composition that, when applied to the skin, provides a long-lasting repellent effect while simultaneously offering a pleasant cooling sensation without causing unpleasant irritation or burning. [Solution] The following components (A) to (C): (A) One or more non-volatile liquid oils selected from silicone oils, ester oils, ether oils, hydrocarbon oils, aliphatic alcohols, and polyhydric alcohols, in an amount of 13% to 50% by mass. (B) Hydrophilic fine particles containing silica particles and / or silicate particles, with a median volume particle size of 1 μm or more and 40 μm or less. (C) Menthol An insect repellent composition containing the following, wherein the mass ratio ((C) / (A)) of the content of component (C) to the content of component (A) is 0.0008 or more and 0.45 or less.

Description

Technical Field

[0001] The present invention relates to a pest repellent composition.

Background Art

[0002] Flying pests such as mosquitoes, flies, and bees are generated and bred from polluted areas such as drainage and decaying food, and by flying, they approach animals such as humans and cause various harms to the animals. Among them, blood-sucking pests such as mosquitoes are attracted by carbon dioxide and body odor exhaled from animals while sensing the body temperature of the animals, reach the skin surface of the animals, and suck blood. When bitten by a mosquito, not only itching occurs, but it can also be a cause of rash and dermatitis at the blood-sucking site, and in some cases, it can transmit pathogens such as dengue fever, Zika fever, yellow fever, encephalitis, and malaria. Therefore, it is considered to be very harmful hygienically.

[0003] As countermeasures for repelling such pests, various compositions for application to the skin have been developed. Among them, as an active ingredient for repelling pests, a technique using a non-volatile liquid oily component having specific values of surface tension and viscosity has also been developed.

[0004] For example, Patent Document 1 discloses a pest repellent composition containing such a non-volatile liquid oily component and a film-forming polymer in specific amounts, aiming to improve the repellent persistence effect and its water resistance. Further, Patent Document 2 discloses a pest repellent composition containing such a non-volatile liquid oily component and a specific repellent component such as N,N-diethyltoluamide in specific amounts, and attempts have been made to enhance the persistence of the repellent effect while reducing the unpleasant odor derived from the repellent component.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Patent Document

Summary of the Invention

[0006] Incidentally, menthol, known for its pleasant aroma and refreshing coolness, is used in various compositions to exert its effects, but depending on the amount it contains, it may cause unpleasant irritation or burning sensations. Under these circumstances, the inventors of the present invention have newly noticed that using menthol in insect repellent compositions can unexpectedly effectively suppress the unpleasant irritation and burning sensations when applied to the skin, providing a pleasant cooling sensation while synergistically enhancing the repellent effect, leading to the present invention.

[0007] Therefore, the present invention relates to an insect repellent composition that, when applied to the skin, can fully exhibit a long-lasting repellent effect while providing a pleasant cooling sensation without causing unpleasant irritation or burning. [Means for solving the problem]

[0008] Therefore, after various studies, the inventors discovered that by containing a specific amount of a specific non-volatile liquid oil, specific hydrophilic fine particles, and menthol, and by controlling the mass ratio of the specific non-volatile liquid oil to the menthol within a specific range, it is possible to obtain an insect repellent composition that exhibits a long-lasting repellent effect while providing a comfortable cooling sensation.

[0009] In other words, the present invention comprises the following components (A) to (C): (A) One or more non-volatile liquid oils selected from silicone oils, ester oils, ether oils, hydrocarbon oils, aliphatic alcohols, and polyhydric alcohols, in an amount of 13% to 50% by mass. (B) Hydrophilic fine particles containing silica particles and / or silicate particles, with a median volume particle size of 1 μm or more and 40 μm or less. (C) Menthol The present invention provides an insect repellent composition containing the above, wherein the mass ratio ((C) / (A)) of the content of component (C) to the content of component (A) is 0.0008 or more and 0.45 or less. [Effects of the Invention]

[0010] With the insect repellent composition of the present invention, when applied to the skin, users can enjoy a sustained insect repellent effect while experiencing a pleasant cooling sensation derived from menthol, without any unpleasant irritation or burning sensation. [Modes for carrying out the invention]

[0011] The present invention will be described in detail below. In this invention, "pest" refers to so-called "flying pests," which include pests that approach humans or other animals while flying and suck blood from their skin, or pests that transmit pathogenic bacteria or the like while flying, even if they do not suck blood, or pests whose flight itself causes discomfort to humans. These pests specifically include house mosquitoes such as Culex pipiens, Culex tritaeniorhynchus, Culex pipiens, and Culex aegypti; mosquitoes such as Aedes aegypti, Aedes albopictus, Anopheles sinensis, Aedes togo, Anopheles gambia, and Anopheles stepens; midges such as Chironomus serrata and Chironomus rufipes; black flies such as Chironomus nigricans, Chironomus rufipes, and Chironomus rufipes; and houseflies. Examples include flies such as the large housefly, small housefly, black fly, flesh fly, seed fly, onion fly, fruit fly, Drosophila melanogaster, drain fly, Cheche fly, and stable fly; horseflies such as the black fly, cow fly, blind fly, and spotted fly; midges such as the Tokunaga black midge, Oshima midge, and chicken midge; and wasps such as the yellow hornet, black-legged paper wasp, and honeybee.

[0012] Furthermore, in this invention, the "repellent effect" against pests primarily refers to the effect of preventing pests from staying on or immediately leaving the skin of animals such as humans after contact (residency inhibition effect). While it may also include the effect of keeping pests away from animals such as humans, it is distinct from the effect of exhibiting insecticidal power or the effect of eliminating pests. The pest repellent composition of this invention exhibits a particularly excellent repellent effect against mosquitoes among pests. More specifically, the pest repellent composition of this invention exhibits an excellent repellent effect against mosquitoes such as Culex pipiens, Culex tritaeniorhynchus, Culex pipiens, Culex aegypti, Aedes aegypti, and Aedes albopictus. In this invention, "landing" of an insect means that the insect approaches a person or other animal and lands on their skin, but only remains in contact with the skin for less than one second. In this invention, "staying" of an insect means that the insect approaches a person or other animal, lands on their skin, and remains in contact with the skin for one second or more.

[0013] Furthermore, the "cooling sensation" when the insect repellent composition of the present invention is applied to the skin means that a pleasant and cool sensation is obtained, accompanied by a refreshing and invigorating feeling derived from menthol, also known as a cooling sensation. Furthermore, "unpleasant irritation" refers to the tingling, unbearable numbness or pain derived from menthol that may be felt on the skin when the insect repellent composition of the present invention is applied to the skin. "Unpleasant burning sensation" refers to the stinging, burning, unbearable pain derived from menthol that may be felt on the skin when the insect repellent composition of the present invention is applied to the skin.

[0014] The insect repellent composition of the present invention contains, as component (A), 13% by mass to 50% by mass of one or more non-volatile liquid oils selected from silicone oil (a1), ester oil (a2), ether oil (a3), hydrocarbon oil (a4), aliphatic alcohol (a5), and polyhydric alcohol (a6). Pests have the property of avoiding landing on the surface of the skin or the like where their legs get wet in order to avoid the gravitational force generated from the surface of the skin or the like where their legs get wet. On the other hand, the component (A) contained in the pest repellent composition of the present invention acts as a main component that can exhibit a repellent effect of causing wetness on the legs of pests landing on the surface of the skin or the like and inhibiting the landing of pests. When the component (C) described later coexists in the pest repellent composition of the present invention, such a repellent effect will be enhanced synergistically and continuously. The term "non-volatile liquid oil agent" means a non-volatile and liquid oily component.

[0015] Here, "non-volatile" in component (A) means that the evaporation rate after drying at 25°C for 60 minutes under 1 atmospheric pressure is 50% or less. From the viewpoint of enhancing the repellent effect by allowing the component (A) to stay on the skin for a long time, the lower the evaporation rate value of the component (A), the more preferable it is. Specifically, it is more preferable that the evaporation rate after drying at 25°C for 120 minutes under 1 atmospheric pressure is 50% or less. The evaporation rate is a value measured in accordance with the German test standard DIN53249. Specifically, it is measured by the following procedures 1 to 4. 1. Measure the weight (P (g)) of a round filter paper with a diameter of 15cm. 2. Using a pipette, drop 0.3 g of a sample of component (A) onto the round filter paper, and immediately measure the weight (W0 (g)) of the filter paper. 3. In a non-ventilated environment, measure the weight of the filter paper at 25°C at 5-minute intervals with a weight measurement accuracy of about 0.001 g. After measuring 2, let the weight of the filter paper measured after 60 minutes be W 60 (g). 4. The value calculated by the formula {((W0 - P) - (W 60 - P)) / (W0 - P)} × 100 is taken as the evaporation rate (%).

[0016] Here, the "liquid" state of component (A) means that the viscosity at 23°C measured by a B-type rotational viscometer is 120,000 mPa·s or less. Further, from the viewpoint of enhancing the persistence of the repellent effect and the viewpoint of exhibiting good extensibility when applied to the skin, component (A) is preferably liquid at 25°C, more preferably liquid at 20°C, still more preferably liquid at 15°C, even more preferably liquid at 10°C.

[0017] From the viewpoints of ensuring the exhibition of a highly persistent repellent effect and the ease of availability, the surface tension of component (A) at 25°C is preferably 15 mN / m or more, more preferably 17 mN / m or more, preferably 40 mN / m or less, more preferably 30 mN / m or less, still more preferably 28 mN / m or less, even more preferably 25 mN / m or less, even more preferably 23 mN / m or less, even more preferably 21 mN / m or less. The surface tension of component (A) means the value measured by the Wilhelmy method using a platinum plate in an environment of 25°C using an automatic surface tensiometer "Tensiometer K100" (manufactured by KRUSS).

[0018] From the viewpoints of suppressing the volatility of component (A), ensuring the exhibition of a highly persistent repellent effect, and maintaining the expression of a good cooling sensation, the viscosity of component (A) at 23°C measured by a B-type rotational viscometer is preferably 1 mPa·s or more, preferably 400 mPa·s or less, more preferably 300 mPa·s or less, still more preferably 210 mPa·s or less, even more preferably 100 mPa·s or less, even more preferably 60 mPa·s or less, even more preferably 40 mPa·s or less, even more preferably 30 mPa·s or less.

[0019] Component (A) is preferably a poorly water-soluble or water-insoluble component from the viewpoint of continuously enhancing the repellent effect. Specifically, its solubility in 100g of water at 20°C is preferably 1g or less, more preferably 0.5g or less, even more preferably 0.1g or less, and even more preferably substantially 0g.

[0020] The silicone oil (a1) of component (A) includes one or more organopolysiloxanes (a1-1) selected from dimethylpolysiloxanes (dimethicone), such as linear dimethylpolysiloxane and cyclic dimethylpolysiloxane; dimethiconol (dimethylpolysiloxane having a hydroxyl group at the end); and methylphenylpolysiloxane, as well as one or more modified silicones (a1-2).

[0021] Among the components (a1-1), from the viewpoint of continuously enhancing the repellent effect and providing a good cooling sensation when applied to the skin, one or more selected from dimethylpolysiloxane, dimethiconol, and methylphenylpolysiloxane are preferred, one or more selected from dimethylpolysiloxane and dimethiconol are more preferred, dimethylpolysiloxane is even more preferred, and linear dimethylpolysiloxane is even more preferred.

[0022] Specifically, the modified silicone of component (a1-2) is one or more modified silicones selected from amino-modified silicones (dimethylpolysiloxane having an amino group), amino derivative silicones, fatty acid-modified silicones, alcohol-modified silicones, aliphatic alcohol-modified silicones, epoxy-modified silicones, fluorine-modified silicones, and alkyl-modified silicones (a1-2-1); Examples of modified silicones other than modified silicone (a1-2-1) include one or more types selected from polyether-modified silicone, polyglycerin-modified silicone, branched polyglycerol-modified silicone, alkylglyceryl ether-modified silicone, and carboxy-modified silicone (a1-2-2).

[0023] Among the modified silicones (a1-2-2), polyether-modified silicone refers to a structure in which the hydrocarbon groups at the side chains and / or terminals of the silicone oil are substituted with polyether groups. Suitable polyether groups for polyether-modified silicone include polyethylene oxy groups, polypropylene oxy groups, ethylene oxy groups (EO), and polyalkylene oxy groups (trimethylene oxy groups or propane-1,2-diyl oxy groups; PO) which are added in a block-like or random manner, and more preferably polyethylene oxy groups. As the polyether-modified silicone of component (a1-2-2), compounds in which polyether groups are grafted onto the silicone main chain, compounds in which silicone and polyether groups are bonded in a block-like manner, and the like can be used. Examples of such polyether-modified silicones include, for example, PEG-3 dimethicone, PEG-9 dimethicone, PEG-9 methyl ether dimethicone, PEG-10 dimethicone, PEG-11 methyl ether dimethicone, PEG-12 dimethicone, PEG / PPG-20 / 22 butyl ether dimethicone, PEG-32 methyl ether dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, lauryl PEG-10 tris(trimethylsiloxy)silylethyl dimethicone, PEG / PPG-19 / 19 dimethicone, cetyl PEG / PPG-10 / 1 dimethicone, PEG / PPG-30 / 10 dimethicone, and linear polyether-modified silicones in which dimethyl silicone units and polyether units are alternately copolymerized.

[0024] Among modified silicones (a1-2-2), polyglycerin-modified silicone refers to polyglycerin-modified silicones other than branched polyglycerol-modified silicones described later, which have monovalent polyglyceryl groups in their structure. Examples of such polyglycerin-modified silicones include, for example, polyglyceryl-3 disiloxane dimethicone, polyglyceryl-3 polydimethylsiloxyethyl dimethicone, and lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone.

[0025] Among the modified silicones (a1-2-2), branched polyglycerol-modified silicone refers to a modified silicone having a structure in which branched polyglycerol chains are bonded to both ends of dimethylpolysiloxane via linking groups containing oxyphenylene groups. Such branched polyglycerol-modified silicone of component (a1-2-2) can be produced, for example, by graft polymerization of a modified silicone having phenyl groups substituted with hydroxyl groups at both ends by adding 2,3-epoxy-1-propanol in the presence of an acidic or basic catalyst. Examples of such branched polyglycerol-modified silicones include, for example, bis(polyglyceryl-3 oxyphenyl propyl)dimethicone.

[0026] Among the modified silicones (a1-2-2), alkylglyceryl ether modified silicones are modified silicones produced by methods such as reacting an organohydrogenpolysiloxane having at least one silicon-hydrogen bond with the corresponding alkenyl glyceryl ether. Examples of such alkylglyceryl ether-modified silicones include, for example, a copolymer of two-terminated alkyl(C16-18)-modified dimethylsiloxane and methyl(undecylglyceryl ether)siloxane.

[0027] Among modified silicones (a1-2-2), carboxy-modified silicone refers to a modified silicone having a structure in which carboxyl groups are bonded to the side chains and / or terminals of the silicone oil, and in which the carboxyl groups may be bonded to the main chain of the silicone oil via linking groups. Examples of such carboxy-modified silicones include carboxydecyldimethicone, carboxydecyltrisiloxane, and biscarboxydecyldimethicone.

[0028] Among the components (a1), it is preferable to use at least component (a1-2-2) in combination with the other components (a1), and more preferably component (a1-1) and component (a1-2-2), from the viewpoint of enhancing the highly sustained repellent effect and ensuring that a good cooling sensation is sufficiently distributed to every corner of the applied skin.

[0029] The ester oil (a2) of component (A) can be one or more selected from ester oils (a2-1) having a linear or branched alkyl or alkenyl group or an aromatic hydrocarbon group having 1 to 23 carbon atoms, dialkyl carbonate compounds (a2-2) having one or more alkyl or alkenyl groups having 6 to 22 carbon atoms and which may also have an ethyleneoxy group attached, and other ester oils (a2-3).

[0030] Specific examples of ester oils for component (a2-1) include the following ester oils (a2-1-1), ester oil (a2-1-2), and ester oil (a2-1-3).

[0031] Ester oil (a2-1-1) is an ester oil having a linear or branched alkyl group or aromatic hydrocarbon group having 7 to 23 carbon atoms, preferably 9 to 21 carbon atoms, more preferably 9 to 17 carbon atoms, which may be substituted with a hydroxyl group, and a linear or branched alkyl group or alkenyl group having 1 to 22 carbon atoms, preferably 8 to 22 carbon atoms, more preferably 10 to 20 carbon atoms. Examples of such components (a2-1-1) include, specifically, myristyl 2-ethylhexanoate, cetyl 2-ethylhexanoate, stearyl 2-ethylhexanoate, isodecyl octanoate, isocetyl octanoate, isononyl isononanoate, isotridecyl isononanoate, cetearyl isononanoate, octyl propylheptanoate, methyl laurate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, ethylhexyl 2-palmitate, and isocetyl palmitate. Examples include one or more selected from 2-ethylhexyl stearate, isocetyl stearate, isotridecyl stearate, isopropyl isostearate, octyl isostearate, isocetyl isostearate, isostearyl isostearate, 2-ethylhexyl hydroxystearate, methyl oleate, oleyl oleate, isobutyl oleate, oleyl erucate, alkyl benzoate (alkyl with 12-15 carbon atoms), diethylhexyl naphthalenedicarboxylate, etc.

[0032] Ester oil (a2-1-2) is an ester oil having at least a carbonyl group and an alkyl or alkenyl group having 7 to 23 carbon atoms, preferably 7 to 17 carbon atoms, which may be substituted with a hydroxyl group. Specifically, such components (a2-1-2) include, for example, one or more selected from glyceryl tri-2-ethylhexanoate and glyceryl tricaprylate. These include one or more selected from jojoba oil, olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, castor oil, wheat germ oil, grape seed oil, thistle oil, evening primrose oil, macadamia nut oil, corn germ oil, avocado oil, etc.

[0033] The ester oil (a2-1-3) is an ester oil having an aromatic hydrocarbon group having 6 to 20 carbon atoms, preferably 6 to 12 carbon atoms, more preferably 6 to 10 carbon atoms, and an alkyl or alkenyl group having 1 to 23 carbon atoms, preferably 11 to 21 carbon atoms, more preferably 11 to 15 carbon atoms, and an alkylene oxy group having 2 to 4 carbon atoms added, wherein the average number of added moles is 1 to 50, preferably 1 to 10, more preferably 1 to 5. Examples of such components (a2-1-3) include, for example, one or more selected from the following: an ester of a 3-mol propylene oxide adduct of benzyl alcohol and myristic acid, or an ester of a 3-mol propylene oxide adduct of benzyl alcohol and 2-ethylhexanoic acid.

[0034] The dialkyl carbonate compound of component (a2-2) preferably has an alkyl group with 8 to 18 carbon atoms, more preferably 12 carbon atoms, and the average number of added ethyleneoxy groups is preferably 0 to 5, more preferably 0. Specific examples of such component (a2-2) include dioctyl carbonate.

[0035] Other ester oils of component (a2-3) include one or more selected from esters of polycarboxylic acids and alcohols, esters of polycarboxylic alcohols (excluding glycerin) and fatty acids, and esters of cyclohexanecarboxylic acid and glycol. Specifically, examples include one or more selected from diisopropyl dimer acid, diisopropyl adipate, diethoxyethyl succinate, 2-ethylhexyl succinate, propanediol dicaprate, esters of neopentyl glycol such as neopentyl glycol dicaprate and neopentyl glycol di-2-ethylhexanoate and fatty acids, and ester oils of cyclohexane-1,4-dicarboxylic acid and ethoxydiglycol.

[0036] Among the components (a2), from the viewpoint of continuously enhancing the repellent effect and providing a good cooling sensation when applied to the skin, one or more selected from components (a2-1-1) and (a2-3) are preferred, and one or more selected from isononyl isononanoate, isotridecyl isononanoate, isopropyl myristate, isopropyl palmitate, dioctyl carbonate, bisethoxydiglycol cyclohexane-1,4-dicarboxylic acid, and esters of neopentyl glycol and fatty acids are more preferred.

[0037] The ether oil (a3) ​​of component (A) can be one or more selected from dialkyl ether compounds (a3-1) and polyoxyalkylene alkyl ether compounds (a3-2). Component (a3-1) is an ether oil having two substituents selected from linear or branched alkyl or alkenyl groups having 6 to 22 carbon atoms, preferably 8 to 18 carbon atoms, more preferably 8 to 16 carbon atoms, and even more preferably 8 to 12 carbon atoms, and aromatic hydrocarbon groups having 6 to 24 carbon atoms, more preferably 8 to 16 carbon atoms, and even more preferably 8 to 12 carbon atoms. Examples of such components (a3-1) include one or more selected from dihexyl ether, dioctyl ether, dicaprylyl ether, and cetyl-1,3-dimethylbutyl ether.

[0038] Component (a3-2) is a polyoxyalkylene alkyl ether compound having an alkyl or alkenyl group with 6 to 22 carbon atoms, preferably 8 to 20 carbon atoms, more preferably 8 to 18 carbon atoms, and even more preferably 8 to 12 carbon atoms, and having a propyleneoxy group and / or an ethyleneoxy group added. The average number of moles of propyleneoxy groups added is preferably 1 to 13, more preferably 2 to 10, and even more preferably 3 to 10. The average number of moles of ethyleneoxy groups added is preferably 5 or less, more preferably 1 or less, and even more preferably 0. Examples of such components (a3-2) include one or more selected from polypropylene glycol, polyoxypropylene octyl ether, polyoxypropylene decyl ether, and polyoxypropylene lauryl ether.

[0039] Among the components (a3), component (a3-1) is preferred from the viewpoint of continuously enhancing the repellent effect and providing a good cooling sensation when applied to the skin.

[0040] The hydrocarbon oil (a4) of component (A) can be one or more selected from liquid paraffin, liquid isoparaffin, squalane, isohexadecane, isoeicosane, hydrogenated polyisobutene, light liquid isoparaffin, heavy liquid isoparaffin, α-olefin oligomer, and cycloparaffin.

[0041] Among the components (a4), one or more selected from liquid paraffin, liquid isoparaffin, and squalane are preferred from the viewpoint of continuously enhancing the repellent effect and providing a good cooling sensation when applied to the skin.

[0042] The aliphatic alcohol (a5) of component (A) may be one or more selected from monovalent linear aliphatic alcohols having 3 or more carbon atoms, such as oleyl alcohol; or monovalent branched aliphatic alcohols, such as butyloctanol, butyldecanol, hexyldecanol, and octyldodecanol. Among the components (a5), one or two selected from hexyldecanol and octyldodecanol are preferred from the viewpoint of sustained repellent effect and providing a good cooling sensation when applied to the skin.

[0043] The polyhydric alcohol (a6) of component (A) may be one or more selected from the following: aliphatic alcohols having 2 or more carbon atoms, such as ethylene glycol, propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, diethylene glycol, dipropylene glycol, and hexylene glycol; sugar alcohols having 4 or more carbon atoms, such as sorbitol, erythritol, pentaerythritol, xylitol, and mannitol; and aromatic alcohols. Among the components (a6), one or more selected from ethylene glycol, propylene glycol, and dipropylene glycol are preferred from the viewpoint of continuously enhancing the repellent effect and providing a good cooling sensation when applied to the skin.

[0044] Among the components (A), from the viewpoint of enhancing the highly sustained repellent effect and ensuring that a good cooling sensation is sufficiently distributed to every corner of the applied skin, one or more selected from components (a1), components (a2), components (a3), and components (a4) are preferred, one or more selected from components (a1), components (a2), and components (a4) are more preferred, one or more selected from components (a1) and components (a2) are even more preferred, component (a1) is even more preferred, and as component (a1), it is even more preferred to use at least component (a1-2-2) and other components (a1) in combination, and it is even more preferred to use component (a1-1) and component (a1-2-2) in combination. Furthermore, if component (A) includes component (a6), it is preferable that it also includes one or more selected from components (a1), (a2), (a3), (a4), and (a5).

[0045] The content of component (A) in the insect repellent composition of the present invention is 13% by mass or more, preferably 18% by mass or more, more preferably 25% by mass or more, 50% by mass or less, preferably 40% by mass or less, and more preferably 35% by mass or less, from the viewpoint of enhancing the highly sustained repellent effect and effectively suppressing unpleasant irritation and burning sensations, and ensuring that a good cooling sensation is sufficiently distributed to every corner of the applied skin.

[0046] More specifically, if component (A) contains component (a1), the content of such component (a1) in the insect repellent composition of the present invention is preferably 13% by mass or more, more preferably 18% by mass or more, even more preferably 25% by mass or more, preferably 50% by mass or less, more preferably 40% by mass or less, and even more preferably 35% by mass or less, from the same viewpoint as above. The content of component (a1) in the insect repellent composition of the present invention is preferably 13 to 50% by mass, more preferably 18 to 40% by mass, and even more preferably 25 to 35% by mass. If component (A) contains component (a2), component (a3), component (a4), or component (a5), the content of these components (a2), component (a3), component (a4), and component (a5) are all the same as the content of component (a1) above. More specifically, if component (A) contains component (a6), the content of such component (a6) in the insect repellent composition of the present invention is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, even more preferably 1% by mass or more, even more preferably 2% by mass or more, preferably 20% by mass or less, more preferably 15% by mass or less, even more preferably 10% by mass or less, and even more preferably 7% by mass or less. The content of component (a6) in the insect repellent composition of the present invention is preferably 0.1 to 20% by mass, more preferably 0.5 to 15% by mass, even more preferably 1 to 10% by mass, and even more preferably 2 to 7% by mass.

[0047] In particular, when component (A) is used in combination with component (a1-1) and component (a1-2-2), the content of component (a1-2-2) in the insect repellent composition of the present invention is preferably 0.1% by mass or more, more preferably 0.15% by mass or more, even more preferably 0.2% by mass or more, preferably 3% by mass or less, more preferably 2.3% by mass or less, and even more preferably 1.6% by mass or less, from the viewpoint of enhancing the highly sustained repellent effect and ensuring that a good cooling sensation is sufficiently distributed to every corner of the applied skin. Furthermore, the content of component (a1-2-2) in the insect repellent composition of the present invention is preferably 0.1 to 3% by mass, more preferably 0.15 to 2.3% by mass, and even more preferably 0.2 to 1.6% by mass. Furthermore, the content of component (a1-2-2) in 100% by mass of component (A) is preferably 0.2% by mass or more, more preferably 0.5% by mass or more, even more preferably 0.8% by mass or more, preferably 18% by mass or less, more preferably 6% by mass or less, and even more preferably 3% by mass or less.

[0048] The insect repellent composition of the present invention contains hydrophilic fine particles as component (B), which include silica particles and / or silicate particles and have a median volume particle size of 1 μm or more and 40 μm or less. The hydrophilic fine particles of component (B) refer to fine particles whose surface wetting tension at 23°C is 70 mN / m or more, and which include silica particles or silicate particles, or particles containing both silica particles and silicate particles. The surface wetting tension of the particles of component (B) at 23°C is preferably 70 mN / m or more, more preferably 73 mN / m or more, and may be 100 mN / m or less, or 95 mN / m or less, from the viewpoint of improving the highly persistent repellent effect and further enhancing the good cooling sensation on the applied skin. The wetting tension of the particle surface at 23°C refers to the value measured by a test using a wetting tension test mixture (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.). Specifically, in a 23°C environment, 0.2 mL of wetting tension test mixture No. 70 (surface tension 70 mN / m) is first measured into a container, and then 0.01 g of the particle to be measured is gently placed into the mixture. After 30 seconds, the particle surface is visually checked to see if it has been wetted by the mixture. If it has been wetted by the No. 70 (surface tension 70 mN / m) mixture, the wetting tension of the particle surface is determined to be 70 mN / m or higher, and the particle is judged to be hydrophilic. Similarly, for example, if the particle surface does not wet when No. 25.4 (surface tension 25.4 mN / m) is used as the wetting tension test mixture, but does wet when No. 22.6 (surface tension 22.6 mN / m) is used as the wetting tension test mixture, then the wetting tension of the particle surface is determined to be 23 mN / m.

[0049] Furthermore, the shape of component (B) can be, for example, spherical, plate-like, flattened, flaky, or irregularly shaped. Among these, a spherical or flattened shape is preferred from the viewpoint of further enhancing the feel on the skin to which it is applied.

[0050] As silica particles that may be included in component (B), porous silica particles are preferred from the viewpoint of further enhancing the cooling sensation on the applied skin while effectively suppressing the occurrence of unpleasant irritation and burning sensations. More specifically, the silicate particles that may be included in component (B) include one or more selected from, for example, talc particles, mica particles, sericite particles, smectite particles, montmorillonite particles, bentonite particles, and kaolin particles. Among these silica particles, one or two selected from talc particles and mica particles are preferred from the viewpoint of further enhancing the cooling sensation on the applied skin.

[0051] The median volume particle size of component (B) is 1 μm or larger, preferably 2 μm or larger, more preferably 3 μm or larger, 40 μm or smaller, preferably 30 μm or smaller, more preferably 20 μm or smaller, even more preferably 15 μm or smaller, and even more preferably 12 μm or smaller, from the viewpoint of effectively improving the feel on the skin to which it is applied. Note that the median particle size by volume is the volume-based median diameter (D) determined by the particle size distribution. 50 This means that the particle size distribution is measured using a laser diffraction / scattering particle size distribution analyzer.

[0052] The total content of silica particles and silicate particles in component (B) is preferably 80% by mass or more, more preferably 85% by mass or more, even more preferably 95% by mass or more, and even more preferably 100% by mass, from the viewpoint of effectively improving the feel on the applied skin.

[0053] The content of component (B) in the insect repellent composition of the present invention is preferably 0.5% by mass or more, more preferably 2% by mass or more, even more preferably 4% by mass or more, preferably 35% by mass or less, more preferably 16% by mass or less, and even more preferably 8% by mass or less.

[0054] The mass ratio ((B) / (A)) of the content of component (B) to the content of component (A) is preferably 0.01 or more, more preferably 0.05 or more, even more preferably 0.1 or more, preferably 2 or less, more preferably 1 or less, and even more preferably 0.25 or less, from the viewpoint of promoting the exertion of a highly persistent repellent effect. Furthermore, the mass ratio ((B) / (A)) of the content of component (B) to the content of component (A) is preferably 0.01 to 2, more preferably 0.05 to 1, and even more preferably 0.1 to 0.25.

[0055] More specifically, when component (A) contains component (a1), the mass ratio of the content of component (B) to the content of component (a1) ((B) / (a1)) is preferably 0.01 or more, more preferably 0.05 or more, even more preferably 0.1 or more, preferably 2 or less, more preferably 1 or less, and even more preferably 0.25 or less, and the mass ratio of the content of component (B) to the content of component (a1) ((B) / (a1)) is preferably 0.01 to 2, more preferably 0.05 to 1, and even more preferably 0.1 to 0.25. Furthermore, if component (A) contains component (a2), component (a3), component (a4), or component (a5), the mass ratio of the content of component (B) to the content of component (a2) ((B) / (a2)), the mass ratio of the content of component (B) to the content of component (a3) ​​((B) / (a3)), the mass ratio of the content of component (B) to the content of component (a4) ((B) / (a4)), and the mass ratio of the content of component (B) to the content of component (a5) ((B) / (a5)) are all the same as the mass ratio of the content of component (B) to the content of component (a1) ((B) / (a1)). More specifically, when component (A) contains component (a6), the mass ratio of the content of component (B) to the content of component (a6) ((B) / (a6)) is preferably 0.025 or more, more preferably 0.1 or more, even more preferably 0.4 or more, even more preferably 0.5 or more, preferably 70 or less, more preferably 32 or less, even more preferably 8 or less, and even more preferably 4 or less. Furthermore, the mass ratio of the content of component (B) to the content of component (a6) ((B) / (a6)) is preferably 0.025 to 70, more preferably 0.1 to 32, even more preferably 0.4 to 8, and even more preferably 0.5 to 4.

[0056] In particular, the mass ratio ((B) / (a1-2-2)) of the content of component (B) to the content of component (a1-2-2) is preferably 0.2 or more, more preferably 3 or more, even more preferably 7 or more, preferably 350 or less, more preferably 200 or less, and even more preferably 40 or less, from the viewpoint of promoting the exertion of a highly persistent repellent effect. Furthermore, the mass ratio ((B) / (a1-2-2)) of the content of component (B) to the content of component (a1-2-2) is preferably 0.2 to 350, more preferably 3 to 200, and even more preferably 7 to 40.

[0057] The insect repellent composition of the present invention contains menthol as component (C). While component (C) inherently provides a pleasant cooling sensation along with a good aroma, depending on the amount contained, it can conversely cause an unpleasant irritation or burning sensation, potentially preventing the user from experiencing a good cooling sensation. However, the insect repellent composition of the present invention unexpectedly enhances the repellent effect synergistically and sustainably while effectively suppressing the unpleasant irritation and burning sensation derived from menthol, thereby producing an excellent cooling sensation.

[0058] The content of component (C) in the insect repellent composition of the present invention is preferably 0.01% by mass or more, preferably 0.08% by mass or more, more preferably 0.2% by mass or more, even more preferably 0.4% by mass or more, preferably 8% by mass or less, more preferably 5% by mass or less, even more preferably 3% by mass or less, and even more preferably 2% by mass or less, from the viewpoint of synergistically and sustainably enhancing the repellent effect while ensuring the expression of an excellent cooling sensation, and from the viewpoint of effectively suppressing unpleasant irritation and burning sensations.

[0059] The mass ratio ((C) / (A)) of the content of component (C) to the content of component (A) is 0.0008 or more, preferably 0.004 or more, more preferably 0.008 or more, even more preferably 0.02 or more, 0.45 or less, preferably 0.25 or less, more preferably 0.1 or less, and even more preferably 0.05 or less, from the viewpoint of exhibiting a highly persistent repellent effect while effectively suppressing unpleasant irritation and burning sensations and providing a good cooling sensation. Furthermore, the mass ratio ((C) / (A)) of the content of component (C) to the content of component (A) is 0.0008 or more and 0.45 or less, preferably 0.004 to 0.25, more preferably 0.008 to 0.1, and even more preferably 0.02 to 0.05. More specifically, when component (A) contains component (a1), the mass ratio of the content of component (C) to the content of component (a1) ((C) / (a1)) is, from the same viewpoint as above, 0.0008 or more, preferably 0.004 or more, more preferably 0.008 or more, even more preferably 0.02 or more, 0.45 or less, preferably 0.25 or less, more preferably 0.1 or less, and even more preferably 0.05 or less. Furthermore, the mass ratio of the content of component (C) to the content of component (a1) ((C) / (a1)) is 0.0008 to 0.45, preferably 0.004 to 0.25, more preferably 0.008 to 0.1, and even more preferably 0.02 to 0.05. Furthermore, if component (A) contains component (a2), component (a3), component (a4), or component (a5), the mass ratio of the content of component (C) to the content of component (a1) ((C) / (a2)), the mass ratio of the content of component (C) to the content of component (a3) ​​((C) / (a3)), the mass ratio of the content of component (C) to the content of component (a4) ((C) / (a4)), and the mass ratio of the content of component (C) to the content of component (a5) ((C) / (a5)) are all the same as the mass ratio of the content of component (C) to the content of component (a1) ((C) / (a1)). More specifically, when component (A) contains component (a6), the mass ratio of the content of component (C) to the content of component (a6) ((C) / (a6)) is, from the same viewpoint as above, 0.0005 or more, preferably 0.005 or more, more preferably 0.01 or more, even more preferably 0.02 or more, 16 or less, preferably 10 or less, even more preferably 3 or less, and even more preferably 2 or less. Furthermore, the mass ratio of the content of component (C) to the content of component (a6) ((C) / (a6)) is 0.0005 to 16, preferably 0.005 to 10, more preferably 0.01 to 3, and even more preferably 0.02 to 2.

[0060] The mass ratio ((C) / (B)) of the content of component (C) to the content of component (B) is preferably 0.0009 or more, more preferably 0.01 or more, even more preferably 0.1 or more, preferably 16 or less, more preferably 10 or less, and even more preferably 0.9 or less, from the viewpoint of promoting the exertion of a highly sustained repellent effect while effectively suppressing unpleasant irritation and burning sensations and contributing to the expression of a good cooling sensation. Furthermore, the mass ratio ((C) / (B)) of the content of component (C) to the content of component (B) is preferably 0.0009 to 16, more preferably 0.01 to 10, and even more preferably 0.1 to 0.9.

[0061] The insect repellent composition of the present invention preferably further contains ethanol (D) in order to effectively dissolve or disperse the above components and combine excellent repellent effect with a good cooling sensation.

[0062] The content of component (D) in the insect repellent composition of the present invention is preferably 4% by mass or more, more preferably 6% by mass or more, even more preferably 9% by mass or more, preferably 17% by mass or less, more preferably 15% by mass or less, and even more preferably 13% by mass or less. Furthermore, the content of component (D) in the insect repellent composition of the present invention is preferably 4 to 17% by mass, more preferably 6 to 15% by mass, and even more preferably 9 to 13% by mass.

[0063] The mass ratio ((D) / (B)) of the content of component (D) to the content of component (B) is preferably 0.2 or more, more preferably 0.6 or more, even more preferably 0.8 or more, preferably 34 or less, more preferably 19 or less, and even more preferably 3 or less, from the viewpoint of promoting the exertion of a highly sustained repellent effect while effectively suppressing unpleasant irritation and burning sensations and contributing to the expression of a good cooling sensation. Furthermore, the mass ratio ((D) / (B)) of the content of component (D) to the content of component (B) is preferably 0.2 to 34, more preferably 0.6 to 19, and even more preferably 0.8 to 3.

[0064] The insect repellent composition of the present invention preferably further contains water (E). Furthermore, the insect repellent composition of the present invention is preferably an oil-in-water composition rather than an oil-in-oil composition, from the viewpoint of maintaining good storage stability, exhibiting a highly persistent and excellent repellent effect, and sufficiently providing a good cooling sensation while suppressing unpleasant irritation and burning sensations when applied to the skin.

[0065] The content of component (E) in the insect repellent composition of the present invention is preferably 30% by mass or more, more preferably 35% by mass or more, even more preferably 40% by mass or more, preferably 86% by mass or less, more preferably 78% by mass or less, and even more preferably 70% by mass or less. Furthermore, the content of component (E) in the insect repellent composition of the present invention is preferably 30% by mass or more and 86% by mass or less, more preferably 35 to 78% by mass, and even more preferably 40 to 70% by mass.

[0066] The mass ratio ((E) / (B)) of the content of component (E) to the content of component (B) is preferably 1 or more, more preferably 4 or more, even more preferably 6 or more, preferably 150 or less, more preferably 90 or less, and even more preferably 20 or less, from the viewpoint of promoting the exertion of a highly sustained repellent effect while effectively suppressing unpleasant irritation and burning sensations and contributing to the expression of a good cooling sensation. Furthermore, the mass ratio ((E) / (B)) of the content of component (E) to the content of component (B) is preferably 1 to 150, more preferably 4 to 90, and even more preferably 6 to 20.

[0067] In order to provide a good cooling sensation by effectively suppressing unpleasant irritation and burning sensations while exhibiting a highly sustained repellent effect, it is preferable to limit the content of repellent active ingredients other than ingredient (A) in the insect repellent composition of the present invention. Other effective repellent ingredients besides component (A) include, specifically, one or more selected from DEET (N,N-diethyltoluamide), Icaridin (1-methylpropyl-2-(2-hydroxyethyl)-1-piperidine carboxylate), and IR3535 (3-(acetylbutyl)aminopropionate ethyl ester), etc. The content of repellent active ingredients other than component (A) in the insect repellent composition of the present invention is preferably 15% by mass or less, more preferably 10% by mass or less, even more preferably 5% by mass or less, even more preferably 4% by mass or less, even more preferably 3% by mass or less, even more preferably 1% by mass or less, and even more preferably 0.1% by mass or less, or it is preferable that the insect repellent composition of the present invention does not contain any repellent active ingredients other than component (A).

[0068] The insect repellent composition of the present invention may contain, to the extent that it does not inhibit the effects of the present invention, other components such as surfactants, humectants, pH adjusters, antioxidants, preservatives, ultraviolet absorbers, various other medicinal components, fragrances, colorants, etc.

[0069] The insect repellent composition of the present invention is suitable for use as a topical skin preparation for application to the skin of animals such as humans. Examples of such topical skin preparations include topical pharmaceuticals and quasi-drugs such as ointments and creams, and skin cosmetics such as lotions and emulsions. The form of the insect repellent composition of the present invention may be appropriately selected from liquids, creams, lotions, emulsions, gels, ointments, etc., depending on the intended use.

[0070] The insect repellent composition of the present invention can be manufactured by conventional methods. For example, the insect repellent composition of the present invention can be manufactured by adding component (C) to a mixture of component (A) and component (B) and mixing them, and specifically, it can be manufactured by the method described in the examples.

[0071] With regard to the embodiments described above, the present invention further discloses the following insect repellent compositions. [1] The following components (A) to (C): (A) One or more non-volatile liquid oils selected from silicone oil (a1), ester oil (a2), ether oil (a3), hydrocarbon oil (a4), aliphatic alcohol (a5), and polyhydric alcohol (a6) in an amount of 13% to 50% by mass. (B) Hydrophilic fine particles containing silica particles and / or silicate particles, with a median volume particle size of 1 μm or more and 40 μm or less. (C) Menthol An insect repellent composition containing the following, wherein the mass ratio ((C) / (A)) of the content of component (C) to the content of component (A) is 0.0008 or more and 0.45 or less. [2] The insect repellent composition according to [1] above, wherein the silicone oil (a1) of component (A) is preferably one or more selected from organopolysiloxane (a1-1) and modified silicone (a1-2). [3] The insect repellent composition according to [2] above, wherein component (a1-1) is preferably one or more selected from dimethylpolysiloxane, dimethiconol, and methylphenylpolysiloxane, and more preferably linear dimethylpolysiloxane. [4] The insect repellent composition according to [2] or [3] above, wherein component (a1-2) is preferably one or more modified silicones (a1-2-1) selected from amino-modified silicones (dimethylpolysiloxane having an amino group), amino derivative silicones, fatty acid-modified silicones, alcohol-modified silicones, aliphatic alcohol-modified silicones, epoxy-modified silicones, fluorine-modified silicones, and alkyl-modified silicones, and one or more modified silicones (a1-2-2) other than modified silicones (a1-2-1) selected from polyether-modified silicones, polyglycerin-modified silicones, branched polyglycerol-modified silicones, alkylglyceryl ether-modified silicones, and carboxy-modified silicones.

[0072] [5] The insect repellent composition according to any one of the above [1] to [4], wherein the ester oil (a2) of component (A) is preferably one or more selected from ester oils (a2-1) having a linear or branched alkyl or alkenyl group or an aromatic hydrocarbon group having 1 to 23 carbon atoms, dialkyl carbonate compounds (a2-2) having one or more alkyl or alkenyl groups having 6 to 22 carbon atoms and which may have an ethyleneoxy group added, and other ester oils (a2-3). [6] The insect repellent composition according to any one of [1] to [5] above, wherein the ether oil (a3) ​​of component (A) is one or more selected from dialkyl ether compounds (a3-1) and polyoxyalkylene alkyl ether compounds (a3-2). [7] Any one of the above [1] to [6], wherein the hydrocarbon oil (a4) of component (A) is one or more selected from liquid paraffin, liquid isoparaffin, squalane, isohexadecane, isoeicosane, hydrogenated polyisobutene, light liquid isoparaffin, heavy liquid isoparaffin, α-olefin oligomer, and cycloparaffin. [8] Any one of the above [1] to [7], wherein the aliphatic alcohol (a5) of component (A) is one or more selected from monovalent linear aliphatic alcohols having 3 or more carbon atoms and monovalent branched aliphatic alcohols. [9] The insect repellent composition according to any one of the above [1] to [8], wherein the polyhydric alcohol (a6) of component (A) is one or more selected from aliphatic alcohols having 2 or more carbon atoms, sugar alcohols having 4 or more carbon atoms, and aromatic alcohols.

[10] The insect repellent composition according to any one of the above [1] to [9], wherein component (A) is preferably one or more selected from component (a1), component (a2), component (a3), and component (a4), more preferably one or more selected from component (a1), component (a2), and component (a4), even more preferably one or more selected from component (a1) and component (a2), even more preferably component (a1), and even more preferably a combination of at least component (a1-2-2) and other components (a1), and even more preferably a combination of component (a1-1) and component (a1-2-2).

[0073]

[11] The insect repellent composition according to any one of [1] to

[10] above, wherein the content of component (A) is preferably 18% by mass or more, more preferably 25% by mass or more, preferably 40% by mass or less, and more preferably 35% by mass or less.

[12] The insect repellent composition according to any one of [1] to

[11] above, wherein when component (a1-1) and component (a1-2-2) are used in combination, the content of component (a1-2-2) is preferably 0.1% by mass or more, more preferably 0.15% by mass or more, even more preferably 0.2% by mass or more, preferably 3% by mass or less, more preferably 2.3% by mass or less, and even more preferably 1.6% by mass or less.

[0074]

[13] The insect repellent composition according to any one of [1] to

[12] above, wherein the volume median particle size of component (B) is preferably 2 μm or more, more preferably 3 μm or more, preferably 30 μm or less, more preferably 20 μm or less, even more preferably 15 μm or less, and even more preferably 12 μm or less.

[14] The insect repellent composition according to any one of [1] to

[13] above, wherein the total content of silica particles and silicate particles in component (B) is preferably 80% by mass or more, more preferably 85% by mass or more, even more preferably 95% by mass or more, and even more preferably 100% by mass.

[15] The insect repellent composition according to any one of [1] to

[14] above, wherein the content of component (B) is preferably 0.5% by mass or more, more preferably 2% by mass or more, even more preferably 4% by mass or more, preferably 35% by mass or less, more preferably 16% by mass or less, and even more preferably 8% by mass or less.

[16] The insect repellent composition according to any one of [1] to

[15] above, wherein the mass ratio ((B) / (A)) of the content of component (B) to the content of component (A) is preferably 0.01 or more, more preferably 0.05 or more, even more preferably 0.1 or more, preferably 2 or less, more preferably 1 or less, and even more preferably 0.25 or less.

[17] The insect repellent composition according to any one of the above [4] to

[16] , wherein the mass ratio ((B) / (a1-2-2)) of the content of component (B) to the content of component (a1-2-2) is preferably 0.2 or more, more preferably 3 or more, even more preferably 7 or more, preferably 350 or less, more preferably 200 or less, and even more preferably 40 or less.

[0075]

[18] The insect repellent composition according to any one of the above [1] to

[17] , wherein the content of component (C) is preferably 0.01% by mass or more, preferably 0.08% by mass or more, more preferably 0.2% by mass or more, even more preferably 0.4% by mass or more, preferably 8% by mass or less, more preferably 5% by mass or less, even more preferably 3% by mass or less, and even more preferably 2% by mass or less.

[19] The insect repellent composition according to any one of the above [1] to

[18] , wherein the mass ratio ((C) / (A)) of the content of component (C) to the content of component (A) is preferably 0.004 or more, more preferably 0.008 or more, even more preferably 0.02 or more, preferably 0.25 or less, more preferably 0.1 or less, and even more preferably 0.05 or less.

[20] The insect repellent composition according to any one of the above [1] to

[19] , wherein the mass ratio ((C) / (B)) of the content of component (C) to the content of component (B) is preferably 0.0009 or more, more preferably 0.01 or more, even more preferably 0.1 or more, preferably 16 or less, more preferably 10 or less, and even more preferably 0.9 or less.

[0076]

[21] Preferably further containing ethanol (D), wherein the content of component (D) is preferably 4% by mass or more, more preferably 6% by mass or more, even more preferably 9% by mass or more, preferably 17% by mass or less, more preferably 15% by mass or less, and even more preferably 13% by mass or less, any one of the above [1] to

[20] insect repellent compositions.

[22] The insect repellent composition according to

[21] above, wherein the mass ratio ((D) / (B)) of the content of component (D) to the content of component (B) is preferably 0.2 or more, more preferably 0.6 or more, even more preferably 0.8 or more, preferably 34 or less, more preferably 19 or less, and even more preferably 3 or less.

[23] Preferably further containing water (E), the insect repellent composition according to any one of [1] to

[21] above, wherein the content of component (E) is preferably 30% by mass or more, more preferably 35% by mass or more, even more preferably 40% by mass or more, preferably 86% by mass or less, more preferably 78% by mass or less, and even more preferably 70% by mass or less.

[24] The insect repellent composition according to

[23] above, wherein the mass ratio ((E) / (B)) of the content of component (E) to the content of component (B) is preferably 1 or more, more preferably 4 or more, even more preferably 6 or more, preferably 150 or less, more preferably 90 or less, and even more preferably 20 or less.

[25] The insect repellent composition of the present invention preferably contains no insect repellent active ingredients other than component (A), which is preferable to any one of the above [1] to

[24] . [Examples]

[0077] The present invention will be described in detail below based on examples. Unless otherwise specified in the table, the content of each component is expressed in mass percent.

[0078] [Examples 1-6, Comparative Examples 1-3] Preparation of the composition Each composition was prepared according to the formulations shown in Tables 1 and 2. Specifically, components (B) and (E) were placed in a beaker, and while stirring with a stirrer, component (a1-2-2), which was dissolved in a portion of component (D), was added as needed, and the mixture was stirred for 1 hour to prepare the aqueous phase. Next, component (a1-1) was gradually added to the obtained aqueous phase while stirring with a propeller, and then component (C) and the remainder of component D) dissolved in another beaker were added and stirred. Using a TK Homomix MARKII 2.5 model from TK Robomix (Tokushu Kika Kogyo Co., Ltd.), the mixture was stirred at 8,000 rpm for 1 minute to obtain each oil-in-water type composition. Each of the obtained compositions was used for the following measurements and evaluations. The results are shown in Tables 1 and 2.

[0079] Measurement of the viscosity of component (A) The viscosity was measured using a Type B rotational viscometer (Viscometer TVB-10, manufactured by Toki Sangyo Co., Ltd.) according to JIS K7117-1:1999, with rotor M2, at a rotational speed of 12 rpm in a 23°C environment.

[0080] 《Evaluation test of repellent effect》 The evaluation tests were conducted according to the following procedures (I) to (III), and the repellency rate (%) was calculated and used as an indicator for evaluating the repellent effect. (I) Preparation for pest control (Aedes albopictus) Aedes albopictus eggs (manufactured by Sumitomo Techno Service) were reared in cages under conditions of 27°C and 60% relative humidity (RH), and adult Aedes albopictus (females) were collected. Specifically, after filling a transparent plastic pan with about 1 cm of water, filter paper on which the eggs were laid was placed to induce pupation. The pupae were then fed tropical fish food (TetraMin) as larval food. After one week, the pupae were collected with a dropper, transferred to 20 mL plastic cups, and placed in a cage with a mesh net. The pupae were then fed 10% sucrose in a 25 mL plastic tube as adult food, and pupation was induced. The emerged males and females were reared in the same cage for 5 days to allow mating. Afterward, the adults were collected using an aspirator, anesthetized by exposing them to ice for 5 minutes, and then only female mosquitoes were collected visually for the evaluation described below.

[0081] (II) Preparation for the start of the exam Fifty mated female mosquitoes collected in (I) were placed in a mesh-enclosed plastic cage (BugDorm-1 cage, size: 30cm x 30cm x 30cm), and the test was conducted under conditions of 30°C and 60% relative humidity (RH). Specifically, a 10cm x 3cm slit was first made in a silicone sleeve, into which the subject's arm was inserted. To activate the mosquitoes, air was blown into the plastic cage for 5 seconds. Next, the arm was inserted into the plastic cage without applying anything to the exposed skin through the slit in the silicone sleeve. Within 3 minutes of inserting the arm, it was confirmed that mosquitoes landed in two places on the exposed skin and remained there for more than 1 second. If a landed mosquito did not remain for more than 1 second, another mosquito was reintroduced into the plastic cage, and preparations for the start of the test were made.

[0082] (III) Calculation of the repellency rate In conducting the test, if a mosquito landed on an exposed area of ​​skin and remained there for more than one second, it was determined that the mosquito had not been repelled and that "a mosquito had landed." First, a 10cm x 3cm slit was made in the silicone sleeve, and the subject's arm was inserted. 3.3 mg / cm³ was then administered to the exposed skin area (10cm x 3cm) through the slit. 2 Each composition was applied evenly. Additionally, breath was blown into the plastic cage for 5 seconds to activate the mosquitoes. After applying the composition, the forearm was inserted into a plastic cage two hours later, and the number of mosquitoes that landed on it was counted from the time of insertion until three minutes later. Separately, a forearm without the composition applied (uncoated forearm) was also inserted into the plastic cage, and the number of mosquitoes that landed on it was counted from the time of insertion until three minutes later, in the same manner as with the coated forearm. Next, the number of mosquitoes that landed on the forearm coated with the obtained composition, and the number of mosquitoes that landed on the forearm not coated with the composition, were introduced into the following formula (x) to calculate the repellency rate (%). Evasion rate (%) ={1-(number of mosquitoes on the forearm treated with the composition) / (number of mosquitoes on the forearm not treated with the composition)} ×100···(x)

[0083] Evaluation of cooling sensation, and evaluation of pain / burning sensation. The composition obtained was applied to the skin of the forearm at a concentration of 3.3 mg / cm³. 2 The mixture was applied evenly and then spread evenly over 1 minute under conditions of 25°C and 57% relative humidity (RH). Next, 7 minutes after the composition was spread, the cooling sensation and pain / burning sensation were evaluated according to the following criteria.

[0084] • Evaluation of cooling sensation 5: I feel a very strong sense of coolness. 4: I feel a slightly stronger sense of coolness. 3: Neither 2: The cooling sensation feels slightly weaker. 1: Feeling less of a cooling sensation 0: No feeling of coolness at all

[0085] • Evaluation of pain and burning sensation 5: No pain or burning sensation at all. 4: Pain and burning sensation are slightly lessened. 3: Reduced pain and burning sensation 2: Neither 1: The pain and burning sensation are somewhat strong, but tolerable. 0: You feel intense pain or burning sensation.

[0086] [Table 1]

[0087] [Table 2]

[0088] *1: KF-96A-10cs, viscosity: 5 mPa·s, surface tension: 19 mN / m, manufactured by Shin-Etsu Chemical Co., Ltd. *2: SILICONE KF-6017, viscosity: 600mm 2 / s, manufactured by Shin-Etsu Chemical Co., Ltd. *3: HCS 160M5, mid-volume particle size: 5μm, manufactured by JGC Catalysts & Chemicals Co., Ltd.

[0089] Table 3 shows examples of formulations for the insect repellent composition of the present invention.

[0090] [Table 3]

Claims

1. The following components (A) to (C): (A) One or more non-volatile liquid oils selected from silicone oils, ester oils, ether oils, hydrocarbon oils, aliphatic alcohols, and polyhydric alcohols: 13% to 50% by mass (B) Hydrophilic fine particles containing silica particles and / or silicate particles, with a median volume particle size of 1 μm or more and 40 μm or less. (C) Menthol An insect repellent composition containing the following, wherein the mass ratio of the content of component (C) to the content of component (A) ((C) / (A)) is 0.0008 or more and 0.45 or less.

2. Furthermore, the insect repellent composition according to claim 1, further containing ethanol (D).

3. The insect repellent composition according to claim 2, wherein the content of component (D) is 4% by mass or more and 17% by mass or less.

4. The insect repellent composition according to claim 1 or 2, wherein the content of component (B) is 0.5% by mass or more and 35% by mass or less.

5. The insect repellent composition according to claim 1 or 2, wherein the mass ratio ((C) / (B)) of the content of component (C) to the content of component (B) is 0.0009 or more and 16 or less.

6. Furthermore, the insect repellent composition according to claim 1 or 2, further containing water (E).

7. The insect repellent composition according to claim 6, wherein the content of component (E) is 30% by mass or more and 86% by mass or less.

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